Beauty is truth, truth beauty.If this epigraph only rarely escapes English class, something like it has fascinated philosophers for a long time. Iris Murdoch remembers that "Kant said that beauty was an analogon of good, Plato said it was the nearest clue."2 I want to go further and posit that our means of perception of the aesthetic and the ethical share an organic connection, an understanding of which will help elucidate moral perception, a critical component of moral education.Or moral (...) education as it should be. But what currently counts as such is, directly or almost directly, simple instruction. I ask why this does not work. I ask why Jane Austen said, "We all love to instruct, though we can teach only what is... (shrink)

Nelson Goodman’s theory of symbol systems expounded in his Languages of Art has been frequently criticized on many counts. Yet it exerts a strong influence and is treated as one of the major twentieth-century theories on the subject.While many of Goodman’s controversial theses are criticized, the technical notions he used to formulate them seem to have been treated as neutral tools. One such technical notion is that of the density of symbol systems. This serves to distinguish linguistic symbols from (...) pictorial representations and is a crucial part of Goodman’s explanation of what constitutes aesthetic experience. Thus its significance for Goodman’s theory is fundamental.The aim of this paper is a detailed, logical analysis of this notion. It turns out that Goodman’s definition is highly problematic and cannot be applied to symbol systems in the way Goodman envisaged. To conclude, Goodman’s theory is problematic not just because of its controversial theses but also because of logical problems with the technical notions used at its very core. Hence the controversial claims are not simply contestable, but inaccurately expressed. (shrink)

This note, in rejoinder to a paper by Newton critical of our analysis of certain limitations of quantum scattering theory, seeks to acknowledge and to clarify the disparate interests of the two conflicting articles.

James L. Anderson analyzed the novelty of Einstein's theory of gravity as its lack of "absolute objects." Michael Friedman's related work has been criticized by Roger Jones and Robert Geroch for implausibly admitting as absolute the timelike 4-velocity field of dust in cosmological models in Einstein's theory. Using the Rosen-Sorkin Lagrange multiplier trick, I complete Anna Maidens's argument that the problem is not solved by prohibiting variation of absolute objects in an action principle. Recalling Anderson's proscription of "irrelevant" variables, I (...) generalize that proscription to locally irrelevant variables that do no work in some places in some models. This move vindicates Friedman's intuitions and removes the Jones-Geroch counterexample: some regions of some models of gravity with dust are dust-free and so naturally lack a timelike 4-velocity, so diffeomorphic equivalence to is spoiled. Torretti's example involving constant curvature spaces is shown to have an absolute object on Anderson's analysis, viz., the conformal spatial metric density. The previously neglected threat of an absolute object from an orthonormal tetrad used for coupling spinors to gravity appears resolvable by eliminating irrelevant fields. However, given Anderson's definition, GTR itself has an absolute object : a change of variables to a conformal metric density and a scalar density shows that the latter is absolute. (shrink)

James L. Anderson analyzed the novelty of Einstein's theory of gravity as its lack of "absolute objects." Michael Friedman's related work has been criticized by Roger Jones and Robert Geroch for implausibly admitting as absolute the timelike 4-velocity field of dust in cosmological models in Einstein's theory. Using the Rosen-Sorkin Lagrange multiplier trick, I complete Anna Maidens's argument that the problem is not solved by prohibiting variation of absolute objects in an action principle. Recalling Anderson's proscription of "irrelevant" variables, I (...) generalize that proscription to locally irrelevant variables that do no work in some places in some models. This move vindicates Friedman's intuitions and removes the Jones-Geroch counterexample: some regions of some models of gravity with dust are dust-free and so naturally lack a timelike 4-velocity, so diffeomorphic equivalence to (1,0,0,0) is spoiled. Torretti's example involving constant curvature spaces is shown to have an absolute object on Anderson's analysis, viz., the conformal spatial metric density. The previously neglected threat of an absolute object from an orthonormal tetrad used for coupling spinors to gravity appears resolvable by eliminating irrelevant fields. However, given Anderson's definition, GTR itself has an absolute object (as Robert Geroch has observed recently): a change of variables to a conformal metric density and a scalar density shows that the latter is absolute. (shrink)

James L. Anderson analyzed the novelty of Einstein's theory of gravity as its lack of "absolute objects." Michael Friedman's related work has been criticized by Roger Jones and Robert Geroch for implausibly admitting as absolute the timelike 4-velocity field of dust in cosmological models in Einstein's theory. Using the Rosen-Sorkin Lagrange multiplier trick, I complete Anna Maidens's argument that the problem is not solved by prohibiting variation of absolute objects in an action principle. Recalling Anderson's proscription of "irrelevant" variables, I (...) generalize that proscription to locally irrelevant variables that do no work in some places in some models. This move vindicates Friedman's intuitions and removes the Jones-Geroch counterexample: some regions of some models of gravity with dust are dust-free and so naturally lack a timelike 4-velocity, so diffeomorphic equivalence to is spoiled. Torretti's example involving constant curvature spaces is shown to have an absolute object on Anderson's analysis, viz., the conformal spatial metric density. The previously neglected threat of an absolute object from an orthonormal tetrad used for coupling spinors to gravity appears resolvable by eliminating irrelevant fields. However, given Anderson's definition, GTR itself has an absolute object : a change of variables to a conformal metric density and a scalar density shows that the latter is absolute. (shrink)

