As Dobzhansky wrote, nothing in biology makes sense outside the context of the evolutionary theory, and this truth has not been sufficiently explored yet by medicine. We comment on Shanks and Pyles' recently published paper, Evolution and medicine: the long reach of "Dr. Darwin", and discuss some recent advancements in the application of evolutionary theory to carcinogenesis. However, we disagree with Shanks and Pyles about the usefulness of animal experiments in predicting human hazards. Based on the darwinian observation of inter-species (...) and inter-individual variation in all biological functions, Shanks and Pyles suggest that animal experiments cannot be used to identify hazards to human health. We claim that while the activity of enzymes may vary among individuals and among species, this does not indicate that critical events in disease processes occurring after exposure to hazardous agents differ qualitatively between animal models and humans. In addition, the goal is to avoid human disease whenever possible and with the means that are available at a given point in time. Epidemics of cancer could have been prevented if experimental data had been used to reduce human exposures or ban carcinogenic chemicals. We discuss examples. (shrink)

In the last decades, Systems Biology (including cancer research) has been driven by technology, statistical modelling and bioinformatics. In this paper we try to bring biological and philosophical thinking back. We thus aim at making diferent traditions of thought compatible: (a) causality in epidemiology and in philosophical theorizing—notably, the “sufcient-component-cause framework” and the “mark transmission” approach; (b) new acquisitions about disease pathogenesis, e.g. the “branched model” in cancer, and the role of biomarkers in this process; (c) the burgeoning of omics (...) research, with a large number of “signals” and of associations that need to be interpreted. In the paper we summarize frst the current views on carcinogenesis, and then explore the relevance of current philosophical interpretations of “cancer causes”. We try to ofer a unifying framework to incorporate biomarkers and omic data into causal models, referring to a position called “evidential pluralism”. According to this view, causal reasoning is based on both “evidence of diference-making” (e.g. associations) and on “evidence of underlying biological mechanisms”. We conceptualize the way scientists detect and trace signals in terms of information transmission, which is a generalization of the mark transmission theory developed by philosopher Wesley Salmon. Our approach is capable of helping us conceptualize how heterogeneous factors such as micro and macro-biological and psycho-social—are causally linked. This is important not only to understand cancer etiology, but also to design public health policies that target the right causal factors at the macro-level. (shrink)

In this paper we set out to examine thearguments for and against the claim thatEvidence-Based Medicine (EBM) will improve thequality of care. In particular, we examine thefollowing issues.

Since the microbiological revolution, most infectious diseases have been defined and classified according to an etiologic criterion, i.e. the identification of single, external necessary causes (for example, Mycobacterium for tuberculosis). This is not the case with cancer. Not only external necessary causes of cancer have not been identified, but also the morphological classification cannot be based on univocal criteria. Although neoplasia and anaplasia appear to be universal attributes of cancer, these events are only quantitative. Neoplastic growth can be fast or (...) slow (development may take weeks or years), and tissue pathologies are difficult to detect from normal tissue in some cancers but are obvious in others. Common special properties of anaplasia appear to be concealed in the wide range of morphologies. In the absence of a coherent morphological definition, and of external necessary causes (such as bacteria for infectious diseases), a mechanistic definition could be adopted. However, unless molecular biology discovers specific mechanistic steps in carcinogenesis, which indicate the existence of necessary events in carcinogenesis, we cannot adopt a univocal (monothetic) definition of cancer. The alternative is to use a polythetic definition, according to Wittgenstein's model of a long rope twisted together out of many shorter fibres. (shrink)

Epidemiology relies upon a broad interpretation of determinism. This paper discusses analogies with the evolution of the concept of cause in physics, and analyzes the classical nine criteria proposed by Sir Austin Bradford Hill for causal assessment. Such criteria fall into the categories of enumerative induction, eliminative induction, deduction and analogy. All of these four categories are necessary for causal assessment and there is no natural hierarchy among them, although a deductive analysis of the study design is preliminary to any (...) assessment. (shrink)

