An emerging concept is that quiescent mature skeletal cells provide an important cellular source for bone regeneration. It has long been considered that a small number of resident skeletal stem cells are solely responsible for the remarkable regenerative capacity of adult bones. However, recent in vivo lineage‐tracing studies suggest that all stages of skeletal lineage cells, including dormant pre‐adipocyte‐like stromal cells in the marrow, osteoblast precursor cells on the bone surface and other stem and progenitor cells, are (...) concomitantly recruited to the injury site and collectively participate in regeneration of the damaged skeletal structure. Lineage plasticity appears to play an important role in this process, by which mature skeletal cells can transform their identities into skeletal stem cell‐like cells in response to injury. These highly malleable, long‐living mature skeletal cells, readily available throughout postnatal life, might represent an ideal cellular resource that can be exploited for regenerative medicine. (shrink)

Platelets have important hemostatic functions in repairing blood vessels upon tissue injury. Cytokines, growth factors, and metabolites stored in platelet α‐granules and dense granules are released upon platelet activation and clotting. Emerging evidence indicates that such platelet‐derived signaling factors are instrumental in guiding tissue regeneration. Here, we discuss the important roles of platelet‐secreted signaling factors in skeletal muscle regeneration. Chemokines secreted by platelets in the early phase after injury are needed to recruit neutrophils to injured muscles, and impeding this (...) early step of muscle regeneration exacerbates inflammation at later stages, compromises neo‐angiogenesis and the growth of newly formed myofibers, and reduces post‐injury muscle force production. Platelets also contribute to the recruitment of pro‐regenerative stromal cells from the adipose tissue, and the platelet releasate may also regulate the metabolism and proliferation of muscle satellite cells, which sustain myogenesis. Therefore, harnessing the signaling functions of platelets and the platelet secretome may provide new avenues for promoting skeletal muscle regeneration in health and disease. (shrink)

Despite decades of research, remaining safety concerns regarding disease transmission, heterotopic tissue formation, and tumorigenicity have kept stem cell‐based therapies largely outside the standard‐of‐care for musculoskeletal medicine. Recent insights into trophic and immune regulatory activities of mesenchymal stem cells (MSCs), although incomplete, have stimulated a plethora of new clinical trials for indications far beyond simply supplying progenitors to replenish or re‐build lost/damaged tissues. Cell banks are being established and cell‐based products are in active clinical trials. Moreover, significant advances have also (...) been made in the field of pluripotent stem cells, in particular the recent development of induced pluripotent stem cells. Their indefinite proliferation potential promises to overcome the limited supply of tissue‐specific cells and adult stem cells. However, substantial hurdles related to their safety must be overcome for these cells to be clinically applicable. (shrink)

Mars 1980. Une série d'entretiens publiés par le Nouvel Observateur fait scandale. Jean-Paul Sartre, un mois avant sa mort, y révoque des pans entiers de son oeuvre, dénigrant la notion d'angoisse et reléguant l'athéisme pour s'intéresser au messianisme juif et à la résurrection des corps. Face à lui, son dernier secrétaire, Benny Lévy. Accusé par Simone de Beauvoir de manipuler Sartre, Benny Lévy offre à l'écrivain une dernière occasion de revisiter son oeuvre.

Skeletal muscle stem cells or satellite cells are responsible for muscle regeneration in the adult. Although satellite cells are highly resistant to stress, and display greater capacity to repair molecular damage than the committed progeny, their regenerative potential declines with age. During ageing, satellite cells switch to a state of permanent cell cycle arrest or senescence which prevents their activation. A recent study reveals that the senescence of satellite cell relies on defective autophagy, the quality control mechanism that (...) degrades damaged proteins and organelles. Molecular damage is generated by oxidative stress that also promotes epigenetic changes that activate the expression of master genes, in a double‐hit mechanism that ensures senescence. Importantly, genetic, and pharmacological correction of defective autophagy reverses satellite cell senescence and restores muscle regeneration in geriatric mice, with perspectives of modulating age‐related functional decline of muscle. This study provides new clues to understand stem cell and organismal ageing. (shrink)

