Phosphatidylinositol 5‐phosphate (PtdIns5P), the least characterized among the three phosphatidylinositol monophosphates, is emerging as a bioactive lipid involved in the control of several cellular functions. Similar to PtdIns3P, it is present in low amounts in mammalian cells, and can be detected at the plasma membrane and endomembranes as well as in the nucleus. Changes in PtdIns5P levels are observed in mammalian cells following specific stimuli or stresses, and in human diseases. Recently, the contribution of several enzymes such as PIKfyve, myotubularins, (...) and type II PtdInsP‐kinases to PtdIns5P metabolism has gained a strong experimental support. Here, we provide a picture emerging from recent studies showing how this lipid can be generated and act as a regulator of membrane and cytoskeleton dynamics, and as a modulator of gene expression. We briefly summarize the current methods and tools for studying PtdIns5P, and discuss how PtdIns5P can integrate and coordinate different functions in a spatiotemporal manner. (shrink)

Dans le Continu, Hermann Weyl donne une nouvelle assise aux notions d’ensemble et de fonction, pour assurer aux mathématiques leur applicabilité à la physique, et résoudre ainsi le problème du continu. Les notions introduites, éloignées de la théorie des ensembles, prêtent à confusion et à multiples interprétations.Nous nous proposons d’éclairer le sens du déplacement que Weyl opère dans ces notions. Nous présentons une synthèse des thèses épistémologiques soutenues dans Le Continu et résolvons certains problèmes interprétatifs. Par une approche comparative, nous (...) soulignons l’écart entre les principes logico-mathématiques du Continu et ceux de la théorie des ensembles. Nous nous centrons sur la distinction entre intension et extension, et sur la place attribuée aux entiers naturels pour le fondement des mathématiques. (shrink)

Dans le Continu, Hermann Weyl donne une nouvelle assise aux notions d’ensemble et de fonction, pour assurer aux mathématiques leur applicabilité à la physique, et résoudre ainsi le problème du continu. Les notions introduites, éloignées de la théorie des ensembles, prêtent à confusion et à multiples interprétations.Nous nous proposons d’éclairer le sens du déplacement que Weyl opère dans ces notions. Nous présentons une synthèse des thèses épistémologiques soutenues dans Le Continu et résolvons certains problèmes interprétatifs. Par une approche comparative, nous (...) soulignons l’écart entre les principes logico-mathématiques du Continu et ceux de la théorie des ensembles. Nous nous centrons sur la distinction entre intension et extension, et sur la place attribuée aux entiers naturels pour le fondement des mathématiques. (shrink)

This book investigates Hermann Weyl’s work on the problem of space from the early 1920s onwards. It presents new material and opens the philosophical problem of space anew, crossing the disciplines of mathematics, history of science and philosophy. With a Kantian starting point Weyl asks: among all the infinitely many conceivable metrical spaces, which one applies to the physical world? In agreement with general relativity, Weyl acknowledges that the metric can quantitatively vary with the physical situation. Despite this freedom, Weyl (...) “deduces”, with group-theoretical technicalities, that there is only one “kind” of legitimate metric. This construction was then decisive for the development of gauge theories. Nevertheless, the question of the foundations of the metric of physical theories is only a piece of a wider epistemological problem. Contributing authors mark out the double trajectory that goes through Weyl’s texts, from natural science to philosophy and conversely, always through the mediation of mathematics. Readers may trace the philosophical tradition to which Weyl refers and by which he is inspired, and explore the mathematical tradition that permitted Weyl to elaborate and solve his mathematical problem of space. Furthermore, this volume analyzes the role of the interlocutors with whom Weyl discussed the nature of physical space. This volume features the work of top specialists and will appeal to postgraduates and scholars in philosophy, the history of science, mathematics, or physics. (shrink)

