Pease ad loc.: ‘Roman writers often use axis… in a figurative sense… for the caelum as a whole, and in our passage, while the force is applied by Atlas to the axis of the sphere, yet the whole sphere is apparently in mind, as the phrase stellis ardentibus aptum indicates.’ It is lexicographical commonplace that axis is used, especially in the poets, as a synonym for the sky, yet the oddity of the synecdoche by which a scientific, or pseudoscientific, term (...) for the axis of the universe is transferred to mean the heavens in general has been little commented on; unanalytic recognition of the semantic fact is the norm . I believe that a more precise account of this transference can be given, and in particular I will argue that Virgilian usage in the Aeneid is central to the history of this process. (shrink)

In his discussion of Virgilian imitations of Lucretian phraseology Cyril Bailey examines the phenomenon of what he terms the ‘doublet’, that is, the procedure whereby Virgil imitates separate elements of a Lucretian phrase at different points in his own work. Take, for example, De Rerum Natura 1. 210–12: esse videlicet in terris primordia rerum, quae nos fecundas vertentes vomere glebas terraique solum subigentes cimus ad ortus.

Avoiding whinges from various and potentially conflicting stakeholders is a major challenge for sustainable development and for the identification of sustainability scenarios or policies for biodiversity and ecosystem services. It turns out that independently complying with whinge thresholds and constraints of these stakeholders is not sufficient because dynamic ecological-economic interactions and uncertainties occur. Thus more demanding no whinge standards are needed. In this paper, we first argue that these new boundaries can be endogenously exhibited with the mathematical concepts of viability (...) kernel and viable controls. Second, it is shown how these no whinge kernels have components, such as harvesting of resources, that should remain within safe corridor while some other components, in particular biodiversity, have only lower conservation limits. Thus, using radar charts, we show how this no whinge kernels can take the shape of a tree that we name viability tree. These trees of viability capture the idea that the unbounded renewal potential of biodiversity combined with a bounded use of the different ecosystem services are crucial ingredients for the sustainability of socio-ecosystems and the design of no whinge policies reconciling the different stakeholders involved. (shrink)

Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

Revision of the author's thesis, University of Wisconsin, 1970. Bibliography: p. 155-158.

There are important studies that have directly focused on how, in times of conflict, it is possible for previously law abiding people to commit the most atrocious acts of cruelty and violence. The work of Erich Fromm, Hannah Arendt, Zygmunt Bauman and Ernest Becker have all contemplated the driving force of aggression and mass violence to further our understanding of how people are capable of engaging in extreme forms of cruelty and violence. This paper specifically addresses these issues by focusing (...) on C. P. Taylor’s play Good. This provocative play examines how a seemingly ‘good’ and intelligent university professor can gradually become caught up in the workings of the Third Reich. Taylor highlights the importance of appreciating how people can be steadily incorporated into an ideologically destructive system. I argue that the theatre is a powerful medium to explore these complex issues. The audience of Good find themselves confronted with the following question—‘What would you have done?’. (shrink)

Although existentialism and evolutionary biology might appear to be polar opposites, with the former denying a role for “human nature” and the latter emphasizing it, there are some unrecognized parallels. One in particular is that both disciplines assume that human life is not inherently meaningful, such that any attribution of meaning must arise from human actions. The present article traces some of this intellectual correspondence in the realm of literature.

Fergus Kelly: Thinking in Threes: The Triad in Early Irish Literature Brian Pullan: Charity and Usury: Jewish and Christian Lending in Renaissance and Early Modern Italy Noel Malcolm: The Crescent and the City of the Sun: Islam and the Renaissance Utopia of Tommaso Campanella H. R. Woudhuysen: The Foundations of Shakespeare's Text J. G. A. Pocock: The Re-Description of Enlightenment Andrew Hadfield: Michael Drayton and the Burden of History Eric Foner: Abraham Lincoln: The Great Emancipator? Gillian Beer: Revenants and Migrants: (...) Hardy, Butler, Woolf and Sebald Stephen Banfield: Scholarship and the Musical: Reclaiming Jerome Kern Brian Simpson: The Rule of Law in International Affairs Christopher Bayly: 'The Nation Within': British India at War 1939-47 John Vickers: Economics for Consumer Policy Gillian Feeley-Harnik: The Geography of Descent Susan Gathercole: Working Memory and Learning During the School Years Lothar Ledderose: Carving Stone Sutras before the World Ends: The Inscription of 1118 CE at Cloud Dwelling Monastery near Beijing. (shrink)

Following the lead of Kant more fully than the master himself, Muyskens defends the thesis that so-called "religious beliefs," or at least fundamental ones like the beliefs in the existence of God and life after death, should be construed more on the model of hope than on the model of belief, as we find the latter in more mundane contexts. He is not so hardy as to claim that religious believers generally hold their beliefs as hopes. On the contrary, he (...) recognizes that in much of the Christian tradition there is a stress on certainty and confidence that God exists and that our life will continue beyond the grave, and on the cosmic security provided by Christian faith. Muyskens's position is that religious belief can be justifiably held only if it takes something like the form of hope. To undergird this position he provides an analysis of hope as a propositional attitude, hoping that p, with some glances at treatments of hope by Aquinas, Descartes, Hobbes, Hume, and Gabriel Marcel. S hopes that p if and only if: S desires that p; It is not the case that p is not preferred by S on balance, or that S believes that q, which he prefers on balance, is incompatible with p; Neither p nor not-p is certain for S; S is disposed to act as if p. (shrink)

In this paper, the structure of a southeastern Spanish population was studied for the first time with respect to its inbreeding patterns and its relationship with demographic and geographic factors. Data on consanguineous marriages from 1900 to 1969 were taken from ecclesiastic dispensations. Our results confirm that the patterns and trends of inbreeding in the study area are consistent with those previously observed in most non-Cantabrian Spanish populations. The rate of consanguineous marriages was apparently stable between 1900 and 1935 and (...) then sharply decreased since 1940, which coincides with industrialization in Spain. A marked departure from Hardy-Weinberg expectations in the ratio of first cousin to second cousin marriages in the study population was observed. The high levels of endogamy and its significant steadiness throughout the twentieth century is noteworthy. Accordingly, our results show that exogamous marriages were not only poorly represented but also that this reduced mobility suggests that the choice of a mate was preferentially local. We found higher mobility in M22 with respect to M33 cousin mating. The relationships between population size and consanguinity rates and inbreeding fit power-law distributions. A significant positive correlation was observed between inbreeding and elevation. Many Spanish populations have experienced a prolonged and considerable isolation across generations, which has led to high proportions of historical and local endogamy that is associated, in general, with high \ values. Thus, assessing genomic inbreeding using runs of homozygosity in current Spanish populations could be an additional pertinent strategy for obtaining a more refined perspective regarding the population history inferred from the extent and frequency of ROH regions. (shrink)