Following Hannah Arendt’s insights into the affinities between Marxism and the philosophy of life, this article reconstructs a theoretical position that we propose to call ‘vitalist Marxism’. This position conceives of life not only as an essential foundation of the production process, but also as a critical resource for resistance to the capitalist logic of exploitation. We highlight the role Georges Canguilhem (1904–95) played in developing this position, in particular by depicting tools and machines as ‘organs of life’. Drawing on (...) Canguilhem’s early writings as well as unpublished manuscripts, we show that this ‘organological’ understanding of technology was rooted in the increasingly anti-fascist reception of Marx in France during the 1930s. Against the background of today’s protests against climate destruction, racism, and anti-feminist violence, all of which invoke the defense of basic living conditions, we argue that the critical position of vitalist Marxism acquires remarkable topicality. (shrink)