Analysis of sites of newly integrated DNA in cellular genomes is important to several fields, but methods for analyzing and visualizing these datasets are still under development. Here, we describe tools for data analysis and visualization that take as input integration site data from our INSPIIRED pipeline. Paired-end sequencing allows inference of the numbers of transduced cells as well as the distributions of integration sites in target genomes. We present interactive heatmaps that allow comparison of distributions of integration sites to (...) genomic features and that support numerous user-defined statistical tests. To summarize integration site data from human gene therapy samples, we developed a reproducible report format that catalogs sample population structure, longitudinal dynamics, and integration frequency near cancer-associated genes. We also introduce a novel summary statistic, the UC50, which provides a single number summarizing possible clonal expansion. Using these tools, we characterize ongoing longitudinal characterization of a patient from the first trial to treat severe combined immunodeficiency-X1, showing successful reconstitution for 15 years accompanied by persistence of a cell clone with an integration site near the cancer-associated gene CCND2. Software is available at https://github.com/BushmanLab/INSPIIRED. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Ideas 61.4 (2000) 635-655 [Access article in PDF] The Mystery of Truth: Louis-Claude de Saint-Martin's Enlightened Mysticism David Bates "... what truth! and what error!" --Goethe on Saint-Martin 1It is hardly surprising that Louis-Claude de Saint-Martin (1743-1803), the philosophe inconnu of late Enlightenment Europe, remains almost completely unknown outside of the marginalized and exotic disciplines of esoterism, theosophy, and mysticism. Although influential in (...) certain circles, Saint-Martin failed to penetrate the mainstream of Enlightenment thought, and what influence he did have in philosophy was largely felt outside of this period altogether, revealing itself in figures such as Maistre, 2 Lamartine, 3 and German Romantics like Franz von Baader. 4 In his own lifetime Saint-Martin was met with incredulity by the forces of rationalism. Voltaire was given a copy of Saint-Martin's 1775 text Des erreurs et de la vérité by a friend of d'Alembert. Voltaire later commented to the mathematician, "I don't believe anyone has ever printed anything more absurd, [End Page 635] more obscure, more crazy, and more stupid." 5 In the Tableau de Paris, Mercier described Saint-Martin and his martinist followers as a sect which turned its back on the paths opened up by sound physics, chemistry, and all natural history in order "to run headlong into an invisible world only they perceived." Saint-Martin taught that the objects we see around us are only "fantastic and deceptive images" and that the truth lies precisely where we cannot see it, Mercier explained. "Physical experiences," the cornerstone of the dominant sensationalist doctrine, were for the martinists only "errors," an "eternal source of folly and deception," wrote Mercier. 6 One review of Saint-Martin's works described their effect as analogous to that of a "pyramid covered in hieroglyphs, erected by an unknown man in a public square," in other words, completely mystifying. 7 The revolutionary Barnave would link martinism with all the other "metaphysical follies," which were, he believed, the result of an overly speculative tendency in eighteenth-century thought. 8For his part Saint-Martin rejected what he considered to be the anti-spiritual tendency of Enlightenment thought. Responding (as a mature student) to the professor Garat, one of the idéologue followers of Condillac, at the École normale in 1795, Saint-Martin wrote: I always admire how you protect youself from materialism by endorsing... the teachings of Condillac. Although I read little, I have just gone through (very quickly, it is true) his Essai sur les origines des connaissances humaines and his Traité des sensations. Whether I have poorly grasped it, or I haven't your secret, I have come across almost no passages which do not repel me; and, I can say, have not encountered one which attracts me. His statue, for example... seems to be a mockery of nature... For me, each of the author's ideas appears to be an attack against man, a veritable homicide. 9Mystic thought, it seems, must oppose Enlightenment. At best, mysticism during the period of Enlightenment will be seen as its "underside" 10 or as the [End Page 636] preparation for coming anti-Enlightenment Romantic doctrines. 11 Indeed, the end of the Enlightenment in France saw a marked interest in esoteric thought and a mystic sensibility. 12 However, the attempt to link mysticism and Enlightenment has almost always been a critical attempt to discover the "superstitious" core of eighteenth-century rationalist thought. In this perspective the study of mystic thought in its own terms can only have antiquarian value, for the mystic approach to truth is, it is claimed, always in the form of a secret, revealed knowledge that can never withstand disciplined analysis. Saint-Martin finds his way into history as either a footnote in large books on Romantic thinking, or as the protaganist in largely incomprehensible ones examining esoteric thought. 13Here, I do not want to claim that Saint-Martin should be "included" in the Enlightenment, but a sympathetic reading of this complex... (shrink)

