Antigen presentation to CD8+ T cells by MHC class I molecules is essential for host defense against viral infections. Various mechanisms have evolved in multiple viruses to escape immune surveillance and defense to support viral proliferation in host cells. Through in vitro SARS‐CoV‐2 infection studies and analysis of COVID‐19 patient samples, we found that SARS‐CoV‐2 suppresses the induction of the MHC class I pathway by inhibiting the expression and function of NLRC5, a major transcriptional regulator of MHC class I genes. (...) In this review, we discuss the molecular mechanisms for suppression of the MHC class I pathway and clinical implications for COVID‐19. (shrink)

Kei Yoshida’s recent book Philosophy of the Social Sciences: An Introduction is the first introductory textbook on the philosophy of the social sciences written in Japanese. It concisely expounds on a wide range of topics in the discipline, while its explication of those topics is not impartial or neutral as the author himself says. This paper gives a critical review of the book. The first half of it briefly overviews and assesses the book as a whole. The latter half of (...) the paper reconstructs the gist of the author’s exposition of the naturalism/interpretivism debate and criticizes it. (shrink)

Political developments in Japan from the latter part of 2000 to the year 2001 were highlighted by the executive transition from unpopular Yoshiro Mori to exceptionally popular Junichiro Koizumu as the nation's leader.

In his book Bad Beliefs, Neil Levy defends the engineering of our epistemic environment by removing epistemic pollutions and by nudging people through second-order evidence. Although we agree with his core ideas, in this commentary, we aim at supplementing his approach in light of the participation of the general public in science. In the first part, we argue that the issue of participatory epistemic injustice in the scientific community remains unaddressed in Levy’s discussion and that addressing the issue is equal (...) to removing an epistemic pollution. In the second part, we address the issue of transparency in nudging. Here, we discuss the significance of public engagement in controlling the system of nudges to respect our rational and autonomous choices. (shrink)

The propositional fragment L 1 of Leniewski's ontology is the smallest class (of formulas) containing besides all the instances of tautology the formulas of the forms: (a, b) (a, a), (a, b) (b,). (a, c) and (a, b) (b, c). (b, a) being closed under detachment. The purpose of this paper is to furnish another more constructive proof than that given earlier by one of us for: Theorem A is provable in L 1 iff TA is a thesis of first-order (...) predicate logic with equality, where T is a translation of the formulas of L 1 into those of first-order predicate logic with equality such that T(a, b) = FblxFax (Russeltian-type definite description), TA B = TA TB, T A = TA, etc. (shrink)

Job-shop Scheduling Problem (JSP) is one of the most difficult benchmark problems. GA approaches often fail searching the global optimum because of the deception UV-structure of JSPs. In this paper, we introduce a novel framework model of GA, Innately Split Model (ISM) which prevents UV-phenomenon, and discuss on its power particularly. Next we analyze the structure of JSPs with the help of the UV-structure hypothesys, and finally we show ISM's excellent performance on JSP.

Previous studies have revealed the effect of interoceptive accuracy, a behavioral measure of the ability to feel physiological states and regulation for that, which origin emotion on decision-making such as gambling. Given that decision-making in moral dilemma situations is affected by emotion, it seems that IAcc also affects moral decision-making. The present study preliminarily investigates whether IAcc affects decision-making and emotional ratings such as regret for one’s own choices in moral dilemma situations. IAcc did not affect moral choice, but affected (...) regret ratings for one’s moral choice in portions of dilemma scenarios. Moreover, people with higher IAcc make deontological choices more rapidly than those with lower IAcc in self-related dilemma scenarios. These results suggest that people with higher IAcc feel stronger emotional conflicts about utilitarian choices but weaker conflicts about deontological choices than people with lower IAcc depending on the moral dilemma scenario. (shrink)

In this article Kobayashi Toshiaki discusses the importance in all periods of Karatani’s oeuvre of the notion of an “exterior” that necessarily falls beyond the bounds of a system, together with the notion of “singularity” as that which cannot be contained within a “universal.” The existential dread vis-à-vis the uncanny other that Karatani in his early works of literary criticism had initially found to be the underlying tone in Sōseki’s works remained with Karatani himself throughout his career and is (...) what had drawn him closer to philosophy. This sense of the “exterior” to—or other than—the normality of consciousness and the meaningfulness of the world is then extended and applied as the “exterior to systems” in his analyses of logical, mathematical, and linguistic systems, in his reading of Marx’s discussion of capitalist economics, and most recently in his analysis of commodity exchange between communities. (shrink)