Using the example of air pollution, I criticize a restricted utilitarian view of environmental risks. It is likely that damage to health due to environmental pollution in Western countries is relatively modest in quantitative terms (especially when considering cancer and comparing such damage to the effects of some life-style exposures). However, a strictly quantitative approach, which ranks priorities according to the burden of disease attributable to single causes, is questionable because it does not consider such aspects as inequalities in the (...) distribution of risks. Secondly, the ability of epidemiological research to identify some health effects is limited. Third, the environment has symbolic and aesthetic components that overcome a strict evaluation of damage based on the impairment of human health. It is not acceptable that priorities be set just balancing the burden of disease caused by pollution in the environment against economic constraints. As an example of a computation that inherently includes economic analysis, I refer to the proposal of an estimator of mortality in coal mining, i.e., a rate which puts deaths in the numerator and tons of coal extracted in the denominator. According to this estimator, mortality due to accidents decreased from 1.15 to 0.42 in the period 1950–1970 in the United States, for each million tons of coal extracted. However, considering the steep decline in the workforce in the same period, the traditional mortality rate (deaths over persons-time) actually increased. The proposal of a measure of mortality based on the amount of coal extracted is just one example of the attempts to influence decisions by including an economic element (productivity) in risk assessment. This paper has three purposes: One, to describe empirical research concerning the health effects of environmental pollutants; two, to discuss the scientific principles and methods used in the identification of environmental hazards; and three, to critically discuss some of the ethical principles which are applied in medicine and in the assessment and management of risk. (shrink)

The clinical decision is supposed to be based on evidence. In fact, what counts as evidence is far from being established. Some definition of "proof" is needed to distinguish between scientific medicine and charlatanism. My thesis is that unfortunately a clear-cut boundary between evidence and lack of evidence cannot be found, for several reasons that I summarise in the paper. Evidence in medicine very often has fuzzy boundaries, and dichotomising fuzziness and uncertainty can have serious consequences. Physicians and patients should (...) accept the irreducible fuzziness of many of the concepts they use when dealing with health and disease. (shrink)

The aim of my paper will be to provide a commentary on the introduction to the French edition of Ethics and the Limits of Philosophy (1985) by Bernard Williams (1929–2003) and to show the Nietzschean legacy that is made explicit there. In this introduction, called “L'éthique, question de style?” and published in 1990, Williams reflects on some of the problems of style that his book poses to French readers, to whom he feels his work is less familiar. Furthermore, Williams recalls (...) some moments of the Royaumont colloquium (which he attended in 1958) and dwells on some peculiarities that distinguish him from analytic philosophy, “French” philosophy, Wittgenstein and Heidegger. Finally, the text closes with a description of the image of the philosopher to whom Williams feels closest—that of Nietzsche—and illustrates the reasons that distance him from other models of philosophical writing. (shrink)

The objective of the article is to examine the extensions of a clinical measure of efficacy, the Number Needed to Treat (NNT), in different settings including screening, scanning, genetic testing and primary prevention, and the associated ethical implications. We examine several situations in which the use of the NNT or NNS (Number Needed to Screen) has been suggested, such as Prostate-Specific Antigen for prostate cancer, Magnetic Resonance Imaging scans, genetic testing and banning of smoking. For each application, we explore the (...) ethical implications of the relevant measure. We have found that the different measures have different ethical implications. For example, the Number Needed to Prevent is the only measure that can be lower than one, indicating with a numerical example that prevention is better than cure. Conversely, we raise questions about the acceptability of genetic screening. In a realistic example, we show that primary prevention of the effects of arsenic in drinking water, targeted to the most susceptible, would require to genetically screen a large number of subjects, whereas giving rise to ethical concerns. We warn against the abuse of testing, in particular genetic testing, we show that different measures are associated with different ethical issues and that prevention tends to be better than cure. (shrink)

