Patients with chronic obstructive pulmonary disease are characterized by attenuated pulmonary function and are frequently reported with cognitive impairments, especially memory impairments. The mechanism underlying the memory impairments still remains unclear. We applied resting-state functional magnetic resonance imaging to compare the brain local activities with static and dynamic amplitude of low-frequency fluctuations among patients with COPD and healthy controls. Compared with HC, COPD patients exhibited decreased sALFF in the right basal ganglia and increased dALFF in the bilateral parahippocampal/hippocampal gyrus. The (...) reduced the left basal ganglia was associated with lower oxygen partial pressure. Besides, the increased dALFF in the left hippocampal/parahippocampal cortex was associated with poor semantic-memory performance and the increased dALFF in the left hippocampal/parahippocampal cortex was associated the forced vital capacity. The present study revealed the abnormal static and dynamic local-neural activities in the basal ganglia and parahippocampal/hippocampal cortex in COPD patient and its relationship with poor lung function and semantic-memory impairments. (shrink)

A pathogenic connection between autoreactive T cells, fungal infection, and carcinogenesis has been demonstrated in studies of human autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy as well as in a mouse model in which kinase-dead Ikkα knock-in mice develop impaired central tolerance, autoreactive T cell–mediated autoimmunity, chronic fungal infection, and esophageal squamous cell carcinoma, which recapitulates APECED. IκB kinase α is one subunit of the IKK complex required for NF-κB activation. IKK/NF-κB is essential for central tolerance establishment by regulating the development of medullary thymic (...) epithelial cells that facilitate the deletion of autoreactive T cells in the thymus. In this review, we extensively discuss the pathogenic roles of inborn errors in the IKK/NF-κB loci in the phenotypically related diseases APECED, immune deficiency syndrome, and severe combined immunodeficiency; differentiate how IKK/NF-κB components, through mTEC, T cells/leukocytes, or epithelial cells, contribute to the pathogenesis of infectious diseases, autoimmunity, and cancer; and highlight the medical significance of IKK/NF-κB in these diseases. IKK/NF-κB regulates the expression of many genes that encode proteins involved in many crucial biological functions, such as immunity, tissue homeostasis, and fungal/bacterial/viral infections. Also, IKKα plays anti-tumor activities in many organs independently of NF-κB pathways. Thus, an inborn error in one of these gene loci can cause severe human diseases through these complicated mechanisms. (shrink)

Previous studies have shown that changes in gray matter density and volume in the left primary motor cortex are significantly associated with changes in individuals’ verbal intelligence quotient, but not with their performance intelligence quotient. In the present study, we examined the effects of transcranial direct current stimulation over the left primary motor cortex on performance in intelligence tests. We chose four subtests of the Wechsler Adult Intelligence Scale-Chinese Revised version and randomized participants into anodal, cathodal, and sham groups. We (...) found that anodal stimulation significantly improved performance in verbal intelligence subtests compared to cathodal and sham stimulation, while performance intelligence subtest scores did not change in any stimulation condition. These findings suggest that the excitation level of the left primary motor cortex has a unique effect on verbal intelligence. (shrink)

Ist das Politische Macht? Ist es öffentliches Handeln oder die beste Gesellschaftsordnung? Daniela Hüttinger sucht dort nach einer Antwort, wo die historische Wurzel des Politischen vermutet wird: im Griechenland des 5. und 4.

本文是关于逻辑哲学相关专题的研究成果,包括逻辑本身的整体性的哲学思考、现代逻辑发展中的一些具体问题的哲学研究等。.

本书对弘扬中华民族美德的经典篇章进行挖掘整理、条分缕析,涵盖古今代表篇什,导读、原文、赏析三位一体,帮助读者在阅读中得到思想的启迪、道德的升华。.

Um das Recht auf sich selbst zu erringen, mussten die Menschen den GÖTTERN das Recht auf den Menschen nehmen. Seither verstanden sie sich immer weniger von den Pflichten einem HETERONOMEN Willen gegenüber als von ihren autonomen Rechten her, ihre Bedürfnisse zu befriedigen. Diesem Selbstverständnis des westlichen Menschen sind jedoch, will es nicht zur gefährlichen Selbstgerechtigkeit erstarren, Grenzen gesetzt. Denn das ästhetisch-materielle Glück, welches diesem zu Grunde liegt, ist weltweit weder sozialisierbar noch im Hinblick auf die Zukunft der Menschheit ökologisch vertretbar. (...) So müssen erneut die GÖTTER, ein HETERONOMER Wille, herhalten, um ein Selbstverständnis zu legitimieren, das sich der Negation eben dieses Willens verdankt und dessen Handlungsfolgen die Menschen nur allein zu verantworten haben. Benno Hübner, ehemals Professor an der Universität Zaragoza, schreibt, reist und diskutiert weiterhin mit Studenten aus dem lateinamerikanischen und russischen Sprachraum. (shrink)

本书作者以一名学者所特有的理想主义与批判主义精神,对法学研究和法制建设中的基本问题进行了探讨,并就法学基本内涵及其精神理念等提出了自己的见解。.

