Due to the variation, contingency and complexity of living systems, biology is often taken to be a science without fundamental theories, laws or general principles. I revisit this question in light of the quest for design principles in systems biology and show that different views can be reconciled if we distinguish between different types of generality. The philosophical literature has primarily focused on generality of specific models or explanations, or on the heuristic role of abstraction. This paper takes a (...) different approach in emphasizing a theory-constituting role of general principles. Design principles signify general dependencyrelations between structures and functions, given a set of formally defined constraints. I contend that design principles increase our understanding of living systems by relating specific models to general types. The categorization of types is based on a delineation of the scope of biological possibilities, which serves to identify and define the generic features of classes of systems. To characterize the basis for general principles through generic abstraction and reasoning about possibility spaces, I coin the term constraint-based generality. I show that constraintbased generality is distinct from other types of generality in biology, and argue that general principles play a unifying role that does not entail theory reduction. (shrink)

Although in the last decades increasingly more philosophers have paid attention to the life sciences, traditionally physics has dominated general philosophy of science. Does a focus on the life sciences and medicine produce a different philosophy of science and indeed a different conception of knowledge? Here Cristina Chimisso does not attempt to give a comprehensive answer to this question; rather, she presents a case study focussed on Georges Canguilhem. Canguilhem continued the philosophical tradition that we now call (...) historical epistemology, and always referred very closely to the philosophy of Gaston Bachelard. However, whereas Bachelard primarily studied the history of chemistry and physics, Canguilhem turned to the life sciences, medicine and psychiatry. Chimisso investigates their respective conceptions and uses of norms. Chimisso argues that some crucial differences in how they regarded norms, seldom emphasised by Canguilhem himself and indeed by critics, stem from the sciences on which they concentrated. (shrink)

This paper criticizes the role of intuition-based ascriptions of cognition that are closely related to the ascription of mind. This practice hinders the explication of a clear and stable target domain for the cognitive sciences. To move forward, the proposal is to cut the notion of cognition free from such ascriptions and the intuition-based judgments that drive them. Instead, cognition is reinterpreted and developed as a scientific concept that is tied to a material domain of research. In this reading, cognition (...) becomes a changeable theoretical concept that can and must be adapted to the findings within this target domain. Taking humans as the best-established existing example of the relevant material target domain, this central case is extended to include all living systems. To clarify what it is about living systems that warrants their role as cognitive target domain, the new concept of cobolism is introduced as a complement to metabolism. Cobolism refers to the systematic ways in which each living system encompasses structures, processes and external events that maintain the fundamental metabolic processes that constitute the core of each living system. Cobolism is perfectly general, applies to bacterial and human cases alike, and provides a general format to describe wildly different cognitive organizations. It provides a clear target for the cognitive sciences to work on, turning them into what we can call the cognitive life sciences. (shrink)

Bringing together scholars from philosophy, bioethics, law, sociology, and anthropology, this topical collection explores how innovations in the field of biomedicine and the life sciences are challenging and transforming traditional understandings of human temporality and of the temporal duration, extension and structure of human life. The contributions aim to expand the theoretical debate by highlighting the significance of time and human temporality in different discourses and practical contexts, and developing concrete, empirically informed, and culturally sensitive perspectives. The collection (...) is structured around three main foci: the beginning of life, the middle of life, and later life. This structure facilitates an in-depth examination of specific technological and biographical contexts and at the same time allows an overarching comparison of relevant similarities and differences between life phases and fields of application. (shrink)

The purpose of this study is to examine how trends in the use of images in modern life science journals have changed since the spread of computer-based visual and imaging technology. To this end, a new classification system was constructed to analyze how the graphics of a scientific journal have changed over the years. The focus was on one international peer-reviewed journal in life sciences, Cell, which was founded in 1974, whereby 1725 figures and 160 tables from the (...) research articles in Cell were sampled. The unit of classification was defined as a graphic and the figures and tables were divided into 5952 graphics. These graphics were further classified into hierarchical categories, and the data in each category were aggregated every five years. The following categories were observed: data graphics, explanation graphics, and hybrid graphics. Data graphics increased by more than sixfold between 1974 and 2014, and some types of data graphics including mechanical reproduction images and bar charts displayed notable changes. The representation of explanatory graphics changed from hand-painted illustrations to diagrams of Bezier-curves. It is suggested that in addition to the development of experimental technologies such as fluorescent microscopy and big data analysis, continuously evolving application software for image creation and researchers’ motivation to convince reviewers and editors have influenced these changes. (shrink)

Where humans can manipulate and integrate the information they receive in subtle and ever-changing ways from context to context, computers need structured and context-free background information of a sort which ontologies can help to provide. A domain ontology captures the stable, highly general and commonly accepted core knowledge for an application domain. The domain at issue here is that of the life sciences, in particular molecular biology and bioinformatics. Contemporary life science research includes components drawn from physics, (...) chemistry, mathematics, medicine and many other areas, and all of these dimensions, as well as fundamental philosophical issues, must be taken into account in the construction of a domain ontology. Here we describe the basic features of domain ontologies in the life sciences and show how they can be used. (shrink)

