Using this case, Lavazza and Reichlin (2018) explored the ethical dilemmas associated with decision making in people with Alzheimer’s disease (AD), specifically when their new preferences conflict...

Bioethics, Volume 36, Issue 1, Page 25-41, January 2022.

There has been a surge in mass media reports extolling the potential for using three-dimensional printing of biomaterials to treat a wide range of clinical conditions. Given that mass media is recognized as one of the most important sources of health and medical information for the general public, especially prospective patients, we report and discuss the ethical consequences of coverage of 3D bioprinting in the media. First, we illustrate how positive mass media narratives of a similar biofabricated technology, namely the (...) Macchiarini scaffold tracheas, which was involved in lethal experimental human trials, influenced potential patient perceptions. Second, we report and analyze the positively biased and enthusiastic portrayal of 3D bioprinting in mass media. Third, we examine the lack of regulation and absence of discussion about risks associated with bioprinting technology. Fourth, we explore how media misunderstanding is dangerously misleading the narrative about the technology. (shrink)

The phenomenological effects of deep brain stimulation (DBS) on the self of the patient remains poorly understood and under described in the literature, despite growing evidence that a significant number of patients experience postoperative neuropsychiatric changes. To address this lack of phenomenological evidence, we conducted in-depth, semistructured interviews with 17 patients with Parkinson's disease who had undergone DBS. Exploring the subjective character specific to patients' experience of being implanted gives empirical and conceptual understanding of the potential phenomenon of DBS-induced self-estrangement. (...) Our study concluded that (1) the more patients preoperatively felt alienated by their illness, the more they experienced postoperative self-estrangement, and (2) the notion of self-estrangement seems to exist in association with certain common qualitative characters, namely, loss of control, which reflects a deteriorative estrangement, and distorted perception of capacities, which reveals a restorative estrangement. These findings indicate that subjective self-reports help us to understand some aspects of the potential phenomenon of DBS-induced self-estrangement. (shrink)

To conclude that there is enough or not enough evidence demonstrating that deep brain stimulation causes unintended postoperative personality changes is an epistemic problem that should be answered on the basis of established, replicable, and valid data. If prospective DBS recipients delay or refuse to be implanted because they are afraid of suffering from personality changes following DBS, and their fears are based on unsubstantiated claims made in the neuroethics literature, then researchers making these claims bear great responsibility for prospective (...) recipients' medical decisions and subsequent well-being. Our article “Deflating the ‘DBS causes personality’ bubble” reported an increase in theoretical neuroethics publications suggesting putative DBS-induced changes to personality, identity, agency, autonomy, authenticity and/or self and a critical lack of supporting primary empirical studies. This special issue of Neuroethics brings together responses to our initial publication, with our own counter-responses organized according to common themes. We provide a brief summary for each commentary and its main criticisms as well as a discussion of the way in which these responses can: 1) help clarify the meaning of PIAAAS, suggesting supplementary frameworks for understanding the impact of DBS on PIAAAS; 2) provide further empirical evidence of PIAAAS by presenting results from the researchers’ own work; and/or 3) offer a critique of our research approach and/or findings. Unintended postoperative putative changes to PIAAAS remain a critical ethical concern. It is beyond dispute that we need to develop reliable empirical and conceptual instruments able to measure complex cognitive, affective, and behavioural changes in order to investigate whether they are attributable to DBS alone. (shrink)

Jecker et al. (2024) propose seven ethical principles to guide international bioethics conferencing, applying them to the selection of Qatar as the location for the 2024 World Congress of Bioethics...

Volume 20, Issue 4, May 2020, Page 94-97.

Galasso (2024) reiterates the problem of medical research being grounded on data from people with European ancestry and subsequently describes efforts made by the All of Us Research Program in the...

Volume 20, Issue 8, August 2020, Page 101-104.

COVID-19 has disproportionately affected ethnic minorities and migrants, not only through an increased risk of infection and death (Pan et al. 2020), but also through experiences of harassment, mar...

