Urban streetscapes are outdoor areas in which the general public can appreciate green landscapes and engage in outdoor activities along the street. This study tested the extent to which the degree of awareness of urban street trees impacts attention restoration and perceived restorativeness. We manipulated the degree of awareness of street trees. Participants were placed into four groups and shown different images: (a) streetscapes with absolutely no trees; (b) streetscapes with flashes of trees in which participants had minimal awareness of (...) the content; (c) streetscapes with trees; and (d) streetscapes with trees to which participants were told to pay attention. We compared the performance of 138 individuals on measures of attention and their evaluations of perceived restorativeness. Two main findings emerged. First, streetscapes with trees improved the performance of participants on attentional tests even without their awareness of the trees. Second, participants who had raised awareness of street trees performed best on the attentional test and rated the streetscapes as being more restorative. These findings enhance our knowledge about the role of an individual's awareness of restorative elements and have implications for designers and individuals who are at risk of attentional fatigue. (shrink)

Attending cram school has long been a trend in ethnic Chinese culture areas, including Taiwan. Despite the fact that school reform policies have been implemented in Taiwan, cram schools have continued to prosper. Therefore, in this educational culture, how to achieve a good educational effect is also a topic worthy of discussion. However, whether students really engage in those tutoring programs provided by cram schools has seldom been studied. To address this gap, this study explored how parents’ hovering attitude toward (...) life and coursework influences their children’s engagement in cram schools. This study targeted those students who attend English cram schools to test the correlates between two types of helicopter parenting, tutoring engagement and continued attendance at cram schools. A total of 320 questionnaires were sent out, and 300 were returned, giving an overall response rate of 93.75%. Excluding seven incomplete or invalid questionnaires, 293 valid questionnaires were received. The results of this study show that hovering behavior awareness is negatively related to cram school engagement, whereas cram school engagement is positively related to the intention to continue attending cram school. Moreover, the results imply that parents should alleviate their helicoptering behavior to enhance their children’s engagement in cram school tutoring programs. (shrink)

Visual programming language is a crucial part of learning programming. On this basis, it is essential to use visual programming to lower the learning threshold for students to learn about artificial intelligence to meet current demands in higher education. Therefore, a 3-h AI course with an RGB-to-HSL learning task was implemented; the results of which were used to analyze university students from two different disciplines. Valid data were collected for 65 students in the Science -student group and 39 students in (...) the Humanities -student group. Independent sample t-tests were conducted to analyze the difference between cognitive styles and computational thinking. No significant differences in either cognitive style or computational thinking ability were found after the AI course, indicating that taking visual AI courses lowers the learning threshold for students and makes it possible for them to take more difficult AI courses, which in turn effectively helping them acquire AI knowledge, which is crucial for cultivating talent in the field of AI. (shrink)

This article explores intersections between critical theory, Buddhism, and film studies in what Jürgen Habermas characterizes as the current ‘post-secular society’. I use A...

Background: Healthcare workers in the front line of diagnosis, treatment, and care of patients with coronavirus disease 2019 are at great risk of both infection and developing mental health symptoms. This study aimed to investigate the following: whether healthcare workers in general hospitals experience higher mental distress than those in psychiatric hospitals; the role played by religion and alexithymic trait in influencing the mental health condition and perceived level of happiness of healthcare workers amidst the stress of the COVID-19 pandemic; (...) and factors that influence the resilience of healthcare workers at 6 weeks' follow-up.Methods: Four-hundred and fifty-eight healthcare workers were recruited from general and psychiatric hospitals, and 419 were followed-up after 6 weeks. All participants filled out the 20-item Toronto Alexithymia Scale, five-item Brief-Symptom Rating Scale, and the Chinese Oxford Happiness Questionnaire.Results: Under the stress of the COVID-19 pandemic, 12.3% of frontline healthcare workers in general hospitals reported having mental distress and perceived lower social adaptation status compared with those working in psychiatric hospitals. Christians/Catholics perceived better psychological well-being, and Buddhists/Taoists were less likely to experience mental distress. The results at 6 weeks of follow-up showed that the perceived lower social adaptation status of general hospital healthcare workers was temporary and improved with time. Christian/Catholic religion and time had independent positive effects on psychological well-being; however, the interaction of Christian/Catholic religion and time had a negative effect.Conclusions: Collectivism and individualism in the cultural context are discussed with regard to alexithymic trait and Buddhist/Taoist and Christian/Catholic religious faiths. Early identification of mental distress and interventions should be implemented to ensure a healthy and robust clinical workforce for the treatment and control of the COVID-19 pandemic. (shrink)