Resumen En el presente estudio se aborda la descripción de la semántica de los marcadores evidenciales por lo visto y se ve que en el marco de la teoría de la relevancia (TR). Tomando como punto de partida el análisis que Albelda, M. (2018). ¿Atenuación del compromiso del hablante?: El caso de los evidenciales por lo visto y se ve que. Rilce, 34.3, 1179–1214. traza de ambos evidenciales en un corpus oral, se realizó un estudio tanto cuantitativo como cualitativo de (...) los patrones y el rango de interpretaciones de cada expresión en una muestra de géneros escritos formales procedentes del Corpus de Referencia del Español Actual (CREA). Los resultados cuantitativos mostraron algunas diferencias con respecto a los obtenidos por Albelda, M. (2018). ¿Atenuación del compromiso del hablante?: El caso de los evidenciales por lo visto y se ve que. Rilce, 34.3, 1179–1214: por lo visto es principalmente inferencial y, en menor medida, reportativo en la escritura formal. En contraste con los géneros orales, tiende a introducir inferencias genéricas, y en ocasiones también precede conjeturas. Se alinea con el parámetro de la objetividad, permitiendo al emisor mostrar una menor implicación hacia la evidencia, así como un mayor compromiso epistémico hacia la fiabilidad de la información. Se ve que, por el contrario, es generalmente un marcador inferencial, tanto en géneros escritos como orales. Se emplea, principalmente, para encabezar inferencias conjeturales. Con se ve que, el emisor muestra una mayor implicación y subjetivización, y un menor compromiso epistémico hacia la evidencia que se introduce en el discurso. Los diferentes patrones de comportamiento discursivo exhibidos por ambos evidenciales pueden explicarse en el marco de la teoría argumentativa del razonamiento (Mercier, H. y Sperber, D. (2011). Why do humans reason? Arguments for an Argumentative Theory. Behavioral and Brain Sciences, 34.2, 57–74; Mercier H. y Sperber, D. (2017). The Enigma of Reason. Cambridge, Mass.: Harvard University Press.). Por lo visto y se ve que tienden a introducir, respectivamente, conclusiones intuitivas y reflexivas que deben ser verificadas y aceptadas por la audiencia. Se ve que apunta, generalmente, a la activación de los mecanismos cognitivos de vigilancia epistémica y lectura de la mente, mientras que por lo visto tiende a desencadenar los procesos de vigilancia epistémica y de razonamiento. (shrink)

American physicians are increasingly concerned that they are losing professional control. Other analysts of medical power argue that physicians have too much power. This essay argues that current analyses are grounded in a structuralist reading of power. Deploying Michel Foucault's "care of the self" and rhetorician Raymie McKerrow's "critical rhetoric," this essay claims that medical power is better understood as a way that medical actors take on power through rhetoric rather than a force that has power over medical actors. Through (...) a close reading of an essay by Senator Bill Frist, this paper argues that physicians experience a process of "subjection" wherein they are both agents of and objects of medical power as it is combined with state and corporate power in the American "war on terror." This alternative mode of analyzing medical power has implications for our collective understanding of its operations and the means by which we propose alternative enactments of medical power. (shrink)

