Gene therapy has emerged from the idea of inserting a wild‐type copy of a gene in order to restore the proper expression and function of a damaged gene. Initial efforts have focused on finding the proper vector and delivery method to introduce a corrected gene to the affected tissue or cell type. Even though these first attempts are clearly promising, seveal problems remain unsolved. A major problem is the influence of chromatin structure on transgene expression. To overcome chromatin‐dependent repressive transgenic (...) states, researchers have begun to use chromatin regulatory elements to drive transgene expression. Insulators or chromatin boundaries are able to protect a transgene against chromatin position effects at their genomic integration sites, and they are able to maintain transgene expression for long periods of time. Therefore, these elements may be very useful tools in gene therapy applications for ensuring high‐level and stable expression of transgenes. BioEssays 26:796–807, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

The norm of assertion, to be in force, is a social norm. What is the content of our social norm of assertion? Various linguistic arguments purport to show that to assert is to represent oneself as knowing. But to represent oneself as knowing does not entail that assertion is governed by a knowledge norm. At best these linguistic arguments provide indirect support for a knowledge norm. Furthermore, there are alternative, non-normative explanations for the linguistic data (as in recent work from (...) Van Elswyk). Direct arguments would rely on normative judgments about the permissibility or impermissibility of assertions with and without the speaker knowing the content asserted. John Turri's work experimental results purport to show that our norm of assertion is factive, and probably knowledge. But as a number of recent experimentalists (Kneer, Reuter and Broessel, Marsili and Wiegmann) have shown, Turri's results rely on the problemmatic use of 'should' as in 'Maria should assert that she owns a 1990 watch.' Correcting for this, these experimentalists provide strong evidence that our norm of assertion is not factive. The standard reply to evidence like this from the assertion of unlucky falsehoods is the excuse maneuver. But Marsili and Wiegmann, following Turri's protocol for testing for excuse validation, show that participants who judge that assertions unlucky falsehoods are permissible are not guilty of excuse validation. Given our current understanding of the experimental evidence, knowledge is not our norm of assertion. (shrink)

This book is a unique contribution to the philosophy of religion. It offers a comprehensive discussion of one of the most famous arguments for the existence of God: the ontological argument. The author provides and analyses a critical taxonomy of those versions of the argument that have been advanced in recent philosophical literature, as well as of those historically important versions found in the work of St Anselm, Descartes, Leibniz, Hegel and others. A central thesis of the book is that (...) ontological arguments have no value in the debate between theists and atheists. There is a detailed review of the literature on the topic (separated from the main body of the text) and a very substantial bibliography, making this volume an indispensable resource for philosophers of religion and others interested in religious studies. (shrink)

Este trabajo se enmarca dentro del análisis de las acciones alternativas a la privación de libertad en adolescentes infractores a la ley penal. Intenta buscar soluciones que eviten la cárcel para quienes cometan pequeños delitos, opción que puede disminuir el índice de reincidencias. El objetivo es promover, desde el Trabajo Social, una doble reflexión: primero, analizando críticamente el concepto de delito, su definición en las diversas corrientes ideológicas y su aplicación en la legislación argentina; y segundo, la importancia de que (...) los jóvenes se responsabilicen de sus actos y experimenten caminos alternativos al delito.This work places inside the analysis of the alternative actions to the privation of freedom in inobservant teenagers to the penal law. It tries to look for solutions that avoid the jail for those who commit small crimes, option that can diminish the index of repetitions. The aim is to promote, from the Social Work, a double reflection: first, analyzing critically the concept of crime, his definition in the diverse ideological currents and his application in the argentine legislation; and second, the importance of which the young men take responsibility of his acts and experience alternative ways to the crime. (shrink)

The quest for real democracy is one of the components of sustainable degrowth. But the incipient debate on democracy and degrowth suffers from general definitions and limited connections to political philosophy and democracy theory. This article offers a critical review of democracy theory within the degrowth literature, taking as its focal point a relevant debate between Serge Latouche and Takis Fotopoulos. We argue that the core of their contention can be traced back to the relationship between the concepts of democracy (...) and autonomy as defined by philosopher Cornelius Castoriadis, which both authors and generally the degrowth movement consider as one of their theoretical reference points. We show how both Latouche and Fotopoulos hold a misconception of Castoriadis' notions of autonomy, the social imaginary and politics, which in turn limits their cognisance of democracy and hence confuses their debate concerning the possibilities for a degrowth transition within the confines of a liberal parliamentary democracy. With a clarified theoretical understanding of the interconnected democracy-autonomy assemble, we proceed to an evaluation of the revolutionary potential of the degrowth movement and to a better understanding of a possible relationship between democracy and degrowth. (shrink)