The literature on indicative conditionals contains two appealing views. The first is the selectional view: on this view, conditionals operate by selecting a single possibility, which is used to evaluate the consequent. The second is the informational view: on this view, conditionals don’t express propositions, but rather impose constraints on information states of speakers. Both views are supported by strong arguments, but they are incompatible on their standard formulations. Hence it appears that we have to choose between mutually exclusive options. (...) But the options are not exclusive. This paper develops a theory of the semantics and assertability of conditionals that is both selectional and informational. The theory vindicates the signature inferences of both selectional and informational theories, including so-called Conditionals Excluded Middle and principles about the interplay between conditionals and ‘might’. It also predicts some interesting and puzzling facts about the assertion of conditionals. (shrink)

Heinrich Behmann (1891-1970) obtained his Habilitation under David Hilbert in Göttingen in 1921 with a thesis on the decision problem. In his thesis, he solved - independently of Löwenheim and Skolem's earlier work - the decision problem for monadic second-order logic in a framework that combined elements of the algebra of logic and the newer axiomatic approach to logic then being developed in Göttingen. In a talk given in 1921, he outlined this solution, but also presented important programmatic remarks on (...) the significance of the decision problem and of decision procedures more generally. The text of this talk as well as a partial English translation are included. (shrink)

This article begins by examining the status of “difference” in representations of perspectivist cosmologies, which are themselves often represented as radically different to Euro-American cosmologi...

Natural language conditionals seem to be subject to three logical requirements: they invalidate Antecedent Strengthening, they validate so-called Simplification of Disjunctive Antecedents, and they allow for the replacement of logically equivalent clauses in antecedent position. Unfortunately, these requirements are jointly inconsistent. Conservative solutions to the puzzle drop Simplification, treating it as a pragmatic inference. I show that pragmatic accounts of Simplification fail, and develop a truthmaker semantics for conditionals that captures all the relevant data. Differently from existing truthmaker semantics, my (...) semantics extends, rather than replaces, standard possible worlds semantics. The main innovation is the notion of a truthmaker in play: this notion is cognitive, rather than metaphysical, and can be defined in a purely syntactic way. (shrink)

This paper investigates the link between informational consequence and credence. I first suggest a natural constraint, namely that informational consequence should preserve certainty: on any rational credence distribution, when the premises of an informational inferences have credence 1, the conclusion also has credence 1. Then I show that the certainty‐preserving constraint leads to triviality. In particular, the following three claims are incompatible: (i) informational consequence is extensionally distinct from classical consequence; (ii) informational inferences preserve certainty; (iii) credences obey (a subset (...) of) classical Bayesian constraints. The proof is straightforward, but the theoretical implications are substantial. Informational theorists need to either give up the idea that credence applies to epistemic discourse, or develop a nonclassical theory of credence and credal update. Moreover, the result also suggests that there is a connection between informational consequence and triviality results, including classical triviality results like Lewis's. (shrink)

That words express a conceptual content is uncontroversial. This does not entail that their content should break down neatly into a grammatical part, relevant for language and to be analyzed in linguistic terms, and a conceptual part, relevant for cognition and to be analyzed in psychological terms. Various types of empirical evidence are reviewed, showing that the conceptual content of words cannot be isolated from their linguistic properties, because it is affected and shaped by them. The view of words as (...) labels or containers for a non-linguistic conceptual content stems from a naive disregard of the complex and structured nature of lexical knowledge. On the contrary, knowledge of language is shown not just to organize and categorize conceptual content in a way not reducible to non-linguistic cognition, but also to affect its scope, as the range of verbalized concepts is both limited by abstract templates and expanded by productive word formation. This suggests that lexical knowledge is a distinctively linguistic dimension of conceptualization, and that words do not so much label or package concepts, as provide an inner form for conceptual knowledge. (shrink)

