COVID-19 often manifests with different outcomes in different patients, highlighting the complexity of the host-pathogen interactions involved in manifestations of the disease at the molecular and cellular levels. In this paper, we propose a set of postulates and a framework for systematically understanding complex molecular host-pathogen interaction networks. Specifically, we first propose four host-pathogen interaction (HPI) postulates as the basis for understanding molecular and cellular host-pathogen interactions and their relations to disease outcomes. These four postulates cover the evolutionary dispositions involved (...) in HPIs, the dynamic nature of HPI outcomes, roles that HPI components may occupy leading to such outcomes, and HPI checkpoints that are critical for specific disease outcomes. Based on these postulates, an HPI Postulate and Ontology (HPIPO) framework is proposed to apply interoperable ontologies to systematically model and represent various granular details and knowledge within the scope of the HPI postulates, in a way that will support AI-ready data standardization, sharing, integration, and analysis. As a demonstration, the HPI postulates and the HPIPO framework were applied to study COVID-19 with the Coronavirus Infectious Disease Ontology (CIDO), leading to a novel approach to rational design of drug/vaccine cocktails aimed at interrupting processes occurring at critical host-coronavirus interaction checkpoints. Furthermore, the host-coronavirus protein-protein interactions (PPIs) relevant to COVID-19 were predicted and evaluated based on prior knowledge of curated PPIs and domain-domain interactions, and how such studies can be further explored with the HPI postulates and the HPIPO framework is discussed. (shrink)

The target article by David Alfandre et al. offers a new ethical framework to guide COVID-19 contingency surge planning and response, and applies this ethical framework to three case example...

This review aims at investigating the related studies on the role of teacher burnout and teacher apprehension in learners’ academic achievement. The negative effect of teacher burnout on learners’ academic achievement has been corroborated in the review of the literature. Furthermore, the effect of teacher apprehension on learners’ academic success has not been widely studied. However, some stressors such as having insufficient L2 knowledge, cultural differences, and classroom management problems can affect learners’ academic achievements. Finally, the pedagogical implications are illuminated (...) for teachers, administrators, researchers, managers, teacher trainers, and counselors to decrease teacher burnout and apprehension and to develop language teaching quality in the language educational system. Some suggestions for further research are also provided to expand the current literature on teacher burnout and apprehension in English as a Foreign Language contexts. (shrink)

本书包括“印度各宗概略”、“本体论”、“认识论”、“世间论”四篇,论述了印度各宗与宗教、唯心唯物论、有我无我论、知识本源之问题、宇宙缘起之说明、人生之说明等。.

本书作者通过对中国哲学史上的天、命、阴阳、五行、感应、时、经权、常变、新民、亲民等著名而重要的哲学概念、命题、观念的梳理,勾画出中国思维的基本品质。.

本书从理解与解释的本体论、认识论和方法论三个层次的关系中理解科学解释,解释自然科学与人文、社会科学解释的辨证关系;探讨了科学解释的可能性条件,回答了科学解释何以可能的问题;阐释了科学文本的概念,拓展了 定律解释的标准模式等。.

本书选择并论述的美育范畴,较全面的反映了美育现代性。包括现代美育、审美个性、时间与空间、功利超越与文化超越等内容。.

Our paper draws attention to a neglected channel of corruption—the bribe payments by state-owned enterprises. This is an important phenomenon as bribe payments by SOEs fruitlessly waste national resources, compromising public welfare and national prosperity. Using a large dataset of 30,249 firms from 50 countries, we show that, in general, SOEs are less likely to pay bribes for achieving organizational objectives owing to their political connectivity. However, in deteriorated institutional environments, SOEs may be subjected to potential managerial rent-seeking behaviors, which (...) disproportionately increase SOE bribe propensity relative to privately owned enterprises. Specifically, our findings highlight the importance of fostering democracy and rule of law, reducing prevalence of corruption and shortening power distance in reducing the incidence of SOE bribery. (shrink)

There has been a major international focus on the education and care of toddlers. To date, empirical studies on adults’ interactions in play with toddlers have focussed on the proximity of teachers, teachers’ affective responses, and joint attention between adults and children in play. However, less attention has been given to the role of two teachers working together in supporting children’s exploration of concepts in joint play. This paper takes a cultural-historical perspective and draws upon the concepts of play and (...) subjective positioning to investigate how co-teaching promotes toddlers’ joint play and exploration of mathematical concepts. Visual data of a group of toddlers playing with two teachers is analysed to explore how the teachers applied co-teaching pedagogy to support children’s exploration of mathematical concept. The study argues that co-teaching provides potential to support collective play as two teachers can work collaboratively to address the toddlers’ challenges and needs and support their exploration of the rules and mathematical concepts in play. Co-teaching by paired teachers enables toddlers’ joint play to become more complex, helping the children to explore mathematical concepts and, in turn, further enhancing their play. (shrink)

本书聚焦于第一批判,对其中的哲学概念,术语进行辑录,比类,翻译和集校.注重从德文原著出发,致力于把第一手的康德,原汁原味的康德交给读者,为研究康德者提供一本相对完备的专业辞书.

