In this essay Lee examines three questions:1) Is nuclear proliferation dangerous? Is it morally permissible for a state to acquire nuclear weapons? What are morally permissible actions for states trying to keep other states from acquiring nuclear weapons?

The world witnessed a major historical event in 1947 when subcontinent, which was governed as a one unit from Khyber to Burma since almost last one thousand years, partitioned by the ruling British Empire resulting into two states namely India and Pakistan. The major reason behind partition of the subcontinent was the religious and cultural differences between the Hindus and Muslims. This difference made them hostile towards each other and India having superiority in all aspects, compelled Pakistan to become a (...) security state right after its inception. To expand its superiority over the whole region, the Indian nuclear program started in 1944, even before its independence. India conducted first nuclear tests in 1974 and continued expanding its nuclear program. This forced Pakistan to work seriously on its nuclear program with a fast pace. India announced its formal entry to the nuclear weapons club in May 1998 with 5 nuclear tests at Pokhran, Pakistan, having nuclear capability at that time, replied back in merely two weeks with 6 nuclear tests and became the 7th nation in the world and first Islamic country to join the nuclear countries club. The lives of over a billion people are at mercy of the two nuclear powers state heads, especially India having an extremist government poses a serious threat to the peace of subcontinent which needs great attention especially from the global community otherwise a nuclear Armageddon could be expected. (shrink)

Nuclear weapons proliferation is at the top of the news these days. Most recent reports have focused on the nuclear efforts of Iran and North Korea, but they also typically warn that those two acute diplomatic headaches may merely be the harbingers of a much darker future. Indeed, foreign policy sages often claim that what worries them most is not the small arsenals that Tehran and Pyongyang could build for themselves, but rather the potential that their reckless (...) behavior could catalyze a process of runaway nuclear proliferation, international disorder, and, ultimately, nuclear war. (shrink)

This article draws on the conceptualisation of ‘discursive formation’ to examine the particular configuration of the ‘objects, subjects, concepts and strategies’ which constituted ‘nuclear proliferation’ between 2006 and 2012. While previous studies have mostly explored the discourse of nuclear proliferation through the analysis of newspaper texts, few have considered corpora from different sites or considered the changes, transformations and contradictions that take place when meanings are delocated from one site and relocated in another. Elements of poststructuralist (...) discourse theory, critical linguistics and corpus linguistics are brought together to consider how events were constructed within two corpora: UN Security Council resolutions and newspaper articles published in prominent UK and US broadsheets. WordSmith Tools was used to analyse word frequencies, statistical patterns of keywords, word collocation profiles and concordance patterns. Results indicate that the most salient lexical items refer to actors, strategic actions and technologies. As these constituents of nuclear proliferation are delocated from the political sphere and relocated in the public sphere, three discursive strategies unfold: personalisation, normalisation or exceptionalisation, and reification. (shrink)

DNA metabolic events such as replication, repair and recombination require the concerted action of several enzymes and cofactors. Nature has provided a set of proteins that support DNA polymerases in performing processive, accurate and rapid DNA synthesis. Two of them, the proliferating cell nuclear antigen and its adapter protein replication factor C, cooperate to form a moving platform that was initially thought of only as an anchor point for DNA polymerases δ and ε. It now appears that proliferating cell (...) nuclear antigen is also a communication point between a variety of important cellular processes including cell cycle control, DNA replication, nucleotide excision repair, post‐replication mismatch repair, base excision repair and at least one apoptotic pathway. The dynamic movement of proliferating cell nuclear antigen on and off the DNA renders this protein an ideal communicator for a variety of proteins that are essential for DNA metabolic events in eukaryotic cells. (shrink)

China, India, Brazil and other major Third World nations have long refused to sign the Nuclear Non‐proliferation Treaty. This position might at first sight appear to be without any question morally unjustified and even irrational. Yet their claim that the treaty is ‘discriminatory’ merits the serious attention which it has not received. Only if certain aspects of this claim are accepted by the nuclear weapons signatories does a moral and rational onus to sign become unquestionable.

In each decade of the nuclear age, philosophers have provided critical reflections on the nature, use, and consequences of nuclear weapons. Frequently, these reflections have addressed the morality of producing, testing, deploying, and using nuclear weapons. Already, these philosophical reflections have passed through four phases and are now entering a fifth phase. The first phase stretches from the atomic bombing of Hiroshima to the above ground nuclear tests at Bikini Atoll. From the initial use of atomic (...) weapons in 1945 to the testing of the hydrogen bomb in 1952, the United States held a virtual monopoly. (The Soviet Union tested its first atomic weapon in 1949, and the United States progressed not only to the development of the hydrogen bomb, but also to a miniaturization of nuclear weapons that spawned even more tactical nuclear weapons than the eventual strategic arsenals of the superpowers.) During the 1950s and 1960s, the second phase shifts to a focus on the above ground testing of the hydrogen bomb, as well as the post war tension between the United States and the Soviet Union. The third phase addresses increasing shifts during the 1970s and 1980s to counterforce weapons and nuclear war fighting strategies. The fourth phase responds to the dissolution of the Soviet Union in 1991 and to the problems of nuclear proliferation and nuclear deterrence in the post Cold War world, culminating with a critique of the renewal of Star Wars in 2001 under the guise of ballistic missile defense. The first decade of the twenty first century ushers in not only the purported “war against terrorism” by the United States, but also a broader and deeper philosophical response to the interconnections among violence, terrorism, and war. (shrink)

Political theorists had vigorous debates about nuclear weapons in the 1980s but have been largely silent about them recently. This article seeks to reopen those discussions. It evaluates the main justifications for nuclear proliferation since 1945: arguments from consistency, nationalism, democratic legitimacy, self-defense, peaceful effects, and supreme emergency. Most of these arguments are badly flawed, as are the arguments for retaining the nuclear arsenals of many of the established nuclear powers. Instead, this article proposes a (...) first cut at a stringent standard for judging the acquisition of strategic nuclear weapons, drawing on jus ad bellum and jus in bello principles. (shrink)