What is the biological function of perception? I hold perception, especially visual perception in humans, has the biological function of accurately representing the environment. Tyler Burge argues this cannot be so in Origins of Objectivity (Oxford, 2010), for accuracy is a semantical relationship and not, as such, a practical matter. Burge also provides a supporting example. I rebut the argument and the example. Accuracy is sometimes also a practical matter if accuracy partly explains how perception contributes to survival and reproduction.

Over the past three decades, economic sociology has been revealing how culture shapes economic life even while economic facts affect social relationships. This work has transformed the field into a flourishing and increasingly influential discipline. No one has played a greater role in this development than Viviana Zelizer, one of the world's leading sociologists. Economic Lives synthesizes and extends her most important work to date, demonstrating the full breadth and range of her field-defining contributions in a single volume for (...) the first time. Economic Lives shows how shared cultural understandings and interpersonal relations shape everyday economic activities. Far from being simple responses to narrow individual incentives and preferences, economic actions emerge, persist, and are transformed by our relations to others. Distilling three decades of research, the book offers a distinctive vision of economic activity that brings out the hidden meanings and social actions behind the supposedly impersonal worlds of production, consumption, and asset transfer. Economic Lives ranges broadly from life insurance marketing, corporate ethics, household budgets, and migrant remittances to caring labor, workplace romance, baby markets, and payments for sex. These examples demonstrate an alternative approach to explaining how we manage economic activity--as well as a different way of understanding why conventional economic theory has proved incapable of predicting or responding to recent economic crises. Providing an important perspective on the recent past and possible futures of a growing field, Economic Lives promises to be widely read and discussed. (shrink)

My paper proposes the concept of relational work to explain economic activity. In all economic action, I argue, people engage in the process of differentiating meaningful social relations. For each distinct category of social relations, people erect a boundary, mark the boundary by means of names and practices, establish a set of distinctive understandings that operate within that boundary, designate certain sorts of economic transactions as appropriate for the relation, bar other transactions as inappropriate, and adopt certain media for reckoning (...) and facilitating economic transactions within the relation. I call that process relational work. After identifying specific elements of a relational work approach, the paper focuses on the case of monetary differentiation. It compares a relational work theory of earmarking money with behavioral economics’ individually based mental accounting approach. (shrink)

La distinción sexo-género, introducida en la teorización feminista de los años setenta, habría puesto de manifiesto la pertinencia de distinguir entre el sexo y las representaciones socio-culturales e identitarias en las que aquel encontraría su despliegue. De la mano de Judith Butler, la teoría queer parece haber llevado esta distinción hasta el extremo, al sostener que existiría una discontinuidad radical entre los cuerpos sexuados y los géneros culturalmente construidos, y proponer una concepción performativa del género, que pondría de relieve el (...) papel central del sujeto en la configuración de su propia identidad. Sujeto que, sin embargo, ya no sería reconocido como mujer o como hombre, pues toda categoría referente a la distinción entre los sexos o entre los géneros binarios (masculino-femenino) habría sido cuestionada de forma radical. A partir de una aproximación a la distinción inicial sexo-género en el marco del debate feminista y de sus antecedentes, el objeto de este trabajo es indagar cómo se plantea esta distinción en una de las obras emblemáticas y pioneras de la filósofa norteamericana Judith Butler ―Gender Trouble―, a fin de abrir algunas líneas de discusión en torno a las aportaciones y limitaciones que habría traído consigo un discurso que nos confronta con la pregunta fundamental por la configuración de la identidad sexual y de género de la persona. (shrink)

The year 1992 is a year for reflection, because whether or not the quincentenary celebration of the arrival of the Europeans to this continent seems justified, one cannot escape thinking about the impact of this event on our land.As archeology is my area of study, my reflections are directed toward the changes that came about in the relationship between man and animals after 1492, specifically toward what occurred in Mexico once the Spaniards established themselves in this territory.

This is the first introductory textbook on non-classical propositional logics.

