An emerging concept is that quiescent mature skeletal cells provide an important cellular source for bone regeneration. It has long been considered that a small number of resident skeletal stem cells are solely responsible for the remarkable regenerative capacity of adult bones. However, recent in vivo lineage‐tracing studies suggest that all stages of skeletal lineage cells, including dormant pre‐adipocyte‐like stromal cells in the marrow, osteoblast precursor cells on the bone surface and other stem and progenitor cells, are concomitantly recruited to (...) the injury site and collectively participate in regeneration of the damaged skeletal structure. Lineage plasticity appears to play an important role in this process, by which mature skeletal cells can transform their identities into skeletal stem cell‐like cells in response to injury. These highly malleable, long‐living mature skeletal cells, readily available throughout postnatal life, might represent an ideal cellular resource that can be exploited for regenerative medicine. (shrink)

Endosteal stem cells are a subclass of bone marrow skeletal stem cell populations that are particularly important for rapid bone formation occurring in growth and regeneration. These stem cells are strategically located near the bone surface in a specialized microenvironment of the endosteal niche. These stem cells are abundant in young stages but eventually depleted and replaced by other stem cell types residing in a non‐endosteal perisinusoidal niche. Single‐cell molecular profiling and in vivo cell lineage analyses play key roles in (...) discovering endosteal stem cells. Importantly, endosteal stem cells can transform into bone tumor‐making cells when deleterious mutations occur in tumor suppressor genes. The emerging hypothesis is that osteoblast‐chondrocyte transitional identities confer a special subset of endosteal stromal cells with stem cell‐like properties, which may make them susceptible for tumorigenic transformation. Endosteal stem cells are likely to represent an important therapeutic target of bone diseases caused by aberrant bone formation. (shrink)

This article develops an axiom system to justify an additive representation for a preference relation ${\succsim}$ on the product ${\prod_{i=1}^{n}A_{i}}$ of extensive structures. The axiom system is basically similar to the n-component (n ≥ 3) additive conjoint structure, but the independence axiom is weakened in the system. That is, the axiom exclusively requires the independence of the order for each of single factors from fixed levels of the other factors. The introduction of a concatenation operation on each factor A i (...) makes it possible to yield a special type of restricted solvability, i.e., additive solvability and the usual cancellation on ${\prod_{i=1}^{n}A_{i}}$ . In addition, the assumption of continuity and completeness for A i implies a stronger type of solvability on A i . The additive solvability, cancellation, and stronger solvability axioms allow the weakened independence to be effective enough in constructing the additive representation. (shrink)

The project of the comprehensive reform of Japanese insolvency law started in October 1996. After many enactments and amendments, there are now two types of judicial proceedings for personal insolvencies in Japanese insolvency law. The first category is straight bankruptcy proceedings in which the debtor can be discharged; the other is special Civil Rehabilitation proceedings for individual debtors. In this Article, I will first give a brief overview of the special Civil Rehabilitation proceedings for individual debtors, including a short description (...) of two types of proceedings, and legislative issues. Then I will give a brief overview of major amendments of the Bankruptcy Law concerning individual bankruptcies, including amendments relating to the scope of exemption and discharge proceedings. (shrink)

Senshu University has hosted many international conferences on medieval English literature - primarily on Geoffrey Chaucer and William Langland - as well as in the related fields of Old Germanic, medieval French and Renaissance Italian literature. These international collaborations inform and contribute to the present volume, which addresses the heritage bequeathed to medieval English language and literature by the classical world.<BR> This volume explores the development of medieval English literature in light of contact with Germanic and Old Norse cultures, on (...) the one hand, and Romance languages, on the other. The book includes a comparative study of <I>Beowulf in the Germanic context, discusses aspects of <I>Piers Plowman and its tradition, and offers philological approaches to Chaucer (especially his <I>Troilus and Criseyde). The articles assembled here collectively suggest how the torches of classical learning were carried from continental Europe to illuminate the pages of medieval English literature. (shrink)

松下幸之助是日本著名的企业家,他除了出色地进行经营管理之外,还在晚年以谈话录的形式,对人生的各种问题进行了总结。本书是从他的谈话集中精选的,涉及到奠定人生大厦的基石、智慧的思考、处理人际关系、不怕挫折 、领导艺术等多方面的内容。.