We are at a time when international law and the law of war are particularly important. The testing of nuclear weapons that is being used in the rhetoric surrounding threats of war is creating new fears and heightening current tensions. Richard Falk has for decades been an outspoken authority calling for nuclear disarmament and the enforcement of non-proliferation treaties. In this collection of essays, Falk examines the global threats to all humanity posed by nuclear weapons. He (...) is not satisfied with accepting arms control measures as a managerial stopgap to these threats and seeks no less than to move the world back from the nuclear precipice and towards denuclearization. Falk's essays reflect the wisdom and innovative thinking he has brought to his long career as a scholar and activist, as he reminds nuclear weapons states of their obligation under international law and moral imperative to seek nuclear disarmament. (shrink)

Given the apocalyptic nature of nuclear weapons, how can states establish an international order that ensures survival while allowing the weapons to be used in controlled ways to discourage great wars, and while allowing nuclear technology to diffuse for civil purposes? How can the possession of nuclear weapons by a few states be reconciled with their renunciation by the majority of states? Which political strategies can best deliver an international nuclear order that is effective, legitimate and (...) durable? These have been central questions in the nuclear age. This article suggests that the effort to construct such an order displayed the characteristics of an enlightenment project, with its emphasis on balance and rationality, the quest for justice and trust among states, the feasibility of instrumental regulation, and the attachment to hope and progress. With the Nuclear Non-Proliferation Treaty at its heart, it necessarily gave precedence to diplomacy and containment over preventive war. The reasons why this conception of nuclear order was discarded by its erstwhile champion, the United States, in favor of one bearing traits of counter-enlightenment, are explored. Its alternative strategy can now be declared a failure. Avoidance of a greater disorder depends on recognition that the problem of nuclear order is more than the problem of proliferation, or of non-compliance, and on recovery whatever the difficulties of the cooperative yet pragmatic sensibility that lay behind the prior approach to order. (shrink)

Scott Sagan asked me to revisit Nuclear Ethics, a book I published in 1986, in light of current developments in world affairs. In doing so, I found that much had changed but the basic usability paradox of nuclear deterrence remains the same. As do the ethical dilemmas. To deter, there must be some prospect of use, but easy usability could produce highly immoral consequences. Some risk is unavoidable and the moral task is how best to lower it. (...) class='Hi'>Nuclear weapons pose moral problems but nuclear use is the greater evil. Abolition may be a worthy long-term goal, but it is unlikely in the short-term relations among the nine states now possessing nuclear weapons. Drawing on just war theory, I examine the three dimensions of intentions, means, and consequences to outline a ten-point agenda for just deterrence that seeks to lower risks of nuclear war. The world has changed since the book was published but the basic moral dilemmas remain the same. (shrink)

This article presents a plan of action to begin the process of halting proliferation of long-range ballistic missiles. These missiles are deemed particularly dangerous due to their ability to deliver weapons of mass destruction (nuclear, biological, and chemical warheads) over intercontinental distances. Two treaties are proposed to help control the proliferation of these missiles. They are a Ballistic Missile Non-Proliferation Treaty and a Test Ban Treaty for Long-Range Ballistic Missiles. Provision is made for peaceful launches of (...) satellites and space missions. (shrink)

In recent years, there has been an intense public debate about whether and, if so, to what extent investments in nuclear energy should be part of strategies to mitigate climate change. Here, we address this question from an ethical perspective, evaluating different strategies of energy system development in terms of three ethical criteria, which will differentially appeal to proponents of different normative ethical frameworks. Starting from a standard analysis of climate change as arising from an intergenerational collective action problem, (...) we evaluate whether contributions from nuclear energy will, on expectation, increase the likelihood of successfully phasing out fossil fuels in time to avert dangerous global warming. For many socio-economic and geographic contexts, our review of the energy system modeling literature suggests the answer to this question is “yes.” We conclude that, from the point of view of climate change mitigation, investments in nuclear energy as part of a broader energy portfolio will be ethically required to minimize the risks of decarbonization failure, and thus the tail risks of catastrophic global warming. Finally, using a sensitivity analysis, we consider which other aspects of nuclear energy deployment, apart from climate change, have the potential to overturn the ultimate ethical verdict on investments in nuclear energy. Out of several potential considerations, we suggest that its potential interplay — whether beneficial or adverse — with the proliferation of nuclear weapons is the most plausible candidate. (shrink)

This article focuses on the U.S. diplomat and nuclear arms control negotiator Gerald (Gerry) Coat Smith in order to cast new light on the importance of diplomats in the context of the set of international activities currently labelled as “science diplomacy.” Smith, a lawyer by training, was a key negotiator in many international agreements on post‐WW2 atomic energy projects, from those on uranium prospecting and mining, to reactors technologies to later ones on non‐proliferation and disarmament. His career in (...) science (nuclear) diplomacy also epitomized the shortcomings of efforts to align other countries’ posture on nuclear affairs to U.S. wishes. In particular, the unswerving diplomat increasingly understood that strong‐arm tactics to dissuade other countries from acquiring nuclear weapons would not limit proliferation. Not only did this inform later U.S. diplomacy approaches, but it lent itself to the ascendancy of the new notion of “soft power” as critical to the re‐definition of international affairs. (shrink)