The effective controlling and monitoring of an industrial process through the integration of statistical process control and engineering process control has been widely addressed in recent years. However, because the mixture types of disturbances are often embedded in underlying processes, mixture control chart patterns are very difficult for an SPC-EPC process to identify. This can result in problems when attempting to determine the underlying root causes of process faults. Additionally, a large number of categories of disturbances may be present in (...) a process, but typical single-stage classifiers have difficulty in identifying large numbers of categories of disturbances in an SPC-EPC process. Therefore, we propose a two-stage neural network based scheme to enhance the accurate identification rate for MCCPs by performing dimension reduction on disturbance categories. The two-stage scheme includes a combination of a NN, support vector machine, and multivariate adaptive regression splines. Experimental results reveal that the proposed scheme achieves a satisfactory AIR for identifying MCCPs in an SPC-EPC system. (shrink)

Jürgen Renn examines the role of knowledge in global transformations going back to the dawn of civilization while providing vital perspectives on the complex challenges confronting us today in the Anthropocene--this new geological epoch shaped by humankind. Renn reframes the history of science and technology within a much broader history of knowledge, analyzing key episodes such as the evolution of writing, the emergence of science in the ancient world, the Scientific Revolution of early modernity, the globalization of knowledge, industrialization, and (...) the profound transformations wrought by modern science. He investigates the evolution of knowledge using an array of disciplines and methods, from cognitive science and experimental psychology to earth science and evolutionary biology. The result is an entirely new framework for understanding structural changes in systems of knowledge--and a bold new approach to the history and philosophy of science. (shrink)

This study attempts to examine the direct impact of corporate social responsibility initiatives on employees’ job performance and the indirect relationships between CSR initiatives on employees’ job performance via industrial relations climate and psychological contract fulfillment. Data were collected from 764 supervisor–subordinate dyads and 271 middle managers from 85 companies. Using a multilevel approach, the results showed that organizational-level CSR was positively related to employees’ job performance. Moreover, the industrial relations climate and psychological contract fulfillment played mediating effects between CSR (...) initiatives and job performance. This study provides novel theoretical evidence for why and how CSR initiatives improve job performance. Theoretical and practical implications for implementing CSR initiatives are discussed. (shrink)

Delineation of the subthalamic nuclei on MRI is critical for deep brain stimulation surgery in patients with Parkinson’s disease. We propose this retrospective cohort study for quantitative analysis of MR signal-to-noise ratio, contrast, and signal difference-to-noise ratio of the STN on pre-operative three-dimensional stereotactic MRI in patients with medication-refractory PD. Forty-five consecutive patients with medication-refractory PD who underwent STN-DBS surgery in our hospital from January 2018 to June 2021 were included in this study. All patients had whole-brain 3D MRI, including (...) T2-weighted imaging, T2-weighted fluid-attenuated inversion recovery, and susceptibility-weighted imaging, at 3.0 T scanner for stereotactic navigation. The signal intensities of the STN, corona radiata, and background noise were obtained after placing regions of interest on corresponding structures. Quantitative comparisons of SNR, contrast, and SDNR of the STN between MR pulse sequences, including the T2WI, FLAIR, and SWI. Subgroup analysis regarding patients’ sex, age, and duration of treatment. We used one-way repeated measures analysis of variance for quantitative comparisons of SNR, contrast, and SDNR of the STN between different MR pulse sequences, and we also used the dependent t-test for the post hoc tests. In addition, we used Mann–Whitney U test for subgroup analyses. Both the contrast and SDNR were highest on FLAIR. The SNR was highest on SWI, and both the SNR and SDNR were lowest on T2WI. Subgroup analyses demonstrated significantly lower SDNR on SWI for patients receiving medication treatment for ≥13 years. In conclusion, on 3D stereotactic MRI of medication-refractory PD patients, the contrast and SDNR for the STN are highest on FLAIR, suggesting the optimal delineation of STN on FLAIR. (shrink)

