Free radicals are generally perceived as highly reactive species which are harmful to biological systems. There are, however, a number of enzymes that use carbon‐based radicals to catalyse a variety of important and unusual reactions. The most prominent example is ribonucleotide reductase, an enzyme which is crucial for the synthesis of DNA. In general, radicals are used to remove hydrogen from unreactive positions in the substrate, and in this way the substrate is activated to undergo chemical transformations that would otherwise (...) be difficult to achieve. Several different mechanisms have evolved which allow enzymes to generate and maintain radicals in increasingly aerobic enviroments. An unexpected finding is the existance of stable protein‐based radicals, residing on a variety of amino‐acid side chains, which serve to link the radical‐generating and catalytic sites and to store the radical between turnovers. (shrink)

This collection, the first of its kind, brings together specially commissioned academic essays to mark fifty years since the death of John Kennedy Toole.

An exploratory model is presented as a heuristic to indicate how individual perceptions of corporate reputation (before joining) and corporate ethical values (after joining) generate specific individual organizational senses of fit. The paper suggests that an ethical dimension of person-organization fit may go some way in explaining superior acquisition and retention of staff by those who are attracted to specific organizations by levels of corporate social performance consonant with their ethical expectations, or who remain with them by virtue of better (...) personal ethical fits with extant organizational ethical values. Specifically, the model suggests that individual misfits that arise from ethical expectations that either exceed or fall short of perceived organizational ethical performances lead to problematic acquisition and retention behavioural outcomes. (shrink)

An exploratory model is presented as a heuristic to indicate how individual perceptions of corporate reputation (before joining) and corporate ethical values (after joining) generate specific individual organizational senses of fit. The paper suggests that an ethical dimension of person-organization fit may go some way in explaining superior acquisition and retention of staff by those who are attracted to specific organizations by levels of corporate social performance consonant with their ethical expectations, or who remain with them by virtue of better (...) personal ethical fits with extant organizational ethical values. Specifically, the model suggests that individual misfits that arise from ethical expectations that either exceed or fall short of perceived organizational ethical performances lead to problematic acquisition and retention behavioural outcomes. (shrink)

Significant associations have been found between specific human leukocyte antigen (HLA) alleles and organ transplant rejection, autoimmune disease development, and the response to infection. Traditional searches for disease associations have conventionally measured risk associated with the presence of individual HLA alleles. However, given the high level of HLA polymorphism, the pattern of amino acid variability, and the fact that most of the HLA variation occurs at functionally important sites, it may be that a combination of variable amino acid sites shared (...) by several alleles (shared epitopes) are better descriptors of the actual causative genetic variants. Here we describe a novel approach to genetic association analysis in which genes/proteins are broken down into smaller sequence features and then variant types defined for each feature, allowing for independent analysis of disease association with each sequence feature variant type. We have used this approach to analyze a cohort of systemic sclerosis patients and show that a sequence feature composed of specific amino acid residues in peptide binding pockets 4 and 7 of HLA-DRB1 explains much of the molecular determinant of risk for systemic sclerosis. (shrink)

There is wide agreement that community engagement is important for many research types and settings, often including interaction with ‘representatives’ of communities. There is relatively little published experience of community engagement in international research settings, with available information focusing on Community Advisory Boards or Groups (CAB/CAGs), or variants of these, where CAB/G members often advise researchers on behalf of the communities they represent. In this paper we describe a network of community members (‘KEMRI Community Representatives’, or ‘KCRs’) linked to a (...) large multi-disciplinary research programme on the Kenyan Coast. Unlike many CAB/Gs, the intention with the KCR network has evolved to be for members to represent the geographical areas in which a diverse range of health studies are conducted through being typical of those communities. We draw on routine reports, self-administered questionnaires and interviews to: 1) document how typical KCR members are of the local communities in terms of basic characteristics, and 2) explore KCR's perceptions of their roles, and of the benefits and challenges of undertaking these roles. We conclude that this evolving network is a potentially valuable way of strengthening interactions between a research institution and a local geographic community, through contributing to meeting intrinsic ethical values such as showing respect, and instrumental values such as improving consent processes. However, there are numerous challenges involved. Other ways of interacting with members of local communities, including community leaders, and the most vulnerable groups least likely to be vocal in representative groups, have always been, and remain, essential. (shrink)