This paper investigates what happens when we merge two different lines of theorizing about counterfactuals. One is the comparative closeness view, which was developed by Stalnaker and Lewis in the framework of possible worlds semantics. The second is the interventionist view, which is part of the causal models framework developed in statistics and computer science. Common lore and existing literature have it that the two views can be easily fit together, aside from a few details. I argue that, on the (...) contrary, transplanting causal-models-inspired ideas in a possible worlds framework yields a new semantics. The difference is grounded in different algorithms for handling inconsistent information, hence it touches on issues that are at the very heart of a semantics for contrary-to-fact conditionals. Roughly, Stalnaker/Lewis semantics requires us to evaluate the consequent of a counterfactual at all closest antecedent-verifying possibilities. Causal-models-based semantics also does this, but in addition uses the information contained in the antecedent, together with background causal information, to shift what worlds count as closest. This makes systematically different predictions and generates a new logic. The upshot is that we have a new semantics to study, and a substantial theoretical choice to make. (shrink)

According to the orthodox account developed by Kaplan, indexicals like I, you, and now invariably refer to elements of the context of speech. This essay argues that the orthodoxy is wrong. I, you, and the like are shifted by certain modal operators and hence can fail to refer to elements of the context, for example, I can fail to refer to the speaker. More precisely, indexicals are syntactically akin to logical variables. They can be free, in which case they work, (...) roughly, on the Kaplan model. But they can also be bound: this happens, in a systematic fashion, when they are in the scope of epistemic modals or attitude verbs. The new view has two interesting philosophical consequences. First, it vindicates a broadly Fregean perspective on referential expressions, essentially refuting the idea that indexicals are rigid designators. Second, it suggests a new picture of the interaction between context and linguistic meaning: compositional semantics does not need to look at the context and hence has no need for a context parameter. (shrink)

Is it the task of legal semiotics or the legal philosophers to define legal semiotics? For the philosopher of law, the question recalls the distinction between philosophers’ philosophy of law and legal scholars’ philosophy of law. The thesis that the paper argues is that a semiotic legal perspective can also be sought from the analysis of anthropological knowledge on the origin of the social bond and society, implying a social and institutional theory of the mind. In the first paragraph, the (...) search for a different kind of rationality emerges from a semiotician, Jürgen Trabant, who analyses semiotically the thought of a rhetorician and philosopher of law, Giambattista Vico. In the second paragraph, the anthropological notion of social bond emerges from the debate on the relationship between the idea of the gift and that of exchange. In the third paragraph, the analysis of the legal notion of thirdness recognizes the central role of myth and fiction in the configuration of the civil world and sign, returning to Vico’s critical view of the philosophy of language as an institution of society. (shrink)

This volume emphasizes the diversity and fruitfulness of early modern mechanism as a program, as a concept, as a model. Mechanistic study of the living body but also of the mind and mental processes are examined in careful historical focus, dealing with figures ranging from the first-rank (Bacon, Descartes, Spinoza, Cudworth, Gassendi, Locke, Leibniz, Kant) to less well-known individuals (Scaliger, Martini) or prominent natural philosophers who have been neglected in recent years (Willis, Steno, etc.). The volume moves from early modern (...) medicine and physiology to late Enlightenment and even early 19th-century psychology, always maintaining a conceptual focus. It is a contribution to a newly active field in the history and philosophy of early modern life science. It is of interest to scholars studying the history of medicine and the development of mechanistic theories. (shrink)

At the same time, the book is a contribution to recent philosophical debates, in particular on the prospects for a successful nominalist reconstruction of .

The seventeenth century saw dramatic advances in mathematical theory and practice. With the recovery of many of the classical Greek mathematical texts, new techniques were introduced, and within 100 years, the rules of analytic geometry, geometry of indivisibles, arithmatic of infinites, and calculus were developed. Although many technical studies have been devoted to these innovations, Mancosu provides the first comprehensive account of the relationship between mathematical advances of the seventeenth century and the philosophy of mathematics of the period. Starting with (...) the Renaissance debates on the certainty of mathematics, Mancosu leads the reader through the foundational issues raised by the emergence of these new mathematical techniques, including the influence of the Aristotelian conception of science in Cavalieri and Guldin, the foundational relevance of Descartes' Geometrie, the relation between geometrical and epistemological theories of the infinite, and the Leibnizian calculus and the opposition to infinitesimalist procedures. In the process Mancosu draws a sophisticated picture of the subtle dependencies between technical development and philosophical reflection in seventeenth century mathematics. (shrink)