This article presents an artistic and political experiment as an effort to advance democratic transactions in the life sciences. Artists built a ‘gender democratic labyrinth’ in Maastricht, in which scientists, women’s groups, people in general, artists, philosophers, politicians, journalists, clinical geneticists and many others interacted and negotiated on the creation of human embryos for medical-scientific research. By taking a gender perspective on the process of democratizing science, we aimed to create a space in which alterity and difference are (...) constitutive elements in the public exchanges on science and technology. The idea to build a labyrinth was theoretically based on the notion of agonistic democracy - in which pluralism is the result of contestations and divisions - and on a notion of science and technology as being contextualized and socialized. (shrink)

The history of twentieth-century life sciences is not exactly a new topic. However, in view of the increasingly rapid development of the life sciences themselves over the past decades, some of the well-established narratives are worth revisiting. Taking stock of where we stand on these issues was the aim of a conference in 2015, entitled “Perspectives for the History of Life Sciences”. The papers in this topical collection are based on work presented and discussed at and around (...) this meeting. Just as the conference, the collection aims at exploring fields in the history of life sciences that appear understudied, sources that have been overlooked, and novel ways of engaging with this material. The papers convened in this collection may not be representative of the field as a whole; but we feel that they do indicate some elements that have received emphasis in recent years, and may become more central in the years to come, such as the history of previously neglected contexts and domains of the life sciences, the question of continuity and change on the level of practices, the history of complexity and diversity in twentieth-century life sciences and the reconsideration of the relationship between history and philosophy of life sciences. (shrink)

Metaphors used to describe new technologies mediate public understanding of the innovations. Analyzing the linguistic, rhetorical, and affective aspects of these metaphors opens the range of issues available for bioethical scrutiny and increases public accountability. This article shows how such a multidisciplinary approach can be useful by looking at a set of texts about one issue, the use of a newly developed technique for genetic modification, CRISPRcas9.

In what follows, I suggest that it makes good sense to think of the truth of the probabilistic generalizations made in the life sciences as metaphysically grounded in stochastic mechanisms in the world. To further understand these stochastic mechanisms, I take the general characterization of mechanism offered by MDC :1–25, 2000) and explore how it fits with several of the going philosophical accounts of chance: subjectivism, frequentism, Lewisian best-systems, and propensity. I argue that neither subjectivism, frequentism, nor a (...) best-system-style interpretation of chance will give us what we need from an account of stochastic mechanism, but some version of propensity theory can. I then draw a few important lessons from recent propensity interpretations of fitness in order to present a novel propensity interpretation of stochastic mechanism according to which stochastic mechanisms are thought to have probabilistic propensities to produce certain outcomes over others. This understanding of stochastic mechanism, once fully fleshed-out, provides the benefits of allowing the stochasticity of a particular mechanism to be an objective property in the world, a property investigable by science, a way of quantifying the stochasticity of a particular mechanism, and a way to avoid a problematic commitment to the causal efficacy of propensities. (shrink)

This paper challenges the common assumption that some phenotypic traits are quantitative while others are qualitative. The distinction between these two kinds of traits is widely influential in biological and biomedical research as well as in scientific education and communication. This is probably due to both historical and epistemological reasons. However, the quantitative/qualitative distinction involves a variety of simplifications on the genetic causes of phenotypic variability and on the development of complex traits. Here, I examine three cases from the (...) class='Hi'>life sciences that show inconsistencies in the distinction: Mendelian traits, Mendelian diseases, and polygenic mental disorders. I show that these traits can be framed both quantitatively and qualitatively depending, for instance, on the methods through which they are investigated and on specific epistemic purposes. This suggests that the received view of quantitative and qualitative traits has a limited heuristic power—limited to some local contexts or to the specific methodologies adopted. Throughout the paper, I provide directions for framing phenotypes beyond the quantitative/qualitative distinction. I conclude by pointing at the necessity of developing a principled characterisation of what phenotypic traits, in general, are. (shrink)

Over the course of the last three decades, computer simulations have become a major tool of doing science and engaging with the world, not least in an effort to predict and intervene in a future to come. Born in the context of the Second World War and the discipline of physics, simulations have long spread into most diverse fields of enquiry and technological application. This paper introduces a topical collection focussing on simulations in the life sciences. Echoing the current (...) state of tinkering, fast developments, segmentation of knowledge and interdisciplinary collaboration, and in an effort to bridge the science-humanities divide, the contributors to this collection come from multiple disciplinary backgrounds, including information studies, cognitive sciences, philosophy and biology. The ambiguous character of simulations, their cutting across scientific disciplines, analysis and prediction, understanding and doing, gave rise to their success in contemporary life sciences and has been the object of much scientific debate. One of the main aims of this topical collection, by contrast, is to call into question the assumption of an obvious use and easy transfer of methods between fields of knowledge as diverse as, e.g. physics and biology. The collection presents historical case studies from various biological sub-fields. The articles study how simulations are used and the ways they contribute specifically to our understanding of life. Taking up Sergio Sismondo’s description of simulations as “compromises” and “glue”, they also critically engage with the question of what exactly the life sciences have been gluing together over the last two decades. (shrink)