This article is devoted to the analysis of the remarks of Gödel's Maxims and Philosophical remarks (Max Phil) that present a solution to the paradoxes of set theory, and to the analysis of the context. It is divided in two parts. The first part contains two remarks from the notebook IX, (pp. 48b, 51) on the question of the strategies for the solution of paradoxes. They clearly show Gödel’s preference for the strategy of limited ranges of significance. The reasons why (...) Gödel was also interested in the other strategies suggested by Russell is explained through two remarks of Max Phil IX (pp.69 and 72b) The second part presents a remark from Max Phil X (p. 28-29), and explains it from the perspective of Gödel analysis of concepts in the early 1943. (shrink)

A leading critic of the disruptive force of technology in education, Bernard Stiegler saw the counter-effects of artificial intelligence in undermining human agency, autonomy and individuality, rendering the role of education ever more critical. Stiegler believes that our goal is not to abandon technology but to focus our attention on its power and direction in a hypercapitalist economy. While he did not foresee the emergence of generative artificial intelligence (GAI), its rapid acceleration raises important issues for his notion of (...) digital writing as a pharmakon. In this essay, we examine Stiegler’s view on intelligence, digital writing, technological memory, and neuropower, focusing specifically on his Shanghai lecture and Nanjing Lectures. We compare Stiegler with Catherine Malabou, who examines the nature of intelligence primarily through the lens of neuroscience. We argue that Malabou’s view of neuroplasticity in human and artificial brains, and her critique of techno-narcissism in the control over technology, add an important dimension to Stiegler’s political critique of education. Finally, we examine how best to construe AI as part of a hyper-materialist epistemology that Stiegler espouses in the conclusion of his Nanjing Lectures, to bring about neganthropic knowledge through a therapeutics of care. (shrink)

"Repartir d'une lecture à nouveaux frais de la Métaphysique d'Aristote en essayant de prêter l'oreille à la manière dont elle parle en grec, tel est le projet de ce livre. Cela veut dire d'abord oublier ce qui nous a été transmis si longtemps dans le latin de la scolastique médiévale. C'est se donner la chance de rencontrer une pensée à même la langue. On comprend alors que le mot eidos ne peut pas se traduire par "idée" : il désigne avant (...) tout le "visage" que quelque chose ou quelqu'un tourne vers nous, de même le mot theoria renvoie, lui aussi, à la vue d'un spectacle qui s'offre à nous. Si les fameuses "catégories" d'Aristote sont dépendantes des structures de la langue grecque, ce n'est pas une limite : c'est une chance dont Aristote se saisit pour avancer dans la pensée de l'être. Ce parcours au plus près de la langue ne se réduit pas à un monologue au sein de la seule parole occidentale mais s'ouvre à une confrontation entre la Grèce et la Chine sur les pas de François Julien : comment entendre sans conflictualité un tel vis-à-vis entre une pensée non métaphysique du Grand Procès (Tao) ou de la "propension des choses", et une histoire de la métaphysique dont Aristote est une prestigieuse entame et dont le philosophe sinologue voudrait nous délivrer?"--Page 4 of cover. (shrink)

By the time of his death in 2003, Bernard Williams was one of the greatest philosophers of his generation. Ethics and the Limits of Philosophy is not only widely acknowledged to be his most important book, but also hailed a contemporary classic of moral philosophy. Presenting a sustained critique of moral theory from Kant onwards, Williams reorients ethical theory towards ‘truth, truthfulness and the meaning of an individual life’. He explores and reflects upon the most difficult problems in contemporary (...) philosophy and identifies new ideas about central issues such as relativism, objectivity and the possibility of ethical knowledge. This edition also includes a new commentary on the text by A.W.Moore and a foreword by Jonathan Lear. (shrink)

This edition includes, in addition to the most pertinent sections of The Fable's two volumes, a selection from Mandeville's An Enquiry into the Origin of Honor and selections from two of Mandeville's most important sources: Pierre Bayle and the Jansenist Pierre Nicole. Hundert's Introduction places Mandeville in a number of eighteenth-century debates--particularly that of the nature and morality of commercial modernity--and underscores the degree to which his work stood as a central problem, not only for his immediate English contemporaries, but (...) for such philosophers as Hume, Rousseau, and Kant. The selections are substantive enough to faithfully represent Mandeville the social theorist, and compact enough to be used in courses that can afford to spend no more than a week on his work. (shrink)

