Metagenomics bears upon all aspects of microbiology, including our understanding of mitochondrial and eukaryote origin. Recently, ribosomal protein phylogenies show the eukaryote host lineage – the archaeal lineage that acquired the mitochondrion – to branch within the archaea. Metagenomic studies are now uncovering new archaeal lineages that branch more closely to the host than any cultivated archaea do. But how do they grow? Carbon and energy metabolism as pieced together from metagenome assemblies of these new archaeal lineages, such as the (...) Deep Sea Archaeal Group (including Lokiarchaeota) and Bathyarchaeota, do not match the physiology of any cultivated microbes. Understanding how these new lineages live in their environment is important, and might hold clues about how mitochondria arose and how the eukaryotic lineage got started. Here we look at these exciting new metagenomic studies, what they say about archaeal physiology in modern environments, how they impact views on host‐mitochondrion physiological interactions at eukaryote origin. (shrink)

Verzeihen bedeutet Verzicht. Als ein zeitlicher Verzicht auf Tilgung von Schuld entzieht sich das Verzeihen dem Macht- und Möglichkeitsbereich normativ regulierbarer Handlungen und bildet die Grundlage für eine Ethik der Urteilsenthaltung. Verena Rauen weist in ihrer Studie das Verzeihen als Quellpunkt der ethischen Zeit aus. Das Verzeihen interveniert in den Schuldzusammenhang der kontinuierlichen Zeit der Geschichte und ermöglicht ethische, d.h. neue und nicht durch vorherige Schuld bestimmte Handlungen. Eine solche zeitliche Unterbrechung der Kausalverkettung der Schuld kann sich nur durch (...) einen Verzicht auf das moralische Urteil ereignen, der einen Wiederanfang in der Beziehung mit dem Anderen stets von neuem ermöglicht. So eröffnet das Verzeihen den ethischen Zeitraum des Zusammenlebens angesichts der nicht wiedergutzumachenden Schuld der Vergangenheit und der Ungewissheit der Zukunft - es bildet den konstitutiven Ursprung der Ethik. (shrink)

In this paper, I spell out a descriptive account of agnosticism that captures the intuitive view that a subject enters the mental state of agnosticism via an act or event called suspension. I will argue that agnosticism is a complex mental state, and that the formation of an attitude is the relevant act or event by which a subject commits to indecision regarding some matter. I will suggest a ‘two-component analysis’ that addresses two aspects that jointly account for the settled (...) state of agnosticism: the subject’s de facto indecision and the subject’s commitment to her indecision. Unlike meta-cognitivist or sui generis accounts, I do not take the agnostic’s commitment to indecision as constitutive for her indecision but rather as an evaluation or qualification of the indecision that she already exhibits. Agnosticism, thus, is a settled form of indecision that marks the end of inquiry. (shrink)

Frege spricht einerseits von der Zerlegung von Gedanken in Gedankenteile, andrerseits aber vom Aufbau von Gedanken. Scheinbar werden damit verschiedene inkompatible Auffassungen über Struktur bzw. Strukturlosigkeit von Gedanken ausgedrückt. Frege gebraucht jedoch den Ausdruck „Zerlegung" in mehreren Bedeutungen, die mit der Idee einer Konstruktion des Gedankens aus Teilen nicht nur vereinbar sind, sondern diese Idee sinnvoll ergänzen. Gedanken im Sinne Freges sind schon an sich auf eine bestimmte Weise logisch strukturiert und unterschieden sich gerade dadurch wesentlich von den sprachlichen Bedeutungen (...) natursprachlicher Sätze. (shrink)

X‐chromosome inactivation ensures dosage compensation between the sexes in mammals by randomly choosing one out of the two X chromosomes in females for inactivation. This process imposes a plethora of questions: How do cells count their X chromosome number and ensure that exactly one stays active? How do they randomly choose one of two identical X chromosomes for inactivation? And how do they stably maintain this state of monoallelic expression? Here, different regulatory concepts and their plausibility are evaluated in the (...) context of theoretical studies that have investigated threshold behavior, ultrasensitivity, and bistability through mathematical modeling. It is discussed how a twofold difference between a single and a double dose of X‐linked genes might be converted to an all‐or‐nothing response and how mutually exclusive expression can be initiated and maintained. Finally, candidate factors that might mediate the proposed regulatory principles are reviewed. (shrink)