This volume reviews examples and notions of robustness at several levels of biological organization. It tackles many philosophical and conceptual issues and casts an outlook on the future challenges of robustness studies in the context of a practice-oriented philosophy of science. The focus of discussion is on concrete case studies. These highlight the necessity of a level-dependent description of robust biological behaviors.Experts from the neurosciences, biochemistry, ecology, biology, and the history and the philosophy of life sciences provide a multiplex (...) perspective on the topic. Contributions span from protein folding, to cell-level robustness, to organismal and developmental robustness, to sensorimotor systems, up to the robustness of ecological systems.Several chapters detail neurobiological case-studies. The brain, the poster child of plasticity in biology, offers multiple examples of robustness. Neurobiology explores the importance of temporal organization and multiscalarity in making this robustness-with-plasticity possible. The discussion also includes structures well beyond the brain, such as muscles and the complex feedback loops involved in the peculiar robustness of music perception. Overall, the volume grounds general reflections upon concrete case studies, opening to all the life sciences but also to non-biological and bio-inspired fields such as post-modern engineering. It will appeal to researchers, students, as well as non-expert readers. (shrink)

This Open Access book combines philosophical and historical analysis of various forms of alternatives to mechanism and mechanistic explanation, focusing on the 19th century to the present. It addresses vitalism, organicism and responses to materialism and its relevance to current biological science. In doing so, it promotes dialogue and discussion about the historical and philosophical importance of vitalism and other non-mechanistic conceptions of life. It points towards the integration of genomic science into the broader history of biology. It details (...) a broad engagement with a variety of nineteenth, twentieth and twenty-first century vitalisms and conceptions of life. In addition, it discusses important threads in the history of concepts in the United States and Europe, including charting new reception histories in eastern and south-eastern Europe. While vitalism, organicism and similar epistemologies are often the concern of specialists in the history and philosophy of biology and of historians of ideas, the range of the contributions as well as the geographical and temporal scope of the volume allows for it to appeal to the historian of science and the historian of biology generally. (shrink)

In the chapter on Observing Reason in the Phenomenology, as well as in §368 of the Philosophy of Nature, Hegel deals with the life sciences of his time. There, he labels the methodology of its representatives, namely zoology and comparative anatomy, as external teleology. In this paper I want to show that by doing so he is actually discussing a general kind of functionalism. Thereby, I want to highlight a line of thought in Hegel's texts which represents a (...) productive reading of external teleology contrary to a destructive reading on which scholars have mainly focussed. (shrink)

This essay surveys the situation of Italian women life scientists from the late nineteenth to the mid-twentieth century. It follows the path that took women from being an exceptional presence to becoming a common, yet not equal, presence in the Italian science departments. Very different proportions of women occupied the three ranks in the academic hierarchy—students, research staff and professors. From the late nineteenth century onwards, women started to enrol in Italian universities. Initially, the second most popular department among (...) female students—outdone only by the humanities—was that of mathematics, physics and natural sciences. Concerning women among research staff, a brief statistical analysis reveals the growing proportion of the female workforce in academic institutions and brings into view poorly known female assistants and technicians. The most difficult career step for women was to gain a tenured university position. A comparison between bacteriologist Giuseppina Cattani’s ‘failure’ to gain such a position and the ultimately successful strategy of zoologist and limnologist Rina Monti, who became one of the very first female university professors in Europe, illustrates the opportunities as well as the obstacles women naturalists encountered on the way into the academia. These experiences and those of others show that well into the twentieth century the support of powerful male mentors continued to be indispensable for women scientists. Positions in peripheral institutes or specializations in emerging research fields, in particular hydrobiology, entomology and cytogenetics, provided opportunities for Italian women to work their way up to professorships. (shrink)

Building on group discussions and interviews with life science researchers in Austria, this paper analyses the narratives that researchers use in describing what they feel responsible for, with a particular focus on how they perceive the societal responsibilities of their research. Our analysis shows that the core narratives used by the life scientists participating in this study continue to be informed by the linear model of innovation. This makes it challenging for more complex innovation models [such as responsible (...) research and innovation ] to gain ground in how researchers make sense of and conduct their research. Furthermore, the paper shows that the life scientists were not easily able to imagine specific practices that would address broader societal concerns and thus found it hard to integrate the latter into their core responsibilities. Linked to this, researchers saw institutional reward structures as strongly focused on scientific excellence. Thus, they saw reward structures as competing with—rather than incentivising—broader notions of societal responsibility. This narrative framing of societal responsibilities is indicative of a structural marginalisation of responsibility practices and explains the claim, made by many researchers in our sample, that they cannot afford to spend time on such practices. The paper thus concludes that the core ideas of RRI stand in tension with predominant narrative and institutional infrastructures that researchers draw on to attribute meaning to their research practices. This suggests that scientific institutions still have a core role to play in providing new and context-specific narratives as well as new forms of valuing responsibility practices. (shrink)