Inflationary cosmology won a large following on the basis of the claim that it solves various problems that beset the standard big bang model. We argue that these problems concern not the empirical adequacy of the standard model but rather the nature of the explanations it offers. Furthermore, inflationary cosmology has not been able to deliver on its proposed solutions without offering models which are increasingly complicated and contrived, which depart more and more from the standard model it was supposed (...) to improve upon, and which sever the connection between cosmology and particle physics that initially made the inflationary paradigm so attractive. Nevertheless, inflationary cosmology remains a promising research program, not least because it offers an explanation of the origin of the density perturbations that seeded the formation of galaxies and other cosmic structures. Tests of this explanation are underway and may settle the issue of whether inflation played an important role in the early universe. (shrink)

The neuromodulatory effects of brain stimulation therapies notably involving repetitive transcranial magnetic stimulation on nocturnal sleep, which is critically disturbed in major depression and other neuropsychiatric disorders, remain largely undetermined. We have previously reported in major depression patients that prefrontal rTMS sessions enhanced their slow wave activity power, but not their sigma power which is related to sleep spindle activity, for electrodes located nearby the stimulation site. In the present study, we focused on measuring the spindle density to investigate (...) cumulative effects of prefrontal rTMS sessions on the sleep spindle activity. Fourteen male inpatients diagnosed with medication-resistant unipolar or bipolar depression were recruited and subjected to 10 daily rTMS sessions targeting the left dorsolateral prefrontal cortex. All-night polysomnography data was acquired at four time points: Adaptation, Baseline, Post-1, and Post-2. Clinical and cognitive evaluations were longitudinally performed at Baseline, Post-1, and Post-2 time points to explore associations with the spindle density changes. The PSG data from 12 of 14 patients was analyzed to identify sleep spindles across the sleep stages II–IV at four electrode sites: F3, F4, P3, and P4. Statistical analysis by two-way ANOVA revealed that spindle density at F3 increased at Post-1 but decreased at Post-2 time points. Moreover, the local and transient increase of spindle density at F3 was associated with the previously reported SWA power increase at F3, possibly reflecting a shared mechanism of thalamocortical synchronization locally enhanced by diurnal prefrontal rTMS sessions. Clinical and cognitive correlations were not observed in this dataset. These findings suggest that diurnal rTMS sessions transiently modulate nocturnal sleep spindle activity at the stimulation site, although clinical and cognitive effects of the local changes warrant further investigation. (shrink)

In the past ten years, work by K€olbel, MacFarlane, Richard and others has rekindled old debates on relativism. In this important contribution to those debates, the authors defend a ‘mainstream’ view about the contents of thought and talk that they call Simplicity against the assaults from such ‘analytic relativists’.

Resumen. Se presentan los conceptos básicos de muestreo secuencial en sus cinco modalidades,incluyendo muestreo secuencial de tipo estándar, usando solo una densidad crítica, por una precisiónfija, por medio de presencia-ausencia y finalmente de tipo temporal. Se notan un ejemplo real para cadacaso. Se nota y se explica la importancia de la distribución de los datos y los pertinentes ecuaciones. Sepresentan a través de ejemplos reales las ecuaciones para estimar el tamaño óptimo de la muestra paracada uno de las cinco modalidades (...) del muestreo secuencial. Se enfatiza la ventaja económica de estetipo de muestreo.Palabras clave: Distribución de los datos, muestreo secuencial, tamaño óptimo de la muestra. Fundamental concepts of sequential sampling in all its types including standard sequentialsampling, sequential sampling using only one critical density, fixed precision sequential sampling,presence-absence sequential sampling, and time sequential sampling are highlighted. A real caseexample for each of the five sequential samplings is given. The relevance of data distribution forsequential sampling along with corresponding equations is provided and explained. Equations to assessthe optimal sample size for each case are noted and exemplified. The economic advantages of sequentialsampling in stressedKeywords: Data distribution, sample size, sequential sampling. (shrink)

The subject matter of the article is a standard cosmological model of the Universe. Contemporary opinion regarding origin, structure, and evolution of the Universe is of great interest. The answer to the question of the Universe origin is given by the Big Bang Theory. Is it possible to be sure in this theory correctness, which persuading of the Universe origination from the singularity fluctuation, when the World had appeared from nowhere, that is from abstract nothingness, further accelerated expansion of the (...) Universe following the Big Bang, and its development up to present with inexplicable source of energy for that. However, in the extreme end of the meta-universe the speed of stellar formations runaway is about the light velocity. Further, there is a new problem, the finiteness of the Universe. There are two counter-opinions, if the expanding Universe is finite or infinite. A very important question arises here, the question regarding isolatedness of the Universe as a system. The problem of the Universe heat death is closely connected with it. For this reason it is the time to discuss the Universe entropy. There is a short description of notions and problems with reference to this branch of knowledge, as well as of Doppler and Ritz effects alongside with Habble Law. The authors’ detailed interpretation of an entropy is also suggested. The analysis of the existing model is followed by the idea of the authors about the Universe organization. The style of the article is popular-science. In the first part of the article the existing concept of the Expanding Universe Theory and the dynamical Friedmann-Lemaitre models are described; it deals with the existing concept of the Big Bang Theory as well as the dark energy and the dark matter notions. In the second part the author gives detailed interpretation of an entropy. In the last part the problem of theoretical basis and fact nonconformity within the Expanding Universe Model Theory and the authors’ idea about the Universe organization are considered. (shrink)

