Dr Taylor's book analyses the disease concept as it developed in medical history and seeks to clarify it with the help of concepts largely derived from logical class theories. A solution is proposed to the problem of how to distinguish between the class of 'patients' and the class of 'healthy persons' which corresponds to the actual diagnostic practices of doctors. The earliest theories of disease postulated concrete entities which exist independently of the body. The notion of disease entity has (...) lost its original ontological connotations and instead its important feature has become the possession of a unitary and self-contained character. Dr Taylor describes the modern theories as essentially 'reactive' in character, that is the symptoms of a disease are the bodily reactions to the 'noxae'. After seeing the subject in its historical content, Dr Taylor goes on to discuss in detail the notion of the classification of diseases, making extensive use of modern views on the logic of classes. (shrink)

The clinical empiricism of Thomas Sydenham (1624–1689) and his definition of especie morbosae represented a substantial turn in the medicine of his time. This turn supposed the shift towards an ontological conception of diseases, from a qualitative to quantitative interpretation. Sydenham’s clinical proposal had a great influence on empiricism philosophical thinking, particularly in John Locke and his delimitation of knowledge. The dialogue between medicine and philosophy, set out by Sydenham-Locke, reactivates the problem of the clinical and theoretical foundations (...) of medical thought, as well as the limits of scientific knowledge. Similar to problem exposed in the Hippocratic treatise On ancient medicine, seventeenth-century medicine seeks its epistemological foundations and the solution to its difficulties in clinical experience, probability and analogy. The aim of this work is to show the Sydenham’s contribution to one of the great controversies between medicine and philosophy. (shrink)

This paper highlights the fundamental difference in the criteria adopted to explain original intentionality, which is the basic stratum of intentional phenomena, between the mentalist mainstream and the minority inspired by the rejection of the Myth of the Given. Among the attempts on the latter, inferentialism has become a view of particular interest. According to inferentialism, full intentionality is a feature of cognitive subjects who participate in normative discursive practice. Therefore, the criteria to which the basic intentionality of the mind (...) can be attributed are fundamentally linguistic and not mentalist; for example, perception alone is not sufficient to ground full intentional states. This situation is an interesting challenge to mainstream intentionalism. Furthermore, it can be argued that this view can be a good basis to develop a different conception of collective intentionality in social ontology. In fact, inferentialism makes use of the basic normative notion of discursive commitment to track and evaluate the inferential moves of speakers. This notion can be easily extended hypothetically in the direction of the idea of a ‘joint commitment’ developed by Margaret Gilbert. In what follows, a number of questions and remarks are raised as a first explorative attempt. The role that language plays in social ontology through this approach is of particular interest because of its strict connection with collective intentionality: it is an ‘active’ institution (maybe a meta-institution), the medium and the practice to create and establish other institutions. (shrink)

Organismal death is foundational to the evolution of life, and many biological concepts such as natural selection and life history strategy are so fashioned only because individuals are mortal. Organisms, irrespective of their organization, are composed of basic functional units—cells—and it is our understanding of cell death that lies at the heart of most general explanatory frameworks for organismal mortality. Cell death can be exogenous, arising from transmissible diseases, predation, or other misfortunes, but there are also endogenous forms of (...) death that are sometimes the result of adaptive evolution. These endogenous forms of death—often labeled programmed cell death, PCD—originated in the earliest cells and are maintained across the tree of life. Here, we consider two problematic issues related to PCD (and cell mortality generally). First, we trace the original discoveries of cell death from the nineteenth century and place current conceptions of PCD in their historical context. Revisions of our understanding of PCD demand a reassessment of its origin. Our second aim is thus to structure the proposed origin explanations of PCD into coherent arguments. In our analysis we argue for the evolutionary concept of PCD and the viral defense-immunity hypothesis for the origin of PCD. We suggest that this framework offers a plausible account of PCD early in the history of life, and also provides an epistemic basis for the future development of a general evolutionary account of mortality. (shrink)

The Neurological Disease Ontology (ND) is being developed to provide a comprehensive framework for the representation of neurological diseases (Diehl et al., 2013). ND utilizes the model established by the Ontology for General Medical Science (OGMS) for the representation of entities in medicine and disease (Scheuermann et al., 2009). The goal of ND is to include information for each disease concerning its molecular, genetic, and environmental origins, the processes involved in its etiology and realization, as well as its clinical (...) presentation including signs and symptoms. (shrink)

The article aims at elaborating a non-speculative concept of social pathology. In the first section, various conceptualizations (e.g. Habermas, Honneth) are critically revaluated. It is argued that (a) applying the originally medical concept of ‘pathology’ on social entities has untenable connotations (due to the lacking social equivalent of death); (b) grounding social pathology on the level of ‘social suffering’ is not in accordance with the actors’ horizon shaped by biomedical- and psy-discourses. To avoid these dead-ends, social pathologies are (...) reinterpreted as structural distortions causing diseases or mental disorders. To refine this initial definition, in the second section, Merleau-Ponty’s concept of chiasm is used as an ontological framework translating between medical and social diagnoses. The proposed concept of social pathology refers to those patterns of disrupted pre-intentional, intentional and mediated intertwining, which manifest as ill or psychopathological chiasm. In the third section, two case studies are elaborated: the intersubjective structures of depressed and asthmatic chiasm. Finally, the implications for critical theory and praxis are overviewed. (shrink)

The goal of this paper is two-fold: first, to emphasize causality in disease ontology and knowledge representation, presenting a general and cursory discussion of causality and causal chains; and second, to clarify and develop the River Flow Model of Diseases (RFM). The RFM is an ontological account of disease, representing the causal structure of pathology. It applies general knowledge of causality using the concept of causal chains. The river analogy of disease is explained, formal descriptions are offered, (...) and the RFM disease definition is refined by describing causal chains in terms of causal relations. The definition is updated to coincide with the actual RFM classes found in its upper-level ontology, YAMATO, which brings to light some challenges in developing both YAMATO and the RFM. The RFM is also discussed in relation to another ontological account of disease. Strategies are offered toward interoperability between these theories. (shrink)