In recent years, live imaging has been adopted to study stem cells in their native environment at cellular resolution. In the skeletal muscle field, this has led to visualising the initial events of muscle repair in mouse, and the entire regenerative response in zebrafish. Here, we review recent discoveries in this field obtained from live imaging studies. Tracking of tissue resident stem cells, the satellite cells, following injury has captured the morphogenetic dynamics of stem/progenitor cells as they facilitate (...) repair. Asymmetric satellite cell division generated a clonogenic progenitor pool, providing in vivo validation for this mechanism. Furthermore, there is an emerging role of stem/progenitor cell guidance at the injury site by cellular protrusions. This review concludes that live imaging is a critical tool for discovering the distinct processes that occur during regeneration, emphasising the importance of imaging in diverse animal models to capture the entire scope of stem cell functions. (shrink)

Background The ideal basis of age estimation is considered to be a combination of clinical, skeletal and dental examinations. It is not easy to determine how forensic physicians take account of evidence-based data obtained from medical journals in their medical decision-making. The question of what is an ethically acceptable probability that adolescents are incorrectly considered to be over 18 has not been answered. Methods In a retrospective study over 1 year (2007), 498 files (for 141 female subjects and 357 (...) male subjects) regarding age assessment requested by the public prosecutor's office for purposes of criminal or asylum proceedings were reviewed. Chronological age was estimated from a combination of physical examination, radiographic examination of the left hand and determination of dental status. Results Estimates of chronological age in 498 subjects claiming to be 9–14 years old were incompatible with the alleged age in 356 (71%) when made by the forensic physician but in only 17 (3%) when based on data from published studies on age estimation in adolescents. Conclusions The present study suggests that in most cases the forensic physician ignores the adolescent's word. Medical mission and ethics imply a need to listen to the claims of persons in custody, whatever the risk of false claims. This situation should prompt forensic physicians to keep up with published data on estimating the age of adolescents. (shrink)

Moral Repair examines the ethics and moral psychology of responses to wrongdoing. Explaining the emotional bonds and normative expectations that keep human beings responsive to moral standards and responsible to each other, Margaret Urban Walker uses realistic examples of both personal betrayal and political violence to analyze how moral bonds are damaged by serious wrongs and what must be done to repair the damage. Focusing on victims of wrong, their right to validation, and their sense of justice, Walker (...) presents a unified and detailed philosophical account of hope, trust, resentment, forgiveness, and making amends - the emotions and practices that sustain moral relations. Moral Repair joins a multidisciplinary literature concerned with transitional and restorative justice, reparations, and restoring individual dignity and mutual trust in the wake of serious wrongs. (shrink)

Albert and De Ruiter provide an introduction to the Conversation Analytic approach to ‘repair’: the ways in which people detect and deal with troubles in speaking, hearing and understanding in conversation. They explain the basic turn‐taking structures involved, provide examples, explain recent developments in the field and highlight some important points of contact and contrast with work in the Cognitive Sciences.

In an age of apparent disrepair as the climate crisis takes hold and neoliberalism fails to liberate, as the cost of living rises and rights are retracted, the need for a reparative turn is overdue. But what is repair? If repair is contained in moments of total breakdown, then the reparative acts of care that sustain the world are denied. Countering these forces and the urgency prescribed by the crisis of disrepair and in what too often appears as (...) the proprietary epistemology of repair, in this paper I offer an account of ‘repairability’. Structured in relation to the reparative gaze of feminist theory and poetic thinking, repairability assumes a material trace, I contend, through the vernacular archive of Cuban artist-ethnographer Ernesto Oroza. Oroza’s work offers a compelling case study through which to think the possibility of repair as an act of worldly becoming. (shrink)

This article explores the forms of moral repair that the wrongdoer has to perform in an attempt to make amends for her past wrongdoing, with a focus on the issues of interpersonal moral repair; that is, what a wrongdoer can do to merit her victim‘s forgiveness and achieve reconciliation with her community. The article argues against the very general demands of atonement that amount to an obligation to stop being someone who commits wrongs—to become a moral saint—and suggests (...) a new form of atonement that is more practical and useful in our everyday life. (shrink)

Healey et al. use experiments with chat dialogues to test the hypothesis that language co‐ordination is driven by ‘running repairs’. They replace signals of understanding such as “okay” with weaker, ‘spoof’ signals like “ummm”, and replace specific requests for clarification like “on the left?” with signals that suggest a higher degree of misunderstanding like “what?”. The latter manipulation causes participants to switch rapidly to more abstract forms of referring expression.

