The transcription factor Pax5 is essential for the initial commitment of hematopoietic progenitors to the B cell lineage. Recently, our understanding of the lineage commitment process has been extended with the finding that Pax5 is also continuously required throughout B cell development to reinforce commitment, as inactivation of Pax5 in mature B cells results in their de‐differentiation to a progenitor stage that is capable of multi‐lineage potential.1 The reliance of B cell identity on a single gene is not without its (...) problems as the loss of Pax5 results in B cell malignancies in mouse models and mutation in human PAX5 is the most‐common genetic lesion in acute lymphoblastic leukemia. BioEssays 30:203–207, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

Kritische Theorie und Philosophische Anthropologie gelten noch immer als grundsätzlich einander widerstreitende Strömungen. Die Philosophien Helmuth Plessners und Theodor W. Adornos jedoch lassen sich, so die These dieses Buches, unter dem Namen der negativen Anthropologie zusammenführen. Edinger begreift negative Anthropologie im systematischen Sinn als strukturell negativ verfasstes Konzept, um elementare und exklusive Gemeinsamkeiten zwischen Adorno und Plessner sichtbar zu machen. Neben den grundsätzlichen Überlegungen, u.a. zum Konzept der Anthropologie bei Sonnemann und Gehlen, widmet sich der Autor auch beispielhaft den Motiven (...) der Kritik der Moderne und die Kritik der Geschichtsphilosophie durch Plessner und Adorno. Damit erreicht er eine neue Sicht auf das Verhältnis der beiden philosophischen Richtungen, die die gemeinhin akzeptierte unversöhnliche Frontstellung von philosophischer Anthropologie und Kritischer Theorie aufhebt. (shrink)

In a reconstruction of the theories of Freud and Klein, Sebastian Gardner asks: what causes irrationality, what must the mind be like for it to be irrational, to what extent does irrationality involve self-awareness, and what is the point of irrationality? Arguing that psychoanalytic theory provides the most penetrating answers to these questions, he rejects the widespread view of the unconscious as a 'second mind', in favour of a view of it as a source of inherently irrational desires seeking (...) expression through wish-fulfilment and phantasy. He meets scepticism about psychoanalytic explanation by exhibiting its continuity with everyday psychology. (shrink)

I argue that the problem of responsibility for attitudes is best understood as a puzzle about how we are responsible for responding to our object-given reasons for attitudes – i.e., how we are responsible for being (ir)rational. The problem can be solved, I propose, by understanding the normative force of reasons for attitudes in terms of blameworthiness. I present a puzzle about the existence of epistemic and mental blame which poses a challenge for the very idea of reasons for attitudes. (...) We are left with three options: denying that there are any reasons for attitudes, opting for pragmatism about reasons for attitudes, or arguing that the challenge rests on a misunderstanding of the normative force of reasons for attitudes. I finally suggest a version of the last strategy. We can understand the normative force of reasons for attitudes, and thereby solve the problem of mental responsibility, by acknowledging that the way we blame each other for failing to respond correctly to our reasons for attitudes is different from the way we blame each other when one failed to respond correctly to reasons for action. (shrink)

Die Naturphilosophie und die Politische Philosophie werden gemeinhin als Disziplinen aufgefasst, die grundlegend verschiedene Problembereiche zum Gegenstand haben. Die Aporien zu überwinden, welche daraus resultieren, ist die Pointe von Plessners Philosophischer Anthropologie. In dieser Studie wird gezeigt, wie Plessner in der Aneignung elementarer Topoi der klassischen Ontologie eine strukturell neuartige "Ontologie des Organischen" entwickelt. Dieser von Plessner beiläufig verwendete Ausdruck wird in dieser Studie systematisch entwickelt. Was dabei elaboriert wird, ist eine komplexe naturphilosophische "Ontologie des Ausgleichs". In dieser Ontologie des (...) Ausgleichs werden elementare naturphilosophische Ausgleichsleistungen expliziert, die als solche einen Doppelsinn haben: was auf der organismischen Ebene strukturell als Ausgleich des organischen Körpers mit sich selbst und der Umwelt expliziert wird, nimmt im menschlichen Bereich die Gestalt einer Ontologie der Personen an, wo die strukturell identische Ausgleichsleistung als das Spiel der Personalisierung zu vollziehen ist. Plessners Ansatz wird hier als ein auf diese Fragen neuartig antwortender, gleichberechtigt als ontologischer und sozialphilosophischer Ansatz expliziert. (shrink)