This book focuses on the ritualized forms of mobility that constitute phenomena of pilgrimage in South Asia and establishes a new analytical framework for the study of ritual journeys. The book advances the conceptual scope of 'classical' Pilgrimage Studies and provides empirical depth through individual case studies. A key concern is the strategies of ritualization through which actors create, assemble and (re-)articulate certain modes of displacement to differentiate themselves from everyday forms of locomotion. Ritual journeys are understood as being both (...) productive of and produced by South Asia's socio-economically uneven, politically charged and culturally variegated landscapes. From various disciplinary angles, each chapter explores how spaces and movements in space are continually created, contested and transformed through ritual journeys. By focusing on this co-production of space and mobility, the book delivers a conceptually driven and empirically grounded engagement with the diverse and changing traditions of ritual journeying in South Asia. Interdisciplinary in its approach, the book is a must-have reference work for academics interested in South Asian Studies, Religious Studies, Anthropology and Human Geography with a focus on pilgrimage and the socio-spatial ideas and practices of ritualized movements in South Asia. (shrink)

Concept of change in Indic philosophy, with reference to Buddhism.

The term ‘publicness’ is a keyword to explain the creation of a people in the history of modern education in Korea in which the relationship between the ruled and the ruling power rapidly changed from the perspective of continuity and discontinuity. In Korea, the term has been commonly used in three different contexts, and its meanings have changed since the 1894 Gabo Reform, the first reform for the modernization of Korea. Even when the ruling power changed in 1910 with Japanese (...) colonialism, the ruling class took the meaning of publicness as a governing institution, which had a very weak sense of publicness as an ethical principle of fairness or as public benefit and opinion. In contrast, the resisting power, which was fully established throughout the colonial era from 1910 to 1945, lacked the sense of publicness as a ruling institution, but embraced the two other concepts of publicness. This historical experience of the competing concepts of publicness materialized into the creation of a modern people through law and education even in the post-colonial period of modern Korea. Generally speaking though, the creation of a modern people in Korea has been strongly affected by the concept of publicness as a ruling institution through a nationalist education. (shrink)

The Moksopaya is a work with the extent of 30.000 double verses of a Kashmirian anonym from themiddle of the 10th Century. Established without referring to traditional authority it presents a unique cosmography in the Indian history of ideas. Before the discovery of the Kashmirian version, in which the original hides itself, this philosophical piece of literature was only known in India and Europe in a later version that was tendentiously changed by several insertions. While the work on the complete (...) edition of the oldest version at the University of Halle- Wittenberg is still in progress, this volume includes some of the results from the project:- a detailed description of the narration of the queen Lila- a study on the fundamental philosophical ideas- an analysis of the text history and the versions- studies on the construction and dating- studies on the double nature of the work as poetry and philosophical paper - on its social and religious context. (shrink)

In this bold, provocative account, the author argues that the phenomena of life and mind elude purely materialistic explanations. Living matter occupies a unique phase of existence which results from the complex transformation of its biochemical synergies. Analogous phase changes account for mind and self-reflexive consciousness. A central role in the living state is played by intelligence, which has not been recognised as a non-negotiable precondition of organic existence. Yet the concept of evolutionary adaptivity relies tacitly on it. Thus the (...) book amounts to a serious challenge to the overly theoretical paradigmata of the last half-century with their timorous evasion of biological fundamentals. However, although the work relies on up-to-date research of the life sciences, it is a primarily philosophical enquiry, dealing head on with many unsolved problems of life and mind, and culminating in a detailed "ontological proof" of the mind system. (shrink)

