As early as January of 1957, at the Peking University Symposium on the Problems of the History of Chinese Philosophy, Chang Tai-nien was already attacking with his glittering words.

BackgroundThe therapeutic effect of deep brain stimulation (DBS) of the subthalamic nucleus (STN) for Parkinson's disease (PD) is related to the modulation of pathological neural activities, particularly the synchronization in the β band (13–35 Hz). However, whether the local β activity in the STN region can directly predict the stimulation outcome remains unclear.ObjectiveWe tested the hypothesis that low-β (13–20 Hz) and/or high-β (20–35 Hz) band activities recorded from the STN region can predict DBS efficacy.MethodsLocal field potentials (LFPs) were recorded in (...) 26 patients undergoing deep brain stimulation surgery in the subthalamic nucleus area. Recordings were made after the implantation of the DBS electrode prior to its connection to a stimulator. The maximum normalized powers in the theta (4–7 Hz), alpha (7–13 Hz), low-β (13–20 Hz), high-β (20–35 Hz), and low-γ (40–55 Hz) subbands in the postoperatively recorded LFP were correlated with the stimulation-induced improvement in contralateral tremor or bradykinesia–rigidity. The distance between the contact selected for stimulation and the contact with the maximum subband power was correlated with the stimulation efficacy. Following the identification of the potential predictors by the significant correlations, a multiple regression analysis was performed to evaluate their effect on the outcome.ResultsThe maximum high-β power was positively correlated with bradykinesia–rigidity improvement (rs = 0.549, p < 0.0001). The distance to the contact with maximum high-β power was negatively correlated with bradykinesia–rigidity improvement (rs = −0.452, p < 0.001). No significant correlation was observed with low-β power. The maximum high-β power and the distance to the contact with maximum high-β power were both significant predictors for bradykinesia–rigidity improvement in the multiple regression analysis, explaining 37.4% of the variance altogether. Tremor improvement was not significantly correlated with any frequency.ConclusionHigh-β oscillations, but not low-β oscillations, recorded from the STN region with the DBS lead can inform stimulation-induced improvement in contralateral bradykinesia–rigidity in patients with PD. High-β oscillations can help refine electrode targeting and inform contact selection for DBS therapy. (shrink)

Delineation of the subthalamic nuclei on MRI is critical for deep brain stimulation surgery in patients with Parkinson’s disease. We propose this retrospective cohort study for quantitative analysis of MR signal-to-noise ratio, contrast, and signal difference-to-noise ratio of the STN on pre-operative three-dimensional stereotactic MRI in patients with medication-refractory PD. Forty-five consecutive patients with medication-refractory PD who underwent STN-DBS surgery in our hospital from January 2018 to June 2021 were included in this study. All patients had whole-brain 3D MRI, including (...) T2-weighted imaging, T2-weighted fluid-attenuated inversion recovery, and susceptibility-weighted imaging, at 3.0 T scanner for stereotactic navigation. The signal intensities of the STN, corona radiata, and background noise were obtained after placing regions of interest on corresponding structures. Quantitative comparisons of SNR, contrast, and SDNR of the STN between MR pulse sequences, including the T2WI, FLAIR, and SWI. Subgroup analysis regarding patients’ sex, age, and duration of treatment. We used one-way repeated measures analysis of variance for quantitative comparisons of SNR, contrast, and SDNR of the STN between different MR pulse sequences, and we also used the dependent t-test for the post hoc tests. In addition, we used Mann–Whitney U test for subgroup analyses. Both the contrast and SDNR were highest on FLAIR. The SNR was highest on SWI, and both the SNR and SDNR were lowest on T2WI. Subgroup analyses demonstrated significantly lower SDNR on SWI for patients receiving medication treatment for ≥13 years. In conclusion, on 3D stereotactic MRI of medication-refractory PD patients, the contrast and SDNR for the STN are highest on FLAIR, suggesting the optimal delineation of STN on FLAIR. (shrink)

On the fundamentals of Buddhist doctrines; including explation of the karmic law of cause and effect with stories.

