COVID-19 often manifests with different outcomes in different patients, highlighting the complexity of the host-pathogen interactions involved in manifestations of the disease at the molecular and cellular levels. In this paper, we propose a set of postulates and a framework for systematically understanding complex molecular host-pathogen interaction networks. Specifically, we first propose four host-pathogen interaction (HPI) postulates as the basis for understanding molecular and cellular host-pathogen interactions and their relations to disease outcomes. These four postulates cover the evolutionary dispositions involved (...) in HPIs, the dynamic nature of HPI outcomes, roles that HPI components may occupy leading to such outcomes, and HPI checkpoints that are critical for specific disease outcomes. Based on these postulates, an HPI Postulate and Ontology (HPIPO) framework is proposed to apply interoperable ontologies to systematically model and represent various granular details and knowledge within the scope of the HPI postulates, in a way that will support AI-ready data standardization, sharing, integration, and analysis. As a demonstration, the HPI postulates and the HPIPO framework were applied to study COVID-19 with the Coronavirus Infectious Disease Ontology (CIDO), leading to a novel approach to rational design of drug/vaccine cocktails aimed at interrupting processes occurring at critical host-coronavirus interaction checkpoints. Furthermore, the host-coronavirus protein-protein interactions (PPIs) relevant to COVID-19 were predicted and evaluated based on prior knowledge of curated PPIs and domain-domain interactions, and how such studies can be further explored with the HPI postulates and the HPIPO framework is discussed. (shrink)

本书从创造和思想两方面,勾勒出西方一段艺术审美的演进过程,并说明这一演进的主导轨迹。内容包括古典时期的艺术与哲学、多元文化下的艺术审美、艺术哲学的体系建构以及艺术走向现代的分流四部分。.

Emergence is a notorious philosophical term of art. A variety of theorists have appropriated it for their purposes ever since George Henry Lewes gave it a philosophical sense in his 1875 Problems of Life and Mind. We might roughly characterize the shared meaning thus: emergent entities (properties or substances) ‘arise’ out of more fundamental entities and yet are ‘novel’ or ‘irreducible’ with respect to them. (For example, it is sometimes said that consciousness is an emergent property of the brain.) Each (...) of the quoted terms is slippery in its own right, and their specifications yield the varied notions of emergence that we discuss below. There has been renewed interest in emergence within discussions of the behavior of complex systems and debates over the reconcilability of mental causation, intentionality, or consciousness with physicalism. (shrink)

According to the reports in the past decade, some Asian subcontractors, mainly Taiwan, Hong Kong and Korea transnational corporations, tend to be labor abusive in their overseas investment destinations like China or Southeast Asia. Taking Vietnam as an example, this paper raises questions as to why Taiwanese transnational companies can control workplace unions in a trade-union-supportive regime. Given the government s constraint of political rights, and the individualized workplace unions, the function of trade unions in Vietnam is destined to (...) be limited. The trade unions turn out be an arm of management, rather than representing workers interests in these transnational companies. This article also explores the influence of the newly developed codes of conducts from Western buyers. In the survey of three companies which are required to follow the codes of conduct by buyers, trade unions had no more freedom than those in companies without codes of conduct. The paper discusses the implications of this research, offering strategies for labor rights improvements. (shrink)

Although most Asian states are signatories to UNCLOS, which offers options for dispute resolution by either voluntary or compulsory processes, in reality fewer than a dozen Asian states have taken advantage of such an approach. The decision to adopt third-party mechanisms comes under great scrutiny and deliberation, not least because of the entailing legal procedures and the politically sensitive nature of disputes. Vietnam claims the second-largest maritime area in the South China Sea dispute after China. A comparison of two recent (...) cases—the arbitration between the Philippines and China and the conciliation between Timor-Leste and Australia—highlights the importance of selecting between binding and nonbinding decisions and framing a complaint. In particular, any legal action under UNCLOS should specify China’s claims and actions in areas that encroach on Vietnam’s claimed exclusive economic zone (EEZ) and violate international law. (shrink)

It has been contended that ostracism is prevalent in the workplace, and there has been increasing research interest in its potential effects. This paper extends the theoretical framework of workplace ostracism by linking it with affective commitment and intention to leave from the perspective of job embeddedness. Using time-lagged data from China, we apply job embeddedness theory to confirm that workplace ostracism decreases the cultivation of job embeddedness, which in turn undermines affective commitment and induces intention to leave. We also (...) find that intrinsic work motivation strengthens the detrimental effects of workplace ostracism on job embeddedness such that the negative relationship is stronger when intrinsic motivation is high rather than low. We further discuss the theoretical and practical implications of our findings and offer future research directions. (shrink)

本书侧重从中国古代政治史、思想史、文化史和文学史的结合方面,研究和探讨了中国古代德治思想与文士文学的关系。.

本书包括《南询录》校注记、《南询录》校注、记录邓豁渠生平的文献资料、研究邓豁渠的两篇论文这四个部分的内容。.

本书阐释了“命”论在王充的哲学体系中所起的作用,王充“气”论新议,王充“天地”论新议等内容。.