There is currently debate between deflationists and anti-deflationists about the ontology of persisting objects. Some deflationists think that disputes between, for example, four-dimensionalists (e.g. Ted Sider and David Lewis) and quasi-nihilists (e.g. Peter Van Inwagen and Trenton Merricks) are merely verbal disputes. Anti-deflationists deny this. Eli Hirsch is a deflationist who maintains that many ontological disputes are merely verbal. Theodore Sider maintains that the disputes are not merely verbal. Hirsch and Sider are thus engaged in a metaontological dispute. In this (...) paper, I argue that Hirsch's metaontological dispute with Sider is, by Hirsch's own lights, itself merely verbal. I conclude that the mere verbalness of his metaontological dispute with Sider suggests that Hirsch's account of what makes a dispute merely verbal may be problematic. (shrink)

Modern approaches to public relations cluster into three camps along a continuum: conflict-oriented egoism, e.g. forms of contingency theory that focus almost exclusively on the wellbeing of an entity; redressed egoism, e.g. subsidies to redress PR's egoistic nature; and forms of self-interested cooperation, e.g. fully functioning society theory. Public Relations, Cooperation, and Justice draws upon interdisciplinary research from evolutionary biology, philosophy, and rhetoric to establish that relationships built on cooperation and justice are more productive than those built on conflict and (...) egoistic competition. Just as important, this innovative book shuns normative, utopian appeals, offering instead only empirical, materialistic evidence for its conclusions. This is a powerful, multidisciplinary, and well-documented analysis, including specific strategies for the enactment of PR as a quest for cooperation and justice, which aligns the discipline of public relations with basic human nature. It will be of interest to scholars and advanced students of public relations and communication ethics. (shrink)

Shifting the focus from fear, guilt, and indignation related to deteriorating environmental quality, the authors hypothesized that people who see greater potential for restorative experiences in natural environments also do more to protect them by behaving ecologically, as with recycling or reduced driving. University students rated a familiar freshwater marsh in terms of being away, fascination, coherence, and compatibility, qualities of restorative person-environment transactions described in attention restoration theory. They also reported on their performance of various ecological behaviors. The authors (...) tested a structural equation model with data from a randomly drawn subset of participants and then confirmed it with the data from a second subset. For the combined subsets, perceptions of the restorative qualities predicted 23% of the variance in general ecological behavior. As the only direct predictor, fascination mediated the influences of coherence, being away, and compatibility. (shrink)

Problem one: why, if God designed the human mind, did it take so long for humans to develop theistic concepts and beliefs? Problem two: why would God use evolution to design the living world when the discovery of evolution would predictably contribute to so much nonbelief in God? Darwin was aware of such questions but failed to see their evidential significance for theism. This paper explores this significance. Problem one introduces something I call natural nonbelief, which is significant because it (...) parallels and corroborates well-known worries about natural evil. Problems one and two, especially when combined, support naturalism over theism, intensify the problem of divine hiddenness, challenge Alvin Plantinga’s views about the naturalness of theism, and advance the discussion about whether the conflict between science and religion is genuine or superficial. (shrink)

Some philosophers have argued for what I call the reason-giving requirement for conscientious refusal in reproductive healthcare. According to this requirement, healthcare practitioners who conscientiously object to administering standard forms of treatment must have arguments to back up their conscience, arguments that are purely public in character. I argue that such a requirement, though attractive in some ways, faces an overlooked epistemic problem: it is either too easy or too difficult to satisfy in standard cases. I close by briefly considering (...) whether a version of the reason-giving requirement can be salvaged despite this important difficulty. (shrink)