By the time of his death in 2003, Bernard Williams was one of the greatest philosophers of his generation. Ethics and the Limits of Philosophy is not only widely acknowledged to be his most important book, but also hailed a contemporary classic of moral philosophy. Presenting a sustained critique of moral theory from Kant onwards, Williams reorients ethical theory towards ‘truth, truthfulness and the meaning of an individual life’. He explores and reflects upon the most difficult problems in contemporary (...) philosophy and identifies new ideas about central issues such as relativism, objectivity and the possibility of ethical knowledge. (shrink)

With a new foreword by Jonathan Lear 'Remarkably lively and enjoyable…It is a very rich book, containing excellent descriptions of a variety of moral theories, and innumerable and often witty observations on topics encountered on the way.' -_ Times Literary Supplement_ Bernard Williams was one of the greatest philosophers of his generation. Ethics and the Limits of Philosophy is not only widely acknowledged to be his most important book, but also hailed a contemporary classic of moral philosophy. Drawing on (...) the ideas of the Greek philosophers, Williams reorients ethics away from a preoccupation with universal moral theories towards ‘truth, truthfulness and the meaning of an individual life’. He explores and reflects upon the most difficult problems in contemporary philosophy and identifies new ideas about central issues such as relativism, objectivity and the possibility of ethical knowledge. This edition also includes a commentary on the text by A.W.Moore. At the time of his death in 2003, Bernard Williams was hailed by the Times as 'the outstanding moral philosopher of his age.' He taught at the Universities of Cambridge, Berkeley and Oxford and is the author of many influential books, including _Morality; Descartes: The Project of Pure Enquiry_ and _Truth and Truthfulness_. (shrink)

Simone Weil (1909-1943), philosophe reconnue, engagée, mystique, ne laisse personne indifférent. Son année d'enseignement à Bourges (octobre 1935-juin 1936) est une année charnière, un moment de répit dans une courte vie mouvementée. Elle y réfléchit et y médite. Professeur de philosophie, elle a laissé une forte impression sur ses jeunes élèves du lycée de jeunes filles de Bourges. Ce sont ses cours, retrouvés grâce à deux anciennes élèves, que vous lirez dans cet ouvrage.

Le polythéisme polynésien était-il une forme métaphorique de panthéisme ?

How I became a philosopher -- To love, to love me, to love us.

In the mid twentieth century the philosopher Ludwig Wittgenstein famously asserted that games are indefinable; there are no common threads that link them all. "Nonsense," says the sensible Bernard Suits: "playing a game is a voluntary attempt to overcome unnecessary obstacles." The short book Suits wrote demonstrating precisely that is as playful as it is insightful, as stimulating as it is delightful. Suits not only argues that games can be meaningfully defined; he also suggests that playing games is a (...) central part of the ideal of human existence, so games belong at the heart of any vision of Utopia. Originally published in 1978, The Grasshopper is now re-issued with a new introduction by Thomas Hurka and with additional material (much of it previously unpublished) by the author, in which he expands on the ideas put forward in The Grasshopper and answers some questions that have been raised by critics. (shrink)

We tend to suppose that the ancient Greeks had primitive ideas of the self, of responsibility, freedom, and shame, and that now humanity has advanced from these to a more refined moral consciousness. Bernard Williams's original and radical book questions this picture of Western history. While we are in many ways different from the Greeks, Williams claims that the differences are not to be traced to a shift in these basic conceptions of ethical life. We are more like the (...) ancients than we are prepared to acknowledge, and only when this is understood can we properly grasp our most important differences from them, such as our rejection of slavery. The author is a philosopher, but much of his book is directed to writers such as Homer and the tragedians, whom he discusses as poets and not just as materials for philosophy. At the center of his study is the question of how we can understand Greek tragedy at all, when its world is so far from ours. Williams explains how it is that when the ancients speak, they do not merely tell us about themselves, but about ourselves. _Shame and Necessity_ gives a new account of our relations to the Greeks, and helps us to see what ethical ideas we need in order to live in the modern world. (shrink)

This article explores the differences and intellectual affinities between Jacques Ellul and René Girard on the question of violence in today’s world. In this respect, both thinkers share the conviction that violence has changed form because of material and spiritual factors. The presentation of these factors will enable us to show the differences, but above all the complementarities, between Girard and Ellul. Finally, based on these two authors, the article sketches out an attempt to describe the future of violence.

