In lieu of an abstract, here is a brief excerpt of the content:Toward a Dialectics of Emptiness: Overcoming Nihilism and Combatting Mechanization in Nishitani Keiji’s Postwar ThoughtGriffin WernerIn his postwar writings on nihilism in modernity, Nishitani Keiji (1900–90) does not explicitly articulate the structure of the relationship between the mechanization of the world and nihilism. Instead, he discusses mechanization with respect to his critique of modern worldviews such as atheism, scientism, and liberalism and how they have contributed to the advent (...) of nihilism and the loss of human autonomy in modern Europe and Japan.1 According to Nishitani, before the advent of scientism and the subsequent progression of unfettered technological development, pre-Western-Enlightenment and pre-Meiji-period worldviews consisted of a fundamental embodied connection between a people or culture and their spiritual traditions. In Europe’s case, due to the death of God and the subsequent shift from a Christian worldview to an atheistic and scientistic one, a historical period of nihilism began. Modern mechanistic worldviews like Descartes’s, Nishitani argues, present the world as consisting of dead matter that is fundamentally separated from the indubitable ego. No longer is the world considered to be “alive” in the sense of there being a fundamental connection between human life and the living, breathing world around it. Rather, from the perspective of the ego, the modern world is simply a cold and lifeless world of dead machines.As discussed in Religion and Nothingness, the development of structurally Cartesian worldviews led to or caused the advent of nihilism in Europe. Consequently, European culture lost its cultural ground in Christianity and individuals lost their foundational meaning which supported their understanding of themselves in relation [End Page 129] to others, the world, and a transcendent God. As Japan began to modernize, or, arguably, “Westernize,” it inherited a Cartesian-like worldview and, over time, subsequently lost touch with its traditional philosophical and religious ground as well. As a result, the modern period of nihilism began in both Europe and Japan as both peoples lost touch with the traditional meaning that supported them.While this description between mechanization and nihilism implies a causal relationship, I argue that the relationship between nihilism and the mechanization of the world can be more accurately articulated in terms of a dialectical relationship. In the modern context, not only does the mechanization of the world lead to or exacerbate a culture’s plunge into nihilism or an individual’s confrontation with the abyss of nihility, but nihilism also reinforces and exacerbates the mechanization of the world. As partners in this dialectical oscillation, each reinforces the other as one (culture or person) continuously spirals deeper and deeper into meaninglessness, ultimately to the culminating point that Nishitani calls the “mechanization of man.”2Just as Nishitani argues that the problem of nihilism can only be solved by way of radicalizing nihilism to the “field of emptiness,” the structural oscillation between nihilism and mechanization will continue at the levels of the individual and the culture unless nihilism and mechanization are overcome. However, rather than only overcoming nihilism to reach emptiness in the individual, and that leading to social and political change, I argue that overcoming the dialectical tension between nihilism and mechanization will require a “dialectics of emptiness.” Such a dialectic will combat nihilism and mechanization with a mutually reinforcing tension between personal transformation, which overcomes nihilism by way of stepping back to the field of emptiness, and socio-political transformation by way of a politics of emptiness. Solving the problem of nihilism in modernity—insofar as it is always already in relation to mechanization—will require more than individual existential confrontation and transformation. Through one’s individual overcoming of nihilism, one must also aim to “empty” those institutions which contribute to the mechanization of the world. While Nishitani highlights the individual’s religious quest as the impetus for the social and political change necessary to overcome the problem of nihilism at the cultural level, an analysis of how that might be done and what [End Page 130] may be politically necessary in order to do so is missing from his thought.As such, my aim in this article is twofold: I attempt to shed light on the structure of nihilism and... (shrink)

Due to the controversy surround his political war-time writings, Nishida Kitarō and his entire corpus has been accused of promoting and supporting Japanese imperialism. Despite the valid criticisms of his writings during the war-time period, Nishida’s early work in An Inquiry into the Good is not so easily interpreted as supporting nationalism. In fact, depending on the lens through which one reads Nishida’s early writings, one can even find the germs of emancipatory ideas that can easily be put in dialogue (...) with other liberatory thinkers such as Marx, Kropotkin, and Adorno. In this article, by considering the pluripotentiality of the text rather than a hermetically sealed off nationalist reading of it, I reread the ethical politics in An Inquiry into the Good through an emancipatory lens, considering how Nishida’s thought could have been taken up in a very different post-1911 Japan that did not move toward authoritarian militarism. Furthermore, I argue that the ambiguity surrounding his early political writings is consistent with his resistance to authoritarian ethics and his emphasis on the autonomy of the individual. (shrink)