Recent outbreaks in Australia and the detection of more virulent SARS‐CoV‐2 strains suggest that Covid‐19 is not yet over. In July 2021, three states in Australia were in lockdown as a result of community transmission of the Delta variant. Despite being effective at mitigating outbreaks, lockdowns could have adverse effects on the elderly and people with dementia. This commentary reviews general lockdown and aged‐care lockdown policies in Victoria, New South Wales, and South Australia and highlights how these could affect the (...) well‐being of people with dementia and their caregivers. Drawing from literature on Covid‐19 and dementia, this commentary provides pragmatic recommendations on how to consider the well‐being of people with dementia and their care providers in Covid‐19 management policies. (shrink)

Many real-world agents recognise that they impose harms by choosing to emit carbon, e.g., by flying. Yet many do so anyway, and then attempt to make things right by offsetting those harms. Such offsetters typically believe that, by offsetting, they change the deontic status of their behaviour, making an otherwise impermissible action permissible. Do they succeed in practice? Some philosophers have argued that they do, since their offsets appear to reverse the adverse effects of their emissions. But we show that (...) they do not. In practice, standard carbon offsetting does not reverse the harms of the original action, nor does it even benefit the same group as was harmed. Standard moral theories hence deny that such offsetting succeeds. Indeed, we show that any moral theory that allows offsetting in this setting faces a dilemma between allowing any wrong to be offset, no matter how grievous, and recognising an implausibly sharp discontinuity between offsettable actions and non-offsettable actions. The most plausible response is to accept that carbon offsetting fails to right our climate wrongs. (shrink)

Since 2007, a team of American and British ancient historians has been preparing a new translation of theCodex Justinianus. The ‘Codex Project’ was launched by chief editor Bruce W. Frier; the goal of the project is to create the first reliable English translation of theCodex Justinianuson the basis of the standard edition by Paul Krüger. Since 1932, the notoriously unreliable translation by Scott has remained the only one in English. The new translation by the Codex Project should appear soon.

The Enron debacle, the demise of Arthur Andersen, questionable practices at Tyco, Qwest, WorldCom, and a seemingly endless list of others have pushed public regard for business and business leaders to new lows. The need for smart leaders with vision and integrity has never been greater. Things need to change-- and it will not be easy. We can take a first step toward producing better business leaders by changing some of our own ideas about what it means to "win." (...) class='Hi'>Noel M. Tichy and Andrew R. McGill have brought together a stellar group of contributors from a variety of perspectives-- including General Electric CEO Jeffrey Immelt, former Secretary of State James A. Baker III, and renowned management gurus Robert Quinn and C. K. Prahalad, among others-- to offer insights that will help build better leaders, communities, and organizations. They show how to present a "Teachable Point of View" about business ethics that will help all leaders within an organization: Internalize core values Build a values-based culture across the organization Become engaged to teach the same values lessons to their staff Take action and raise the ethical bar Successful business leaders must be able to articulate their own unique Teachable Point of View on business ethics and drive it through their organization to ensure that everyone knows the ethical line and is neither shy nor silent if others risk crossing it. (shrink)

This chapter starts from the claim that the state is plagued with problems of political short-termism: excessive priority given to near-term benefits at the expense of benefits further in thefuture. One possible mechanism to reduce short-termism involves apportioning greater relative political influence to the young, since younger citizens generally have greater additional life expectancy than older citizens and thus it looks reasonable to expect that they have preferences that are extended further into the future. But the chapter shows that this (...) is unlikely to make states significantly less short-termist: no empirical relationship has been found between age and willingness to support long-termist policies. Instead, the chapter proposes a more promising age-based mechanism. States should develop youth citizens’ assemblies that ensure accountability to future generations through a scheme of retrospective accountability. (shrink)

