In an adaptive clinical trial , key trial characteristics may be altered during the course of the trial according to predefined rules in response to information that accumulates within the trial itself. In addition to having distinguishing scientific features, adaptive trials also may involve ethical considerations that differ from more traditional randomized trials. Better understanding of clinical trial experts’ views about the ethical aspects of adaptive designs could assist those planning ACTs. Our aim was to elucidate the opinions of clinical (...) trial experts regarding their beliefs about ethical aspects of ACTs. (shrink)

At the forefront of international concerns about global legislation and regulation, a host of noted environmentalists and business ethicists examine ethical issues in consumption from the points of view of environmental sustainability, economic development, and free enterprise.

If a bit of perceptual behavior is a trope, so is any response to a stimulus, and so is the stimulus, and so therefore, more generally, is every effect and its cause. When we say that the sunlight caused the blackening of the film we assert a connection between two tropes; when we say that Sunlight in general causes Blackening in general, we assert a corresponding relation between the corresponding universals. Causation is often said to relate events, and generally speaking (...) any event is a trope: a smile, a sneeze, a scream, an election, a cold snap, a storm, a lightning flash, a conspiracy, perhaps a wave, and so on up to such big and important events that they have proper names, like the Passover and Lulu the H-bomb explosion. We have called a trope a "case" of its universal, while the universal is the "kind" of the trope, so it is no surprise that a medical "case" is a trope--in the sense, at any rate, in which a person is said to have a case of typhoid fever rather than to be a case of it. A high-school boy, uncoached, has assured me, "Of course there's such a thing as Redness--this pencil has a case of it." When a scientist reports a temperature or a velocity or a viscosity he is reporting a trope--not a universal, because it is a once-for-all occurrence, but not a concrete thing either, though doubtless a component of one. He is likely to call it an "aspect" of the thing or, preferably, a "state," and generally speaking a "state" of a thing or a nation is a trope. Recent developments in sub-atomic physics, a none too reliable oracle, suggest that an electron, e.g., just is an existent state, and that the common-sense philosophy of concreta here abdicates altogether in favor of the trope. (shrink)

We review the role of reference within Davidson's T‐theoretic account of language and examine his contention that reference is inscrutable. More generally, we look at the explanatory role of reference in the context of Davidson's philosophy: whether there are explanations that directly appeal to reference, and whether there are explanations that appeal to beliefs about reference.

A compilation of essays that cover the life and work of Masao Abe, one of the greatest Zen Buddhist communicators of the 20th century. Masao Abe has opened up a rich dialogue between Japan and the West. He is considered the leading living Zen figure in the Kyoto School of Buddhist thought and the successor of D.T. Suzuki, his early mentor, as the foremost exponent of Zen Buddhism in the West. In this volume, through stories and recollections, 35 leading intellectual (...) figures explore Abe's encounter with the West, incl'g. his work on interfaith dialogue as a basis for world peace, as well as his comparative philosophical scholarship over the past 30 years. "An extraordinary step ahead in the encounter between Zen and the West.". (shrink)

This article proposes ‘Recursive Consequentialism’: the moral theory which gives agents whatever advice will produce good consequences by being given. It can be thought of as a version of Donald Regan's ‘Cooperative Utilitarianism’ to which two additional elements have been added: allowing people with differing conceptions of ‘good consequences’, e.g., a Utilitarian and a non-Utilitarian, to cooperate with one another, and taking into account the full consequences of accepting, not just complying with, moral guidance. The theory is motivated by (...) a series of game-theoretic examples in which adherence to alternative Consequentialist moral theories produces bad consequences. (shrink)

Argues against G.E. Moore's thesis that "good" is unanalysable. Consulting the dictionary ("more illuminating than many volumes of rational axiology"), Williams concludes that the fundamental meaning of "good" is being in accord with my purposes. That does not rule out a search for some highest good that will unify my purposes.