Although it is an increasingly popular assumption that leader mindfulness may positively affect leader behaviors and, in turn, employee outcomes, to date, little empirical evidence supports this view. Against this backdrop, the present research seeks to develop and test a serial mediation model of leader mindfulness. Specifically, we propose that leader mindfulness enhances employee performance and that this relationship is explained by increased leader procedural justice enactment and, subsequently, reduced employees’ emotional exhaustion. We conducted three studies to test this model. (...) Study 1 involved employees from a wide range of organizations in the USA. Study 2 used a sample of leaders and employees from China and measured our model variables at three different points in time. Both studies provide consistent support for our hypotheses. Finally, Study 3 involved a laboratory experiment in which 62 senior executives were assigned to either a mindfulness induction or to a control condition. Again, results revealed a significant and positive link between leader mindfulness and leader procedural justice enactment. In sum, these findings expand our understanding of mindfulness to the domain of leadership, a key area of organizational research. Moreover, they complement prior studies by showing that mindfulness dynamics go beyond intrapersonal effects but also influence the attitudes and behaviors of others. We discuss our findings in light of their contributions to the mindfulness, ethics, and leadership literatures and point out implications for practice. (shrink)

This volume provides a framework for approaching and understanding mental normativity. It presents cutting-edge research on the ethics of belief as well as innovative research beyond the normativity of belief—and towards an ethics of mind. By moving beyond traditional issues of epistemology the contributors discuss the most current ideas revolving around rationality, responsibility, and normativity. -/- The book’s chapters are divided into two main parts. Part I discusses contemporary issues surrounding the normativity of belief. The essays here cover topics such (...) as control over belief and its implication for the ethics of belief, the role of the epistemic community for the possibility of epistemic normativity, responsibility for believing, doxastic partiality in friendship, the structure and content of epistemic norms, and the norms for suspension of judgment. In Part II the focus shifts from the practical dimensions of belief to the normativity and rationality of other mental states—especially blame, passing thoughts, fantasies, decisions, and emotions. These essays illustrate how we might approach an ethics of mind by focusing not only on belief, but also on debates about responsibility, rationality, These essays illustrate how we might approach an ethics of mind by focusing not only on belief, but also more generally on debates about responsibility and rationality, as well as on normative questions concerning other mental states or attitudes. -/- The Ethics of Belief and Beyond paves the way towards an ethics of mind by building on and contributing to recent philosophical discussions in the ethics of belief and the normativity of other mental phenomena. It will be of interest to upper-level students and researchers working in epistemology, ethics, philosophy of action, philosophy of mind, and moral psychology. (shrink)

While the meta‐ethical error theory has been of philosophical interest for some time now, only recently a debate has emerged about the question what is to be done if the error theory turns out to be true. This paper argues for a novel answer to this question, namely revolutionary expressivism: if the error theory is true, we should become expressivists. Additionally, the paper explores certain important but largely ignored methodological issues that arise for reforming definitions generally and with a vengeance (...) in the context of a radical error theory about all practical normative judgements, and suggests how these issues can be resolved. (shrink)

This chapter locates our overall approach within the dialectic of contemporary philosophical debates and provides an overall framework for discussion. First, I introduce the problem of mental normativity. I show how this problem poses a prima facie threat to the common assumption in epistemology and metaethics that beliefs and other attitudes are governed by robust normative requirements. Secondly, I motivate philosophical inquiry about an ethics of mind by tracing this field back to recent debates in the ethics of belief. I (...) characterize the ethics of mind as being concerned with two main questions: 1. How can we be responsible for our attitudes? 2. What attitudes should we have? Finally, I give an overview over the structure of the book and summarize the chapters. (shrink)

This essay explores the idea of acting from knowledge. This idea is a thought of ourselves: the distinctive way in which we act, in which we live, resides in this, that our actions, our life, may rest on knowledge. Yet the idea of action resting on knowledge is puzzling, even mysterious. The difficulty springs from the character of judgment that is knowledge: its objectivity. The objectivity of a judgment is a character of its validity: it is objectively valid. Yet it (...) is equally, and therefore, a character of the source of the reality of a valid judgment: a judgment that is knowledge is explained by nothing other than that which constitutes its validity. Now, action from knowledge partakes of this character of the knowledge on which it rests: it is explained by nothing other than what constitutes its validity, that is, its goodness. This dissolves the idea that action springs from a natural power, a power of change, a physis. That is the mystery. What could action be but the act of a natural power, and what could we be but agents of such a power? (shrink)