Vietnam is a vibrant and emerging South East Asian economy. However, the country faces a challenging task in meeting rising energy demand and the need to securitize energy while addressing the negative environmental impact of fossil fuel utilization. Growing concerns about sustainable development have led Vietnam to develop civilian nuclear energy for electricity generation. Nuclear power is widely recognized as a clean, mature and reliable energy source. Its inclusion in Vietnam’s energy mix by 2030 is expected to supplement (...) other energy sources from fossil fuel, hydropower plants, renewable resources and energy imports. Despite strong reservations in the aftermath of the Fukushima disaster, Vietnam has pursued its national nuclearization program. Civilian nuclear energy development has been widely regarded as a controversial issue, although it is intended for peaceful purposes and as a solution for long-term energy security. Anxiety over nuclear safety measures, inadequate nuclear regulatory mechanisms, lack of institutionalized radioactive waste management, the threat of nuclear accident, theft and terrorism, and nuclear proliferation have marred public perception. The apprehension towards nuclear energy development has raised serious questions on the ethics and risks of the technology. Using a qualitative approach of reviewing published scholarly research, we investigated the ethical and risk issues that manifest in civilian nuclear energy development in Vietnam. Our findings reveal that the conundrum of civilian nuclear energy revolves around balancing energy security, environment preservation and societal well-being with ethical and risk predicaments of nuclear energy. (shrink)

The unmistakable onset of climate change has led many to advocate a major expansion of nuclear power. At best, however, nuclear power would only provide a small contribution to cutting greenhouse gas emissions, and it carries risks that other measures to the same end do not pose — especially that of nuclear weapons proliferation. It is argued that simple prudence favors a go-slow approach until the international community can establish robust proliferation constraints, and it is (...) evident that other carbon-free technologies do not suffice to meet the climate challenge. (shrink)

This paper approaches the choice between the open and closed nuclear fuel cycles as a matter of intergenerational justice, by revealing the value conflicts in the production of nuclear energy. The closed fuel cycle improve sustainability in terms of the supply certainty of uranium and involves less long-term radiological risks and proliferation concerns. However, it compromises short-term public health and safety and security, due to the separation of plutonium. The trade-offs in nuclear energy are reducible to (...) a chief trade-off between the present and the future. To what extent should we take care of our produced nuclear waste and to what extent should we accept additional risks to the present generation, in order to diminish the exposure of future generation to those risks? The advocates of the open fuel cycle should explain why they are willing to transfer all the risks for a very long period of time (200,000 years) to future generations. In addition, supporters of the closed fuel cycle should underpin their acceptance of additional risks to the present generation and make the actual reduction of risk to the future plausible. (shrink)

John Canaday, The Nuclear Muse: Literature, Physics, and the First Atomic Bombs. Madison: University of Wisconsin Press, 2000. Pp. xviii+310. ISBN 0-299-16854-9. £19.50.Septimus H. Paul, Nuclear Rivals: Anglo-American Atomic Relations 1941–1952. Columbus: Ohio State University Press, 2000. Pp. ix+266. ISBN 0-8142-0852-5. £31.95.Peter Bacon Hales, Atomic Spaces: Living on the Manhattan Project. Urbana and Chicago: University of Illinois Press, 1997. Pp. 448. ISBN 0-252-02296-3. £22.00.A decade after the end of the Cold War, the culture and technology of nuclear (...) weapons had lost much of the overt sense of dread they once inspired. The decline in international tension following the end of the communist regimes of the Soviet bloc produced a massive shift in the ideology of the nuclear in the 1990s. The de-targeting and dismantling of large numbers of nuclear weapons and the demise of the threat of nuclear annihilation created new conditions both for international security and for the writing of nuclear history. With the declassification and release of large quantities of official documentation from the former adversaries, as well as the fiftieth anniversary of the bombings of Hiroshima and Nagasaki in 1995, a burst of histories of various aspects of the nuclear age have appeared over the last ten years, exploring not just the technopolitics, strategy and operational logistics of the Cold War and the arms race, but the cultural history of the nuclear age, its imagery, its architecture, its oppositional politics and its effects on the landscape, national and regional economies and cultures and indeed everyday life. At a time of global economic and political uncertainty and the emergent threat of capricious international terrorism and new nuclear proliferation, the apparent certainties of the Cold War now even evoke a certain nostalgia, and its artefacts and structures are being recast as ‘heritage’. (shrink)

The 2016 United Nations’ Resolution 2325 “Non-proliferation of Weapons of Mass Destruction” manifests one of the greatest challenges for humankind in relation to preventing a global catastrophe, where it reaffirms that the proliferation of nuclear, chemical and biological weapons, as well as their means of delivery, constitutes a threat to international peace and security. However, regarding the continuous technological developments of terrestrial-based WMD aimed at orbiting space objects in near-Earth orbit, it is crucial to analyze whether, and (...) if so, how 2325 prevents their proliferation and utilization. Another relevant argument addresses the terminological factuality that, while treaty and customary law do provide some guidance on the legality of weaponization, the concept of a “space weapon” is still not clearly defined. Moreover, even though the Outer Space Treaty prohibits the placement of nuclear weapons and WMD in near-Earth orbit, installing them on the Moon or any other celestial body, or to otherwise station them in outer space, it simultaneously excludes terrestrial-based anti-satellite weapons, thus creating a legal loophole. National representatives of superpowers, particularly of space-faring nations, are aware of the existing issue and often express their concerns toward comprehensive ASAT development and utilization. Nevertheless, the potential weaponization of outer space will not be actively recognized and accepted as an official occurrence within the international community until our current space systems are eventually utilized in order to destroy or damage another State’s space object. (shrink)

Cell lines and cell samples from patients provide opportunities for studying the mechanisms of leukemic cellular differentiation and proliferation. Phorbol esters and 1,25 dihydroxy vitamin D3 can induce differentiation of myeloid leukemic cells to macrophages. Differentiation to granulocytes can be induced by several different compounds. Myeloid differentiation is associated closely with the alteration in expression of several oncogenes. These regulatory events may be associated with the extent of methylation, unfolding or association of chromatin to the nuclear matrix. Oncogene (...) amplification, mutation, or deletion can occur with malignant transformation. Future studies point to the development of specific pharmacological agents which can modify the neoplastic transformation. (shrink)