This article addresses intraorganizational pressures for organizational transformation toward more responsible business practices by exploring the role of internal activists. Building on the interactive framing perspective, I ask how internal activists develop a framing of their company’s responsibilities as they attempt to transform its business practices from the inside out. I explore this question in the context of a Danish pharmaceutical company’s responsibilities regarding the rising diabetes problem. Grounded in an inductive, interpretive analysis, I show how internal activists developed a (...) framing of the company’s responsibility over time and eventually instigated new ways of thinking about and doing business in their organization. I theorize the constitutive processes that strengthened frame alignment and allowed the internal activists to shape business practices. My study contributes to the literature on corporate social responsibility (CSR) communication by explaining how intraorganizational processes of meaning making may constitute more responsible business practices and by explicating the distinct role of internal activists as agents of organizational transformation. (shrink)

In accordance with societal norms and values, consumers readily indicate their positive attitudes toward sustainability. However, they hardly take sustainability into account when engaging in exchange relationships with companies. To shed light on this paradox, this paper investigates whether defense mechanisms and the more specific concept of neutralization techniques can explain the discrepancy between societal norms and actual behavior. A multi-method qualitative research design provides rich insights into consumers’ underlying cognitive processes and how they make sense of their attitude–behavior divergences. (...) Drawing on the Ways Model of account-taking, which is advanced to a Cycle Model, the findings illustrate how neutralization strategies are used to legitimize inconsistencies between norm-conforming attitudes and actual behavior. Furthermore, the paper discusses how the repetitive reinforcement of neutralizing patterns and feedback loops between individuals and society are linked to the rise of anomic consumer behavior. (shrink)

The paper addresses the nature of seemings in light of their role in inquiry. Seemings are mental states or events with propositional content that have a specific phenomenology often referred to as “felt truth”. In epistemology, seemings are mainly discussed as possible (non-inferential) justifications for belief. Yet, epistemology has recently taken a zetetic turn, that is, a turn toward the study of inquiry. I will argue that the role of seemings in epistemology should be re-assessed from the perspective of inquiry (...) and deliberation. Seemings may fall short of justifying beliefs, but there is an important role for seemings in the zetetic realm, which may also explain why seemings lack direct justificatory force for beliefs. Seemings, so I will suggest, can provide normative reasons for performing certain zetetic tasks, but they cannot provide normative reasons for making up one’s mind about the inquired question. In this sense, the zetetic role of seemings can be described as guiding rational inquiry. I will suggest that a modified version of the so-called Taking Evidence View about the nature of seemings is best fitted to accommodate their zetetic role. Yet, contra existing versions of the Taking Evidence View, my modified account acknowledges that seemings are genuine experiences (of one’s evidential standing during inquiry) that are accompanied by the characteristic phenomenology of what is called a “feeling of truth”. By doing so, my modified version of the Taking Evidence View incorporates the (as I take it) most important feature of the rival Experience View of seemings. (shrink)

Name der Zeitschrift: Byzantinische Zeitschrift Jahrgang: 109 Heft: 2 Seiten: 769-784.

The significance of the complicated numbering of the propositions in the Tractatus has occasioned much speculation. Wittgenstein's own explanation has, following Stenius, been generally regarded as misleading. But an examination of the Prototractatus reveals that the numbering system was for Wittgenstein principally an aid in the composition of his work. It allowed him to mark out certain propositions which required further work or supplementation, without disturbing the basic structure of the treatise. But the reworking of the Prototractatus to form the (...) Tractatus considerably changed the original order in which the ideas were connected, and thus made it more difficult to understand the Tractatus. Several specific examples make it clear that it is essential to look back at the context of the Prototractatus in order to achieve a correct interpretation of many of the propositions in the Tractatus. (shrink)

While W.E.B. Du Bois’s first novel, The Quest of the Silver Fleece (1911), is set squarely in the USA, his second work of fiction, Dark Princess: A Romance (1928), abandons this national framework, depicting the treatment of African Americans in the USA as embedded into an international system of economic exploitation based on racial categories. Ultimately, the political visions offered in the novels differ starkly, but both employ a Western literary canon – so-called ‘classics’ from Greek, German, English, French, and (...) US American literature. With this, Du Bois attempts to create a new space for African Americans in the world (literature) of the 20th century. Weary of the traditions of this ‘world literature’, the novels complicate and begin to decenter the canon that they draw on. This reading traces what I interpret as subtle signs of frustration over the limits set by the literature that underlies Dark Princess, while its predecessor had been more optimistic in its appropriation of Eurocentric fiction for its propagandist aims. (shrink)

This article presents three brief case studies of the way Romans talked about and expressed contempt. It examines aspects of discourses about contempt that are characteristic both of Roman literature and of modern concepts. The focus is on the relationship of hierarchy, recognition, and (active and passive) contempt in the Latin vocabulary and in two literary motifs taken from invective and historiography, two genres in which expressions of contempt are particularly frequent and prominent.