Essences play a central role in Spinoza’s philosophy, not only in his metaphysics, but also in his philosophy of mind, his theory of affects, and his political philosophy. Despite their importance, however, it is surprisingly difficult to determine what exactly essences are for Spinoza. On a widespread reading, the essence of X is nothing but the concept of X. This paper argues against this identification of essences and concepts. Spinozistic concepts are maximally inclusive: the concept of X contains everything that (...) is needed to make X conceivable. The essence of X, in contrast, is more limited in scope and does not include everything that is needed to make X conceivable. Thus, Spinoza avoids the ‘overloading’ of essences and the problems that would ensue. The account developed in this paper has a surprising implication, namely that the essences of non-divine, singular things do not suffice to render these things fully conceivable on Spinoza’s view. Thus, Spinoza breaks with a tradition according to which the essence of a thing states ‘what the thing is.’ As a result, his conception of essence is much further removed from traditional Aristotelian accounts, and from other seventeenth-century accounts, than usually acknowledged. (shrink)

Belief revision theory and philosophy of science both aspire to shed light on the dynamics of knowledge – on how our view of the world changes in the light of new evidence. Yet these two areas of research have long seemed strangely detached from each other, as witnessed by the small number of cross-references and researchers working in both domains. One may speculate as to what has brought about this surprising, and perhaps unfortunate, state of affairs. One factor may be (...) that while belief revision theory has traditionally been pursued in a bottom- up manner, focusing on the endeavors of single inquirers, philosophers of science, inspired by logical empiricism, have tended to be more interested in science as a multi-agent or agent-independent phenomenon. (shrink)

We present a new notion of game equivalence that captures basic powers of interacting players. We provide a representation theorem, a complete logic, and a new game algebra for basic powers. In doing so, we establish connections with imperfect information games and epistemic logic. We also identify some new open problems concerning logic and games.

We propose a new perspective on logics of computation by combining instantial neighborhood logic INL\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\mathsf {INL}$$\end{document} with bisimulation safe operations adapted from PDL\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\mathsf {PDL}$$\end{document}. INL\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\mathsf {INL}$$\end{document} is a recent modal logic, based on an extended neighborhood semantics which permits quantification over individual neighborhoods plus their contents. This system has a natural interpretation as a (...) logic of computation in open systems. Motivated by this interpretation, we show that a number of familiar program constructors can be adapted to instantial neighborhood semantics to preserve invariance for instantial neighborhood bisimulations, the appropriate bisimulation concept for INL\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\mathsf {INL}$$\end{document}. We also prove that our extended logic IPDL\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\mathsf {IPDL}$$\end{document} is a conservative extension of dual-free game logic, and its semantics generalizes the monotone neighborhood semantics of game logic. Finally, we provide a sound and complete system of axioms for IPDL\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\mathsf {IPDL}$$\end{document}, and establish its finite model property and decidability. (shrink)

Research on value congruence rests on the assumption that values denote desirable behaviors and ideals that employees and organizations strive to approach. In the present study, we develop and test the argument that a more complete understanding of value congruence can be achieved by considering a second type of congruence based on employees’ and organizations’ counter-ideal values. We examined this proposition in a time-lagged study of 672 employees from various occupational and organizational backgrounds. We used difference scores as well as (...) polynomial regression and response surface analyses to test our hypotheses. Consistent with our hypotheses, results reveal that counter-ideal value congruence has unique relations to employees’ trust in the organization that go beyond the effects of ideal value congruence. We discuss theoretical and practical implications of this expanded perspective on value congruence. (shrink)

The well known AGM framework for belief revision has recently been extended to include a model of the research agenda of the agent, i.e. a set of questions to which the agent wishes to find answers (Olsson & Westlund in Erkenntnis , 65 , 165–183, 2006 ). The resulting model has later come to be called interrogative belief revision . While belief revision has been studied extensively from the point of view of modal logic, so far interrogative belief revision has (...) only been dealt with in the metalanguage approach in which AGM was originally presented. In this paper, I show how to model interrogative belief revision in a modal object language using a class of operators for questions. In particular, the solution I propose will be shown to capture the notion of K-truncation , a method for agenda update in the case of expansion constructed by Olsson & Westlund. Two case studies are conducted: first, an interrogative extension of Krister Segerberg’s system DDL, and then a similar extension of Giacomo Bonanno’s modal logic for belief revision. Sound and complete axioms will be provided for both of the resulting logics. (shrink)