Donald Davidson notoriously rejected ‘metaphorical meaning’ and denied the existence of linguistic mechanisms by which metaphorical significance is conveyed. He contended that the meanings metaphorical sentences have are just their literal meanings, though metaphorical utterances may brute-causally have important cognitive effects. Contrastingly, John Searle offers a Gricean account of metaphor as an elaborated kind of implicature, and defends metaphorical meaning as speaker-meaning. Each of those positions is subject to very telling objections from the other's point of view. This paper (...) proposes a synthesis that combines the respective virtues of Davidson's and Searle's accounts and avoids all the objections to each. (shrink)

There is an exciting semantic program, defended primarily in the recent works of Donald Davidson and Gilbert Harman, which makes use of both classical truth-conditional semantic method and contemporary transformational syntax, and which is believed to provide illuminating semantical accounts of particular natural languages to which it is applied. I shall call this program, composed of Davidson’s and Harman’s common methodology together with the semantical and metatheoretical claims which it encapsulates, “the D-H Metatheory.”.

The semantic paradoxes arise when the range of the quantifiers in the object language is too generous in certain ways. But it is not really clear how unfair to Urdu or to Hindi it would be to view the range of their quantifiers as insufficient to yield an explicit definition of ‗true-in-Urdu‘ or ‗true-in- Hindi‘. Or, to put the matter in another, if not more serious, way, there may in the nature of the case always be something we grasp in (...) understanding the language of another (the concept of truth) that we cannot communicate to him. In any case, most of the problems of general philosophical interest arise within a fragment of the relevant natural language that may be conceived as containing very little set theory. Of course these comments do not meet the claim that natural languages are universal. But it seems to me this claim, now that we know such universality leads to paradox, is suspect. –―Truth and Meaning‖. (shrink)

Davidson made a strikingly distinctive and valuable contribution to the practice of ontology. It was a species of argument for the existence of things of one kind or another. It combined Quine's doctrine that “To be is to be the value of a bound variable” with Davidson's own apparently anti‐Quinean views on semantics and logical form in natural language. Roughly: Suppose truth‐conditional analysis of certain English sentences assigns them logical forms containing characteristic quantifiers, and the quantifiers' domains include entities of (...) a certain sort. Then, assuming that some of the relevant sentences are true, it follows that there exist entities of that sort. This chapter expounds Davidson's extended defense of that method, and then considers and tries to rebut five potential objections to it. (shrink)

It may seem odd to review a New York social club's yearbook, with its list of members’ addresses and series of committee reports. But such books sometimes contain material of more general interest. The latest one from the Century Association, for example, devotes 250 of its 685 pages to “Century Memorials”—that is, biographical sketches of recently deceased members, written by other members. Among the well-known figures taken up in these eighty-three sketches are the artists Richard Anuszkiewicz and Robert Motherwell; the (...) architects Henry N. Cobb and Charles A. Platt; the newspaper editors Harold Evans and Whitelaw Reid; the historians Henry F. Graff and William McFeely; the translator and literary scholar Donald Keene; the collector of literary and musical manuscripts Frederick Koch; the popular writer on Russian history Robert K. Massie; the clergyman James Parks Morton; the financier Felix G. Rohatyn; the lawyers Whitney North Seymour Jr. and Isaac N. Phelps Stokes; the literary editor Elisabeth Sifton; the university president Michael Sovern; the museum director Evan H. Turner; and the broadcast journalist Sander Vanocur. The sketches are generally well written and often richly evocative: the writers include Louis Begley, Kenneth T. Jackson, D. T. Max, and Honor Moore.The long shelf of Century volumes like this one clearly constitutes a valuable contribution to prosopographical literature. And the Century is not the only institution with such a tradition (other examples are the British Academy and the American Philosophical Society); but their publications are a frequently overlooked source, one not always available in research libraries. Unfortunately, it is also a source that seems to be diminishing: the American Antiquarian Society and the John Simon Guggenheim Memorial Foundation are examples of organizations, each with a history of providing biographical information, that are no longer doing so. Of course, the great previous runs of the former's Proceedings and the latter's Reports remain (one hopes) on the shelves for those who know to look for them. A step in the opposite direction has recently been taken by the Grolier Club, which has not had such a tradition (except for two biographical volumes in 1959 and 2000): its Gazette now includes a section of memorials in each issue. This is a welcome move, but one has to regret that so little scholarly use is made of this whole body of biographical detail and reminiscence. (shrink)

