BackgroundThe use of genetic test results in risk-rated insurance is a significant concern internationally, with many countries banning or restricting the use of genetic test results in underwriting. In Australia, life insurers’ use of genetic test results is legal and self-regulated by the insurance industry (Financial Services Council (FSC)). In 2018, an Australian Parliamentary Inquiry recommended that insurers’ use of genetic test results in underwriting should be prohibited. In 2019, the FSC introduced an industry self-regulated moratorium on the use of (...) genetic test results. In the absence of government oversight, it is critical that the impact, effectiveness and appropriateness of the moratorium is monitored. Here we describe the protocol of our government-funded research project, which will serve that critical function between 2020 and 2023.MethodsA realist evaluation framework was developed for the project, using a context-mechanism-outcome (CMO) approach, to systematically assess the impact of the moratorium for a range of stakeholders. Outcomes which need to be achieved for the moratorium to accomplish its intended aims were identified, and specific data collection measures methods were developed to gather the evidence from relevant stakeholder groups (consumers, health professionals, financial industry and genetic research community) to determine if aims are achieved. Results from each arm of the study will be analysed and published in peer-reviewed journals as they become available.DiscussionThe A-GLIMMER project will provide essential monitoring of the impact and effectiveness of the self-regulated insurance moratorium. On completion of the study (3 years) a Stakeholder Report will be compiled. The Stakeholder Report will synthesise the evidence gathered in each arm of the study and use the CMO framework to evaluate the extent to which each of the outcomes have been achieved, and make evidence-based recommendations to the Australian federal government, life insurance industry and other stakeholders. (shrink)

Little is known about young children's ability to talk about absent members of their social network. We analyzed the speech of four children from 2 to 5 years. References to absent caregivers were relatively frequent, even when children were 2 years old. Such references were often generated spontaneously rather than being repetitions of a name produced by the child's interlocutor. Children's comments about absent family members occasionally expressed concern about contact with them but were predominantly neutral or reflective. By implication, (...) children can maintain a representation of the various members of their social network from an early age, despite separation. (shrink)

Religion and spirituality (R/S) serve as coping mechanisms for circumstances that threaten people’s psychological well-being. However, using R/S inappropriately to deal with difficulties and problems in daily life may include the practice of Spiritual Bypass (SB). SB refers to avoiding addressing emotional problems and trauma, rather than healing and learning from them. On the other hand, coping strategies may be determined by the cultural context. This study aims to describe the presence of SB in individuals who may have experienced stressful (...) situations and to understand the influence of culture on SB by comparing SB in two culturally different groups. The sample consists of a total of 435 people, 262 of Honduran nationality and 173 of Spanish nationality. Both groups are approximately equivalent in age and gender. The degree of SB, stressful events, perception of social support and spiritual well-being are examined, respectively, through the Spiritual Bypass Scale, and specific items and subscales from the Social Readjustment Rating Scale, Multidimensional Scale of Perceived Social Support, and the Functional Assessment of Chronic Illness Therapy - Spiritual Wellbeing. The results showed a higher spiritual well-being and use of SB in the Honduran sample as compared to the Spanish sample, but similar social support and stressful events. Furthermore, some of the factors predicting SB were different between the two samples. While age and a greater number of R/S practices were important in both samples, for the Honduran sample the variables that best explained SB were being a Christian, having greater social support, fewer stressful events, and greater attendance at church or temple. For the Spanish sample, however, the variable that best explained SB was studying R/S texts. Therefore, SB must be understood within the culture in which it develops, since in different cultural contexts it appears to relate to differing factors. Thus, SB becomes a possible functional or dysfunctional coping strategy depending on the social context. (shrink)

Trust has been identified as an indicator within Social Quality theory. As an important component of social quality, trust has become increasingly important in modern society because literature suggests that trust in a number of democratic countries is declining. Modern technologies and specialties are often beyond the understanding of lay individuals and thus, the need for trusting relations between lay individuals and organizations/individuals has grown. The purpose of the study was to examine the extent to which Australians (dis)trust individuals and (...) organizations/institutions. A national postal survey was conducted with 1,044 respondents recruited using the electronic white pages directory. Findings from multivariate analyses suggest that income, age, sex, and health status are associated with trust in groups of individuals and trust in organizations/institutions. The findings highlight populations where trust needs to be (re)built. Future government policy and practice should utilize these findings as a means of facilitating social quality. (shrink)

This comprehensive, systematic survey of Luther's ethical thought and teaching clearly discusses all the major ethical issues that concerned Luther. Contemporary readers will be especially interested in what the Reformer has to say about the Christian's attitude toward secular society, toward the state, and toward war. The Ethics of Martin Luther offers scholars and nonspecialists alike a much-needed explanation of Luther's ideas. --.

