Descartes est, dans le fait, le vrai fondateur de la philosophie moderne, en tant qu'elle prend la pensée pour principe. L'action de cet homme sur son siècle et sur les temps nouveaux ne sera jamais exagérée. C'est un héros ; il a repris les choses par les commencements, et il a retrouvé de nouveau le vrai sol de la philosophie, auquel elle est revenue après un égarement de mille ans. 1637, c'est la date de la publication du Discours de la (...) méthode, de René Descartes - véritable déclaration des droits et des pouvoirs de la Raison sur un monde qu'elle domine et organise. Toute la pensée moderne est née de cet ouvrage dont la langue, dense mais toujours claire, n'a pas vieilli. (shrink)

The involvement of developing countries in international clinical trials is necessary for the development of appropriate medicines for local populations. However, the absence of appropriate structures for ethical review represents a barrier for certain countries. Currently there is very little information available on existing structures dedicated to ethics in western and central Africa. This article briefly describes historical milestones in the development of networks dedicated to capacity building in ethical review in these regions and outlines the major conclusions of two (...) workshops on this issue, which were held in September and October 2002 in Libreville, Gabon, and Paris, France. The workshops were the culmination of collaboration between the African Malaria Network Trust (AMANET) and the Pan African Bioethics Initiative (PABIN). They produced an update on ethics organizations with regard to mission, function, activities, members, and contact people, in eight countries within the regions discussed. As a result of the commitment of mandated delegates, a further prominent outcome followed these workshops: the creation of national structures, where none existed before, dedicated to the ethical review of clinical trials. (shrink)

Gauge symmetries play a central role, both in the mathematical foundations as well as the conceptual construction of modern (particle) physics theories. However, it is yet unclear whether they form a necessary component of theories, or whether they can be eliminated. It is also unclear whether they are merely an auxiliary tool to simplify (and possibly localize) calculations or whether they contain independent information. Therefore their status, both in physics and philosophy of physics, remains to be fully clarified. In this (...) overview we review the current state of affairs on both the philosophy and the physics side. In particular, we focus on the circumstances in which the restriction of gauge theories to gauge invariant information on an observable level is warranted, using the Brout-Englert-Higgs theory as an example of particular current importance. Finally, we determine a set of yet to be answered questions to clarify the status of gauge symmetries. (shrink)

The involvement of developing countries in international clinical trials is necessary for the development of appropriate medicines fo.

This article sets down the foundations of a research project on Health and Physical Education (HPE) teachers’ job satisfaction and job embededness. According to the literature, HPE teachers has a weak status inside and outside school which may conduct to professional marginalization. After describing the situation of the teaching profession in the province of Québec, the focus is directed toward HPE as a teaching specialty. A conceptual framework that articulates job satisfaction and job embededness models is then proposed. In conclusion (...) of this theoretical reflexion, considering the actual teacher shortage, school organizations are invited to adhere to a more sustainable approach of teaching resources management. (shrink)

New concepts may prove necessary to profit from the avalanche of sequence data on the genome, transcriptome, proteome and interactome and to relate this information to cell physiology. Here, we focus on the concept of large activity-based structures, or hyperstructures, in which a variety of types of molecules are brought together to perform a function. We review the evidence for the existence of hyperstructures responsible for the initiation of DNA replication, the sequestration of newly replicated origins of replication, cell division (...) and for metabolism. The processes responsible for hyperstructure formation include changes in enzyme affinities due to metabolite-induction, lipid-protein affinities, elevated local concentrations of proteins and their binding sites on DNA and RNA, and transertion. Experimental techniques exist that can be used to study hyperstructures and we review some of the ones less familiar to biologists. Finally, we speculate on how a variety of in silico approaches involving cellular automata and multi-agent systems could be combined to develop new concepts in the form of an Integrated cell (I-cell) which would undergo selection for growth and survival in a world of artificial microbiology. (shrink)

François Nault | Résumé : Dans cet article, je vais aborder la question de l’identité du théologien : qui est théologien dans l’Église ? Je vais aborder les positions du dernier Concile, de Jean-Luc Marion, d’Yves Congar, de Karl Barth et enfin de René-Michel Roberge. |: In this paper, I will address the question of the identity of the theologian : who may pretend to be theologian in the Church ? I will present the positions of Vatican II, Jean-Luc Marion, (...) Yves Congar, Karl Barth and René-Michel Roberge. (shrink)