There is an urgent need in philosophy of mathematics for new approaches which pay closer attention to mathematical practice. This book will blaze the trail: it offers philosophical analyses of important characteristics of contemporary mathematics and of many aspects of mathematical activity which escape purely formal logical treatment.

Neuroeconomics, neuromarketing, neuroaesthetics, and neurotheology are just a few of the novel disciplines that have been inspired by a combination of ancient knowledge along with recent discoveries about how the human brain works.This fascinating and thought provoking new book critically questions our love affair with brain imaging.

On an influential line of thinking tracing back to Ramsey, conditionals are closely linked to the attitude of supposition. When applied to counterfactuals, this view suggests a subjunctive version of the so-called Ramsey test: the probability of a counterfactual If A, would B ought to be equivalent to the probability of B, under the subjunctive supposition that A. I present a collapse result for any view that endorses the subjunctive version of the Ramsey test. Starting from plausible assumptions, the result (...) shows that one’s rational credence in a would-counterfactual and in the corresponding might-counterfactual have to be identical. (shrink)

On a popular view dating back to Russell, descriptions, both definite and indefinite alike, work syntactically and semantically like quantifiers. I have an argument against Russell's view. The argument supports a different picture: descriptions can behave syntactically and semantically like variables. This basic idea can be implemented in very different systematic analyses, but, whichever way one goes, there will be a significant departure from Russell. The claim that descriptions are variables is not new: what I offer is a new way (...) of defending it. The argument centers on attitude reports. I argue that we should recognize a new reading of descriptions under attitude reports, which I call ‘singular opaque’. The existence of this reading cannot be explained on the traditional Russellian view, and demands a switch to the variable view. Along the way, some interesting new facts about attitude reports come to light. (shrink)

Know-how and expressivism are usually regarded as disjoint topics, belonging to distant areas of philosophy. This paper argues that, despite obvious differences, the two debates have important similarities. In particular, semantic and conceptual tools developed by expressivists can be exported to the know-how debate. On the one hand, some of the expressivists' semantic resources can be used to deflect Stanley and Williamson's influential argument for factualism about know-how: the claim that knowing how to do something consists in knowing a fact. (...) On the other, expressivism provides the resources to formulate a nonfactualist account of know-how. On this account, know-how has a kind of nonpropositional content and plays the role of guiding performance of action, rather than recording information from the environment. (shrink)

This paper explores the epistemology of extrapolation from model organisms to humans in molecular medicine. We take into account two common views on the issue, the homology view and the disanalogy view. In response to both interpretations, we argue that the foundational basis of extrapolations cannot simply be provided by homology and that relevant disanalogies can, thanks to the techniques of molecular biology, be experimentally controlled and exploited to allow useful and reliable extrapolations. The case of "humanised mice" in the (...) context of cancer stem cell research provides evidence of how animal models can be construed to approximate bona fide causal analogue models of human diseases. To supplement this view we show how the epistemology of model organisms needs to take into account the engineering side of molecular medicine. Model organisms are often manipulated to create analogies or remove disanalogies with the target system. We maintain that highlighting this feature is fundamental to explain what warrants extrapolation in the search for the molecular causes of disease. (shrink)

