Osteoclasts, the multinucleated cells primarily responsible for dissolution of bone tissue, form by fusion of precursors that circulate in the bloodstream. A variety of factors have been shown to affect the mature osteoclast and its progenitor cell, such as calcium‐regulating hormones, products of the immune system, and constituents of the arachidonic acid cascade. To date, however, the osteoclast precursor has not been identified. Furthermore, there is limited information on the factors that influence osteoclast development and regulation, reflecting in part the (...) paucity of data on the osteoclast cell surface. Recent progress in understanding osteoclasts formation and function is discussed. (shrink)

Several technological developments, such as self-service technologies and artificial intelligence, are disrupting the retailing industry by changing consumption and purchase habits and the overall retail experience. Although AI represents extraordinary opportunities for businesses, companies must avoid the dangers and risks associated with the adoption of such systems. Integrating perspectives from emerging research on AI, morality of machines, and norm activation, we examine how individuals morally behave toward AI agents and self-service machines. Across three studies, we demonstrate that consumers’ moral concerns (...) and behaviors differ when interacting with technologies versus humans. We show that moral intention is less likely to emerge for AI checkout and self-checkout machines compared with human checkout. In addition, moral intention decreases as people consider the machine less humanlike. We further document that the decline in morality is caused by less guilt displayed toward new technologies. The non-human nature of the interaction evokes a decreased feeling of guilt and ultimately reduces moral behavior. These findings offer insights into how technological developments influence consumer behaviors and provide guidance for businesses and retailers in understanding moral intentions related to the different types of interactions in a shopping environment. (shrink)

Author note: Penny A. Weiss, Associate Professor of Political Science at Purdue University, is the author of Gendered Community: Rousseau, Sex, and Politics. Marilyn Friedman, Associate Professor of Philosophy at Washington University, is the author of What Are Friends For? Feminist Perspectives on Personal Relationships and Moral Theory.

If cultures are always in the making, this book catches one kind of culture on the make. Academics will be familiar with audit in the form of research and teaching assessments - they may not be aware how pervasive practices of 'accountability' are or of the diversity of political regimes under which they flourish. Twelve social anthropologists from across Europe and the Commonwealth chart an influential and controversial cultural phenomenon.

A distinguished philosopher and a practicing minister, Marilyn McCord Adams has written a highly original work on a fundamental dilemma of Christian thought -- ...

When people engage in conversation, they tailor their utterances to their conversational partners, whether these partners are other humans or computational systems. This tailoring, or adaptation to the partner takes place in all facets of human language use, and is based on a mental model or a user model of the conversational partner. Such adaptation has been shown to improve listeners' comprehension, their satisfaction with an interactive system, the efficiency with which they execute conversational tasks, and the likelihood of achieving (...) higher level goals such as changing the listener's beliefs and attitudes. We focus on one aspect of adaptation, namely the tailoring of the content of dialogue system utterances for the higher level processes of persuasion, argumentation and advice‐giving. Our hypothesis is that algorithms that adapt content for these processes, according to a user model, will improve the usability, efficiency, and effectiveness of dialogue systems. We describe a multimodal dialogue system and algorithms for adaptive content selection based on multi‐attribute decision theory. We demonstrate experimentally the improved efficacy of system responses through the use of user models to both tailor the content of system utterances and to manipulate their conciseness. (shrink)

To understand the radical potential of Heidegger’s model of practice, we need to acknowledge the role that temporality plays within it. Commentaries on Heidegger’s account of practical engagement, however, often leave the connection between purposiveness and temporality unexplored, a tendency that persists in the contemporary discourse generated by the interaction between the phenomenological tradition and certain approaches within cognitive science. Taking up a temporality-oriented reading that redresses this can, I want to argue here, reveal new illuminating sites for the intersection (...) between phenomenology and the cognitive sciences, particularly between Heideggerian perspectives and what have become known as enactive approaches to the study of cognition. According to the latter, cognition is an inherently relational process through which the interaction of a living being and its environment generates meaning and, ultimately, a world of significance defined by the cogniser’s self-concern. I will suggest that this emphasis upon the inextricable intertwining of agent and world renders enactive models of cognition particularly congenial to a mutually enriching dialogue with Heidegger’s account of purposiveness, particularly if we read the latter in terms of the temporal framework that Being and Time offers us. (shrink)

Politics of Reality includes nine essays that examine sexism, the exploitation of women, the gay rights movement and other topics from a feminist perspective. -/- The essays "The Problem That Has No Name" and "A Note On Anger" have been translated into Spanish by Maria Lugones for circulation in la Asociacion Argentina de Mujeres en Filosofia.

