Reprogramming of somatic cells to a pluripotent state holds huge potentials for regenerative medicine. However, a debate over which method is better, somatic cell nuclear transfer (SCNT) or induced pluripotent stem (iPS) cells, still persists. Both approaches have the potential to generate patient‐specific pluripotent stem cells for replacement therapy. Yet, although SCNT has been successfully applied in various vertebrates, no human pluripotent stem cells have been generated by SCNT due to technical, legal and ethical difficulties. On the other hand, human (...) iPS cell lines have been reported from both healthy and diseased individuals. A recent study reported the generation of triploid human pluripotent stem cells by transferring somatic nuclei into oocytes, a variant form of SCNT. In this essay, we discuss this progress and the potentials of these two reprogramming approaches for regenerative medicine. (shrink)

This paper aims at investigating the dynamic characteristics of a microring driven by dual arch electrodes because they are basic elements of microelectrostatic motors. The dual arch electrodes surround the periphery of the microring and are arranged symmetrically to the center of the ring. The electrodes are fixed while the microring is flexible. The electrostatic force will deform the microring, while the deflection of the microring changes the gap between the microring and the electrodes, thereby changing the electrostatic force. Therefore, (...) this is an electromechanical coupling effect. The nonlinear partial-differential equation that governs the motion of the microring is derived based on thin shell theory. Then, based on the assumption of small deflection, the nonlinear governing equation is linearized by truncating the higher-order terms of the Taylor series expansion of the nonlinear electrostatic force. After that, the linearized governing equation is discretized into a set of ordinary differential equations using Galerkin method in which the mode shape functions of the ring are adopted. The influences of the structural damping of the microring and the span of the arch electrodes on the forced response and dynamical stabilities of the microring are investigated. The results show that the damping ratio has a great influence on the system instability during high-frequency excitation. The unstable region of the system can increase with the increase of the electrode span; the response amplitude can also be increased within a certain range. (shrink)

Most neuroimaging research in stroke rehabilitation mainly focuses on the neural mechanisms underlying the natural history of post-stroke recovery. However, connectivity mapping from resting-state fMRI is well suited for different neurological conditions and provides a promising method to explore plastic changes for treatment-induced recovery from stroke. We examined the changes in resting-state functional connectivity (RS-FC) of the ipsilesional primary motor cortex (M1) in 10 post-acute stroke patients before and immediately after 4 weeks of robot-assisted bilateral arm therapy (RBAT). Motor performance, (...) functional use of the affected arm, and daily function improved in all participants. Reduced interhemispheric RS-FC between the ipsilesional and contralesional M1 (M1-M1) and the contralesional-lateralized connections were noted before treatment. In contrast, greater M1-M1 functional connectivity and disturbed resting-state networks were observed after RBAT relative to pre-treatment. Increased changes in M1-M1 RS-FC after RBAT were coupled with better motor and functional improvements. Mediation analysis showed the pre-to-post difference in M1-M1 RS-FC was a significant mediator for the relationship between motor and functional recovery. These results show neuroplastic changes and functional recoveries induced by RBAT in post-acute stroke survivors and suggest that interhemispheric functional connectivity in the motor cortex may be a neurobiological marker for recovery after stroke rehabilitation. (shrink)

Given the current popularization of computer programming and the trends of informatization and digitization, colleges have actively responded by making programming lessons compulsory for students of all disciplines. However, students from different ethnic groups often have different learning responses to such lessons due to their respective cultural backgrounds, the environment in which they grew up, and their consideration for future employment. In this study, an AI-assisted programming module was developed and used to compare the differences between multi-ethnic college students in (...) terms of their theoretical and actual learning expectancy, motivation, and effectiveness. The module conducted analysis through the deep learning network and examined the relevant processes that the students underwent during programming lessons, as well as the types of errors they had committed. Their learning motivation for and actual learning performance in programming were then examined based on the cognitive learning theory. The results of the experiment, which involved 96 multi-ethnic college students, indicated that the two groups had dissimilar theoretical performance in terms of their expectancy and motivation for learning programming. The indigenous students’ main concern was whether programming would affect their families or tribes, and this concern affected and was reflected in their learning outcomes. In contrast, the learning motivation and goals of Han Chinese students were driven by the cognition of the value of programming to themselves. The research findings can contribute toward the cognition and understanding of multi-ethnic students when learning computer programming and development of the appropriate teaching methods, and serve as a reference for subsequent research on integrating multiculturalism into computer programming lessons. (shrink)