Moral repair is an important way for firms to heal moral relationships with stakeholders following a transgression. The concept is rooted in recognition theory, which is often used to develop normative perspectives and prescriptions, but the same theory has also propelled a view of moral repair as premised on negotiation between offender and victim(s), which involves the complex social construction of the transgression and the appropriate amends. The tension between normative principles and socioconstructivist implementation begs the question how (...) offending firms should approach moral repair. Addressing this question, we develop a two-level conceptualization of moral repair, distinguishing between procedural and substantive levels of practice, which accommodate normativity and socioconstructivism, respectively. In so doing, we enrich the literature by 1) promoting conceptual clarity, 2) refining understanding of the moral repair process, and 3) suggesting the use of a unified, configurational approach to studying (nonlinear) relations between amends and moral outcomes. (shrink)

In humans, there are two skeletal muscle α‐actinins, encoded by ACTN2 and ACTN3, and the ACTN3 genotype is associated with human athletic performance. Remarkably, approximately 1 billion people worldwide are deficient in α‐actinin‐3 due to the common ACTN3 R577X polymorphism. The α‐actinins are an ancient family of actin‐binding proteins with structural, signalling and metabolic functions. The skeletal muscle α‐actinins diverged ∼250–300 million years ago, and ACTN3 has since developed restricted expression in fast muscle fibres. Despite ACTN2 and ACTN3 (...) retaining considerable sequence similarity, it is likely that following duplication there was a divergence in function explaining why α‐actinin‐2 cannot completely compensate for the absence of α‐actinin‐3. This paper focuses on the role of skeletal muscle α‐actinins, and how possible changes in functions between these duplicates fit in the context of gene duplication paradigms. (shrink)

Some people in global health are systematically subjected to epistemic wrongs, harms and injustices. And sometimes, with these epistemic wrongs, come more fundamental harms to their sense of self or dignity. -/- Each person has a moral right not to be treated as inferior. This moral right has found different forms of protection under dignity-based mechanisms. But these mechanisms do not extend, at least not explicitly, to epistemic wrongs, harms and injustices. -/- This article tries to pave the way for (...) a dignity-based approach to epistemic repair in global health, specifically through the lens of human rights. (shrink)

The topic of moral repair in the aftermath of breaches of trust and harmdoing has grown in importance within the past few years. In this paper, we present the results of a qualitative study that offers insight into a series of key issues related to offender efforts to repair interpersonal harm in the workplace: What factors motivate offenders to make amends with those they have harmed? In what ways do offenders attempt to make amends? What outcomes emerge from (...) attempts to make amends? Drawing from the findings, we build an inductive model intended to guide future business ethics and management inquiry and research in this area. (shrink)

Ontologies represent principled, formalised descriptions of agents’ conceptualisations of a domain. For a community of agents, these descriptions may differ among agents. We propose an aggregative view of the integration of ontologies based on Judgement Aggregation (JA). Agents may vote on statements of the ontologies, and we aim at constructing a collective, integrated ontology, that reflects the individual conceptualisations as much as possible. As several results in JA show, many attractive and widely used aggregation procedures are prone to return inconsistent (...) collective ontologies. We propose to solve the possible inconsistencies in the collective ontology by applying suitable weakenings of axioms that cause inconsistencies. (shrink)

This paper advances a fresh theorization of historicity. The word and concept of historicity has become so widespread and popular that they have ceased to have definite meaning and are used to stand for unsupported notions of the values inherent in human experience. This paper attempts to repair the concept by re-defining it as the temporal aspect of the interdependence of life; having history is to have a life intertwined with the lives of all others and with the universe. (...) After separating out the looser uses, surveying some of the literature, and defining what needs to be done, the paper examines shortcomings in the very different and widely influential conceptions of historicity of Koselleck and Heidegger. It then advances a new conception and fits it into the theoretical and moral capabilities of the philosophy of history as a core of philosophical anthropology. (shrink)

The repair of chromosomal double‐strand breaks (DSBs) by homologous recombination is essential to maintain genome integrity. The key step in DSB repair is the RecA/Rad51‐mediated process to match sequences at the broken end to homologous donor sequences that can be used as a template to repair the lesion. Here, in reviewing research about DSB repair, I consider the many factors that appear to play important roles in the successful search for homology by several homologous recombination mechanisms.