BackgroundInformed consent forms for clinical research are several and variable at international, national and local levels. According to the literature, they are often unclear and poorly understood by participants. Within the H2020 project CORBEL—Coordinated Research Infrastructures Building Enduring Life-science Services—clinical researchers, researchers in ethical, social, and legal issues, experts in planning and management of clinical studies, clinicians, researchers in citizen involvement and public engagement worked together to provide a minimum set of requirements for informed consent in clinical studies.MethodsThe template (...) was based on a literature review including systematic reviews and guidelines searched on PubMed, Embase, Cochrane Library, NICE, SIGN, GIN, and Clearinghouse databases, and on comparison of templates gathered through an extensive search on the websites of research institutes, national and international agencies, and international initiatives. We discussed the draft versions step-by-step and then we referred to it as the “matrix” to underline its modular character and indicate that it allows adaptation to the context in which it will be used. The matrix was revised by representatives of two international patient groups.ResultsThe matrix covers the process of ensuring that the appropriate information, context and setting are provided so that the participant can give truly informed consent. It addresses the key topics and proposes wording on how to clarify the meaning of placebo and of non-inferiority studies, the importance of individual participants’ data sharing, and the impossibility of knowing in advance how the data might be used in future studies. Finally, it presents general suggestions on wording, format, and length of the information sheet.ConclusionsThe matrix underlines the importance of improving the process of communication, its proper conditions (space, time, setting), and addresses the participants’ lack of knowledge on how clinical research is conducted. It can be easily applied to a specific setting and could be a useful tool to identify the appropriate informed consent format for any study. The matrix is mainly intended to support multicentre interventional randomized clinical studies, but several suggestions also apply to non-interventional research. (shrink)

Hans Jonas’ “philosophical biology,” although developed several decades ago, is still fundamental to the contemporary reflection upon the meaning of life in a systems thinking perspective. Jonas, in fact, closely examines the reasons of modern science, and especially of Wiener’s Cybernetics and Bertalanffy’s General System Theory, and at the same time points out their basic limits, such as their having a reductionistic attitude to knowledge and ontology. In particular, the philosopher highlights the problematic consequences of scientific reductionism for (...) human nature. As the final result of an overall process of naturalization, the essence of the human being is reduced to its quantitative features only, while the “meaning” of life as such becomes no different from the “fact” of its material consistency. However, the problem is that by such a process, the human being is deprived of his specificity. (shrink)

The starting point of this PhD project is a constructivist interpretation of scientific practices: science does not study independent and pre-given phenomena, but constructs them in an active way. Although this topic has already been argued for in general, this project wants to focus on recent emerging life sciences, such as systems biology, Artificial Life and synthetic biology. These disciplines bring forth an extreme form of this constructivist aspect: they actively and explicitly produce biological phenomena, such as (...) synthetic cells that do not exist outside of the laboratories. It is, however, unclear what this ‘construction’ of nature entails. There are multiple interpretations of how to understand these technical mediations and how this constructive element either shows the uniqueness of scientific practices or precisely shows how there is nothing special about scientific practices in relation to other practices. On the one hand this project wants to identify the different interpretations of constructivism in science: what does it in fact mean to claim that science constructs its object? Secondly, it wants to differentiate the notion of constructivism itself, by abandoning it as a general claim to more local, historical claims. This allows us to differentiate how a discipline, such as synthetic biology, is constructive in a unique sense, rather than being classified merely as one illustration of constructivism. This allows us to make room for the singularity of synthetic biology: in what specific way is synthetic biology a constructive practice? (shrink)

This article, which is intended both as a position paper in the philosophical debate on natural kinds and as the guest editorial to this thematic issue, takes up the challenge posed by Ian Hacking in his paper, “Natural Kinds: Rosy Dawn, Scholastic Twilight.” Whereas a straightforward interpretation of that paper suggests that according to Hacking the concept of natural kinds should be abandoned, both in the philosophy of science and in philosophy more generally, we suggest that an alternative and less (...) fatalistic reading is also possible. We argue that abandoning the concept of natural kinds would be premature, as it still can do important work. Our concern is with the situation in the (philosophy of the) life sciences. Against the background of this concern we attempt to set something of an agenda for future research on the topic of natural kinds in the (philosophy of the) life sciences. (shrink)

The aim of this article is to detail some reservations against the beliefs, claims, or presuppositions that current essentialist natural kind concepts (including homeostatic property cluster kinds) model grouping practices in the life sciences accurately and generally. Such concepts fit reasoning into particular preconceived epistemic and semantic patterns. The ability of these patterns to fit scientific practice is often argued in support of homeostatic property cluster accounts, yet there are reasons to think that in the life sciences kind (...) concepts exhibit a diversity of grouping practices that are flattened out by conceptualizing them as natural kinds. Instead this article argues that the process of understanding grouping practices needs to start from a more neutral position independent of any ontological account. Following Love (Acta Biotheor 57:51–75, 2009) this paper suggests that typical natural kind concepts should be broached in the first place as grouping strategies that use a variety of semantic and epistemic tactics to apply group-bound information to tasks of explanation and understanding. (shrink)

Bringing together the latest scientific advances and some of the most enduring subtle philosophical puzzles and problems, this book collects original historical and contemporary sources to explore the wide range of issues surrounding the nature of life. Selections ranging from Aristotle and Descartes to Sagan and Dawkins are organised around four broad themes covering classical discussions of life, the origins and extent of natural life, contemporary artificial life creations and the definition and meaning of 'life' (...) in its most general form. Each section is preceded by an extensive introduction connecting the various ideas discussed in individual chapters and providing helpful background material for understanding them. With its interdisciplinary perspective, this fascinating collection is essential reading for scientists and philosophers interested in astrobiology, synthetic biology and the philosophy of life. (shrink)