This article reports on a historical investigation carried out on the conical object MIN000-3519 preserved in the mineralogy collections of the Muséum National d'Histoire Naturelle at Paris (France). The mineralogist René-Just Haüy (1743-1822) included this object, cut in a single pyrite (FeS2) crystal, in his working collection with the references ‘Sulphured iron, mirror of the Incas, of Peru, M. de Jussieu’. All of the research lines followed lead the author to Joseph de Jussieu (1704-1779) and his shipments of botanical specimens (...) and various other samples from South America. As a member of the Godin-La Condamine-Bouguer geodesic expedition on the equator (1735-1743), he returned to France only after 36 years (1771), ill, exhausted and dispossessed of the scientific product of his Andean collections. This pyrite mirror is important because, in addition to appearing to be the only archaeological object that can be linked to Joseph's peregrinations in America, it resembles other specimens found at sites of the Cañaris culture (500-1500 AD) in Ecuador. Preserved within the de Jussieu family, this object would presumably have been given to Haüy by Joseph's heirs, his nephews Antoine-Laurent (1748-1836) or Laurent-Pierre (1792-1866), with whom he had close ties. (shrink)

The rise of big digital data is changing the framework within which linguists, sociologists, anthropologists, and other researchers are working. Semiotics is not spared by this paradigm shift. A data-driven computational semiotics is the study with an intensive use of computational methods of patterns in human-created contents related to semiotic phenomena. One of the most promising frameworks in this research program is the Semantic Vector Space (SVS) models and their methods. The objective of this article is to contribute to the (...) exploration of the SVS for a computational semiotics by showing what types of semiotic analysis can be accomplished within this framework. The study is applied to a unique body of digitized artworks. We conducted three short experiments in which we explore three types of semiotic analysis: paradigmatic analysis, componential analysis, and topic modelling analysis. The results reported show that the SVS constitutes a powerful framework within which various types of semiotic analysis can be carried out. (shrink)

According to a broadly accepted interpretation, the doubt of the First Meditation gets stronger due to an increasing effectiveness of the reasons for said doubt. I defend a deflationary reading of the doubt of the Meditations insofar as the sceptical arguments used by René Descartes gradually lose power. This reading is obviously not without consequences, which will be mentioned in the conclusion, for the interpretation of the exercise of doubt and, more fundamentally, of the Cartesian doctrine of knowledge.

Summary At the beginning of the 1730s René Antoine Ferchault de Réaumur published two long memoirs on a new type of thermometer equipped with a specially calibrated scale — known ever since as the Réaumur scale. It became one of the most common ‘standardized’ thermometers in Europe until the late nineteenth century. What made this thermometer so successful? What was it specifically? I will first argue that the real Réaumur thermometer as an instrument was a fiction, a ghost — an (...) idealized instrument. On paper, it was theoretically flawless. In reality, the standardized Réaumur thermometer was most likely never achieved. This article shows that its success was essentially due to a recontextualisation from theoretical natural philosophy — Réaumur's principle of uniformity — to: 1) the context of artisanal knowledge and practices and 2) the context of making and reporting in the Mémoires de l'Académie royale des sciences actual measurements done in the field (in Paris at the Observatory, in Provincial France, in the Colonies, and in the rest of Europe). Réaumur's thermometer was essentially a theoretical method to which was associated a particular scale. It was the instrument's reification for market consumption and fieldwork that gave this specific type of thermometer materiality and authority. Although most Réaumur thermometers ever made were strikingly different from one another, over time the thermomètre de Réaumur designation became a brand, a seal of approval born from customary artisanal practices and cultural habitudes. (shrink)

In the concluding pages of his first major book, Mensonge romantique et vérité romanesque, René Girard asserts that “Toutes les conclusions romanesques sont des conversions. Personne ne peut en douter” (All novelistic conclusions are conversions; it is impossible to doubt this).1 By this he means simply that there comes a moment when both the great novelists whom he studies and their characters recognize a fundamental truth that dramatically changes them: a life founded on human desire alone can end only in (...) misery and failure. Although not necessarily religious in nature, this novelistic conversion, as Robert Doran puts it in his recent edition of Girard’s uncollected writings on literature and literary theory .. (shrink)