Waiting time is widely used in health and social policy to make resource allocation decisions, yet no general account of the moral significance of waiting time exists. We provide such an account. We argue that waiting time is not intrinsically morally significant, and that the first person in a queue for a resource does not ipso facto have a right to receive that resource first. However, waiting time can and sometimes should play a role in justifying allocation decisions. First, there (...) is a duty of fairness prohibiting line-cutting where a sufficiently just queue exists. Second, waiting time has several morally attractive features that can justify its incorporation into allocation schemes. Where candidates are in relevantly similar circumstances, allocating by waiting time is relatively efficient, maximizes distribution equality relative to other Pareto efficient distributions, and treats candidates fairly. The claim that allocation using waiting time is fair is controversial. Some have claimed that formal lotteries are a fairer way to select among equal beneficiaries. We argue that lotteries are no fairer than allocation based on waiting time when it is equiprobable how a prospective queue will be ordered. In practice, lotteries share many of the disadvantages of queues; which is fairer will depend on contingent features of the allocation scenario. The upshot is that first-come, first-served is in fact a just way to allocate resources in many of the cases where it seems pre-theoretically compelling, and waiting time has unique normative properties which frequently justify its incorporation into resource allocation schemes. (shrink)

One widely used method for allocating health care resources involves the use of cost-effectiveness analysis (CEA) to rank treatments in terms of quality-adjusted life-years (QALYs) gained. CEA has been criticized for discriminating against people with disabilities by valuing their lives less than those of non-disabled people. Avoiding discrimination seems to lead to the ’QALY trap’: we cannot value saving lives equally and still value raising quality of life. This paper reviews existing responses to the QALY trap and argues that all (...) are problematic. Instead, we argue that adopting a moderate form of prioritarianism avoids the QALY trap and disability discrimination. (shrink)

Enclosed is a guidebook for philanthropists, advocates, and policymakers who want to do the most good possible. This book introduces the philosophy of “longtermism,” the idea that it is particularly important that we act now to safeguard future generations. -/- The future is vast in scale: depending on our choices in the coming centuries, the future could stretch for eons or it could dwindle into oblivion, and be inordinately good or inordinately bad. And yet future generations are utterly disenfranchised in (...) the world today: they cannot participate in our markets, our movements, or our civil society. This presents 21st Century philanthropists with a historically unprecedented opportunity to do good by protecting the long-term future. -/- The essays within are from the pioneers who have developed the intellectual foundations of longtermism, as well as the experts and advocates who are now putting it into practice. Readers will hear the case for longtermism from professors at the University of Oxford and Longview’s own founders; longtermist policy proposals from political philosophers, members of the House of Lords, and the All-party Parliamentary Group for Future Generations; the case for work on biosecurity, artificial intelligence, and climate change from leading experts; and the first ever essay on longtermist cultural change from the former Chief of Cabinet to the Finnish President. -/- Together, these essays chart the path forward toward maximising the good that we do for our grandchildren, our grandchildren’s grandchildren, and every generation beyond. (shrink)

This paper examines the proposition that adopting a socially responsible, or philanthropic, management posture is not antithetic to the capitalist business model but rather can be seen as a sound approach to the development of long-term sustainability in business in a modern business environment, wherein a strand of corporate social responsibility is one core aspect of the composite utility function of the modern business. We suggest further that for many of the prominent/significant examples of the successful adoption of a policy (...) of informed benevolence in the management of employees that policy seems to be faith rooted – be that faith Christian, Buddhist, Jewish, Muslim or other. Indeed, even if one observed an organisation subject to an humanist or even atheistic based socially responsible management, one could see that as being rooted in that organisation’s ‘non-faith’ faith, or ethical bubble. Our argument also gives the lie to the proposition, in currency in some circles, that the term ‘business ethics’ is an oxymoron. To underpin the argument we cite examples (/set out mini-cases, or a mixture of these) from a range of faith based traditions including, Buddhism, the Quaker-Christian tradition, Judaism and Islam. (shrink)

Political short-termism costs the global economy hundreds of billions to trillions of dollars annually, and leads to many millions of deaths from disasters and suboptimal spending. In this paper, I propose a futures assembly explicitly incentivised to promote the interests of future generations as a promising strategy to ameliorate short-termism. The assembly I propose is governed by citizens randomly selected from among the populace, who are rewarded in the future to the extent that they successfully promote the welfare of future (...) generations. The most initially promising such retrospective accountability mechanism is an iterated mechanism, in which each generation of policymakers rewards the previous generation for their policy choices and for their own evaluation of the previous generation. Such an assembly, supplemented with the duties, powers, and tools that I describe, and with appropriate support from archivists and experts, may manage to represent generations many years into the future. (shrink)

