The introduction of Western healthcare, via colonialism, into Africa facilitated a confrontation of indigenous and exogenous “medical” knowledge as well as the attendant praxis. Although colonialism has been expunged from the shores of Africa, the epistemic and ideological frictions it introduced into the sphere of healthcare linger and raise different dilemmas. Against this background, this paper explores pragmatic and ethical approaches that may help engage these tensions in the context of drug development based on validated traditional phytomedicines.

Many drugs used in paediatric medicine are off-label. There is a rising call for the use of adaptive clinical trial designs in responding to the need for safe and effective drugs given their potential to offer efficiency and cost-effective benefits compared with traditional clinical trials. ADs have a strong appeal in paediatric clinical trials given the small number of available participants, limited understanding of age-related variability and the desire to limit exposure to futile or unsafe interventions. Although the ethical value (...) of adaptive trials has increasingly come under scrutiny, there is a paucity of literature on the ethical dilemmas that may be associated with paediatric adaptive designs. This paper highlights some of these ethical concerns around safety, scientific/social value and caregiver/guardian comprehension of the trial design. Against this background, the paper develops a non-static conceptual lens for understanding PADs. It shows that ADs are epistemically open and reduce some of the knowledge-associated uncertainties inherent in clinical trials as well as fast-track the time to draw conclusions about the value of evaluated drugs/treatments. On this note, the authors argue that PADs are ethically justifiable given they have multiple layers of safety, exposing enrolled children to lesser potential risks, create social/scientific value generally and for paediatric populations in particular, specifically foster the flourishing of paediatric populations and can significantly improve paediatric trial efficiency when properly designed and implemented. However, because PADs are relatively new and their regulatory, ethical and logistical characteristics are yet to be clarified in some jurisdictions, the cooperation of various public and private stakeholders is required to ensure that the interests of children, their caregivers and parents/guardians are best served while exposing paediatric research subjects to the most minimal of risks when they are enrolled in paediatric trials that use ADs. Data sharing not applicable as no datasets generated and/or analysed for this study. Not applicable. (shrink)

Volume 19, Issue 7, July 2019, Page 53-55.

Funding broadly connotes the notion of an institution and/or institutions making money and other resources available to individual researchers and organizations to accomplish specific projects. Whi...

Contexts where the same clinician with an ongoing physician-patient relationship seeks to enroll his or her own patient(s) into a clinical research are ethically tricky due to the associated role c...

The power of the scientific enterprise presents multiple avenues for harnessing and increasingly controlling biological phenomena and instituting interventions in different areas of biomedicine (Af...

One of the central characteristics of public health disasters is the rapid overlapping of different needs and priorities that require making critical choices that inevitably elicit conflicti...

Pragmatic clinical trials (PCTs) seek to show the effectiveness of treatments in routine, clinical practice (MacPherson 2004). However, a number of ethical challenges come to the fore when collater...

Volume 20, Issue 2, February 2020, Page 38-41.

The central aim of Hegel's' social philosophy (the Rechtsphilosophie) is to reconcile his contemporaries--the men and women of the nineteenth century--to the modern social world. By "the modem social world" I mean the central social institutions of that era: the family, civil society, and the state. Hegel seeks to enable his contemporaries to overcome their alienation from this world by providing them with a philosophical theory that will reveal its true nature (PR, Preface sec. 14). "The project of reconciliation" is (...) the name I have given to this enterprise. My aim in this article is to introduce Hegel's project. I shall neither attempt to present the project nor attempt to assess it. My aim is simply to explain what the project is. I begin by considering the problem the project addresses and the sort of solution it proposes, and devote the remainder of the article to an examination of the project's goal. (shrink)

Joshua Glasgow has written a wonderful book on race (Glasgow 2009). Thoughtful, clear, and provocative, it advances the discussion in significant ways. Space is limited so I hope I can be excused for restricting my comments to Glasgow’s assessment of my 2003 Journal of Philosophy analysis of the ordinary concept of race. The last thing I would want to suggest is that this exhausts the interest of his book; for that is certainly not the case. My remarks can be regarded (...) as testimony to just how stimulating his fine account is. (shrink)

