Osteoclasts, the multinucleated cells primarily responsible for dissolution of bone tissue, form by fusion of precursors that circulate in the bloodstream. A variety of factors have been shown to affect the mature osteoclast and its progenitor cell, such as calcium‐regulating hormones, products of the immune system, and constituents of the arachidonic acid cascade. To date, however, the osteoclast precursor has not been identified. Furthermore, there is limited information on the factors that influence osteoclast development and regulation, reflecting in part the (...) paucity of data on the osteoclast cell surface. Recent progress in understanding osteoclasts formation and function is discussed. (shrink)

This paper argues for contextualism about predicates of personal taste and evaluative predicates in general, and offers a proposal of how apparently resilient disagreements are to be explained. The present proposal is complementary to others that have been made in the recent literature. Several authors, for instance (López de Sa, 2008; Sundell, 2011; Huvenes, 2012; Marques and García-Carpintero, 2014; Marques, 2014a), have recently defended semantic contextualism for those kinds of predicates from the accusation that it faces the problem of lost (...) disagreement. These authors have proposed that a proper account of the resilient disagreement in the cases studied is to be achieved by an appeal to pragmatic processes, and to conflicting non-doxastic attitudes. It is argued here that the existing contextualist solutions are incomplete as they stand, and are subject to objections because of this. A supplementation of contextualism is offered, together with an explanation of why failed presuppositions of commonality (López de Sa), disputes over the appropriateness of a contextually salient standard (Sundell), and differences in non-doxastic attitudes (Sundell, Huvenes, Marques, and García-Carpintero) give rise to conflicts. This paper claims that conflicts of attitudes are the reason why people still have impressions of disagreement in spite of failed commonality presuppositions, that those conflicts drive metalinguistic disputes over the selection of appropriate standards, and hence conflicting non-doxastic attitudes demand an explanation that is independent of those context dependent pragmatic processes. The paper further argues that the missing explanation is 2-fold: first, disagreement prevails where the properties expressed by taste and value predicates are response-dependent properties, and, secondly, it prevails where those response-dependent properties are involved in evolved systems of coordination that respond to evolutionarily recurrent situations. (shrink)

How can we disagree with a bald-faced liar? Can we actively disagree if it is common ground that the speaker has no intent to deceive? And why do we disapprove of bald-faced liars so strongly? Bald-faced lies pose problems for accounts of lying and of assertion. Recent proposals try to defuse those problems by arguing that bald-faced lies are not really assertions, but rather performances of fiction-like scripts, or different types of language games. In this paper, I raise two objections (...) to the fictionalist view, and then offer an analysis of how we disagree with bald-faced liars. I conclude that bald-faced lies are assertions, and that in pronouncing a bald-faced lie, the speaker tries to make it common ground that the assertion was in good standing qua assertion. (shrink)

The articles collected in this symposium are result of the workshop Doing Justice to the Social, which was dedicated to the work of Sally Haslanger. The workshop took place at the Universitat Pompeu Fabra in Barcelona between the 6 and 8 June 2016. The workshop was also the 10th Meeting of the NOMOS Network for Practical Philosophy. The network meetings focus on philosophical issues connected with practical concerns, examined in an open-minded manner. This sympo- sium collects articles by Rachel Sterken, (...) Esa Díaz-León, and Jennifer Saul, and also Sally Haslanger’s reply to authors. (shrink)

The articles collected in this symposium are result of the workshop Doing Justice to the Social, which was dedicated to the work of Sally Haslanger. The workshop took place at the Universitat Pompeu Fabra in Barcelona between the 6 and 8 June 2016. The workshop was also the 10th Meeting of the NOMOS Network for Practical Philosophy. The network meetings focus on philosophical issues connected with practical concerns, examined in an open-minded manner. This sympo- sium collects articles by Rachel Sterken, (...) Esa Díaz-León, and Jennifer Saul, and also Sally Haslanger’s reply to authors. (shrink)

Tras el Pacto de Estado contra la Violencia de Género se han llevado a cabodiversas iniciativas legislativas en torno a las denominadas violencias sexualesque han desembocado en la L.O. 10/2022 de Garantía Integral de la LibertadSexual.En este trabajo se pretenden abordar dos de las cuestiones más importantesde esta Ley, el consentimiento expreso y la eliminación de la distinción entreabuso sexual y agresión sexual, todo ello, partiendo de la realidad a que sequiere dar respuesta, de las obligaciones asumidas a nivel internacional (...) ydel análisis del derecho comparado, sin olvidar la ineludible perspectiva degénero y, por su puesto, teniendo en cuenta los informes el Consejo Fiscal y elCGPJ al anteproyecto y las enmiendas presentadas al articulado del proyectopresentado el 07/07/2021. (shrink)