A biological explanation for the dependence of genome-wide mutation-rate variation on local base context is now becoming clearer. The proportions of G + C relative to A + T—expressed as GC%—is a species-specific DNA character. The frequencies of these single bases correlate with frequencies of corresponding oligonucleotides that are more-sensitive indicators of species specificity. Thus, when k = 3 there are 64 possible trinucleotide sequences and a GC%-rich species has a high frequency of GC-rich 3-mers. Closely related species have similar (...) k-mer patterns. For distantly related species, even if happening to have the same GC% values, k-mer patterns are widely discordant. Conventionally, a base substitution mutation is viewed as a chemical 1-mer phenomenon. However, the selective difference by which the corresponding mutation is scored usually relates to context. Thus, an A to U codon mutation in sickle cell anemia, rather than attracting an anticodon in a structural loop of glutamate tRNA, pairs with the more complementary anticodon loop of valine tRNA. Likewise, a recent statistical analysis of genome-wide mutation-rate variation supports the view that a failure of discordant DNA loops to pair at meiosis can initiate and/or sustain the speciation process. Such disharmony among base patterns may have unknowingly been hinted at by geneticist William Bateson who invoked a music metaphor when considering speciation mechanisms. (shrink)

Chapter three shows that MacIntyre's misunderstanding of what psychoanalysis means by the unconscious leads him to treat it as unobservable. In any intelligible sense, the unconscious is not absolutely unobservable, or else being unobservable is no stigma unique to it; conscious ideas, wishes, e.g., will have to be classed as unobservable, too. MacIntyre's central error is his failing to see that free-association makes the unconscious observable. The chapter concludes with an examination of the concepts of absolute unobservability and observability in (...) contemporary philosophy of science. The idea of an entity or property whose essence it is to be unobservable --that is, of an entity or property that is unobservable in all possible worlds--is absurd. ;Chapter two exposes the fallaciousness of James's claim that on a priori grounds alone the very idea of unconscious mental activity is incoherent. Then, against his claim that brain-processes and/or conscious mental processes that are "quickly gone, unattended to, or forgotten" can explain any phenomenon supposed to need unconsicous mental processes to explain, I argue that the case of resistance to one's own ideas and wishes cannot be accounted for in any of the ten ways James considers; indeed, there are reasons why no explanation of the sorts he considers can be adequate to explain resistance. ;This difference in logical form is missed by Wittgenstein when he confuses the logcial form of an interpretation with the logical form of that of which it is an interpretation--e.g., a dream or symptom. Freud does treat dreams, symptoms, as having meaning, saying things; the condensations and displacements in dreams say "This is really this," "This is all a repetition of that." For Freud, the form of the interpretation is "This dream says 'This is really this,'" Wittgenstein is able to make it plausible to treat interpretations as mythological only by assuming that interpretations are of the same logical form as the dreams they are about. ;They fail, I argue, because each distorts or fails to take account of the same crucial features of unconscious mental processes as psychoanalysis attributes them; these critics assume that the phenomenon the unconscious is needed in order to explain is that of inadvertent, unwitting behavior. Even Freud sometimes slipped in this way--the argument from post-hypnotic suggestion examined in Chapter two also assumes that unwitting behavior of a certain sort requires unconscious mental activity for its explanation. In reality, it is resistance and transference phenomena which justify introduction of the concept of the unconscious. Besides, Freud's method of attributing unconscious mental activity is based on free-association, a wholly novel technique, which produces statements--interpretations--of a different logical form from non-psychoanalytic formulations attributing unconscious mental activity in order to explain inadvertent action. ;Chapter one deals with Wittgenstein's view of psychoanalytic interpretations as a mythology imposted upon subjects. Chapter two examines one of Freud's main proofs for the existence of unconsious mental activity, the argument from post-hypnotic suggestion, and then considers William James's arguments to show that the concept of unconscious mental activity is incoherent, i.e., self-contradictory, and that the concept is unnecessary in that any phenomenon supposed to require the concept to be explained can be explained instead by reference merely to conscious mental processes and/or brain-processes. Chapter three deals with A. MacIntyre's argument to show that the unconscious is unobservable in a way that distinguishes it from legitimate unobservables in science; unlike them, the unconsicous is dispensable in principle. These three criticisms exhaust the main attacks that have been made on the scientific status of the unconscious. (shrink)