Drawing on ancient and modern sources, "a lucid discussion of Taoism and the Chinese language [that's] profound, reflective, and enlightening." —Boston Globe According to Deepak Chopra, "Watts was a spiritual polymatch, the first and possibly greatest." Watts treats the Chinese philosophy of Tao in much the same way as he did Zen Buddhism in his classic The Way of Zen. Critics agree that this last work stands as a perfect monument to the life and literature of Alan Watts. "Perhaps the (...) foremost interpreter of Eastern disciplines for the contemporary West,... Watts begins with scholarship and intellect and proceeds with art and eloquence to the frontiers of the spirit."—Los Angeles Times. (shrink)

Background and aimDuring the COVID-19 pandemic, an Internet-Mindfulness-Based Stress Reduction program was delivered and may be better than an in-person approach. Our study evaluated the effects of iMBSR intervention on mental health, self-efficacy, and body image in women with breast cancer in Taiwan.Materials and methodsSixty-seven women with breast cancer were allocated to a 6-week iMBSR program or a waitlist control group, without heterogeneity between group characteristics. Patients from both groups were measured at baseline and postintervention using three scales: Depression, Anxiety, (...) and Stress Scale, General self-efficacy scale, and Body Image Scale. Descriptive dataset analysis, paired t-test, and Student’s t-test were used to evaluate the data.ResultsAlthough iMBSR did not significantly improve depression and stress between groups, iMBSR could improve anxiety with medium effect sizes. Significant benefits were found for body image and self-efficacy, with large effect sizes.ConclusionOur preliminary study supports iMBSR as a program that can improve mental health, body image, and self-efficacy in women with breast cancer. During the COVID-19 pandemic, medical professionals can use Internet-based clinical health education. (shrink)

How the Tao applies to the ecological understanding of the human environment for the purpose of human well-being as well as for the hannony of nature is an interesting and crucial issue for both environmentalists and philosophers of the Tao. I formulate five basic axioms for an environmental ethic of the Tao: the axiom of total interpenetration; the axiom of self-transformation; the axiom of creative spontaneity; the axiom of a will not to will; and the axiom of non-attaching attachment. I (...) show that each axiom generates important consequences for environmental ethics and that together they provide a necessary foundation for environmental ethics. (shrink)

Zi xin Zhongguo cheng li yi lai, sui zhe Zhongguo she hui wen hua de xi ju xing bian qian, Zhongguo wen yi xue ye jing li le duo ci zhuan xing, ben shu zai yi"shi" wei zhu yao xian suo de ji chu shang, yi wen yi xue si chao wei zhu ti an pai zhang jie jie gou.

Abstract Universality, rather than partiality, is the characteristic of Confucian jen. This article puts forward three arguments to clarify confusion of interpretation: (1) that jen, rather than shu, is the main thread running through the whole system of Confucianism, and that by its two procedures of chung and shu, it presents itself as an integration of one's self with others; (2) that jen, as love, does not signify a natural preference, but an ethical refinement of an ordinary feeling of (...) fondness, that it derives from such a feeling but goes beyond it, and that it functions as a universal commitment which begins with family affection but is not limited to it; (3) that jen, as universal love, is deontological in motive, not only in contrast to a mutuality of love but also in opposition to a utilitarianism of love. (shrink)

A new translation of the 6th-century Taoist text Bai Yao Lu (Statutes of the Hundred Remedies), with practical commentary. Explains how the Hundred Remedies of the Bai Yao Lu offer a practical guide to what enlightened or sagely behavior looks like. Shows how each short verse of the Hundred Remedies presents a spiritual precept as a solution to the problems encountered in daily life and on the spiritual path. Provides insightful commentary for each of the Hundred Remedies, showing how they (...) relate to meditation practice and can help us navigate emotional and social challenges. (shrink)

Ben shu zhu yao tao lun qing dai zhong ye li xue si xiang de xing qi.

