The explosion of multiomics data poses new challenges to existing data mining methods. Joint analysis of multiomics data can make the best of the complementary information that is provided by different types of data. Therefore, they can more accurately explore the biological mechanism of diseases. In this article, two forms of joint nonnegative matrix factorization based on the sparse and graph Laplacian regularization method are proposed. In the method, the graph regularization constraint can preserve the local geometric structure of (...) data. L 2,1 -norm regularization can enhance the sparsity among the rows and remove redundant features in the data. First, SG-jNMF1 projects multiomics data into a common subspace and applies the multiomics fusion characteristic matrix to mine the important information closely related to diseases. Second, multiomics data of the same disease are mapped into the common sample space by SG-jNMF2, and the cluster structures are detected clearly. Experimental results show that SG-jNMF can achieve significant improvement in sample clustering compared with existing joint analysis frameworks. SG-jNMF also effectively integrates multiomics data to identify co-differentially expressed genes. SG-jNMF provides an efficient integrative analysis method for mining the biological information hidden in heterogeneous multiomics data. (shrink)

In his essay “Goddesses of the Twenty‐first Century,” R. Buckminster Fuller's use of woman and goddess as metaphor suggests a fruitful source of images illuminating synergetic principles. Using five images, clustered as odyvessel‐matrix, the article suggests an epistemology and a heuristic for connecting the personal‐physical and the universal‐metaphysical. These images are (1) the Egyptian goddess Nut, (2) the Greek earth goddesses, (3) Neolithic Maltese goddess temples, (4) the double spiral, and (5) the Apollo Mission's Earth photographs. These images are (...) intended as transformational synergetic/ecofeminist figures to replace images of deprivation, alienation, and destruction with images of abundance, intimacy, and co‐creation. (shrink)

We propose a rational method for addressing an important question—who deserves to be an author of a scientific article? We review various contentious issues associated with this question and recommend that the scientific community should view authorship in terms of contributions and responsibilities, rather than credits. We propose a new paradigm that conceptually divides a scientific article into four basic elements: ideas, work, writing, and stewardship. We employ these four fundamental elements to modify the well-known International Committee of Medical Journal (...) Editors (ICMJE) authorship guidelines. The modified ICMJE guidelines are then used as the basis to develop an approach to quantify individual contributions and responsibilities in multi-author articles. The outcome of the approach is an authorship matrix, which can be used to answer several nagging questions related to authorship. (shrink)

Purpose. The article aims to comprehend the concept that has a serious anthropological meaning, – a "co-existential educational community" – which points at the real subject and object in the development of the educational reality, as well as to explicate its importance towards understanding the real way of addressing actually to the culture and its acquisition in the pedagogical process. Theoretical basis. To achieve this purpose, the method of categorical-reflexive analysis of texts and problems of real educational realities is used; (...) this allows to involve of such philosophical concepts as "sobornost", "all-unity", "culture" and distinguish their anthropological meaning. Under this approach, philosophical categories are able to appear as internal dimensions of the essence in the educational process, rather than a certain matrix, for which one or another theoretical or practical construction is adjusted. Originality. The originality of the article lies in the actualization of philosophical content in "sobornost" and "all-unity" concepts for philosophical-educational discourse and in solving the question on the real way of entering culture in the context of pedagogical communication. Conclusions. Addressing the idea of a co-existential educational community is able to oppose the widespread superficial notions of the so-called "educational environment" in the pedagogical and psychological literature and orient pedagogical theory and pedagogical practices on the real way of entering the individual into truly human forms of life. It is argued that the co-existential educational community can and should unfold not only "horizontally", but also "vertically", consciously integrating the high culture in itself as a culture of high. The authors emphasized the role of imagination in this process. Education can and should build co-existence with the culture of participants in pedagogical communication. It is with this approach that the education sector can emerge from the systemic crisis and actively oppose those trends in modern social life that increase alienation and depopulation. (shrink)

Résumé Et toi, quel est ton genre? Les Betty, intellectuelles précaires, partageant un désir militant, critiques tant vis-à-vis des groupes féministes historiques, que des pratiques politiques au sein du mouvement des mouvements, nous racontent leur création d’un espace, le "sexishock" au cœur même d’un centre social à Bologne.

"Contra la postmodernidad" entabla una polémica con las principales contribuciones políticas, sociológicas y filosóficas de los últimos tiempos. Comparecen ante el tribunal pensadores como Zygmunt Bauman, Anthony Giddens, Agnes Héller, Toni Negri, Simon Critchley, Gianni Vattimo, Eloy Fernández Porta y Jean-François Lyotard, entre otros. Se discuten las falacias de la economía neoclásica, el fetichismo de la alteridad radical y la retórica de la diferencia. A esto se añade una ardua polémica con aquella forma de filosofía obsesionada con el suicidio de (...) la razón, la muerte de la metafísica y la superación de la Modernidad. También se debate sobre la crisis del proyecto europeo y sobre movimientos sociales recientes como el 15-M o la primavera árabe. La tesis principal del libro afirma que la postmodernidad hace tiempo que llegó a su fin, sus categorías no son aplicables a un tiempo como el nuestro, marcado por una grave crisis económica, ecológica y social. Asistimos al regreso de la lucha de clases, la geopolítica, las estrategias neocoloniales, el populismo y el fundamentalismo étnico, cultural y religioso. En este contexto de grandes transformaciones, la apuesta normativa del postmodernismo resulta intelectualmente muy pobre y políticamente inútil. El afán por las cuestiones culturales e identitarias lleva a que muchos de sus autores olviden deliberadamente el análisis económico del sistema. Por este motivo, el postmodernismo resulta ser, en la mayor parte de los casos, una réplica exacta de la ideología neoliberal. (shrink)

Este livro pretende ser um convite à leitura das obras de Álvaro Vieira Pinto. Chama-se 'Esperança e democracia' porque no núcleo do pensar desse, que foi o mais consistente filósofo do nacionalismo brasileiro, estão a esperança - o ânimo de quem não teme o destino e quer projetar no mundo as marcas da sua vontade - e a democracia, o regime político dos homens comuns.

Esta contribución, enmarcada en las V y VI convocatorias de proyectos de innovación docente de la Universidad de Cantabria (España), demuestra los resultados obtenidos tras la incorporación de metodologías docentes de gamificación y de creación de video-píldoras informativas en el contexto de aprendizaje de Geo-tecnologías. El alumnado participante mostró un grado de satisfacción muy elevado con el proyecto de innovación, alcanzando una media de 4.45 sobre 5 y las competencias de la asignatura se lograron satisfactoriamente. La experiencia es exportable a (...) otros contextos docentes sin necesidades de financiación específicas. (shrink)

This comprehensive sourcebook of Philo of Alexandria presents topics and themes drawn from commonly studied Philonic texts in seven chapters: theology, cosmology, anthropology, ethics, biblical characters, Jewish Law, and Jewish worship and observances.

This book examines Philo's understanding of the acquisition of virtues and the avoidance of vices using the Greek concept of piety as a central virtue in his ethical discourse. Naveros exceptionally shows how Philo construes his understanding of living ethically within both the Hellenistic Jewish and Greek traditions.