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  1.  64
    Indirect Targeting of Subthalamic Deep Brain Stimulation Guided by Stereotactic Computed Tomography and Microelectrode Recordings in Patients With Parkinson’s Disease.Po-Hsun Tu, Zhuo-Hao Liu, Chiung Chu Chen, Wey Yil Lin, Amy L. Bowes, Chin Song Lu & Shih-Tseng Lee - 2018 - Frontiers in Human Neuroscience 12.
  2.  57
    Subthalamic high-beta oscillation informs the outcome of deep brain stimulation in patients with Parkinson's disease.Po-Lin Chen, Yi-Chieh Chen, Po-Hsun Tu, Tzu-Chi Liu, Min-Chi Chen, Hau-Tieng Wu, Mun-Chun Yeap, Chih-Hua Yeh, Chin-Song Lu & Chiung-Chu Chen - 2022 - Frontiers in Human Neuroscience 16:958521.
    BackgroundThe therapeutic effect of deep brain stimulation (DBS) of the subthalamic nucleus (STN) for Parkinson's disease (PD) is related to the modulation of pathological neural activities, particularly the synchronization in the β band (13–35 Hz). However, whether the local β activity in the STN region can directly predict the stimulation outcome remains unclear.ObjectiveWe tested the hypothesis that low-β (13–20 Hz) and/or high-β (20–35 Hz) band activities recorded from the STN region can predict DBS efficacy.MethodsLocal field potentials (LFPs) were recorded in (...)
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    Quantitative Analysis for the Delineation of the Subthalamic Nuclei on Three-Dimensional Stereotactic MRI Before Deep Brain Stimulation Surgery for Medication-Refractory Parkinson’s Disease.Chun-Yu Su, Alex Mun-Ching Wong, Chih-Chen Chang, Po-Hsun Tu, Chiung Chu Chen & Chih-Hua Yeh - 2022 - Frontiers in Human Neuroscience 16.
    Delineation of the subthalamic nuclei on MRI is critical for deep brain stimulation surgery in patients with Parkinson’s disease. We propose this retrospective cohort study for quantitative analysis of MR signal-to-noise ratio, contrast, and signal difference-to-noise ratio of the STN on pre-operative three-dimensional stereotactic MRI in patients with medication-refractory PD. Forty-five consecutive patients with medication-refractory PD who underwent STN-DBS surgery in our hospital from January 2018 to June 2021 were included in this study. All patients had whole-brain 3D MRI, including (...)
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