This volume brings together essays that explore the intersections between Nietzsche and Wittgenstein from various perspectives. While some chapters focus on the philological and biographical connections of Wittgenstein's reading of Nietzsche, others reflect on the ideas that are implicitly shared by the two thinkers. For Nietzsche and Wittgenstein, philosophy is inextricably connected to ethics and the arts and therefore takes a peculiar method that differs from the sciences. Nevertheless, their thinking strives for knowledge and truth by means of discursive text (...) forms, however unconventional they may be. The first group of chapters contextualize explicit references to Nietzsche in Wittgenstein's writings and clarify their philosophical function. In Part II, the contributors take a philosophical problem as their starting point and show how it can be illuminated by comparing or contrasting Wittgensteinian and Nietzschean arguments and methods. Together the chapters trace Nietzsche's influence on Wittgenstein's thought concerning the critique of language, ethics, aesthetics, religion, and philosophical method. Wittgenstein and Nietzsche will be of interest to scholars and advanced students working in the history of philosophy and intellectual history. (shrink)

The present study reports on the use of a linguistic category "interrogative," which has been traditionally associated with the act of questioning, and its use in argument talk in Japanese. Based on the observation that interrogative utterances in argument data are regularly followed by non-answers, it is argued that interrogative utterances in argument sequences may not be designed/interpreted as doing questioning. Such use of interrogatives can become an orderly practice to which participants orient themselves in social activities recognizable as arguments. (...) However, though an answer is not expected, the recipient invariably provides some form of response, or the initial speaker seeks such a response when none is provided. Thus the nature of interrogatives as a grammatical category seems to reside in the basic structural unit of social interaction [recipient-oriented action]-[response]. In general, this study is intended to show the dynamically interlocking relationship between grammar and interaction by exploring the intricate interplay between a local action for which interrogative grammar is employed, and the sequential environment and activity framework in which the action takes place. (shrink)

Background The purpose of this study is to explore laypersons' attitudes toward the use of archived (existing) materials such as medical records and biological samples and to compare them with the attitudes of physicians who are involved in medical research. Methods Three focus group interviews were conducted, in which seven Japanese male members of the general public, seven female members of the general public and seven physicians participated. Results It was revealed that the lay public expressed diverse attitudes towards the (...) use of archived information and samples without informed consent. Protecting a subject's privacy, maintaining confidentiality, and communicating the outcomes of studies to research subjects were regarded as essential preconditions if researchers were to have access to archived information and samples used for research without the specific informed consent of the subjects who provided the material. Although participating physicians thought that some kind of prior permission from subjects was desirable, they pointed out the difficulties involved in obtaining individual informed consent in each case. Conclusions The present preliminary study indicates that the lay public and medical professionals may have different attitudes towards the use of archived information and samples without specific informed consent. This hypothesis, however, is derived from our focus groups interviews, and requires validation through research using a larger sample. (shrink)

Adolescents’ and young adults’ practical moral judgments about two interpersonal moral dilemmas, which differed in their moral complexity, were examined using two philosophical frameworks (deontological and consequentialist principles) as tools for psychological analysis. A sample of 234 participants (ages 14–16, 18–19, and 20–21) reasoned about two moral dilemmas, which had been experienced by a subset of adolescents in a pilot study, in two forms: Participants 1) provided open-ended decisions and justification from the perspective of an imagined moral agent and 2) (...) selected a choice from nine fixed reasoning alternatives (half advocating one course and other half advocating the other course of action, plus a relativistic reasoning). The participants’ open-ended responses served as a foundation of coding systems and were analyzed using log-linear analyses, chi-square tests, and a binominal logistic regression. The combination of qualitative and quantitative methods uncovered unexpected but nuanced young people’s moral thinking. Results indicated that female participants were more likely than males to show a unique decision style: “restructuring” of the moral dilemmas/situations, and moral relativism emerged only when asked to select a choice from nine reasoning alternatives and was primarily evidenced among the younger (aged 18–19) female college students. (shrink)

The present study reports on the use of a linguistic category "interrogative," which has been traditionally associated with the act of questioning, and its use in argument talk in Japanese. Based on the observation that interrogative utterances in argument data are regularly followed by non-answers, it is argued that interrogative utterances in argument sequences may not be designed/interpreted as doing questioning. Such use of interrogatives can become an orderly practice to which participants orient themselves in social activities recognizable as arguments. (...) However, though an answer is not expected, the recipient invariably provides some form of response, or the initial speaker seeks such a response when none is provided. Thus the nature of interrogatives as a grammatical category seems to reside in the basic structural unit of social interaction [recipient-oriented action]-[response]. In general, this study is intended to show the dynamically interlocking relationship between grammar and interaction by exploring the intricate interplay between a local action for which interrogative grammar is employed, and the sequential environment and activity framework in which the action takes place. (shrink)

Regarding strictly monadic second‐order logic (SMSOL), which is the fragment of monadic second‐order logic in which all predicate constants are unary and there are no function symbols, we show that a standard deductive system with full comprehension is sound and complete with respect to standard semantics. This result is achieved by showing that in the case of SMSOL, the truth value of any formula in a faithful identity‐standard Henkin structure is preserved when the structure is “standardized”; that is, the predicate (...) domain is expanded into the set of all unary relations. In addition, we obtain a simpler proof of the decidability of SMSOL. (shrink)