Although Ramachandra Guha has demonstrated the importance of cross-cultural dialogue on environmental issues and has much to tell us about the problems of wildemess preservation in the Third World, I argue that Guha is partly wrong in claiming that deep ecology equates environmental protection with wilderness protection and simply wrong in calling wilderness protection untenable or incorrect as aglobal strategy for environmental protection. Moreover, I argue that the deep ecology distinction between anthropocentrism and biocentrism is useful in dealing with the (...) two major problems which Guha identifies as undermining the health of the planetoverconsumption and militarism. Although it is true that preservation of wildemess will not be successful unless human social dynamics are taken into consideration, nevertheless, a biocentrism which integrates critical social theory can provide the basis for an ethic that undercuts the environmental degradation from overconsumption and militarism more effectively than a human-centered system. (shrink)

8 chapters are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

In his commentary on theTimaeus, the Neoplatonist Iamblichus argues that time is logically antecedent to change inasmuch as time is no mere aspect of change. Naturally, scholars appraise this thesis in light of Neoplatonic metaphysics. Nevertheless, they neglect the philological framing of this thesis, and thence the philosophical implications thereof. Only J.M. Dillon acknowledges this framing, though even Dillon does not acknowledge the philosophical implications thereof. This article illustrates the logic of said thesis vis-à-vis the Iamblichean exegesis ofTi. 38b7–c1 (Iambl.apudSimpl.in (...) Phys.1.794.21–7 Diels, Iambl.in Ti. fr. 67 Dillon). Beginning from the intuition that time is no mere aspect of change, Iamblichus argues that time can persist apart from change, and thereupon, given the Platonic notion that time is the everlasting image of Eternityquaparadigm, Iamblichus intuits that time is no mere image but everlasting in its own right, being itself a paradigm. Yet this thesis rests upon the indeterminateness of the Platonic titleτὸ παράδειγμα τῆς διαιωνίας φύσεως(‘the paradigm of a thoroughly everlasting nature’) atTi. 38b8 and, still more so, upon the reflexiveness of the ambiguousΑΥΤΩΙ(that is,αὐτῷ‘toit[the paradigm]’, if notαὑτῷ‘toitself[as paradigm]’) atTi. 38c1. Inasmuch as the subject of the Platonic title is indeterminate between Eternity and Eternal Beingquaintelligible everlastingness, Iamblichus construesΑΥΤΩΙnot as a mere reflexive but as self-reflexive, withαὑτῷreferring to Timequaintelligible paradigm. In this light, the Platonic lemma grounds the Iamblichean thesis. (shrink)

Adversities in pregnancy, including poor diet and stress, are associated with increased risk of developing both metabolic and mental health disorders later in life, a phenomenon described as fetal programming or developmental origins of disease. Predominant hypotheses proposed to explain this relationship suggest that the adversity imposes direct changes to the developing fetus which are maintained after birth resulting in an increased susceptibility to ill health. However, during pregnancy the mother, the developing fetus, and the placenta are all exposed to (...) the adversity. The same adversities linked to altered offspring outcome can also result in suboptimal maternal care, which is considered an independent adverse exposure for the offspring. Recent key experiments in mice reveal the potential of prenatal adversity to drive alterations in maternal care through abnormal maternal–pup interactions and via alterations in placental signaling. Together, these data highlight the critical importance of viewing fetal programming holistically paying attention to the intimate, bidirectional, and reiterative relationship between mothers and their offspring. (shrink)