The essay attempts to delineate how Maurice Merleau-Ponty’s phenomenology of perception can be applied to theories of sign processes, and how it reworks the framework of the phenomenalist conception of communication. His later philosophy involved a reformulation of subjectivity and a resolution of the subject/object dualism. My claim is that this non-reductionist theory of perception reveals a different view of nature as we experience it in an expressive and meaningful interaction. The perspective that another living being has and communicates entails (...) a form of depth, the invisible dimension of the visible or audible. These two aspects of perception and dialogue are intertwined in a dialectic of presence and absence, so that sense arises in the perceptual field rather than in subjectivity. This, I argue, is the most fundamental result of his theory. The origination of meaning in the workings of the chiasm of visible and invisible in perception opens up an objective sense of intersubjective nature. The essay also deals with the role of the phenomenological reduction; a suspension of beliefs and existence claims in experience. The reduction enables us to take a step back and look more closely at our understanding of nature in light of the historical and cultural influence on our thinking. (shrink)

Anthropology is the study of the origin of the man. It is basically concern with the concept of _Homo__ __sapiens_, and it is scientifically questioning what are human physical traits as well how do men behave and the variation among different groups of human with his social and cultural dimensions. Ontology is a subfield in traditional philosophy which is mainly focuses on the nature of being, existence or reality as such. There are some similarities and differences among these (...) two areas. However when we deeply study the philosophical basis of the anthropology it is proof that it was derived from ontology. Anthropology discusses the social and cultural world or the physical entity of human nature. Ontology focuses the invisible aspect of human nature along with the ultimate reality. Therefore, it has a metaphysical aspect of human being; this philosophical notion has in fact, contributed to the development of the subject of anthropology. The present modern day has given very little attention to this philosophical combination of ontolog y to anthropology, rendering further investigation into the philosophical roots of anthropology. This research paper seeks to evaluate the relationship between ontology and anthropology by paying attention to the ontological arguments about the concept of man and human nature within Greek and modern western thoughts, in comparing with modern anthropological arguments. (shrink)

In a Realist ontology relations are subsisting or existing entities distinct from ordinary things. Idealists claim that the notion of relations is subject to a vicious infinite regress. Nominalists claim that relations are particularized instances. In an attempt to search for the roots of a Realist conception of relations and to meet these challenges I investigate Plato's conception of relations in the Phaedo. ;Against the current of a majority of Plato scholars, Castaneda finds evidence for a distinction between relations and (...) properties at Phaedo 102 b-d. I enter the debate on Castaneda's side and find support for his interpretation of the passage in the context of the dialogue as a whole. The relation--quality distinction resolves the paradox of Simmias being both taller than Socrates and shorter than Phaedo at the same time, since Plato possesses relational characteristics of tallness and shortness, which are not contraries unlike the the contrary properties of hot and cold which could not coexist in an individual. Gallop offers the alternative essence--accident distinction which also resolves the paradox since tallness and shortness as accidents may coexist. The latter distinction however Aristotelianizes Plato. I have shown how the essence--accident distinction is incompatible with Plato's theory of Forms, as it leads to such odd conclusions as the admittance of accidental Forms. ;Castaneda claims that Plato reduces relations to Form-chains in which individuals participate in pairs. I offer the alternative of Plato's positing of relational Forms as distinct from monadic Forms. I survey the corpus of Platonic dialogues in search of support for the distinction between relations and properties. I find that in the Statesman there is a distinction between two types of Forms which generates the distinction between monadic Forms and relational Forms. ;I conclude that there is ample evidence in Plato's dialogues and in Aristotle's assessment of Plato to ascribe this distinction to Plato. Plato's explanation of relations in terms of Forms, which have the highest grade of reality for him, sets up the basis for any Realist theory of relations--for reductionist theories reducing relations to relational properties or some other subsisting entities, as well as for the irreducible concept of relations as abstract subsisting entities. (shrink)

What are the effects of our environment on human development and the next generation? Numerous studies have provided ample evidence that a healthy environment and lifestyle of the mother is important for her offspring. Biological mechanisms underlying these environmental influences have been proposed to involve alterations in the epigenome. Is there enough evidence to suggest a similar contribution from the part of the father? Animal models provide proof of a transgenerational epigenetic effect through the paternal germ line, but can this (...) be translated to humans? To date, literature on fathers is scarce. Human studies do not always incorporate appropriate tools to evaluate paternal influences or epigenetic effects. In reviewing the literature, I stress the need to explore and recognize paternal contributions to offspring's health within the Developmental Origins of Health and Disease hypothesis, and coin this new concept the Paternal Origins of Health and Disease paradigm. A better understanding of preconceptional origins of disease through the totality of paternal exposures, or the paternal exposome, will provide evidence-based public health recommendations for future fathers. A father's hereditary contribution exceeds that of his DNA sequence. The environment can regulate systems such as the sperm epigenome, which is inheritable as well and may steer the genome and health status of his offspring. We here suggest a new concept, the Paternal Origins of Health and Disease, as part of the DOHaD theory. (shrink)

The concept of formal ontology was first developed by Husserl. It concerns problems relating to the notions of object, substance, property, part, whole, predication, nominalization, etc. The idea of formal ontology is present in many of Husserl?s works, with minor changes. This paper provides a reconstruction of such an idea. Husserl?s proposal is faced with contemporary logical orthodoxy and it is presented also an interpretative hypothesis, namely that the original difference between the general perspective of usual model theory and (...) formal ontology is grounded in the fact that this latter starts from an intended interpretation and not from the set of all the possible interpretations. (shrink)

Environmental historians are not sufficiently aware of the extent to which mid twentieth-century thinkers turned to medical geography—originally a nineteenth-century area of study—in order to think through ideas of ecology, environment, and historical reasoning. This article outlines how the French–Croatian Mirko D. Grmek, a major thinker of his generation in the history of medicine, used those ideas in his studies of historical epidemiology. During the 1960s, Grmek attempted to provide, in the context of the Annales School’s research program under the (...) leadership of Fernand Braudel, a new theoretical framework for a world history of disease. Its development was inspired by several sources, most notably the French–American Jacques M. May, who was then pioneering an opening up of medical geography and movement towards the concept of disease ecology. The cornerstone of Grmek’s “synthetic approach” to the field was the notion of “pathocenosis”. The diverse uses of this notion in the course of time—from his early agenda focused on a longue durée history of diseases in Western Antiquity to his last, relating to the new epidemiological threat of emerging infectious diseases, specifically HIV/aids—enables us firstly, to note how concepts of ecology sat uneasily alongside those of medical geography; secondly, to assess the reach and limits of his theoretical contribution to historical epidemiology; and thirdly, to understand better the uneven fortunes of his concept of pathocenosis at the end of the twentieth and beginning of the twenty-first centuries. (shrink)