I aim to provide a satisfying response to radical scepticism, a view according to which our knowledge of the external world is impossible. In the first chapter I investigate into the nature and the source of scepticism. Radical scepticism is motivated both by the closureRK-based and the underdeterminationRK-based sceptical arguments. Because these two sceptical arguments are logically independent, any satisfying anti-sceptical proposal must take both of them into consideration. Also, scepticism is a paradox, albeit a spurious one, so we need (...) to provide a diagnosis as to why we are lead into the paradox and why the alleged paradox misrepresents our epistemic standings. Hence, I advocate an obstacle-dissolving strategy for combating the sceptical problem. In chapter two, I discuss the anti-sceptical import of transcendental arguments. Although ambitious transcendental arguments are vulnerable to Stroud’s dilemma, I argue that modest transcendental arguments are promising. Modest transcendental arguments start from an undoubted psychological fact and then reveal some necessary theoretical commitments that we must make. Regarding these commitments, I submit that we are type II epistemically justified in believing them. Our commitments are type II justified in the sense that making these commitments can promote our epistemic goals, namely, the attainment of true beliefs and the avoidance of false beliefs. After that, in light of Cassam’s objection to transcendental arguments, I contend that a modest transcendental argument should be used as a stepping stone for a diagnostic anti-sceptical proposal. In chapter three, I develop a Davidsonian response to closureRK-based radical scepticism. This form of sceptical argument rests on the idea that there is no limitation on our acquisition of rationally grounded knowledge. I discuss Davidson’s theory of radical interpretation, the principle of charity and triangulation. Crucially, he argues that the content of a knowledge-apt everyday belief is determined by its typical cause and other relevant beliefs. Further, among different propositional attitudes, belief is prior to doubt. What follows is that doubt must be local because it must presume other content-determining beliefs. Also, I explore Davidson’s view on the concept of belief. On his view, in order to have a knowledge-apt belief, we must have the concept of knowledge-apt belief. We can command this concept by having the concept of objective truth. Objective truth requires that we are aware of and are capable of appreciating the possibility of a belief’s being true or false. And this possibility cannot be appreciated unless we have some related contentful beliefs to identify the content of the very belief. However, we are committed to, as opposed to believing, the proposition that the sceptical hypothesis does not obtain. It is impossible to appreciate the possibility of our fundamental commitments being false from our own perspective, because fundamental commitments specify the general cause of our beliefs. A change in this regard would cause a total change of the content of all beliefs, which leaves us no contentful belief at all to make this possibility intelligible. Therefore, the closureRK principle is not applicable to the evaluation of the sceptical hypothesis. Hence, we can retain the closureRK principle while evading the closureRK-based sceptical challenge. Unfortunately, the Davidsonian response cannot deal with the underdeterminationRK-based sceptical challenge, because we are not shown whether our rational support in the good case favours one’s everyday belief over its sceptical counterpart. In chapter four, I examine how epistemological disjunctivism can deal with underdeterminationRK-based radical scepticism. This form of sceptical argument assumes that our rational support provides at best inconclusive support for our beliefs. Therefore, a belief’s being rationally supported, no matter in the good case or in the bad case, is compatible with the belief’s being false. Epistemological disjunctivism claims that in paradigm cases of perceptual knowledge, our rational support can be both factive and reflectively accessible. The factive rational support at issue is one’s propositional seeing. I discuss both McDowell’s and Pritchard’s proposals for motivating factive seeing, and I argue for epistemological disjunctivism against three prime facie objections, i.e., the distinguishability problem, the basis problem and the access problem. When epistemological disjunctivism is shown to be a plausible view, I argue that underdeterminationRK-based radical scepticism can be dismissed. In particular, in the optimal case, factive rational support favours our everyday belief over the sceptical hypothesis. However, regarding closureRK-based radical scepticism, epistemological disjunctivism seems to licence a robust answer. The ambitious answer is that, in the good case, we can after all know the denial of the sceptical hypothesis in virtue of possessing factive rational support. And it is the immodesty of this answer that renders this response unpalatable. In the last chapter, I propose a combined treatment of the sceptical problem. Although both the Davidsonian response and the epistemological disjunctivist response can only deal with one aspect of the sceptical problem, their views are in fact mutually supportive. On the one hand, the Davidsonian response, together with a Wittgensteinian insight, shows that why rational support can only be provided in a local manner; on the other hand, epistemological disjunctivism reminds us that rational support can be factive in the good case. Putting these two points together allows us to answer the whole sceptical challenge in a uniform way. This combined proposal has three claims. First, our rational support can be both local and factive, so we can dismiss both sceptical arguments in one go. Second, the sceptical problem is a spurious paradox, so the combined treatment involves a diagnosis. This diagnosis starts from a modest transcendental argument which reveals some necessary commitments that we must make, and then proceeds to expose faulty assumptions in the sceptical paradox. Third, once the dubious assumptions are dislodged, we can evade the sceptical problem once and for all. In the end, we are offered with a satisfying response to radical scepticism. (shrink)