Today's nurses find themselves in the position of having to redefine their identity. They must ask themselves why they matter, what is important about them as professionals, and how they contribute as team members. In this innovative and stimulating book, Verena Tschudin draws on her research and expertise to bring together aspects of nursing and ethics in a fresh and challenging way. Starting from the premise that 'people matter', she develops a basis for a nursing identity which gives a (...) new emphasis to individual and collective worth. Exploring the nature of nursing and the dilemmas facing today's professionals, she shares with students and colleagues her vision of nursing in the 21st century. This book will thus empower readers to discover fresh meaning in their work and role. (shrink)

Quine criticised the semantic notion of analyticity that is often attributed to Frege and Kant for presupposing an essentialist theory of meaning. In what follows I trace back the notion from Quine via Carnap to Frege and Kant, and eventually examine Kant's distinction between analytic and synthetic judgements in more detail. It turns out that the so called Frege-Kant-notion of analyticity can not be attributed to Kant. In contrast, Kant had a distinctly pragmatic notion of analytic judgements. According to him (...) analytic propositions elucidate certain presuppositions of our conceptual scheme, thereby serving the anti-metaphysical project of transcendental philosophy. (shrink)

In this paper, I will examine the notion of an epistemic dilemma, its characterizations in the literature, and the different intuitions prompted by it. I will illustrate that the notion of an epistemic dilemma is expected to capture various phenomena that are not easily unified with one concept: while some aspects of these phenomena are more about the agent in a certain situation, other aspects seem to be more about the situation as such. As a consequence, incompatible intuitions emerge concerning (...) the transparency of epistemic dilemmas as well as regarding the role that doxastic suspension plays in resolving cases of epistemic dilemma. I suggest to distinguish between the mental state of agents who find themselves in an epistemic dilemma and the normative situation that gives rise to a dilemma. I will refer to the agent’s mental state as epistemic conflict and will reserve the term epistemic dilemma for evidential situations in which epistemic principles either recommend incompatible doxastic responses or render all options impermissible. The concept of epistemic conflict not only captures the mental state of agents who find themselves in a genuine epistemic dilemma but also applies to agents who face difficult epistemic choices that they cannot resolve without substantial cognitive (and often pragmatic) effort, for example, via doxastic suspension. (shrink)

The term ‘ethics committees’ is used for very different things in different parts of the world. In Europe, ethics committees are generally concerned only with research and (apart from Belgium where the same committees deal with both aspects) do not have anything to do with decision making in clinical situations. This article traces the history of ethics committees in the UK and some of the problems encountered by them. It goes on to detail the situation in a number of other (...) European countries. Some topics of research touched on and published in articles in Nursing Ethics are then highlighted, thus making it clear that it is written from my perspective as the Editor of Nursing Ethics and with the help of some of the members of the Editorial Board. Finally, a number of questions are asked and answers attempted concerning the interests served by ethics committees. (shrink)

Ecopolitics is a study of environmental awareness--or non-awareness--in contemporary French theory. Arguing that it is now impossible not to think in an ecological way, Verena Andermatt Conley traces the roots of today's concern for the environment back to the intellectual climate of the late '50s and '60s. Major thinkers of 1968, the author argues, changed the way we think the world; this owes much to an ecological awareness that remains at the heart of issues concerning cultural theory in general. (...) The book points to critiques of ecology in the work of Luc Ferry and Jean Baudrillard before turning to more complicated ecological awareness primarily in French thought. The author considers key texts by influential figures such as Michael Serres, Paul Virilio, Gilles Deleuze and Felix Guattari, Michel de Certeau, Helene Cixous and Luce Irigaray. (shrink)

Age attitudes and age stereotypes in the workplace can lead to discrimination and impaired productivity. Previous studies have predominantly assessed age stereotypes with explicit measures. However, sole explicit measurement is insufficient because of social desirability and potential inaccessibility of stereotypical age evaluations to introspection. We aimed to advance the implicit and explicit assessment of work-related evaluations of age groups and age stereotypes and report data collected in three samples: students (n = 50), older adults (n = 53), and workers (n (...) = 93). Evaluative age attitudes were measured implicitly with an Implicit Association Test. Regardless of group, age, and condition (neutral or semantically biased stimuli), the results confirm a stable, moderate implicitly measurable preference for younger over older workers. Whereas explicit measures of general age preferences showed no clear age preference, differentiated explicit measures of work-related age stereotypes also revealed stable preferences in all three samples: Younger workers were rated higher on performance and adaptability and older workers were rated higher on competence, reliability, and warmth. The explicit-implicit correlations were relatively low. Although explicit work-related age stereotypes are differentiated, the stable implicitly measured age bias raises concern. We suggest to apply implicit and explicit measures in the field of ageism in the workplace. (shrink)