In this article, I draw on my fieldwork creating protein models of hepatitis B at a biotech laboratory to think through how to approach the body and disease from ontological and phenomenological perspectives. I subsequently draw on Mariella Pandolfi’s work on how bodies can be made to suffer history and Paul Farmer’s work on global tuberculosis disparities to explore ways of analysing embodied activity as a means of identifying and clinically addressing enactments of social inequality and disease. I also (...) introduce Merleau-Ponty’s phenomenological concept of ‘flesh’ as a conceptual heuristic that allows us to understand the meaningful structuring of ontological worlds beyond our own. As I argue, bringing these perspectives together not only allows us to re-envision what an effective disease treatment should be in diverse medical contexts, but also how to better understand health disparities and the nature of disease itself. (shrink)

[In Czech] Merleau-Ponty’s analyses of the pathology of perception show “objective” and “subjective” events have sense for the living body only in relation to its whole equilibrium, that is, to how it organises itself overall and how it thus “meets” those events. If we apply this conception to Husserl’s example of two mutually-touching hands of one body we must then state not that we perceive here a coincidence of certain subjective sensations with certain objective qualities, but rather that my body, (...) in the sense of an object, results from the restructuralisation of the whole field of the body accomplished by the the body as the performer of perceptual intentions. The body-object, and for the same reasons also the body-subject, is therefore the product of the analysis of the body in the sense of a field of structuralisation or polarisation, not its original phenomenological “stratum”, as in Husserl. If the body understands itself as perceptible only by a change of its own structure, inasmuch as it is a certain field of structuralisation, then the "external” thing, which is likewise a pole of such grasping, must belong to the same ontological “field” as the body. Merleau-Ponty’s “flesh”, that is the circularity between questioning of perception and answering of the perceived, is thus a phenomenon appearing beyond the boundary of the body as a singular being. This fact allows the concept of flesh to be extended and to be understood as an “element”, that is, as a dimension in which individual beings appear. [In Czech language.]. (shrink)

[In Czech] Merleau-Ponty holds that Husserl’s descriptions of the body go beyond the conceptual framework of subject-object ontology to which his philosophy is usually thought to conform. Merleau-Ponty says of his own philosophy that it is founded on the circularity in the body; that is, on the fact that from the ontological point of view, perception and availability to be perceived, are one and the same in the body. The inseparability of these two aspects of the body he calls (...) "flesh" (chair). According to Husserl, I perceive my body such that in a certain perceived object I also co-perceive sensations roused by the perception of that object – I observe the “consequential parallel” between two series of objective and subjective phenomena. Husserl argues that the unity of the body should be descrived as a double unity, and the body as a subject-object. In this article I analyse Husserl’s example of two hands of the same body touching mutually and, following Merleau-Ponty, I attempt to show that the body can appear to itself as an object only on the basis of a differentiation of the body as a particular field of perceiving. The body as a double unity of subject and object is therefore grounded in the body as a pre-objective and pre-subjective field; that is, in flesh as Merleau-Ponty understands it. This is also the point of departure for an original conception of ontology as we find it in his later philosophy. [In Czech language.]. (shrink)

ABSTRACT The use of broad consent for genomics research raises important ethical questions for the conduct of genomics research, including relating to its acceptability to research participants and comprehension of difficult scientific concepts. To explore these and other challenges, we conducted a study using qualitative methods with participants enrolled in an H3Africa Rheumatic Heart Disease genomics study (the RHDGen network) in Zambia to explore their views on broad consent, sample and data sharing and secondary use. In-depth interviews were conducted with (...) RHDGen participants (n = 18), study staff (n = 5) and with individuals who refused to participate (n = 3). In general, broad consent was seen to be reasonable if reasons for storing the samples for future research use were disclosed. Some felt that broad consent should be restricted by specifying planned future studies and that secondary research should ideally relate to original disease for which samples were collected. A few participants felt that broad consent would delay the return of research results to participants. This study echoes findings in other similar studies in other parts of the continent that suggested that broad consent could be an acceptable consent model in Africa if careful thought is given to restrictions on re-use. (shrink)

On ‘Mismatch’ and ‘Metabolic Ghettos:’ The Conceptualization of Global Health Differences in Research on the Developmental Origins of Health and Disease. Epigenetic approaches to human health have received growing attention in the past two decades. They allow to view the development of human organisms as plastic, i.e. as open to influences from the social and material environment such as nutrition, stress, and trauma. This has lent new credence to approaches in biomedicine that aim to draw attention to the importance of (...) development for later life health. Some scholars in the social sciences and humanities have welcomed such approaches as a departure from gene‐centric perspectives and as an opportunity for highlighting the social and political determinants of health and illness. Others have warned that they might lead to new forms of biological reductionisms and determinisms. In this article, we explore how research on developmental plasticity addresses and articulates global health disparities, specifically in the context of postcolonial India. We discuss two prominent approaches from the field of Developmental Origins of Health and Disease (DOHaD) that build on epigenetic perspectives on health and illness and view different global rates of disease susceptibility as the result of developmental processes: first, the ‘mismatch paradigm’ by Peter Gluckman and Mark Hanson and second, the ‘metabolic ghetto’ concept by Jonathan Wells. We highlight how both approaches render historical and social factors meaningful for the development of global health disparities, but emphasize how they at the same time remain prone to determinisms and reductionisms reminiscent of a gene‐centric perspective. DOHaD actors themselves are critical of these tendencies, and in conclusion we explore novel opportunities for interdisciplinary collaborations enabled by this critical potential. (shrink)