We argue that the Standard Model in the Higgs phase does not suffer from a “hierarchy problem” and that similarly the “cosmological constant problem” resolves itself if we understand the SM as a low energy effective theory emerging from a cutoff-medium at the Planck scale. We actually take serious Veltman’s “The Infrared–Ultraviolet Connection” addressing the issue of quadratic divergences and the related huge radiative correction predicted by the SM in the relationship between the bare and the renormalized theory, usually called (...) “the hierarchy problem” and claimed that this has to be cured. We discuss these issues under the condition of a stable Higgs vacuum, which allows extending the SM up to the Planck cutoff. The bare Higgs boson mass then changes sign below the Planck scale, such that the SM in the early universe is in the symmetric phase. The cutoff enhanced Higgs mass term as well as the quartically enhanced cosmological constant term provide a large positive dark energy that triggers the inflation of the early universe. Reheating follows via the decays of the four unstable heavy Higgs particles, predominantly into top–antitop pairs, which at this stage are massless. Preheating is suppressed in SM inflation since in the symmetric phase bosonic decay channels are absent at tree level. The coefficients of the shift between bare and renormalized Higgs mass as well as of the shift between bare and renormalized vacuum energy density exhibit close-by zeros at about \ and \, respectively. The zero of the Higgs mass counter term triggers the electroweak phase transition, from the low energy Higgs phase and to the symmetric phase above the transition point. Since inflation tunes the total energy density to take the critical value of a flat universe and all contributing components are positive, it is obvious that the cosmological constant today is naturally a substantial fraction of the total critical density. Thus taking cutoff enhanced corrections seriously the Higgs system provides besides the masses of particles in the Higgs phase also dark energy, inflation and reheating in the early universe. The main unsolved problem in our context remains the origin of dark matter. Higgs inflation is possible and likely even unavoidable provided new physics does not disturb the known relevant SM properties substantially. The scenario highly favors to understand the SM and its main properties as a natural structure emerging at long distance. This in particular concerns the SM symmetry patterns and their consequences. (shrink)

I criticize some arguments against the causal interpretability of population genetics put forward by Denis Walsh ([2007], [2010]). In particular, I seek to undermine the contention that population genetics exhibits frame of reference relativity or subjectivity with respect to its formal representations. I also show that classical population genetics does not fall foul of some criteria for causal representation put forward by James Woodward ([2003]), although those criteria do undermine some causalist stances. 1 Introduction2 Modularity3 The Crucially Important Point4 The (...) Gillespie Case: Density-Dependent Selection5 Conclusion. (shrink)

The paper examines critically some recently published views by Ramsey on the contrast between ab initio and parametrized theories. I argue that, all things being equal, ab initio calculations are indeed regarded more highly in the physics and chemistry communities. A case study on density functional approaches in theoretical chemistry is presented in order to re‐examine the question of ab initio and parametrized approaches in a contemporary context.

This article develops an analogy proposed by Stachel between general relativity (GR) and quantum mechanics (QM) as regards permutation invariance. Our main idea is to overcome Pooley's criticism of the analogy by appeal to paraparticles. In GR, the equations are (the solution space is) invariant under diffeomorphisms permuting spacetime points. Similarly, in QM the equations are invariant under particle permutations. Stachel argued that this feature—a theory's ‘not caring which point, or particle, is which’—supported a structuralist ontology. Pooley criticizes this analogy: (...) in QM the (anti-)symmetrization of fermions and bosons implies that each individual state (solution) is fixed by each permutation, while in GR a diffeomorphism yields in general a distinct, albeit isomorphic, solution. We define various versions of structuralism, and go on to formulate Stachel's and Pooley's positions, admittedly in our own terms. We then reply to Pooley. Though he is right about fermions and bosons, QM equally allows more general types of particle symmetry, in which states (vectors, rays, or density operators) are not fixed by all permutations (called ‘paraparticle states’). Thus Stachel's analogy is revived. (shrink)

Although at times criticized for its philosophical density, French cultural theory remains a flourishing, if highly contested, area of academic study. Four feminist thinkers in this tradition continue to be especially prominent: Simone de Beauvoir, Julia Kristeva, Hélène Cixous, and Luce Irigaray. This new collection from Routledge gathers together the very best secondary literature on these thinkers to provide an indispensable conspectus of their works. Each of the four thinkers is represented by an individual volume, and each volume includes (...) a newly written introduction to that thinker’s work and her philosophical relevance. (shrink)