Introduction Social anxiety disorder (SAD) symptoms are maintained by cognitive biases, which are overestimations of the severity and likelihood of negative social events (cost/probability biases), and by sensitivity to rewards and punishments that are determined according to behavioral inhibition/behavioral activation systems (BIS/BAS). Cost/probability biases might activate the behavioral immune system and exacerbate the avoidance of social events. Earlier studies have proposed that low BIS or high BAS decrease SAD symptoms; BIS/BAS may even change the effects of cognitive biases on SAD (...) symptoms. Hence, the current study investigates the interaction effects of BIS/BAS and cost/probability biases on SAD symptoms. Method Seventy-six Japanese undergraduate students completed the Japanese version of the Liebowitz Social Anxiety Scale (LSAS), which comprises Fear and Avoidance subscales, the BIS/BAS Scale, and the Social Cost Probability Scale. Results A multiple regression analysis was performed to examine whether cost/probability biases, BIS/BAS, and their interactions affected SAD symptoms; following this, the main effects of cost bias and BIS were determined for LSAS-Fear (β =.64, p <.001; β =.33, p <.01) and LSAS-Avoidance (β =.49, p <.001; β =.35, p <.01). The interaction effect between cost bias and BAS was significant for LSAS-Avoidance (β = −.32, p <.05). Simple slope analysis showed that the slope of cost bias was significant for low-BAS individuals (β =.77, p <.001) but not for high-BAS individuals (β = −.21, n.s.). The interaction effect between probability bias and BAS was significant for LSAS-Avoidance (β =.40, p <.01) as well. Further, simple slope analysis revealed that the slope of probability bias was significant for low-BAS individuals (β = −.53, p <.05) but not for high-BAS individuals (β =.17, n.s.). Discussion The study found interesting results with respect to the avoidance of social events. Low-BAS individuals with high cost or low probability biases regarding social events may have a tendency to avoid social events. In contrast, if high-BAS individuals overestimate the cost of social events or underestimate the probability of social events, their anticipation of rewards might prevent them from avoiding social events. (shrink)

The purpose of this paper is to clarify Prajñākaragupta’s view of mental perception ( mānasapratyakṣa ), with special emphasis on the relationship between mental perception and self-awareness. Dignāga, in his PS 1.6ab, says: “mental [perception] ( mānasa ) is [of two kinds:] a cognition of an [external] object and awareness of one’s own mental states such as passion.” According to his commentator Jinendrabuddhi, a cognition of an external object and awareness of an internal object such as passion are here equally (...) called ‘mental perception’ in that neither depends on any of the five external sense organs. Dharmakīrti, on the other hand, considers mental perception to be a cognition which arises after sensory perception, and does not call self-awareness ‘mental perception’. According to Prajñākaragupta, mental perception is the cognition which determines an object as ‘this’ ( idam iti jñānam ). Unlike Dharmakīrti, he holds that the mental perception follows not only after the sensory perception of an external object, but also after the awareness of an internal object. The self-awareness which Dignāga calls ‘mental perception’ is for Prajñākaragupta the cognition which determines as ‘this’ an internal object, or an object which consists in a cognition; it is to be differentiated from the cognition which cognizes cognition itself, that is, self-awareness in its original sense. (shrink)

Social or relational egalitarians try to defend democracy non-instrumentally as a constitutive element of a society where no one stands as inferior or superior to anyone else. However, they face an instrumentalist challenge from within: Why not uphold a non-democratic regime if it outperforms democracy in protecting or promoting egalitarian social relations, for example, by stably producing substantive political decisions that guard against social hierarchies? This article explores the best response to this challenge from the social egalitarian non-instrumentalist standpoint. It (...) argues that the instrumentalist challenge can be accommodated without abandoning the essential non-instrumentalist commitment to democracy; while a nondemocratic regime may be justified under less-than-ideal circumstances as a contingently effective means to realize more social equality, democracy can nevertheless be viewed as a necessary condition for the realization of full social equality. (shrink)