Smart Cities consist of a multitude of interconnected devices and services to, among others, enhance efficiency, comfort, and safety. To achieve these aims, smart cities rely on an interplay of measures including the deployment of interventions targeted to foster certain human behaviors, such as saving energy, or collecting and exchanging sensor and user data. Both aspects have ethical implications, e.g., when it comes to intervention design or the handling of privacy-related data such as personal information, user preferences or geolocations. Resulting (...) concerns must be taken seriously, as they reduce user acceptance and can even lead to the abolition of otherwise promising Smart City projects. Established guidelines for ethical research and practice from the psychological sciences provide a useful framework for the kinds of ethical issues raised when designing human-centered interventions or dealing with user-generated data. This article thus reviews relevant psychological guidelines and discusses their applicability to the Smart City context. A special focus is on the guidelines’ implications and resulting challenges for certain Smart City applications. Additionally, potential gaps in current guidelines and the limits of applicability are reflected upon. (shrink)

When studying the feasibility and justice of basic income, researchers usually assume that policymakers would be introducing the unconditional benefit to a closed economic entity. When contemplating the introduction of a universal policy, few researchers take into consideration the fact that citizens and foreigners migrate, and that this movement alters the size and skill structure of the population. This article addresses this oversight by analyzing how basic income schemes based on residence or citizenship may affect tax base, wages, and employment (...) while incorporating migration incentives. The discussion is based upon neoclassical labor supply and migration theory and informed by the conjectured economic effects from a normative perspective. This research suggests that a basic income would create migration incentives that reduce the tax base, leading us to question this policy’s feasibility. Moreover, the flow-on effects of migration call into question the justice of both residence-based and citizenship-based basic income schemes. Therefore, this article sheds light on how basic income’s feasibility and justice relate to each other and identifies the benefits and further opportunities for interdisciplinary social policy research. (shrink)

In diesem Sammelband werden Aufsätze von renommierten Husserl-Forschern und Nachwuchswissenschaftlern zu systematischen Fragen und Problemen von Husserls Phänomenologie versammelt. Die Texte basieren teilweise auf Vorträgen der Tagung „Die Aktualität Husserls", die 2009 an der LMU München stattgefunden hat. In drei thematischen Blöcken, die sich schwerpunktmäßig auf Probleme der Ontologie, Sprachphilosophie/ Philosophie des Geistes und Handlungstheorie/Ethik konzentrieren, wird die systematische Breite und Komplexität von Husserls Denken deutlich, das sich nahezu nahtlos auf aktuelle Fragestellungen beziehen lässt - wenngleich es sich diesen nicht (...) immer anpasst und in kritischer Distanz insbesondere zur Naturalisierbarkeit des Geistes bleibt. Mit Beiträgen von Emanuele Caminada, Christian Beyer, Christopher Erhard, Sophie Loidolt, Verena Mayer, Uwe Meixner, Roberta De Monticelli, Henning Peucker, Sonja Rinofner-Kreidl, Rochus Sowa und Thomas Vongehr. (shrink)

By analysing the first, second, 10th and 11th years of publication (i.e. volumes 1, 2, 10, 11) of Nursing Ethics, I will show the significant visible trends in the articles and draw some conclusions. The trends are visible at various levels: from simple analysis of an issue, or a comment on a situation in the early years, to in-depth philosophical and research studies; and from short statements to much longer articles. The ethical approaches used go from either none or unquestioned (...) assumptions to several approaches used in any one study. This corresponds to the general postmodern trend in society. The interpretation made of these trends is of a kind of protest at nurses and nursing being devalued. Although this is expressed negatively, the positive message conveyed is that nurses are now taking their professional life into their own hands, vigorously and more daringly than a decade ago. (shrink)

