El presente artículo recapacita sobre las reformas normativas acontecidas en las últimas décadas respecto al uso racional de los medicamentos, y las medidas operadas en torno a la disminución del gasto farmacéutico. En este contexto, debe destacarse el elevado coste de las terapias biológicas y las dificultades de acceso a las mismas —especialmente en los países en vías de desarrollo—. Los medicamentos biosimilares son poseedores de garantías sanitarias análogas —semejantes o equivalentes— a los medicamentos de referencia, pero no están sometidos (...) a una protección por una patente y facilitan la accesibilidad a los pacientes, así como al reparto equitativo de los recursos terapéuticos. Además, algunos de ellos están incluido en la lista de medicamentos esenciales de la Organización Mundial de la Salud (OMS).Asimismo, se examina el papel de los medicamentos biosimilares como esenciales y la posibilidad de mejorar el acceso equitativo a estos recursos sanitarios a través de la prestación farmacéutica. (shrink)

In order to create a post-neoliberal society we need to change the way we look at the world. This article begins by considering the lesson learned in the case of “Mont Pèlerin,” where ideas that th...

In this work, we focus on the problem of selecting low-level heuristics in a hyperheuristic approach with offline learning, for the solution of instances of different problem domains. The objective is to improve the performance of the offline hyperheuristic approach, identifying equivalence classes in a set of instances of different problems and selecting the best performing heuristics in each of them. A methodology is proposed as the first step of a set of instances of all problems, and the generic characteristics (...) of each instance and the performance of the heuristics in each one of them are considered to define the vectors of characteristics and make a grouping of classes. Metalearning with statistical tests is used to select the heuristics for each class. Finally, we used the Naive Bayes to test the set instances with k-fold cross-validation, and we compared all results statistically with the best-known values. In this research, the methodology was tested by applying it to the problems of capacitated vehicle routing and graph coloring. The experimental results show that the proposed methodology can improve the performance of the offline hyperheuristic approach, correctly identifying the classes of instances and applying the appropriate heuristics in each case. This is based on the statistical comparison of the results obtained with those of the state of the art of each instance. (shrink)

This volume brings together eminent theologians, philosophers and political theorists to discuss such questions as how religious understandings have shaped the moral landscape of contemporary culture; the possible contributions of theology and theologically informed moral argument to contemporary public life; the problem of religious and moral discourse in a pluralistic society; and the proper relationship between religion and culture.

En la ciudad de Medellín se hace uso de herramientas y dispositivos, en el marco de la llamada Gestión Social, para ejecutar importantes obras para el llamado desarrollo urbano, que bien pueden configurar una “Gestión social del despojo”, en el marco de una “Planeación institucional de la miseria y el desarraigo”, generando víctimas ya no del conflicto armado sino del desarrollo. Es necesario problematizar esta suerte de modelo de desarrollo urbano, su gestión e implementación.

In this paper we present a new framework of idealization in biology. We characterize idealizations as a network of counterfactual and hypothetical conditionals that can exhibit different “degrees of contingency”. We use this idea to say that, in departing more or less from the actual world, idealizations can serve numerous epistemic, methodological or heuristic purposes within scientific research. We defend that, in part, this structure explains why idealizations, despite being deformations of reality, are so successful in scientific practice. For illustrative (...) purposes, we provide an example from population genetics, the Wright-Fisher Model. (shrink)

Recensión de J. M. Blanco White, Bosquejo del comercio de esclavos, edición de M. Moreno Alonso, Alfar, Sevilla, 1999.

El presente artículo, refiere una investigación de carácter cualitativo, desarrollada con el propósito de interpretar los significados construidos por los docentes sobre la evaluación en sus prácticas, se contextualiza en la escuela primaria del Núcleo Escolar Rural N°323 en el estado Falcón, Venezuela, llevada a cabo en el año escolar 2016-2017. Asumido este quehacer como multireferencial, cíclico, emergente, co-construido y cambiante, fue abordado con una metódica orientada por la fenomenología social. Para la sistematización de la información se realizaron intercambios y (...) entrevistas en profundidad, mientras que los registros fueron realizados haciendo uso del diario del investigador y equipos tecnológicos como recursos. Los datos fueron analizados siguiendo los procesos de categorización y triangulación de fuentes, con la finalidad de ampliar el fenómeno estudiado para su comprensión. En el contraste, integración e interpretación de los significados se consideraron tres categorías medulares alusivas a la evaluación como proceso complejo, los nudos críticos en las prácticas evaluativas y la evaluación como componente curricular. Los hallazgos develados dan cuenta de los significados construidos por los docentes sobre la evaluación, quienes la plantean como un proceso auténtico, con el propósito de facilitar la mejora del proceso de aprendizaje. (shrink)

