Biochemical networks, including those containing signaling pathways, display a wide range of regulatory properties. These include the ability to propagate information across different time scales and to function as switches and oscillators. The mechanisms underlying these complex behaviors involve many interacting components and cannot be understood by experiments alone. The development of computational models and the integration of these models with experiments provide valuable insight into these complex systems‐level behaviors. Here we review current approaches to the development of computational models (...) of biochemical networks and describe the insights gained from models that integrate experimental data, using three examples that deal with ultrasensitivity, flexible bistability and oscillatory behavior. These types of complex behavior from relatively simple networks highlight the necessity of using theoretical approaches in understanding higher order biological functions. BioEssays 24:1110–1117, 2002. © 2002 Wiley‐Periodicals, Inc. (shrink)

A prevailing thought is that generics have a covert modal operator at logical form. I claim that if this is right, the covert generic modality is a weak necessity modal. In this paper, I pr...

The call of the wild -- A stranger in strange lands -- Song of myself -- Senses and sensibilities -- I, robot -- Lord of the things -- And then there were none.

We have considered a simple word game called the word-morph. After making our participants play a stipulated number of word-morph games, we have analyzed the experimental data. We have given a detailed analysis of the learning involved in solving this word game. We propose that people are inclined to learn landmarks when they are asked to navigate from a source to a destination. We note that these landmarks are nodes that have high closeness-centrality ranking.

Libertarians are an increasingly prominent ideological group in U.S. politics, yet they have been largely unstudied. Across 16 measures in a large web-based sample that included 11,994 self-identified libertarians, we sought to understand the moral and psychological characteristics of self-described libertarians. Based on an intuitionist view of moral judgment, we focused on the underlying affective and cognitive dispositions that accompany this unique worldview. Compared to self-identified liberals and conservatives, libertarians showed 1) stronger endorsement of individual liberty as their foremost guiding (...) principle, and weaker endorsement of all other moral principles; 2) a relatively cerebral as opposed to emotional cognitive style; and 3) lower interdependence and social relatedness. As predicted by intuitionist theories concerning the origins of moral reasoning, libertarian values showed convergent relationships with libertarian emotional dispositions and social preferences. Our findings add to a growing recognition of the role of personality differences in the organization of political attitudes. (shrink)

We developed an on-line intelligent argumentation system which facilitates stakeholders in exchanging dialogues. It provides decision support by capturing stakeholders’ rationale through arguments. As part of the argumentation process, stakeholders tend to both polarise their opinions and form polarisation groups. The challenging issue of assessing argumentation polarisation had not been addressed in argumentation systems until recently. Arvapally, Liu, and Jiang [, ‘Identification of Faction Groups and Leaders in Web-Based Intelligent Argumentation System for Collaborative Decision Support’, in Proceedings of International Conference (...) on Collaborative Technologies and Systems] earlier developed a method to identify polarisation groups. These groups, however, tend to overlap to a certain degree; each stakeholder may be a member of multiple polarisation groups to varied degrees. Quantifying stakeholders’ membership in multiple polarisation groups is an important issue in the argumentation for collaborative decision-making, which is not addressed earlier. We present a novel approach using fuzzy clustering algorithm to address this issue in this article. The method is evaluated using data sets produced from the discussions of 24 stakeholders. Experimental results indicate that our method is effective for both identifying polarisation groups and quantifying stakeholders’ degree of membership in each polarisation group. (shrink)

Individualized customer information is at the heart of on-line commerce. Using increasing amounts of customer-specific data enhances the success and value of one-to-one on-line marketing; but the extensive gathering and use of data specific to individuals also causes alarm over the loss of digital privacy, setting up a confrontation between e-commerce and society. Governments and nations, particularly in Europe, have reacted with a reliance on sweeping laws governing digital privacy protection while other nations such as the U.S. have generally preferred (...) to allow companies and industry associations to regulate themselves. This tenuous balance is under attack from both sides. In this paper, we set up a framework which incorporates the environmental context, ethical perspectives and firm-specific considerations to help firms develop a strategy for handling digital privacy concerns. (shrink)

A new translation of: The yoga sutras of Patanjali, the ancient Indian text which sets forth the practical and philosophical foundations of yoga, presented here with extensive commentary and spiritual exercises to assist in the practice and understanding of one's own spiritual search"--Provided by publisher.

