It has been known for over a century that there is an afferent, as well as an efferent, component to the visceral-atonomic nervous system. Despite the fundamental importance of bodily afferent information- sometimes called interoception- to central nervous system control of visceral organ function, emotional-motivational processes, and dysfunction of these processes, including psychosomatic disorders, its role did not receive much attention until quite recently. This is the first comprehensive review of this topic and it covers both neurobiological and (...) psychobiological aspects. The author first defines the issue and gives an historical background starting with the James-Lange theory of emotion, and addresses learning and motivation, roots in Pavlovian conditioning research, and operant conditioning of visceral function. In the second section he reviews recent scientific findings in the neural basis of visceral perception and studies in cardiovascular-respiratory and alimentary interoception. Finally, he discusses several related areas of research and theory including drug state issues, interoception and psychiatric disorders, and bodily consciousness, and suggests directions for future investigation. The book will be of interest to scientists in neurobiology, psychology, and brain imaging, to indivuals in related clinical fields such as psychiatry, neurology, cardiology, gastroenterology, and clinical psychology, and to their students and trainees. (shrink)

My commentary on mcmahon addresses the fact that only peripheral data have been considered for explaining differential sensibility in somato- and viscerosensory systems. This fails to take it into account that central processing for visceral and somatic inputs is now known to depend on different functional pathways. My commentary on berkley points out that the hypothalamus-pituitary axis is more responsive to stress in females than in males.

In 1929 when Aurel Kolnai published his essay “On Disgust” in Husserl's ]ahrbuch he could truly assert that disgust was a "sorely neglected" topic. Now, however, this situation is changing as philosophers, psychologists, and historians of culture are turning their attention not only to emotions in general but more specifically to the large and disturbing set of aversive emotions, including disgust. We here provide an account of Kolnai’s contribution to the study of the phenomenon of disgust, of his general theory (...) of emotions and of the phenomenological methodology he employed in his work. (shrink)

BackgroundDepression is a serious mental disorder often accompanied by emotional and physiological disorders. Visceral fat index is the current standard method in the evaluation of visceral fat deposition. In this study, we explored the association between VAI and depression in the American population using NHANES data.MethodsA total of 2,577 patients were enrolled for this study. Data were collected through structured questionnaires. Subgroup analysis for the relationship between VAI and depression was evaluated using multivariate regression analysis after adjustment for (...) potential confounding factors.ResultsFor every 1 unit increase in VAI, the clinical depression increased by 14%. High VAI scores increased the highest risk of developing depression. Subgroup analysis demonstrated a strong and stable association between VAI and the development of depression.ConclusionOur study showed that depressive symptoms are associated with a high ratio of visceral adiposity index after controlling confounding factors. (shrink)

This paper is situated in the context of feminist poststructuralist debates around identity. In it, I argue that anti-essentialist accounts of identity, while they may displace, or at least call into question, the foundations of subjectivity, are no less likely to invoke a series of presuppositions with respect to the self than those who seek to maintain them in some form. In particular, these presuppositions often cohere around the materiality of the body. And yet, paradoxically, this accent on materiality refers (...) to a very particular kind of body - one that seems to have very little relation to the biological body. Using psychopharmacology as an example, I suggest that the Gilles Deleuze's ethology offers one way through which both to engage seriously with the 'biological' body while at the same time resisting either an essentialist or biological determinist position. (shrink)

At a meeting shortly before his death, Malcolm X was asked by a young white listener: “What contribution can youth, especially students who are disgusted with racism, make to the black struggle for freedom?” Malcolm X's reply has become a familiar one: “Whites who are sincere should organize among themselves and figure out some strategy to break down prejudice that exists in white communities.… This has never been done.”.