In this paper we present a new framework of idealization in biology. We characterize idealizations as a network of counterfactual and hypothetical conditionals that can exhibit different “degrees of contingency”. We use this idea to say that, in departing more or less from the actual world, idealizations can serve numerous epistemic, methodological or heuristic purposes within scientific research. We defend that, in part, this structure explains why idealizations, despite being deformations of reality, are so successful in scientific practice. For illustrative (...) purposes, we provide an example from population genetics, the Wright-Fisher Model. (shrink)

El objetivo de este artículo consiste en abordar algunos argumentos de la filosofía de J. Rancière relacionados con la necesidad de repensar el comunismo. La hipótesis de trabajo insiste en señalar que Rancière no defiende ningún proyecto comunista. Esto al menos por tres razones: no hay igualdad de las inteligencias, el comunista funge como profesor explicador en aras de concientizar a los embrutecidos, el comunismo pertenece a una temporalidad histórica teleológica, lo que a su vez supone un aplazamiento de la (...) emancipación. Finalmente, cerramos este diálogo con las posibilidades presentes de esta otra forma de concebir la igualdad y la emancipación. (shrink)

In this paper we present a new framework of idealization in biology. We characterize idealizations as a network of counterfactual and hypothetical conditionals that can exhibit different “degrees of contingency”. We use this idea to say that, in departing more or less from the actual world, idealizations can serve numerous epistemic, methodological or heuristic purposes within scientific research. We defend that, in part, this structure explains why idealizations, despite being deformations of reality, are so successful in scientific practice. For illustrative (...) purposes, we provide an example from population genetics, the Wright-Fisher Model. (shrink)

The scientific literature has shown Mondragon Corporation, with 65 years of history, as a clear example that cooperativism can be highly competitive in the capitalist market while being highly egalitarian and democratic. This cooperative group has focused on its corporate values of cooperation, participation, social responsibility, and innovation. Previous scientific research reports its enormous transformative and emancipatory potential. However, studies on the effects of various types of worker participation on competitiveness and workers’ psychological wellbeing in this cooperative group exist to (...) a lesser extent. Specifically, one aspect that needs further empirical research and that represents a competitive advantage for Mondragon is the degree of commitment and emotional attachment that can be observed in the people who work there. For this reason, this article aims to identify key elements of the democratic participation of workers in these cooperatives that relate to the development of organizational commitment. Based on a communicative and qualitative approach, data collection included 29 interviews to different profiles of workers from eight different cooperatives of the Corporation. Through this research methodology, the participants interpret their reality through egalitarian and intersubjective dialogue because their voices are considered essential to measure the social impact. This study found three different ways in which the democratic participation of worker-members in management and ownership contributes to developing affective organizational commitment among those working in Mondragon cooperatives, generating positive psychological and economic outcomes for both workers and cooperatives. (shrink)

In the international context of a progress toward more inclusive educational systems and practices, the role of Special Education teachers is being transformed. From an inclusive perspective, these professionals increasingly support students and their teachers in the mainstream classroom, avoiding segregation. However, Special Education teachers often struggle to reach and support all students with special needs and their teachers to provide quality inclusive education. For this reason, more research is still needed on in-service training strategies for the inclusion of students (...) with special needs that effectively translate into evidence-based school practices that improve the education of all students. This article analyses the impact of two evidence-based dialogic training programs of Special Education teachers working in mainstream schools carried out in Mexico during the 2018–2019 school year. Through in-depth interviews with participants, it was identified how, after the training, teachers increasingly grounded their actions on scientific evidence and promoted interactive learning environments that improved the educational inclusion of their students with special needs. This training also became the venue to make evidence-based educational actions available to other students without special needs, improving the quality of education provided to all students. (shrink)

Surgical patient safety remains a concern worldwide as, despite World Health Organization recommendations and implementation of its Surgical Safety Checklist, adverse events continue to occur. The aim of this qualitative study was to explore the views and experiences of perioperative nurses regarding the factors that impact surgical patient safety. Data were collected through five focus groups involving a total of 50 perioperative nurses recruited from four public hospitals in Spain. Content analysis of the focus groups yielded four main themes: personal (...) qualities of the perioperative nurse, the surgical environment, safety culture, and perioperative nursing care plans. One of the main findings concerned barriers to the exercise of leadership by nurses, especially regarding completion of the Surgical Safety Checklist. Some of the key factors that impacted the ability of perioperative nurses to fulfil their duties and ensure patient safety were the stress associated with working in the operating room, time pressures, and ineffective communication in the multidisciplinary team. Targeting these aspects through training initiatives could contribute to the professional development of perioperative nurses and reduce the incidence of adverse events by enhancing the surgical safety culture. (shrink)