Ben shu tan tao le Song Ming li xue yu Ming dai wen xue de guan xi, bing yi ren ge feng fan wei zhong dian shen ru yan jiu le Ming dai wen xue de chuang zuo yu liu bian, jian gou le Ming dai wen xue de chuang zuo yu liu bian jian gou le Ming dai wen xue de fa zhan ti xi, dui Ming dai zhong yao zuo jia, zuo pin ti chu le du dao de (...) kan fa. (shrink)

Ben shu zhu yao yan yong bing zun xun "li shi yu luo ji xiang tong yi" de yuan ze he fang fa, xiang xi shu li, jian tao zuo wei ming dai zhong qi si xiang jia de Huang Wan, qi yi sheng dao xue si xiang jin zhan guo cheng zhong cong Song ru zhi xue (li xue) dao Wang Yangming liang zhi xue (xin xue), zai dao hui gui jing dian (jing xue) de yan bian li cheng, (...) yi qi lun zheng qi xue shu yan bian fan shi zhi yu Ming Qing xue shu zhuan xing de "xian dao xing" dian fan yi yi. (shrink)

Ben shu zhu yao tao lun qing dai zhong ye li xue si xiang de xing qi.

Ben shu yi xing wei wu jia zhi er yuan lun wei yan jiu zhu xian, an zhao " ke guan gou cheng yao jian, pai chu ke guan wei fa de shi you, zhu guan gou cheng yao jian, pai chu zhu guan ze ren de shi you " si jie ceng fan zui lun ti xi de jia gou, cong ke guan yao jian, zhu guan yao jian, xiu zheng xing tai san ge wei du, lin xuan fan (...) zui lun ling yu de ruo gan zheng yi wen ti yi ci zhan kai tao lun. ben shu jian chi yi wen ti wei dao xiang, wei rao si fa shi jian ti chu de nan ti, shu li xue shuo de mai luo, kao cha li fa de tuo dang xing, dui ge zhong li lun he guan dian tiao fen lü xi, zhi li yu li lun, li fa yu si fa de liang xing hu dong he xie diao fa zhan, ti chu de fang an zai yi ding cheng du shang hui da le li lun he shi jian zhong de yi wen. (shrink)

This volume contains the major papers presented at the Second International Conference of the International Society For Metaphysics held at Visva-Bharati University, Santiniketan, West Bengal, India. The Society was conceived at the 14th International Congress of Philosophy meeting in Vienna in 1968, sponsored by leading members of the Metaphysical Society Of America, and was initiated at the International Congress of Philosophy held at Varna, Bulgaria in 1973. This is the first volume of their proceedings to be published. Subsequent volumes are (...) in preparation presenting the meetings in New York, also in 1976, and in Jerusalem in 1977. The theme of the Calcutta meeting in India was "Man And Nature," reflecting the renewed import of discussions of nature evident in the twentieth century, including the limits and possibilities it may offer for human personality. The depth and variety of the metaphysical analysis is too complex for serious comment in this brief space. The pluralism, geographical diversity and range of the conference is most evident from the contents of this volume: Part I, Science And Nature, includes papers by E. Agazzi, A. Mercier, and E. E. Harris. Part II, Progress and Nature, includes papers by M. Chatterjee, J. E. Smith, J. Kuszynski, A. N. Woznicki, and S. Chakravarti. Part III, Person And Nature, includes papers by K. Bhattacharya, S. C. Thakur, C. Chung-yuan, and T. A. Fay. Part IV, Transcendence And Nature, includes papers by M. Abe, K. K. Banerjee, T. M. P. Mahadevan, W. N. Clarke, E. Deutsch, and B. Bhattacharya. The essays offer considerations of animism, aesthetics, buddhism, causality, existentialism, Marxism, pragmatism, Tao, and conclude with a tribute to R. Tagore. It is most appropriate that in this journal congratulations be offered to the International Society For Metaphysics for the success of its early endeavors, and for this initial contribution to international discussion as evidence of the vitality of metaphysical reflection.--Harold A. Durfee, American University. (shrink)