For Tamsin Lorraine, the works of Luce Irigaray and Gilles Deleuze open up new ways of thinking about subjectivity. Focusing on the affinities between the theorists' views—while addressing weaknesses of each—she offers both a cogent analysis of their often challenging writings on this topic and an accessible introduction to their philosophical projects. Through her readings she articulates an approach to subjectivity as an embodied, dynamic process, one that speaks to beliefs about personal identity as well as to the practical problems (...) people face in their relations with one another.Lorraine begins by distinguishing between "conceptual" and "corporeal" considerations of subjectivity and by reviewing recent interdisciplinary efforts to theorize the body. She then turns to Irigaray and Deleuze, finding in the former's notion of the "feminine other" and in the latter's, unique conceptions of nomadic thinking inspiration for a model designed to overcome mind/body dualisms. Her analysis of Irigaray and Deleuze suggests a conception of humanity which amounts to a visceral philosophy—a way of thinking that is receptive to the fluxes of dynamic life forces. (shrink)

This paper addresses psychological factors that might interfere with informed consent on the part of stable patients as potential early-phase clinical trial participants. Thirty-six semistructured interviews with patients who had either diabetes or gout were conducted. We investigated stable patients’ attitudes towards participating in a fictitious first-in-human trial of a novel intervention. We focused on an in-depth analysis of those statements and explanations that indicated the existence of psychological factors impairing decision-making capacity. Three main themes emerged: insufficient comprehension of the (...) inherent logic of clinical trials, the recourse to trust over comprehension, and visceral factors that override deliberative process. Overall, our results indicate a limited psychological capacity on the part of stable patients to meet the requirements of informed consent as set by Declaration of Helsinki. A redesigned informed consent procedure should take account of these psychological realities. (shrink)

Feminist philosophers of technoscience have long argued that it is vital that we question biomedical and scientific claims to an immaterial and disembodied objectivity, and also, more specifically, that we disable the conception of medical visualising technologies as neutral or transparent conduits to the “fact” of the body. In this paper we suggest that corporeal feminism is well situated to provide such a critique. Feminist phenomenologists over the past decade have theorised embodiment in a number of critical ways, many deriving (...) concepts from the work of Merleau-Ponty, and emphasising the pliability and diversity of our body images and corporeal schematics. Others such as Elizabeth Wilson, Cathy Waldby and Drew Leder have considered the interdependence of our inner biology or viscerality with the socio-cultural inscriptions of embodiment. In this paper, these adaptations of phenomenology, and their account of the specificity and depth of embodied being, will be discussed and applied to the discourse of biomedicine and the apparatus of magnetic resonance imaging (MRI). Indo-Pacific Journal of Phenomenology , Volume 6, Edition 1 May 2006. (shrink)

The moral sentiments adumbrated by Adam Smith and Charles Darwin reflect some of our basic social appraisals of each other. One set of moral appraisals reflects disgust and withdrawal, a form of contempt. Another set of moral appraisals reflects active concern responses, an appreciation of the experiences (sympathy for some- one)of other individuals and approach related behaviors. While no one set of neural structures is designed for only moral appraisals, a diverse set of neural regions that include the gustatory/visceral (...) neural axis, basal ganglia and iverse neocortical sites underlie moral judgment. (shrink)

Vampire stories and folklores have originated from a range of sources; however, it is rather certain that the repulsive but attractive vampiric monster images in present popular culture are primarily derived from Anne Rice’s novel Interview with the Vampire. That being said, it was around the end of the eighteenth century that vampires first invaded the popular literary world, with literary vampires growing noticeably more powerful and perpetual than any of their monstrous predecessors in the years since the publication of (...) John Polidori’s successful short story The Vampyre in 1819. Due to associated aesthetic transformations, vampirism itself has become increasingly popular, to the extent that it now commands some followers who even worship vampiric rituals and lifestyles in spite of there being no solid, physical evidence of actual vampires, but rather only literary and imaginary examples of the creatures. In order to grasp how this fascination with vampires has turned into a quasi-religious phenomenon and ideology, a proper investigation of vampiric mechanisms and aesthetics should be empirical in nature. Utilizing Interview with the Vampire as an example due to its clearly substantial influence on current vampire imagery, this article examines how the paradoxical interchange between aversion and attraction plays its role in the visceral religion of the vampire-immersed world. (shrink)