Although modern education is expected to solve social problems, it has brought about new problems. While theoretical critiques of education have not always been successful, with the transition to a data-driven society, education as a historical product is actually losing its efficacy. However, this does not mean that acquisition of knowledge and skills is becoming unnecessary. Prompted by the need to change the purpose of public education, we are forced to rethink the nature of education boldly. Competency-based education, as advocated (...) by the OECD, appears to have led to such rethinking; however, it is widely accepted as a revised version of modern education. If this trend continues, the contradiction between education and society will deepen further. To overcome this contradiction, we must change our view of education. With education and learning having an asymmetrical relationship to begin with, the clue to changing our view of education lies in re-examining our view of learning. A more comprehensive way of learning that has accompanied human history is attracting the attention of various disciplines. I present a redefined framework for learning that is inherent to humans, which I call the ecological view of learning, and explore an alternative to modern education, learning from the Japanese thought on ‘Manabi (learning).’. (shrink)

Background: Long working hours and mental health problems among teachers are a concern in Japan. More specifically, it has been reported that junior high school teachers tend to work overtime. In this study, examined the working hours of junior high school teachers in public schools and investigated the association between overtime work and stress responses across job titles.Methods: From June to December 2018, 54,772 teachers in public junior high schools completed a web-based nationwide survey regarding occupational stress and submitted self-evaluated (...) working hours per day of the previous month. Psychological and physical stress responses were assessed using the Brief Job Stress Questionnaire.Results: Results showed that 59.6% of the participants worked 11 h or more per day. Additionally, the length of working hours significantly differed across job titles = 5295.8, p < 0.001, Cramér’s V = 0.14). With respect to tenured teachers, sex, age, taking charge of the class, number of working years in the same school, working hours of 10 to 11 h, 11 to 12 h, 12 to 13 h, and 13 h or more were significantly associated with high stress, compared to those who worked less than 9 h per day. Moreover, for fixed-term teachers, sex, age, working hours of 9 to 10 h, 10 to 11 h, 11 to 12 h, 12 to 13 h, and 13 h or more were related with more stress as compared to those who worked less than 9 h per day. On the other hand, there was no significant relationship between long working hours and stress response among vice-principals, even though they tended to work the longest hours.Conclusion: We verified that Japanese junior high school teachers work long hours. Long working hours were associated with stress responses in both tenured and fixed-term teachers, but not in vice-principals. However, vice-principals work the longest hours among teachers, and we suggest that these long working hours may be a hidden problem that is often overlooked. (shrink)

Under the presupposition that human time perception is distorted in intertemporal choice, this study constructs a time scale in the framework of axiomatic measurement. First, the conditions (homogeneity of degree one or two) to identify the form of a time scale are proposed so that one can determine whether the hyperbolic or exponential is a more suitable function for modeling people’s discounting. Homogeneity of degree one implies that subjective time delay is measured by a power scale and its discount function (...) becomes a power-exponential type, whereas homogeneity of degree two implies that subjective time delay is measured by a log scale and its discount function becomes a hyperbolic type. Second, a method is shown for constructing a model that can reflect subadditive and superadditive discounting. A non-commutative and non-associative concatenation operation is provided to generate a time string consisting of subdivided durations that incorporates the effect of repeated delay with a subdivided duration. The discounting model is yielded by substituting these strings in an exponential model equipped with a generalized time scale, and the determination of subadditivity or superadditivity depends on whether the discount function value of a product by the non-commutative and non-associative operation is, respectively, smaller or greater than that of a product by an operation of the usual extensive structure. (shrink)

"El amor en su singularidad erótica es tratado en esta obra desde el auspicio de la poesía y la filosofía, las cuales nos llevan de la mano a los desolados parajes del mundo biológico-psíquico para retener aquello de lo que "no se puede decir nada". Aun así, no es éste un intento de explicar fenomenológicamente el amor, sino una modesta evocación de los momentos y comportamientos humanos en su tránsito hacia el Eros y la experiencia que de ellos se ha (...) obtenido."-- Cubierta trasera. (shrink)