Bernard Williams's remarkable essay on morality confronts the problems of writing moral philosophy, and offers a stimulating alternative to more systematic accounts which seem nevertheless to have left all the important issues somewhere off the page. Williams explains, analyses and distinguishes a number of key positions, from the purely amoral to notions of subjective or relative morality, testing their coherence before going on to explore the nature of 'goodness' in relation to responsibilities and choice, roles, standards, and human nature. (...) The final chapters make a fascinating enquiry into what morality is about, looking beyond happiness to other human aims and ideals. This re-issue of a classic in moral philosophy includes a new foreword by the author. (shrink)

It is well known in contemporary Madhyamaka studies that the seventh century Indian philosopher Candrakīrti rejects the foundationalist Abhidharma epistemology. The question that is still open to debate is: Does Candrakīrti offer any alternative Madhyamaka epistemology? One possible way of addressing this question is to find out what Candrakīrti says about the nature of buddha’s epistemic processes. We know that Candrakīrti has made some puzzling remarks on that score. On the one hand, he claims buddha is the pramāṇabhūta-puruṣa (person of (...) epistemic and moral authority), sarvākārajñatājñānaṃ (omniscient, wise), pratyakṣalakṣaṇam (exclusively perceptual in characteristic) [Candrakīrti (MABh VI.214)], and claims that there are clearly four pramāṇas—epistemic warrants—direct perception (pratyakṣa), inference (anumāna), testimony (āgama) and analogy (upamāna) [Candrakīrti (Pp I.3), cf. MacDonald 2015, pp. 287–288]. On the other hand, somewhat paradoxically, Candrakīrti claims that buddhahood is an embodiment of a complete cessation of “mind and mental processes” [Candrakīrti (MABh XI.1, 155a; MAB XI.17d)] Now how are we to make sense of these two seemingly contradictory statements? Do these statements reflect any deeper conflicts within Candrakīrti’s system or is there a coherent way to interpret these statements? The Tibetan Prāsaṅgika interpreters of Candrakīrti’s Madhyamaka largely agree that there is no internal contradiction in Candrakīrti’s system, and agree there is a way to make coherent sense of these statements. Nevertheless, the Tibetans exegetes bring to the table two radically conflicting proposals to approach Candrakīrti’s Mādhyamaka; both claiming to successfully address the apparent tension arising from Candrakīrti’s statements. One proposal is made by Tsongkhapa Losang Dakpa (Tsong kha pa bLo bzang grags pa, 1357–1419), who maintains the tension can be plausibly resolved by demonstrating that Candrakīrti’s unique non-foundationalist epistemological program renders him an epistemological coherentist. In contrast Taktsang Lotsawa Sherap Rinchen (sTag tshang Lo tsā ba Shes rab rin chen, 1405–1477) argues that according to Candrakīrti buddha is a global agnostic, on the ground of the nonexistence of mind and mental processes for those who have attained fully awakening. Taktsang instead proposes the no-mind thesis as a more plausible way to resolve the tension in Candrakīrti’s philosophy, categorically refusing to attribute to buddha any cognitive processes and epistemic warrants. This paper is an analysis of Taktsang’s no-mind thesis—the claim that buddhas utterly lack any knowledge of the world because they do not have epistemic processes and warrants to perceive the world—in what follows a rational reconstruction of his arguments is developed in order to evaluate his thesis. We shall then assess the implications of accepting Taktsang’s no-mind thesis. (shrink)