Little is known about how and why corporate social responsibility (CSR) emerged in lesser developed countries. In order to address this knowledge gap, we used Chile as a test case and conducted a series of in-depth interviews with leaders of CSR initiatives. We also did an Internet and literature search to help provide support for the findings that emerged from our data. We discovered that while there are similarities in the drivers of CSR in developed countries, there are distinct differences (...) as well. In particular, we found that different sectors drive CSR in Chile. In contrast to other geographies where consumer demand and government regulation provided the impetus for CSR efforts, multinational companies (MNCs) and non-governmental organizations (NGOs) are key actors in Chile. MNCs imported their CSR beliefs, skills, and processes into Chile. Their efforts resulted in a virtuous cycle. Once large domestic firms felt pressured by their MNC rivals, they too adopted CSR initiatives. The ability to manage relationships with multiple stakeholders and perceptions of authenticity were also critical to the success of CSR in Chile. Using network theory as a lens, we suggest that network density and centrality largely determine whether CSR efforts will be authentic. Based on these contentions, we suggest avenues for future research. (shrink)

The status of the vacuum in relativistic quantum field theory is examined. A sharp distinction arises between the global vacuum and the local vacuum. The concept of local number density is critically assessed. The global vacuum state implies fluctuations for all local observables. Correlations between such fluctuations in space-like separated regions of space-time are discussed and the existence of correlations which are maximal in a certain sense is remarked on, independently of how far apart those regions may be. The (...) analogy with the mirror-image correlations in the singlet state of two spin-1/2 particles is explained. The connection between these maximal correlations and the well-known violation of the Bell inequality in the vacuum state is discussed, together with the way in which the existence of these correlations might be exploited in developing a vacuum version of the Einstein-Podolsky-Rosen argument. The recent relativistic formulation of the Einstein-Podolsky-Rosen argument by Ghirardi and Grassi is critically assessed with particular reference to the vacuum case. (shrink)

It is shown that Lewis’ ontological doctrine of Humean supervenience incorporates at its foundation the so-called separability principle of classical physics. In view of the systematic violation of the latter within quantum mechanics, the claim that contemporary physical science may posit non-supervenient relations beyond the spatiotemporal ones is reinforced on a foundational basis concerning constraints on the state representation of physical systems. Depending on the mode of assignment of states to quantum systems — unit state vectors versus statistical density (...) operators — we distinguish between strongly and weakly non-Humean, non-supervenient relations. It is demonstrated that in either case, the relations of quantum entanglement constitute prototypical examples of irreducible physical relations that do not supervene upon a spatiotemporal arrangement of Humean qualities, weakening, thereby, the thesis of Humean supervenience. In this respect, the status of Lewis’ recombination principle is examined, whereas his conception of lawhood is critically investigated. It is concluded that the assumption of ontological reductionism, as expressed in Lewis’ Humean doctrine, cannot be regarded as a reliable code of the nature of the physical world and its contents. It is proposed instead that due to the undeniable existence of non-supervenient relations, a metaphysic of relations of a moderate kind ought to be acknowledged as an indispensable part of our understanding of the natural world at a fundamental level. (shrink)

Some interpretations of quantum mechanics regard a mixed quantum state as a ensemble, each individual member of which has a definite but unknown state vector. Other interpretations ascribe a state vector only to anensemble of similarly prepared systems, but not to anindividual. Previous attempts to detect the hypothetical individual state vectors have failed, essentially because the state operator enters the relevant equations linearly. An example from nonlinear dynamics, in which a density matrix enters nonlinearly, is examined because it might (...) appear to circumvent this difficulty. However, it is shown that the hypothetical individual state vectors can not be detected this way, so the adequacy of theensemble interpretation survives a critical test. (shrink)

This thesis is an attempt to reconstruct the conceptual foundations of quantum mechanics. First, we argue that the wave function in quantum mechanics is a description of random discontinuous motion of particles, and the modulus square of the wave function gives the probability density of the particles being in certain locations in space. Next, we show that the linear non-relativistic evolution of the wave function of an isolated system obeys the free Schrödinger equation due to the requirements of spacetime (...) translation invariance and relativistic invariance. Thirdly, we argue that the random discontinuous motion of particles may lead to a stochastic, nonlinear collapse evolution of the wave function. A discrete model of energy-conserved wavefunction collapse is proposed and shown to be consistent with existing experiments and our macroscopic experience. In addition, we also give a critical analysis of the de Broglie-Bohm theory, the many-worlds interpretation and other dynamical collapse theories, and briefly discuss the issue of unifying quantum mechanics and special relativity. (shrink)

