This article is a response to a paper presented to the New Zealand Historical Association in 1991 by J. G. A. Pocock, who suggests that Pakeha (European) settlers are now becoming tangata whenua (people of the land) in the same way that Maori did. The principal idea examined is what an `indigenous' identity means once historical claims have been settled by Maori against the Crown, and whether there is any merit in the term `indigenous'. The article then examines the logic (...) behind the idea of `original occupation' and the assumed rights associated with this concept. (shrink)

Polarization is pervasive in the current sociopolitical discourse. Polarization tends to increase cognitive inflexibility where people become less capable of updating their beliefs upon new information or switching between different ways of thinking. Cognitive inflexibility can in turn increase polarization. We propose that this positive feedback loop between polarization and cognitive inflexibility is a form of threat response that has benefited humans throughout their evolutionary history. This feedback loop, which can be driven by conflict mindset, group conformity, and simplification of (...) information, facilitates the formation of strong bonds within a group that are able to eliminate threats and increase individual fitness. Although cognitive inflexibility is conventionally seen as maladaptive, here we argue that cognitive inflexibility may be an adaptation under polarization. That is, in a highly polarized society most people only interact with members of their own social group, without having to confront perspectives from another group or interacting with out-group members. In this context, cognitive inflexibility creates rigid cognitive specialization, a set of cognitive traits that allow people to operate efficiently within their social circles but not outside of it. Although rigid cognitive specialization benefits individuals in the short term, it may lead to more polarization over the long run, and thus produce more conflict between groups. We call on future research to examine the link between cognitive inflexibility and rigid cognitive specialization. (shrink)

The modern way of life is highly dependent upon the production of goods by industrial organizations that are in turn dependent upon their workers for their ongoing operations. Even though more than a century has passed since the dawn of the industrial revolution, many dangerous aspects of work, both physical and mental, remain in the workplace today. Using Buddhist philosophical principles, this paper suggests that although many sources of the problem reside within the larger society, the industrial engineer is still (...) a key factor in bettering work and providing a workplace suitable for their fellow workers. Drawing on these insights, we present a number of work design guidelines that industrial engineers who abide by Buddhist principles could practice to help overcome some of the many sufferings produced by modern work. (shrink)

The etiology of Tauopathies, a diverse class of neurodegenerative diseases associated with the Microtubule Associated Protein (MAP) Tau, is usually described by a common mechanism in which Tau dysfunction results in the loss of axonal microtubule stability. Here, we reexamine and build upon the canonical disease model to encompass other Tau functions. In addition to regulating microtubule dynamics, Tau acts as a modulator of motor proteins, a signaling hub, and a scaffolding protein. This diverse array of functions is related to (...) the dynamic nature of Tau isoform expression, post‐translational modification (PTM), and conformational flexibility. Thus, there is no single mechanism that can describe Tau dysfunction. The effects of specific pathogenic mutations or aberrant PTMs need to be examined on all of the various functions of Tau in order to understand the unique etiology of each disease state. (shrink)

Pathogenesis in tauopathies involves the accumulation of tau in the brain and progressive synapse loss accompanied by cognitive decline. Pathological tau is found at synapses, and it promotes synaptic dysfunction and memory deficits. The specific role of toxic tau in disrupting the molecular networks that regulate synaptic strength has been elusive. A novel mechanistic link between tau toxicity and synaptic plasticity involves the acetylation of two lysines on tau, K274, and K281, which are associated with dementia in Alzheimer's disease (AD). (...) We propose that an increase in tau acetylated on these lysines blocks the expression of long‐term potentiation at hippocampal synapses leading to impaired memory in AD. Acetylated tau could inhibit the activity‐dependent recruitment of postsynaptic AMPA‐type glutamate receptors required for plasticity by interfering with the postsynaptic localization of KIBRA, a memory‐associated protein. Strategies that reduce the acetylation of tau may lead to effective treatments for cognitive decline in AD. (shrink)