Where exactly did Hegel go wrong on race? Moellendorf helpfully tells us that Hegel's treatment of race begins systematically in the Philosophy of Subjective Spirit and that he went wrong philosophically in the use of the biological category of race. This is basically correct but requires precisification. This article considers why Hegel's category of race is not unambiguously biological. Race's biological status can be problematized from the standpoint of contemporary biology and from the standpoint of Hegel's system. The textual placement (...) of Hegel's systematic discussion of race in the philosophy of spirit makes clear that Hegel conceived of race in spiritual terms. Hegel took race to be a biospiritual category. Hegel was clearly committed to the now-controversial proposition that there is such a thing as human biological race, that there is a plurality of biological human races. He regarded race as a robust natural kind. His preferred list of races includes Caucasians, Negros, Mongolian, Malaysians and Americans. One noteworthy feature of his understanding of race's physical aspect was his focus on the formation of the skull and the face. At the same time, he clearly held that there were other deeper physical differences that accounted for the spiritual differences of race. Hegel was perfectly clear that race has a spiritual as well as physical aspect. He held that that the members of racial groups essentially shared certain fundamental, heritable, moral, intellectual and cultural characteristics with one another that they did not share with members of any other race and that these differences were such as to support an objective ranking. This shows that Hegel took the category of race to be the sort of category we today would characterize as ‘racialist’. Hegel's concept of race was the racialist concept of race. (shrink)

Kierkegaards deiktische Theologie wird in einer Reihe von Textinterpretationen entwickelt, die seine oft übersehenen erbaulichen Reden in einem neuen Licht präsentieren. Das Buch setzt sich mit dem traditionellen Bild der Religiosität bei Kierkegaard auseinander, wie sie in den Begriffen der Religiosität A und B zum Ausdruck kommt, und bringt neue Argumente im Sinne einer deiktischen Theologie. Sie wird in einer doppelten Perspektive entfaltet: Der Mensch richtet seinen Blick auf Gott - und Gott begegnet ihm, indem er den Menschen auf seinen (...) Nächsten hinweist. Deiktische Theologie ist weder eine Schöpfungstheologie (Religiosität A) noch eine Offenbarungstheologie (Religiosität B), sondern sie erfasst die Spannung zwischen Schöpfung und Offenbarung, die u.a. im trinitarischen Gottesbegriff begründet wird. Die Entwicklung der deiktischen Theologie Kierkegaards geschieht in der Interpretation zentraler Texte aus den erbaulichen Reden, der Einübung im Christentum sowie der Unwissenschaftlichen Nachschrift. Wichtige Themen sind darüber hinaus: die Zeitlichkeit, das Verhältnis zwischen dem Humanen und dem Christlichen, die Reue, die Sünde, das Abendmahl, das Leiden, die Nachfolge Christi, Himmelfahrt und Auferstehung. (shrink)

Throughout his career, Wittgenstein was preoccupied with issues in the philosophy of perception. Despite this, little attention has been paid to this aspect of Wittgenstein's work. This volume redresses this lack, by bringing together an international group of leading philosophers to focus on the impact of Wittgenstein's work on the philosophy of perception. The ten specially commissioned chapters draw on the complete range of Wittgenstein's writings, from his earliest to latest extant works, and combine both exegetical approaches with engagements with (...) contemporary philosophy of mind. Topics covered include: perception and judgement in the _Tractatus _ aspect-perception the putative intentionality of perception representationalism. The book also includes an overview which summarises the evolution of Wittgenstein's views on perception throughout his life. With an outstanding array of contributors, _Wittgenstein and Perception_ is essential reading for students and scholars of Wittgenstein’s work, as well as those working in philosophy of mind and philosophy of perception. Contributors: Yasuhiro Arahata, Michael Campbell, William Child, Daniel Hutto, Michael O’Sullivan, Marie McGinn, Michel terHark, Charles Travis, and José Zalabardo. (shrink)

This book offers an examination of the political and ontological significance of the authorship of Søren Kierkegaard in relation to German Idealism and contemporary European philosophy.