Temporal binding refers to a phenomenon whereby the time interval between a cause and its effect is perceived as shorter than the same interval separating two unrelated events. We examined the developmental profile of this phenomenon by comparing the performance of groups of children (aged 6-7-, 7-8-, and 9-10- years) and adults on a novel interval estimation task. In Experiment 1, participants made judgments about the time interval between i) their button press and a rocket launch, and ii) a non-causal (...) predictive signal and rocket launch. In Experiment 2, an additional causal condition was included in which participants made judgments about the interval between an experimenter’s button press and the launch of a rocket. Temporal binding was demonstrated consistently and did not change in magnitude with age: estimates of delay were shorter in causal contexts for both adults and children. Additionally, the magnitude of the binding effect was greater when participants themselves were the cause of an outcome compared to when they were mere spectators. This suggests that although causality underlies the binding effect, intentional action may modulate its magnitude. Again, this was true of both adults and children. Taken together, these results are the first to suggest that the binding effect is present and developmentally constant from childhood into adulthood. (shrink)

Este trabajo se centra en el análisis de la percepción del alumnado universitario acerca de la utilización de la metodología Flipped Classroom. Se analizarán los resultados obtenidos de una experiencia docente basada en su uso, centrándose entre otros aspectos, en la satisfacción del alumnado, la comprensión de conocimientos y adquisición de competencias, el grado de implicación de profesores/as y alumnos/as, así como las ventajas e inconvenientes percibidos. Los resultados obtenidos muestran, entre otros beneficios, la percepción de una mejora en el (...) proceso de enseñanza-aprendizaje y un aumento en la calidad de la formación, así como en la satisfacción del alumnado. (shrink)

O texto é um exercício de pensamento, a partir de textos filosóficos e de experiências vivenciadas por seu autor e sua autora, sobre a voz docente e os lugares por ela ocupados, com base em três de suas expressões que, aqui, funcionam como figuras analíticas: o grito, o gaguejo e o silêncio. Elas são tomadas a partir de sua força acontecimental e não individualizante, apontando para as forças do fora deleuziano em seu encontro com a ação docente e em suas (...) possibilidades de criação. Com tais motes vislumbram-se, ao longo do texto, gestos que narram e se propõem a ampliar reflexões sobre uma experiência de docência que, ao resistir à captura, aponta para a re-existência dos próprios professores, e para outros modos de gritar, gaguejar e silenciar. Palavras-chave: Grito; Gaguejo; Silêncio; Voz docente. Shout. Stutter. Silence. Ways of re-existing in teaching. Abstract: This text is an analytical exercise about the teaching voice and the places it occupies, based on philosophical texts and experiences lived by its authors. Three of this voice expressions function here as analytical figures: the shout, the stutter and the silence. They are taken from their event-based and non-individualizing force, pointing to the powers of the Deleuzian outside in their encounter with the teaching action and in their possibilities of creation. Gestures that narrate and propose to expand reflections on a teaching experience can be glimpsed throughout the text. They are based on a way of teaching experience that, by resisting capture, points to the re-existence of the teachers themselves, and to other ways of shouting, stuttering and silencing. Keywords: Scream; Stutter; Silence; Teachers voice. Grito. Tartamudeo. Silencio. Modos de reexistir en la docencia. Resumen: El texto es un ejercicio de reflexión, a partir de textos filosóficos y experiencias vividas por sus autores, sobre la voz docente y los lugares que ocupa a partir de tres de sus expresiones que, aquí, funcionan como figuras analíticas: el grito, el tartamudeo y el silencio. Tales expresiones son analizadas desde su fuerza acontecimiental y no individualizadora, y apuntan a las fuerzas del “afuera” deleuziano en su encuentro con la acción docente y en sus posibilidades de creación. Desde ahí se vislumbran a lo largo del texto gestos que narran y proponen ampliar reflexiones sobre una experiencia docente, que, al resistirse a la captura, apunta a la reexistencia de los propios docentes, y a otras formas de gritar, tartamudear y silenciar. Palabras-clave: Grito; Tartamudeo; Silencio; Voz docente. Data de registro: 25/04/2022 Data de aceite: 26/10/2022. (shrink)