本卷收入胡适哲学与文化方面的论文、函牍、讲演、札记80余篇。其中包括实验主义、我们对于西洋近代文明的态度等重要文章。所收文章全面反映了胡适哲学思想、学术主张和对于中西文化的态度,对于了解和研究胡适本人 以及现代中国学术史、现代中国启蒙运动等内容。.

Academic journal publications may be retracted following institutional investigations that confirm allegations of research misconduct. Retraction notices can provide insight into the role institutional investigations play in the decision to retract a publication. Through a content analysis of 7,318 retraction notices published between 1927 and 2019 and indexed by the Web of Science, we found that most retraction notices (73.7%) provided no information about institutional investigations that may have led to retractions. A minority of the retraction notices (26.3%) mentioned an (...) institutional investigation either by journal authorities (12.1%), research performing organizations (10.3%), joint institutions (1.9%), research integrity and ethics governing bodies (1.0%), third-party institutions (0.5%), unspecified institutions (0.4%), or research funding organizations (0.1%). Comparing retraction notices issued before and after the introduction of retraction guidelines by the Committee on Publication Ethics (COPE) in 2009 revealed that those published after the guidelines’ publication were more likely to report investigations by journal authorities. Comparing retraction notices from different disciplines revealed that those from social sciences and the humanities were more likely to disclose investigations by research performing organizations than those from biomedical and natural sciences. Based on these findings, we suggest that the COPE retraction guidelines in the future make it mandatory to disclose in retraction notices institutional investigations leading to retractions. (shrink)

Experience marketing plays an important role in improving the quality and upgrading tourism services in cultural tourism cities and helps guide the planning and development, commodity design, and business management of cultural tourism products. However, the urgent problems that need to be solved are as follows: How does experiential marketing in cultural tourism cities affect tourists' consumption behavior? How to adjust consumption emotion in tourist experience and revisit intention? Starting from the experience needs of tourists, this study selected Jinan city, (...) represented by “Qilu culture,” as the research object; discussed the relationship between experiential marketing, consumption emotion, and revisit intention; and used a structural equation model to verify the relationship between the three. This study divided the perception of experiential marketing into four dimensions—sensory experience, action experience, emotional experience, and thinking experience, and divided tourists' revisit intention into two dimensions— “revisit” and “recommendation”. Totally, 305 tourists were randomly selected to participate in the questionnaire survey, and they came from 34 provinces in China. The results showed that cultural tourism cities can enhance tourists' positive consumption emotion through experiential marketing over time, and high-quality tourist consumption experience directly motivates tourists to revisit intention and then promotes tourists to go to cultural tourism cities for secondary consumption. These results suggest that cultural tourism cities should start from Maslow's hierarchy of needs theory, pay attention to the needs of tourists at different levels, and adopt effective experiential marketing strategies from tourism experience to improve the quality of tourists' travel experience and promote tourists' revisit intention. (shrink)

本书是以意识和意识形态为研究内容的专著,它既是意识发生学的说明,又是意识和意识形态结构学的认识论分析。.

This paper revisits Aristotle’s discussion of akrasia in NE VII. 1–10. I try to offer a scientific reading of the book, according to which NE VII. 1–10 closely instantiates the main guidelines of Aristotle’s Posterior Analytics. I propose that NE VII. 1–2, which aims to establish the fact that akrasia exists, corresponds to the ὅτι-stage of an Aristotelian scientific inquiry, and NE VII. 3–10, which aims to explain both the cause and the object of akrasia, corresponds to the διότι-stage of (...) the inquiry. (shrink)

Robots have been introduced into our society, but their social role is still unclear. A critical issue is whether the robot’s exhibition of intelligent behaviour leads to the users’ perception of the robot as being a social actor, similar to the way in which people treat computers and media as social actors. The first experiment mimicked Stanley Milgram’s obedience experiment, but on a robot. The participants were asked to administer electric shocks to a robot, and the results show that people (...) have fewer concerns about abusing robots than about abusing other people. We refined the methodology for the second experiment by intensifying the social dilemma of the users. The participants were asked to kill the robot. In this experiment, the intelligence of the robot and the gender of the participants were the independent variables, and the users’ destructive behaviour towards the robot the dependent variable. Several practical and methodological problems compromised the acquired data, but we can conclude that the robot’s intelligence had a significant influence on the users’ destructive behaviour. We discuss the encountered problems and suggest improvements. We also speculate on whether the users’ perception of the robot as being “sort of alive” may have influenced the participants’ abusive behaviour. (shrink)

On December 3 last year, Comrade Zhao Fusan of the Research Institute of Religion of the Chinese Academy of Social Sciences wrote a letter to Comrade Hu Qiaomu outlining his personal reflections on the Party Center's Document 19 [1982].