Based on the philosophy of Martin Heidegger the article presents the possibility of actualizing Heidegger’s main question about the meaning of Being in the context of the analysis of so-called “a priori perfect.” During the development of fundamental ontology in the second half of the 1920s, Heidegger ponders the approach to Being in the history of philosophy and identifies such a feature of Being as a priori, a kind of antecedence of Being in relation to being. Although tradition invariably understands (...) Being in this way, in it, according to Heidegger, the question is no longer raised either about the sense of such antecedence, or about the temporal basis of this sense, and therefore a priori as the essential character of Being is left in total oblivion. We suggest that it is the problematization of apriority in its temporal origin that can contribute to resolving Heidegger’s fundamental philosophical question of time as the transcendental horizon of any concept of Being that precedes being. In this precedence there is a cherished temporal moment, the comprehension of which allows us to develop the “basic question of metaphysics” about the relationship of Being and time in a more concrete way than Heidegger’s four main themes of the question of Being: the ontological difference; the basic articulation of Being ); the truth-character of Being; the possible modifications of Being and the unity of Being’s variety. Revealing a priori question as the central question of all Heideggers thinking before the “Turn” we attempt to update this question and justify the need for its renewal on the basis of a fundamental ontology. With this task we relate the question of the essence of philosophy in general in its existential-temporal concept since philosophy appears as a temporality-based possible of the questioning return to the “earlier”: to the essential structures of being, knowledge, Being, Dasein. Our analysis is based on the following decisions: Being in relation to being is always pre-understood as “earlier,” and in this understanding a temporal definition operates, hence the main question of fundamental ontology about the relation of Being and time can be developed or at least clarified through the problem of meaning of a priori. The question of the meaning of the “earlier” and of the temporal basis for understanding Being as “earlier,” a priori, is concretized into the question of the conditions for the possibility of any ontology, including the fundamental ontology, which raises the question of the earlier in relation to Being and therefore “lives” in the light of the understanding of the “earlier” as such. This reflexive foundation of the fundamental ontology from itself is a necessary stage on the way of developing its project, if we remember that the main “duty” of the philosopher is to clarify “our inner nature” for the sake of opening the boundaries and conditions of the possibility of philosophy. The conclusion is that the possibilities of fundamental ontology in making sense of Being, time, and philosophy in general are far from exhausted, but await the questions that actualize them and new readings that allow to see the hidden richness of Heidegger’s thought. (shrink)

The use of broad consent for genomics research raises important ethical questions for the conduct of genomics research, including relating to its acceptability to research participants and comprehension of difficult scientific concepts. To explore these and other challenges, we conducted a study using qualitative methods with participants enrolled in an H3Africa Rheumatic Heart Disease genomics study in Zambia to explore their views on broad consent, sample and data sharing and secondary use. In-depth interviews were conducted with RHDGen participants, study staff (...) and with individuals who refused to participate. In general, broad consent was seen to be reasonable if reasons for storing the samples for future research use were disclosed. Some felt that broad consent should be restricted by specifying planned future studies and that secondary research should ideally relate to original disease for which samples were collected. A few participants felt that broad consent would delay the return of research results to participants. This study echoes findings in other similar studies in other parts of the continent that suggested that broad consent could be an acceptable consent model in Africa if careful thought is given to restrictions on re-use. (shrink)

The article attempts to highlight the development of the unity of medicine and philosophy in the context of combating epidemics of two early Greek thinkers Epimenides and Empedocles. The idea that Epimenides adheres to the divine origin of the disease is justified, but at the same time, in the process of ritual purification from the plague, it attracts elements of the Pythagorean view of healing, as well as close to Indo-Iranian traditions of the time. It is proved that in (...) the course of the development of ancient thought, the view of the disease also evolves “from myth to logos”, which leads to the understanding of this phenomenon in Empedocles as an ontological problem. Accordingly, it has been established that, for the Sicilian philosopher, mass diseases (epidemics) are caused primarily by the fact that he is more prevalent in the world. If the society is engulfed by hatred and malice, then diseases will inevitably emerge and increase. Instead, overcoming and disappearing of epidemics are possible because peace and harmony between people will prevail. The author substantiates the thesis that helping residents to overcome epidemics in various ancient cities, testifies to the great importance of the early Greek thinkers, who combined not only reflection but also praxis. (shrink)

In the whole universe, from the lowest beings to the highest ones, love permeates through the entire world of existence. Love is one of the hallmarks and perfections of existence in animals. This survey was done to illuminate and explain Mullah Sadra’s ontological viewpoint on the entity of sentiments and the inborn and innate love in the existence of non-human animals. The analytic and descriptive method was used to conduct this study and research. An animal is one of the (...) creatures in the essence of the existence that possesses its own perfect attributes. Animals have souls, the effects of which are life, perception, free choice, and emotions. Animals have an order for their existence, and they are attributed with perfection to the extent of their intensity and weakness. That is to say, all animals are not at the same level. Their perfection is also the same as their existence is. There is life, perception, and love in animals, but it depends on their proportion of existence. All animals are in love, but every animal having the highest share of its rank enjoys more love. Mullah Sadra’s ontological principles in proving the existence and flow of love in animals are that the existence is ‘original,’ ‘non-composite,’ ‘equivocal,’ and ‘coextensive’ with life, conception and love, and ‘God, the Almighty, is the true Beloved of all beings including animals’ souls.’ Evolutionarily, animals can only move to the point where humanity of human beings begins. (shrink)

BackgroundVulnerability is a key concept in traditional and contemporary bioethics. In the philosophical literature, vulnerability is understood not only to be an ontological condition of humanity, but also to be a consequence of contingent factors. Within bioethics debates, vulnerable populations are defined in relation to compromised capacity to consent, increased susceptibility to harm, and/or exploitation. Although vulnerability has historically been associated with older adults, to date, no comprehensive or systematic work exists on the meaning of their vulnerability. To (...) fill this gap, we analysed the literature on aged care for the meaning, foundations, and uses of vulnerability as an ethical concept.MethodsUsing PRISMA guidelines, we conducted a systematic review of argument-based ethics literature in four major databases: PubMed, Embase®, Web of Science™, and Philosopher’s Index. These covered biomedical, philosophy, bioethical, and anthropological literature. Titles, abstracts, and full texts of identified papers were screened for relevance. The snowball technique and citation tracking were used to identify relevant publications. Data analysis and synthesis followed the preparatory steps of the coding process detailed in the QUAGOL methodology.ResultsThirty-eight publications met our criteria and were included. Publication dates ranged from 1984 to 2020, with 17 publications appearing between 2015 and 2020. Publications originated from all five major continents, as indicated by the affiliation of the first author. Our analyses revealed that the concept of vulnerability could be distinguished in terms of basic human and situational vulnerability. Six dimensions of older adults’ vulnerability were identified: physical; psychological; relational/interpersonal; moral; sociocultural, political, and economic; and existential/spiritual. This analysis suggested three ways to relate to older adults’ vulnerability: understanding older adults’ vulnerability, taking care of vulnerable older adults, and intervening through socio-political-economic measures.ConclusionsThe way in which vulnerability was conceptualised in the included publications overlaps with distinctions used within contemporary bioethics literature. Dimensions of aged care vulnerability map onto defining features of humans, giving weight to the claim that vulnerability represents an inherent characteristic of humans. Vulnerability is mostly a value-laden concept, endowed with positive and negative connotations. Most publications focused on and promoted aged care, strengthening the idea that care is a defining practice of being human. (shrink)