Rgyal ba rdo rje 'chaṅ yab yam gyi rnam thar rin chen gter mdzod -- Saṅs rgyas thams cad kyi rnam 'phrul Rje-btsan Ti-lo-pa'i rnam mgur -- Bde gśegs phag mo gru pa'i rnam thar -- Bram zc chen pos mdzad pa'i ṅoh ha bskor gsum blo gsal mgal brgyan -- Bka' yoṅ dag pa'i tshad ma źes bya ba mkha'i 'gro ma'i man ṅag -- Bya btaṅ stag rtse sku skye'i rtogs brjod med snaṅ chu zla'i zlos gar -- (...) 'Gu-ru rin-po-che'i rnam thar bstod pa dbyid kyi sgra dbyaṅs. (shrink)

For any inquiry into Tasan (茶山)'s philosophy, it is absolutely necessary to investigate its relationship with Neo-Confucianism. Out of the many notions of his philosophy, the Kung-fu theory (工夫論) is considered to be important. Therefore, the comparison between Chu-hui 's (朱熹) system of Neo-Confucianism and Tasan's theory on Kung-fu is expected to offer clues that help us understand Tasan's philosophy. The purpose of this paper is to investigate Tasan’s viewpoints on the notion of ‘having not yet arisen,’ especially (...) in regards to his issues of 'the mind, intelligence, consideration, and discretion (心知思慮),' as presented in his Kung-fu theory. Tasan insists that the statement that "The joy, anger, sorrow, and pleasure have not yet arisen." differs from the statement that "The mind, intelligence, consideration, and discretion (心知思慮) have not yet arisen." In this paper, the author will inquire into Tasan's assertions on the meaning, contents, subject, and significance of ‘the mind, intelligence, consideration, and discretion,’ which he emphasizes. In addition, the author will make clear that the above assertion is related to the following: 1) Tasan’s recognition of Cheon (天), 2) his assertion on the capability of the mind to make decisions by itself (心自主權), and 3) his emphasis on the actualization of morality. (shrink)

This book offers a rich introduction to Heidegger that reveals Poggeler's sound scholarship and philosophical criticism.

Students and teachers of Chinese history and philosophy will not want to miss Daniel Gardner's accessible translation of the teachings of Chu Hsi —a luminary of the Confucian tradition who dominated Chinese intellectual life for centuries. Homing in on a primary concern of our own time, Gardner focuses on Chu Hsi's passionate interest in education and its importance to individual development. For hundreds of years, every literate person in China was familiar with Chu Hsi's teachings. They informed the curricula of (...) private academies and public schools and became the basis of the state's prestigious civil service examinations. Nor was Chu's influence limited to China. In Korea and Japan as well, his teachings defined the terms of scholarly debate and served as the foundation for state ideology. Chu Hsi was convinced that through education anyone could learn to be fully moral and thus travel the road to sagehood. Throughout his life, he struggled with the philosophical questions underlying education: What should people learn? How should they go about learning? What enables them to learn? What are the aims and the effects of learning? Part One of _Learning to Be a Sage_ examines Chu Hsi's views on learning and how he arrived at them. Part Two presents a translation of the chapters devoted to learning in the _Conversations of Master Chu_. (shrink)

In this paper, we study the estimation of motion direction prediction for fast motion and propose a threshold-based human target detection algorithm using motion vectors and other data as human target feature information. The motion vectors are partitioned into regions by normalization to form a motion vector field, which is then preprocessed, and then the human body target is detected through its motion vector region block-temporal correlation to detect the human body motion target. The experimental results show that the algorithm (...) is effective in detecting human motion targets in videos with the camera relatively stationary. The algorithm predicts the human body position in the reference frame of the current frame in the video by forward mapping the motion vector of the current frame, then uses the motion vector direction angle histogram as a matching feature, and combines it with a region matching strategy to track the human body target in the predicted region, thus realizing the human body target tracking effect. The algorithm is experimentally proven to effectively track human motion targets in videos with relatively static backgrounds. To address the problem of sample diversity and lack of quantity in a multitarget tracking environment, a generative model based on the conditional variational self-encoder conditional generation of adversarial networks is proposed, and the performance of the generative model is verified using pedestrian reidentification and other datasets, and the experimental results show that the method can take advantage of the advantages of both models to improve the quality of the generated results. (shrink)

Die vorliegenden Bande folgen dem gefeierten Heidegger- und Hegelkenner Otto Poggeler in seinen Fragestellungen uber die Beziehung zwischen Philosophie und Poesie. In 36 Beitragen werden Funktion und Form der Philosophie, Asthetik und Politik im deutschen Idealismus, die Einheit von Denken und Poesie bei Heidegger und die philosophische Dimension der Poesie diskutiert. - Der erste Band behandelt die Moglichkeit von Philosophie nach der Entdeckung der Geschichtlichkeit von menschlichem Wissen durch die hermeneutische Philosophie. Der zweite Band fuhrt diese Diskussion fort und entwickelt (...) die Beziehung zwischen Poggeler und Heidegger und dessen Kommentatoren und Gegnern. Hier wird das Verhaltnis von Philosophie und Poesie auch aus Sicht der Kunst verhandelt. - Mit Beitragen u.a. von Gadamer, Apel, Siep, Tilliette, Dusing und Lucas bieten die Bande in ihrer Reichhaltigkeit geradezu ein philosophisches Forum zum Thema Asthetik. (shrink)