The essay looks into the pedagogical role of philosophy in shaping the practice of dissent. Drawing on Gilles Deleuze and Felix Guattari’s radical understandings of philosophy as a machinic assemblage, it redeploys philosophy as a pedagogical tool which gathers traction from social events and remains invested in a dissensual politics. As a machinic assemblage committed to a dissensual politics philosophy works alongside collective modalities of enunciation that operate outside conventional structures of the academia. Such assemblages of enunciation often inhabit a (...) zone of critical inarticulacy brimming with the promise of new kinds of knowledge. How does philosophy critically interact with spaces of dissent along lines of gender, caste, ethnicity and nationalism to enable novel critical interventions? Deleuze and Guattari’s answer redirects us to a pragmatic engagement with philosophy which involves the manufacture of new pedagogical concepts as part of a schizoanalytic apparatus of protest. These concepts often emerge out of a visceral response to events unfolding around us. Needless to emphasize that such a philosophy which emerges out of a praxial encounter with life cannot be framed as an institutional staple, but takes shape as part of a visceral politics of the now. What then is the role of pedagogy in shaping an ethics of dissent and how can such a pedagogy mobilize plebeian acts of resistance in the sphere of the everyday? (shrink)

In my article "Controlling the noise," I present a phenomenological investigation of bodily experience in anorexia nervosa. Turning to descriptions of those who have suffered from AN, which repeatedly detail the experience of finding their bodies threatening, out of control and noisy, I suggest that the phenomenological conceptions of body-as-object, body-as-subject and visceral body can help us unpack the complex bodily experience of AN throughout its various stages. My claim is that self-starvation is enacted by a bodily-subject who wishes (...) to quell or reassert authority over a visceral body whose demands and needs she finds threatening to her autonomy.The relationship between body-as-object and... (shrink)

In this insightful and well-argued article, Osler aims to provide a more fine-grained, phenomenological account of anorectic bodily experience. She notes that although anorexia nervosa often is understood in terms of a distorted body image, this approach does not exhaustively or accurately reflect many subjects' bodily experiences, and also unduly privileges a third-person perspective over first-person accounts. In addition, focusing primarily on body image gives rise to the impression that AN is a form of radical dieting gone wrong as a (...) result of misperceiving or misjudging one's body size or shape. Osler emphasizes that AN is not a static disorder, but rather involves numerous stages. To account for the... (shrink)

Childhood adversity is associated with altered or dysregulated stress reactivity; these altered patterns of physiological functioning persist into adulthood. Evidence from both preclinical animal models and human neuroimaging studies indicates that early life experience differentially influences stressor-evoked activity within central visceral neural circuits proximally involved in the control of stress responses, including the subgenual anterior cingulate cortex (sgACC), paraventricular nucleus of the hypothalamus (PVN), bed nucleus of the stria terminalis (BNST) and amygdala. However, the relationship between childhood adversity and (...) the resting-state connectivity of this central visceral network remains unclear. To this end, we examined relationships between childhood threat and childhood socioeconomic deprivation, the resting-state connectivity between our regions of interest (ROIs), and affective symptom severity and diagnoses. We recruited a transdiagnostic sample of young adult males and females (n= 100; mean age = 27.28,SD= 3.99; 59 females) with a full distribution of maltreatment history and symptom severity across multiple affective disorders. Resting-state data were acquired using a 7.2-min functional magnetic resonance imaging (fMRI) sequence; noted ROIs were applied as masks to determine ROI-to-ROI connectivity. Threat was determined by measures of childhood traumatic events and abuse. Socioeconomic deprivation (SED) was determined by a measure of childhood socioeconomic status (parental education level). Covarying for age, race and sex, greater childhood threat was significantly associated with lower BNST-PVN, amygdala-sgACC and PVN-sgACC connectivity. No significant relationships were found between SED and resting-state connectivity. BNST-PVN connectivity was associated with the number of lifetime affective diagnoses. Exposure to threat during early development may entrain altered patterns of resting-state connectivity between these stress-related ROIs in ways that contribute to dysregulated neural and physiological responses to stress and subsequent affective psychopathology. (shrink)