Transforming our worldviews -- Transforming the fear of death -- Glimpses beyond death and the physical world -- Cosmologies of life, death, and beyond -- Science of the afterlife -- The practice of dying -- Grief as a doorway to transformation -- Dreaming and the transformation of death -- Transformative art -- Life, death, and the quantum soul -- Healing self and society.

(1997). Intentionality: An argument for transpersonal consciousness distant. World Futures: Vol. 48, The Concept of Collective Consiousness: Research Perspectives, pp. 115-126.

(2010). Approaches to behavior and classroom management: integrating discipline and care. Journal of Moral Education: Vol. 39, No. 4, pp. 524-526. doi: 10.1080/03057240.2010.521408.

The problem of evil is one of the most discussed topics in the philosophy of religion. For some time, however, there has been a need for a collection of readings that adequately represents recent and ongoing writing on the topic. This volume fills that need, offering the most up-to-date collection of recent scholarship on the problem of evil. The distinguished contributors include J.L. Mackie, Nelson Pike, Roderick M. Chisholm, Terence Penelhum, Alvin Plantinga, William L. Rowe, Stephen J. Wykstra, John Hick, (...) and Diogenes Allen. Including an introductory essay and a selected bibliography, this comprehensive and completely up-to-date collection is an invaluable guide to current scholarship in this highly debated area of the philosophy of religion. Oxford Readings in Philosophy aims to bring together important recent writings in major areas of philosophical inquiry, selected from a variety of sources, mostly periodicals, which may not be conveniently available. (shrink)

The purpose of this study was to look beyond the patient as the source of difficulty and to examine the context of care encounters for factors that contributed to the construction of difficulty in the nurse-patient encounter. The study explains the origins of difficulty in the nurse-patient encounter. This explanation broadens the thinking limits previously imposed by locating difficulty within the individual. Key elements of this explanation are: knowing the patient minimizes the likelihood of difficulty in the encounter; and families, (...) availability of supplies and equipment, who is working, and care space changes are contextual factors that contribute to the construction of difficulty in the nurse-patient encounter. Awareness of these findings has implications for the strategies nurses employ in difficult encounters. (shrink)

Kierkegaard is considered by many to be the father of existentialism because he is believed to have asserted that our interpretations of existence are the expression of absolutely free choices, or choices for which no rational criteria can be given. This paper argues that that view is false. It presents a sketch of Kierkegaard position on the nature of human rationality, and argues that according to Kierkegaard, there are rational criteria for choosing between competing interpretations of existence and that people (...) make such choices only with reference to these criteria. (shrink)

Africanisation refers to a renewed focus on Africa, a reclaiming of what has been taken from Africa, and forms part of a post-colonialist and an anti-racist discourse. Africanising the curriculum involves developing scholarship and research established in African intellectual traditions. The idea is that this education will produce people who are not alienated from their communities and are sensitive to the challenges facing Africa. However, the idea of Africanisation is highly contested and may evoke a false or at least a (...) superficial sense of 'belonging,' further marginalisation, or it may emphasise relevance. This article discusses the possibility of Africanisation and takes further the argument of Graham Duncan of how Africans can reclaim their voices in the space of theological education. It unpacks the idea of Africanisation within higher education in general, examining the rationale behind the calls for Africanisation, followed by a discussion on the implications of Africanisation for theological education. (shrink)