For a robot to cohabit with people, it should be able to learn people’s nonverbal social behavior from experience. In this paper, we propose a novel machine learning method for recognizing gestures used in interaction and communication. Our method enables robots to learn gestures incrementally during human–robot interaction in an unsupervised manner. It allows the user to leave the number and types of gestures undefined prior to the learning. The proposed method (HB-SOINN) is based on a self-organizing incremental neural network (...) and the hidden Markov model. We have added an interactive learning mechanism to HB-SOINN to prevent a single cluster from running into a failure as a result of polysemy of being assigned more than one meaning. For example, a sentence: “Keep on going left slowly” has three meanings such as, “Keep on (1)”, “going left (2)”, “slowly (3)”. We experimentally tested the clustering performance of the proposed method against data obtained from measuring gestures using a motion capture device. The results show that the classification performance of HB-SOINN exceeds that of conventional clustering approaches. In addition, we have found that the interactive learning function improves the learning performance of HB-SOINN. (shrink)

It has been suggested that preparing to teach and teaching are conditionally effective in enhancing one’s own learning. This paper focuses on interactivity—the level of teacher-student interaction in expected or actual teaching—as the potential key to understanding and controlling the variability in the effectiveness of learning by preparing to teach and teaching. By summarizing and reanalyzing the results of previous studies, I suggest that the learning benefits of studying with the expectation of direct teaching (i.e., teaching a student face-to-face) are (...) greater than those of studying with the expectation of indirect teaching (i.e., teaching a student indirectly by creating a lecture video, providing written explanations, or using other means) and that learning by direct teaching surpasses learning by explaining to oneself or indirect teaching at least after preparing to do so. Next, three candidate explanations for the impact of interactivity are discussed: the advantages of asking and answering questions, obtaining additional information about and from one’s student, and enhancing one’s motivation to process learning material deeply while preparing to teach and teaching. Finally, I conclude with the remaining questions and directions for future research. (shrink)

In this chapter, Kobayashi and Marion first provide reasons to reject the many readings of Collingwood that sought to draft him as a participant in the Hempel-Dray debate about the status of covering laws in history. After all, this debate was not part of Collingwood’s context and, although one can pry from his writings a contribution to it, one may simply, by doing so, misunderstand what he was up to. In the second part, they present the Gabbay-Woods Schema for (...) abductive reasoning, as it occurs in the context of inquiry, as triggered by an ignorance problem, and as being ‘ignorance preserving’. They then argue that this allows us better to see the point of Collingwood’s ‘logic of questions and answers’, as derived from his own practice in archaeology, and his use of the ‘detective model of the historian’, as opposed to merely focussing on understanding what ‘re-enactment’ could mean as a contribution to the Hempel-Dray debate. (shrink)

Après un bref survol de l’esthétique britannique au xxe siècle, les objections de Wollheim à la théorie « idéelle » de l’art, qu’il attribue à Croce et à Collingwood, sont présentées. Dans une deuxième partie, les critiques de Bosanquet à l’endroit de la théorie de Croce sont examinées, pour en conclure qu’on ne peut pas lui attribuer la théorie « idéelle ». Il en va de même pour Collingwood, dont les grandes lignes de son esthétique sont présentées dans la troisième (...) partie, dont le but accessoire est de montrer que sa théorie est par ailleurs plus satisfaisante que celle de Bosanquet ; elle est en réalité très proche de celle de Wollheim, malgré les dires de ce dernier. Dans la conclusion, on revient sur le motif des théories de l’art des idéalistes britanniques, à savoir le rôle social que doit jouer l’oeuvre d’art, pour montrer toute l’actualité de la théorie de Collingwood, pour qui l’oeuvre d’art est le produit non pas de l’artiste seul, mais de l’artiste et de son audience.After a brief survey of British aesthetics in the XXth century, Wollheim’s objections to the ‘ideal’ theory, which he imputes to Croce and Collingwood, are presented. In the second part, Bosanquet’s critique of Croce’s theory is presented in order to show that one cannot attribute to him the ‘ideal’ theory. The same goes for Collingwood, whose aesthetic theory is sketched in the third part, which argues accessorily that it is more satisfactory than Bosanquet’s ; it is in fact, his own claims to the contrary notwithstanding, rather close to Wollheim’s. The conclusion comes back to the central motivation for British Idealist theories of art, namely that the work of art has a social role to play, in order to show the actuality of Collingwood, who viewed the work of art not as the product of the artist alone, but from the artist and the audience alike. (shrink)