In his article entitled 'Divine hiddenness and the demographics of theism' ("Religious Studies", 42 (2006), 177–191), Stephen Maitzen draws our attention to an important feature that is often overlooked in discussion about the argument from divine hiddenness (ADH). His claim is that an uneven distribution of theistic belief (and not just the mere existence of non-belief) provides an atheological challenge that cannot likely be overcome. After describing what I take to be the most pressing feature of the problem, I argue (...) that a hidden premise causes Maitzen to overlook a Molinist solution. The upshot is a softening of the atheological import of the demographic data. (shrink)

“Divine hiddenness”, as the phrase suggests, refers, most fundamentally, to the hiddenness of God, i.e., the alleged fact that God is hidden, absent, silent. In religious literature, there is a long history of expressions of annoyance, anxiety, and despair over divine hiddenness, so understood. For example, ancient Hebrew texts lament God’s failure to show up in experience or to show proper regard for God’s people or some particular person, and two Christian Gospels portray Jesus, in his cry of dereliction on (...) the cross, as experiencing abandonment by God, whom he regarded as “Abba, Father”, an experience shared by many mystics, saints, and ordinary folk of all theistic traditions, described at its worst as “the dark night of the soul”. Understood in this way, divine hiddenness poses an existential problem for those who have such experiences. -/- However, “divine hiddenness” refers to something else in recent philosophical literature, especially since the publication of J.L. Schellenberg’s landmark book, Divine Hiddenness and Human Reason (1993). In this context, it refers to alleged facts about the absence of belief of God, on the basis of which one might think there is no God. For example, Schellenberg argues that, since there are nonbelievers who are capable of a personal relationship with God and who do not resist it, there is no perfectly loving God, while Stephen Maitzen argues that naturalism better explains the “demographics” of nonbelief than theism and Jason Marsh argues that naturalism better explains “natural nonbelief” than theism. Understood in this way, divine hiddenness constitutes putative evidence for atheism. -/- Although some of the recent philosophical literature addresses the problem understood in the first way (e.g., DeWeese-Boyd 2016; Garcia 2002), this entry focuses on divine hiddenness understood in the second way. The first section discusses the relationships between nonbelief and another source of alleged evidence for atheism: evil. The second section states and defends the argument from nonresistant nonbelief. The third section sketches attempts to explain nonresistant nonbelief from a theistic perspective. The fourth section states other responses to the argument from nonresistant nonbelief. The fifth section discusses the argument from the demographics of nonbelief and the sixth section discusses the argument from natural nonbelief. (shrink)

Empathy is a construct that is notoriously difficult to define. Murphy and colleagues argue for leaning into the construct's inherent fuzziness and reverting to what they term a classical definition informed by the observations of philosophers and clinicians: as a dynamic, “unfolding process of imaginatively experiencing the subjective consciousness of another person, sensing, understanding, and structuring the world as if one were that person.” Although consistent with some historical conceptualizations, this definition risks incorporating so many processes it would make empathy (...) difficult to operationalize or distinguish from any generally socially sensitive interaction. Defining empathy instead as the attempted representation, or simulation, of another's subjective internal experiences would increase its clarity and empirical utility. (shrink)

Empathy is a construct that is notoriously difficult to define. Murphy and colleagues argue for leaning into the construct's inherent fuzziness and reverting to what they term a classical definition informed by the observations of philosophers and clinicians: as a dynamic, “unfolding process of imaginatively experiencing the subjective consciousness of another person, sensing, understanding, and structuring the world as if one were that person.” Although consistent with some historical conceptualizations, this definition risks incorporating so many processes it would make empathy (...) difficult to operationalize or distinguish from any generally socially sensitive interaction. Defining empathy instead as the attempted representation, or simulation, of another's subjective internal experiences would increase its clarity and empirical utility. (shrink)

It has been shown that for the Reissner-Nordström solution to the vacuum Einstein field equations charge, like mass, has a unique space-time signature (Marsh, Found. Phys. 38:293–300, 2008). The presence of charge results in a negative curvature. This work, which includes a discussion of effective mass, is extended here to the Kerr-Newman solution.