Abstract3′ untranslated regions (3′ UTRs) of mRNAs have many functions, including mRNA processing and transport, translational regulation, and mRNA degradation and stability. These different functions require cis‐elements in 3′ UTRs that can be either sequence motifs or RNA structures. Here we review the role of secondary structures in the functioning of 3′ UTRs and discuss some of the trans‐acting factors that interact with these secondary structures in eukaryotic organisms. We propose potential participation of 3′‐UTR secondary structures in cytoplasmic polyadenylation in (...) the model organism Drosophila melanogaster. Because the secondary structures of 3′ UTRs are essential for post‐transcriptional regulation of gene expression, their disruption leads to a wide range of disorders, including cancer and cardiovascular diseases. Trans‐acting factors, such as STAU1 and nucleolin, which interact with 3′‐UTR secondary structures of target transcripts, influence the pathogenesis of neurodegenerative diseases and tumor metastasis, suggesting that they are possible therapeutic targets. (shrink)

L'actualité des Chiens de garde, nous aurions préféré ne pas en éprouver la robuste fraîcheur. Nous aurions aimé qu'un même côté de la barricade cessât de réunir penseurs de métier et bâtisseurs de ruines. Nous aurions voulu que la dissidence fût devenue à ce point contagieuse que l'invocation de Nizan au sursaut et à la résistance en parût presque inutile. Car nous continuons à vouloir un autre monde. L'entreprise nous dépasse? Notre insuffisance épuise notre persévérance? Souvenons-nous alors de ce passage (...) par lequel Sartre a résumé l'appel aux armes de son vieux camarade : "Il peut dire aux uns : vous mourez de modestie, osez désirer, soyez insatiables, ne rougissez pas de vouloir la lune : il nous la faut. Et aux autres : dirigez votre rage sur ceux qui l'ont provoquée, n'essayez pas d'échapper à votre mal, cherchez ses causes et cassez-les." Serge Hamili Extrait de la préface. (shrink)

In this work, Paul Weithman offers a fresh, rigorous and compelling interpretation of John Rawls' reasons for taking his so-called 'political turn'.

In a belief ascription like ‘Sam believes that Hesperus rises in the evening’, the complementizer ‘that’ is a device for referring to the sense of the embedded sentence. On this Fregean view, substitutivity of co‐referential terms need not preserve truth. This accounts for the opacity of propositional attitude ascriptions, while preserving what Davidson called semantic innocence.

The proposed account of causation, in terms of explanation, does not sleight the mind‐independence of causal relations. The relevant notion of explanation is objective, even if facts are taken to be abstract Fregean ‘modes of presenting’ events. Causation remains a natural, and often perceptible relation between spatiotemporal particulars. But we must resist empiricist conceptions of causation.

Cuando ahora las formas de hacer historia materializan una multiplicidad de grafías, y el giro reflexivo y el giro historiográfico nos permiten idear las historias de las teorías de la historia en una posibilidad más, en este ensayo se presenta un deseo, una promesa cuya llave de acceso precisa saber lo que pretende la locución arqueoescritura. Esbozos y trazas de la teoría de la historia en cuestión: ¿qué cabe esperar en las escrituras diferidas de la arqueoescritura? Escrituras equívocas en clave (...) derridiana de la teoría de la historia como historiografía. Una posibilidad imposible aplazada. Escrituras para examinar la metafísica de la presencia en la historiografía, conscientes de que no podrán formular una teoría de la historia en la única firma derridiana, porque lo real se resiste a ser domado e incorporado al impar filosófico derridiano. (shrink)

Nederlandse wijsbegeerte.--Fichte, Schelling, Hegel en hun kring.

I. Grundprobleme. 2. Aufl. 1898.--II. Das Weib. 1897.--III. Gut und Böse. 1900.

An updated version of Plato's Dialogues, this adaptation takes place in contemporary times and is set at Reed College in Portland, Oregon. Through the characters' central discussions of Creationist and Materialist theories of evolution, together with their moral and social implications and ramifications, the author defines philosophy and science. This fresh approach to complex philosophical subjects will be an interesting supplement to courses in philosophy.

[ Philosophy against the natural sciences: “Dogmatism” in the dispute about “scientific monism” after 1900].