Thе article deals with the attitude of medical university students towards gender identification. The problem is extremely urgent because of dynamic change of the world. It has a politematic framework and addresses national features, religious and philosophical aspects, as well as many others. Tolerance issues in general and in certain areas of medicine in particular occupy an important place in the formation of a doctor as a professional. In the publication, a thorough analysis of the materials was carried out, which (...) makes it possible to speak about the discursivity of polo-gender topics. The results of the study made it possible not only to assess the ratio of the concepts of norm and pathology of sexual behavior among medical students, but also to identify the level of interest in this problem. (shrink)

Modernism in British arts, literature and philosophy is manifest as a unique thing around and after 1900. This paradigm shift in all arts and modern science made traditional beliefs, norms, and social patterns obsolete. Forerunners were 19th century intellectuals, who favoured a new and lively spiritual culture. A new concept of reality changed the view of nature (atomic physics) but also structure and gist of literature. As the belief in the visible world declined, consciousness and symbolism (surface and depth structures) (...) occupied the focus of attention. Literature became an autonomous field. From artistic subjectivity modernism led the way to crystallizing creation of complex imaginative structures. Simultaneously, neorealism in philosophy and relativity in physics substituted a worn-out mechanistic world picture by a scientific reality reaching far beyond the visible world. (shrink)

Imperatives occur ubiquitously in natural languages. They produce forces which change the addressee’s cognitive state and regulate her actions accordingly. In real life we often receive conflicting orders, typically, issued by various authorities with different ranks. A new update semantics is proposed in this paper to formalize this idea. The general properties of this semantics, as well as its background ideas are discussed extensively. In addition, we compare our framework with other approaches of deontic logics in the context of normative (...) conflicts. (shrink)

Tailoring workshop, a school-based teacher training program, has been developed in China on the basis of the Teaching Research Groups to better focus on teacher’s genuine needs, improve their problem-solving ability, and inter-subject collaboration. Literature on teacher workshops predominately roots in western settings whereas scant attention has been paid to those in Asian contexts, especially China. Therefore, a qualitative method was performed with teachers from a middle school in Shanghai to unveil how the TWs were formed, conducted, and how they (...) functioned effectively. Drawing on Dewey’s pragmatic theory as the analysis framework, the findings yielded a formation process with four stages and examined the mechanisms in four dimensions, namely, dynamics mechanism, organizational structure, role of teachers, and learning mechanism. The study argues that, the TWs prioritize teacher’s genuine needs and problems encountered in practice, encourage teachers to identify problems, seek resources and conduct research with collective wisdom for resolutions. These features make it significantly different from the traditional TRGs with ‘top-down’ approach and other training programs in reliance upon short-lived, external lectures. The TW mode, in this sense, can be deemed a promising endeavor to facilitate teacher’s sustainable development in echoing the ever-changing education domain. (shrink)

Using the dual-route reading model as a framework, this study investigated the following research questions on Hangul reading: Which orthographic units influence the reading performance of Korean-speaking children? In addition, do the influential units change as the children grow up? To answer these questions, we tested the effects of age, frequency, lexicality, and two types of length—the numbers of letters and syllable blocks —and the interactions of these factors in the reading performance of Korean-speaking preschool and primary school children from (...) first to third grade. Regarding reading latencies, there was a significant three-way interaction of age × lexicality × length regardless of the type of length. This interaction indicated that, for words only, the interaction between age and length was significant. Accordingly, the length effect decreased as children’s age increased. When reading latencies for words were analyzed with a mixed-effect model consisting of three factors—age, frequency, and length—neither a main effect of syllable block length nor an interaction of syllable block length with age was significant. In contrast, the interaction of age × letter length in word reading latencies remained significant. The length effect was smaller as children’s age increased. In addition, the frequency effect was significant and interacted significantly with age. The frequency effect increased as children’s age increased. In conclusion, significant frequency effects indicate that Korean-speaking children use the lexical process in addition to the non-lexical process when reading Hangul words. Importantly, as children grow up, a larger orthographic unit, that is, words, is more strongly related to reading performance, whereas the influence of the smaller orthographic unit, that is, letters, decreases. (shrink)