I have two primary aims in the following paper, aims that are inextricably intertwined. First, I want to raise some historiographical and epistemological issues about how to write the history of psychoanalysis. Although they arise quite generally in the history of science, these issues have a special status and urgency when the domain is the history of psychoanalysis. Second, in light of the epistemological and methodological orientation that I am going to advocate, I want to begin a reading of Freud’s (...) Three Essays on the Theory of Sexuality, one whose specificity is a function of my attachment to this orientation, to a particular way of doing the history of psychoanalysis. Despite the enormous number of pages that have been written on Freud’s Three Essays, it is very easy to underestimate the density of this book, a density at once historical, rhetorical, and conceptual. This underestimation stems in part from historiographical presumptions that quite quickly misdirect us away from the fundamental issues.In raising question about the historiography of the history of science, I obviously cannot begin at the beginning. So let me begin much further along, with the writings of Michel Foucault. I think of the works of Foucault, in conjunction with that of Gaston Bachelard and Georges Canguilhem, as exemplifying a very distinctive perspective about how to write the history of science. In the English-speaking world, perhaps only the work of Ian Hacking both shares this perspective and ranks with its French counterparts in terms of originality and quality. No brief summary can avoid eliding the differences between Bachelard, Canguilhem, Hacking, and Foucault; indeed, the summary I am going to produce does not even fully capture Foucault’s perspective, which he called “archaeology.”1 But this sketch will have to do for the purposes I have in mind here, whose ultimate aim is to reorient our approach to the history of psychoanalysis. 1. The sketch that follows reproduces, with some omissions and additions, the beginning of my “Archeology, Genealogy, Ethics,” in Michel Foucault: A Critical Reader, ed. David Hoy , pp. 221-34. Arnold I. Davidson is assistant professor in the department of philosophy, the Committee on the Conceptual Foundations of Science, and the Committee on General Studies in the Humanities at the University of Chicago. He is currently writing a book on the history and epistemology of nineteenth-century psychiatric theories of sexuality. (shrink)

A recent development in the philosophy of religion has been the attempt to justify belief in God using Bayesian confirmation theory. My dissertation critically discusses two prominent spokesmen for this approach--Richard Swinburne and J. L. Mackie. Using probabilistic confirmation theory, these philosophers come to wildly divergent conclusions with respect to the hypothesis of theism; Swinburne contends that the evidence raises the overall probability of the hypothesis of theism, whereas Mackie argues that the evidence disconfirms the existence of God. After a (...) careful analysis of the individual authors, this dissertation critically examines the assumptions of the project. The authors consider arguments for the existence of God separately--the cosmological argument, the argument from design, apparent miracles, the problem of evil, and arguments from religious experience--and then conjoin them to assess the cumulative effect of the arguments. The assumptions are that the probability calculus may be interpreted for a successful inductive argument for or against the existence of God, that inference to best explanation is applicable to the justification of religious belief, that the justification of belief in God is analogous to the justification of a scientific theory, and that a classical foundationalist conception of rationality is correct. It is the contention of this dissertation that all of these assumptions are incorrect. All of the major interpretations of the probability calculus are examined and it is argued that there are either no interpretations for the probability assignments or no interpretations which will advance an argument for or against the existence of God. It is also argued that the usual methods for interpreting the explanatory power of theism will not determine any non-zero probabilities; however, density measuring will provide a non-zero interpretation. In the final chapter it is argued that a subjective Bayesian conception of rationality is neither a necessary nor a sufficient condition of rationality and that classical foundationalism is self-referentially inconsistent. An alternative approach to the rationality of religious belief is offered that proceeds along Reidian and Plantingan lines, belief in God is properly basic. (shrink)

According to Kant, justifying the application of mathematics to objects in natural science requires metaphysically constructing the concept of matter. Kant develops these constructions in the Metaphysical Foundations of Natural Science (MAdN). Kant’s specific aim is to develop a dynamic theory of matter to replace corpuscular theory. In his Preface Kant claims completely to exhaust the metaphysical doctrine of body, but in the General Remark to MAdN ch. 2, “Dynamics,” Kant admits that once matter is reconceived as basic forces, it (...) is no longer possible to construct the concept of matter. I argue that Kant’s admission is only the tip of the problem, and that none of Kant’s commentators has fully grasped the problems infecting the MAdN that underlie Kant’s admission. I show that Kant’s proof that matter consists of forces is fallacious. I then re-analyze the circularity in Kant’s definition of density, criticizing both Adickes’ formulations and his later dissolution of it. I also show that a third circularity infects the relations between Kant’s treatment of “Dynamics” and “Mechanics” (MAdN ch. 3). These three fundamental problems demonstrate the untenability of Kant’s metaphysical method, and they require the radical revision of the relation between mathematics and metaphysics Kant undertakes in his opus postumum. I show that some of Kant’s most surprising and critical later claims about the Critical philosophy are correct, and that they require the sorts of remedies Kant contemplates in the opus postumum. (I defend the essentially correct analyses offered by Burkhard Tuschling and Eckart Forster against criticisms by Michael Friedman.). (shrink)

We discuss the content and significance of John von Neumann’s quantum ergodic theorem (QET) of 1929, a strong result arising from the mere mathematical structure of quantum mechanics. The QET is a precise formulation of what we call normal typicality, i.e., the statement that, for typical large systems, every initial wave function ψ0 from an energy shell is “normal”: it evolves in such a way that |ψt ψt| is, for most t, macroscopically equivalent to the micro-canonical density matrix. The (...) QET has been mostly forgotten after it was criticized as a dynamically vacuous statement in several papers in the 1950s. However, we point out that this criticism does not apply to the actual QET, a correct statement of which does not appear in these papers, but to a different (indeed weaker) statement. Furthermore, we formulate a stronger statement of normal typicality, based on the observation that the bound on the deviations from the average specified by von Neumann is unnecessarily coarse and a much tighter (and more relevant) bound actually follows from his proof. (shrink)