This highly original, provocative, and poetic work explores the nexus of time, truth, and death in the symbolic world of medieval kabbalah. Demonstrating that the historical and theoretical relationship between kabbalah and western philosophy is far more intimate and extensive than any previous scholar has ever suggested, Elliot R. Wolfson draws an extraordinary range of thinkers such as Frederic Jameson, Martin Heidegger, Franz Rosenzweig, William Blake, Julia Kristeva, Friedrich Schelling, and a host of kabbalistic figures into deep conversation with one (...) another. _Alef, Mem, Tau _also discusses Islamic mysticism and Buddhist thought in relation to the Jewish esoteric tradition as it opens the possibility of a temporal triumph of temporality and the conquering of time through time. The framework for Wolfson’s examination is the rabbinic teaching that the word _emet, _“truth,” comprises the first, middle, and last letters of the Hebrew alphabet, _alef, mem,_ and _tau,_ which serve, in turn, as semiotic signposts for the three tenses of time—past, present, and future. By heeding the letters of _emet _we discern the truth of time manifestly concealed in the time of truth, the beginning that cannot begin if it is to be the beginning, the middle that re/marks the place of origin and destiny, and the end that is the figuration of the impossible disclosing the impossibility of figuration, the finitude of death that facilitates the possibility of rebirth. The time of death does not mark the death of time, but time immortal, the moment of truth that bestows on the truth of the moment an endless beginning of a beginningless end, the truth of death encountered incessantly in retracing steps of time yet to be taken—between, before, beyond. (shrink)

Bringing about desirable collisions (making interceptions) and avoiding unwanted collisions are critically important sensorimotor skills, which appear to require us to estimate the time remaining before collision occurs (time-to-collision). Until recently the theoretical approach to understanding time-to-collision estimation has been dominated by the tau-hypothesis, which has its origins in J.J. Gibson’s ecological approach to perception. The hypothesis proposes that a quantity (tau), present in the visual stimulus, provides the necessary time-to-collision information. Empirical results and formal analyses have now accumulated to (...) demonstrate conclusively that the tau-hypothesis is false. This article describes an alternative approach that is based on recent data showing that the information used in judging time-to-collision is task- and situation-dependent, is of many different origins (of which tau is just one) and is influenced by the information-processing constraints of the nervous system. (shrink)

Parkinson's disease (PD) is generally sporadic but a number of genetic diseases have parkinsonism as a clinical feature. Two dominant genes, α‐synuclein (SNCA) and leucine‐rich repeat kinase 2 (LRRK2), are important for understanding inherited and sporadic PD. SNCA is a major component of pathologic inclusions termed Lewy bodies found in PD. LRRK2 is found in a significant proportion of PD cases. These two proteins may be linked as most LRRK2 PD cases have SNCA‐positive Lewy bodies. Mutations in both proteins are (...) associated with toxic effects in model systems although mechanisms are unclear. LRRK2 is an intracellular signaling protein possessing both GTPase and kinase activities that may contribute to pathogenicity. A third protein, tau, is implicated as a risk factor for PD. We discuss the potential relationship between these genes and suggest a model for PD pathogenesis where LRRK2 is upstream of pathogenic effects through SNCA, tau, or both proteins. (shrink)

Machine-generated contents note: Unlearn me, please! (a commissioned poem by Lucy Jarasius) -- Art-making -- Arts, Artists and Art-making -- Art-making as a Way of Knowing -- Identification of Art-making as a Way of Knowing -- FP-I and Art-making as a Way of Knowing -- A Participatory Link: Presentational Knowing -- Art-making and Spirituality -- Raranga (Maori Weaving) -- Graphic and Digital Design -- Dance-making -- Art-making and Spirituality in my Study -- Art-making and Creative Process -- An Interwoven Way (...) of Knowing -- Training and Practice in Art-making -- Examples of Art-Making --Dance -- Choreographed performance -- Improvisation -- Dance-making Preparation -- Performance and Audience -- Creative Processes -- Changing Attitudes -- Changes from One Performance to Another -- Dance-making in My Study -- Raranga (Maori Weaving) -- Dance-making and Raranga as Ways of Knowing -- Examples of Other Art-making Areas -- Acting -- Fiction-writing -- Graphic and Digital Design -- Music-making -- Photography -- Poetry -- Poetry as a Way of Knowing: Lucy's Experience (Lucy Jarasius 2015) -- Dance and Poetry as Ways of Knowing: My Experience.Machine-generated contents note: Unlearn me, please! (a commissioned poem by Lucy Jarasius) -- Art-making -- Arts, Artists and Art-making -- Art-making as a Way of Knowing -- Identification of Art-making as a Way of Knowing -- FP-I and Art-making as a Way of Knowing -- A Participatory Link: Presentational Knowing -- Art-making and Spirituality -- Raranga (Maori Weaving) -- Graphic and Digital Design -- Dance-making -- Art-making and Spirituality in my Study -- Art-making and Creative Process -- An Interwoven Way of Knowing -- Training and Practice in Art-making -- Examples of Art-Making --Dance -- Choreographed performance -- Improvisation -- Dance-making Preparation -- Performance and Audience -- Creative Processes -- Changing Attitudes -- Changes from One Performance to Another -- Dance-making in My Study -- Raranga (Maori Weaving) -- Dance-making and Raranga as Ways of Knowing -- Examples of Other Art-making Areas -- Acting -- Fiction-writing -- Graphic and Digital Design -- Music-making -- Photography -- Poetry -- Poetry as a Way of Knowing: Lucy's Experience (Lucy Jarasius 2015) -- Dance and Poetry as Ways of Knowing: My Experience. (shrink)