This article presents a characterization of higher-order risk preferences such as prudence or temperance in terms of statistical moments. Our results, which are generalizations of Roger :27–44, 2011) and Ekern, 329–333, 1980), give a better understanding of how higher-order risk preferences relate to skewness preference and kurtosis aversion. While they are not based on expected utility theory, an implication within that theory is that all commonly used utility functions exhibit skewness preference and kurtosis aversion.

Volume 10, Issue 2, June 2019, Page 222-228.

La paix entre l’État et les FARC en 2016 a fortement limité le nombre de victimes de violences mais ces dernières risquent de repartir de plus belle. La moitié des guérilleros ont été désarmés par l’ONU, ce qui laisse le pays sans encadrement territorial pour s’opposer au narcotrafic. Les anciens FARC sont assassinés par de nouvelles structures criminelles en train d’occuper le terrain.

Leibniz repeatedly states that there is a very close connection between reflection and rationality. In his view, reflective acts somehow lead to self-consciousness, reason, the knowledge of necessary truths, and even to the moral liability of the respective substances. Whereas it might be relatively easy to see how reflective acts lead to self-consciousness, it is much harder to understand how they are connected to rationality. Why should a substance which is able to produce reflective acts therefore be rational? How can (...) the having of reflective acts be responsible for the substance’s ability to reason correctly and to acquire knowledge of necessary and eternal truths? The aim of my paper is to understand better the required mechanisms and to make thus conceivable Leibniz’s bold claim that reflective acts lead to rationality. In order to accomplish this, I will proceed in three steps. First, I will specify what kind of self-consciousness is, according to Leibniz, produced by reflective acts. A substance must recognize itself as a unitary substance bearing perceptions. Second, I will argue that this type of self- consciousness can be seen as the basis for the ability to form judgments. This is possible because the subject-predicate structure of judgments is mirrored by the ontology of substances and their modifications. Third, I will point out that, together with the idea of identity (which we also acquire by reflection), the combination of judgments allows us to make inferences. This ability, in turn, is sufficient for rationality. Thus, I can explain how reflective acts and rationality are connected with each other. (shrink)

Transformative theories of what distinguishes human beings from animals face the problem of conceptually managing the transition from animal to human. This paper will show that this transition contains logical problems that are more rhetorically glossed over than logically solved by the concept of second nature. In the first part, I develop two main concepts of transformative theories, namely that of Hinzutreten (additive capacities occurring in humans) and that of Verwandeltsein (humans already being of a different kind), before outlining in (...) the second part Helmuth Plessner’s anthropological approach as one that elaborates not a transformation, but a holistic difference in the structure of human life as well as a non-metaphysical process of nature’s self-differentiation in human beings as opposed to animals. (shrink)

In the paper "On the role of the research agenda in epistemic change", Olsson and Westlund have suggested that the notion of epistemic state employed in the standard framework of belief revision (Alchourrón et al. 1985; Gärdenfors 1988) should be extended to include a representation of the agent's research agenda (Olsson and Westlund 2006). The resulting framework will here be referred to as interrogative belief revision. In this paper, I attempt to deal with the problem of how research agendas should (...) change in contraction, a problem largely left open by Olsson and Westlund. Two desiderata of an appropriate solution are suggested: one is a principle of continuity, stating that changes in the research agenda should somehow reflect that certain long term research interests are kept fixed. The other desideratum, which is based on part of Olsson and Westlund's motivation for adding research agendas to the epistemic states, is that we should be able to account for how contraction may serve to open up new, fruitful hypotheses for investigation. In order to achieve these desiderata, I base my solution on a revised version of Olsson and Westlund's notion of epistemic state. (shrink)

The Principle of the Identity of Indiscernibles —the principle that no two numerically distinct things are perfectly similar—features prominently in Leibniz’s metaphysics. Despite its centrality to his philosophical system, it is surprisingly difficult to determine what modal status Leibniz ascribes to the PII. On many occasions Leibniz appears to endorse the necessity of the PII. There are a number of passages,however, where Leibniz seems to imply that numerically distinct indiscernibles are possible, which suggests that he subscribes to a merely contingent (...) version of the PII. In this paper I attempt to resolve this apparent inconsistency. I argue that Leibniz consistently takes the PII to be necessary and that this view of his shines through even in his correspondence with Clarke. I also show that competing interpretations, on which Leibniz’s PII is contingent, misread a number of crucial passages from this correspondence. (shrink)