I argue that moral principles involve the same sort of generalization as ordinary yet elusive generic generalizations in natural language such as 'Tigers are striped' or 'Peppers are spicy'. A notable advantage of the generic view is that it simultaneously allows for pessimism and optimism about the role and status of moral principles in our lives. It provides a new perspective on the nature of moral principles on which principles are not apt for determining the moral status of particular actions (...) while they may be apt, and even fundamental, to our acquisition of moral knowledge. A natural consequence of the view is variation amongst moral principles, with some regularly warranting exceptions, and some appearing arguably exceptionless. It is also argued that this generic conception of moral principles has significant advantages, as a normative model of moral reasoning, over the view of moral principles as defaults advanced in recent years. (shrink)

A vibrant example of living literature, the Bhagavata Purana is a versatile Hindu sacred text written in Sanskrit verse. Finding its present form by the tenth century C.E., the work inspired several major north Indian devotional (bhakti) traditions as well as schools of dance and drama, and continues to permeate popular Hindu art and ritual in both India and the diaspora. Introducing the Bhagavata Purana's key themes while also examining its extensive influence on Hindu thought and practice, this collection conducts (...) the first multidimensional reading of the entire text. Each essay focuses on a key theme of the Bhagavata Purana and its subsequent presence in Hindu theology, performing arts, ritual recitation, and commentary. The authors consider the relationship between the sacred text and the divine image, the text's metaphysical and cosmological underpinnings, its shaping of Indian culture, and its ongoing relevance to contemporary Indian concerns. (shrink)

Rather than a hatha how-to guide with asanas and step-by-step instructions, The Spiritual Roots of Yoga explains yoga’s origin and underlying philosophy. The book dives straight to the heart of the yogic tradition embodied in the figure of Krishna in the Bhagavad Gita, an understanding broadened through an examination of Patanjali’s Yoga Sutra. It then provides the framework for an accessible comparison between yoga and Christian, Buddhist, and other systems of thought. The author of several acclaimed interfaith studies, Ravi (...) Ravindra writes from a deep understanding of not only the philosophy but the context from which yoga evolved, as well as its standing within the community of religious thought and practice, offering practitioners and other spiritual pilgrims a deeper appreciation of the tradition. (shrink)

How people think about poverty is shown to be dependent on how the issue is framed..

In Xenophon’s Socratic literature, there is repeated emphasis on the utility the friends provide one another. One extended passage, _Memorabilia_ 2.6, shows that Socrates takes a good person to care about a friend both for the benefits to be gained for oneself and for the sake of the other’s welfare. Genuine friendship, for Socrates, is not transactional or self-interested but rather rooted in the mutual benefit that only good people can provide one another.

The spread of digital technology to all parts of our lives has led to meaningful benefits, ranging from the conveniences offered by ride-sharing apps to prediction of mental health crises and track...

Iyengar Yoga Wisdom & Practice" is a practical and an inspiring anthology of Iyengar's insights into yoga, life and the path to peace and happiness. Yoga practice lies at the heart of the book, and it is illustrated with over 60 new step-by-step sequences of yoga postures specially shot in India and accompanied by Iyengar's illuminating observations on technique, their significance, and their benefits. This book not only presents Iyengar's practical advice on how to perform key (...) yoga postures, but also draws on a wide range of other material taken from interviews and world lecture tours, to the many texts Iyengar has written about yoga and about his own life's journey. (shrink)

_Curriculum and Learning for Climate Action_ offers researchers, practitioners, donors, and decisionmakers insights into entry points for education systems change needed to reorient human society’s relationship with our planetary systems.

The dissertation analyzes the ontological and epistemological arguments that motivate Plato's theory of Forms.