Fibrillar protein aggregates are the pathological hallmark of a group of age‐dependent neurodegenerative conditions, including Alzheimer's and Parkinson's disease. Aggregates of the microtubule‐associated protein Tau are observed in Alzheimer's disease and primary tauopathies. Tau pathology propagates from cell to cell in a prion‐like process that is likely subject to modulation by extracellular chaperones such as Clusterin. We recently reported that Clusterin delayed Tau fibril formation but enhanced the activity of Tau oligomers to seed aggregation of endogenous Tau in a cellular (...) model. In contrast, Clusterin inhibited the propagation of α‐Synuclein aggregates associated with Parkinson's disease. These findings raise the possibility of a mechanistic link between Clusterin upregulation observed in Alzheimer's disease and the progression of Tau pathology. Here we review the diverse functions of Clusterin in the pathogenesis of neurodegenerative diseases, focusing on evidence that Clusterin may act either as a suppressor or enhancer of pathology. (shrink)

Background: Depression is the largest cause of mental ill health worldwide. Although interventions such as Dance Movement Therapy (DMT) may offer interesting and acceptable treatment options, current clinical guidelines do not include these interventions in their recommendations mainly because of what is perceived as insufficient research evidence. The 2015 Cochrane review on DMT for depression includes only three RCTs leading to inconclusive results. It is therefore, necessary to also look beyond such designs in order to identify and assess the range (...) of current evidence. Methods: We therefore, conducted a systematic review of studies that aimed to explore the effectiveness in the use of DMT with people with depression. This led to a qualitative narrative synthesis followed by a subgroup analysis and a sensitivity analysis. In all meta-analyses a random effects model was used with Standardised Mean Differences (SMD) to accommodate for the heterogeneity of studies and outcome measures. Results: From the 817 studies reviewed, eight studies met our inclusion criteria. 351 people with depression (mild to severe) participated, 192 of whom attended DMT groups while receiving treatment as usual (TAU) and 159 received TAU only. Qualitative findings suggest there was a decrease in depression scores in favour of DMT groups in all studies. Subgroup analysis performed on depression scores before and three months after the completion of DMT groups suggested changes in favour of the DMT groups. When sensitivity analysis was performed, RCTs at high risk of bias were excluded, leaving only studies with adult clients up to the age of 65. In these studies, the highest effect size was found favouring DMT plus TAU for adults with depression, when compared to TAU only. Conclusions: Based on studies with moderate to high quality, we concluded that DMT is an effective intervention in the treatment of depression with adults. Furthermore, by drawing on a wide range of designs with diverse quality, we were able to compile a comprehensive picture of relevant trends. Despite the fact that there remains a paucity of high-quality studies, the results have relevance to both policy-making and clinical practice, and become a platform for further research. (shrink)

Intensive research is carried out to develop a disease-modifying drug for Alzheimer’s disease. The development of drug candidates that reduce Aß or tau in the brain seems particularly promising. However, these drugs target people at risk for AD, who must be identified before they have any, or only moderate, symptoms associated with the disease. There are different strategies that may be used to identify these individuals. Each of these strategies raises different ethical challenges. In this paper, we analyse these challenges (...) in relation to the risk stratification for AD necessary for using these drugs. We conclude that the new drugs must generate large health benefits for people at risk of developing AD to justify the ethical costs associated with current risk stratification methods, benefits much larger than current drug candidates have. This conclusion raises a new set of ethical questions that should be further discussed. No data are available. (shrink)