Each volume of this series of Companions to major philosophers contains specially-commissioned essays by an international team of scholars, together with a substantial bibliography, and will serve as a reference work for students and non-specialists. The contributors to this Companion probe the full depth of Kierkegaard's thought revealing its distinctive subtlety. The topics covered include Kierkegaard's views on art and religion, ethics and psychology, theology and politics, and knowledge and virtue. Much attention is devoted to the pervasive influence of Kierkegaard (...) in twentieth-century philosophy. New readers will find this the a convenient and accessible guide to Kierkegaard. Advanced students and specialists will find a conspectus of recent developments in the interpretation of Kierkegaard. (shrink)

Marie-Therese d'Alverny devoted a large part of her research to discovering and describing manuscripts of scientific texts, especially those translated from Arabic. This volume contains those of d'Alverny's studies devoted to the Latin transmission of the works of other Greek and Arabic authors (Aristotle, Galen, Priscianus Lydus, al-Kindi, Albumasar, Algazel and Averroes), the authors responsible for this transmission (Scotus Eriugena, Raymond of Marseilles, Petrus Hispanus, Henri Bate of Malines and Pietro d'Abano), and some of the themes of the transmitted texts (...) (astrology and the planetary system of Herclides), as well as three articles summarizing the whole transmission process. (shrink)

_A unique philosophical look at the hit television series _Downton Abbey_ _ Who can resist the lure of _Downton Abbey_ and the triumphs and travails of the Crawley family and its servants? We admire Bates's sense of honor, envy Carson's steadfastness, and thrill to Violet's caustic wit. _Downton Abbey and Philosophy_ draws on some of history's most profound philosophical minds to delve deeply into the dilemmas that confront our favorite characters. Was Matthew right to push Mary away after his (...) injury in the war? Would Lord Grantham have been justified in blocking Lady Sybil's marriage to Tom Branson? And is Thomas really such a bad person? Offers fresh and intriguing insights into your favorite _Downton Abbey_ characters, plot lines, and ideas Addresses many of your most pressing questions about _Downton Abbey's_ story and characters, such as: Should Daisy have lied to William about her feelings toward him—especially to the point of marrying him? Should Mr. Bates have been upfront with Anna from the beginning about his past? Views _Downton Abbey_ through the lens of some of the most influential philosophical thinkers, from Saint Augustine and David Hume to Immanuel Kant and John Stuart Mill Ventures upstairs _and_ downstairs to examine key themes involving ethics, virtue, morality, class, feminism, the human condition, and more Philosophical speculation awaits on every page of this essential _Downton Abbey_ companion. So take a seat in your personal library, have the butler pour a cup of tea, and start reading! (shrink)

Henri Bate de Malines a développé dans son Speculum divinorum une théorie de l’intellect profondément influencée par Averroès et Thomas d’Aquin, mais qui ne peut être considérée ni comme averroïste ni comme thomiste. Dans sa perspective néoplatonicienne, l’intellect agent est la forme immanente et transcendante du corps humain, tandis que l’intellect possible est un étant relatif et privatif.

We fear that the growing threat of violent attack has upset the balance between existential concepts of political power, which emphasize security, and traditional notions of constitutional limits meant to protect civil liberties. We worry that constitutional states cannot, during a time of war, terror, and extreme crisis, maintain legality and preserve civil rights and freedoms. David Williams Bates allays these concerns by revisiting the theoretical origins of the modern constitutional state, which, he argues, recognized and made room for (...) tensions among law, war, and the social order. We traditionally associate the Enlightenment with the taming of absolutist sovereign power through the establishment of a legal state based on the rights of individuals. In his critical rereading, Bates shows instead that Enlightenment thinkers conceived of political autonomy in a systematic, theoretical way. Focusing on the nature of foundational violence, war, and existential crises, eighteenth-century thinkers understood law and constitutional order not as constraints on political power but as the logical implication of that primordial force. Returning to the origin stories that informed the beginnings of political community, Bates reclaims the idea of law, warfare, and the social order as intertwining elements subject to complex historical development. Following an analysis of seminal works by seventeenth-century natural-law theorists, Bates reviews the major canonical thinkers of constitutional theory (Locke, Montesquieu, and Rousseau) from the perspective of existential security and sovereign power. Countering Carl Schmitt's influential notion of the autonomy of the political, Bates demonstrates that Enlightenment thinkers understood the autonomous political sphere as a space of law protecting individuals according to their political status, not as mere members of a historically contingent social order. (shrink)