This book examines the moral philosophy of Paul Ramsey--one of the 20th century's most influential ethicists--from a theological perspective illustrating that religion can still play a substantial role in our ongoing moral inquiries. Ramsey wrote prodigiously on ethical issues including politics, medical research, the Vietnam war, and nuclear proliferation. His ethical theory, which concentrates on divine love, or `agape, ' as well as justice and order, provides a middle ground between fundamentalism and secularism. Therefore, Ramsey's ethics will appeal (...) to the 21st-century social conscience. McKenzie grounds his theological exploration in a comprehensive history of the theological and philosophical influences on Ramsey's thought, including Jonathan Edwards' theory of natural morality. He also explores a multidisciplinary selection of Ramsey's writings. In conclusion, McKenzie argues that Ramsey's natural law theory will continue to have significant and increasing relevance for morality in the postmodern world. This is the most thorough study of Paul Ramsey's work as well as a significant contribution to philosophy and theology. (shrink)

Veteran scholar and peace activist David Cortright offers a definitive history of the human striving for peace and an analysis of its religious and intellectual roots. This authoritative, balanced, and highly readable volume traces the rise of peace advocacy and internationalism from their origins in earlier centuries through the mass movements of recent decades: the pacifist campaigns of the 1930s, the Vietnam antiwar movement, and the waves of disarmament activism that peaked in the 1980s. Also explored are the underlying principles (...) of peace - nonviolence, democracy, social justice, and human rights - all placed within a framework of 'realistic pacifism'. Peace brings the story up-to-date by examining opposition to the Iraq War and responses to the so-called 'war on terror'. This is history with a modern twist, set in the context of current debates about 'the responsibility to protect', nuclear proliferation, Darfur, and conflict transformation. (shrink)

Our present moral traits are unable to provide the level of large-scale co-operation necessary to deal with risks such as nuclear proliferation, drastic climate change and pandemics. In order to survive in an environment with powerful and easily available technologies, some authors claim that we need to improve our moral traits with moral enhancement. But this is prone to produce paradoxical effects, be self-reinforcing and harm personal identity. The risks of moral enhancement require the use of a safety (...) framework; such a framework should guarantee practical robustness to moral uncertainty, empirical adequacy, correct balance between dispositions, preservation of identity, and be sensitive to practical considerations such as emergent social effects. A virtue theory can meet all these desiderata. Possible frameworks incorporate them to variable degrees. The social value orientations framework is one of the most promising candidates. (shrink)

To a world assaulted by private interests, this book argues that peace must be a public thing. Distinguished philosophers of peace have always worked publicly for public results. Opposing nuclear proliferation, organizing communities of the disinherited, challenging violence within status quo establishments, such are the legacies of truly engaged philosophers of peace. This volume remembers those legacies, reviews the promise of critical thinking for crises today, and expands the free range of thinking needed to create more mindful and (...) peaceful relations. With essays by committed peace philosophers, this volume shows how public engagement has been a significant feature of peace philosophers such as Camus, Sartre, Dewey, and Dorothy Day. Today we also confront historical opportunities to transform practices for immigration, police interrogation, and mental health, as we seek to sustain democracies of increasing multicultural diversity. In such cases our authors consider points of view developed by renowned thinkers such as Weil, Mouffe, Conway, and Martín-Baró. This volume also presents critical analysis of concepts for thinking about violence, reconsiders Plato’s philosophy of justice, and examines the role of ethical theory for liberation struggles such as Occupy! (shrink)

Anders was a preeminent critic of technology and critic of the atomic bomb as he saw this hermeneutico-phenomenologically in the visceral sense of beingand time: the sheer that of its having been used as well as the bland politics of nuclear proliferation functions as programmatic aggression advanced in the name of defense and deterrence. The tactic ofsheerly technological, automatic, mechanical, aggression is carried out in good conscience. The preemptive strike is, as Baudrillard observed, the opponent’s fault: such are (...) the wages of evil. Violence in good conscience characterizes the postwar, cold war era and the present day with its mushrooming effects ofneo-fascism under the titles of national security and anti-terrorism. Karl Krauss’ 1913 bon mot regarding psychoanalysis as the very insanity it claims to cure [Psychoanalyse ist jene Geisteskrankheit, für deren Therapie sie sich halt] has never been more apt for political translation—straight into the heart of what Lacan called the Real which has ‘always been’ the political register. Where Habermas and heirs have tended to disregard Anders , just as most philosophers of technology have ignored the political as well as theethical in their eagerness to avoid suspicion of technophobia, we continue to require both critical theory and a critical philosophy of technology, a conjunction incorporating Ander’s complicated dialectic less of art in Benjamin’s prescient but still innocent age of technological reproduction but and much rather “on the devastation of life in the age of the third industrial revolution.” Thus rather thanreading Anders’ critique of the bomb as limited to a time we call the Atomic Age—as Anders himself varied Samuel Beckett’s 1957 Endgame asEndzeit that is “Endtime,” here invoking the eschatological language of Jacob Taubes as Anders does—this essay connects his reflections on the bomb with his critique of technology and the obsolescence of humanity as of a piece with our dedication to hurling ourselves against our own mortality. This concern with the violence of technology, this hatred of the vulnerability of having been born and having been set on a path unto death inspires Anders’ engagement with the sons of Eichmann—the heirs of those who designed and executed the Nazi death camps and extermination chambers of the Holocaust—and the sons of Claude Eatherly—the heirs ofboth those who designed and those who as pilots deployed the bombings that exploded nothing the stuff of the sun itself against the Empire of the Sun in the attacks on Hiroshima and Nagasaki. We, embroiled as we are in wartime after wartime, suppressing public protest on a scale like never before, in country after country across the globe, cannot dispense with Anders today. (shrink)