Background: Serious games have shown positive results in increasing motivation, adherence to treatment and strengthening the therapeutic alliance in multiple psychiatric disorders. In particular, patients with impulse control disorders and other disorders in which the patient suffers from inhibitory control deficits have been shown to benefit from serious games.Aim: The aim of this study was to describe the characteristics and to evaluate the usability of a new serious videogame, e-Estesia. This serious videogame was designed to improve emotion regulation in patients (...) with gambling disorder. Preliminary results from a pilot sample are also reported.Method: A pilot sample of 26 patients undergoing treatment for GD was recruited. Participants used e-Estesia on a tablet, which was connected to a thoracic band that sent heart rate and heart rate variability data to the videogame platform in order to provide biofeedback. The System Usability Scale was completed by patients to determine the usability of e-Estesia.Results and Discussion: e-Estesia performed comparatively well for all the explored groups. Around 84.6% of the patients endorsed that it was easy to use. Female patients with GD presented higher HRV during the use of the serious videogame compared to men. (shrink)

The purpose of this article has been to show what social sciences can contribute to advance in the knowledge and understanding of personal and social problems derived from suffering from rare vision diseases. It concludes that the incorporation of data in the National Patient Registries is an opportunity to encourage research into the problems existing in our social and cultural context, in the search for solutions that will lead to improvements in treatment, health care, psycho-social care, education, employment, etc. and (...) in the evaluation of results. In short, in the conditions and quality of life of patients and their families. (shrink)

João Galrão, fundador de uma das mais importantes oficinas tipográficas na Lisboa do século XVII, possuía quatro marcas tipográficas, as quais apresentam como característica comum a presença das suas iniciais – IG. Se muitas das espécies produzidas na oficina de João Galrão ostentam, no rosto ou no cólofon, a marca do impressor, após a sua morte, a situação altera-se. António Pedroso Galrão, sobrinho e continuador do impressor João Galrão, utilizou, até meados do século XVIII, o material tipográfico da oficina de (...) seu tio, reduzindo as marcas tipográficas a uma função meramente decorativa. Curiosamente, em contrafacções estampadas na sua oficina tipográfica, não se coibiu de as utilizar, deixando a sua marca identificadora. (shrink)

In this paper I firstly examine the contents of Escur. Φ III 11, which includes a medical section, an anthology of texts both sacred and profane, and the epistolar exchange between Gregorius Acindynus and Eirene Choumnos. Secondly I go through Eirene’s intellectual background and the books transcribed under her patronage. Thirdly I explain the role played by this Escurialensis in Eirene’s library and in the anti-Palamite circles. Fourthly, basing on different kinds of arguments, I attribute the copying of ff. 83r-156v (...) to Matthew Blastares. (shrink)

This symposium explores the well-being of Latinx farmworkers living and laboring in the United States. Our primary aim is to take a deeper look at the lived experiences of farmworkers. In the introduction, we explore the various ways in which well-being is framed in diverse academic disciplines, and how the concept of well-being has been employed in previous research on Latinx farmworkers. We argue that ethnographic methods have potential to represent farmworker experiences in a more nuanced manner than many other (...) social science approaches. We advocate further research and action in terms of farmworker safety, health (including mental health and access to care), food security and food provisioning, rural isolation and access to housing, poverty and job security. Finally, we argue that farmworkers should be considered active and important actors in the context of global environmental change. Ultimately, the well-being of farmworkers is co-dependent on global environmental health and sustainability. (shrink)

This article presents a summary of the key aspects of the Biocentric theory of psychology proposed and developed by Nathaniel Branden. The themes of the conscious and nonconscious aspects of the mind and their interplay in healthy and psychopathological human functioning are highlighted, with the development and maintenance of self-esteem as the centerpiece of this schema. Branden's cogent, in-depth analysis and synthesis of these issues, presented for the first time over fifty years ago, is discussed in relation to issues that (...) are being actively researched today. (shrink)

Este artículo interpreta los vínculos entre espacio y memoria en la novela El sistema del tacto(2018) de Alejandra Costamagna a partir de la configuración de una geografía afectiva del Cono Sur, un imaginario de provincia argentina y un archivo familiar de la migración. La emergencia de un imaginario territorial que incluye el cruce transadino, el recorrido por la pampa y la ciudad provinciana de Campana proyecta distintas formas de vida social transformadas en el tiempo. Estos imaginarios se elaboran tanto desde (...) una figura de infancia que despliega una percepción particular del paisaje natural como desde una subjetividad que en el presente narrativa retorna para constatar la caducidad de las formas de vivir y habitar del siglo XX. La novela integra aspectos espaciales, materiales y lingüísticos en la conformación de distintas experiencias, imágenes y percepciones del entorno. (shrink)