Ioannidis [Why most published research findings are false. PLoS Med 2: e124 ] identifies six factors that contribute to explaining why most of the current published research findings are more likely to be false than true, and argues that for many current scientific fields, claimed research findings may often be simply accurate measures of the prevailing bias. In this article, we argue that three “hot” areas in current biological research, viz., agent-based modeling, evolutionary developmental biology , and systems biology, are (...) especially prone to the flaws. (shrink)

"Well-being," "welfare," "utility," and "quality of life," all closely related concepts, are at the center of morality, politics, law, and economics. Griffin's book, while primarily a volume of moral philosophy, is relevant to all of these subjects. Griffin offers answers to three central questions about well-being: what is the best way to understand it, can it be measured, and where should it fit in moral and political thought. With its breadth of investigation and depth of insight, this work (...) holds significance for philosophers as well as for those interested in political and economic theory and jurisprudence. (shrink)

The seminal work by one of the most important thinkers of the twentieth century, Physics and Philosophy is Werner Heisenberg's concise and accessible narrative of the revolution in modern physics, in which he played a towering role. The outgrowth of a celebrated lecture series, this book remains as relevant, provocative, and fascinating as when it was first published in 1958. A brilliant scientist whose ideas altered our perception of the universe, Heisenberg is considered the father of quantum physics; he (...) is most famous for the Uncertainty Principle, which states that quantum particles do not occupy a fixed, measurable position. His contributions remain a cornerstone of contemporary physics theory and application. Book jacket. (shrink)

Studies the central topics of Wittgenstein's philosophy prior to and within the first parts of the Tractatus, covering such subjects as objects, substance, states of affairs, elementary propositions, pictures, and thoughts. He concludes that analysis is reduction to what is basic not in experience but in reference, and argues that the Tractatus is concerned not with problems of knowledge but with problems of sense.

Ethics appears early in the life of a culture. It is not the creation of philosophers. Many philosophers today think that their job is to take the ethics of their society in hand, analyse it into parts, purge the bad ideas, and organize the good into a systematic moral theory. The philosophers' ethics that results is likely to be very different from the culture's raw ethics and, they think, being better, should replace it. But few of us, even among philosophers, (...) settle real-life moral questions by consulting the Categorical Imperative or the Principle of Utility, largely because, if we do, we often do not trust the outcome or cannot even reliably enough decide what it is. By contrast, James Griffin explores the question what philosophers can reasonably expect to contribute to normative ethics or to the ethics of a culture. Griffin argues that moral philosophers must tailor their work to what ordinary humans' motivational capabilities, and he offers a new account of moral deliberation. (shrink)

This is Werner S. Pluhar's translation of Immanuel Kant's Critique of Judgment (Kritik der Urtheilskraft) for Hackett Publications (Indianapolis, Indiana). ISBN 9780872200258 (paperback).

The contributions of few contemporary scientists have been as far reaching in their effects as those of Nobel Laureate Werner Heisenberg.

The Information Artifact Ontology (IAO) was created to serve as a domain‐neutral resource for the representation of types of information content entities (ICEs) such as documents, data‐bases, and digital im‐ages. We identify a series of problems with the current version of the IAO and suggest solutions designed to advance our understanding of the relations between ICEs and associated cognitive representations in the minds of human subjects. This requires embedding IAO in a larger framework of ontologies, including most importantly the Mental (...) Func‐tioning Ontology (MFO). It also requires a careful treatment of the aboutness relations between ICEs and associated cognitive representa‐tions and their targets in reality, which implies in turn a new treatment of the relation of truthmaking. (shrink)

The goal of referent tracking is to create an ever-growing pool of data relating to the entities existing in concrete spatiotemporal reality. In the context of Electronic Healthcare Records (EHRs) the relevant concrete entities are not only particular patients but also their parts, diseases, therapies, lesions, and so forth, insofar as these are salient to diagnosis and treatment. Within a referent tracking system, all such entities are referred to directly and explicitly, something which cannot be achieved when familiar concept-based systems (...) are used in what is called “clinical coding”. In this paper we describe the components of a referent tracking system in an informal way and we outline the procedures that would have to be followed by healthcare personnel in using such a system. We argue that the referent tracking paradigm can be introduced with only minor – though nevertheless ontologically important – technical changes to existing EHR infrastructures, but that it will require a radically different mindset on the part of those involved in clinical coding and terminology development from that which has prevailed hitherto. (shrink)