Animal protectionists condemn speciesism for motivating the practices protectionists condemn. This misconceives both speciesism and the morality condoning those practices. Actually, animal protectionists can be and generally are speciesists. The specifically speciesist aspects of people’s beliefs are in principle compatible with all but the most radical protectionist proposals. Humanity’s speciesism is an inclusivist ideal encompassing all human beings, not an exclusionary ethos opposing moral concern for nonhumans. Anti-speciesist rhetoric is akin to anti-racist rhetoric that condemned racists for regarding people as (...) moral inferiors because of their skincolor. Actually, racists never thought that skin color is itself a reason for discounting someone’s interests, just as humans have never thought that only a human can be a proper object of moral concern. Some speciesists have great concern for animal suffering; some don’t. Animal protectionists have yet to show that a lack of concern is due to some false assumptions. (shrink)

ArgumentHere I analyze the anatomical thought of the French physician and naturalist Félix Vicq d'Azyr (1748–1794) in order to bring to light its importance in the development of comparative anatomy at the end of the eighteenth century. I argue that his work and career can be understood as an ambitious program for a radical reform of all biomedical sciences and a reorganization of this whole field around comparative anatomy, on the conceptual as well as the institutional level. In particular, he (...) recommended a close connection between anatomical and physiological studies, and a generalization of the comparative approach towards organs and functions in man and animals. This conception led him not only to reform the scope, the methods, the style of description, and the vocabulary in anatomy, but also to construct a new classification of living beings and to pursue a quest for laws of organization. This strategy was successful, since Vicq d'Azyr was able to promote his thought as well as his institutional position efficiently. The Revolution and his untimely death prevented him from achieving his program, but his attempt would serve as an example for younger scientists like Cuvier. (shrink)

Is one of the roles of theory in biology answering the question “What is life?” This is true of theory in many other fields of science. So why should not it be the case for biology? Yet efforts to identify unifying concepts and principles of life have been disappointing, leading some (pluralists) to conclude that life is not a natural kind. In this essay I argue that such judgments are premature. Life as we know it on (...) Earth today represents a single example and moreover there is positive evidence that it may be unrepresentative of life considered generally. Furthermore, as I discuss, the prototype for theorizing about life has traditionally been based on multicellular plants and animals. Yet biologists have discovered that the latter represent a rare, exotic, and fairly recent form of Earth life. By far the oldest, toughest, most extensive, and diverse form of life on our planet is unicellular, prokaryotic microbes, and there are reasons to suppose that this is almost certainly true elsewhere in the universe as well. If there are explanatorily and predictively powerful, biologically distinctive principles for life that can be gleaned from our insular example of life it is more likely that they will be found among the microbes. I discuss some provocative ways in which unicellular microbes differ from multicellular eukaryotes and argue that some of them just might provide us with key insights into the nature of life. (shrink)

Species in biology are traditionally perceived as kinds of organisms about which explanatory and predictive generalizations can be made, and biologists commonly use species in this manner. This perception of species is, however, in stark contrast with the currently accepted view that species are not kinds or classes at all, but individuals. In this paper I investigate the conditions under which the two views of species might be held simultaneously. Specifically, I ask whether upon acceptance of an ontology of species (...) as diachronic segments of the tree of life species can perform the epistemic role of kinds of organisms to which explanatory and predictive generalizations apply. I show that, for species-level segments of the tree of life, several requirements have to be met before the performance of this epistemic role is possible, and I argue that these requirements can be met by defining species according to the Composite Species Concept proposed by Kornet and McAllister in the 1990s. (shrink)

Aristotelian naturalism (AN) holds that the norms governing the human will are special instances of a broader type of normativity that is also found in other living things: natural goodness and natural defect. Both critics and defenders of AN have tended to focus on the thorny issues that are specific to human beings. But some philosophers claim that AN faces other difficulties, arguing that its broader conception of natural normativity is incompatible with current biological science. This paper has three aims. (...) First, we consider a distinctive and nuanced critique of AN’s general understanding of natural normativity put forward by Tim Lewens. Second, after giving a defense of AN, we explore and evaluate Lewens’ proposed alternative view—Kantian projectivism about life forms. We present a problem for Kantian projectivism and suggest reasons for thinking that AN is, after all, the superior position. Finally, we clarify and explain how AN’s claims about life forms and our knowledge of them, relate to empirical observation and to contemporary biological science. (shrink)

Generality is a key value in scientific discourses and practices. Throughout history, it has received a variety of meanings and of uses. This collection of original essays aims to inquire into this diversity. Through case studies taken from the history of mathematics, physics and the life sciences, the book provides evidence of different ways of understanding the general in various contexts. It aims at showing how individuals have valued generality and how they have worked with specific types of (...) "general" entities, procedures, and arguments. (shrink)