1 Das Paradox des Regelfolgens Regeln im Sinne von Handlungsvorschriften setzen ihre Anwendbarkeit schon begrifflich voraus. Alle Regeln regeln mögliches Verhalten, seien es Verkehrsregeln, juridische Gesetze, mathematische und logische Verfahren, und selbst „Bedeutungs-postulate“, die festlegen, wie ein Ausdruck verständlich zu verwenden ist. Regeln ohne irgendeinen möglichen Anwendungsspielraum sind sinnlos. Dabei werden durch Regeln nicht nur mögliche Anwendungen präsupponiert, sondern umgekehrt aus gegebenen Tatsachen oder Ereignissen Regelmäßigkeiten herausgelesen, die sich in der Regel ausdrücken. Die Regel bezeichnet in diesem Sinne das „Prinzip (...) hinter den Tatsachen“, das sie diesen freilich in gewisser Weise erst andichtet. Zweck dieses Vorgehens ist nicht zuletzt, die mögliche Fortsetzung der Tatsachenreihe gleichzeitig zu bestimmen und zu begründen, jedenfalls aber eine gewisse Ordnung, Rechtfertigung und Voraussagbarkeit des Handelns zu gewährleisten. Regelanwendung verlangt deshalb eine komplexe geistige Kompetenz, die nicht nur Fähigkeiten der Abstraktion und Reflexion, sondern auch Können und Erfahrung voraussetzt. (shrink)

Modern nursing evolved out of a war. Today’s nurses not only work in war zones but the profession as a whole needs to consider its responsibility in caring for victims of conflict and what its international duty is in preventing wars. This means that nurses must be informed of the devastation caused by conflict not only in countries where conflicts and war take place but also world-wide. Nurses’ responsibility is to prevent illness and alleviate suffering, which includes the long-term morbidity (...) caused by wars. They need to be more politically active in conflict resolution and prevention at local, community, national and international levels. The purpose of this article is to address these issues from an ethical perspective and to suggest implications for nursing education and practice. (shrink)

,is article addresses the relationship between sovereignty, biopolitics and governmentality in the work of Giorgio Agamben, Judith Butler, and Michel Foucault. By unpacking Foucault’s genealogy of modern governmentality, it responds to a criticism leveled against Foucauldian accounts of power for their alleged abandonment of the traditional model of power in juridico-institutional terms in favor of an understanding of power as purely productive. ,is claim has most signi-cantly been developed by Agamben in “Homo Sacer: Sovereign Power and Bare Life”. I argue (...) that Judith Butler’s analysis of power, in particular in her essay “Inde-nite Detention”, presents a more di.erentiated account of power that registers the signi-cance of practices of sovereignty and resonates with Foucault’s lectures on “Security, Territory, Population”. (shrink)

Die hier versammelten Beiträge analysieren Typen und Funktionen der Ambiguität an Beispielen aus der mittelalterlichen bis zur zeitgenössischen Kunst.

Vaccine hesitancy persists despite vaccination’s important role in global health. As many vaccines provide social benefits through herd immunity, vaccination decisions can raise moral concerns. Two studies explored the role of moral convictions in vaccination decisions. Study 1 (N = 485) revealed higher vaccination intentions when individuals thought about vaccination in moral terms. Emotions and moral piggybacking positively predicted moral convictions. In Study 2 (N = 1,111), we evaluated the effects of emotional, moral, and scientific pro-vaccination arguments on moral convictions, (...) support for mandatory vaccination, and tolerance of dissenting views. While no group differences were observed, moral convictions were correlated with increased support for mandatory vaccination but also with a reduced tolerance of dissenting opinions. Overall, moral convictions play a small but significant role in vaccination-related decisions. While moral convictions have beneficial effects on compliance, it is crucial not to overlook the adverse consequences, which may lead to a growing societal divide. (shrink)

Compatibilist methods borrowed from the free will debate are often used to establish doxastic freedom and epistemic responsibility. Certain analogies between the formation of intention and belief make this approach especially promising. Despite being a compatibilist myself in the practical debate, I will argue that compatibilist methods fail to establish doxastic freedom. My rejection is not based on an argument against the analogy of free will and free belief. Rather, I aim at showing that compatibilist free will and free belief (...) are equally misguided because freedom is a concept that only applies to an agent’s actions and not to her mental attitudes. Compatibilist strategies that seek to define control by reason-responsiveness merely weaken the conditions for freedom such that arbitrary forms of control can be defined. I will demonstrate that these methods also commit to freedom of fear, freedom of hope and freedom of anger. However, I accept the compatibilist challenge to account for the addict’s and the paranoid’s unfreedom. I will sketch a unified approach to compatibilist free agency that does justice to these phenomena without the help of free will or free belief. (shrink)