A new argument has been made against moral enhancement by authors who are otherwise in favour of human enhancement. Additionally, they share the same evolutionary toolkit for analysing human traits as well as the belief that our current morality is unfit to deal with modern problems, such as climate change and nuclear proliferation. The argument is put forward by Buchanan and Powell and states that other paths to moral progress are enough to deal with these problems. Given the (...) likely costs and risks involved with developing moral enhancement, this argument implies moral enhancement is an unpromising enterprise. After mentioning proposed solutions to such modern problems, I will argue that moral enhancement would help implement any of them. I will then detail Buchanan and Powell’s new argument disfavouring moral enhancement and argue that it makes too bold assumptions about the efficacy of traditional moral progress. For instance, it overlooks how that progress was to achieve even in relatively successful cases such as the abolition of slavery. Traditional moral progress is likely to require assistance from non-traditional means in order to face new challenges. (shrink)

In a world fraught with violence in its macabre form, it is essential to have a broad and clear understanding of the principle of non-violence (ahimsa), its various nuances, its potential and limitations. Covering a span of wisdom literature on the Indian ethos from the times of the Upanishads to the works of modern seers like Gandhi, Tagore and Aurobindo, the author presents the notions of non-violence and violence along a finely graduated scale instead of going into sharp polarities. While (...) making a clear distinction between gross physical violence and the subtle play of violence in words, thoughts and ideas, the paper goes on to offer a critique of modern technology and nuclear proliferation for perpetrating violence on nature and fellow human beings in the name of progress and development. While expressing his admiration for the Gandhian principle of non-violence, the author advocates practical idealism that admits violence with caution but without hatred for the purpose of general welfare (lokasamgraha), along the lines of the messages of Krishna in the Gita. This is of practical necessity till such time as the world has been awakened to a heightened level of spiritual consciousness. (shrink)

What accounts for the apocalyptic angst that is now so clearly present among Americans who do not subscribe to any religious orthodoxy? Why do so many popular television shows, films, and music nourish themselves on this very angst? And why do so many artists—from Coldplay to Tori Amos to Tom Wolfe—feel compelled to give it expression? It is tempting to say that America’s fears and anxieties are understandable in the light of 9/11, the ongoing War on Terror, nuclear (...) class='Hi'>proliferation, and the seemingly limitless capacity of science to continually challenge our conceptions of the universe and ourselves. Perhaps, too, American culture remains so permeated by Protestant Christianity that even avowed skeptics cannot pry themselves from its grip. In _A Consumer’s Guide to the Apocalypse,_ Eduardo Velásquez argues that these answers are too pat. Velásquez’s astonishing thesis is that when we peer into contemporary artists’ creative depiction of our sensibilities we discover that the antagonisms that fuel the current cultural wars stem from the same source. Enthusiastic religions and dogmatic science, the flourishing of scientific reason and the fascination with mystical darkness, cultural triumphalists and multicultural ideologues are all sustained by the same thing: a willful commitment to the basic tenets of the Enlightenment. Velásquez makes his point with insightful readings of the music of Coldplay, Tori Amos, and Dave Matthews and the fiction of Michael Frayn’s _Copenhagen,_ Chuck Palahniuk’s _Fight Club,_ and Tom Wolfe’s _I Am Charlotte Simmons._ Written with grace and humor, and directed toward the lay reader, _A Consumer’s Guide to the Apocalypse_ is a tour de force of cultural analysis. (shrink)

As world leaders strengthen their nuclear arsenals, and fears of global nuclear proliferation increase, social studies teachers must be prepared to help learners investigate the devastating consequences on human life and property associated with their use. This manuscript presents an ethnological study of six atomic bomb survivors from Hiroshima and Nagasaki during World War II. Participants completed a qualitative questionnaire describing their experiences during World War II, and making recommendations to U.S. social studies teachers when teaching about (...) the dropping of the atomic bombs in Hiroshima and Nagasaki in Japan. Data was analyzed to identify patterns and themes, and two categories emerged related to our research question. Findings suggest participants support U.S. teachers imparting global perspectives that speak directly to the destructive power of the atomic bomb and its impact on humans and the environment for years to come. This includes a movement away from using the social studies curriculum to point fingers of historic blame in the use of atomic weapons, and towards empowering learners to become agents of change in actualizing a nuclear free and peaceful world. We discuss the implications of this study's findings in social studies and global education. (shrink)