Part I: The Life of Cognitive Science:. William Bechtel, Adele Abrahamsen, and George Graham. Part II: Areas of Study in Cognitive Science:. 1. Analogy: Dedre Gentner. 2. Animal Cognition: Herbert L. Roitblat. 3. Attention: A.H.C. Van Der Heijden. 4. Brain Mapping: Jennifer Mundale. 5. Cognitive Anthropology: Charles W. Nuckolls. 6. Cognitive and Linguistic Development: Adele Abrahamsen. 7. Conceptual Change: Nancy J. Nersessian. 8. Conceptual Organization: Douglas Medin and Sandra R. Waxman. 9. Consciousness: Owen Flanagan. 10. Decision Making: J. Frank Yates (...) and Paul A. Estin. 11. Emotions: Paul E. Griffiths. 12. Imagery and Spatial Representation: Rita E. Anderson. 13. Language Evolution and Neuromechanisms: Terrence W. Deacon. 14. Language Processing: Kathryn Bock and Susan M. Garnsey. 15. Linguistics Theory: D. Terence Langendoen. 16. Machine Learning: Paul Thagard. 17. Memory: Henry L. Roediger III and Lyn M. Goff. 18. Perception: Cees Van Leeuwen. 19. Perception: Color: Austen Clark. 20. Problem Solving: Kevin Dunbar. 21. Reasoning: Lance J. Rips. 22. Social Cognition: Alan J. Lambert and Alison L. Chasteen. 23. Unconscious Intelligence: Rhianon Allen and Arthur S. Reber. 24. Understanding Texts: Art Graesser and Pam Tipping. 25. Word Meaning: Barbara C. Malt. Part III: Methodologies of Cognitive Science:. 26. Artificial Intelligence: Ron Sun. 27. Behavioral Experimentation: Alexander Pollatsek and Keith Rayner. 28. Cognitive Ethology: Marc Bekoff. 29. Deficits and Pathologies: Christopher D. Frith. 30. Ethnomethodology: Barry Saferstein. 31. Functional Analysis: Brian Macwhinney. 32. Neuroimaging: Randy L. Buckner and Steven E. Petersen. 33. Protocal Analysis: K. Anders Ericsson. 34. Single Neuron Electrophysiology: B. E. Stein, M.T. Wallace, and T.R. Stanford. 35. Structural Analysis: Robert Frank. Part IV: Stances in Cognitive Science:. 36. Case-based Reasoning: David B. Leake. 37. Cognitive Linguistics: Michael Tomasello. 38. Connectionism, Artificial Life, and Dynamical Systems: Jeffrey L. Elman. 39. Embodied, Situated, and Distributed Cognition: Andy Clark. 40. Mediated Action: James V. Wertsch. 41. Neurobiological Modeling: P. Read Montague and Peter Dayan. 42. Production Systems: Christian D. Schunn and David Klahr. Part V: Controversies in Cognitive Science:. 43. The Binding Problem: Valerie Gray Hardcastle. 44. Heuristics and Satisficing: Robert C. Richardson. 45. Innate Knowledge: Barbara Landau. 46. Innateness and Emergentism: Elizabeth Bates, Jeffrey L. Elman, Mark H. Johnson, Annette Karmiloff-Smith, Domenico Parisi, and Kim Plunkett. 47. Intentionality: Gilbert Harman. 48. Levels of Explanation and Cognition Architectures: Robert N. McCauley. 49. Modularity: Irene Appelbaum. 50. Representation and Computation: Robert S. Stufflebeam. 51. Representations: Dorrit Billman. 52. Rules: Terence Horgan and John Tienson. 53. Stage Theories Refuted: Donald G. Mackay. Part VI: Cognitive Science in the Real World:. 54. Education: John T. Bruer. 55. Ethics: Mark L. Johnson. 56. Everyday Life Environments: Alex Kirlik. 57. Institutions and Economics: Douglass C. North. 58. Legal Reasoning: Edwina L. Rissland. 59. Mental Retardation: Norman W. Bray, Kevin D. Reilly, Lisa F. Huffman, Lisa A. Grupe, Mark F. Villa, Kathryn L. Fletcher, and Vivek Anumolu. 60. Science: William F. Brewer and Punyashloke Mishra. Selective Biographies of Major Contributors to Cognitive Science: William Bechtel and Tadeusz Zawidzki. (shrink)