‘Substance’ (substantia, zelfstandigheid) is a key term of Spinoza’s philosophy. Like almost all of Spinoza’s philosophical vocabulary, Spinoza did not invent this term, which has a long history that can be traced back at least to Aristotle. Yet, Spinoza radicalized the traditional notion of substance and made a very powerful use of it by demonstrating – or at least attempting to demonstrate -- that there is only one, unique substance -- God (or Nature) -- and that all other things are (...) merely modes or states of God. Some of Spinoza’s readers understood these claims as committing him to the view that only God truly exists, and while this interpretation is not groundless, we will later see that this enticing and bold reading of Spinoza as an ‘acosmist’ comes at the expense of another audacious claim Spinoza advances, i.e., that God/Nature is absolutely and actually infinite. But before we reach this last conclusion, we have a long way to go. So, let me first provide an overview of our plan. In the first section of this paper we will examine Spinoza’s definitions of ‘substance’ and ‘God’ at the opening of his magnum opus, the Ethics. Following a preliminary clarification of these two terms and their relations to the other key terms defined at the beginning of the Ethics, we will briefly address the Aristotelian and Cartesian background of Spinoza’s discussion of substance. In the second section, we will study the properties of the fundamental binary relations pertaining to Spinoza’s substance: inherence, conception, and causation. The third section will be dedicated to a clarification of Spinoza’s claim that God, the unique substance, is absolutely infinite. This essential feature of Spinoza’s substance has been largely neglected in recent Anglo-American scholarship, a neglect which has brought about an unfortunate tendency to domesticate Spinoza’s metaphysics to more contemporary views. The fourth section will study the nature of Spinoza’s monism. It will discuss and criticize the interesting yet controversial views of the eminent Spinoza scholar, Martial Gueroult, about the plurality of substances in the beginning of the Ethics; address Spinoza’s claim in Letter 50 that, strictly speaking, it is improper to describe God as “one”; and, finally, evaluate Spinoza’s kind of monism against the distinction between existence and priority monism recently introduced into the contemporary philosophical literature. The fifth and final section will explain the nature, reality, and manner of existence of modes. We therefore have an ambitious plan; let’s get down to business. (shrink)

Maquiavelo y su tiempo.--Reacción de algunos escritores españoles de los siglos XVII y XVIII ante la doctrina de Maquiavelo.--El maquiavelismo y las prácticas de gobierno.

Planteamiento de la naturaleza, de la filosof a y de su raz n hist rica, al contemplar panor micamente la totalidad de su pasado e intentar reconstruir el dram tico suceso de su origen.

DICTIONARY OF SPANISH VERBS WITH THEIR ENGLISH EQUIVALENTS AND MODELS OF CONJUGATION/DICCIONARIO CON LOS VERBOS EN ESPAÑOL, SU TRADUCCIÓN AL INGLÉS Y CONJUGACIONES.

A finales de la década de los ‘80, Matsushita Electric Industrial Co. Ltd. largó a la venta la primera máquina panificadora de uso doméstico. Su lanzamiento gozó de tal éxito, que sociólogos del conocimiento se abocaron a analizar el conocimiento involucrado en su diseño y producción. Para ello, Takeuchi y Nonaka (1995) analizaron detalladamente la noción de conocimiento tácito (POLANYI, 1966/2009). Defendieron que los ingenieros y desarrolladores lograron explicitar y traducir el conocimiento tácito presente en el ejercicio habilidoso del (...) maestro panadero al diseño de la máquina de hacer pan, reproduciendo el mismo resultado práctico. En el presente trabajo, discutiré su interpretación de la noción de conocimiento tácito y defenderé que el conocimiento tácito involucrado en el ejercicio de habilidades prácticas no puede explicitarse y traducirse en el diseño de la máquina de hacer pan sin perder, al menos, una parte sustancial de dichas habilidades. Para ello, me valdré de aportes de la sociología de la ciencia y de la fenomenología para argumentar que el conocimiento tácito involucrado en el ejercicio habilidoso de nuestro maestro panadero depende de una relación de familiaridad con el entorno. Dicha relación es epistémicamente relevante en la medida en que involucra representaciones aspectuales de nuestro entorno, las cuales permiten guiar la acción de nuestro maestro panadero. A diferencia, la máquina de hacer pan no posee tales representaciones y, en consecuencia, no puede implicar, al menos, el mismo tipo de conocimiento tácito como guía de su comportamiento. (shrink)

1. Escritos doctrinales -- 2. Escritos histórico-filosóficos.