Il y a trois défis pour la sécurité de l’Ouest. Le premier est que l’Ouest, comparé à l’Asie de l’Est, est en déclin. Dans vingt-cinq ans, la taille économique de la Chine continentale pourrait être supérieure à la taille du marché américain ; celle de l’Inde et de l’Indonesie être supérieure à la taille économique de l’Allemagne ; celle de la Corée du Sud excéder l’Angleterre ou la France ou l’Italie. Le second est la prolifération d’un savoir à doubleemploi et (...) le désastre économique de l’ex-Union Soviétique qui auront pour conséquence vraisemblable une prolifération du nucléaire. Le troisième concerne les changements de valeurs qui s’opèrent à l’Ouest et qui favorisent la formation de sociétés occidentales de moins en moins aptes à attaquer ou à se défendre. Mais la réduction du poids de l’Occident dans l’économie globale ne garantit plus que les efforts faciles l’emportent face aux défis du futur, qu’ils viennent des pouvoirs renforcés de l’Est asiatique ou des “desperados” islamiques. Ces défis ne seront vraisemblablement pas relevés au moyen de deux fausses prescriptions qui trouvent quelques faveurs en Europe Continentale. Premièrement, une grande partie de l’Europe de l’Ouest est lasse d’être confrontée à la “destruction créatrice” de ses emplois du fait de la concurrence de l’Asie de l’Est et désire ardemment le protectionnisme. Le remède protectionniste se bâtit sur un diagnostic grandement correct des problèmes occidentaux, mais il est tout de même dangereux si l’on met en perspective la morale, l’économie et la politique du pouvoir. Deuxièmement, certains Européens reconnaissent à juste titre que les grandes puissances historiques, comme la Grande- Bretagne ou la France ou l’Allemagne, n’ont plus une envergure suffisante pour être qualifiées de grandes puissances. Cependant, elles sousestiment la gravité et la vitesse du déclin de l’Occident. Une Europe définie par le noyau dur francoallemand deviendra trop étroite, avant même qu’elle ne soit établie dans cette structure. Vraisemblablement, même l’Union Européenne dans sa totalité sera trop petite avant qu’elle ne devienne une véritable communauté sur le plan sécuritaire. Au lieu de ces fausses prescriptions, cet article propose trois réponses aux dilemmes de l’Occident, ou encore trois façons de gérer le déclin de l’Occident. Premièrement, seule la coopération atlantique promet d’être une réponse efficace au dynamisme de l’Asie de l’Est et au déclin de l’Ouest. De plus, la coopération entre l’Amérique du Nord et l’Europe de l’Ouest a besoin d’être complétée par un nouvel engagement à l’égard d’une économie globale ouverte et d’une disposition à s’ajuster aux défis de celle-ci, afin de coopter l’Est asiatique dans une sphère globale de coprospérité. Cela doit vraisemblablement engendrer quelques coupes radicales dans l’Etat-providence. Deuxièmement, la prolifération nucléaire exige aussi une réponse. Il est concevable que la stratégie de défense contre la Chine soit encore plus difficile dans une vingtaine d’années qu’elle le fut contre l’Union Soviétique dans les années 1980. Mais cela ne devrait pas être une excuse pour ne pas construire des missiles de défense en réponse à ceux de l’Iran, de l’Irak, de la Lybie ou de l’Algerie. Troisièmement, les changements des valeurs en Occident semblent plus difficiles à traiter, mais ils renforcent la nécessité d’investir dans la coopération occidentale plutôt qu’uniquement européenne, la nécessité de coopter l’Asie de l’Est plutôt que de plonger dans une autre guerre froide, et la nécessité de contenir l’Etat-providence plutôt que de le développer. There are three challenges to Western security. First, compared to East Asia the West is in decline. In another twenty-five years, the economic size of Mainland China may exceed the size of the American market, India and Indonesia may exceed Germany, South Korea may exceed Britain or France or Italy. Second, the proliferation of dual use knowledge and the economic disaster in the former Soviet Union are likely to result in some nuclear proliferation. Third, value changes within the West will make Western societies ever less capable of deterrence and defense. But the reduced weight of the West in the global economy no longer guarantees that leisurely efforts succeed in meeting future challengers, whether from East Asian great powers or Islamic desperados. These challenges are unlikely to be met by two false prescriptions which enjoy some appeal in Continental Europe. First, much of Western Europe gets tired of observing the “creative destruction” of its jobs by East Asian competitors and longs for protectionism. The protectionist cure is built on a largely correct diagnosis of some Western problems, but nevertheless dangerous from an economic, moral, and power politics perspective. Second, some Europeans rightly recognize that historical great powers, like Britain or France or Germany, are no longer large enough to be great powers. But they underestimate the severity and speed of the decline of the West. A Franco- German core Europe will become too small, even before it is established. Conceivably, even the entire European Union will be too small before it becomes an effective security community. Instead of these false prescriptions this paper advocates three responses to Western dilemmas, or three modes of managing Western decline. First, only Atlantic cooperation promises to be an effective response to East Asian dynamism and Western decline. Moreover, cooperation between North America and Western Europe needs to be complemented with a renewed commitment to an open global economy and a readiness to adjust to its challenges, in order to coopt East Asia into a global co-prosperity sphere. This is likely to necessitate some radical cuts in the welfare state. Second, nuclear proliferation also needs some response. Conceivably, strategic defense is as difficult against China twenty years from now, as it was against the Soviet Union in the 1980s. But this should be no excuse for not building a missile and air defense against the likes of Iran, Iraq, Lybia, or Algeria. Third, the value changes within the West seem least tractable, but they reinforce the necessity of investing in Western rather than merely European cooperation, the necessity of coopting East Asia rather than stumbling into another Cold War, and the necessity for containing the welfare state rather than expanding it. (shrink)

The increasing proliferation of the automobile is one of the hardest practical and ethical problems contemporary societies face, in terms of technology production and use. Nuclear weaponry may be our number one threat, but it is in the hands of a very few, almost inaccessible people. Nanotechology may tum the planet into a "gray goo," in Bill Joy's famous terms; and "superintelligent" machines and "uploaded minds" may engender megalomaniacal power-seekers; but such technologies remain highly speculative. Yet, the automobile (...) is both very real and at hand, as well as in the hands—and daily options—of cotnmon persons who can choose not to use it each time they step into the driver's seat. These daily choices are precisely what Calkins's "automobile proponents' strategies," as if one monohthic force, aim on controlling. He marshals impressive and sobering statistics and evidence to show that not only are the numbers of automobiles in China and India rising astronomically, but a few key persons and agencies are pushing this increase and thus—in full awareness—altering these countries' habitability. It is this full awareness that forms the basis of the book's ethical criticism. (shrink)

From Knowledge to Wisdom argues that there is an urgent need, for both intellectual and humanitarian reasons, to bring about a revolution in science and the humanities. The outcome would be a kind of academic inquiry rationally devoted to helping humanity learn how to create a better world. Instead of giving priority to solving problems of knowledge, as at present, academia would devote itself to helping us solve our immense, current global problems – climate change, war, poverty, population growth, pollution... (...) of sea, earth and air, destruction of natural habitats and rapid extinction of species, injustice, tyranny, proliferation of armaments, conventional, chemical, biological and nuclear, depletion of natural resources. The basic intellectual aim of inquiry would be to seek and promote wisdom – wisdom being the capacity to realize what is of value in life for oneself and others, thus including knowledge and technological know-how, but much else besides. This second edition has been revised throughout, has additional material, a new introduction and three new chapters. (shrink)