Book reviewed in this article: In Search of History: Historiography in the Ancient World and the Origins of Biblical History. By John Van Seters. The Hidden God: The Hiding of the Face of God in the Old Testament. By Samuel E. Balentine. Theodicy in the Old Testament. Edited by James L. Crenshaw. Ce Dieu censé aimer la Souffrance. By François Varone. Evil and Evolution, A Theodicy. By Richard W. Kropf. ‘Poet and Peasant’ and ‘Through Peasant Eyes’: A Literary‐Cultural Approach to (...) the Parable in Luke. By Kenneth Bailey. The Biblical Foundations for Mission. By Donald Senior and Carroll Stuhlmueller. New Testament Foundations of Ministry. By Colin Kruse. Church, Ministry and Unity. By James E. Griffiss. Theology of Ministry. By Thomas Franklin O'Meara. Yesterday and Today: A Study of Continuities in Christology. By Colin E. Gunton. I believe in the Holy Spirit. By Yves Congar. Between Jesus and Paul. By Martin Hengel. From Nicaea to Chalcedon: A Guide to the Literature and its Background. By Frances Young. Alan of Lille: The Frontiers of Theology in the Later Twelfth Century. By G.R. Evans. Mystic and Pilgrim: The Book and the World of Margery Kempe. By Clarissa W. Atkinson. Church, Politics and Society: Scotland 1408–1929. Edited by N. Macdougall. Renaissance and Reform: The Italian Contribution. Collected Essays, Volume II. By Frances A. Yates. Seven‐Headed Luther: Essays in Commemoration of a Quincentury, 1483–1983. Edited by Peter Newman Brooks. Ökumenische Erschliessung Martin Luthers. Edited by Peter Manns and Harding Meyer. Luther's Ecumenical Significance, An Interconfessional Consultation. Edited by Peter Manns and Harding Meyer, in collaboration with Carter Lindberg and Harry McSorley. States of Mind: A Study of Anglo‐Irish Conflict 1780 to 1980. By Oliver MacDonagh. The Parish Clergy in Nineteenth‐Century Russia: Crisis, Reform, Counter Reform. By Gregory L. Freeze. Pusey Rediscovered. Edited by Perry Butler. Between Two Worlds: George Tyrrell's Relationship to the Thought of Matthew Arnold. By Nicholas Sagovsky. The Concept of Glaubenslehre. By Walter E. Wyman, Jr. The Existence and Nature of God. Edited by Alfred J. Freddoso. Faith and Reason. By Anthony Kenny. Logic and The Nature of God. By Stephen T. Davis. Personal Responsibility and Christian Morality. By Josef Fuchs. Morality and Conflict. By Stuart Hampshire. Realism and Imagination in Ethics. By Sabina Lovibond. Intentionality. By John R. Searle. Philosophical Papers, I: Practical Reason. By G.H. von Wright. Philosophical Papers, II: Philosophical Logic. By G.H. von Wright. A Model of Making: Literary Criticism and its Theology. By Ruth Etchells. The Return of the Goddess: Femininity, Aggression and the Modern Grail Quest. By Edward Whitmont. The Power of the Poor in History. By Gustavo Gutierrez, translated by Robert R. Barr. The God of the Xhosa. By Janet Hodgson. Our Hymn Tunes: Their Choice and Performance. By Donald Webster. The Almighty Wall: The Architecture of Henry Vaughan. By William Morgan. An Introduction to Plato's Laws. By R.E. Stalley. Plato's Late Ontology: A Riddle Resolved. By Kenneth M. Sayre. Plato's ‘Parmenides’: Translation and Analysis. By R.E. Allen. Politics in the Ancient World. By M.I. Finley. (shrink)