An incoherent visualization is when aspects of different senses of a word are present in the same visualization. We describe and implement a new model of creating contextual coherence in the visual imagination called Coherencer, based on the SOILIE model of imagination. We show that Coherencer is able to generate scene descriptions that are more coherent than SOILIE's original approach as well as a parallel connectionist algorithm that is considered competitive in the literature on general coherence. We also show that (...) co-occurrence probabilities are a better association representation than holographic vectors and that better models of coherence improve the resulting output independent of the association type that is used. Theoretically, we show that Coherencer is consistent with other models of cognitive generation. In particular, Coherencer is a similar, but more cognitively plausible model than the C3 model of concept combination created by Costello and Keane. We show that Coherencer is also consistent with both the modal schematic indices of perceptual symbol systems theory and the amodal contextual constraints of Thagard's theory of coherence. Finally, we describe how Coherencer is consistent with contemporary research on the hippocampus, and we show evidence that the process of making a visualization coherent is serial. (shrink)

Adrian Johnston is well known for his work at the intersection of Lacanian psychoanalysis, German idealism, contemporary French philosophy and most recently cognitive neuroscience. In the context of the current issue, Johnston represents the most complete development of a contemporary theory of Transcendental Materialism. In the following interview we explore both the implications of Johnston’s previous work, as well as the directions his most recent projects are taking.

It argues that states forge a relationship due to strategic needs such as economic or security needs. Slobodchikoff has developed a database composed of the whole population of bilateral treaties between Russia and each of the former Soviet republics, and examines all of these bilateral relationships. He finds that Russia indeed forged relationships with the former republics based on its strategic interests. However, despite Russia's strategic interests, it had to build a bilateral relationship that would address the issues of mistrust (...) and power asymmetry between the states. To achieve this, Russia and the former Soviet republics created treaty networks, which served to legitimize as well as legalize the independent status of each of the former republics while also increasing the cost to Russia of violating any of the treaties. (shrink)

In this author-meets critics discussion of Howard Thurman’s Philosophical Mysticism, Anthony Sean Neal argues that Thurman’s work requires systematic recognition of how he was rooted firmly within the Modern Era of the African American Freedom Struggle (1896–1975). Michael Barber suggests that Thurman may be understood in contrast to Levinas on two counts. Whereas Thurman develops the duty to love from within the one who must love, Levinas grasps the origin of love’s duty in the command of the one who (...) is to be loved. And while Thurman’s mysticism yearns for oneness, Levinas warns that oneness is ethically problematic. Eddie O'Byrn challenges the symbolic validity of calling love a weapon, and asks why the book has not treated Thurman’s relations to Gandhi or King. Neal defends a provisional usage of the term weapon in relation to love and offers some preliminary considerations of Thurman’s relation to Gandhi and King, especially in the symbolic significance of "the dream.". (shrink)

This book assesses how Vatican II opened up the Catholic Church to encounter, dialogue, and engagement with other world religions. Opening with a contribution from the President of the Pontifical Council for Interreligious Dialogue, Cardinal Jean-Louis Tauran, it next explores the impact, relevance, and promise of the Declaration Nostra Aetate before turning to consider how Vatican II in general has influenced interfaith dialogue and the intellectual and comparative study of world religions in the postconciliar decades, as well as the contribution (...) of particular past and present thinkers to the formation of current interreligious and comparative theological methods. Additionally, chapters consider interreligious dialogue vis-à-vis theological anthropology in conciliar documents; openness to the spiritual practices of other faith traditions as a way of encouraging positive interreligious encounter; the role of lay and new ecclesial movements in interreligious dialogue; and the development of Monastic Interreligious Dialogue. Finally, it includes a range of perspectives on the fruits and future of Vatican’s II’s opening to particular faiths such as Judaism, Islam, Hinduism, and Buddhism. (shrink)

The nature and worth of Michael Oakeshott’s contribution as a political thinker have long been the subject of deep disagreement within the community of Anglophone political theory. This is partly the product of a partial familiarity with Oakeshott’s corpus. During his lifetime, his body of published work had a rather slender appearance, comprising two major monographs, separated by some forty years, and two rather more accessible collections of essays on politics and history. Following his death in 1990, however, a (...) much larger body of writings has become available. In particular, with the publication of his Notebooks, we are afforded the chance to form a nuanced and informed understanding of how the thinking in his texts interconnected, and to appreciate the range of intellectual influences and political preoccupations that characterised his work. (shrink)