We study the relationship between corporate social performance and financial performance by comparing the portfolio returns of firms with changes in corporate social responsibility (CSR) intensity. Using an extensive US sample from the MSCI ESG database, we find that improvement in the overall CSR is generally value enhancing. The relationship varies with CSR dimensions. More importantly, the relationship shifts differently for various CSR dimensions during the crisis period when trust in the society is low and financial resource is limited. Improvement (...) in environment, human rights, and product characteristics shows higher financial returns during the financial crisis period, whereas the value enhancement of improvement in employee relations is more pronounced during the non-crisis period. (shrink)

ABSTRACT The paper gives an analytical synopsis of the problem of developing medical ethics in the early half of the 1990s in China, as perceived by Chinese scholars and medical professionals interested in medical ethics. The views captured and analyzed here were expressed in one of the two major journals on medical ethics in China: Chinese Medical Ethics. The economic reform unleashed profound changes in Chinese society, including in the medical field, creating irregularities and improprieties in the profession. Furthermore, the (...) market reform also created new values that were in tension with existing values. In this transitional period, Chinese medical ethicists saw the need to rebuild medical morality for the new era. Using the code of conduct promulgated by the Chinese Ministry of Health in 1989 as a basis, assessment and e ducation aspects of the institutionalization of medical ethics are dis‐ cussed. In addition to institutional problems of institutionalising ethics, there are philosophical and methodological issues that are not easy to solve. After all, to institutionalize medical ethics is no easy task for a country as old and as big as China. Chinese medical ethicists seem ready to confront these difficulties in their effort to develop medical ethics in Reform China. (shrink)

ABSTRACTThe paper gives an analytical synopsis of the problem of developing medical ethics in the early half of the 1990s in China, as perceived by Chinese scholars and medical professionals interested in medical ethics. The views captured and analyzed here were expressed in one of the two major journals on medical ethics in China: Chinese Medical Ethics. The economic reform unleashed profound changes in Chinese society, including in the medical field, creating irregularities and improprieties in the profession. Furthermore, the market (...) reform also created new values that were in tension with existing values. In this transitional period, Chinese medical ethicists saw the need to rebuild medical morality for the new era. Using the code of conduct promulgated by the Chinese Ministry of Health in 1989 as a basis, assessment and e ducation aspects of the institutionalization of medical ethics are dis‐ cussed. In addition to institutional problems of institutionalising ethics, there are philosophical and methodological issues that are not easy to solve. After all, to institutionalize medical ethics is no easy task for a country as old and as big as China. Chinese medical ethicists seem ready to confront these difficulties in their effort to develop medical ethics in Reform China. (shrink)

As early as January of 1957, at the Peking University Symposium on the Problems of the History of Chinese Philosophy, Chang Tai-nien was already attacking with his glittering words.

We introduce a new operator, called rational evaluation, in belief change. The operator evaluates new information according to the agent’s core beliefs, and then exports the plausible part of the new information. It belongs to the decision module in belief change. We characterize rational evaluation by axiomatic postulates and propose two functional constructions for it, based on the well-known constructions of kernel sets and remainder sets, respectively. The main results of the paper are two representation theorems with respect to the (...) two functional constructions. We also compare and connect the evaluation operator with some related operators in belief revision, including contraction, set contraction, and prioritized multiple revision. (shrink)