IntroductionConcussion is a growing public health concern. No uniformly established therapy exists; neurofeedback studies report treatment value. We use infralow frequency neuromodulation to remediate disabling neurological symptoms caused by traumatic brain injury and noted improved outcomes with a novel concussion protocol. Postconcussion symptoms and persistent postconcussion symptoms are designated timelines for protracted neurological complaints following TBI. We performed a retrospective study to explore effectiveness of ILF in PCS/PPCS and investigated the value of using this concussion protocol.MethodPatients with PCS/PPCS seen for (...) their first neurology office visit or received their first neurofeedback session between 1 August 2018 and 31 January 2021 were entered. Outcomes were compared following treatment as usual vs. TAU with ILF neurotherapy. The study cohort was limited to PPCS patients; the TAU+ILF group was restricted further to PPCS patients receiving at least 10 neurotherapy sessions. Within the TAU+ILF group, comparisons were made between those who trained at least 10 sessions using concussion protocol and those who trained for at least 10 sessions of ILF regardless of protocol.ResultsAmong our resultant PPCS cohort leading persistent neurological complaints were headache, memory impairment, and brain fog. PPCS patients in TAU+ILF+CP demonstrated greater net and percent improvement of symptoms compared to PPCS subjects in TAU. PPCS patients in TAU+ILF-CP trended toward significant symptom improvements compared to TAU, and TAU+ILF+CP trended toward greater efficacy than TAU+ILF-CP.ConclusionPPCS patients who received TAU+ILF+CP demonstrated significantly greater improvement as a group when compared to TAU. When used as an integrative modality to treatment as usual in managing patients with PPCS, ILF neuromodulation with use of concussion protocol provided significant symptom improvements. (shrink)

In this article, monist values are expressed as preferences like in economics and decision making. On the basis of this formalization, various ways of defining value disagreement of agents within a group are investigated. Twelve notions of categorical value disagreement are laid out. Since these are too coarse-grained for many purposes, known distance-based approaches like Kendall’s Tau and Spearman’s footrule are generalized from linear orders to preorders and position-sensitive variants are developed. The account is further generalized to allow for agents (...) with incomplete information. The article ends with a discussion of known limitations of preference-based accounts of values and how these might be overcome by accounting for parity and essential incompleteness. It is also shown that one intuitively compelling notion of disagreement does not give rise to a proper distance measure. (shrink)

What is an inference rule? This question does not have a unique answer. One usually finds two distinct standard answers in the literature; validity inference $(\sigma \vdash_\mathrm{v} \varphi$ if for every substitution $\tau$, the validity of $\tau \lbrack\sigma\rbrack$ entails the validity of $\tau\lbrack\varphi\rbrack)$, and truth inference $(\sigma \vdash_\mathrm{t} \varphi$ if for every substitution $\tau$, the truth of $\tau\lbrack\sigma\rbrack$ entails the truth of $\tau\lbrack\varphi\rbrack)$. In this paper we introduce a general semantic framework that allows us to investigate the notion of inference (...) more carefully. Validity inference and truth inference are in some sense the extremal points in our framework. We investigate the relationship between various types of inference in our general framework, and consider the complexity of deciding if an inference rule is sound, in the context of a number of logics of interest: classical propositional logic, a nonstandard propositional logic, various propositional modal logics, and first-order logic. (shrink)

Intuitionistic propositional logic with Galois negations ( \(\mathsf {IGN}\) ) is introduced. Heyting algebras with Galois negations are obtained from Heyting algebras by adding the Galois pair \((\lnot,{\sim })\) and dual Galois pair \((\dot{\lnot },\dot{\sim })\) of negations. Discrete duality between GN-frames and algebras as well as the relational semantics for \(\mathsf {IGN}\) are developed. A Hilbert-style axiomatic system \(\mathsf {HN}\) is given for \(\mathsf {IGN}\), and Galois negation logics are defined as extensions of \(\mathsf {IGN}\). We give the bi-tense (...) logic \(\mathsf {S4N}_t\) which is obtained from the minimal tense extension of the modal logic \(\mathsf {S4}\) by adding tense operators. We give a new extended Gödel translation \(\tau \) and prove that \(\mathsf {IGN}\) is embedded into \(\mathsf {S4N}_t\) by \(\tau \). Moreover, every Kripke-complete Galois negation logic _L_ is embedded into its tense companion \(\tau (L)\). (shrink)

Content Description #"Under the auspices of the Wisconsin-Alpha Chapter of Phi Sigma Tau."#Includes bibliographical references.