Glitch composition is a meta-discursive practice: rather than writing new music inspired by older recordings, it constructs new music inspired by the technological conditions and limitations in which those recordings emerged. For those listeners who aren’t particularly interested in technology theories, such music is particularly alienating—an in-joke that one doesn’t get. When glitch becomes pop, it loses its theoretical savvy, replacing the “synth pad” in a contemporary pop song. Glitch’s subversion of the bad value judgment placed on damaged media is (...) only a partial one—as scratched CDs (whether they be glitch ones or not) remain economically worthless commodities. (shrink)

Complex responsive processes theory is utilised in an original way to critique leadership myths and explore the alternative, deeper meanings of educational transformation. The theory opens up new forms of understanding about how ordinary practitioners negotiate the meanings of 'improvement' in their everyday practice. It is in the gap between the emergence of these local interactions and the predetermined designs of policy-makers that educational transformation can be lost or found.--.

Aeschylus’ Oresteia supports Aristotle’s claim about the naturalness of the city and the city’s role in shaping justice for humans. In the Oresteia, Aeschylus shows how the city’s justice is the only way to control the wrath of the Furies. Aeschylus shows that the city and its justice tames the Furies and provides for the only way by which the husband-wife relation, which is not a blood tie but provides the basis for which the family is even possible, can be (...) preserved and be secure from the passions the Furies release in their quest for revenge. The Furies and their desire for vengeance for the violation of the blood bond, threaten to undermine the very basis on which the family is founded: the husband-wife bond. Thus Aeschylus gives support and aids Aristotle’s position that the husband-wife bond is a political bond and rests within the realm of the city and the political. (shrink)