While classifications of mental disorders have existed for over one hundred years, it still remains unspecified what terms such as 'mental disorder', 'disease' and 'illness' might actually denote. While ontologies have been called in aid to address this shortfall since the GALEN project of the early 1990s, most attempts thus far have sought to provide a formal description of the structure of some pre-existing terminology or classification, rather than of the corresponding structures and processes on the side of the patient. (...) We here present a view of mental disease that is based on ontological realism and which follows the principles embodied in Basic Formal Ontology and in the application of BFO in the Ontology of General Medical Science. We analyzed statements about what counts as a mental disease provided in the research agenda for the DSM-V, and in Pies' model. The results were used to assess whether the representational units of BFO and OGMS were adequate as foundations for a formal representation of the entities in reality that these statements attempt to describe. We then analyzed the representational units specific to mental disease and provided corresponding definitions. Our key contributions lie in the identification of confusions and conflations in the existing terminology of mental disease and in providing what we believe is a framework for the sort of clear and unambiguous reference to entities on the side of the patient that is needed in order to avoid these confusions in the future. (shrink)

Quality assurance in large terminologies is a difficult issue. We present two algorithms that can help terminology developers and users to identify potential mistakes. We demon­strate the methodology by outlining the different types of mistakes that are found when the algorithms are applied to SNOMED-CT. On the basis of the results, we argue that both formal logical and linguistic tools should be used in the development and quality-assurance process of large terminologies.

PURPOSE—A substantial fraction of the observations made by clinicians and entered into patient records are expressed by means of negation or by using terms which contain negative qualifiers (as in “absence of pulse” or “surgical procedure not performed”). This seems at first sight to present problems for ontologies, terminologies and data repositories that adhere to a realist view and thus reject any reference to putative non-existing entities. Basic Formal Ontology (BFO) and Referent Tracking (RT) are examples of such paradigms. The (...) purpose of the research here described was to test a proposal to capture negative findings in electronic health record systems based on BFO and RT. METHODS—We analysed a series of negative findings encountered in 748 sentences taken from 41 patient charts. We classified the phenomena described in terms of the various top-level categories and relations defined in BFO, taking into account the role of negation in the corresponding descriptions. We also studied terms from SNOMED-CT containing one or other form of negation. We then explored ways to represent the described phenomena by means of the types of representational units available to realist ontologies such as BFO. RESULTS—We introduced a new family of ‘lacks’ relations into the OBO Relation Ontology. The relation lacks_part, for example, defined in terms of the positive relation part_of, holds between a particular p and a universal U when p has no instance of U as part. Since p and U both exist, assertions involving ‘lacks_part’ and its cognates meet the requirements of positivity. CONCLUSION—By expanding the OBO Relation Ontology, we were able to accommodate nearly all occurrences of negative findings in the sample studied. (shrink)

Ontology is currently perceived as the solution of first resort for all problems related to biomedical terminology, and the use of description logics is seen as a minimal requirement on adequate ontology-based systems. Contrary to common conceptions, however, description logics alone are not able to prevent incorrect representations; this is because they do not come with a theory indicating what is computed by using them, just as classical arithmetic does not tell us anything about the entities that are added or (...) subtracted. In this paper we shall show that ontology is indeed an essential part of any solution to the problems of medical terminology – but only if it is understood in the right sort of way. Ontological engineering, we shall argue, should in every case go hand in hand with a sound ontological theory. (shrink)

Based on the Ontology for General Medical Science, we propose definitions for biomarkers of various types of. These definitions provide not only a complete formal representation of what biomarkers are according to the Institute of Medicine (IOM), but also remove the ambiguities and inconsistencies encountered in the documentation provided by the IOM.

Examines the postmodern implications of Whitehead’s metaphysical system.