Independent narration in Chinese philosophy has gone through the process of interpretation, critical differentiation, dialogue, and original thought, and so is a creative activity that surpasses the conjunctive pattern of universality and particularity. In modern Confucian studies, there has always been a tension between philosophical and historical explanations, which suggests a tension between ecumenical and indigenous experiences. Critical differentiation itself only has methodological significance, and is not a goal in itself. China’s development and strength has encouraged China to engage in (...) philosophical dialogue with the West. It is the task and direction of future philosophical creativity to face the contemporary existence, re-construct Confucianism’s relationship with modern life, and respond in a metaphysical and positive manner to the challenges imposed by modernity. (shrink)

The subject of the study is the works of contemporary St. Petersburg artists of different generations and creative trends, as well as the forms and features of their communication with each other and with the general as well as professional public. The trends of artistic communication in the city are determined by the activities of such institutions as art and non-art museums, art galleries and exhibition centers, which are a classic form of presentation of contemporary art; alternative venues such as (...) creative spaces and art clusters. The field of attention also includes the attraction of St. Petersburg authors to the organization of small artistic associations, mainly art groups, for example, "Unconquered", "North-7", "Parasites", etc. In addition to works of art, theoretical works and reflections by researchers of contemporary art in St. Petersburg and the spaces of its public presentation are involved. The methodological basis is the analysis of the works of St. Petersburg masters of the beginning of the XXI century in the context of the development of urban institutions of artistic communication. The research is based on theoretical works devoted to the problem of artistic communication and trends in the current art process. Comparative-interpretative and typological methods are used to compare the works of artists and forms of artistic communication. The problem of artistic communication in the field of fine art in St. Petersburg is becoming the subject of a separate study. This area of city life is currently developing quite dynamically, as new art associations, curatorial practices and alternative classical platforms for the presentation of the work of authors belonging to different generations and art movements are emerging. Traditional museums and galleries, as well as creative spaces, art clusters and other often non-core institutions, such as libraries and cafes, are involved in this process. Against this background, the features of St. Petersburg artistic communication crystallize, which is characterized by a desire to organize communities, to fuse realistic traditions and current trends, to escapism and symbolism, as well as an interest in oriental themes and stylistics. (shrink)

本书包括四个部分的内容:哲理性军事问题的综述、历史性军事问题的反思、现实性军事问题的辨析、未来性军事问题的预见。.

本书是文化哲学著述,对人类历史发展中的许多文化(精神)现象作了个性化的阐释,如人类开始为何要将自然神化,为何既需要上帝又需要尼采,为何后来又否定了神等问题。.

As teams of people increasingly incorporate robot members, it is essential to consider how a robot's actions may influence the team's social dynamics and interactions. In this work, we investigated the effects of verbal support from a robot on human team members' interactions related to psychological safety and inclusion. We conducted a between-subjects experiment where the robot team member either gave verbal support or did not give verbal support to the human team members of a human-robot team comprised of 2 (...) human ingroup members, 1 human outgroup member, and 1 robot. We found that targeted support from the robot had a positive effect on outgroup members, who increased their verbal participation after receiving targeted support from the robot. When comparing groups that did and did not have verbal support from the robot, we found that outgroup members received fewer verbal backchannels from ingroup members if their group had robot verbal support. These results suggest that verbal support from a robot may have some direct benefits to outgroup members but may also reduce the obligation ingroup members feel to support the verbal contributions of outgroup members. (shrink)

This article focuses on the 1952 visit to the Jingjiang Flood Diversion Project, the first large-scale water infrastructure built on the Yangzi river after the founding of the People's Republic of China, by a foreign delegation from the Asia-Pacific Peace Conference. Serving as a form of technology diplomacy, this trip advanced two main purposes for the newly established country – to build up closer ties with ‘foreign friends’ who advocated international peace in the context of the Korean War, and to (...) demonstrate China's own technical capabilities and achievements as part of the national campaign of ‘peaceful construction’ of the early 1950s. I argue that vernacular technologies, which were grounded in indigenous knowledge and practices for water control in the mid-Yangzi region, were essential in shaping China's self-reliant modernization and China's public diplomacy, which targeted individuals without scientific or technical backgrounds. (shrink)