Workplace ethics perceptions drive ethical behaviors, but our understanding of how context shapes the nature of this relationship is limited. Consequently, this article uses contingency theory to explore how perceptions of ethical priorities in the workplace—ethical work climate (EWC)—are differentially associated with ethical behavior based on the broader context. Specifically, we meta-analytically test theoretically relevant cultural values (i.e., collectivism, power distance) and work context factors (i.e., consequence of errors, job autonomy) as moderators of the connection between EWC perceptions and ethical (...) behavior. Our findings reveal that while higher power-distance societal contexts strengthen the connection between EWC perceptions and ethical behavior, work contexts with higher autonomy _weaken_ the connection. We found mixed support for collectivism as a contextual moderator, with results supporting theoretical expectations with one cultural conceptualization but not another. Contrary to expectations, the consequences of errors in work contexts did not moderate the association between EWC perceptions and ethical behavior. Taken together, this meta-analytic investigation highlights the meaningful role of the broader organizational context as a potential boundary condition for the influence of EWC perceptions on ethical behavior. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Ideas 61.4 (2000) 577-593 [Access article in PDF] Machina Ex Deo: William Harvey and the Meaning of Instrument Don Bates Introduction Since our clocks do consistently disclose each hour of the day and night--do they not seem to partake of another body (beyond the elements), and that more divine? But if, under the dominion and management of [our human] Art, such splendid things (...) are daily achieved beyond the powers of the objects themselves,... And if, in serving men they carry out such things as are to be marvelled at, what I ask, may we expect from them when they be instruments in the hand of God? These words come near the end of William Harvey's De generatione animalium. 1 As he does often in this work, he is arguing that it is possible for a material object to behave supra vires elementorum, i.e., in a manner that exceeds what can be explained merely from the qualities of the elements from which it is made. In fact, just before this, he argues that human craftsmanship enables the elements of air and water to make ships sail in opposite directions, fire to do one sort of thing in the kitchen, another in the shops of metal-workers, including the production of iron, which in its turn peacefully tills the soil or besieges the town in war. So if even human Art is capable of making something as wonderful as a clock out of the elements, how much more might God be able to do with them? [End Page 577]Not only is it entirely conceivable that the (divinely) artful manipulation of these same elements can account for the wonders of God's nature--such as the generation of a chick out of an egg--there is also no need to infer the existence of additional entities such as faculties, qualities, agents, and the like. All that is needed is the concept of "instrument." Today such things as his appeal to a clock, his reference to "art," and the word "instrument" itself, are liable to arouse in our minds a fairly mechanical sort of image. Therefore, we need to put this idea in its intellectual context, by looking at where Harvey's notion of instrument is coming from.First, our much more mechanical world view was just coming into being as Harvey (1578-1657) wrote these words. Although the philosophy of his younger contemporary, René Descartes (1596-1650) was not yet in full bloom (he died a year before Harvey's book appeared), Cartesianism was certainly on the explanatory horizon, 2 as was the work of another contemporary and contributor to the "new philosophy," Pierre Gassendi (1592-1655). 3 And, of course, Harvey had certainly known Francis Bacon (1561-1626). 4 Nevertheless, Harvey was a devout Aristotelian who was adamantly opposed to the efforts of these contemporaries to replace Aristotle. 5 Moreover, it was from the Aristotelian tradition, not from the new mechanics, that Harvey had derived the concept of instrument.If, broadly speaking, the "new philosophy" was about a universe that was built like a clock, then the "old" natural philosophies, whether dominated by Platonism, Aristotelianism, Christian theology, or some combination, were about a universe that was socially constructed. 