La llegada del covid-19 a Chile generó un gran cambio en la educación, se implementaron medidas estrictas de confinamiento la cual obligó a la educación presencial ir de manera virtual. La finalidad de este estudio es mostrar la percepción del estudiantado del programa Bachillerato en Ciencias de la Universidad Santo Tomás frente al proceso educativo virtual que se llevo a cabo en los años 2020-21. Se utilizó un cuestionario de tipo cualitativo, con 32 preguntas. Los resultados muestran que la educación (...) virtual en tiempos de pandemia, genero diversos factores de stress, problemas de conectividad, acceso a tecnologías y falta de aprendizaje. (shrink)

The author demonstrates the validity of the inference of particular sentences from universal sentences through the Aristotelian simple conversion and accidental conversion of categorical propositions.

In this book, Graham Oppy examines arguments for and against the existence of God. He shows that none of these arguments is powerful enough to change the minds of reasonable participants in debates on the question of the existence of God. His conclusion is supported by detailed analyses of the arguments as well as by the development of a theory about the purpose of arguments and the criteria that should be used in judging whether or not arguments are successful. (...) Oppy discusses the work of a wide array of philosophers, including Anselm, Aquinas, Descartes, Locke, Leibniz, Kant, Hume and, more recently, Plantinga, Dembski, White, Dawkins, Bergman, Gale and Pruss. (shrink)

Genocide in Rwanda, multiple murder at Denver or Dunblane, the gruesome activities of serial killers - what makes these great evils, and why do they occur? In addressing such questions this book, unusually, interconnects contemporary moral philosophy with recent work in New Testament scholarship. The conclusions to emerge are surprising. Gordon Graham argues that the inability of modernist thought to account satisfactorily for evil and its occurrence should not lead us to embrace an eclectic postmodernism, but to take seriously (...) some unfashionable pre-modern conceptions - Satan, demonic possession, spiritual powers, cosmic battles. Precisely because it strives to observe the high standards of clarity and rigour that are the hallmarks of philosophy in the analytical tradition, the book makes a powerful case for the rejection of humanism and naturalism, and for explaining the moral obligation to struggle against evil by reference to the New Testament's cosmic narrative. (shrink)

Each of the two major approaches to Aristotle--the unitarian, which understands his work as forming a single, unified system, and the developmentalist, which seeks a sequence of developing ideas--has inherent limitations. This book proposes a synthetic view of Aristotle that sees development as a change between systematic theories. Setting theories of the so-called logical works beside theories of the physical and metaphysical treatises, Graham shows that Aristotle's doctrines fall into two distinct systems of philosophies that are genetically related. This (...) study--the first major alternative to the unitarian approach since Jaeger pioneered the developmentalist method in 1923--provides a sweeping reappraisal of Aristotle's science and metaphysics and a new approach to the problem of substance presented in the Metaphysics. (shrink)

En esta breve reflexión nos centraremos en dos aspectos de la frase poética, el primero es el ritmo y el segundo, la metáfora. Nos referiremos al ritmo como imagen, musicalidad y sentido que trasciende la métrica, y a la metáfora como figura de pensamiento y vehículo para ingresar en una nueva percepción del mundo. El análisis de estos dos elementos propicia un acercamiento hermenéutico al poema como un devenir.

Changemaker Education is a collection of practitioner-based case studies that highlight the why, what, and how of empowering educational experiences.

The purpose of this article is to construct a critique of some works by the French artist Lucy Schwob, better known as Claude Cahun, who was active between 1910 and 1950. A writer and photographer, Cahun was at first very close to symbolist positions; later she was closer to the surrealist movement. Her work and her life, continually suspended between genders, and between ‘normality’ and ‘deviance’, have so far been analysed mainly through gender studies. This article attempts to restore the (...) inherent complexity of her poetic work and aesthetic. It tries to widen the field of study to deal with the representation of alterity, through reversing the stereotypical representation. (shrink)

Las nuevas prácticas pedagógicas buscan un camino donde el educador se encuentre con el educando de manera horizontal, debido a que el conocimiento no se limita a un aula. Por ello surge el término de educación expandida, que apoya la idea de que la educación trasciende y traspasa la escuela y empatiza con los nuevos escenarios tecnológicos de comunicación. El objetivo de la investigación consistió en diagnosticar y categorizar la educación expandida en tres casos de la Universidad UNIMINUTO, los cuales (...) tuvieron impacto en la transformación dentro de la interacción e intercambio de saberes de las practicas pedagógicas. (shrink)