Paolo Mancosu provides an original investigation of historical and systematic aspects of the notions of abstraction and infinity and their interaction. A familiar way of introducing concepts in mathematics rests on so-called definitions by abstraction. An example of this is Hume's Principle, which introduces the concept of number by stating that two concepts have the same number if and only if the objects falling under each one of them can be put in one-one correspondence. This principle is at the (...) core of neo-logicism. In the first two chapters of the book, Mancosu provides a historical analysis of the mathematical uses and foundational discussion of definitions by abstraction up to Frege, Peano, and Russell. Chapter one shows that abstraction principles were quite widespread in the mathematical practice that preceded Frege's discussion of them and the second chapter provides the first contextual analysis of Frege's discussion of abstraction principles in section 64 of the Grundlagen. In the second part of the book, Mancosu discusses a novel approach to measuring the size of infinite sets known as the theory of numerosities and shows how this new development leads to deep mathematical, historical, and philosophical problems. The final chapter of the book explore how this theory of numerosities can be exploited to provide surprisingly novel perspectives on neo-logicism. (shrink)

From Brouwer To Hilbert: The Debate on the Foundations of Mathematics in the 1920s offers the first comprehensive introduction to the most exciting period in the foundation of mathematics in the twentieth century. The 1920s witnessed the seminal foundational work of Hilbert and Bernays in proof theory, Brouwer's refinement of intuitionistic mathematics, and Weyl's predicativist approach to the foundations of analysis. This impressive collection makes available the first English translations of twenty-five central articles by these important contributors and many others. (...) The articles have been translated for the first time from Dutch, French, and German, and the volume is divided into four sections devoted to (1) Brouwer, (2) Weyl, (3) Bernays and Hilbert, and (4) the emergence of intuitionistic logic. Each section opens with an introduction which provides the necessary historical and technical context for understanding the articles. Although most contemporary work in this field takes its start from the groundbreaking contributions of these major figures, a good, scholarly introduction to the area was not available until now. Unique and accessible, From Brouwer To Hilbert will serve as an ideal text for undergraduate and graduate courses in the philosophy of mathematics, and will also be an invaluable resource for philosophers, mathematicians, and interested non-specialists. (shrink)

Suppose you’re certain that a claim—say, ‘Frida is tall’—does not have a determinate truth value. What attitude should you take towards it? This is the question of the cognitive role of indeterminacy. This paper presents a puzzle for theories of cognitive role. Many of these theories vindicate a seemingly plausible principle: if you are fully certain that A, you are rationally required to be fully certain that A is determinate. Call this principle ‘Certainty’. We show that Certainty, in combination with (...) some minimal side premises, entails a very implausible claim: whenever you’re certain that it’s indeterminate whether A, it is rationally required that you reject A. This is a surprising result, which requires abandoning at least some intuitive views about indeterminacy and cognitive role. (shrink)

In this paper we investigate splitting algebras in varieties of logics, with special consideration for varieties of BL-algebras and similar structures. In the case of the variety of all BL-algebras a complete characterization of the splitting algebras is obtained.

In this paper we investigate splitting algebras in varieties of logics, with special consideration for varieties of BL-algebras and similar structures. In the case of the variety of all BL-algebras a complete characterization of the splitting algebras is obtained.

A significant body of research concludes that stable beliefs of perceived consumer effectiveness lead to sustainable consumption choices. Consumers who believe that their decisions can significantly affect environmental and social issues are more likely to behave sustainably. Little is known, however, about how perceived consumer effectiveness can be increased. We find that feelings of guilt and pride, activated by a single consumption episode, can regulate sustainable consumption by affecting consumers’ general perception of effectiveness. This paper demonstrates the impact that guilt (...) and pride have on perceived consumer effectiveness and shows how this effect rests on the ability of these emotions to influence perceptions of agency. After experiencing guilt or pride, consumers see themselves as the cause of relevant sustainability outcomes. The process of causal attribution associated with these emotions influences consumers’ use of neutralization techniques. Through the reduction in consumers’ ability to neutralize their sense of personal responsibility, guilt and pride positively influence perceived consumer effectiveness. The inability to rationalize-away their personal responsibility, persuades consumers that they affect sustainability outcomes through their decisions. The research advances our understanding of sustainable consumption and identifies a new avenue for the regulation of individual consumer behavior that has significant implications for the development of sustainable marketing initiatives. (shrink)