In lieu of an abstract, here is a brief excerpt of the content:Flipping the DeckOn Totality and Infinity’s Transcendental/Empirical PuzzleJack Marsh (bio)How does one perceive a transcendental condition?— Martin Kavka... if it is legitimate to hold Levinas to the standards that he himself imposes on certain other philosophers.— Robert BernasconiI do not believe that there is a transparency possible in method. Nor that philosophy might be possible as transparency.— Emmanuel LevinasThe question of the precise methodological status of the face has (...) yet to be satisfactorily resolved. The best evidence for this claim perhaps lies in texts intended to introduce Levinas to a general philosophical audience. If even first-rate philosophers wrestle still with the puzzle Totality and Infinity bequeaths us, we seem to still await a full and precise diagnosis. For example, Michael Morgan holds the “face-to-face and the responsible self — they are one thing characterized from [End Page 79] two perspectives — are” “the transcendental condition for meaningful human life,” yet elsewhere concedes, “it is unavoidable that in some sense or other the face-to-face does occur as an actually lived experience.” If Morgan’s own nuanced treatment of this question still lands him in equivocation, the problem is certainly not Morgan’s own.1 As Atterton notes, Morgan must finally hold that Levinas’s method is a “transcendental enterprise of a certain sort.”2 But of what sort? Indeed, this question has been asked or analyzed in one way or another from the beginning of Totality and Infinity’s English-language reception.3 Of course, Derrida was the first to broach the question of Totality and Infinity’s general intelligibility, alleging that Levinas ultimately succumbs to a form of empiricism. Of course, de Boer was the first to mount a rigorous Cartesian reading of the text as an (apparently) “ethical transcendental philosophy.” Of course, Bernasconi’s response to de Boer, and his creative repetition of Derrida’s critical point, was the first to give the problem a precise formulation.4 Derrida, de Boer, and Bernasconi hand us the now canonical problem of what I will call the text’s “transcendental/empirico-metaphysical puzzle.”5 The issue boils down to Levinas’s dual insistence that the face “cannot... be stated in terms of experience,” yet is nevertheless “reflected within experience” (TI 25, 23, 67, 260). How should we understand Levinas’s references to various “formal structure[s]” — “of language,” “of interpellation,” “of the idea of infinity” — next to talk of “pure” or “concrete moral experience” (195, 79, 64, 53)? Does the Other occur in “pure experience,” or is she “deduced” as a condition of possibility for experience in general? In this essay, I will propose an internal explanation for Totality and Infinity’s longstanding methodological puzzle. By proposing to “explain” this puzzle, I am making at least three distinct claims: to show (1) that the text suffers from genuine incoherence, thus confirming the general criticism of Derrida, Bernasconi, and others, (2) precisely how this incoherence follows from the details of Levinas’s own explicit method, and (3) precisely why, philosophically, he may have constructed and performed his method as he did.6 By proposing to explain the book’s incoherence, I can [End Page 80] also make specific hermeneutic predictions. If Totality and Infinity’s transcendental/empirico-metaphysical puzzle is genuinely aporetic, it follows that no resolution to it is possible on the text’s own terms.7 As such, any attempt to resolve the puzzle must either (1) augment the text’s own descriptions, (2) utilize other philosophical resources to render its claims coherent, or (3) precisely attempt resolution in either a transcendental or empirico-metaphysical direction. As it turns out, extant scholarship reflects just these hermeneutic strategies.Over the years many philosophers have contributed to this longstanding debate, variously arguing for or against the general intelligibility of Levinas’s account of the face. On the one hand, scholarship that questions the text’s intelligibility does so from a variety of methodological perspectives.8 On the other hand, scholarship that mounts a defense of the text seems to proceed in one of three ways: by (1) apparently repeating Totality and Infinity’s methodological problems, (2) anticipating Levinas’s later work, read... (shrink)