In this paper we present a new framework of idealization in biology. We characterize idealizations as a network of counterfactual and hypothetical conditionals that can exhibit different "degrees of contingency". We use this idea to say that, in departing more or less from the actual world, idealizations can serve numerous epistemic, methodological or heuristic purposes within scientific research. We defend that, in part, this structure explains why idealizations, despite being deformations of reality, are so successful in scientific practice. For illustrative (...) purposes, we provide an example from population genetics, the Wright-Fisher Model. (shrink)

Las acciones que articulan simbióticamente élites empresariales y políticas, mafias, grupos militares legales e ilegales, se posibilitan bajo la búsqueda de dos fines: uno, reordenar el territorio de manera violenta hiper-acumulando tierras, con el fin de salvaguardar sus intereses económicos e inversiones; dos, hiper-acumular poder político con el fin de sostener sus privilegios, usando dicho poder para la reconfiguración del diseño institucional y la planeación de los territorios imponiendo sus condiciones. Este fenómeno que marca la historia de Colombia es lo (...) que ampliamente podríamos comprender como Criminalidad Corporativa Instaurada. Es el caso y modelo impuesto en el Urabá el cual se fue extendiendo al resto del país. (shrink)

In this paper we present a new framework of idealization in biology. We characterize idealizations as a network of counterfactual conditionals that can exhibit different degrees of contingency. We use the idea of possible worlds to say that, in departing more or less from the actual world, idealizations can serve numerous epistemic, methodological or heuristic purposes within scientific research. We defend that, in part, it is this structure what helps explain why idealizations, despite being deformations of reality, are so successful (...) in scientific practice. (shrink)

En este artículo se afirma que la idea de ‘virtual’ o de ‘virtualidad’ pertenece a una perspectiva teórica que pretende explicar los componentes del fenómeno de la sociedad tecnológica de hoy en día. En primer lugar, la perspectiva digital es explicada en su estructura ontológica básica: códigos binarios que organizan un set de elementos físicos o un hardware de acuerdo con reglas lógicas. Por ende, la idea de sociedad en red, comunicación virtual y seres humanos digitales son conceptos que no (...) aprehenden realmente el problema de la tecnología digital en nuestra sociedad. Una perspectiva digital asume la necesidad de entender la tecnología digital en su funcionamiento físico, lo que permite una representación completa del problema y permite el análisis crítico subsecuente de la perspectiva virtual. En segundo lugar, la perspectiva virtual es analizada desde la perspectiva digital hasta en sus principales suposiciones metafísicas: la simulación, como un ideal moral presupuesto, y la funcionalidad, como una idea instrumental presupuesta. Finalmente, la conclusión explica las posibilidades dadas por la perspectiva digital en aras de asumir nuevos retos en el universo digital, en contraste con una perspectiva virtual que podría pre-limitar dichas posibilidades para que necesidades previas sean satisfechas. Por ende, este artículo, antes que mostrar un argumento bien definido, exhorta a la reorientación de nuestras nociones acerca de lo virtual y de lo digital. (shrink)

We examine ethical considerations in access to facial transplantation (FT), with implications for promoting health equity. As a form of vascularised composite allotransplantation, FT is still considered innovative with a relatively low volume of procedures performed to date by a small number of active FT programmes worldwide. However, as numbers continue to increase and institutions look to establish new FT programmes, we anticipate that attention will shift from feasibility towards ensuring the benefits of FT are equitably available to those in (...) need. This manuscript assesses barriers to care and their ethical implications across a number of considerations, with the intent of mapping various factors relating to health equity and fair access to FT. Evidence is drawn from an evolving clinical experience as well as published scholarship addressing several dimensions of access to FT. We also explore novel concerns that have yet to be mentioned in the literature. (shrink)

Traditional games are considered agents of enculturation. This article explores the procedure to access the cultural meanings transmitted in a traditional game. The goal is to understand what children aged 6–11 make of the game called ‘the chained bear’ and to compare the meanings retrieved with those of different traditional versions of the game. For such a purpose, through an exploratory cross-sectional study, cartoons depicting people playing the game were exhibited and viewers were asked to interpret them as a drama (...) play, as well as contributing a title, a plot and saying how they would name the characters. The results show that, beyond the individual images that each child created in their mind, most of them coincided in stories about harassment and defense and theft and protection. These plots match those of the ludic tradition, showing that the actions evoke different pictures to each individual, but share common cultural meanings in turn. The study shows a procedure to access the meanings that traditional games transmit and confirms that games contain pieces of culture, which makes them agents of enculturation. (shrink)

Self-control is deemed crucial for reasons-responsive agency and a key contributor to long-term wellbeing. But recent studies suggest that effortfully resisting one’s temptations does not contribute to long-term goal attainment, and can even be harmful. So how does self-control improve our lives? Finding an answer requires revising the role that overcoming temptation plays in self-control. This paper distinguishes two forms of self-control problems: temptation (the presence of a strong wayward motivation) and apathy (the lack of commitment-advancing motivation). This distinction makes (...) it possible to separate negative self-control (aimed at overcoming temptation) from positive self-control (aimed at overcoming lack of motivation). The paper argues that temptation should not play a central role in our conception of self-control, since overcoming temptation is neither necessary nor sufficient for successful self-control. (shrink)