6 Not only was man at the center, to a large extent the workings of the universe were envisioned in terms of social experience. The regularity, predictability, harmony, and wonder of natural phenomena seemed best explained in the language of reason, moral values, motives, responsibilities, hierarchies, laws (in the social sense), and the like, explanatory resources that, in the late ancient and medieval intellectual cultures of Europe, far outweighed either those that appealed to the passively material and the mechanical, or to the random and the chance.But very central to that social model of nature was the concept of instrument, which gave to it something of a mechanical twist. To see how this was so, we need to go back temporarily to the works of Aristotle, the influence of... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Philosophy 43.1 (2005) 83-105 [Access article in PDF] Does Malebranche Need Efficacious Ideas? The Cognitive Faculties, the Ontological Status of Ideas, and Human Attention Susan Peppers-Bates But whatever effort of mind I make, I cannot find an idea of force, efficacy, of power, save in the will of the infinitely perfect Being. Malebranche, Elucidation 15 One of the signatures of 17th century rationalists (...) is their replacement of the Scholastics's dependence on the deliverances of the senses with a dependence on the deliverances of the intellect as the key to gaining knowledge.1 Correct use of the intellect leading to freedom from the passions and to certain knowledge figures prominently in the works of Spinoza and Leibniz. Descartes's Meditations uses skeptical doubt to withdraw the mind from the senses, and his reliance on the meditative genre not only reveals to his readers the intellect as a distinct source of knowledge, but also trains them to use properly their will or faculty of judgment. Commentators have argued persuasively that overthrowing the sense-based epistemology and metaphysics of the Aristotelians depended on "discovering" the primacy of one's intellect over the senses, and using the deliverances of the mind to establish solid foundations for a new metaphysics and epistemology.2 Indeed, [End Page 83] outlining the proper use of the mind's faculties arguably lay at the basis of the Cartesian program in particular. This importance can be seen in Arnauld and Nicole's influential Port-Royal Logic, which aimed at training its readers in the proper use of the intellect.3Few would question Nicolas Malebranche's inclusion in the rationalist tradition.4 For while Malebranche famously takes ideas out of the Cartesian mind and transports them to God's—thus privileging the divine over the natural light—he shares Descartes's belief that our intellect, not our senses, holds the key to metaphysical truths such as the essence of matter, the mind-body distinction, and the existence of God.5 Yet, recently, Nicholas Jolley has contended that Malebranche's later commitment to "efficacious ideas" undermines his earlier belief in the power of the cognitive faculties: he believes that Malebranche abandons his view that the mind makes "real use" of the intellect to know intelligible objects.6 Jolley's position builds upon Alquié and Robinet's claims that around 1694-95 Malebranche moved from a vision "in" God to a vision "by" God. Now God's ideas act on and modify the soul with both sensations and intellectual concepts, rather than the human intellect contemplating ideas in the Divine Reason.7Alquié and Robinet argue that Malebranche, pushed by the battles with Arnauld and Régis over the status of ideas, introduced the language of "efficacious" ideas to explain how the union of the human and the divine mind is supposed to work.8 Robinet in particular suggests that in cashing out the metaphor of God enlightening human minds, Malebranche moved from a static "ontologist" view of idea-objects in God to an active "illuminationist" view whereby divine ideas cause(intellectual [End Page 84] and sensory) perception by modifying the soul.9 Once one accepts this view of the place and function of efficacious ideas in Malebranche's metaphysics, it seems natural to accept Jolley's declaration that the only way for the mind to apprehend ideas in God is if those ideas "act directly on the mind; [if] they thereby cause cognitive states to arise in a substance which is devoid of all genuine cognitive capacities of its own."10 Indeed, Jolley suggests that Malebranche ultimately made the soul passive in all its states, including its volitional ones.11In this paper, I argue that a strong interpretation of efficacious ideas, whereby they appear to become true causal agents, must be rejected precisely because it pushes us into an incorrect reading of Malebranche's theory of the divine and human faculties. Making ideas true causal agents within God privileges divine reason at the... (shrink)