Since the end of the Second World War, the Australasian economies have fared poorly relative both to the high-income states of western Europe and North America and to the `miracle' economies strung along the Pacific coasts of Asia. This article attempts to analyze the post-war trajectories of antipodean economies in the context of the reconstruction of the world market under US hegemony after the end of the Second World War. The first section traces the rise of Japan and the emergence (...) of Pacific Asia as a consolidated nexus of densely interwoven patterns of relational networks. The second section examines how ongoing processes of capitalist restructuring undermined the Asian miracle economies. Finally, the last section seeks to analyze the causes for the disproportionately adverse impact that processes of worldwide transformation have had for the two antipodean settler states. (shrink)

The “class play” is an annual tradition in residency training programs and medical schools that celebrates the end of the academic year. It is also a locally generated narrative that reveals important components of an institution’s values, culture, and group dynamics. Exploring the class play is a reflexive exercise that allows one to reflect on his or her professional development and place in the department in a structural, historical, and experience-near driven way. In this way, the creation of and examining (...) of the class play may be seen as an opportunity to understand and expand upon medicine’s Hidden Curriculum. (shrink)

The practice of paying prisoners to for their participation in research has long been debated, and the controversy is reflected in the differing policies in the U.S. prison systems. Empirical study of financial payments to inmates who enroll in research has focused on whether this practice is coercive. In this study, we examined whether monetary incentives have the potential to be unduly influential among fifty HIV‐positive prisoners. The majority of prisoners surveyed believed that inmates should receive some compensation for their (...) involvement in research and disagreed with statements suggesting that the offer of payment constitutes undue influence. However, a sense of potentially being susceptible to undue influence was significantly higher among participants who had spent a longer time in prison and had less education. Overall, our findings suggest that most prisoners feel that they would be able to make a decision about research enrollment that is not solely based on an offer of monetary payment. (shrink)

The attitude that ordinary language description of experience is in fact a description of the world is called “naïve realism.” There is an entire branch of modern Western philosophy that is devoted to critically examining the assumptions behind the everyday language we use to describe the macroscopic world in which we live and the validity of naïve realism as an adequate description of the world. This branch of philosophy is called “ordinary language philosophy.” Surprisingly, it has something in common with (...) quantum physics: insight into the inadequacy of ordinary language to describe observable reality. It is this connection between ordinary language philosophy and quantum physics that we shall explore in this article. In the process, we shall also offer a basic introduction to both basic philosophy and basic quantum theory. (shrink)

The target article's climato-economic theory will benefit by allowing for bidirectional effects and the heterogeneity of types of freedom, in order to more fully capture the coevolution of societal wealth and freedom. We also suggest alternative methods of testing climato-economic theory, such as longitudinal analyses of these countries' histories and micro-level experiments of each of the theory's hypotheses.

"The definitive work by B.K.S. Iyengar, the world's most respected yoga teacher. B.K.S. Iyengar has devoted his life to the practice and study of yoga. It was B.K.S. Iyengar's unique teaching style, bringing precision and clarity to the practice, as well as a mindset of 'yoga for all', which has made it into the worldwide phenomenon it is today. 'Light on Yoga' is widely called 'the bible of yoga' and has served as the source book for generations (...) of yoga students around the world. It is the classic text for all serious students of yoga." --Publisher description. (shrink)

Kevin Dorst has recently pointed out an apparently puzzling consequence of denying epistemic luminosity: given some natural-sounding bridging principles between knowledge, credence, and indicative conditionals, the denial of epistemic luminosity licenses the knowledge and assertability of abominable-sounding conditionals of the form ⌜If I don’t know that ϕ, then ϕ⌝. We provide a general and systematic examination of this datum by testing Dorst’s claim against various semantics for the indicative conditional in the setting of epistemic logic. Our conclusion is that, regardless (...) of whether knowledge is luminous, the knowability of these conditionals is highly sensitive to the correct semantic analysis of the indicative conditional. Moreover, standard pragmatic resources can explain away the infelicity of such assertions. As it stands, the datum does not tell against epistemic non-luminosity. (shrink)