The purpose of this paper is to discover an important contribution of classical Chinese ontological conceptions for the future world philosophy and the modern human Weltanschauung in the process of its globalization. Through a brief mosaic of a development of mutual Euro-Chinese encounters, from the Middle Ages to the present, the paper presents the view that both Chinese and European philosophical complexes were quite indispensable parts of the history of world philosophy; and in the future, perhaps, they will be (...) the leading factors that decide (in their serious confrontation) the basic determination of the roots of the global world metaphilosophy. At the same time the author, long having carried out scholarly research and published translations of Laozi 's Dao De Jing, Confucius' Lunyu, the Books of Xunii, Huang Lao, Huang di si jing, etc., wants to demonstrate, on the basis of specific examples of original Chinese dialectical metaphysics, their unique philosophical value for the future world philosophy and the modern human Weltanschauung. (shrink)

Living things are often plastic during their early development and are moulded by the environment. Many human fetuses have to adapt to a limited supply of nutrients, and in doing so they permanently change their physiology and metabolism. These programmed changes may be the origins of a number of diseases in later life, including coronary heart disease, stroke, diabetes and hypertension.

The paper discusses the parallels between late Heidegger's view of the world as a fourfold unity of earth, heavens, the divine and the mortal (the Geviert), and a passage in Plato's Gorgias (507e–508a) where the world (kosmos) is conceived of in a similar way. It is argued, first, that the Gorgias passage is not an isolated remark but rather a point where a number of important Platonic insights come together, and second, that Heidegger was well acquainted with these insights and (...) pointed out their ontological significance on various occasions. (shrink)

In this paper, I focus on the concept of intuition in Schelling’s philosophy. More specifically, I show how Schelling attributes to intuition an ontological value by essentially relating it to freedom and primal Being. Indeed, for Schelling intuition is both the main instrument of philosophy and the highest product of freedom, by which we attain the so-called “God’s-eye point of view” and concretely grasp things in their immediate existence. That is, through intuition it is possible to grasp the (...) absolute and original unity of the principles, namely of being and thought, subject and object and freedom and necessity. Accordingly, I argue that Schelling’s conception of intuition, rather being a merely theoretical speculation, is aimed at demonstrating the immanent nature of Being, which is one of the key points in Schelling’s philosophy. (shrink)

In this paper, I focus on the concept of intuition (Anschauung) in Schelling’s philosophy. More specifically, I show how Schelling attributes to intuition an ontological value by essentially relating it to freedom and primal Being (Ursein). Indeed, for Schelling intuition is both the main instrument of philosophy and the highest product of freedom, by which we attain the so-called “God’s-eye point of view” and concretely grasp things in their immediate existence. That is, through intuition it is possible to (...) grasp the absolute and original unity of the principles, namely of being and thought, subject and object and freedom and necessity. Accordingly, I argue that Schelling’s conception of intuition, rather being a merely theoretical speculation, is aimed at demonstrating the immanent nature of Being, which is one of the key points in Schelling’s philosophy. (shrink)

Philosophical discussions of health and disease have traditionally been dominated by a debate between normativists, who hold that health is an inescapably value-laded concept and naturalists, such as Christopher Boorse, who believe that it is possible to derive a purely descriptive or theoretical definition of health based upon biological function. In this paper I defend a distinctive view which traces its origins in Aristotle's naturalistic ethics. An Arisotelian would agree with Boorse that health and disease are ubiquitous features of (...) the natural world and thus not mere projections of human interests and values. She would differ from him in rejecting the idea that value is a non-natural quality. I conclude my discussion with some comments of the normative character of living systems. (shrink)

The development of phenomenology in nineteenth‐century German philosophy is that of a particular stream within the larger historical‐philosophical complex of Austro‐German philosophy. As the “grandfather of phenomenology” resp. the “disgusted grandfather of phenomenology,” but also as the key figure on the “Anglo‐Austrian Analytic Axis”, Brentano is at the source of the two main philosophical traditions in twentieth‐century philosophy. This chapter focuses mainly on his place in nineteenth‐century European philosophy and on the central themes and concepts in his philosophy that were (...) determinant in the development of the philosophy of his most gifted student: Edmund Husserl. Despite the variety of stances which Brentano expressed on ontology, metaphysics, and psychology over the course of his career, the five general principles remain central to his whole philosophy throughout: they have an important place in what could be called Brentano's philosophical worldview or system. By extension, they also are essential to his conception of phenomenology. (shrink)

The development of phenomenology in nineteenth‐century German philosophy is that of a particular stream within the larger historical‐philosophical complex of Austro‐German philosophy. As the “grandfather of phenomenology” resp. the “disgusted grandfather of phenomenology,” but also as the key figure on the “Anglo‐Austrian Analytic Axis”, Brentano is at the source of the two main philosophical traditions in twentieth‐century philosophy. This chapter focuses mainly on his place in nineteenth‐century European philosophy and on the central themes and concepts in his philosophy that were (...) determinant in the development of the philosophy of his most gifted student: Edmund Husserl. Despite the variety of stances which Brentano expressed on ontology, metaphysics, and psychology over the course of his career, the five general principles remain central to his whole philosophy throughout: they have an important place in what could be called Brentano's philosophical worldview or system. By extension, they also are essential to his conception of phenomenology. (shrink)

ABSTRACT The use of broad consent for genomics research raises important ethical questions for the conduct of genomics research, including relating to its acceptability to research participants and comprehension of difficult scientific concepts. To explore these and other challenges, we conducted a study using qualitative methods with participants enrolled in an H3Africa Rheumatic Heart Disease genomics study (the RHDGen network) in Zambia to explore their views on broad consent, sample and data sharing and secondary use. In-depth interviews were conducted with (...) RHDGen participants (n = 18), study staff (n = 5) and with individuals who refused to participate (n = 3). In general, broad consent was seen to be reasonable if reasons for storing the samples for future research use were disclosed. Some felt that broad consent should be restricted by specifying planned future studies and that secondary research should ideally relate to original disease for which samples were collected. A few participants felt that broad consent would delay the return of research results to participants. This study echoes findings in other similar studies in other parts of the continent that suggested that broad consent could be an acceptable consent model in Africa if careful thought is given to restrictions on re-use. (shrink)