Among the more important contributions to late twentieth-century Aristotle studies was Pierre Pellegrin’s La Classification des animaux chez Aristote: Statut de la biologie et unité de l’aristotélisme, which appeared in 1982. This revisionist reading of the Historia animalium not only directed scholarly attention to Aristotle’s hitherto little-studied biological works, but it also discouraged the attempt to understand these works solely in terms of developments in modern biology. The result was a flurry of activity on the part of scholars who attempted (...) to reread the corpus in light of the biology and the biology in light of the corpus. Thus was born a new development in Aristotle studies that redirected attention toward finding unity within the corpus through the integrating value of key concepts, descriptions, and methods of the biological works. One of the best examples of this development can be found in the work of James Lennox who, over the past twenty years, has written extensively on Aristotle’s philosophy of biology. (shrink)

This rare publication continues an exploratory journey in relational biology, a study of biology in terms of the organization of networked connections in living systems. It builds on the author's two earlier monographs which looked at the epistemology of life and the ontogeny of life. Here the emphasis is on the intangibility of life, that the real nature of living systems is conveyed not by their tangible material basis but by their intangible inherent processes. Relational biology is (...) the approach that hails 'function dictates structure'; it is mathematics decoded into biological realizations. Therefore, the work begins with a concise introduction to category theory, equiping the reader with the mathematical metalanguage of relation biology. The book is organized around three parts: Part I is a comprehensive study of the most important functor in relational biology, the power set functor. The author lays the set-theoretic foundations of the functorial connections in relational biology, exploring relations, mappings, and set-valued mappings. In Part II, Natural Law receives a new mathematical formulation founded on two axioms: 'Everything is a set.' and 'Every process is a set-valued mapping.' The reader sees how Metabolism-Repair networks, equipped with set-valued processors, expand their role from models of biological entities to generic models of all natural systems. Part III expounds the various shades of invertibility in general, and the inversion of encoding to decoding in particular. A plethora of mathematical and biological examples illustrate the category-theoretic concepts of equivalence and adjunction. This book's algebraic approach to biological models will appeal to researchers and graduate students in mathematics, biology, and the philosophy of science. (shrink)

The aim of this essay is to introduce an original and radical phenomenology of life into Heidegger’s earliest lectures at Freiburg University. The motivation behind this aim lies in the exclusion of life from the existential analytic despite Heidegger’s preoccupation with the question of life during this very early period. Principally, the essay demonstrates how Husserl’s phenomenological insight into the intentionality of life has the potential to be transformed into a living aporia. Although this demonstration is (...) set within the general context of obtaining knowledge in and of life, it is achieved via a reciprocal critique of the possibility of a philosophy of life and Husserlian phenomenology to reveal the congruence life philosophy has with the project of phenomenology. In contrast to fundamental ontology, the essay ends by exposing Heidegger’s latent and inexplicit formulation of phenomenology in terms of a radical correlation that holds aporetically between living and unliving experience. (shrink)

In Science and Religious Anthropology: A Spiritually Evocative Naturalist Interpretation of Human Life, Wesley J. Wildman has awakened work in religious anthropology to a new day and a new kind of light. No one who works in religious anthropology, or in religion and science studies more generally, should be taken seriously who has not read, digested, and contended with Wildman’s work. Indeed, if one is looking for an education in genuine interdisciplinarity, in rigorous scholarly analysis and argumentation, and in (...) the ways in which academic theology, religious studies, and the scientific study of religion can mutually inform one another, Wildman’s book is the ideal school. Wildman carefully analyzes, creatively .. (shrink)

The ethics of human enhancement has been a hotly debated topic in the last 15 years. In this debate, some advocate examining science fiction stories to elucidate the ethical issues regarding the current phenomenon of human enhancement. Stories from science fiction seem well suited to analyze biomedical advances, providing some possible case studies. Of particular interest is the work of screenwriter Andrew Niccol (Gattaca, S1m0ne, In Time, and Good Kill), which often focuses on ethical questions raised by the use of (...) new technologies. Examining the movie In Time (2011), the aim of this paper is to show how science fiction can contribute to the ethical debate of human enhancement. In Time provides an interesting case study to explore what could be some of the consequences of radical life-extension technologies. In this paper, we will show how arguments regarding radical life-extension portrayed in this particular movie differ from what is found in the scientific literature. We will see how In Time gives flesh to arguments defending or rejecting radical life-extension. It articulates feelings of unease, alienation and boredom associated with this possibility. Finally, this article will conclude that science fiction movies in general, and In Time in particular, are a valuable resource for a broad and comprehensive debate about our coming future. (shrink)

The Italian philosopher Benedetto Croce (1866–1952) spent most of his life as a private scholar in Naples. His Estetica, which first appeared in 1902, has remained a seminal work not only for aesthetics but also for general linguistics. As the full title indicates, this is not a narrow work dealing with the theory of art and criticism. For Croce intended this to be the first part of his 'philosophy of the spirit' and he thus presents a systematic (...) class='Hi'>general theory intended to solve all philosophical problems. The work presents an account of the structure of the human mind and shows how art arises naturally from that structure, as well as introducing the influential notion of the organic unity of a work of art. As a result, art is shown to be integral to any life and an essential aspect of what it is to be human. (shrink)