This article proposes a guideline to develop an ontology of software. The first section gives a brief introduction to the importance of such ontology as a possible conceptual grounding for the philosophy of software, philosophy of computing and philosophy of information. The second section presents the background of the scope of this article in terms of both a symbolic and materialistic approach to software. The third section deploys the basic guidelines with the expositions of the two dimensions of software: the (...) serial dimension and the structural dimension. The first dimension consists of three series, while the second in the exposition of the structure of any program. The fourth and last section will deal with a better understanding of what we can call the digital universe. (shrink)

Se ha planteado la inseparable relación entre desarrollo y el crecimiento paramilitar, configurando así, un modelo paraestatal que articula Criminalidad-Empresa-Estado, cuyo objetivo es imponer un modelo de desarrollo hegemónico en los territorios. Es importante profundizar el análisis de dicho modelo a partir de referencias históricas y la inclusión en el análisis del territorio antioqueño como laboratorio de la estrategia paraestatal de desarrollo, en la que se ubicaran génesis y transformaciones de este.

The primary goal of the present research was to determine the order of swimmers on a mixed relay team that would ensure the best performance in the Fédération Internationale de Natation World Championships held in Kazan, Budapest, and Gwangju. The data were obtained from database websites for the 4 × 100 m freestyle and 4 × 100 m medley official results,1 including 660 records from 188 entries of finals and 472 preliminary events. The results showed that the fastest swimmers were (...) located primarily in the first or second positions of the freestyle relay. The most successful gender strategy for the 4 × 100 m freestyle and for the 4 × 100 m medley relays was the order male-male-female-female, although no statistical differences were found for the medley relays. In the 4 × 100 m freestyle, the second and third relay legs had a statistical effect on the total relay time, whereas in the 4 × 100 m medley, all four relay legs had a statistical effect on the final performance, the weight of the four strokes being different in heats with respect to the final round. Also, a later position of the first female swimmer or the consecutive position of two female swimmers in the team order significantly affected the relay performance in specific events. Mixed relay events appeared to present specific strategies in comparison to traditional male- or female-only relay lineups. (shrink)

Psychological flexibility is a key concept of acceptation and commitment therapy. This factor has been linked with psychological wellbeing and associated factors, such as quality of life, in cancer patients. These and other positive results of acceptation and commitment therapy in cancer patients found in previous research could be enhanced by using mhealth tools. A three-arm randomized superiority clinical trial, with a pre-post-follow-up repeated measures intergroup design with a 1:1:1 allocation ratio is proposed. A hundred and twenty cancer patients will (...) be randomly assigned to one of the following interventions: face-to-face ACT + mobile application, face-to-face ACT, and Waitlist control group. The primary expected outcome is to observe significant improvements in psychological flexibility acceptance and action questionnaire- II in the face-to-face ACT + app group, after comparing baseline and post-treatment scores, and the scores will remain stable in the two assessment points, 3 and 6 months after the intervention. Secondary expected outcomes are significant increasing scores in quality of life and post-traumatic-growth, and significant decreasing scores in anxiety and depression, insomnia and fatigue at the same assessment points. Also, it is expected that the scores of this group will be higher than the scores of the face-to-face ACT group and the waitlist control group. This study aims to assess the efficacy of a combined intervention for psychological flexibility and associated symptoms in cancer patients. The results of this protocol may help to consider the use of acceptation and commitment therapy and mhealth applications in cancer settings as a valid therapeutic choice.Clinical Trial Registration[www.ClinicalTrials.gov], identifier [NCT05126823]. (shrink)

RESUMEN Largamente desatendida o malinterpretada, la noción de caos en la filosofía de Nietzsche es una pieza constitutiva de la particular concepción del ser que este autor habría dejado apenas esbozada. El artículo se propone elaborar este concepto en la obra nietzscheana, siguiendo algunas de las metáforas que lo iluminan. Desde allí se busca plantear los rasgos centrales de una ontologia del caos, de sesgo no metafísico, que, al afirmar el carácter acontecimental de la realidad, puede verse como precursora de (...) la ontología hermenéutica contemporánea. ABSTRACT The notion of chaos, which has long been neglected or misinterpreted, is a constitutive element of a peculiar conception of being that the philosopher only had time to outline. The objective of this article is to elaborate on this concept in Nietzschean philosophy, guided by some of the metaphors that shed light on it. This serves as the basis to set forth the main characteristics of a non-metaphysical ontology of chaos that asserts the eventful nature of reality and can thus be seen as a precursor of contemporary hermeneutic ontology. (shrink)