Due to the current COVID-19 pandemic, colleges and universities have implemented network teaching. E-learning engagement is the most important concern of educators and parents because this will directly affect student academic performance. Hence, this study focuses on students’ perceived family support and their e-learning engagement and analyses the effects of e-learning normative consciousness and behaviours and self-efficacy on the relationship between family support and e-learning engagement in college students. Prior to this study, the relationship between these variables was unknown. Four (...) structural equation models revealed the multiple mediating roles of e-learning normative consciousness and behaviours and self-efficacy in the relationship between family support and e-learning engagement. A total of 1317 college students (mean age = 19.51; 52.2% freshman) voluntarily participated in our study. The results showed that e-learning normative consciousness and behaviours and self-efficacy played significant and mediating roles between students’ perceived family support and their e-learning engagement. Specifically, these two individual variables fully mediated the relationship between students’ perceived family support and their e-learning engagement. The multiple mediation model showed that family members can increase family support of their children by creating a household environment conducive to learning, displaying positive emotions, demonstrating the capability to assist their children, advocating the significance of learning normative consciousness and behaviours and encouraging dedicated and efficient learning. The findings complement and extend the understanding of factors influencing student e-learning engagement. (shrink)

The relationship between Vietnam and China could be captured in the Chinese expression of “同床异梦”, which means lying on the same bed but having different dreams. The two countries share certain cultural and political similarities but also diverge vastly in their national interests. This paper adds to the extant literature on this topic by analyzing the element of trust/mistrust in their interactions in trade-investment, tourism, and defense-security. The analysis shows how the relationship is increasingly interdependent but is equally fragile due (...) to the lack of trust on both sides. The mistrust or even distrust of Chinese subjects run deep within the Vietnamese mindset, from the skepticism of Chinese investment, Chinese tourists, discrimination against ethnic Chinese, to the caution against Chinese aggression in the South China Sea. The paper forecasts that, despite the deep-seated differences and occasional mistrust, going forward, neither side would risk damaging the status quo even when tensions peak. (shrink)

Chance-based gambling has been a recurrent cultural activity throughout history and across many diverse human societies. In this paper, I combine quantitative and qualitative data and present a cultural evolutionary framework to explain why the odds in games of chance in premodern China appeared “designed” to ensure a moderate yet favorable house advantage. This is especially intriguing since extensive research in the history of probability has shown that, prior to the development of probability theory, people had very limited understanding of (...) the nature of random events and were generally disinclined to think mathematically about the frequency of their occurrence. I argue that games of chance in the context of gambling may have culturally evolved into their documented forms via a process of selective imitation and retention, and neither the customers nor the gambling houses understood the probability calculus involved in these games. (shrink)

The following framework of theses, roughly hewn, shapes contemporary discussion of the problem of mental causation: (1) Non-Identity of the Mental and the Physical Mental properties and states cannot be identified with specific physical properties and states. (2) Causal Closure (Completeness) of the Physical The objective probability of every physical event is fixed by prior physical events and laws alone. (This thesis is sometimes expressed in terms of explanation: In tracing the causal history of any physical event, one need not (...) advert to any non-physical events or laws. To the extent that there is any explanation available for a physical event, there is a complete explanation available couched entirely in physical vocabulary. We prefer the probability formulation, as it should be acceptable to any physicalist, though some reject the explanation formulation.) (3) Causal Exclusion There is at most one complete and wholly independent explanation for any given event or sequence of events. (shrink)

With the introduction of zoom and cell group Bible study and fellowship gathering with church members from 6 to 10, congregation members of each Korean church have come to appreciate the diversity within each consistory encompassing multigenerational American born Koreans, foreign expats, diplomats, immigrants from middle class and up from the greater Seoul, South Korea area, political refugees and migrant workers who categorically entered this country with Republic of Korea visa but who originally were able to date back their earlier (...) life from Communist Regimes such as Siberia, China, Vietnam and North Korea (Ibuk chulsin) and other Asian of color looking foreigners and mix-breeds with Korean heritage and other combinations. The focus of their Christian practice has been more passive concept of God’s grace grounded on John Wesley tradition rather than their yoking and making progress in lineal fashion into the future with and by believers out of Christian love. A premium is placed in smooth transitioning from static Confucianism and Christianity embracing education, meritocracy, social harmony and order. (shrink)

In September 2008, the European Organization for Nuclear Research (CERN) scientists successfully switched on the historic biggest physics device, the Large ...