The convergence of biomedical sciences with nanotechnology as well as ICT has created a new wave of biomedical technologies, resulting in visions of a ‘molecular medicine’. Since novel technologies tend to shift concepts of disease and health, this paper investigates how the emerging field of molecular medicine may shift the meaning of ‘disease’ as well as the boundary between health and disease. It gives a brief overview of the development towards and the often very speculative visions of molecular medicine. Subsequently (...) three views of disease often used in the philosophy of medicine are briefly discussed: the ontological or neo-ontological, the physiological and the normative/holistic concepts of disease. Against this background two tendencies in the field of molecular medicine are highlighted: (1) the use of a cascade model of disease and (2) the notion of disease as a deviation from an individual pattern of functioning. It becomes clear that molecular medicine pulls conceptualizations of disease and health in several, partly opposed directions. However, the resulting tensions may also offer opportunities to steer the future of medicine in more desirable directions. (shrink)

Traditionally, species have been treated by biologists and philosophers as natural kinds. However, this conception of species has posed several problems for evolutionary theory. For example, biologists have been hard pressed to find traits had by all and only the members of a species. This has caused some philosophers to doubt that evolutionary theory is a scientific theory. ;In an effort to resolve such problems, Michael Ghiselin and David Hull have argued that species are not kinds but individuals. A number (...) of authors have adopted this conclusion. Some have even gone on to argue that besides showing that species are not kinds, the thesis that species are individuals has other ramifications for evolutionary theory. For example, the thesis is said to lend support to the Theory of Punctuated Equilibrium. ;In my dissertation, I argue that while species are not kinds, most species are not individuals either. Furthermore, even if all species were individuals, the alleged ramifications are not forthcoming. ;More specifically, in Chapter One I review the arguments against species being kinds and the recent replies to those arguments. I also examine the nature of kinds and contend that the original arguments against species being kinds still stand. ;In Chapter Two, I turn to the metaphysics of individuality. I argue that mere spatiotemporal continuity and a rough similarity among the constituents of an entity are insufficient for it to be an individual. The constituents of an individual must be appropriately causally connected as well. ;With this requirement, I return to species in Chapter Three. Most species consist of subpopulations which are not causally connected in any biological fashion. Because of this, and other reasons, I argue that most species are not individuals. ;In the final chapter, I point out that the result of the previous chapter goes against the claim that what distinguishes species from higher taxa is that species and not higher taxa are individuals. I also argue that even if all species were individuals, their individuality does not support the Theory of Punctuated Equilibrium. Finally, some authors maintain that a unit of selection must be an individual. I argue that there is no such requirement on units of selection. (shrink)

The Center for Disease Control and Prevention’s Active Bacterial Core Surveillance (CDC ABCs) Program is a collaborative effort betweeen the CDC, state health departments, laboratories, and universities to track invasive bacterial pathogens of particular importance to public health [1]. The year-end surveillance reports produced by this program help to shape public policy and coordinate responses to emerging infectious diseases over time. The ABCs case report form (CRF) data represents an excellent opportunity for data reuse beyond the original surveillance purposes.

Identifying the necessary and sufficient conditions for individuating and classifying diseases is a matter of great importance in the fields of law, ethics, epidemiology, and of course, medicine. In this paper, I first propose a means of achieving this goal, ensuring that no two distinct disease-types could correctly be ascribed to the same disease-token. I then posit a metaphysical ontology of diseases—that is, I give an account of what a disease is. This is essential to providing the most (...) effective means of interfering with disease processes. Following existing work in the philosophy of medicine and epidemiology (primarily Christopher Boorse; Caroline Whitbeck; Alexander Broadbent), philosophy of biology (Joseph LaPorte; D.L. Hull), conditional analyses of causation (J.L. Mackie; David Lewis), and recent literature on dispositional essentialism (Stephen Mumford and Rani Anjum; Alexander Bird), I endorse a dispositional conception of disease. Following discussion of various conceptions of disease-identity, their relations to the clinical and pathological effects of the diseases in question, and how diseases are treated, I conclude (i) that diseases should be individuated by their causes, and (ii) that diseases are causal processes best seen as simultaneously acting sequences of mutually manifesting dispositions. (shrink)

On the Origin of Objects is the culmination of Brian Cantwell Smith's decade-long investigation into the philosophical and metaphysical foundations of computation, artificial intelligence, and cognitive science. Based on a sustained critique of the formal tradition that underlies the reigning views, he presents an argument for an embedded, participatory, "irreductionist," metaphysical alternative. Smith seeks nothing less than to revise our understanding not only of the machines we build but also of the world with which they interact. Smith's ambitious project (...) begins as a search for a comprehensive theory of computation, able to do empirical justice to practice and conceptual justice to the computational theory of mind. A rigorous commitment to these two criteria ultimately leads him to recommend a radical overhaul of our traditional conception of metaphysics. Everything that exists - objects, properties, life, practice - lies Smith claims in the "middle distance," an intermediate realm of partial engagement with and partial separation from, the enveloping world. Patterns of separation and engagement are taken to underlie a single notion unifying representation and ontology: that of subjects' "registration" of the world around them. Along the way, Smith offers many fascinating ideas: the distinction between particularity and individuality, the methodological notion of an "inscription error," an argument that there are no individualswithin physics, various deconstructions of the type-instance distinction, an analysis of formality as overly disconnected ("discreteness run amok"), a conception of the boundaries of objects as properties of unruly interactions between objects and subjects, an argument for the theoretical centrality of reference preservation, and a theatrical, acrobatic metaphor for the contortions involved in the preservation of reference and resultant stabilization of objects. Sidebars and diagrams throughout the book help clarify and guide Smith's highly original and compelling argument. A Bradford Book. (shrink)