Many contemporary social epistemologists take themselves to be combatting an individualist approach to knowledge typified by Descartes. Although I agree that Descartes presents an individualist picture of scientific knowledge, he does allow some practical roles for reliance on the testimony and beliefs of others. More importantly, however, his reasons for committing to individualism raise important issues for social epistemology, particularly about how reliance on mere testimony can propagate prejudices and inhibit genuine understanding. The implications of his views are worked out (...) more fully by some of his immediate successors; I examine how François Poulain de la Barre, and (briefly) Mary Astell analyze the social conditions for epistemic agency in a Cartesian vein. (shrink)

Can we solve the problem of the essential indexical, and account for de se belief, by appealing to 'relativized propositions' (functions from rich indices to truth-values)? According to John Perry, we cannot. This paper offers a detailed examination and a critique of Perry's argument.

Some recent studies have shown that the critique of rhetoric in the Gorgias itself has a rhetorical dimension. The following analysis deals only with the first part of the dialogue, in which Socrates questions Gorgias, from two complementary perspec­tives. First, since it is ad hominem in character, Socrates’ argumentation mimics and transforms the techniques of contemporary rhetoric, but its goals are protreptic and ethical rather than eristic. Secondly, insofar as he is the controlling author of the dialogue,, Plato displays strategies (...) that of course are to be distinguished from Socrates’ argumentative strategies - just as the historical Gorgias is to be distinguished from the figure represented by Plato. The distinction here focusses on the problem of interpreting the different ways in which both the character Socrates and the author Plato employ irony and indirect communication. (shrink)

L’invention au xii e siècle de la fin’amor va occuper, pour la première fois en Occident, le cœur du chant poétique, avec lequel il va entièrement s’identifier. Cette forme aristocratique, raffinée et intrinsèquement peccamineuse du sentiment amoureux exerce encore sur nos mœurs une profonde influence alors même que nous avons tendance à confondre mariage, amour et sexualité. Ne faut-il pas pourtant toujours, à l’amour, une « racine d’impossible » pour utiliser un terme commun à J. Lacan et à G. Bataille?

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work.This work is in the public domain in (...) the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work.As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

Degree-sentences, i.e. sentences that seem to refer to things that allow of degrees, are widely used both inside and outside of philosophy, even though the metaphysics of degrees is much of an untrodden field. This paper aims to fill this lacuna by addressing the following four questions: [A] Is there some one thing, such that it is degree sensitive? [B] Are there things x, y, and z that stand in a certain relation to each other, viz. the relation that x (...) has more y than z? [C] In those cases in which degree sentences do not refer to phenomena that are degree sensitive, what is responsible for their prima facie seeming to do so? [D] If there are degree sensitive things, to which ontological categories do they belong? We answer each of these questions by arguing that there are, metaphysically speaking, different phenomena that degree sentences refer to: some refer to determinates that emanate from a certain determinable, others to tokens that are instantiations of a certain type, and yet others to what we call ‘complex, resultant properties that are constituted by stereotypical properties’. Finally, we show the relevance of our answers by applying them to the notions of freedom and belief. (shrink)

The American Society for Bioethics and Humanities debated for several years about whether it should adopt positions and, if so, on what range of issues. The membership recently approved an amendment to its bylaws permitting the Society to adopt positions on matters related to academic freedom and professionalism but not on substantive moral and policy issues. This resolution is problematic for a number of reasons, including the lack of a categorical difference between these types of claims and the Society's inability (...) to speak on behalf of patients and research subjects. The implementation of the amendment also raises several issues. The Society will need to refrain from speaking too specifically and to articulate the responsibilities of its members. If the Society fails to address these concerns, it runs the risk of denigrating its public image and that of the profession. (shrink)

This article seeks to state, first, what traditionally has been assumed must be the case in order for an infinite epistemic regress to arise. It identifies three assumptions. Next it discusses Jeanne Peijnenburg's and David Atkinson's setting up of their argument for the claim that some infinite epistemic regresses can actually be completed and hence that, in addition to foundationalism, coherentism, and infinitism, there is yet another solution (if only a partial one) to the traditional epistemic regress problem. The article (...) argues that Peijnenburg and Atkinson fail to address the traditional regress problem, as they don't adopt all of the three assumptions that underlie the traditional regress problem. It also points to a problem in the notion of making probable that Peijnenburg and Atkinson use in their account of justification. (shrink)