The power of technology to transform religions, science, and political institutions has often been presented as nothing short of revolutionary. Does technology have a similarly transformative influence on societies’ morality? Scholars have not rigorously investigated the role of technology in moral revolutions, even though existing research on technomoral change suggests that this role may be considerable. In this paper, we explore what the role of technology in moral revolutions, understood as processes of radical group-level moral change, amounts to. We do (...) so by investigating four historical episodes of radical moral change in which technology plays a noteworthy role. Our case-studies illustrate the plurality of mechanisms involved in technomoral revolutions, but also suggest general patterns of technomoral change, such as technology’s capacity to stabilize and destabilize moral systems, and to make morally salient phenomena visible or invisible. We find several leads to expand and refine conceptual tools for analysing moral change, specifically by crystallizing the notions of ‘technomoral niche construction’ and ‘moral payoff mechanisms’. Coming to terms with the role of technology in radical moral change, we argue, enriches our understanding of moral revolutions, and alerts us to the depths of which technology can change our societies in wanted and unwanted ways. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Review Essay:Aquinas, Modern Theology, and the TrinityGuy Mansini O.S.B.As one would expect from his Incarnate Lord, Thomas Joseph White's Trinity is no exercise in historical theology, although of course it calls on history, but aims to give us St. Thomas's theology as an enduring and so contemporary theology that both respects the creedal commitments of the Catholic Church and offers a more satisfying understanding of the Trinity than anything (...) proposed by the great theologians, Catholic and Protestant, of the past hundred years.1 The Trinity, however, gives a more complete and satisfying view of its subject than does The Incarnate Lord.Can St. Thomas really be fruitfully located within the dialectic of nineteenth- and twentieth-century Trinitarian speculation? Yes, and it is one of White's principal contributions to show how St. Thomas's medieval contemporaries, the early Franciscans on the one hand and William of Ockham on the other, remotely but really adumbrate nineteenth- and twentieth-century theological positions, once due attention is paid to the key issues of the analogical naming of God and his knowability. The reader is thus assured that Aquinas's original project was composed with some awareness of temptations and alternatives repeated (though not exactly, of course) in modern thought. It should be added that St. Thomas is by no means treated as the only systematic theological authority for Trinitarian theology, but White recognizes his paradigmatic place in the Catholic theological tradition. [End Page 1415]The most important issue for assessing the enduring value of Thomas's Trinitarian theology, then, whether in the thirteenth century or twentieth century, turns out to be the applicability and centrality of the psychological analogy for an understanding of the immanent intelligibility of the Trinity, an analogy suggested by Scripture, and developed by the Cappadocians, St. Augustine, St. Thomas, and other medieval writers, not to mention John Henry Newman and Matthias J. Scheeben.What is the status of this analogy? Olivier-Thomas Venard laconically describes it as "revealed"—too hot. Michael Maria Waldstein has recently argued vigorously and at length that it is not revealed at all—too cold. White does not discuss this in detail but is satisfied with saying that it is "derived" from Scripture—just right. However one thinks this question is to be resolved, White robustly defends the psychological analogy as a proper analogy and as the only systematic theological instrument ever offered by the theological tradition that succeeds in providing real understanding of the immanent life of the Trinity, one that preserves the transcendence of God and honors the dogmatic tradition of the Church bearing on the nature of God and the Trinity of persons—Nicaea, Lateran IV, and Vatican I, especially. This is how he does it in chapter 22.1. We know the mystery of interior Trinitarian life based on God's manifestation of it to us in the economy of salvation via the missions of Word and Spirit, which disclose to us distinct personal processions.2. Such processions are either immanent or transitive.3. But transitive processions terminate in some substance distinct from whence they emanate.4. God, however, is one in nature (essence, substance) both specifically and numerically.5. Therefore, the processions are immanent to the godhead.6. However, there are only two immanent immaterial activities known to us, that of knowing and that of loving.7. Therefore, we cannot have some understanding of the mystery of interior Trinitarian life except by analogy with these two [End Page 1416] activities. That is to say, we know the mystery of the Trinitarian life according to the "psychological model" or not at all.This argument can be re-phrased with more pointed reference to modern theologies of the Trinity.1. If we wish to understand the mystery of the immanent Trinitarian life of distinct persons, but not by way of immanent activities and processions, then we must appeal to transitive activity to account for the distinction of persons.2. Transitive divine activity can be conceived of (1) as creative, (2) as within creation relative to its history (the continental way), or (3) as taking place between three already constituted divine individuals, relating transitively to one... (shrink)