In recent years, there has been considerable debate concerning the origin of divine Christology. Nevertheless, the proposed theories are beset with problems, such as failing to address the evidence of widespread agreement among the earliest Christians concerning divine Christology, and the issues related to whether Jesus' intention was falsified. This book offers a new contribution by addressing these issues using transdisciplinary tools. It proposes that the earliest Christians regarded Jesus as divine because a sizeable group of them perceived that (...) Jesus claimed and showed himself to be divine, and thought that God vindicated this claim by raising Jesus from the dead. It also provides a comprehensive critique of alternative proposals, and synthesizes their strengths. It defends the appropriateness and merits of utilizing philosophical distinctions (e.g. between ontology and function) and Trinitarian concepts for explaining early Christology, and incorporates comparative religion by examining cases of deification in other contexts. (shrink)

The purpose of this paper is to discover an important contribution of classical Chinese ontological conceptions for the future world philosophy and the modern human Weltanschauung in the process of its globalization. Through a brief mosaic of a development of mutual Euro-Chinese encounters, from the Middle Ages to the present, the paper presents the view that both Chinese and European philosophical complexes were quite indispensable parts of the history of world philosophy; and in the future, perhaps, they will be (...) the leading factors that decide (in their serious confrontation) the basic determination of the roots of the global world metaphilosophy. At the same time the author, long having carried out scholarly research and published translations of Laozi 's Dao De Jing, Confucius' Lunyu, the Books of Xunii, Huang Lao, Huang di si jing, etc., wants to demonstrate, on the basis of specific examples of original Chinese dialectical metaphysics, their unique philosophical value for the future world philosophy and the modern human Weltanschauung. (shrink)

From the origin of ancient Greek philosophy to the philosophy of medieval ages, although it appeared the discussion of "nominalism" and "realism" in medieval times, the exploration of the concept of "objective but non-real" did not get further developed. From the view of the inherent integration of the unity of general rationality on science and philosophy, professor Wu Kun revived the concept of "objective but non-reality" and creatively developed his "philosophy of information" system. Because the existence of (...) "objective but non-reality" is inherently a kind of "crossover" field in the traditional philosophy, it certainty solve the problems of traditional philosophy from the ontology, which will lead to the breakthrough in the fundamental paradigm in philosophy, and the philosophy begin its fundamental turn. (shrink)

From the origin of ancient Greek philosophy to the philosophy of medieval ages, although it appeared the discussion of "nominalism" and "realism" in medieval times, the exploration of the concept of "objective but non-real" did not get further developed. From the view of the inherent integration of the unity of general rationality on science and philosophy, professor Wu Kun revived the concept of "objective but non-reality" and creatively developed his "philosophy of information" system. Because the existence of (...) "objective but non-reality" is inherently a kind of "crossover" field in the traditional philosophy, it certainty solve the problems of traditional philosophy from the ontology, which will lead to the breakthrough in the fundamental paradigm in philosophy, and the philosophy begin its fundamental turn. (shrink)

In this paper I try to show how transcendental logic can be interpreted in light of the distinction between apophantics and formal ontology. Despite the non-Kantian origin of these concepts, my contention is that they can reveal the scope of Kant’s argument regarding the distinction between formal and transcendental logic and the thesis that transcendental logic has a pure a priori content. While common approaches interpret this a priori content of transcendental logic as the content pure forms of aesthetics (...) give, we stress that this content is the a priori concepts of object which are embedded in the logical form of judgments. (shrink)

The great chain of being is an ontological conception in which all beings, from inanimate things to God, are ranked on a scale according to their perfectness. This hierarchical scheme, though widely known in the history of ideas, was systematically addressed by Arthur Lovejoy in 1936. The great chain of being as formulated by Lovejoy is composed of three main principles, whose roots can be found in Plato and Aristotle’s philosophies. These principles are “the principle of plenitude”, “the principle (...) of gradation” and “the principle of continuity.” The first principle, the principle of plenitude, was pointed out in Plato’s philosophy and the latter two, the principle of gradation and the principle of continuity, were addressed in Aristotle’s philosophy. According to Lovejoy, these three principles were systematically addressed in Plotinus’s philosophy and became an essential part of Neo-Platonic cosmology. Platon explains the abundance of beings with reference to the absolute goodness of the God in his famous book Timaios. Accordingly, God has absolute goodness and this attribution has given rise to an abundance of beings as goodness requires the existence of things. The other two principles, the principle of gradation and the principle of continuity, were forwarded by Aristotle and through his works affected Western thought. While the principle of gradation refers to the ranking of beings in a chain based on the criteria of their perfection, the principle of continuity is the natural consequence of that ranking in that all beings share at least a minimum level of similarity. Plotinus synthesized and systematized those three principles as an expression of ranked beings specific to emanation theory and added three hypostasis -One, Nous, and Soul- in addition to the natural world addressed in Aristotle’s works. Therefore, we see that beings were ranked from inanimate things to God in Plotinus’s works. This concept of hierarchical order of beings, the great chain of being, affected many cultures and philosophical ideas from Classical Islamic philosophy to the Western tradition. In this article, we confine our subject to only Western thought, including Medieval Christian theology and philosophy, the Renaissance period, and the Age of Enlightenment as well as a peculiar implication and interpretation of the great chain of being specific to modern times. In every period we will deal with just one thinker and their ideas to demonstrate the effect of the great chain of being on those thinkers’ philosophies and systems. In this context, we examined how Thomas Aquinas used the great chain of being to justify some theological and philosophical matters and tried to show how he utilized the principle of continuity effectively to explain the relationship between matter and soul. Marcilio Ficino, a Neo-Platonist philosopher of the Renaissance period, also used the great chain of being to explain the hierarchical order of beings and their ontological relationship to the perfect being, which is God, placing them in a rising line according to their closeness to God. On the other hand, when we come to the Age of Enlightenment we see that the great chain of being continues to be apparent in some philosophical works. One example is John Locke’s famous book An Essay Concerning Human Understanding. Here Locke tries to make sense of the existence of many species of spirits with reference to the great chain of being, especially by using the principle of continuity. This attempt of justification shows us that the great chain of being, as an old philosophical and ontological concept, was still used even in the Enlightenment. Finally, it would be beneficial to address how the chain of being in question was presented and understood in modern times. Unlike the justification of some philosophical or theological subjects, in modern times the hierarchical structure of the great chain of being has been anachronistically read into the theory of evolution with reference to some medieval Muslim philosophers’ works. This approach, however, springs from the figural similarities between the great chain of being and the theory of evolution, although the contents of both theories are completely different. It would be accepted easily that similarities in figure do not necessitate similarities in content. In short, the great chain of being has been very effectively used in the history of philosophy to justify different subjects in different areas such as philosophy and theology. In this article, we address the usages of the chain in question and trace its effects specific to the Western tradition from the ancient period to modern times. (shrink)