Matarese (2022) argued in a commentary that Machery’s (2020) resampling account of replication (RAR) is unsatisfactory because it was too quick to abolish the distinction between direct and conceptual replications. Although Matarese agrees with Machery that some interpretations of conceptual replications are misconceived, she offers an interpretation which purports to show that direct and conceptual replications have different functions, and this justifies preserving the distinction. In this commentary, I will defend the RAR from Matarese’s argument. Most importantly, I will argue (...) that Matarese’s interpretation of conceptual replications is conceptually impossible. Thus, I conclude that the direct–conceptual distinction was rightly abolished by Machery. (shrink)

The results of the National Higher Education Entrance Examination have a life-long effect on most Chinese by labeling them clever or not. Some of the following rules of the Gaokao enhance the damage, for example, the rule of Who, What and Where. In general, Who you are and What you have done are of secondary importance, but Where you graduated from, especially the college of first-record is the most important, but discriminatory criterion in the recruitment courses of most of scientific (...) communities and social organizations in China. (shrink)

By the Riesz representation theorem for the dual of C [0; 1], if F: C [0; 1] → ℝ is a continuous linear operator, then there is a function g: [0;1] → ℝ of bounded variation such that F = ∫ f dg . The function g can be normalized such that V = ‖F ‖. In this paper we prove a computable version of this theorem. We use the framework of TTE, the representation approach to computable analysis, which allows (...) to define natural computability for a variety of operators. We show that there are a computable operator S mapping g and an upper bound of its variation to F and a computable operator S ′ mapping F and its norm to some appropriate g. (shrink)

This paper is a comparative study of two texts separated by a considerable temporal-spatial gap. The methodological approach is, as we would like to define it, a-philological. Five central concepts drawn from the Dàshèng qǐxìn lùn, traditionally associated with Aśvaghoṣa, Paramārtha, and Śikṣānanda, shall be examined against the related ideas found in Ratnākaraśānti’s Prajñāpāramitopadeśa. Our observations are the following: 1) The two dimensions of the single mind advocated in the QXL are doctrinally identical to the two forms of the dependent (...) nature in the PPU. 2) The intermingling mind which is taken as ālayavijñāna in the QXL, corresponds to the imagination of the unreal in the PPU. 3) The mutual perfuming of the real and the unreal is in essence the same as the false inseparability of clear light and image in the PPU. 4) The essence of perception and its synonyms used in the QXL, its commentarial literature and other related texts, find equivalents such as prakāśamānatā, prakāśātmatā, saṃvedyatā, buddhilakṣaṇa, in the PPU. 5) The concept of activated perception in the QXL sheds light on a puzzling word in the PPU, arvāk, which can be interpreted as the opposite of “suddenly” in the QXL. Our investigation reaffirms the philosophical value as well as the religious legitimacy of the QXL, and it underscores the significance of the late mādhyamika texts for Buddhist Studies. (shrink)

Politics has become a common element in the performance appraisal process, and as decision recipients in this process, those appraised tend to be more sensitive to performance appraisal politics. This paper examines the mechanisms by which performance appraisal politics perception affects counterproductive work behavior from the perspective of those appraised. The mediating effect of perceived organizational justice and the moderating effect of political skill are incorporated into a parsimonious moderated-mediation model. A quantitative research approach is employed with survey data from (...) 460 employees of large and medium-sized enterprises in Hubei Province, and structural equation modeling and bootstrap analysis are used to test the proposed hypothesized relationships. The findings demonstrate that PAPP has a positive impact on CWB, and POJ partly mediates the relationship between PAPP and CWB. The results also reveal that individual PS moderates the positive correlation between PAPP and CWB. The academic and practical implications of these findings, as well as limitations and suggestions for future research, are also discussed. (shrink)

本书内容包括:立法的准则、司法的尺度、司法推理的艺术、最好的论证、最好的反驳五部分。.

With the rapid development of Internet of Things technology, RFID technology has been widely used in various fields. In order to optimize the RFID system hardware deployment strategy and improve the deployment efficiency, the prediction of the RFID system identification rate has become a new challenge. In this paper, a neighborhood rough set and random forest combination model is proposed to predict the identification rate of an RFID system. Firstly, the initial influencing factors of the RFID system identification rate are (...) reduced using neighborhood rough set theory combined with the principle of heuristic attribute reduction of neighborhood weighted dependency, thus obtaining a kernel factor subset. Secondly, a random forest prediction model is established based on the kernel factor subset, and a confusion matrix is established using out-of-bag data to evaluate the prediction results. The test is conducted under the constructed RFID experimental environment, whose results showed that the model can predict the identification rate of the RFID system in a fast and efficient way, and the classification accuracy can reach 90.5%. It can effectively guide the hardware deployment and communication parameter protocol setting of the system and improve the system performance. Compared with BP neural network and other prediction models, NRS-RF has shorter prediction time and faster calculation speed. Finally, the validity of the proposed model was verified by the RFID intelligent archives management platform. (shrink)

Multisource information systems and multigranulation intuitionistic fuzzy rough sets are important extended types of Pawlak’s classical rough set model. Multigranulation intuitionistic fuzzy rough sets have been investigated in depth in recent years. However, few studies have considered this combination of multisource information systems and intuitionistic fuzzy rough sets. In this paper, we give the uncertainty measure for multisource intuitionistic fuzzy information system. Against the background of multisource intuitionistic fuzzy information system, each information source is regarded as a granularity level. Considering (...) the different importance of information sources, we assign different weights to them. Firstly, the paper proposes an optimal source selection method. Secondly, we study the weighted generalized, weighted optimistic, and weighted pessimistic multigranularity intuitionistic fuzzy rough set models and uncertainty measurement methods in the multisource intuitionistic fuzzy information system, and we further study the relationship between the three models and related properties. Finally, an example is given to verify the validity of the models and methods. (shrink)