One puzzle concerning highly idealized models is whether they explain. Some suggest they provide so-called ‘how-possibly explanations’. However, this raises an important question about the nature of how-possibly explanations, namely what distinguishes them from ‘normal’, or how-actually, explanations? I provide an account of how-possibly explanations that clarifies their nature in the context of solving the puzzle of model-based explanation. I argue that the modal notions of actuality and possibility provide the relevant dividing lines between how-possibly and how-actually explanations. Whereas how-possibly (...) explanations establish claims of possible explanations, how-actually explanations establish claims of actual ones. Models, in turn, simply provide evidence for these claims. (shrink)

We shall see that as the Master of suspicion, Marx rejects capitalism, which he considers to be a system of bourgeois oppression, absurd and decadent. The latter eludes the importance of the social question in the historical future of a society. Trampling on the lyrical illusions of practical rationality, he insists on the rigidity of economic and social determinisms, to which he confers an overdeterminent role in sub-estimating the impact of cognitive and/or psychological mechanisms on the exercise of state power. (...) We will explain how dialectical materialism in Marx joins in many respects the methodological revolution initiated by Nietzsche, particularly as regards its requirement to contextualize a real understood as a fabric of forces, in order to understand the origin of the dominant values and that of the capitalist system. Moreover, it will be important to develop the idea that within a civil society, itself prey to a crisis of the sittlichkeit (the ethical life), history tends to separate the interests in favor of imperceptible cowards perverse become legion, while insidiously affecting a social body incapable of escaping from material contingencies. We will then have the right to question the way in which revolutions occur? (shrink)

There is a traditional conception of knowledge but it is not the Justified True Belief analysis Gettier attacked. On the traditional view, knowledge consists in having a belief that bears a discernible mark of truth. A mark of truth is a truth-entailing property: a property that only true beliefs can have. It is discernible if one can always tell that a belief has it, that is, a sufficiently attentive subject believes that a belief has it if and only if it (...) has it. Requiring a mark of truth makes the view infallibilist. Requiring it to be discernible makes the view internalist. I call the view Classical Infallibilism. (shrink)

Bernard Williams is remembered as one of the most brilliant and original philosophers of the past fifty years. Widely respected as a moral philosopher, Williams began to write about politics in a sustained way in the early 1980s. There followed a stream of articles, lectures, and other major contributions to issues of public concern--all complemented by his many works on ethics, which have important implications for political theory. This new collection of essays, most of them previously unpublished, addresses many (...) of the core subjects of political philosophy: justice, liberty, and equality; the nature and meaning of liberalism; toleration; power and the fear of power; democracy; and the nature of political philosophy itself. A central theme throughout is that political philosophers need to engage more directly with the realities of political life, not simply with the theories of other philosophers. Williams makes this argument in part through a searching examination of where political thinking should originate, to whom it might be addressed, and what it should deliver. Williams had intended to weave these essays into a connected narrative on political philosophy with reflections on his own experience of postwar politics. Sadly he did not live to complete it, but this book brings together many of its components. Geoffrey Hawthorn has arranged the material to resemble as closely as possible Williams's original design and vision. He has provided both an introduction to Williams's political philosophy and a bibliography of his formal and informal writings on politics. Those who know the work of Bernard Williams will find here the familiar hallmarks of his writing--originality, clarity, erudition, and wit. Those who are unfamiliar with, or unconvinced by, a philosophical approach to politics, will find this an engaging introduction. Both will encounter a thoroughly original voice in modern political theory and a searching approach to the shape and direction of liberal political thought in the past thirty-five years. (shrink)

This new volume of philosophical papers by Bernard Williams is divided into three sections: the first Action, Freedom, Responsibility, the second Philosophy, Evolution and the Human Sciences; in which appears the essay which gives the collection its title; and the third Ethics, which contains essays closely related to his 1983 book Ethics and the Limits of Philosophy. Like the two earlier volumes of Williams's papers published by Cambridge University Press, Problems of the Self and Moral Luck, this volume will (...) be welcomed by all readers with a serious interest in philosophy. It is published alongside a volume of essays on Williams's work, World, Mind, and Ethics: Essays on the Ethical Philosophy of Bernard Williams, edited by J. E. J. Altham and Ross Harrison, which provides a reappraisal of his work by other distinguished thinkers in the field. (shrink)

Bernard Williams; XIV*—The Truth in Relativism, Proceedings of the Aristotelian Society, Volume 75, Issue 1, 1 June 1975, Pages 215–228, https://doi.org/10.1093.