Quantified hybrid logic is quantified modal logic extended with apparatus for naming states and asserting that a formula is true at a named state. While interpolation and Beth's definability theorem fail in a number of well-known quantified modal logics , their counterparts in quantified hybrid logic have these properties. These are special cases of the main result of the paper: the quantified hybrid logic of any class of frames definable in the bounded fragment of first-order logic has the interpolation property, (...) irrespective of whether varying, constant, expanding, or contracting domains are assumed. (shrink)

(1996). Repairing the moral deficits of capitalism: The role of the nonprofit sector. The European Legacy: Vol. 1, Fourth International Conference of the International Society for the study of European Ideas, pp. 595-600.

"Repairing the Tower of Babel" addresses three major themes. The thesis begins with the question of how James Fergusson felt he could describe both Samuel Taylor Coleridge and Auguste Comte as influential in the development of his own theory of beauty in art. Following from this initial question, the thesis examines in detail the attempts at the reconciliation of Romanticism and Positivism at the beginning of the nineteenth century, especially in the works of William Whewell, Auguste Comte, and Samuel Taylor (...) Coleridge. In light of these attempts, the work looks at the influence of the developing sciences of geology, chemistry, and biology and the various methodologies associated with these organic sciences that were to overturn the Newtonian methods of science which had been followed throughout the eighteenth century. Finally, the thesis provides an overview of the development of aesthetic theory from John Locke to Immanual Kant in an attempt to outline the development of the fundamental dichotomies in aesthetics and theory of mind that the nineteenth century felt it must resolve. (shrink)

Frege’s writings contain arguments for the thesis (i) that a thought expressed by a sentence S is a structured object whose composition pictures the composition of S, and for the thesis (ii) that a thought is an unstructured object. I will argue that Frege’s reasons for both (i) and (ii) are strong. Frege’s explanation of the difference in sense between logically equivalent sentences rests on assumption (i), while Frege’s claim that the same thought can be decomposed differently makes (ii) plausible. (...) Thoughts are supposed to do work that requires that they be structured and work that requires that they be unstructured. But this cannot be! While the standard response to this problem is to reject either (i) or (ii), I propose a charitable repair in the spirit of Frege’s theory that accepts both. The key idea can be found in Frege’s Basic Laws of Arithmetic(BL, GGA). Frege argues that the thought expressed by a sentence is determined by the truth-conditions that can be derived from the semantic axioms for the sentence constituents. The fact that the same axiomatic truth-condition can be derived in different ways from different semantic axioms suggests a Fregean solution of the dilemma: A thought is a type that is instantiated by all sequences of senses (decomposed thoughts) that have the same axiomatic truth-conditions. This allows for multiple decomposability of the same thought (for different decomposed thoughts can have the same axiomatic truth-conditions) and for a notion of containment (the decomposed thought contains those senses whose semantic axioms are needed in the derivation of the truth-conditions). My proposal combines the virtues of (i) and (ii) without inheriting their vices. (shrink)

DNA damage repair within telomeres are suppressed to maintain the integrity of linear chromosomes, but the accidental activation of repairs can lead to genome instability. This review develops the concept that mechanisms to repair DNA damage in telomeres contribute to genetic variability and karyotype evolution, rather than catastrophe. Spontaneous breaks in telomeres can be repaired by telomerase, but in some cases DNA repair pathways are activated, and can cause chromosomal rearrangements or fusions. The resultant changes can also (...) affect subtelomeric regions that are adjacent to telomeres. Subtelomeres are actively involved in such chromosomal changes, and are therefore the most variable regions in the genome. The case of Caenorhabditis elegans in the context of changes of subtelomeric structures revealed by long‐read sequencing is also discussed. Theoretical and methodological issues covered in this review will help to explore the mechanism of chromosome evolution by reconstruction of chromosomal ends in nature. (shrink)