Wittgenstein expounds his notion of a family resemblance in two important passages. The first is from The Blue Book:This craving for generality is the resultant of a number of tendencies connected with particular philosophical confusions. There is— The tendency to look for something common to entities which we commonly subsume under a general term. We are inclined to think that there must be something common to all games, say, and that this common property is the justification for applying the general (...) term “game” to the various games; whereas the games form a family the members of which have family likenesses …. There is a tendency rooted in our usual forms of expression, to think that a man who has learnt to understand a general term, say, the term “leaf,” has thereby come to possess a kind of general picture of a leaf, as opposed to pictures of particular leaves …. This again is connected with the idea that the meaning of a word is an image, or a thing correlated with the word. (shrink)

We present the details of a methodology for quality assurance in large medical terminologies and describe three algorithms that can help terminology developers and users to identify potential mistakes. The methodology is based in part on linguistic criteria and in part on logical and ontological principles governing sound classifications. We conclude by outlining the results of applying the methodology in the form of a taxonomy different types of errors and potential errors detected in SNOMED-CT.

Russell’s rejection in 1898 of the doctrine of internal relations — the view that all relations are grounded in the intrinsic properties of the terms related — was a decisive part of his break with Hegelianism and opened the way for his turn to analytic philosophy. Before rejecting it, Russell had given the doctrine little thought, though it played an essential role in the most intractable of the problems facing his attempt to construct a Hegelian dialectic of the sciences. I (...) argue that it was Russell’s early reading of Leibniz, in preparation for his lectures on Leibniz given at Cambridge in 1899, that most probably alerted him to the role the doctrine was playing in his own philosophy. Leibniz defended a similar doctrine and extricated it from difficulties like those faced by Russell by means of devices that were not open to Russell. Russell would have come across these views of Leibniz in writings by Leibniz that he read in the summer of 1898, just before he rejected the doctrine of internal relations. (shrink)

If SNOMED CT is to serve as a biomedical reference terminology, then steps must be taken to ensure comparability of information formulated using successive versions. New releases are therefore shipped with a history mechanism. We assessed the adequacy of this mechanism for its treatment of the distinction between changes occurring on the side of entities in reality and changes in our understanding thereof. We found that these two types are only partially distinguished and that a more detailed study is required (...) to propose clear recommendations for enhancement along at least the following lines: (1) explicit representation of the provenance of a class; (2) separation of the time-period during which a component is stated valid in SNOMED CT from the period it is (or has been) valid in reality, and (3) redesign of the historical relationships table to give users better assistance for recovery in case of introduced mistakes. (shrink)

Electronic Health Records (EHRs) are organized around two kinds of statements: those reporting observations made, and those reporting acts performed. In neither case does the record involve any direct reference to what such statements are actually about. They record not: what is happening on the side of the patient, but rather: what is said about what is happening. While the need for a unique patient identifier is generally recognized, we argue that we should now move to an EHR regime in (...) which all clinically salient particulars – from the concrete disorder on the side of the patient and the body parts in which it occurs to the concrete treatments given – should be uniquely identified. This will allow us to achieve interoperability among different systems of records at the level where it really matters: in regard to what is happening in the real world. It will also allow us to keep track of particular disorders and of the effects of particular treatments in a precise and unambiguous way. We discuss the ontological and epistemological aspects of our claim and describe a scenario for implementation within EHR systems. (shrink)

The goal of the OBO (Open Biomedical Ontologies) Foundry initiative is to create and maintain an evolving collection of non-overlapping interoperable ontologies that will offer unambiguous representations of the types of entities in biological and biomedical reality. These ontologies are designed to serve non-redundant annotation of data and scientific text. To achieve these ends, the Foundry imposes strict requirements upon the ontologies eligible for inclusion. While these requirements are not met by most existing biomedical terminologies, the latter may nonetheless support (...) the Foundry’s goal of consistent and non-redundant annotation if appropriate mappings of data annotated with their aid can be achieved. To construct such mappings in reliable fashion, however, it is necessary to analyze terminological resources from an ontologically realistic perspective in such a way as to identify the exact import of the ‘concepts’ and associated terms which they contain. We propose a framework for such analysis that is designed to maximize the degree to which legacy terminologies and the data coded with their aid can be successfully used for information-driven clinical and translational research. (shrink)

The paradigm of referent tracking is based on a realist presupposition which rejects so-called negative entities (congenital absent nipple, and the like) as spurious. How, then, can a referent tracking-based Electronic Health Record deal with what are standardly called ‘negative findings’? To answer this question we carried out an analysis of some 748 sentences drawn from patient charts and containing some form of negation. Our analysis shows that to deal with these sentences we need to introduce a new ontological relationship (...) between a particular and a universal, which holds when no instance of the universal has a specific qualified ontological relation with the particular. This relation is found to be able to accommodate nearly all occurrences of negative findings in the examined sample, in ways which involve no reference to negative entities. (shrink)