"O'Meara masterfully situates Pryzwara in relation to the traditional and contemporary theological, philosophical, ecclesial, cultural, and social contexts within which he wrote." --_William P. Loewe, professor of religious studies, Catholic University of America_ Erich Przywara, S.J. is one of the important Catholic intellectuals of the twentieth century. Yet, in the English-speaking world Przywara remains largely unknown. Few of his sixty books or six hundred articles have been translated. In this engaging new book, Thomas O'Meara offers a comprehensive study of the (...) German Jesuit Erich Przywara and his philosophical theology. Przywara's scholarly contributions were remarkable. He was one of three theologians who introduced the writings of John Henry Cardinal Newman into Germany. From his position at the Jesuit journal in Munich, _Stimmen der Zeit_, he offered an open and broad Catholic perspective on the cultural, philosophical, and theological currents of his time. As one of the first Catholic intellectuals to employ the phenomenologies of Edmund Husserl and Max Scheler, he was also responsible for giving an influential, more theological interpretation of the Spiritual Exercises of Ignatius Loyola. Przywara was also deeply engaged in the ideas and authors of his times. He was the first Catholic dialogue partner of Karl Barth and Paul Tillich. Edmund Husserl was counted among Przywara's friends, and Edith Stein was a close personal and intellectual companion. Through his interactions with important figures of his age and his writings, ranging from speculative systems to liturgical hymns, Przywara was of marked importance in furthering a varied dialogue between German Catholicism and modern culture. Following a foreword by Michael Fahey, S.J., O'Meara presents a chapter on Pryzwara's life and a chronology of his writings. O'Meara then discusses Pryzwara's philosophical theology, his lecture-courses at German universities on Augustine and Aquinas, his philosophy of religion, and his influence on important intellectual contemporaries. O'Meara concludes with an in-depth analysis of Pryzwara's theology, focusing particularly on his Catholic views of person, liturgy, and church. (shrink)

Murga porteña, the satirical street theatre tradition associated with Carnival in Buenos Aires, Argentina, is historically a strongly patriarchal institution. Prominent roles such as reciting poetry, singing, and playing percussion instruments have been reserved exclusively for men. As the feminist movement in Argentina has grown in visibility and importance in recent years, feminist murga participants disrupted these patriarchal patterns. Women murga performers have begun to use murga as a space for feminist practice, both by creating women-only organizations to learn murga (...) skills and by bringing feminist perspectives into mixed-gender murgas. Murgueras are engaged in a multifaceted feminist project that disrupts gendered patterns by building women-only spaces to develop competence in the performance of historically masculine skills such as percussion. Drawing on ethnographic participant-observation of murga events as well as in-depth interviews with key organizers at the confluence of murga and feminism, we explore the ways in which murga has provided the spaces and strategies for collective feminist engagement. Murgas have become important social institutions in which women are “undoing gender” and disseminating feminist perspectives, even as most members join them not as explicitly feminist institutions. (shrink)

Enhancing Communication & Collaboration in Interdisciplinary Research, edited by Michael O'Rourke, Stephen Crowley, Sanford D. Eigenbrode, and J. D. Wulfhorst, is a volume of previously unpublished, state-of-the-art chapters on interdisciplinary communication and collaboration written by leading figures and promising junior scholars in the world of interdisciplinary research, education, and administration. Designed to inform both teaching and research, this innovative book covers the spectrum of interdisciplinary activity, offering a timely emphasis on collaborative interdisciplinary work. The book’s four main parts focus (...) on theoretical perspectives, case studies, communication tools, and institutional perspectives, while a final chapter ties together the various strands that emerge in the book and defines trend-lines and future research questions for those conducting work on interdisciplinary communication. (shrink)

Elimination of state laws that preempt local antismoking ordinances is a national health objective. However, the tobacco industry and its supporters have continued to pursue statelevel preemption of local tobacco control ordinances as part of an apparent strategy to avoid the difusion of grassroots antismoking initiatives. And, an increasing number of challenges to local ordinances by the tobacco industry and persons supported by the tobacco industry are being decided in state supreme courts and courts of appeals. The outcomes of seemingly (...) similar cases about the validity of local smoke-free air ordinances vary signifcantly by state. This paper examines the common and unique aspects of the decisions and the potential implications of court rulings on preemption for future state tobacco control eforts and achievement of national health objectives around the elimination of preemption. Using a search strategy developed for the Centers for Disease Control and Prevention's State Tobacco Activities Tracking and Evaluation System, cases where a state or federal appellate level court made a fnding on the validity of a local smoke-free air ordinance or regulation were identifed in 19 states. In contrast to previous studies, we found that cases in approximately half of states were decided for local governments. We also found that across the states, courts were considering similar factors in their decisions including the extent to which: the local government possessed the authority to pass the ordinance, the ordinance conficted with the state constitution, and state statutes preempt the ordinance. (shrink)