What, precisely, are the ‘changing perspectives on reality’ in contemporary scientific thought? The topics of the lecture are the scope and the limits of science with emphasis on the physical foundations of biology. The laws of physics in general and the physics of molecules in particular form the basis for explaining the mechanism of reproduction, the generation of structure and form in the course of the development of the individual organism, the evolution of the diversity and complexity of organisms (...) by mutation and selection, and the control of behaviour by information processing in the nervous system. However, the application of scientific thought to its own foundations reveals some basic limitations in science: indeterminacy in quantum physics, the limits of decidability in mathematics, and, most likely, the limitations of an algorithmic theory of the brain-mind relationship. In all these cases, the application of scientific methods to their own presuppositions leads us to recognize their intrinsic limitations. These limits, in turn, are closely related to fundamental philosophical questions on the relationship between human knowledge and reality. Modern science is consistent with different, though of course not all, interpretations of man and the universe, including the religious interpretations of the universe as God’s creation and man as God’s (mentally creative) image. (shrink)

The Italian philosopher Benedetto Croce (1866-1952) spent most of his life as a private scholar in Naples. His Estetica, which first appeared in 1902, has remained a seminal work not only for aesthetics but also for general linguistics. As the full title indicates, this is not a narrow work dealing with the theory of art and criticism. For Croce intended this to be the first part of his "philosophy of the spirit" and he thus presents a systematic (...) class='Hi'>general theory intended to solve all philosophical problems. The work presents an account of the structure of the human mind and shows how art arises naturally from that structure, as well as introducing the influential notion of the organic unity of a work of art. As a result, art is shown to be integral to any life and an essential aspect of what it is to be human. This new translation of the first and most important part of the work (Theory) supersedes the defective translation by D. Ainslie, first published in 1909. It is based on the most recent Italian edition (1990). In his foreword the translator addresses the difficulties in translating certain key words in the Italian original, "scienza", "fantasia", and of course, "estetica" itself. He also furnishes the reader with helpful explanatory annotation. This publication will be of cardinal importance for all those interested in the philosophy of art, the history of criticism, and the history of linguistics. (shrink)

Universal laws which are shown not only in a material world, but also in spiritual, represent a crystal lattice of knowledge. This base lattice is a basis for more specific and various phenomena of our life. Various sciences study the different sides of our life. However, there are common laws for all sciences, shown both in physics, and in biology; both in chemistry, and in economy; both in psychology, and in genetics.

The aim of this paper is to elucidate the vital meaning and strategic role that nutrition holds in Claude Bernard’s “biological philosophy”, in the sense Auguste Comte gave to this expression, _i.e._ the theoretical part of biology. I propose that Bernard’s nutritive perspective on life should be thought of as an “interfield” object, following Holmes’ category. Not only does nutrition bridge disciplines like physiology and organic chemistry, as well as levels of inquiry ranging from special physiology to the organism’s (...) total level, including the cell and protoplasm, but it also forms the genetic and structural foundation for Bernard’s two fundamental axioms in general physiology: the necessary complementarity of destruction and creation (1) and the uniformity of this physiological law across all life forms, be it plants or animals (2). Because Bernard’s nutritive theory is a major pivot for the re-ordering of life and its characterization, I argue that it must be located and understood in the scientific and metaphysical context of his time, of which he claims to be the heir and challenger—what I propose to characterize as the “epistemic space” of nutrition, on the background of which Bernard builds his own “logic”. I then set out this _logic of nutrition_, focusing on three interrelated bernardian theses: the establishment of the theory of indirect nutrition as the basis for the notion of “milieu intérieur”; the enduring conception of nutrition as a continuous generation; the emphasis on nutrition as a way of reshaping the form/matter relationship. (shrink)

Here the author explains the different ways in which explanation is made. He start saying how we explain things that we don't understand in everyday life, were sometimes simple relates or ideas are enough (to explain complex things to a kid, for example), and for us, when we don't understand something, we organise our thinking in order to find a explanation which has to be intelligible, adequate and correct. In science, they are not always like that, and they start (...) trying to explain the unfamiliar things of the familiar, trying always to develop a theory of the most general kind, which will enable him to explain and predict. They are not looking for adequate, but for correct explanation, which in their case takes the form of a hipotesis. In history they behave just like in everyday life explanations, with little place for generalisations (just middle range), in intelligibility, adequacy, and correctness, because they can not venture in general theory. In conclusion, there is little to say about historical explanation which doesn't fit into everyday life explanation. (shrink)