There are some conspicuous differences between the sensibilities of cutaneous and visceral tissues: (1) Direct trauma, which readily produces pain when applied to the skin, is mostly without effect in healthy visceral tissue. (2) Pain that arises from visceral tissues is initially often poorly localised and diffuse. (3) With time, visceral pains are often referred to more superficial structures. (4) The site of referred pain may also show hyperalgesia. (5) In disease states, the afflicted viscera may (...) also become hyperalgesic. In this target article, I consider to what extent differences in the physiology, anatomy, and chemistry of peripheral processing systems explain these different sensibilities. In almost every aspect, there are subtle differences in the properties of the processing mechanisms for cutaneous and visceral information. These may arise because of distinct developmental cues operating in the two domains. Many of the differences between visceral and cutaneous afferents are quantitative rather than qualitative. The quantitative differences, for example in the density of afferent innervation, can be large. The quantitative differences in the numbers of afferents alone may be a sufficient explanation for some aspects of the differential sensibility, for example, the poor localisation of sensation and the apparent insensitivity to focal yet tissue- damaging stimuli. In addition, the few clear qualitative differences apparent in the innervations of the two tissue types may be of special importance. That the encoding of visceral nociceptive events may occur by an intensity mechanism rather than a specificity mechanism could be the key difference in viscerosensory and somatosensory processing. (shrink)

In this paper I question the primacy of argumentation relying solely on logic by showing how the body and mind are deeply connected and as a result how communication and argumentation are a product of this mind/body connection. In particular, I explore the physicality of argumentation through the research and writings on gestures and the embodied mind. Michael Gilbert’s theory of multi-modal argumentation provides the general approach for this elaboration.

In this paper I question the primacy of argumentation relying solely on logic by showing how the body and mind are deeply connected and as a result how communication and argumentation are a product of this mind/body connection. In particular, I explore the physicality of argumentation through the research and writings on gestures and the embodied mind. Michael Gilbert’s theory of multi-modal argumentation provides the general approach for this elaboration.

In this paper I question the primacy of argumentation relying solely on logic by showing how the body and mind are deeply connected and as a result how communication and argumentation are a product of this mind/body connection. In particular, I explore the physicality of argumentation through the research and writings on gestures and the embodied mind. Michael Gilbert’s theory of multi-modal argumentation provides the general approach for this elaboration.

Nationalism can be closely associated with powerful feelings about the relationship among cultural heritage, identity and embodied experience. Almost by definition this relationship is expressed in terms of continuity, distinctiveness and the purity of tradition, to an extent that nationalistic sentiments can be said to be ‘visceral.’ Contrasting the way in which the body is implicated in nature cure and Ayurveda, two forms of medicine closely linked to nationalism in India, this article presents an analytical perspective on the embodiment (...) of viscerality to provide a more nuanced understanding of how these experiences blur distinctions of cultural continuity and how an ecology of the body shapes the cultural politics of tradition in India. (shrink)

The World Health Organization, in its last review of its International Classification of Diseases, established a new classification for chronic pain. Among the principal categories, of particular interest is chronic primary pain as a new type of diagnosis in those cases in which the etiology of the disease is not clear, being termed as chronic primary visceral pain when it is situated in the thorax, abdomen, or pelvis. Due to the novelty of the term, the objective of the systematic (...) review was to examine the psychopathological and neuropsychological disorders associated with chronic primary visceral pain. We carried out a search of the scientific literature following the PRISMA directives using the Pubmed, Medline, PsycInfo and Scopus databases. A total of 33 articles were selected after applying the inclusion and exclusion criteria. The analysis of the studies showed that most persons with chronic primary visceral pain suffer from at least one psychological disorder; the most prevalent being anxiety, depressive or somatoform disorders. The most frequent psychopathological symptoms are anxiety, depression and somatization. Similarly, the findings are insufficient to determine the existence of deficits in the domains of executive functioning, memory and intelligence. However, the existence of attention biases does seem to be clear. This review supposes a starting point for conceptualizing chronic primary visceral pain. It is necessary to continue further research so as to obtain a better understanding of this pathology and the disorders associated. (shrink)