The emotions are at the centre of our lives and, for better or worse, imbue them with much of their significance. The philosophical problems stirred up by the existence of the emotions, over which many great philosophers of the past have laboured, revolve around attempts to understand what this significance amounts to. Are emotions feelings, thoughts, or experiences? If they are experiences, what are they experiences of? Are emotions rational? In what sense do emotions give meaning to what surrounds us? (...) -/- The Emotions: A Philosophical Introduction introduces and explores these questions in a clear and accessible way. The authors discuss the following key topics: -/- the diversity and unity of the emotions the relations between emotion, belief and desire the nature of values the relations between emotions and perceptions emotions viewed as evaluative attitudes the link between emotions and evaluative knowledge the nature of moods, sentiments, and character traits. -/- Including chapter summaries and guides to further reading, The Emotions: A Philosophical Introduction is an ideal starting point for any philosopher or student studying the emotions. It will also be of interest to those in related disciplines such as psychology and the social sciences. (shrink)

When spelled out properly infallibilism is a viable and even attractive view. Because it has long been summary dismissed, however, we need a guide on how to properly spell it out. The guide has to fulfil four tasks. The first two concern the nature of knowledge: to argue that infallible belief is necessary, and that it is sufficient, for knowledge. The other two concern the norm of belief: to argue that knowledge is necessary, and that it is sufficient, for justified (...) certainty. With such a guide in hand infallibilism can be evaluated on its own merits. The most controversial parts are the first and fourth. The idea that knowledge requires infallible belief is thought to be excessively sceptical. The idea that knowledge warrants certainty is thought to be excessively dogmatic. The present paper addresses the first. It argues that knowledge requires infallible belief. (shrink)

For Hannah Arendt, authority is the shape educational responsibility assumes. In our time, authority in Arendt’s sense is under pressure. The figure of Greta Thunberg shows the failure of adult generations, taken collectively, to take responsibility for the world and present and future generations of newcomers. However, in reflecting on Arendt’s use of authority, we argue that her account of authority also requires amendments. Arendt’s situating of educational authority in-between past and future adequately captures its temporal dimension. We make explicit (...) another, spatial, dimension: authority in-between world and earth. Arendt’s neglect of the material earth also has implications for the relational dimension of authority. Arendt’s authority depends on a dichotomy between the private and the public sphere. This is problematic. First, we agree with Arendt’s feminist critics that the personal can be made into the site of the political. Second, we point once more to Thunberg, the child, taking the public stage, thereby contesting the division between public and private. In response, we situate the relational dimension of authority in-between private and public. The three dimensions of educational authority taken together imply that it is situated in-between domains that cannot be reduced to each other or taken as absolutes: past and future, world and earth, and the private and public sphere. This brings us to our concept of ambiguous authority, which expresses the Arendtian nature of our reflections and the ways in which we seek to renew her original insights on educational authority. (shrink)

Argumentation has been an important topic in knowledge representation, reasoning and multi-agent systems during the last twenty years. In this paper, we propose a new abstract framework where arguments are associated with a strength, namely a quantitative information which is used to determine whether an attack between arguments succeeds or not. Our Strength-based Argumentation Framework combines ideas of Preference-based and Weighted Argumentation Frameworks in an original way, which permits to define acceptability semantics sensitive to the existence of accruals between arguments. (...) The question of accruals arises in situations where several arguments defending the same position against another argument are unable to individually defeat this argument, but could do it collectively if they combine their strengths. We investigate some of the theoretical and computational properties of our new framework and semantics, and present a reasoning algorithm that is based on a translation of the problem into pseudo-boolean constraint satisfaction. This paper proposes an intuitive framework which allows strength compensations in an argumentation context where attacks may not succeed, completed by an approach which detects accruals throughout the reasoning process without requiring the elicitation of all compensatory combinations of arguments as an input. (shrink)