Malebranche's metaphysics and the problem of human freedom -- God, order, and general volitions -- Arnauld and Malebranche on the power of the human intellect -- The cognitive faculties and the divine ideas -- Malebranche on free will and imminent causation.

Despite ideals of philosophical objectivity, who speaks is as important as what is said, and those who fall outside the Eurocentric male norm often are not heard or invited to participate in theorizing. New work chronicling and challenging the creation of white supremacist ideology in philosophy is needed greatly. In this important book, Another Mind-Body Problem: A History of Racial Non-Being, John Harfouch reveals the hermeneutical injustice that obscures how professional philosophers understand the mind-body problem today and how the terms (...) of that problem were created in the early modern period. Unlike the puzzle of causal relations between the mind and body canonized by white philosophers... (shrink)

In this paper I will argue that a false assumption drives the attraction of philosophers to a divine command theory of morality. Specifically, I suggest the idea that anything not created by God is independent of God is a misconception. The idea misleads us into thinking that our only choice in offering a theistic ground for morality is between making God bow to a standard independent of his will or God creating morality in revealing his will. Yet what is God (...) is hardly independent of him, and in coupling a perfect being theology with the doctrine of divine simplicity we discover that God’s “reason” is God. Accordingly, obeying the truths of goodness that we humans speak of as contained in the divine wisdom hardly impugns the divine sovereignty. By modifying divine command ethics to give primacy to God’s love or justice, thinkers such as Robert M. Adams, Philip L. Quinn, and Edward J. Wierenga admit the repugnance of this picture in spite of their verbal allegiance to divine command ethics. Accordingly, they implicitly concede that basing morality on God’s sheer power should not be the preferred option for the Christian theist. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Ethics & the Environment 8.2 (2003) 126-131 [Access article in PDF] Three Challenges to Ethics, by James Sterba. Oxford University Press, 2000. Paperback, pp. 160. ISBN: 0195124766. $14.95. In Three Challenges to Ethics, James Sterba's central claim is that environmentalism, feminism, and multiculturalism challenge traditional Western ethics, as exemplified by Aristotelian, Kantian, and utilitarian moral theory. Sterba understands these views respectively as the claims that Western ethics is biased (...) against non-human creatures, women, and non-Western cultures. If taken seriously, these schools of thought require making adjustments in our concepts of what sorts of things can have goods or interests, who is rational, and what sorts of intuitions get counted among the data we examine. Sterba offers a decisive argument for giving these views a fair hearing. He argues that to dismiss these views without a fair hearing is to beg the question in favor of the accepted views.There are two primary projects that run through this book. The first project examines whether or not entire groups of people or categories of thought can be dismissed. The second project shows that particular schools of thought and individual thinkers challenge traditional ethics by examining the important contributions they make. [End Page 126]The views of women, non-white, and non-Western thinkers have been and are frequently dismissed prior to any hearing (sometimes by relying on historically dated and biased hearings) on the assumption that only white men of European descent can make meaningful contributions to Western culture. It isn't unusual for people who hold this view to point to the historical absence of contributions from women or non-whites as evidence for their inability to contribute. When a few representatives are brought forth, it is claimed that these few exceptions actually prove the rule. Without real evidence that shows that, as a rule, particular categories of people cannot make contributions to the discussion (which seems a priori false, if anything does), we have both a moral and intellectual obligation to take all people and positions seriously. His discussion of whether or not to take environmentalism, feminism, and multiculturalism seriously is framed by the straightforward concern about whether or not those who reject these problems, thinkers, and ideas as genuine or legitimate are begging the question in favor of their own position. He shows decisively that if those who work in this area and who do intellectual work generally do not want to be accused of begging the question with regard to these issues, then they must assess these positions and the corresponding work on a par with the work of Western male philosophers. By holding ourselves accountable to our own standards, we are obligated to give even possibly unpromising views a fair hearing, a hearing on a par with positions we favor. Using the standards of Western reasoning, we must provide evidence that these positions are inherently worthless in order to dismiss them wholesale or at the very least reasons to dismiss individual thinkers. In order to do this, we must begin by evaluating these positions fairly.Having made this case, Sterba moves on to show that there is good evidence to take these various challenges and the particular challengers seriously. In the first chapter of the book Sterba discusses the challenge posed to traditional ethics by relativism, and having shown that there are at least good reasons for rejecting relativism, goes on to discuss the demands of morality. He also has a concise introduction to the ideas of Aristotle, Kant, and utilitarianism.The rest of the book addresses the three challenges, first by presenting an introduction to the particular challenge, which is both brief and detailed, and then showing how each set of criticisms can be accommodated by moral theory. He discusses, arguably, the three most important moral positions, Aristotle, Kant, and the utilitarians, along with their traditional [End Page 127] responses. He then goes on to show how the challenges to traditional ethics can be accommodated, largely by Kantian ethics. Because of the brevity of the book, some background might be required if this book is used in introductory courses... (shrink)

This study described the relationships between academic class and student moral sensitivity and reasoning and between curriculum design components for ethics education and student moral sensitivity and reasoning. The data were collected from freshman (n = 506) and senior students (n = 440) in eight baccalaureate nursing programs in South Korea by survey; the survey consisted of the Korean Moral Sensitivity Questionnaire and the Korean Defining Issues Test. The results showed that moral sensitivity scores in patient-oriented care and conflict were (...) higher in senior students than in freshman students. Furthermore, more hours of ethics content were associated with higher principled thinking scores of senior students. Nursing education in South Korea may have an impact on developing student moral sensitivity. Planned ethics content in nursing curricula is necessary to improve moral sensitivity and moral reasoning of students. (shrink)