This essay investigates the constitution of the principal research question on women in ancient Greece, namely, the status of women in ancient Athens, and attempts to formulate a historiography for it under three headings. "Patriarchy and Misogyny" reviews the history of the question, from the time of its canonical formulation by A. W. Gomme in 1925, back to its initial constitution as a scholarly question by K. A. Böttiger in 1775, and up to its conceptualization in contemporary and feminist scholarship. (...) This section concludes with a statement on the historiographical inadequacy of this research question, and suggests that a historiographically appropriate formulation must be based on a reconsideration of the ideology which informed the initial constitution of the research issue."Women in Civil Society" investigates the ideological underpinnings of the late eighteenth- and nineteenth-century scholarly orthodoxy, concluding that it was founded on a historiographical tautology--with the example of women in ancient Athens providing the basis for eighteenth-century views on women's exclusion from civil society, and with the latter serving as the foundation for the investigation of women in ancient Greece. This section concludes with a discussion of some recent work in which the areas of investigation have been reformulated, but notes the overall exclusion from this work of issues having to do with race and sexuality."Race, Culture, and Sexuality" takes up the treatment of women in ancient Greece by Christoph Meiners who, in 1778, was one of the earliest to bring together considerations of cultural particularity with that of women's status. This section goes on to show how the eighteenth- and nineteenth-century reformulations of ancient medical theory generated the notions of race and sex as biological essences, and invented also, and also with reference to ancient Greece, a theory of sexual degeneracy. This section concludes with a discussion of the current debate in the scholarly literature of the nature of sexuality, and in particular, of homosexuality, in Greek antiquity, and notes that this discussion has inadequately integrated questions having to do with female sexuality in antiquity and modernity. (shrink)

Embark on a visual journey of self-discovery. In Beaming, Marilyne Verschueren-the artist behind internet sensation @beamingdesign-presents 100 expansive visuals designed to stimulate your mind and awaken your intuition. Messages of hope, resilience, and joy are incorporated into radiant art, with each image offering the reader an opportunity for deep contemplation and introspection. Powerful imagery is paired with 25 guided exercises for mindfulness, journaling, and breathwork to deepen your interactive experience. Full of warmth and positive energy, Beaming is an exquisite companion (...) and a stirring call to follow your truth. (shrink)

Women have historically been prevented from living autonomously by systematic injustice, subordination, and oppression. The lingering effects of these practices have prompted many feminists to view autonomy with suspicion. Here, Marilyn Friedman defends the ideal of feminist autonomy. In her eyes, behavior is autonomous if it accords with the wants, cares, values, or commitments that the actor has reaffirmed and is able to sustain in the face of opposition. By her account, autonomy is socially grounded yet also individualizing and (...) sometimes socially disruptive, qualities that can be ultimately advantageous for women. Friedman applies the concept of autonomy to domains of special interest to women. She defends the importance of autonomy in romantic love, considers how social institutions should respond to women who choose to remain in abusive relationships, and argues that liberal societies should tolerate minority cultural practices that violate women's rights so long as the women in question have chosen autonomously to live according to those practices. (shrink)

In his path-breaking study, A Colonial Liberalism: The Lost World of Three Victorian Visionaries (1991), Stuart Macintyre makes a case for the distinctiveness of colonial liberalism and its local habitat, with liberals' insistence on the principle of political equality and the democratic right of self-government. Macintyre's three visionaries — Higinbotham, Pearson and Syme — were also leading crusaders against Chinese immigration, which peaked in Victoria in the 1850s, the decade in which self-government and manhood suffrage were introduced. The local habitat (...) wore a racial aspect. In this essay I suggest that it was precisely the democratic ideal of equality, espoused in the context of Chinese immigration and colonial nation-building, that led to the insistence on racial exclusion. Colonial liberals called for racial exclusion because of, not in spite of, their commitment to democracy. The apparent paradox of a policy of exclusion promoted in the name of equality was, I suggest, definitive of the project of colonial liberalism. (shrink)

Who would the Saviour have to be, what would the Saviour have to do to rescue human beings from the meaning-destroying experiences of their lives? This book offers a systematic Christology that is at once biblical and philosophical. Starting with human radical vulnerability to horrors such as permanent pain, sadistic abuse or genocide, it develops what must be true about Christ if He is the horror-defeater who ultimately resolves all the problems affecting the human condition and Divine-human relations. Distinctive elements (...) of Marilyn McCord Adams' study are her defence of the two-natures theory, of Christ as Inner Teacher and a functional partner in human flourishing, and her arguments in favour of literal bodily resurrection and of a strong doctrine of corporeal Eucharistic presence. The book concludes that Christ is the One in Whom, not only Christian doctrine, but cosmos, church, and the human psyche hold together. (shrink)

Recent approaches towards an understanding of the molecular basis of X‐chromosome inactivation in mammals suggest that regulation is due to multiple events including DNA methylation.