There have always been some uninhabitable places, but in the last century human beings have produced many more of them. These anti-landscapes have proliferated to include the sandy wastes of what was once the Aral Sea, severely polluted irrigated lands, open pit mines, blighted nuclear zones, coastal areas inundated by rising seas, and many others. _The Anti-Landscape_ examines the emergence of such sites, how they have been understood, and how some of them have been recovered for habitation. The anti-landscape (...) refers both to artistic and literary representations and to specific places that no longer sustain life. This history includes T. S. Eliot’s _Wasteland_ and Cormac McCarthy’s _The Road_ as well as air pollution, recycled railway lines, photography and landfills. It links theories of aesthetics, politics, tourism, history, geography, and literature into the new synthesis of the environmental humanities. _The Anti-Landscape_ provides an interdisciplinary approach that moves beyond the false duality of nature vs. culture, and beyond diagnosis and complaint to the recuperation of damaged sites into our complex heritage. _This is the first volume in the new series _Studies in Environmental Humanities_._. (shrink)

On September 27, 2016 people across the world looked down at their buzzing phones to see the AP Alert: “Baby born with DNA from 3 people, first from new technique.” It was an announcement met with confusion by many, but one that polarized the scientific community almost instantly. Some celebrated the birth as an advancement that could help women with a family history of mitochondrial diseases prevent the transmission of the disease to future generations; others held it unethical, citing medical (...) tourism and consequences for the future of the therapy. The child in question was actually born a few months earlier on April 6, 2016, but the research was published a few months later in the October edition of Fertility and Sterility. The mother carries DNA that could have given the baby Leigh Syndrome, a severe neurological disorder characterized by psychomotor regression that typically results in death between ages two and three.[1] Also known as subacute necrotizing encephalomyelopathy, Leigh Syndrome is caused by genetic mutations in mitochondrial DNA, which causes defective oxidative phosphorylation. Because people with this condition cannot re-form ATP, “demyleniation, gliosis, necrosis, spongiosis, or capillary proliferation”[2] can occur, thereby producing bilateral lesions across the central nervous system. The 36-year-old mother previously had four miscarriages and successfully birthed two children, both of whom survived less than six years due to the syndrome. For religious reasons, the mother opted for Spindle Nuclear Transfer instead of Pronuclear Transfer,[3] which many religious organizations oppose because it entails the destruction of fertilized eggs.[4] In Pronuclear Transfer, both the parent and donor egg are fertilized. The parent’s nuclear material is then removed from the egg containing mutated mitochondria and inserted into the fertilized donor egg—from which the original nuclear material has been removed and destroyed. Spindle Nuclear Transfer, on the other hand, removes the mother’s nuclear material from the egg with unhealthy mitochondria, then implants it into a donor’s egg. The newly created egg is then fertilized with the father’s sperm. This Spindle Nuclear Transfer was performed in Mexico by a team of doctors led by Dr. John Zhang, the founder of the New Hope Fertility Center in New York City. In their report, the doctors outline that five oocytes were successfully reconstituted, four of which developed into blastocysts. Only one was euploid: containing 46 XY chromosomes. Researchers then biopsied that blastocyst and found that the transmission rate of maternal mtDNA was, “5.10 ± 1.11% and the heteroplasmy level for 8993T>G was 5.73%.”[5] This indicates that at the blastocyst stage, around five percent of the mitochondria are from the original maternal egg with the mutation for Leigh Syndrome. After birth, they biopsied different tissues and found that they had an average of less than 1.60 ± 0.92% of transmitted mtDNA from the original maternal egg. The baby is reportedly doing well and the team of doctors concluded that “[h]uman oocytes reconstituted by SNT are capable of producing a healthy live birth. SNT may provide a novel treatment option in minimizing pathogenic mtDNA transmission from mothers to their babies."[6] Even when considered theoretically, Spindle Nuclear Transfer is controversial. Many doctors believe that the risks at this stage of research are too great. Dr. Trevor Stammers, a bioethicist at St. Mary’s University in London, points out: “We do not yet have a clear picture of the interaction between nuclear DNA and mitochondria.”[7] Others hold that faulty mitochondrial DNA can still be transferred during the procedure. Still more argue this technology could create problems because of germline modification.[8] Dr. Paul Knoepfler, a cell biologist at the UC Davis School of Medicine, explains: “Since this is uncharted territory and the children born from this technology would have heritable genetic changes, there are also significant unknown risks to future generations.”[9] However, proponents counter these arguments. They say the benefits outweigh the risks, as “mitochondrial replacement techniques [like Spindle Nuclear Transfer] would eliminate maternal transmission of mitochondrial disease… allowing a woman with a family history of mitochondrial diseases to ensure her children would not be affected.”[10] Additionally, experts say that no symptoms will occur if less than 20% of the transferred mitochondrial DNA is faulty.[11] And while opponents see potential germline modification as a problem, advocates answer that this could stop a family history of mitochondrial disease, which they deem a more serious concern. In this case specifically, however, there are more issues at hand. While the team of doctors did eliminate the possibility of germline modification by selecting a male embryo, there are other ethical concerns. Some argue that this case could be described as “medical tourism.” While New Hope Medical Clinic does maintain a branch in Mexico, Dr. Zhang stated that Mexico has “no rules.”[12] It is a country with underdeveloped regulations, making it difficult to confirm that doctors adhere to widely-held medical and ethical standards. Furthermore, while it is highly unlikely that the child will develop Leigh’s Syndrome, Dr. Dietrich Egli of the New York Stem Cell Foundation says the 5% mitochondrial transfer rate indicates that the technique “was not carried out well.”[13] He points to studies of embryos where the rate of mtDNA transfer was almost ten times lower. Spindle Nuclear Transfer is currently legal in the UK,[14] and many are hoping to see it legalized in the US, although Congress currently prohibits the FDA from considering applications that would entail trials in people.[15] While Dr. Zhang’s work is arguably revolutionary, many wonder if the manner in which this study was performed—in Mexico and with a high mitochondrial transfer rate—will impact the technology’s future in the US. Last week, Dr. Zhang presented the report to scientists gathered in Salt Lake City, saying that while science isn’t a race, it is “in a sense, a race for the family to find a cure, to find hope.”[16] Only time will tell if this study set back other families racing and hoping for a cure. References 1. "Leigh Syndrome." Genetics Home Reference, US National Library of Medicine, 25 Oct. 2016. Accessed 26 Oct. 2016. 2. McKusick, Victor A., and Ada Hamosh. "LEIGH SYNDROME; LS." Online Mendelian Inheritance in Man, Johns Hopkins University, 20 Jan. 2016. Accessed 30 Oct. 2016. 3. Zhang, J, H Liu, S Luo, A Chavez-Badiola, and Z Liu. "First live birth using human oocytes reconstituted by spindle nuclear transfer for mitochondrial DNA mutation causing Leigh syndrome." Fertility and Sterility, vol. 106, no. 3, 2016, pp. e375-76. Accessed 30 Oct. 2016. 4. Sample, Ian. "‘Three-parent’ babies explained: what are the concerns and are they justified?" The Guardian, 2 Feb. 2015. Accessed 30 Oct. 2016. 5. Zhang, et al. 6. Ibid. 7. Knapton, Sarah. "Three-parent babies: the arguments for and against." The Telegraph, 3 Feb. 2015. 8. Ibid. 9. Ibid. 10. "Mitochondrial Replacement Therapy FAQs." New York Stem Cell Foundation Research Institute, New York Stem Cell Foundation. Accessed 30 Oct. 2016. 11. Reardon, Sara. "‘Three-parent baby’ claim raises hopes — and ethical concerns." Nature, 28 Sept. 2016. Accessed 30 Oct. 2016. 12. Hamzelou, Jessica. "Exclusive: World’s first baby born with new “3 parent” technique." New Scientist, 27 Sept. 2016. Accessed 30 Oct. 2016. 13. Reardon, Sara. "‘Three-parent baby’ claim raises hopes — and ethical concerns." Nature, 28 Sept. 2016. Accessed 30 Oct. 2016. 14. "3-Person IVF: A Resource Page." Center for Genetics and Society, 24 Oct. 2016. Accessed 30 Oct. 2016. 15. Ritter, Malcolm. "Baby born with DNA from 3 people, first from new technique." Associated Press, 27 Sept. 2016. Accessed 30 Oct. 2016. 16. Chen, Daphne. "Controversy swirls around first three-parent baby." Deseret News, 19 Oct. 2016. Accessed 30 Oct. 2016. Works consulted Swetlitz, Ike. "FDA urged to approve ‘three-parent embryos,’ a new frontier in reproduction." STAT, 3 Feb. 2016. Accessed 30 Oct. 2016. (shrink)