When interlocutors repeatedly describe referents to each other, they rapidly converge on referring expressions which become increasingly systematized and abstract as the interaction progresses. Previous experimental research suggests that interactive repair mechanisms in dialogue underpin convergence. However, this research has so far only focused on the role of other-initiated repair and has not examined whether self-initiated repair might also play a role. To investigate this question, we report the results from a computer-mediated maze task experiment. In this (...) task, participants communicate with each other via an experimental chat tool, which selectively transforms participants’ private turn-revisions into public self-repairs that are made visible to the other participant. For example, if a participant, A, types “On the top square,” and then before sending, A revises the turn to “On the top row,” the server automatically detects the revision and transforms the private turn-revisions into a public self-repair, for example, “On the top square umm I meant row.” Participants who received these transformed turns used more abstract and systematized referring expressions, but performed worse at the task. We argue that this is due to the artificial self-repairs causing participants to put more effort into diagnosing and resolving the referential coordination problems they face in the task, yielding better grounded spatial semantics and consequently increased use of abstract referring expressions. (shrink)

This paper describes a generative theory of bugs. It claims that all bugs of a procedural skill can be derived by a highly constrained form of problem solving acting on incomplete procedures. These procedures are characterized by formal deletion operations that model incomplete learning and forgetting. The problem solver and the deletion operator have been constrained to make it impossible to derive “star‐bugs”—algorithms that are so absurd that expert diagnosticians agree that the alogorithm will never be observed as a bug. (...) Hence, the theory not only generates the observed bugs, it fails to generate star‐bugs.The theory has been tested on an extensive data base of bugs for multidigit subtraction that was collected with the aid of the diagnostic systems buggy and debuggy. In addition to predicting bug occurrence, by adoption of additional hypotheses, the theory also makes predictions about the frequency and stability of bugs, as well as the occurrence of certain latencies in processing time during testing. Arguments are given that the theory can be applied to domains other than subtraction and that it can be extended to provide a theory of procedural learning that accounts for bug acquisition. Lastly, particular care has been taken to make the theory principled so that it can not be tailored to fit any possible data. (shrink)

This article addresses the claim that some contemporary states may possess obligations to pay reparations as a result of the lasting effects of a particular form of historic imperialism: colonialism. Claims about the harms and benefits caused by colonialism must make some kind of comparison between the world as it currently is, and a counterfactual state where the injustice which characterised so much of historic interaction between colonisers and the colonised did not occur. Rather than imagining a world a world (...) where there was no such interaction, this article maintains that the appropriate counterfactual is one where relations between different communities were characterized by an absence of domination and exploitation. This means that current day states may possess reparative duties which are much more extensive than is often supposed. (shrink)

Amphibians that undergo a metamorphosis provide an unparalleled opportunity to investigate how skeletal shape is generated, preserved, and transformed in development. Their pharyngeal arch (PA) cartilages, which support breathing and feeding behaviors, form embryonically from cranial neural crest cells, grow isometrically at larval stages, and abruptly change shape during metamorphosis. Further, the shape changes occur in three different ways: some adult cartilages form de novo, others emerge from within resorbing larval cartilages and some larval cartilages reshape themselves at the (...) cellular level. Isometric growth followed by abrupt shape change is unique to amphibian PA cartilages, which suggests that the origin and evolution of amphibian metamorphosis has been influenced by the tissue properties of cartilage. This essay reviews the functional role of the PA skeleton in frogs and salamanders and presents a mechanistic framework for understanding how its shape is generated, preserved, and transformed at the levels of cell behavior and specification mechanisms. (shrink)

Cytoskeletal organization in embryonic skeletal muscle cells has been examined by transmission electron microscopy; the technique involves preparation using the platinum replication method of freezedried samples, with and without cryofracture. The cytoskeletons in developing muscle cells appear to play a role in preserving cell shape as well as in anchoring myofibrils to cell membrane.