This revised and considerably expanded 2nd edition brings together a wide range of topics, including modal, tense, conditional, intuitionist, many-valued, paraconsistent, relevant, and fuzzy logics. Part 1, on propositional logic, is the old Introduction, but contains much new material. Part 2 is entirely new, and covers quantification and identity for all the logics in Part 1. The material is unified by the underlying theme of world semantics. All of the topics are explained clearly using devices such as tableau proofs, and (...) their relation to current philosophical issues and debates are discussed. Students with a basic understanding of classical logic will find this book an invaluable introduction to an area that has become of central importance in both logic and philosophy. It will also interest people working in mathematics and computer science who wish to know about the area. (shrink)

The European framework surrounding clinical trials on medicinal products for human use is going to change as demonstrated by the large debate at European institutional level. One of the major challenges is to overcome the lack of harmonisation of clinical trial procedures among countries. This aspect is gaining more and more importance, considering the increasing number of multicentre and multinational studies. In this work, the actual European rules governing the Clinical Trial Application have been analysed throughout the different steps including (...) the registration of the trial in the European database; the preparation of documents to be submitted and their contents; the preparation of documents related to the information and consent process; the submission to competent bodies. Specific issues related to paediatric research and trials involving non EU/EEA countries have been addressed as well. Results reveal that the European legislation offers a well defined set of European rules covering different aspects of a Clinical Trial Application. However, these are not suitable to meet the challenges from multicentre and multinational clinical studies. A stronger set of rules, such as is available in a composite European Regulation has been adopted and is expected to harmonise practices and enable sponsors to carry out well conducted trials. But will the new regulation overcome the existing criticisms of Directive 2001/20/EC? (shrink)

This book is an exploration of philosophical questions about infinity. Graham Oppy examines how the infinite lurks everywhere, both in science and in our ordinary thoughts about the world. He also analyses the many puzzles and paradoxes that follow in the train of the infinite. Even simple notions, such as counting, adding and maximising present serious difficulties. Other topics examined include the nature of space and time, infinities in physical science, infinities in theories of probability and decision, the nature (...) of part/whole relations, mathematical theories of the infinite, and infinite regression and principles of sufficient reason. (shrink)

Based on Michel Foucault's 1978 and 1979 lectures at the Collège de France on governmental rationalities and his 1977 interview regarding his work on imprisonment, this volume is the long-awaited sequel to Power/Knowledge.

Las estrategias de adquisición léxica implementadas en formato multimedia han sido poco estudiadas, especialmente las que se utilizan en documentos diseñados para estudiantes en nivel preescolar. El objetivo de este artículo es identificar estrategias de adquisición léxica presentes en el documento digital que complementa al libro de texto de inglés para Kínder “Calibot 2”, único en su tipo de editorial chilena. Para esto, se llevó a cabo un estudio cualitativo de diseño análisis documental a la luz de la propuesta de (...) Nation (2007) conocida como las Four strands o cuatro hebras a partir de la que se levantaron categorías de análisis que fueron aplicadas por medio del software Nvivo12. Se encontraron 11 estrategias de adquisición léxica presentadas de forma multimedia que apoyarían la adquisición efectiva de léxico en una L2. Si bien los resultados aportan al ámbito pedagógico al promover el conocimiento de estrategias de adquisición léxica de L2 que pueden ser implementadas en formato multimedia, la presencia de estas estrategias se limita al documento analizado y sus resultados no pueden ser generalizados. (shrink)

This a general account of the school of Mo-tzu, its social basis as a movement of craftsmen, its isolated place in the Chinese tradition, and the nature of its later contributions to logic, ethics, and science. It assesses the relation of Mohist thinking to the structure of the Chinese language, and grapples with the textual dynamics of later Mohist writings, particularly in regard to grammar and style, technical terminology, the use and significance of stock examples, and overall organization. Includes edited (...) and annotated Chinese text with an English translation and commentary, a glossary, and a photographic reproduction of the unemended text from the Taoist Patrology. (shrink)

The goal of this research is to know and compare the emotions and reactions to confinement due to the COVID-19 pandemic in children and adolescents with high abilities and community samples. This is a mixed study with an exploratory reach that is descriptive, and which combines survey and qualitative methodologies to examine the emotions and reactions to confinement experiences of children and adolescents aged between 5 and 14 years. An online poll was designed with 46 questions, grouped into three sections: (...) General Data, Reactions to the health contingencies of COVID-19, and Positive and negative emotions. This last section was included the Oros’ positive emotions questionnaire and the scales of the negative effect of the PANAS Schedule positive and negative affect on children and adolescents between 8 and 14 years old. Data were collected online with a convenience sample. Quantitative data were analyzed with the SPSS statistics program and qualitative data with Alceste software. Among the main findings is the fact that there are no significant differences between the groups by ability in terms of reactions and emotions; however, there are differences between age groups and sex. The study discusses the implications for educational intervention in situations like the current pandemic. (shrink)