In Aesthetic Legacies, Lucian Krukowski traces the influence of three nineteenth-century theories of art through twentieth-century modernism and into the postmodernist present. Following the theories of Kant, Schopenhauer, and Hegel, Krukowski first discusses how each philosopher locates the aesthetic within the framework of the philosophical system. He then identifies each theory through a dominant theme and traces the transformations of these themes into later thought and practice. The Kantian legacy originates in the theme of beauty and continues through (...) an examination of aesthetic taste into the modernist concern with artistic form. Schopenhauer's legacy moves from the dynamics of will into the themes of creative expression and artistic intentionality. Hegel's identification of art as a symbol of spirit's evolution is traced through the themes of artistic progress and cultural criticism. Krukowski interprets late modernism as a period in which the continuing transformation of aesthetic themes is arrested and congeals into dogma. This precipitates the reaction we now call postmodernism. The author first examines postmodernism through its various rejections of modernist dogma and, in the book's concluding section, evokes the alternative ideologies and practices that characterize present-day art. (shrink)

This paper explores the implications of conceptualising phenomenology as explanatory for the ongoing dialogue between the phenomenological tradition and cognitive science, especially enactive approaches to cognition. The first half of the paper offers three interlinked arguments: Firstly, that differentiating between phenomenology and the natural sciences by designating one as descriptive and the other as explanatory undermines opportunities for the kind of productive friction that is required for genuine ‘mutual enlightenment’. Secondly, that conceiving of phenomenology as descriptive rather than explanatory risks (...) committing us to what Zahavi (2019) identifies as the error of equating the phenomenological with the phenomenal. Finally, that the erroneous reduction to the descriptive occludes the rich resources that the phenomenological tradition can contribute to investigations of non-human cognition. The second half of the paper then turns to focus specifically on the promising relationship between phenomenology and enactive approaches to cognition. It will suggest that phenomenology must be seen as having explanatory capacities if it is to shed light on the structures of “mind in life” (Thompson, 2007), before drawing on the model of explanation put forward by Louis Sass to explore what this might look like. (shrink)

This book treats Hannah Arendt as a distinctly political writer who attempts to carve out a way in which humanity, poised between the Holocaust and the atom bomb, might reclaim its position as the creators of a world fit for human habitation. Marilyn LaFay argues that Arendt tries to bring a humanity into modernity, rejecting the argument that Arendt is an 'antimodernist lover of the Greek polis.' Rather, Arendt tries to politically reconcile the potential of humanity with the demands (...) of the modern condition: she encourages us to locate and use the expressive element of the modern for our political ends. This work identifies the paradox of Arendt's choice of an expressive, existentialist interpretation of politics over that of a politics of vision and imagination, concluding that Arendt's politics leads to little more than political aesthetics. (shrink)

In this paper, we examine how increasing understanding and explicit awareness of social consciousness can develop through transformations in worldview. Based on a model that emerged from a series of qualitative and quantitative studies on worldview transformation, we identify five developmental levels of social consciousness: embedded, self-reflexive, engaged, collaborative, and resonant. As a person's worldview transforms, awareness can expand to include each of these levels, leading to enhanced prosocial experiences and behaviours. Increased social consciousness can in turn stimulate further transformations (...) in worldview. We then consider an educational curriculum to facilitate the understanding of worldview and the cultivation of social consciousness as core capacities for twenty-first century students and global citizens. (shrink)

There are many ways that accountants and managers can influence the reported accounting results of their organizational units. When such influence is directed at changing the amount of reported earnings, it is known as earnings management. The purpose of this paper is to present the results of surveys of undergraduate students, MBA students, and practicing accountants concerning their attitudes on the ethical acceptability of earnings management. Analysis of the survey results reveals how the attitudes of the three groups differ and (...) what variables are associated with these differences. Based on the analysis, the authors suggest changes in accounting education curriculum and ethics awareness programs in business which might increase students'' and practitioners'' sensitivity to the ethical ramifications of earnings management. (shrink)