This edited volume traces cultural appearances of disgust and investigates the varied forms and functions disgust takes and is given in both established and vernacular cultural practises. Contributors focus on the socio-cultural creation, consumption, reception and experiencing of disgust, a visceral emotion whose cultural situatedness and circulation has historically been overlooked in academic scholarship. Chapters challenge and supplement the biological understanding of disgust as a danger reaction and as a base emotion evoked by the lower senses, touch, taste and (...) smell, through a wealth of original case studies in which disgust is analyzed in its aesthetic qualities, and in its cultural and artistic appearances and uses, featuring visual and aural media. Because it is interdisciplinary, the book will be of interest to scholars in a wide range of fields, including visual studies, philosophy, aesthetics, sociology, history, literature, and musicology. (shrink)

Given the prevalence of social media, a nascent but important area of research is the effect of social media posting on one’s own self. It is possible that an individual’s social media posts may have predictive capacity, especially in relation to health behavior. Researchers have long used concepts from the theory of reasoned action to predict health behaviors. The theory does not account for social media, which may influence or predict health behaviors. The purpose of this study was to test (...) a model including Facebook alcohol displays and constructs from the theory of reasoned action to predict binge drinking. Incoming college freshmen from two schools (312 participants between 18 and 19 years old) were interviewed prior to (T1) and 1 year into college (T2), and their Facebook profiles were evaluated for displayed alcohol content. Path modeling was used to evaluate direct and indirect paths predicting binge drinking. Path analysis suggested that Facebook alcohol displays at T1 directly predict binge drinking at T2, while alcohol attitude both directly and indirectly predicts binge drinking. Based on these results, a preliminary model of social media presentation and action is discussed. (shrink)

Research has shown repeatedly that attention influences implicit learning effects. In a similar vein, interoceptive awareness might be involved in unaware fear conditioning: The fact that the CS is repeatedly presented in the context of aversive bodily experiences might facilitate the development of conditioned responding. We investigated the role of interoceptive attention in a subliminal conditioning paradigm. Conditioning was embedded in a spatial cueing task with subliminally presented cues that were followed by a masking stimulus. Response times to the targets (...) that were either validly or invalidly predicted by the cues served as index of conditioning. Interoceptive attention was manipulated between-subjects. Half the participants completed a heartbeat detection task before conditioning. This task tunes attention to one’s own bodily signals. We found that conditioned responding was facilitated in this latter group of participants. These results are in line with the hypothesis that a rise interoceptive attention enhances unaware conditioned responding. (shrink)

Regulators of G protein signaling (RGS) proteins provide timely termination of G protein‐coupled receptor (GPCR) responses. Serving as a central control point in GPCR signaling cascades, RGS proteins are promising targets for drug development. In this review, we discuss the involvement of RGS proteins in the pathophysiology of the gastrointestinal inflammation and their potential to become a target for anti‐inflammatory drugs. Specifically, we evaluate the emerging evidence for modulation of selected receptor families: opioid, cannabinoid and serotonin by RGS proteins. We (...) discuss how the regulation of RGS protein level and activity may modulate immunological pathways involved in the development of intestinal inflammation. Finally, we propose that RGS proteins may serve as a prognostic factor for survival rate in colorectal cancer. The ideas introduced in this review set a novel conceptual framework for the utilization of RGS proteins in the treatment of gastrointestinal inflammation, a growing major concern worldwide. (shrink)

Pornographic Sensibilities stages a conversation between two fields-Medieval/Early Modern Hispanic Studies and Porn Studies-that traditionally have had little to say to each other. The collection offers innovative new approaches to the study of gendered and sexualized bodies in medieval and early modern textual production, including literary and historical documents. The volume's embrace of the interpretative tools of Porn Studies also inscribes a critical provocation: in what ways can contemporary modes of reading the past serve to freshly illuminate not only the (...) contours of that same past but also the very critical assumptions of the present upon which fields like medieval and early modern Hispanic Studies are built? In this way, Pornographic Sensibilities encourages at once both rigorous historicizations of pre- and early-modern culture, and playful engagement with "presentism," considered here as a critical tool to undress the hidden assumptions of both past and present. This move substantively challenges long-held critical orthodoxies among scholars of pre-Enlightenment periods, for whom the very category of "pornography" itself has often problematically been framed as an anachronism when applied to their work. (shrink)