We show that the Turing degrees are not sufficient to measure the complexity of continuous functions on [0, 1]. Computability of continuous real functions is a standard notion from computable analysis. However, no satisfactory theory of degrees of continuous functions exists. We introduce the continuous degrees and prove that they are a proper extension of the Turing degrees and a proper substructure of the enumeration degrees. Call continuous degrees which are not Turing degrees non-total. Several fundamental results are proved: a (...) continuous function with non-total degree has no least degree representation, settling a question asked by Pour-El and Lempp; every non-computable f $\epsilon \mathcal{C}[0, 1]$ computes a non-computable subset of $\mathbb{N}$ ; there is a non-total degree between Turing degrees $a _\eqslantless_{\tau}$ b iff b is a PA degree relative to a; $\mathcal{S} \subseteq 2^{\mathbb{N}}$ is a Scott set iff it is the collection of f-computable subsets of $\mathbb{N}$ for some f $\epsilon \mathcal{C}[O, 1]$ of non-total degree; and there are computably incomparable f, g $\epsilon \mathcal{C}[0, 1]$ which compute exactly the same subsets of $\mathbb{N}$ . Proofs draw from classical analysis and constructive analysis as well as from computability theory. (shrink)

The model of incomplete cooperative games incorporates uncertainty into the classical model of cooperative games by considering a partial characteristic function. Thus the values for some of the coalitions are not known. The main focus of this paper is 1-convexity under this framework. We are interested in two heavily intertwined questions. First, given an incomplete game, how can we fill in the missing values to obtain a complete 1-convex game? Second, how to determine in a rational, fair, and efficient way (...) the payoffs of players based only on the known values of coalitions? We illustrate the analysis with two classes of incomplete games—minimal incomplete games and incomplete games with defined upper vector. To answer the first question, for both classes, we provide a description of the set of 1-convex extensions in terms of its extreme points and extreme rays. Based on the description of the set of 1-convex extensions, we introduce generalisations of three solution concepts for complete games, namely the τ\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\tau $$\end{document}-value, the Shapley value and the nucleolus. For minimal incomplete games, we show that all of the generalised values coincide. We call it the average value and provide different axiomatisations. For incomplete games with defined upper vector, we show that the generalised values do not coincide in general. This highlights the importance and also the difficulty of considering more general classes of incomplete games. (shrink)

This multi-centre research investigates the effects of dance movement therapy (DMT) on participants diagnosed with depression. In total, 109 persons participated in the study in various locations in Finland. The participants were 39 years old, on average (range = 18–64 years), and most were female (96%). All participants received treatment as usual (TAU). They were randomised into DMT+TAU (n = 52) or TAU-only (n = 57). The participants in the DMT + TAU group were offered 20 DMT sessions twice a (...) week for 10 weeks in addition to standard care. The measurement points included pre-treatment measurement at the baseline, post-treatment measurement at the end of the intervention, and a follow-up measurement 3 months afterward. The observed effects of the intervention among participants in the DMT+TAU group were a greater reduction in depression (BDI-I) and in indicators of physical and psychological distress (CORE-OM and SCL-90) in comparison to the participants who received TAU-only. At the 3-month follow-up, the corrected between-group effect sizes (ES) were medium and in favour of the DMT+TAU group (d = 0.60–0.72). These results are in line with the increasing number of research studies showing the benefits of DMT intervention among participants with depression, and these results indicate that DMT may improve the effectiveness of standard care. (shrink)

Lecture audiences and students were asked to respond to virtual decision and game situations at gametheory.tau.ac.il. Several thousand observations were collected and the response time for each answer was recorded. There were significant differences in response time across responses. It is suggested that choices made instinctively, that is, on the basis of an emotional response, require less response time than choices that require the use of cognitive reasoning.