Este trabajo se propone examinar algunas características de la máscara del coquus en el corpus plautino. En primer término, se estudia el modo en que este personaje, a partir de las referencias al castigo físico y a la pasividad sexual, es construido como un cuerpo subordinado al servicio de otros. Luego, se consideran sus apariciones como ladrón y como proveedor de placeres corporales. Proponemos que la forma en que los cocineros son representados en la palliata de Plauto pone en evidencia (...) el vínculo que la axiología republicana establece entre actores sociales subalternos, corporalidad y amenaza a los mores maiorum. This paper examines some characteristics of the coquus mask in the plautine corpus. First, we study how this character, from references to physical punishment and sexual passivity, is built as a subordinate body to the service of others. Then, we consider his appearances as a thief and a provider of bodily pleasures. We propose that the way cooks are represented in Plautus' palliata shows us the link established by Republican axiology between subaltern social actors, body and threat to mores maiorum. (shrink)

Sebbene la ricchezza espressiva e la versatilità della scrittura di J.M. Coetzee si prestino ad una varietà di studi e considerazioni che riescono a coinvolgere molteplici discipline, solo i saggi che compongono il presente volume si impongono come un primo importante studio volto a comprendere, in maniera più sistematica, l’ampia pluralità di voci che caratterizza la critica coetziana. Il volume, dunque, riesce a superare le analisi meramente settoriali e unilaterali perché, cogliendo le pro...

How have human cultures engaged with and thought about animals, plants, rocks, clouds, and other elements in their natural surroundings? Do animals and other natural objects have a spirit or soul? What is their relationship to humans? In this new study, Graham Harvey explores current and past animistic beliefs and practices of Native Americans, Maori, Aboriginal Australians, and eco-pagans. He considers the varieties of animism found in these cultures as well as their shared desire to live respectfully within larger (...) natural communities. Drawing on his extensive casework, Harvey also considers the linguistic, performative, ecological, and activist implications of these different animisms. (shrink)

This paper argues for the general proper functionalist view that epistemic warrant consists in the normal functioning of the belief-forming process when the process has forming true beliefs reliably as an etiological function. Such a process is reliable in normal conditions when functioning normally. This paper applies this view to so-called testimony-based beliefs. It argues that when a hearer forms a comprehension-based belief that P (a belief based on taking another to have asserted that P) through the exercise of a (...) reliable competence to comprehend and filter assertive speech acts, then the hearer's belief is prima facie warranted. The paper discusses the psychology of comprehension, the function of assertion, and the evolution of filtering mechanisms, especially coherence checking. (shrink)

This two-part volume collects the complete fragments and most important testimonies for the leading presocratic philosophers. The Greek and Latin texts are translated on facing pages and accompanied by a brief commentary for each philosopher.

The _Physics_ is a foundational work of western philosophy, and the crucial one for understanding Aristotle's views on matter, form, essence, causation, movement, space, and time. This richly annotated, scrupulously accurate, and consistent translation makes it available to a contemporary English reader as no other does—in part because it fits together seamlessly with other closely associated works in the New Hackett Aristotle series, such as the _Metaphysics_, _De Anima_, and forthcoming _De Caelo_ and _On Coming to Be and Passing Away_. (...) Eventually the series will include all of Aristotle's works. Sequentially numbered endnotes provide the information most needed at each juncture, while a detailed Index of Terms indicates places where focused discussion of key notions occurs. An illuminating general Introduction describes the book that lies ahead, explaining what sort of work it is and what sorts of evidence it relies on. (shrink)

El objetivo de este estudio es evaluar la percepción de la inclusión educativa en sus dimensiones de políticas, prácticas y cultura de los directivos, docentes y asistentes de la educación, considerando las variables rol y género, en centros educativos de nivel secundario de la octava región del Biobío de Chile. La metodología es cuantitativa de carácter descriptivo, con un diseño no experimental transaccional, la muestra está compuesta de 346 profesionales. Los resultados generales arrojan una percepción muy favorable hacia la dimensión (...) prácticas inclusivas, tanto en la variable rol los directivos y en género las mujeres. (shrink)