With its Vedāntic metaphysics and devotionally rich narratives, the Bhāgavata Purāṇa can provide valuable models for ecological care and preservation. Throughout the Purāṇa, we find narratives that can be harnessed in service of the environment, whether it be Kṛṣṇa battling the serpent Kāliya or Varāha lifting the Earth from the depths of the cosmic ocean. This article, however, will focus on a little-known narrative found in Book Four, namely, the Pracetās’ destruction, and eventual protection, of the Earth’s trees. The Pracetās’ (...) narrative is significant for several reasons: instead of simply venerating nature, the story demonstrates the challenge of balancing human needs and the needs of other life forms; it accords agency to the Earth by giving the forest a voice within the narrative; and it bridges the boundary between human beings and the natural world by building kinship relationships between them. This article will explore the ways in which Vaiṣṇava commentators have interpreted this episode as they attempt to negotiate the question: who has priority—humans or nature? (shrink)

Formalized by the tenth century, the expansive Bhāgavata Purāṇa resists easy categorization. While the narrative holds together as a coherent literary work, its language and expression compete with the best of Sanskrit poetry. The text's theological message focuses on devotion to Krishna or Vishnu, and its philosophical outlook is grounded in the classical traditions of Vedānta and Sāmkhya. This translation and detailed analysis of the Bhāgavata Purāṇa includes endnotes that explain unfamiliar concepts and essays that elucidate the rich debates found (...) in the Sanskrit commentaries. The book makes a central Hindu masterpiece more accessible to English-speaking audiences and more meaningful to scholars of Indian literature, philosophy, and religion. (shrink)

The Copenhagen interpretation, which informs the textbook presentation of quantum mechanics, depends fundamentally on the notion of ontological wave-particle duality and a viewpoint called “complementarity.” In this paper, Bohr's own interpretation is traced in detail and is shown to be fundamentally different from and even opposed to the Copenhagen interpretation in virtually all its particulars. In particular, Bohr's interpretation avoids the ad hoc postulate of wave function ‘collapse' that is central to the Copenhagen interpretation. The strengths and weakness of both (...) interpretations are summarized. ‡I thank Edward Mackinnon, Henry Folse, and Greg Anderson for valuable comments on the penultimate draft. The final responsibility for the paper rests with the author. †To contact the author, please write to: Bhaktivedanta Institute, 2334 Stuart Street, Berkeley, CA; e-mail: [email protected]. I have been unable to achieve a sharp formulation of Bohr's principle of complementarity despite much effort I have expended on it. (Einstein 1949, 674) While imagining that I understand the position of Einstein, as regards the EPR correlations, I have very little understanding of his principal opponent, Bohr. (Bell 1987, 155) Niels Bohr brain-washed a generation of physicists into believing that the problem had been solved fifty years ago. (Gell-Mann 1979, 29) Every sentence I say must be understood not as an affirmation, but as a question. (Niels Bohr, quoted in Jammer 1966, 175) Bohr's interpretation has never been fully clarified. It needs an interpretation itself, and only that will be its defense. (Weizsäcker 1971, 25). (shrink)

Subjectivity or the problem of ‘qualia’ tends to make the accessibility and comprehension of psychological events intangible especially for scientific exploration. The issue becomes even more complicated but interesting when one turns towards mystical experiences. Such experiences are different from other psychological phenomena in the sense that they don’t occur to every one, so are difficult to comprehend even for their qualifications of existence. We conducted a qualitative study on one such experience of inner-light perception. This is a common experience (...) reported by meditators of all kinds. However, we chose to study this phenomenon in Vihangam Yoga practitioners because of frequent occurrence of this experience in them as well as their reports of having it for hours at a stretch. During this study, it was noted that it arose many questions there we need to answer not only to explain such phenomena but also for having a better understanding of philosophy of science. In the search for these answers, we proceeded towards another complicated branch of science, quantum mechanics. Our present work is about creating an interface between a unique subjective phenomenon and principles of philosophy as well as of quantum mechanics. We explore the constructs of physical and critical realisms and their coincidence, quantum information theory and the measurement problem of Copenhagen interpretation and their possible applications in such an experience. In this endeavour, we also address the possibility that inner-light perception as experienced by Vihangam Yogis is a quantum event in brain. For this purpose, we specifically analyse the Zeilingers information concept and try to apply it to this phenomena. (shrink)