Psychedelics have been recognized as model interventions for studying altered states of consciousness. However, few empirical studies of the shamanic state of consciousness, which is anecdotally similar to the psychedelic state, exist. We investigated the neural correlates of shamanic trance using high-density electroencephalography (EEG) in 24 shamanic practitioners and 24 healthy controls during rest, shamanic drumming, and classical music listening, followed by an assessment of altered states of consciousness. EEG data were used to assess changes in absolute power, connectivity, (...) signal diversity, and criticality, which were correlated with assessment measures. We also compared assessment scores to those of individuals in a previous study under the influence of psychedelics. Shamanic practitioners were significantly different from controls in several domains of altered states of consciousness, with scores comparable to or exceeding that of healthy volunteers under the influence of psychedelics. Practitioners also displayed increased gamma power during drumming that positively correlated with elementary visual alterations. Furthermore, shamanic practitioners had decreased low alpha and increased low beta connectivity during drumming and classical music and decreased neural signal diversity in the gamma band during drumming that inversely correlated with insightfulness. Finally, criticality in practitioners was increased during drumming in the low and high beta and gamma bands, with increases in the low beta band correlating with complex imagery and elementary visual alterations. These findings suggest that psychedelic drug-induced and non-pharmacologic alterations in consciousness have overlapping phenomenal traits but are distinct states of consciousness, as reflected by the unique brain-related changes during shamanic trance compared to previous literature investigating the psychedelic state. (shrink)

Aggregation methods allow one to replace a large scale dynamical system (micro-system) by a reduced dynamical system (macro-system) governing a small number of global variables. This aggregation of variables can be performed when two time scales exist, a fast time scale and a slow time scale. Perturbation theory allows to obtain an approximated aggregated dynamical system which describes the behaviour of a few number of slow time varying variables which are constants of motion of the fast part of the micro-system. (...) Aggregation methods are applied to the case of the devastation of the great barrier reef by the starfishes. We recall the Antonelli/Kazarinoff model which implies a stable limit cycle for the corals and starfish populations. This prey-predator model describes the interactions between two species of corals and the starfish. Then, we generalize the Antonelli/Kazarinoff model to the case of two spatial patches with a fast part describing the starfish migration on the patches and the human manipulation of the communities by divers and, a slow part describing the growth and the interactions between the populations. We obtain an aggregated model governing the total coral densities on the patches and the total starfish population. This model can exhibit stable limit cycle oscillations and a Hopf bifurcation. The critical value of the bifurcation parameter is expressed in terms of the proportions of coral species and starfish on the two patches. This implies for example that rather than random killing of starfish by the Australian military, it may be better to send teams of divers to outbreaking reefs when they first occur who will then manipulate the community structure to increase protection. (shrink)

From a certifier’s perspective, this paper deals with the question of how to bring together the values of producers and consumers in globalized food markets. It is argued that growth and mainstreaming of organic food production cannot be achieved solely by ethically aware consumers signalling their more sustainable purchase decision to the market. In fact, the intrinsic motivation of producers is an indispensable requisite for such a development. It is then the organic movement’s and the certifier’s task to bring together (...) the values of consumers and producers. This challenge is explored in the following by using the example of organic aquaculture. Based on one of the author’s experience in the field of aquaculture certification since the late 1990s, in about twenty countries and with most aquaculture animal species, the paper examines critical value-based aspects that are prominent from the perspective of sustainability. These are: use of problematic substances in aquaculture production, stocking density, origin of feedstuff, certification procedure, and small-scale farming versus large aquaculture companies. On this basis, the paper describes and analyses attempts to formulate respective organic certification standards. In order to bring about organic aquaculture, it is argued that consumers’ choices alone are not sufficient and that successful transformation to sustainable aquaculture also needs to take into account values and preferences of producers. (shrink)