Comparative political theory is at best an embryonic and marginalized endeavor. As practiced in most Western universities, the study of political theory generally involves a rehearsal of the canon of Western political thought from Plato to Marx. Only rarely are practitioners of political thought willing (and professionally encouraged) to transgress the canon and thereby the cultural boundaries of North America and Europe in the direction of genuine comparative investigation. Border Crossings presents an effort to remedy this situation, fully launching a (...) new era in political theory. Thirteen scholars from around the world examine the various political traditions of West, South, and East Asia and engage in a reflective cross-cultural discussion that belies the assumptions of an Asian "essence" and of an unbridgeable gulf between West and non-West. The denial of essential differences does not, however, amount to an endorsement of essential sameness. As viewed and as practiced by contributors to this ground-breaking volume, comparative political theorizing must steer a course between uniformity and radical separation--this is the path of "border crossings.". (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Mind and Life, Religion and Science: His Holiness the Dalai Lama and the Buddhism-Christianity-Science TrialogueAmos YongIn this essay, I explore what happens to the Buddhist-Christian dialogue when another party is introduced into the conversation, in this case, the sciences. My question concerns how the interface between religion and science is related to the Buddhist-Christian encounter and vice versa. I take up this question in four steps, correlating with (...) the four parts of this essay. First, I sketch a brief overview of the Buddhism-science encounter, and then turn my attention more specifically to the recent exchanges in the Mind and Life dialogues involving Western scientists and philosophers and Tibetan Buddhist practitioners, including His Holiness the Dalai Lama. Then, in our lengthiest discussion, I focus on three of the most recent books related to the Mind and Life series in order to flesh out some of the details of how Tibetan Buddhists in general and His Holiness more specifically are interacting with the sciences. Finally, I return to the larger implications that the Buddhism-science conversation has not only for the Buddhist-Christian dialogue but also potentially for the religion-science encounter.The goal of this essay is to identify the promise and the challenges involved for Buddhists and Christians when the sciences are added into the equation. I am led by a threefold hypothesis. First, the religion side of the “religion and science” dialogue needs to be further specified. Whereas it used to be the case that “religion and science” meant “Christianity and science,” no longer can or should this be assumed. Rather, there is an emerging recognition that distinctive shifts occur in the religion and science discussion when Buddhism is factored into the conversation. Second, the interreligious dialogue in general can itself benefit from engaging a third party, in this case, the natural sciences. More specifically, I am convinced that the Buddhist-Christian dialogue has much to gain when the various scientific disciplines are allowed to inform the discussion. To be sure, there will be distinctive challenges that will present themselves, not the least of which are the methodological complexities regarding the interface between religion and science added to the already complicated methodological issues that perennially beset the interreligious encounter. However it is precisely the emergent comparisons and contrasts in dialogical approaches that [End Page 43] may contribute to pushing the discussion forward. Finally, if it is the case that religion does indeed have something to contribute to its dialogue with the sciences, so much more is it the case that science may benefit not only from the separate insights of two religious traditions, but also from the cross-fertilization that occurs in the interreligious dialogue.Two caveats before proceeding with the essay. First, I speak first and foremost as a Christian theologian with academic training in the study of religion, rather than in Buddhist traditions in particular. While my Christian perspectives will inevitably color my understanding of Buddhism, I believe it is possible in this case, given the hypotheses outlined above, that such “biases” can be profitably harnessed to explore what happens when the Buddhist-Christian dialogue is enlarged to become a trialogue between Buddhism, Christianity, and the sciences. In fact, I am convinced that Christian theology for the twenty-first century needs to dialogue both with other faiths and with the sciences, and this essay is an attempt to bring these essential dialogues together.1Second, I approach the following review essay with a certain degree of fear and trembling given that in a very real sense my primary dialogue partners are Tibetan Buddhist adepts as well as His Holiness the Dalai Lama. I do not in any way intend to be presumptuous about claiming to be able to critically interact with his knowledge of Buddhism or the sciences. On the contrary, I am a mere novice and amateur in these fields of inquiry compared to his lifelong study and practice of the Buddhist tradition, and his decades-long engagement with the sciences. Yet I find encouragement from his own openness to interacting with the Christian tradition and from his willing to learn from Christians and the Christian faith.2 Further... (shrink)

Life is a compelling addition to the Darwin College Lecture Series, in which eight distinguished authors each present an essay from their area of expertise devoted to the theme of 'life'. The book forges connections between art, science and the humanities in a vibrant and thought-provoking collection that exposes both conventional and unconventional views on the meaning of life, the enigmatic boundaries between the living and the dead, and what may or may not follow afterwards. This collection (...) arises from the Darwin College Lecture Series of 2012 and includes contributions from eight distinguished scholars, all of whom are held in esteem not only for their research, but also for their ability to communicate their subject to popular audiences. (shrink)

The founder of modern linguistics, Ferdinand de Saussure inaugurated semiology, structuralism, and deconstruction and made possible the work of Jacques Derrida, Roland Barthes, Michel Foucault, and Jacques Lacan, thus enabling the development of French feminism, gender studies, New Historicism, and postcolonialism. Based on Saussure's lectures, _Course in General Linguistics_ (1916) traces the rise and fall of the historical linguistics in which Saussure was trained, the synchronic or structural linguistics with which he replaced it, and the new look of diachronic (...) linguistics that followed this change. Most important, Saussure presents the principles of a new linguistic science that includes the invention of semiology, or the theory of the "signifier," the "signified," and the "sign" that they combine to produce. This is the first critical edition of _Course in General Linguistics_ to appear in English and restores Wade Baskin's original translation of 1959, in which the terms "signifier" and "signified" are introduced into English in this precise way. Baskin renders Saussure clearly and accessibly, allowing readers to experience his shift of the theory of reference from mimesis to performance and his expansion of poetics to include all media, including the life sciences and environmentalism. An introduction situates Saussure within the history of ideas and describes the history of scholarship that made _Course in General Linguistics_ legendary. New endnotes enlarge Saussure's contexts to include literary criticism, cultural studies, and philosophy. (shrink)