There are several known Lindström-style characterization results for basic modal logic. This paper proves a generic Lindström theorem that covers any normal modal logic corresponding to a class of Kripke frames definable by a set of formulas called strict universal Horn formulas. The result is a generalization of a recent characterization of modal logic with the global modality. A negative result is also proved in an appendix showing that the result cannot be strengthened to cover every first-order elementary class of (...) frames. This is shown by constructing an explicit counterexample. (shrink)

Research on the asymmetric effect of negative versus positive affective states on scope of attention, both at a perceptual and a conceptual level, is abundant. However,...

I develop a dynamic logic for reasoning about "interrogative belief revision", a new branch of belief revision theory that has been developed in a small number of papers, beginning with E. J. Olsson and D. Westlund's paper "On the role of the research agenda in epistemic change" [12]. In interrogative belief revision, epistemic states are taken to include a research agenda, consisting of questions the agent seeks to answer. I present a logic for revision of such epistemic states based on (...) the notion of an epistemic strategy, a stable plan of action that determines changes in the agent's research agenda. This idea is a further development of an idea put forward in [6], that changes in the research agenda of an agent should be determined by stable, "long term" research interests. I provide complete axioms and a decidability result for the logic. (shrink)

Schools in Germany are frequently named after people. Thus, these persons are remembered in the public sphere. This article answers the question to what extent the school names in the federal state of Thuringia correspond with the history of scientific pedagogy. For this purpose, in a first step, the controversial discussion about key figures in pedagogy and history of education is presented. In a second step the entirety of all school names in Thuringia is considered and individual results are discussed. (...) As a rule, it is not pedagogues who lend their names to schools but writers, artists and political figures. Only one fifth of all schools named after a person are named after educators. It is found that the key figures in pedagogy are rarely available as namesakes, whereas in practice successful school founders are preferred as name-givers. Accordingly, the history of pedagogy is represented in a filtered way in school names. Based on these results, further research perspectives for research on school names are formulated. (shrink)

We characterize the expressive power of the modal mu-calculus on monotone neighborhood structures, in the style of the Janin-Walukiewicz theorem for the standard modal mu-calculus. For this purpose we consider a monadic second-order logic for monotone neighborhood structures. Our main result shows that the monotone modal mu-calculus corresponds exactly to the fragment of this second-order language that is invariant for neighborhood bisimulations.

The article talks of an evolution of a Biblical notion of Law. The author shows the way, the meaning of the Hebrew term “Torah” was transformed throughout the Pentateuch, in the prophetic tradition and in the wisdom books. He puts into analysis the relationship between the Judaism as a religious formation and the Law as a code. The Law included basic regulations to the moral, religious and political life of Israel.

We define an applicative theory of truth TPTTPT which proves totality exactly for the polynomial time computable functions. TPTTPT has natural and simple axioms since nearly all its truth axioms are standard for truth theories over an applicative framework. The only exception is the axiom dealing with the word predicate. The truth predicate can only reflect elementhood in the words for terms that have smaller length than a given word. This makes it possible to achieve the very low proof-theoretic strength. (...) Truth induction can be allowed without any constraints. For these reasons the system TPTTPT has the high expressive power one expects from truth theories. It allows embeddings of feasible systems of explicit mathematics and bounded arithmetic.The proof that the theory TPTTPT is feasible is not easy. It is not possible to apply a standard realisation approach. For this reason we develop a new realisation approach whose realisation functions work on directed acyclic graphs. In this way, we can express and manipulate realisation information more efficiently. (shrink)

The term ‘apologies’ describes prayers offered by Christians during Mass to express their sinfulness and unworthiness. In liturgical scholarship, these prayers have usually been regarded as early medieval priestly prayers, and it has been argued that they largely vanished after their peak of importance in the 11th century Order of Mass. In my article, I show that these prayers did not disappear but are transmitted in late medieval private prayer books. In light of this transmission, I propose to conjoin scholarly (...) perspectives from liturgical studies and cultural history in order to understand apologies as expressions of devotional individuation. (shrink)