This article describes methods used in estimating skeletal age based both on the evaluation of skeletal maturation of the palm and the wrist and the Cervical Vertebral Maturation method. The method of evaluating the skeletal age based on the measurement of cervical vertebrae with equations introduced by A. Machorowska-Pieniążek is also mentioned. The article shows results obtained by computer analysis of the age of cervical vertebrae compared to the results gained from the implemented equations provided by A. (...) Machorowska-Pieniążek and the results obtained from the atlas method. (shrink)

Our article explores the repair practices pilots use to correct various troubles during flights. The intersubjective understanding of action is a salient part of the time-critical activities of aviation. Repairs solve troubles before any accident risk emerges, thus contributing to flight safety. In repair practices, the social and technical environment is interwoven. If remedies concern faulty lines of action, they target the techno-material condition of the aircraft. Such repair practices are not repairs of talk, but remedies of (...) action in a socio-material interaction. We discuss remedies of action as a particular type of repair practice, and outline their role in socio-material interactions. The aim is to continue building a holistic analysis of social action, not just to add a multimodal layer over an analysis of talk. The rethinking of social action contributes to the exploration of social actions anchored to their socio-material environment. (shrink)

Despite widespread interest in the topic of moral repair in the business ethics literature and in the workplace, little is currently known about moral repair with regard to the self—i.e., how and why individuals repair themselves in the aftermath of harming others within workplace contexts and what factors may influence the success of self-repair. We conducted a qualitative study in the context of health care organizations to develop an inductive model of self-repair in the workplace. (...) Our findings reveal a set of factors, including reactions to the harm incident, motivating factors, and methods of self-repair that involve intrapersonal (e.g., self-compassion) and interpersonal (e.g., seeking feedback and support from co-workers and managers) actions. We discovered that self-repair, or what we characterize as “moral self-repair” is a complex process characterized by important ethical, emotional, and social dimensions and that the effectiveness of self-repair actions is moderated by the actions of those within the organization (e.g., co-workers, managers) and outside the organization (e.g., families, friends, counselors). These social actors can promote self-repair by offering encouragement and support, or undermine self-repair by communicating a lack of trust and respect that reinforces self-blame. This model of self-repair is intended to guide future ethics research on the topic of moral self-repair and offers insight to practicing managers. (shrink)

Peer interaction constitutes a focal site for understanding learning orientations and autonomous learning behaviors. Based on 10 h of video-recorded data collected from small-size conversation-for-learning classes, this study, through the lens of Conversation Analysis, analyzes instances in which L2 learners spontaneously exploit learning opportunities from the on-task public talk and make them relevant for private learning in sequential private peer interaction. The analysis of extended negation-for-meaning practices in peer interaction displays how L2 learners orient to public repair for their (...) learning opportunities in an immediate manner and in so doing, how different participation framework is being utilized to maximize their learning outcomes. As these extended repair practices are entirely managed by learners themselves, they yield both efficient and inefficient learning outcomes. Findings reveal that learners frequently resort to their peers to recycle the focal trouble words for learning opportunities, shifting their participating role from the on looking audience to active learners. By reporting the rather under-researched post-repair negotiation-for-meaning sequence in peer interactions, the study highlights the relevance between on-task classroom activities and private learning, contributing to understanding private learning behaviors in the language classroom and learning as a co-constructed activity locally situated in peer interaction. (shrink)

'Ruin, Repair, and Responsibility' explores and Arendtean conceptualization of the three and their interrelations. At issue is how to understand (a) ruin in its socio-historical specificity but also in terms of what it is that breaks down in the weave of human relations, (b) the possibility or impossibility of repair, and (c) what responsibility may mean when repair is impossible since the very conditions for its possibility have been destroyed.