MicroRNAs are non-coding parts of nuclear and mitochondrial genomes, preventing the weakest part of the genetic regulatory networks from being expressed and preventing the appearance of a too many attractors in these networks. They have also a great influence on the chromatin clock, which ensures the updating of the genetic regulatory networks. The post-transcriptional inhibitory activity by the microRNAs, which is partly unspecific, is due firstly to their possibly direct negative action during translation by hybridizing tRNAs, especially those inside (...) the mitochondrion, hence slowing mitochondrial respiration, and secondly to their action on a large number of putative m-RNA targets like those involved in immunetworks; We show that the circuits in the core of the interaction graphs are responsible for the small number of dedicated attractors that correspond to genetically controlled functions, partly due to a general filtering by the microRNAs. We analyze this influence as well as their impact on important functions like the control by the p53 network over the apoptosis/proliferation system and the homeostasis of the energy metabolism. In this last case, we show the role of two kinds of microRNAs, both involved in the control of the mitochondrial genome: (1) nuclear microRNAs, called mitoMirs, inhibiting mitochondrial genes and (2) putative mitochondrial microRNAs inhibiting the tRNAs functioning. (shrink)

Pax genes are a family of development control genes that encode nuclear transcription factors. They are characterized by the presence of the paired domain, a conserved amino acid motif with DNA‐binding activity. Originally, paired‐box‐containing genes were detected in Drosophila malenogaster, where they exert multiple functions during embryogenesis. In vertebrates, Pax genes are also involved in embryogenesis. Mutations in four out of nine characterized Pax genes have been associated with either congenital human diseases such as Waardenburg syndrome (PAX3), Aniridia (PAX6), (...) Peter's anomaly (PAX6), renal coloboma syndrome (PAX2), Small eye (Pax6), (Pax21Neu), which all show defects in development. Recently, analysis of spontaneous and transgenic mouse mutants has revealed that vertebrate Pax genes are key regulators during organogenesis of kidney, eye, ear, nose, limb muscles, vertebral column and brain. Like their Drosophila counterparts, vertebrate Pax genes are involved in pattern formation during embryogenesis, possibly by determiing the time and place of organ initiation of morphogenesis. For most tissues, however, the nature of the primary development action of Pax transcription factors remains to be elucidated. One predominant theme is signal transduction during tissue interactions, which may lead to a position‐specific regulation of cell proliferation. (shrink)

Poly(ADP‐ribosyl)ation is an immediate DNA‐damage‐dependent post‐translational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. Poly(ADP‐ribose) polymerases (PARPs) now constitute a large family of 18 proteins, encoded by different genes and displaying a conserved catalytic domain in which PARP‐1 (113 kDa), the founding member, and PARP‐2 (62 kDa) are so far the sole enzymes whose catalytic activity has been shown to be immediately stimulated by DNA strand breaks. A large repertoire of sequences (...) encoding novel PARPs now extends considerably the field of poly(ADP‐ribosyl)ation reactions to various aspects of the cell biology including cell proliferation and cell death. Some of these new members interact with each other, share common partners and common subcellular localizations suggesting possible fine tuning in the regulation of this post‐translational modification of proteins. This review summarizes our present knowledge of this emerging superfamily, which might ultimately improve pharmacological strategies to enhance both antitumor efficacy and the treatment of a number of inflammatory and neurodegenerative disorders. A provisional nomenclature is proposed. BioEssays 26:882–893, 2004. © 2004 Wiley Periodicals, Inc. (shrink)