Dogs and cats have been domesticated through different processes. Dogs were the first domesticated animals, cooperating with humans by hunting and guarding. In contrast, cats were domesticated as predators of rodents and lived near human habitations when humans began to settle and farm. Although the domestication of dogs followed a different path from that of cats, and they have ancestors of a different nature, both have been broadly integrated into—and profoundly impacted—human society. The coexistence between dogs/cats and humans is based (...) on non-verbal communication. This review focuses on “gaze,” which is an important signal for humans and describes the communicative function of dogs’ and cats’ eye-gaze behavior with humans. We discuss how the function of the gaze goes beyond communication to mutual emotional connection, namely “bond” formation. Finally, we present a research approach to multimodal interactions between dogs/cats and humans that participate in communication and bond formation. (shrink)

ABSTRACT Objectives: the purpose of this study is to explore laypersons’ attitudes towards and experiences of medical research, and to compare them with those of physicians in Japan. Designs and Participants: fourteen Japanese adults from the general public and seven physicians participated in one of three focus interviews. Setting: Osaka, Japan. Results: trust and distrust in the physician by whom the participants were invited to participate in research played a considerable role in their decisions about participation. That the participants felt (...) an obligation to participate was also expressed. The lay participants perceived medical research as something entirely outside of their world. A greater willingness to volunteer for research was expressed if there were direct benefits to themselves or their families. Research methods such as use of placebos, double blinds, and randomisations seemed to cause negative attitudes to medical research. All physicians were convinced of the need for medical research, including double‐blinded randomised control trials, and its significant role in medical progress. Most physicians thought that the greater awareness of the need for medical research in the community and a better understanding of the psychology of potential research participants were necessary and urgent. Conclusions: there is a good possibility that the lay public and medical professionals have sharply different beliefs about and attitudes towards every aspect of medical research. Building up a better and equal patient‐doctor relationship based on trust is a key issue in medical research, and it is mandatory to fill the gap in perception regarding medical research between them through fully informed debates. (shrink)

Variation in decision-making about end-of-life care among ethnic groups creates clinical conflicts. In order to understand changes in preferences for end-of-life care among Japanese who immigrate to the United States, we conducted 18 focus groups with 122 participants: 65 English-speaking Japanese Americans, 29 Japanese-speaking Japanese Americans and 28 Japanese living in Japan.Negative feelings toward living in adverse health states and receiving life-sustaining treatment in such states permeated all three groups. Fear of being meiwaku, a physical, psychological or financial caregiving burden (...) on loved ones, was a prominent concern. They preferred to die pokkuri (popping off) before they become end stage or physically frail. All groups preferred group-oriented decision-making with family. Although advance directives were generally accepted, Japanese participants saw written directives as intrusive whereas Japanese Americans viewed them mainly as tools to reduce conflict created by dying person's wishes and a family's kazoku no jo– responsibility to sustain the dying patient. These findings suggest that in the United States Japanese cultural values concerning end-of-life care and decision-making process are largely preserved. (shrink)

Replication forks inevitably stall at damaged DNA in every cell cycle. The ability to overcome DNA lesions is an essential feature of the replication machinery. A variety of specialized polymerases have recently been discovered, which enable cells to replicate past various forms of damage by a process termed translesion synthesis. Alternatively, homologous recombination can be used to restart DNA replication across the lesion. Genetic and biochemical studies have shed light on the impact of these two post‐replication repair pathways in bacteria (...) and yeast. In vertebrates, however, a genetic approach to study post‐replication repair has been compromised because many of the genes involved appear to be essential for embryonic development. We have taken advantage of the chicken cell line DT40 to perform a genetic analysis of translesion synthesis and homologous recombination and to characterize genetic interactions between these two pathways in vertebrates. In this article, we aim to summarize our current understanding of post‐replication repair in DT40 in the perspective of bacterial, yeast and mammalian genetics. BioEssays 26:151–158, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

The present article deals with an observer design for nonlinear vehicle lateral dynamics. The contributions of the article concern the nonconsideration of any force model and the consideration that the longitudinal velocity is time varying, which is more realistic than the assumption that it is constant. The vehicle model is then represented by an exact Takagi–Sugeno model via the sector nonlinearity transformation. A proportional multiple integral observer based on the TS model is designed to estimate simultaneously the state vector (...) and the unknown input. The convergence conditions of the estimation error are expressed under LMI formulation using the Lyapunov theory, which guaranties a bounded error. Simulations are carried out for comparison between the conventional PI observer, the enhanced PI observer, and the PMI observer. Finally, experimental results are provided to illustrate the performances of the proposed PMI observer. (shrink)

This paper investigates the aperiodic sampled-data control for a chaotic system. Firstly, Takagi–Sugeno fuzzy models for the chaotic systems are established. The lower and upper bounds of the sampling period are taken into consideration. Then, the criteria for mean square exponential stability analysis and aperiodic sampled-data controller synthesis are provided by means of linear matrix inequalities. And the real sampling patterns can be fully captured by constructing suitable Lyapunov functions. Finally, an illustrative example shows that the proposed method is (...) effective to guarantee that the system’s states are stable with aperiodic sampled data. (shrink)