Common‐sense intuition suggests that, when people are engaged in informational exchanges, they communicate so as to be reasonably sure that they perform the exchanges faithfully. Over the years, we have found evidence suggesting that this intuition, which is woven into several influential theories of human communication, may be misleading. We first summarize this evidence and discuss its potential limitations. Then, we present a new study that addresses the potential limitations. A confederate instructed participants to “pick up the skask” from a (...) tray containing six objects and move it to a specific location. Since skask is a non‐word invented by us, participants had to ask for clarification to perform the instruction faithfully. In contradiction with the intuition that people pursue faithfulness when engaged in informational exchanges, 29 of the 48 participants we tested performed the instruction without asking for clarification. We identified a possible cause for this behavior, which occurred more frequently when avoiding the clarification was unlikely to result in an overt consequence (an error in the execution of the instruction that could be noticed by the confederate or the experimenter). Other factors such as individual differences and the specific interpersonal dynamics of the experimental settings, if they played a role at all, did it to an extent that is unlikely to be comparable to that of the role played by overt consequences. Considered together, our various assessments of the extent to which people engage in faithful informational exchanges converge on a simple conclusion: Communicating faithfully is a substantially demanding task, and people often fail at it. We discuss the implications of this conclusion and speculate on its relevance for understanding the evolutionary past of human communication. (shrink)

Moral injury results from the violation of deeply held moral commitments leading to emotional and existential distress. The phenomenon was initially described by psychologists and psychiatrists associated with the US Departments of Defense and Veterans Affairs but has since been applied more broadly. Although its application to healthcare preceded COVID-19, healthcare professionals have taken greater interest in moral injury since the pandemic’s advent. They have much to learn from combat veterans, who have substantial experience in identifying and addressing moral injury—particularly (...) its social dimensions. Veterans recognise that complex social factors lead to moral injury, and therefore a community approach is necessary for healing. We argue that similar attention must be given in healthcare, where a team-oriented and multidimensional approach is essential both for ameliorating the suffering faced by health professionals and for addressing the underlying causes that give rise to moral injury. (shrink)

Seunghyun Song’s recent article on epistemic repair for Japan’s military sex slavery lays out the case for considering acknowledgment as a form of reparative justice particularly suited to redressing epistemic wrongs. I agree with Song, but press her on the relationship between epistemic repair and reparative justice more generally. I also outline other forms that backward-looking epistemic responsibility might take. Distinguishing between revisionism and denialism, I ask: Should individual agents who’ve publicly made denialist statements about Japan’s military sex (...) slavery be criminally liable? Should their revisionist counterparts be subject to the kind of social sanctions that are associated with present-day cancel culture? (shrink)

Abstract:Open neural tube defects or myelomeningoceles are a common congenital condition caused by failure of closure of the neural tube early in gestation, leading to a number of neurologic sequelae including paralysis, hindbrain herniation, hydrocephalus and neurogenic bowel and bladder dysfunction. Traditionally, the condition was treated by closure of the defect postnatally but a recently completed randomized controlled trial of prenatal versus postnatal closure demonstrated improved neurologic outcomes in the prenatal closure group. Fetal surgery, or more precisely maternal-fetal surgery, raises (...) a number of ethical issues that we address including who the patient is, informed consent, surgical innovation and equipoise as well maternal assumption of risk. As the procedure becomes more widely adopted into practice, we suggest close monitoring of new fetal surgery centers, in order to ensure that the positive results of the trial are maintained without increased risk to both the mother and fetus. (shrink)

Departing from the thought-provoking conversation between David Theo Goldberg and Achille Mbembe on the driving themes in Mbembe’s Critique of Black Reason, this commentary elaborates upon three topics that emerge in this conversation: the role of desire and how it is articulated in black abjection, the politics of care, and contemporary practices of repairing the injustices perpetrated in the context of European modernity. It is emphasized that black reason as a practice of repairing and transformation is especially enacted within contemporary (...) movements like the refugee movements organized around the Black Mediterranean and in the lived freedom archives and abolitionist imaginaries of movements where gender and race cross-cut. Characterized by their transnational dimension and a radical openness towards new beginnings, these expressions of black reason imagine and reinvent justice and democracy anew. (shrink)