It is not uncommon to be frustrated by the outcome of an election or a decision in voting, law, economics, engineering, and other fields. Does this 'bad' result reflect poor data or poorly informed voters? Or does the disturbing conclusion reflect the choice of the decision/election procedure? Nobel Laureate Kenneth Arrow's famed theorem has been interpreted to mean 'no decision procedure is without flaws'. Similarly, Nobel Laureate Amartya Sen dashes hope for individual liberties by showing their incompatibility with societal needs. (...) This highly accessible book offers a new, different interpretation and resolution of Arrow's and Sen's theorems. Using simple mathematics, it shows that these negative conclusions arise because, in each case, some of their assumptions negate other crucial assumptions. Once this is understood, not only do the conclusions become expected, but a wide class of other phenomena can also be anticipated. (shrink)

Some stalwarts are included in any and every collection of readings for students on political and social thought. Among these reliable standbys are Plato, Aristotle, Aquinas, Machiavelli, Hobbes, Locke, Rousseau, Bentham, Mill, Hegel, Marx, Lenin, and Mao Tse-tung. They are all here, marshaled and arrayed in judicious selections, well introduced. But something new has been added in this anthology. You will find in it selections from William F. Buckley, Jr., and Eldridge Cleaver, from Michael Harrington and Frantz Fanon, from Herbert (...) Marcuse and Martin Luther King, Jr., from H. L. A. Hart and Gregory Vlastos, and from others who were or are alive in the latter half of our century. The quality of the material presented is excellent. The final selection, for example, is a first-rate analysis of the notion of a "just war" by Donald A. Wells. The editors, in their general introduction, discuss such questions as what the foundation of political obligation is, how social and political institutions are or may be evaluated, how the ideals of a society are systematized, and what the nature and justification of social change are. A bibliography, a topical syllabus, and an index are usefully provided. This book of readings can confidently be recommended for use as the basic text of a historical or analytical course in political and social philosophy.—W. G. (shrink)

Grafts of embryonic neural tissue into the brains of adult patients are currently being used to treat Parkinson's disease and are under serious consideration as therapy for a variety of other degenerative and traumatic disorders. This target article evaluates the use of transplants to promote recovery from brain injury and highlights the kinds of questions and problems that must be addressed before this form of therapy is routinely applied. It has been argued that neural transplantation can promote functional recovery through (...) the replacement of damaged nerve cells, the reestablishment of specific nerve pathways lost as a result of injury, the release of specific neurotransmitters, or the production of factors that promote neuronal growth. The latter two mechanisms, which need not rely on anatomical connections to the host brain, are open to examination for nonsurgical, less intrusive therapeutic use. Certain subjective judgments used to select patients who will receive grafts and in assessment of the outcome of graft therapy make it difficult to evaluate the procedure. In addition, little long-term assessment of transplant efficacy and effect has been done in nonhuman primates. Carefully controlled human studies, with multiple testing paradigms, are also needed to establish the efficacy of transplant therapy. (shrink)

This chapter defends the account of metaphysical indeterminacy of Barnes and Williams against Eklund's objections.

Explores the thought of Henri Bergson, highlighting his compelling theories on the nature of consciousness and its relationship to the physical world.