Although Ramachandra Guha has demonstrated the importance of cross-cultural dialogue on environmental issues and has much to tell us about the problems of wildemess preservation in the Third World, I argue that Guha is partly wrong in claiming that deep ecology equates environmental protection with wilderness protection and simply wrong in calling wilderness protection untenable or incorrect as aglobal strategy for environmental protection. Moreover, I argue that the deep ecology distinction between anthropocentrism and biocentrism is useful in dealing with the (...) two major problems which Guha identifies as undermining the health of the planetoverconsumption and militarism. Although it is true that preservation of wildemess will not be successful unless human social dynamics are taken into consideration, nevertheless, a biocentrism which integrates critical social theory can provide the basis for an ethic that undercuts the environmental degradation from overconsumption and militarism more effectively than a human-centered system. (shrink)

This article reports the findings of a cross-cultural study that explored the relationship between nationality, cultural orientation, and attitudes toward different ways in which an employee might blow the whistle. The study investigated two questions – are there any significant differences in the attitudes of university students from South Korea, Turkey and the U.K. toward various ways by which an employee blows the whistle in an organization?, and what effect, if any, does cultural orientation have on these attitudes? In order (...) to answer these questions, the study identified six dimensions of whistleblowing and four types of cultural orientation. The survey was conducted among 759 university students, who voluntarily participated; 284 South Korean, 230 Turkish, and 245 U.K. Although all three samples showed a preference for formal, anonymous and internal modes of whistleblowing, there were significant variations related to nationality and cultural orientation. The findings have some key implications for organizational practice and offer directions for future research. (shrink)

The predictions by the Department of Energy indicate the maximum of the rate of supply of oil will be reached around 2021, but this neglects the effect of the rapid growth of China and India. It will be necessary to use coal, natural gas, nuclear power, or renewables to supplement, and, after 2021, to replace oil. If coal is used, it can be reacted with steam to produce H2, the burning of which produces only water. If nuclear power is developed, (...) the 30% of nuclear energy at present wasted can be used to produce H2. Renewables are sporadic and need hydrogen as a storage means and for transmission. (shrink)

Two major twentieth century philosophers, of East and West, for whom the nothing is a significant concept are Nishida Kitarō and Martin Heidegger. Nishida’s basic concept is the absolute nothing upon which the being of all is predicated. Heidegger, on the other hand, thematizes the nothing as the ulterior aspect of being. Both are responding to Western metaphysics that tends to substantialize being and dichotomize the real. Ironically, however, while Nishida regarded Heidegger as still trapped within the confines of Western (...) metaphysics with its tendency to objectify, Heidegger’s impression of Nishida was that he is too Western, that is, metaphysical. Yet neither was too familiar with the other’s philosophical work as a whole. I thus compare and assess Nishida’s and Heidegger’s discussions of the nothing in their attempts to undermine traditional metaphysics while examining lingering assumptions about the Nishida–Heidegger relationship. Neither Nishida nor Heidegger means by “nothing” a literal nothing, but rather that which permits beings in their relative determinacy to be what they are and wherein or whereby we find ourselves always already in our comportment to beings. Nishida characterizes this as a place that negates itself to give rise to, or make room for, beings. For Heidegger, being as an event that clears room for beings, releasing each into its own, is not a being, hence nothing. We may also contrast them on the basis of the language they employ in discussing the nothing. Yet each seemed to have had an intuitive grasp of an un/ground, foundational to experience and being. And in fact their paths cross in their respective critiques of Western substantialism, where they offer as an alterantive to that substantialist ontology, in different ways, what I call anontology. (shrink)

In this paper, I explore a possible convergence between two great twentieth century thinkers, Nishida Kitarō of Japan and Martin Heidegger of Germany. The focus is on the quasi-religious language they employ in discussing the grounding of human existence in terms of an encompassing Wherein for our being. Heidegger speaks of “the sacred” and “the passing of the last god” that mark an empty clearing wherein all metaphysical absolutes or gods have withdrawn but are simultaneously indicative of an opening wherein (...) beings are given. Nishida speaks of “the religious” dimension in the depths of one's being, that he calls “place,” and that somehow envelops the world through its kenotic self-negation. In both we find reference to a kind of originary space—the open or place—associated with quasireligious themes. I also point to their distinct approaches to metaphysical language in their attempts to give voice to that abysmal thought. (shrink)