Sex steroids, through their receptors, have potent effects on the signal pathways involved in osteogenic or myogenic differentiation. However, a considerable segment of those signal pathways has a prominent role in epithelial neoplastic transformation. The capability to intervene locally has focused on specific ligands for the receptors. Nevertheless, many signals are mapped to interactions of steroid receptor motifs with heterologous regulatory proteins. Some of those proteins interact with the glucocorticoid receptor and other factors essential to cell fate. Interactions of steroid (...) receptor domain motifs with heterologous proteins affect specific target pathways; consequently, manipulation of specified protein modules complexed with steroid receptors may be a next major step for enhancing molecular targeted therapeutics. In the future, intervention at specific sections of receptor primary sequence may prove therapeutically more efficient in targeting pathways of choice than ligand selectivity can be. (shrink)

The calpactins are a novel group of proteins associated with the membrane skeleton. The two main forms, calpactin I and II, have been shown to bind to the cytoskeletal proteins actin and spectrin, as well as to anionic phospholipids, which may imply some sort of bridging role. By raising monoclonal antibodies to the heavy and light chains of calpactin I, and to calpactin II, the protein subunits were shown to be coordinately expressed, and the existence of separate calpactin pools hypothesized. (...) Calcium‐binding studies suggest that the calpactins may translate Ca2+ signals into cellular responses at the membrane. Structural studies have revealed two distinct domains and are beginning to throw light on heavy‐‐light chain interaction and cytoskeletal attachment. (shrink)

Ontology engineering is a hard and error-prone task, in which small changes may lead to errors, or even produce an inconsistent ontology. As ontologies grow in size, the need for automated methods for repairing inconsistencies while preserving as much of the original knowledge as possible increases. Most previous approaches to this task are based on removing a few axioms from the ontology to regain consistency. We propose a new method based on weakening these axioms to make them less restrictive, employing (...) the use of refinement operators. We introduce the theoretical framework for weakening DL ontologies, propose algorithms to repair ontologies based on the framework, and provide an analysis of the computational complexity. Through an empirical analysis made over real-life ontologies, we show that our approach preserves significantly more of the original knowledge of the ontology than removing axioms. (shrink)

This study examines the conditions under which apologies help to elicit forgiveness and restore trust following trust violations between leaders and followers. The intentionality and severity of violations are examined in a critical incident study and a laboratory study. The results support a model in which forgiveness mediates the relation of apology quality and trust. More importantly, the moderation–mediation model shows that apology quality influenced forgiveness and subsequent trust following violations that were moderate in severity–intentionality combination. The effect of apologizing (...) affects trust directly without forgiveness when the severity–intentionality combination held minor or extreme intensity. The results suggest a range in which apologies are effective and enrich understanding of the conditions under which trust can be recovered through an apology–forgiveness process in leader–follower relationships. The contribution of the study lies in elucidating that the combination of severity and intentionality of leaders’ trust violations has greater importance than either one separately. (shrink)

This study examines the construction of a positive corporate image in public statements issued by 12 Chilean companies facing a crisis in the period January 2008 to July 2010. Drawing on repair image theory, narrative theory, and argumentation theory, this article aims to investigate which discursive strategies and which linguistic structures have been instrumental in this construction. Three analytical categories were investigated in this study, namely, image repair strategies, construction of ethos, and narratives. In each of these categories, (...) special attention is paid to lexico-grammatical features and socio-pragmatic strategies. The analysis shows that the core image repair strategy is denial, which is accomplished through a highly rhetorical language. It also demonstrates how the public statements create a secondary narrative of the companies’ good sense, good moral character, and goodwill, through the use and abuse of linguistic and pragmatic devices. (shrink)

Critics often note that our choices may support wrongdoing such as by fostering climate change, perpetuating oppression in the developing world, or benefiting from the avoidable suffering of nonhuman animals. It is unclear what sort of reasons these remote consequences present, especially in conditions of uncertainty. Ethicists commonly warn that ignorance does not necessarily exculpate or release from compensatory burdens for wrongdoing. Moreover at least sometimes, the demandingness of justice might not cancel or defeat the reasons it provides. Sorting out (...) how to forbear or repair injustice (and even how to begin to do these) may be daunting. After discussing how ignorance of moral or empirical considerations bears on blame or praise, I explore whether and how performing or being disposed to provide moral repair might address the demands of justice in light of uncertain remote causes and consequences. I reject the claim that morally conscientious persons must always seek to prevent injustice. (shrink)