The studies on the history of the notion of “personhood” have largely recognized that Christian thought had a central role in the development and significance of this concept throughout the history of Western civilization. In late antiquity, Christianity used some terms taken from the classic and Hellenistic vocabulary in order to express its own theological content. This operation generated a “crisis” of classical language, namely a semantic transformation in the attempt to address some aspects of reality which were not (...) envisioned by the previous usage of these words. The term person is a paradigmatic example of this process. In fact, from the outset, it played a strategic role in formulating the idea of Incarnation, one of the central doctrines of Christianity. This essay aims to show how, during the first centuries of Christianity, the terms commonly used in order to express the notion of “personhood” became pivotal elements for the formulation of the discourse about the Trinity and progressively acquired new meanings. The analysis focuses only on the initial stage of the elaboration of this concept in Christianity and, based on some of the most significant texts, tries to bring out a series of theoretical problems that may be useful to understand the subsequent debate. In order to do so, the author divides the text in two parts. In the first one, he analyses two features strictly connected to the theological use of the term “persona”, which remained central also when this term was later referred to man. These features are individuality and ontological stability, along with the structurally relational status of personhood. In the second part, the author offers more details about the theology of the Cappadocian Fathers, in particular of Basil of Caesarea, and analyses two sectorial languages—mathematical and iconic language—used by Basil in order to describe the intra-trinitarian relationships. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Basic Concepts of Aristotelian PhilosophyShawn LohtMartin Heidegger. Basic Concepts of Aristotelian Philosophy. Translated by Robert D. Metcalf and Mark B. Tanzer. Bloomington-Indianapolis: Indiana University Press, 2009. Pp. xii + 279. Cloth, $39.95.Previously available as Volume 18 of the Gesamtausgabe [GA], this text contains a lecture course delivered by Heidegger at Marburg during the summer of 1924. Metcalf and Tanzer's translation is its first appearance in English. The editor (...) of this volume in the Gesamtausgabe reports that only a fraction of Heidegger's original course material survives in manuscript form. As a result, much of the text does not originate from Heidegger's own hand. The bulk of it represents a transcription of the lecture course based on multiple independently-recorded, complete sets of student notes in conjunction with Heidegger's extant course papers. However, the resulting text reads as continuously as Heidegger's other better-preserved lecture courses from the 1920s, and should be regarded as a legitimate source for studying early Heidegger. Only the reproduction of Heidegger's notes for the course appears in rough outline form, comprising approximately 50 pages, so readers should not anticipate a text consisting entirely of abbreviated sketches as one sees, for instance, in the recently translated Basic Concepts of Ancient Philosophy (GA 22).The content of the lecture course is not devoted to enumerating the basic Aristotelian concepts per se, but rather to accounting for the phenomenological dimensions of the Greek experience in which conceptuality as such could arise. However, Heidegger does treat most principal concepts of Aristotelian philosophy here, describing the ontological framework from which they originate and their interrelations with one another.Heidegger engages with Kant in the early sections of the course in order to locate the historical solidification of the concept as a guiding idea in philosophy, but he moves to Aristotle quickly on the premise that the decisive germ of conceptuality is exhibited in the Greek discovery of the significance of definitions. In the text that follows, Heidegger takes up central themes in Aristotle in order to unfold Greek being-in-the-world as occurring through language and, particularly, oral discourse. Strong focus is placed on Greek being-there in its everydayness as the hermeneutic for understanding conceptuality.Clear rudiments of the terminology of Being and Time emerge in the course of Heidegger's account of Aristotle. Themes appearing in that later work, including world, being-with-one-another, attunement, fear, and idle talk, inform Heidegger's reading of the Aristotelian account of human nature across the Nicomachean Ethics, Rhetoric, De Anima, and Parts of Animals. Key Aristotelian terms Heidegger develops within this framework include 'prohairesis', 'hexis', 'pathos', and 'nous'. Early formulations of Heidegger's conceptions of logos and aletheia and their fundamental role in Greek experience also permeate his reading. Traces of Heidegger's more mature phenomenology are evident in the lecture course's late sections, in which he takes up the Aristotelian account of motion in the Physics. Here, Heidegger emphasizes the roles of nous as constitutive of the human agent's openness to the world and of kinesis as the fundamental mode in which beings come into view for the Greeks.Notable among the translation choices of Metcalf and Tanzer is their rendering of 'Dasein' and its variants. As they write in the Translators' Preface, Heidegger's use of this term in the lecture course reflects an understanding of Dasein in terms of its there-character. The result places less emphasis on the human subject as a dative agent of manifestation, as one sees in Being and Time, highlighting instead the manner in which Dasein finds itself in the world. This last is expressive of Heidegger's emphatic treatment in the course of conceptuality as tied up with human being-in-the-world.This text will be of vital interest to scholars interested in the genesis of Being and Time and Heidegger's early formulations of its central arguments in the 1920s. The text will also be an important addition to Heidegger's works on Aristotle available in English. The lecture course offers penetrating and incisive accounts of themes in Aristotle that Heidegger neglects or treats only briefly... (shrink)

On the standard interpretation of Metaphysics IX, Aristotle proceeds from the original sense of δύναμις and ἐνέργεια to an ontological conception of these terms. This should raise the question of what is not ontological about the former and what is ontological about the latter. To address these questions I discuss the commentaries by Heidegger and Menn, which alone come close to addressing these issues. But their readings cannot neatly distinguish between the two senses of δύναμις and ἐνέργεια (...) that we find in the Aristotelian text, thus compelling us to seek a better way of clarifying the standard interpretation, which I argue can be more precisely understood in the following way: δύναμις and ἐνέργεια in their customary meaning cannot be considered ontological in the sense that they have a particular locus among the categories, which is what sets them apart from their newer, ontological meaning. I conclude therefore that the text of Metaphysics IX can be understood as proceeding from an intracategorial conception of δύναμις and ἐνέργεια toward a transcategorial conception of these terms. (shrink)