In his critical notice of Russell's Theory of Knowledge, R. E. Tully takes issue with my interpretation of Wittgenstein's criticism of Russell's theory of judgment. Against it he raises two objections and also sketches an alternative interpretation. On Tully's characterization, I believe that Russell was shot out of the tree by a subtle but devastating argument, while Tully believes that he was shaken out of the tree by a much broader but non-lethal attack on his conception of a proposition. The (...) metaphor is not inappropriate. I certainly believe that Wittgenstein's attack was lethal to Russell's theory of judgment and shows extraordinary marksmanship. But I do not want to deny that there was a lot of tree shaking going on at the same time—concerning, in particular, the logical constants and the concept of a proposition, both of which were topics closely related to the theory of judgment. Thus, while I maintain that Russell was shot, I do not subscribe to a single-bullet theory. (shrink)

Referent tracking (RT) is a new paradigm, based on unique identification, for representing and keeping track of particulars. It was first introduced to support the entry and retrieval of data in electronic health records (EHRs). Its purpose is to avoid the ambiguity that arises when statements in an EHR refer to disorders or other entities on the side of the patient exclusively by means of compound descriptions utilizing general terms such as ‘pimple on nose’ or ‘small left breast tumor’. In (...) this paper, we describe the theoretical foundations of this paradigm and show how it is being applied to the solution of analogous problems of ambiguous identification in the fields of digital rights management, corporate memories and decision algorithms. (shrink)

Definitive diagnosis of malaria requires the demonstration through laboratory tests of the presence within the patient of malaria parasites or their components. Since malaria parasites can be present even in the absence of malaria manifestations, and since symptoms of malaria can be manifested even in the absence of malaria parasites, malaria diagnosis raises important issues for the adequate understanding of disease, etiology and diagnosis. One approach to the resolution of these issues adopts a realist view, according to which the needed (...) clarifications will be derived from a careful representation of the entities on the side of the patient which form the ultimate truthmakers for clinical statements. We here address a challenge to this realist approach relating to the diagnosis of malaria, and show how this challenge can be resolved by appeal to Basic Formal Ontology (BFO) and to the Ontology for General Medical Science (OGMS) constructed in its terms. (shrink)

This paper explores the role of early imperial Peripatetics – in particular, Andronicus of Rhodes, Boethus of Sidon, Herminus, and Alexander – in the development of the canonical reading of the Categories influentially maintained by Porphyry. I investigate the common threads of Middle Platonist and Peripatetic views on the value of the Categories, focusing on the utility of the method of division (diairesis) for acquiring knowledge (epistêmê), and argue for a shared Peripatetic-Platonist consensus about the reasons why the Categories should (...) ground the philosophical curriculum. In particular, I suggest that Andronicus of Rhodes and Eudorus might have played a significant role in the development of this consensus. (shrink)

The article tries to qualify the contentious issue of whetherthere is a human right to welfare. Our notion of human rightsis practically without criteria for distinguishing between whenit is used correctly and when incorrectly. The first step inany satisfactory resolution of the issue about welfare rightsis to supply duly determinate criteria. I then consider thechief reasons for doubting that there is a human right towelfare, in the light of what seem to be, all things considered,the best criteria to attach to (...) the notion of a human right. (shrink)

In Woman and Nature: The Roaring Inside Her, Susan Griffin's embedding of language and culture within the natural world implicitly offers a critique of widespread assumptions, shared by many feminists, that language belongs only to the powerful and that it is inherently violent. Griffin's depiction of the process through which women come to speech is illuminated by V. N. Vološinov's work on the multiaccentuality of language and by Trinh Minh-ha's characterizations of oral traditions. Both authors stress the constant (...) re-creation of language by speakers and listeners. (shrink)

For corporate memory and enterprise ontology systems to be maximally useful, they must be freed from certain barriers placed around them by traditional knowledge management paradigms. This means, above all, that they must mirror more faithfully those portions of reality which are salient to the workings of the enterprise, including the changes that occur with the passage of time. The purpose of this chapter is to demonstrate how theories based on philosophical realism can contribute to this objective. We discuss how (...) realism-based ontologies (capturing what is generic) combined with referent tracking (capturing what is specific) can play a key role in building the robust and useful corporate memories of the future. (shrink)