The title of Marnie Hughes-Warrington's study, 'How Good an Historian Shall I Be?', is taken from a 1930 pam-phlet by Collingwood, in which, assuming that 'there are as many historians as there are human beings', he inferred that 'the question is not 'Shall I be an historian or not?' but How good an historian shall I be?'' . Hughes-Warrington takes this to be 'probably the most important question we can ask' . Indeed, she believes that 'historical education' is 'a duty (...) that we all must bear for our sake and for the sake of civilisation' . Hughes-Warrington thus situates proper histori-cal education within the wider process of civilization; this leitmotif being taken from Collingwood, for whom educa-tion is the means 'by which a civilisation keeps itself alive from one generation to the next'. (shrink)

Continuing Pfeiffer 1972, Pfeiffer 2018 examines inherited Dravidian etyma of Kurux, one of the most northerly Dravidian languages. After an overview of the book, we discuss problems involved in Pfeiffer’s arguments, methods, and materials. Then we try to narrow down the conditions of some of the sound changes Pfeiffer proposes, in conformity with the Neogrammarian hypothesis of regularity. We also point out that closer study of word-final phonology would answer some of the pending questions of Kurux-Malto morphology. Finally, we argue (...) that phonological and morphological reconstruction can unveil more features to help revise the subgrouping of Kurux-Malto in the Dravidian family. (shrink)

The following dilemma is discussed: On the one hand, the growing impact of Technology of communication and information (ICT) in everyday habits seems to influence the dynamics of public opinion by reinforcing irrational beliefs and creating the impression that the autonomy of people’s opinion and decisions is just a myth. On the other hand, people seem to act most of the time, under the normal circumstances of daily life, in a rational way, as if their habitual actions result from relatively (...) autonomous decisions. A way out of this dilemma is suggested with the hypothesis that people can be rational most of the time, but nevertheless have their opinions influenced by insufficient, distorted information, or by previously acquired emotional dispositions. This hypothesis, in turn, is going to be scrutinized by considering, from a philosophical-interdisciplinary perspective, the role of rational choices in the dynamics of autonomous opinion. With illustrations of diagrams, we claim that the qualitative Complex Systems paradigm might help us to understand the possible role of emotional dispositions in the dynamics of autonomous opinion formation. (shrink)

Objectives: This study aimed to conduct a systematic review and meta-analysis of randomized controlled trials (RCTs) to improve subjective well-being (SWB), including evaluative, hedonic, and eudemonic well-being, and the mental component of quality of life (QOL) of working population. Methods: A literature search was conducted, using PubMed, Embase, PsycINFO, and PsycARTICLES. Eligible studies included those that were RCTs of any intervention, conducted among healthy workers, measured SWB as a primary outcome, and original articles in English. Study characteristics, intervention, outcomes, and (...) results on SWB outcomes were extracted by the investigators independently. After a brief narrative summarizing and classifying the contents of the interventions, the included outcomes were categorized into each aspect of SWB (evaluative, hedonic, and eudemonic well-being, and the mental component of QOL). Finally, the characteristics of the effective interventions for increasing each aspect were summarized, and the pooled effect of interventions on SWB was investigated by a meta-analysis. Publication bias was investigated by drawing a funnel plot and conducting Egger's test. Results: From the 5,450 articles found, 39 met the inclusion criteria for the systematic review. The interventions included in this review were classified into six categories (physical activity, ergonomics, psychological, environmental, multicomponent intervention, and others). The meta-analysis from 31 studies showed that the pooled effect of included interventions on SWB was significantly positive (standardized mean difference (SMD) = 0.51; standard error (SE) = 0.10). A funnel plot showed there were extremely large or small SMDs, and Egger's test was significant. Thus, we conducted sensitivity analysis, excluding these extreme SMDs, and confirmed that the estimated pooled effect was also significantly positive. Subgroup analyses for separate types of interventions showed the effects of psychological interventions (e.g., mindfulness, cognitive behavioral based approach, and other psychological interventions) were also significantly positive. Conclusion: The current study revealed the effectiveness of interventions for increasing SWB. Specifically, psychological interventions (e.g., mindfulness, cognitive behavioral based approach, and other psychological interventions) may be useful for improving SWB. (shrink)