This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and (...) made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

Over recent years, the issue of corruption in the public construction sector has attracted increasing attention from both practitioners and researchers worldwide. However, limited efforts are available for investigating the underlying factors of corruption in this sector. Thus, this study attempted to bridge this knowledge gap by exploring the underlying factors of corruption in the public construction sector of China. To achieve this goal, a total of 14 structured interviews were first carried out, and a questionnaire survey was then administered (...) to 188 professionals in China. Two iterations of multivariate analysis approaches, namely, stepwise multiple regression analysis and partial least squares structural equation modeling were successively utilized to analyze the collected data. In addition, a case study was also conducted to triangulate the findings obtained from the statistical analysis. The results generated from these three research methods achieve the same conclusion: the most influential underlying factor leading to corruption was immorality, followed by opacity, unfairness, procedural violation, and contractual violation. This study has contributed to the body of knowledge by exploring the properties of corruption in the public construction sector. The findings from this study are also valuable to the construction authorities as they can assist in developing more effective anti-corruption strategies. (shrink)

Building on prior research in Confucianism and business, the current study examines the effects of Confucianism on consumer trust of government involvement with products and company brands. Based on three major ideas of Confucianism – meritocracy, loyalty to superior, and separation of responsibilities – it is expected that consumers under the influence of Confucianism would perceive products from government-involved enterprises to have more desirable attributes and show preference for their company brands. Findings from an empirical study in the Chinese automobile (...) market support the hypotheses. The results suggest that small firms doing business in China would especially benefit from some association with the government. These results also provide managerial implications for enterprises in other countries with a Confucian cultural background. (shrink)

Robots have been introduced into our society, but their social role is still unclear. A critical issue is whether the robot’s exhibition of intelligent behaviour leads to the users’ perception of the robot as being a social actor, similar to the way in which people treat computers and media as social actors. The first experiment mimicked Stanley Milgram’s obedience experiment, but on a robot. The participants were asked to administer electric shocks to a robot, and the results show that people (...) have fewer concerns about abusing robots than about abusing other people. We refined the methodology for the second experiment by intensifying the social dilemma of the users. The participants were asked to kill the robot. In this experiment, the intelligence of the robot and the gender of the participants were the independent variables, and the users’ destructive behaviour towards the robot the dependent variable. Several practical and methodological problems compromised the acquired data, but we can conclude that the robot’s intelligence had a significant influence on the users’ destructive behaviour. We discuss the encountered problems and suggest improvements. We also speculate on whether the users’ perception of the robot as being “sort of alive” may have influenced the participants’ abusive behaviour. (shrink)

People implicitly generalize the actions of known individuals in a social group to unknown members. However, actions have social goals and evaluative valences, and the extent to which actions with different valences (helpful and harmful) are implicitly generalized among group members remains unclear. We used computer animations to simulate social group actions, where helping and hindering actions were represented by aiding and obstructing another's climb up a hill. Study 1 found that helpful actions are implicitly expected to be shared among (...) members of the same group but not among members of different groups, but no such effect was found for harmful actions. This suggests that helpful actions are more likely than harmful actions to be implicitly generalized to group members. This finding was replicated in Study 2 by increasing the group size from three to five. Study 3 found that the null effect for generalizing harmful actions among group members is not due to the difficulty of detecting action generalization, as both helpful and harmful actions are similarly generalized within particular individuals. Moreover, Study 4 demonstrated that weakening social group information resulted in the absence of implicit generalization for helpful actions, suggesting the specificity of group membership. Study 5 revealed that the generalization of helping actions occurred when actions were performed by multiple group members rather than being repeated by one group member, showing group-based inductive generalization. Overall, these findings support valence-dependent implicit action generalization among group members. This implies that people may possess different knowledge regarding valenced actions on category-based generalization. (shrink)

本书从发展着的社会实践出发,不断吸取人类在认识过程中所获得的新的知识、经验和智慧,运用马克思主义哲学的方法探寻和思索社会、人生和人类思维的一些重大理论和实践问题。.

本书从新实在论、批判实在论、科学实在论三个流派方向,描述和分析了西方实在论哲学在20世纪中国的传播历程。.

本书包括:黑格尔与海德格尔论“无”;经验与存在;无限的存在与有限的存在;时间是存在的本质等内容。.

本书内容包括:上帝存在的证明、上帝的属性、奇迹和死后的生命、信仰意志和宗教经验等内容。.