Cell membranes experience frequent stretching and poking: from cytoskeletal elements, from osmotic imbalances, from fusion and budding of vesicles, and from forces from the outside. Are the ensuing changes in membrane tension localized near the site of perturbation, or do these changes propagate rapidly through the membrane to distant parts of the cell, perhaps as a mechanical mechanism of long‐range signaling? Literature statements on the timescale for membrane tension to equilibrate across a cell vary by a factor of ≈106. This (...) study reviews and discusses how apparently contradictory findings on tension propagation in cells can be evaluated in the context of 2D hydrodynamics and poroelasticity. Localization of tension in the cell membrane is likely critical in governing how membrane forces gate ion channels, set the subcellular distribution of vesicle fusion, and regulate the dynamics of cytoskeletal growth. Furthermore, in this study, it is proposed that cells can actively regulate the degree to which membrane tension propagates by modulating the density and arrangement of immobile transmembrane proteins. Also see the video abstract here https://youtu.be/T6K7AIAqqBs. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Radicalizing the Local: 60 Linear Miles of Transborder ConflictTeddy Cruz (bio)2008estudio teddy cruzmedium: collage and vinyl wallpaperThe international border between the US and Mexico at the San Diego-Tijuana checkpoint is one of the most trafficked in the world. A 60-linear-mile cross-section—tangential to the border wall—between these two border cities compresses the most dramatic issues currently challenging our normative notions of architecture and urbanism.This transborder “cut” begins 30 miles north (...) of the border, on the periphery of San Diego, and ends 30 miles south of the border. We can find along this section’s trajectory a series of collisions, critical junctures, or conflicts between natural and artificial ecologies, top-down development and bottom-up organization. It is in the midst of many of these metropolitan and territorial sites of conflict where contemporary architectural practice needs to reposition itself.1. Conflict between master-planned gated communities and the natural topography +30 miles / San DiegoTop-down private development has been installing a selfish, oil-hungry sprawl of detached McMansions everywhere, forming massive subdivisions that collide with the natural topography.2. Conflict between large infrastructure and the watershed +28 miles / San DiegoLarge freeway and mall infrastructure runs the length of coastal San Diego, colliding with a natural network of canyons, rivers, and creeks that descend toward the Pacific Ocean.3. Conflict between privatization and everyday life +25 miles / San DiegoThe archipelago of beige tract homes also exacerbates a land use of exclusion, leading to an apartheid of everyday life, as gated communities retreat from the complexities of mixed uses.4. Conflict between military bases and environmental zones +20 miles / San DiegoIronically, the only interruptions along an otherwise continuous sprawl, 30 miles inland from the border, occur as the military bases that dot San Diego’s suburbanization overlap with environmentally protected lands.5. Conflict between the formal and informal +15 miles / San DiegoThe informal densities and economies produced by immigrants yield three-dimensional land use that collides with the one-dimensional zoning that defines suburban tract subdivisions. [End Page 107]6. Conflict between two border cities 0 miles / San Diego-TijuanaThis territorial conflict is currently dramatized by the hardening of the border wall that divides these cities, incrementally transforming San Diego into the world’s largest gated community.7. Conflict between the natural and political +0.5 miles / TijuanaAs the large infrastructure of the Tijuana River clashes with the border wall, a faint yellow line is inscribed on the dry river’s concrete channel to indicate the trajectory of the border. The border checkpoint is exactly at this intersection.8. Conflict between the informal and natural ecologies-10 miles / TijuanaAdjacent to the checkpoint we can find many slums crashing against the border. The wall acts as a powerful dam, containing the density of Tijuana and preventing it from contaminating San Diego’s picturesque sprawl.9. Conflict between factories and emergency housing-15 miles / TijuanaThese American-style, mini-master-planned communities are intertwined with a series of informal communities or slums, and both provide maquiladora factory enclaves with cheap labor.10. Conflict between density and sprawl-20 miles / TijuanaThousands of miniaturized replicas of typical suburban Southern California McMansions are now scattered around the periphery of Tijuana. In recent years, dwellers have radically transformed them into socioeconomic microengines.11. Conflict between two horizons-30 miles / TijuanaAs we reach the sea on the Mexican side, we witness the most dramatic of all territorial collisions across this 60-mile-section of local conflict. Here, the border metal fence finally sinks into the Pacific Ocean. [End Page 108] Click for larger view View full resolution[End Page c1] Click for larger view View full resolution[End Page 2] Click for larger view View full resolution[End Page 12] Click for larger view View full resolution[End Page 22] Click for larger view View full resolution[End Page 32] Click for larger view View full resolution[End Page 42] Click for larger view View full resolution[End Page 52] Click for larger view View full resolution[End Page 62] Click for larger view View full resolution[End Page... (shrink)

This paper discusses a deterministic model of the spread of an infectious disease in a closed population that was proposed byKermack &McKendrick . The mathematical assumptions on which the model is based are listed and criticized. The ‘threshold theorem’ according to which an epidemic develops if, and only if, the initial population density exceeds a certain value determined by the parameters of the model, is discussed. It is shown that the theorem is not true. A weaker result is stated (...) and proved.A new simplified version of the model is discussed. In this model it is assumed that an infected individual becomes infectious after a constant time and that it will removed after a constant time. Numerical simulations of this model show that the form of the fluctuations in the number of diseased individuals depends on the values of the parameters. The number of infectious individuals may oscillate up and down under certain circumstances. Necessary conditions for the number of infectious individuals to rise above previous levels are stated and proved. (shrink)

Many abiotic and other signals are transduced in eukaryotic cells by changes in the level of free calcium via pumps, channels and stores. We suggest here that ion condensation should also be taken into account. Calcium, like other counterions, is condensed onto linear polymers at a critical value of the charge density. Such condensation resembles a phase transition and has a topological basis in that it is promoted by linear as opposed to spherical assemblies of charges. Condensed counterions (...) are delocalised and can diffuse in the so‐called near region along the polymers. It is generally admitted that cytoskeletal filaments, proteins colocalised with these filaments, protein filaments distinct from cytoskeletal filaments, and filamentous assemblies of other macromolecules, constitute an intracellular macromolecular network. Here we draw attention to the fact that this network has physicochemical characteristics that enable counterion condensation. We then propose a model in which the feedback relationships between the condensation/decondensation of calcium and the activation of calcium‐dependent kinases and phosphatases control the charge density of the filaments of the intracellular macromolecular network. We show how condensation might help mediate free levels of calcium both locally and globally. In this model, calcium condensation/decondensation on the macromolecular network creates coherent patterns of protein phosphorylation that integrate signals. This leads us to hypothesize that the process of ion condensation operates in signal transduction, that it can have an integrative role and that the macromolecular network serves as an integrative receptor. BioEssays 26:549–557, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