This paper reports on a quiz robot experiment in which we explore similarities and differences in human participant speech, gaze, and bodily conduct in responding to a robot’s speech, gaze, and bodily conduct across two languages. Our experiment involved three-person groups of Japanese and English-speaking participants who stood facing the robot and a projection screen that displayed pictures related to the robot’s questions. The robot was programmed so that its speech was coordinated with its gaze, body position, and gestures in (...) relation to transition relevance places, key words, and deictic words and expressions in both languages. Contrary to findings on human interaction, we found that the frequency of English speakers’ head nodding was higher than that of Japanese speakers in human-robot interaction. Our findings suggest that the coordination of the robot’s verbal and non-verbal actions surrounding TRPs, key words, and deictic words and expressions is important for facilitating HRI irrespective of participants’ native language. Keywords: coordination of verbal and non-verbal actions; robot gaze comparison between English and Japanese; human-robot interaction ; transition relevance place ; conversation analysis. (shrink)

Sex chromosomes in plants have been known for a century, but only recently have we begun to understand the mechanisms behind sex determination in dioecious plants. Here, we discuss evolution of sex determination, focusing on Silene latifolia, where evolution of separate sexes is consistent with the classic “two mutations” model—a loss of function male sterility mutation and a gain of function gynoecium suppression mutation, which turned an ancestral hermaphroditic population into separate males and females. Interestingly, the gynoecium suppression function in (...) S. latifolia evolved via loss of function in at least two sex‐linked genes and works via gene dosage balance between sex‐linked, and autosomal genes. This system resembles X/A‐ratio‐based sex determination systems in Drosophila and Rumex, and could represent a steppingstone in the evolution of X/A‐ratio‐based sex determination from an active Y system. (shrink)

Objective: To clarify whether long time constant is useful for detecting the after-slow activity of epileptiform discharges : sharp waves and spikes and for differentiating EDs from sharp transients.Methods: We employed 68 after-slow activities preceded by 32 EDs and 36 Sts from 52 patients with partial and generalized epilepsy defined by visual inspection. High-frequency activity associated with the apical component of EDs and Sts was also investigated to endorse two groups. After separating nine Sts that were labeled by visual inspection (...) but did not fulfill the amplitude criteria for after-slow of Sts, 59 activities were analyzed about the total area of after-slow under three TCs.Results: Compared to Sts, HFA was found significantly more with the apical component of EDs. The total area of after-slow in all 32 EDs under TC 2 s was significantly larger than those under TC 0.3 s and 0.1 s. Conversely, no significant differences were observed in the same parameter of 27 Sts among the three different TCs. Regarding separated nine Sts, the total area of after-slow showed a similar tendency to that of 27 Sts under three different TCs.Significance: These results suggest that long TC could be useful for selectively endorsing after-slow of EDs and differentiating EDs from Sts. These findings are concordant with the results of the HFA analysis. Visual inspection is also equally good as the total area of after-slow analysis. (shrink)

This volume gathers together for the first time are all the key texts in a crucial debate in modern philosophy, centered on Leibniz's famous 1695 essay, the "New System of the Nature of Substances and their Communication," in which he introduced his strikingly original theory of metaphysics. His "system" became increasingly famous and drew him into discussion and development of these ideas, both in public and in private, with a variety of thinkers, most notably the great French philosopher Pierre Bayle. (...) Woolhouse's and Francks's new English edition gives the only full representation of this debate, and will therefore be essential reading for anyone who wishes to gain a proper understanding of Leibniz's philosophy and its intelletual context. All the texts are newly translated and extensively annotated; many appear in English for the first time. (shrink)

Graphical AbstractYeast mitochondria frequently mutate, and some dysfunctional mitochondria out-compete wild-type versions. The retrograde response enables yeast to tolerate dysfunction, but also produces ribosomal DNA circles (ERCs). We propose that ERC accumulation increases expression of the rDNA antisense gene, TAR1, which counteracts spread of respiration-deficient mitochondria in matings with wild-type yeast.

Genetic Algorithms(GAs) are effective approximation algorithms which focus on “hopeful area” in the searching process. However, in harder problems, it is often very difficult to maintain a favorable trade-off between exploitation and exploration. All individuals leave the big-valley including the global optimum, and concentrate on another big-valley including a local optimum often. In this paper, we define such a situation on conventional GAs as the “UV-phenomenon”, and suggest UV-structures as hard landscape structures that will cause the UV-phenomenon. We introduce a (...) test function which has explicit UV-structures, and show UV-phenomenon caused by them. Next we analyze Fletcher and Powell function to confirm our hypothesis. Finally we propose a novel framework of GAs which can cope with UV-structures. (shrink)

本研究は、史料的裏付けにもとづく、東アジア三地域における気の思想・文化の歴史や内容、特徴を明らかにし、東アジアにおける気の総合的・体系的研究の基礎を構築している。.