Stasis is a process of classical rhetoric that identifies the core issue in a trial or a similar debate. Hermagoras of Temnos included the first comprehensive analysis of stasis in his second-century BCE treatise on rhetoric, now lost. Modern scholars tend to echo George Kennedy, who maintains that Hermagoras’ inspiration for the hierarchical structure of stasis is indeterminate. This article, however, employs scholarship in legal semiotics, including the work of Miklós Könczöl and Bernard S. Jackson, to argue that Hermagoras based (...) stasiastic structure on Aristotle’s first-figure syllogism. Ideally, knowledge of that structure can enhance modern applications of stasis. (shrink)

Modern converged mass media, particularly television and the World Wide Web, may be fostering a new orality in opposition to traditional alphabetical literacy. Scholars of orality and literacy maintain that oral cultures feature reduced levels of critical assessment of media messages. An analysis of Aristotle's description of ethos, as presented in that philosopher's Rhetoric, suggests that an oral culture can foster media that deliver selective truths, or even lies, thus ranking poorly in hierarchical ethical schemata such as those developed by (...) Kohlberg, Gilligan, and Baker. (shrink)

Neurodegenerative diseases are becoming increasingly common as life expectancy increases. Recent years have seen tremendous progress in the identification of genes that cause these diseases. While mutations have been found and cellular processes defined that are altered in the disease state, the identification of treatments and cures has proven more elusive. The process of finding drugs and therapies to treat human diseases can be slow, expensive and frustrating. Can model organisms such as Drosophila speed the process of finding cures and (...) treatments for human neurodegenerative diseases? We pose three questions, (1) can one mimic the essential features of human diseases in an organism like Drosophila, (2) can one cure a model organisms of human disease and (3) will these efforts accelerate the identification of useful therapies for testing in mice and ultimately humans? Here we focus on the use of Drosophila to identify potential treatments for neurodegenerative diseases such as Huntington's and we discuss how well these therapies translate into mammalian systems. BioEssays 26:485–496, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

Charge, like mass in Newtonian mechanics, is an irreducible element of electromagnetic theory that must be introduced ab initio. Its origin is not properly a part of the theory. Fields are then defined in terms of forces on either masses—in the case of Newtonian mechanics, or charges in the case of electromagnetism. General Relativity changed our way of thinking about the gravitational field by replacing the concept of a force field with the curvature of space-time. Mass, however, remained an irreducible (...) element. It is shown here that the Reissner-Nordström solution to the Einstein field equations tells us that charge, like mass, has a unique space-time signature. (shrink)

A Levinasian reading of intimate and personal friendship – of friendship “otherwise than political”, as it were – suggests that intimate and personal friendship cannot be subsumed under either completely ethical or completely erotic terms. While friendship can be understood as a certain “fraternity”, and thus be legitimately employed in discussing justice and politics, such a usage trades on a certain equivocation. Hermeneutics seeks to make the alien familiar, and deconstruction seeks to show that the familiar is always (already) alien. (...) As this paper seeks to describe, a Levinasian reading of personal friendship involves both of these movements. In that Levinas, however, never explicitly addresses this relationship, the paper proceeds by sketching the broad contours of his thought before offering a phenomenology of personal friendship in the wake of the limits Levinas thematizes in his analysis of the ethical relation. The readings and analysis presented suggest that personal friendship appears as an irreducible excess, reducible to neither ethics nor enjoyment, while nevertheless passing through ethics and enjoyment. Friendship marks a space of non-violent familiarity and exteriority, a site of solidarity between identity and difference. (shrink)