I explore options for a plenitudinarian solution to the Paradox of Flexible Origin Essentialism, taking as my unlikely starting point the views of Sarah-Jane Leslie, who holds that if plenitudinarianism is true, then there is in fact no paradox to be solved, only the illusion of one. The first three sections are expository: Sect. 1 on plenitudinarianism, Sect. 2 on the paradox, and Sect. 3 on Leslie’s views about how plenitudinarianism bears on the paradox. In Sect. 4, I reject the (...) contention that there is no paradox and critically explore three options for a plenitudinarian solution. In Sect. 5, I argue that the plenitudinarian ought to endorse a fourth option. In Sect. 6, I consider an objection. I endorse neither plenitudinarianism nor its denial; the main aim of the paper is to argue that for one who does endorse plenitudinarianism, the best solution to the Paradox of Flexible Origin Essentialism is clear. (shrink)

Las reflexiones sobre la equidad de John Rawls, Amartya Sen y aun de John Stuart Mill resumidas en este artículo, muestran las graves carencias de la economía al suponer que todos los agentes tienen una única racionalidad, y que el mercado resuelve automáticamente la inequidad haciendo innecesaria una justicia distributiva, como lo afirmara recientemente Robert Nozick. La exclusión de la ética en las reflexiones actuales de la economía tiene su origen en una lectura incompleta y tendenciosa de autores como Adam (...) Smith, John Stuart Mill o León Walras, para quienes la economía era un discurso moral y no mera técnica para llegar a una asignación eficiente de los bienes sociales y, por lo tanto, hoy es urgente la tarea de vincular nuevamente la economía con la ética basada en el consenso, para atender los reclamos de una justicia distributiva. (shrink)

The article analyses the public policy of vaccination against the human papilloma virus according to the three classical criteria of need, efficacy and safety as an exemplary case of how the big transnational corporations operate and how the governments serve their interests. It discusses the changes in policy in Japan and the recent developments in France and the grass-roots movements in Spain that are organizing to change this policy. The four Lacanian discourses are applied to the analysis of the rhetoric (...) of public health authorities. (shrink)

This book focuses on dialog from a varied combination of fields: Linguistics, Philosophy of Language and Computation. It builds on the hypothesis that meaning in human communication arises at the discourse level rather than at the word level. The book offers a complex analytical framework and integration of the central areas of research around human communication. The content revolves around meaning but it also gives evidence of the connection among different points of view. Besides discussing issues of general interest to (...) the field, the book triggers theoretical argumentation that is currently under scientific discussion. It examines such topics as immanent reasoning joined with Recanati's lekta and free enrichment, challenges of internet conversation, inner dialogs, cognition and language, and the relation between assertion and denial. It proposes a dialogical framework for intra-negotiation and gives a geolinguistic perspective on spoken discourse. Finally, it examines dialog and abduction and sheds light on a generation of dialog contexts by means of multimodal logic applied to speech acts. (shrink)

This book is a call to expand and diversify our approach to the study of the human mind in relation to the Theory of Mind. It proposes that it is necessary to combine cross-disciplinary methods to arrive at a more complete understanding of how our minds work. Seeking to expand the discussion surrounding the Theory of Mind beyond the field of psychology, and its focus on our capacity to ascribe mental states to other people, this volume collects evidence and research (...) to point to a more holistic understanding of our own minds, the minds of others, behavior, language, and reasoning. This book therefore illuminates the conceptual intricacy underlying the Theory of Mind. It posits that a wide scope is necessary to make a breakthrough in scientific research towards a full understanding of the nature, function, and development of our capacity to converge on biological processes of the brain towards consciousness, emotion, awareness, and cognition. The volume presents methods, results, critiques, and models intended to provoke debates in various academic disciplines. It is of interest to scholars working in psychology, neuroscience, philosophy of mind, and artificial intelligence. (shrink)

El presente artículo tiene el objetivo de reflexionar sobre los elementos que pueden constituir un modelo de crítica cultural feminista, pensado desde la intersección entre el campo de los estudios feministas y los estudios culturales críticos, con el ánimo de abonar a la discusión sobre el “giro cultural” del feminismo en Latinoamérica. Para ello, se visitan textos clásicos de los citados campos para dar un sentido histórico y epistemológico a la propuesta y se apuesta narrativa y políticamente por un ejercicio (...) de “fabulación”, en el cual se hace una metáfora de lo que significa “hacer trabajar la cultura”, desde posicionamientos feministas, por medio de la novela La historia sin fin (1979), de Michael Ende, argumentando que la defensa de Fantasía equivale a dotarnos de otros marcos de inteligibilidad, de otros paradigmas de pensamiento y acción, que aborden de frente la pregunta por el poder y se comprometan con proyectos de transformación social, en contextos específicos. (shrink)