Languages show substantial variability between their speakers, but it is currently unclear how the structure of the communicative network contributes to the patterning of this variability. While previous studies have highlighted the role of network structure in language change, the specific aspects of network structure that shape language variability remain largely unknown. To address this gap, we developed a Bayesian agent‐based model of language evolution, contrasting between two distinct scenarios: language change and language emergence. By isolating the relative effects of (...) specific global network metrics across thousands of simulations, we show that global characteristics of network structure play a critical role in shaping interindividual variation in language, while intraindividual variation is relatively unaffected. We effectively challenge the long‐held belief that size and density are the main network structural factors influencing language variation, and show that path length and clustering coefficient are the main factors driving interindividual variation. In particular, we show that variation is more likely to occur in populations where individuals are not well‐connected to each other. Additionally, variation is more likely to emerge in populations that are structured in small communities. Our study provides potentially important insights into the theoretical mechanisms underlying language variation. (shrink)

We applaud Notini and colleagues for highlighting the clinical and ethical complexities of a case in which a non-binary individual desires indefinite treatment with puberty blockers.1 While we agree discontinuing treatment may cause psychological distress, we believe there are potential physical and neurocognitive harms caused by prolonged treatment that have been underestimated given the limited research conducted to date. Specifically, the impact of permanent pubertal suppression on the brain and decision-making capacity should be considered. In this context, we outline the (...) potential risks of ongoing pubertal suppression on bone and cardiovascular health, sexual and reproductive function, and brain development—all noted in the article but perhaps in an overly simplistic manner.1 First, the authors’ note OPS will almost certainly result in reduced bone density.1 Although we agree the absolute fracture risk is low in studies among older adults, there is less clarity about implications during adolescence and young adulthood when peak bone accrual occurs.2 Further, the authors propose ongoing monitoring with bone density scans, but no clear guidelines for clinicians if bone density becomes critically low—so we ask, at what point would a potential fracture risk outweigh the proposed benefits …. (shrink)

Ernesto Laclau’s Marxist and post-Marxist works are best understood when they are embedded in the history of Argentina’s National Left. This socialist-populist current underpinned his strategic horizons onward of at least 1963. While purely theoretical interpretations of Laclau can sometimes be enlightening, they tend to lose sight of the historical density of the Argentine’s thought. Over the course of his working life, Laclau’s theories presented the Argentinean Left with a challenge concerning how to engage with Peronism: specifically, how to (...) develop a leftist hegemonic project in an era when the working class remained stubbornly linked to a Peronist political identity. Laclau’s political trajectory and his understanding of Marxism are analysed here in order to explain the nature of his post-Marxism. (shrink)

This exhaustively-researched, carefully-focused book asks whether imagination, emotion and art can enlighten our sense of right and wrong, looking at this question through the lens of moral philosophy with contributions from cognitive science, psychology and neurology. If moral thinking is simply logical reasoning or following God-given law, why did the poet Shelley say that “the great instrument of moral good is the imagination”? Why does ethical reasoning tend towards absolutes: something is either right or wrong, period, while a thoughtful minority (...) values the “priority of the particular” – that unique aspects of a situation may come closer to the heart of the matter than any general rules could? Are emotions, as many philosophers in history have theorized, only a distraction from the clear perception of duty, or do feelings add something important, even critical, to how we judge good and bad, right and wrong? Can great works of art and literature embody imagination, the particular, and emotions to illuminate human life in ways crucial to ethical thinking? This book introduces an original idea in philosophy, “moral density,” which for the first time elucidates the profound relation between art and ethics. Written for the literate layperson, an academic or technical background is not necessary, so this book will be of interest not only to philosophers and educators, but to all who are concerned with what is good, and how to see it and teach it. (shrink)

A simple model, illustrating the transition from a population of free swimming, solitary cells to one consisting of small colonies serves as a basis to discuss the evolution of the cooperative group. The transition is the result of a mutation of the dynamics of cell division, delayed cell separation leads to colonies of four cells. With this mutation cooperative features appear, such as synchronised cell divisions within colonies and coordinated flagellar function which enables the colony to swim in definite directions. (...) The selective advantages under given, environmental conditions are defined and the periods necessary for complete allelic replacement in small populations are calculated for asexual and sexual reproduction. The assumption of a steady-state population during allelic substitution is critically considered, particularly under conditions of competition. It is shown that density-dependent population control must operate in the process of selection. Sexual reproduction slows down the rate of selection even though all cells dre haploid. This phenomenon can be explained in general terms of `organizational dominance', where individual units coordinate the function of their neighbours which may be of a different allelotype.Cooperativity is pointed out as an a priori systemic feature which resides in the sub-units of systems, group formation and coordination appears thus as an almost inevitable event. A particular type of system described as ‘closed cycle of positive fitness interaction’ is discussed in more detail. It has the remarkable feature that its members cannot compete with each other; selection takes place between whole cycles .Gonium has a wide spectrum of `somatic plasticity' which enables it to assume various colonial configurations depending on physiological and environmental conditions. This feature can be explained as the result of dynamic flexibilities on the macro-molecular level. The particular relationship between the vast, molecular complexity and the relative simple dynamics of the cell cycle must lead eventually to the genetic fixation of an environmentally induced phenotype. (shrink)