This article advances the thesis that our values and beliefs about engineering critically impact the teaching of engineering ethics, and our representations and assumptions about engineering are, accordingly, ethical questions we must consider. To illustrate how in broader sociohistorical contexts, different understandings of engineering have shaped expectations of ethics, we provide a historical and contemporary review of the literature. Examining the significance of our thesis for teaching practice, we discuss three case studies of our teaching and critically reflect on how (...) our representation of engineering limited the breadth and depth of ethics. Considering that instruction seemingly unrelated to ethics, in fact, influences how engineering ethics is understood and taught, our conclusion calls for critical examination of our beliefs about engineering. This entails, among others, up-to-date knowledge about the changing values of our rapidly-developing engineering fields and how they raise social, ethical questions of engineering relevant specifically to our teaching situation. (shrink)

The model organism Saccharomyces cerevisiae is providing new insights into the molecular and cellular changes that are related to aging. The yeast protein Sir2p (Silent Information Regulator 2) is a histone deacetylase involved in transcriptional silencing and the control of genomic stability. Recent results have led to the identification of Sir2p as a crucial determinant of yeast life span. Dosage, intracellular localization, and activity of Sir2p all have important effects on yeast longevity. For instance, calorie restriction apparently increases yeast life (...) span by increasing Sir2p activity. Since Sir2p‐related proteins have been identified in many prokaryotic and eukaryotic organisms, the fundamental principles derived from the studies in yeast may prove valuable in directing our future research toward an understanding of the mechanisms of aging in higher eukaryotes. BioEssays 23:327–332, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

Evidence from invertebrate systems including Aplysia and Drosophila, as well as studies carried out with mammalian brain, suggests that Ca2+-sensitive adenylyl cyclases may be important for long-term synaptic changes and learning and memory. Furthermore, some forms of long-term potentiation (LTP) in the hippocampus elevate cyclic AMP (cAMP) signals, and activation of adenylyl cyclases and cAMP-dependent protein kinase may be required for late stages of LTP. We propose that long-term changes in neurons and at synapses may require synergism between the cAMP (...) and Ca2+ signal transduction systems which regulates transcription and synthesis of specific proteins required for long-term synaptic changes. During LTP, protein kinase C is activated and intraccllular Ca2+ increases. We hypothesize that the calmodulin (CaM)-regulated adenylyl cyclases may be activated during LTP because of increases in intracellular Ca2+, release of free CaM from neuromodulin, activation by protein kinase C, release of neurotransmitters, or a combination of these events. Synergistic activation of CaM-sensitive adenylyl cyclases may produce a robust or prolonged cAMP signal required for transcriptional control. Furthermore, the coupling of the Ca2+ and cAMP systems may provide positive feedback regulation of Ca2+ channels by cAMP-dependent protein kinase. (shrink)

With the acceleration of social transformation and “mediatization,” urban women’s parenting practices have become an important factor affecting the demographic structure and national development. The global COVID-19 pandemic has further contributed to the networking of social life and the creation of “Internet moms” who rely on the Internet for parenting interactions. Using a mixed-methods design, this paper conducted participant observation and in-depth interviews with 90 mothers from various industries born after 1980/1990 across multiple geographies in China to examine the impact (...) of urban women’s Internet practices on the psychology and practice of parenting during the COVID-19 pandemic, as well as how they were empowered by media technologies to practice motherhood and complete their role socialization through the sharing of parenting information, experiences, and actions. The purpose of this qualitative study was to investigate the changing impact of Internet-based parenting practices on Chinese urban women’s daily lives during the COVID-19 pandemic. Through the analysis of these influences, it was found that the whole society, including urban parenting groups, paid attention to self-expression and self-worth and further hoped to arouse society’s recognition, face up to the identity of “mother” and “female,” and give more attention and support to women. The study also found that, as interpersonal communication channels were hindered during the COVID-19 pandemic, the power of the Internet, represented by social media, has created a new platform for information empowerment, action mutual, and ideation of motherhood for urban women formerly bound to family and parenting matters. From individual, family, and individual parenting experiences to group, social, and shared scenarios, urban women are engaged in emotional and memory interactions, including motherhood-related expression, experiences, and collaboration. This shift from virtual to physical has reshaped their parenting view, helping them break through the confines of family experience and traditional customs in addition to providing psychological motivation to express their gender concepts, shape their self-image, construct gender power, and interpret intimate relationships, pushing them to become more reflective of the times, as well as more capable and authoritative. (shrink)