Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

El presente artículo es un estudio comparativo donde se argumenta la relación disonante entre las obras de Schmitt y Benjamin sobre la estética barroca. Se defiende que la diferencia entre ambos consiste en su concepción de lo político. Para Benjamin, son dos los aspectos fundamentales del Trauerspi..

El presente artículo es un estudio comparativo donde se argumenta la relación disonante entre las obras de Schmitt y Benjamin sobre la estética barroca. Se defiende que la diferencia entre ambos consiste en su concepción de lo político. Para Benjamin, son dos los aspectos fundamentales del Trauerspiel alemán: 1) la diferencia entre drama barroco y tragedia clásica y 2) el recurso a la alegoría como técnica de expresión. Schmitt, por su parte, encuentra lo singular del drama barroco en la irrupción (...) del tiempo histórico-político dentro de la forma estética. Para el crítico berlinés, lo alegórico debe estudiarse desde la filosofía de la historia, mientras que para Schmitt lo decisivo es lo político, ejecutado a través de la soberanía y la decisión. Tal es la línea argumental del presente estudio. This paper is a comparative study about the Works of Benjamin and Schmitt on the baroque art. It argues that the specific difference between them most be found in their concept of the political. For Benjamin there is a difference between tragedy and drama, the german Trauerspiel it is an allegorical approach to thingsand history. Schmitt argues that the singularity of baroque drama is the irruption of time in the plastic form. These are the points that the paper proposes. (shrink)

El objetivo de este ensayo es exponer la experiencia del pensar en obra, propia de una escritura filosófica que asume la singularidad de la configuración literaria en su más originario significado, como palabra memorable que testifica dicha experiencia, asumiéndola como problema del conocimiento. Intentaremos exponer este gesto que unifica diversas construcciones filosóficas que se han caracterizado por ofrecer un tramo de pensamiento en medio de la acción escritural, como punto de vista posible, como vía de acceso al recorrido de un (...) problema. Asumiendo que los límites entre filosofía y literatura se difuminan en una prosa que se deja guiar por la experiencia formativa –Bildung–nos inmiscuimos en la actualización de Miguel Morey desde el uso singular de la caja de herramientas de Nietzsche, junto a la compañía poética y filosófica de María Zambrano y Walter Benjamin. (shrink)

Introduction: the advance of governmentality -- Foucault, power, and governmentality: introduction; what is governmentality?; beyond the microphysics of power?; from theory of the state to genealogy of the state; history of the art of government; pastoral power; raison d'état; liberal governmentality; five propositions on foucault and governmentality -- Governmentality 3.4.7.: introduction; governmentality after Foucault; governmentality and the political sciences; some problems in governmentality -- Foucault effect redux? some notes on international governmentality studies: constellation; a few preliminary observations; problems and debates (...) in international governmentality studies -- Reconnecting governmentality and genealogy: introduction; genealogy and governmentality; pluralizing genealogy; practicing genealogy; lines of descent: the family tree of power?; counter-memory and re-serialization; the retrieval of forgotten struggles and subjugated knowledges -- Conclusion: encountering governmentality: governmentality as a new cartography of power; from mapping to encountering; governmentality and politics. (shrink)

The Architectonics of Meaning is a lucid demonstration of the purposes, methods, and implications of philosophical semantics that both supports and builds on Richard McKeon's and other noted pluralists' convictions that multiple philosophical approaches are viable. Watson ingeniously explores ways to systematize these approaches, and the result is a well-structured instrument for understanding texts. This book exemplifies both general and particular aspects of systematic pluralism, reorienting our understanding of the realms of knowing, doing, and making.

Are demands for equality motivated by envy? Nietzsche, Freud, Hayek, and Nozick all thought so. Call this the Envy Objection. For egalitarians, the Envy Objection is meant to sting. Many egalitarians have tried to evade the Envy Objection.. But should egalitarians be worried about envy? In this paper, I argue that egalitarians should stop worrying and learn to love envy. I argue that the persistent unwillingness to embrace the Envy Objection is rooted in a common misunderstanding of the nature of (...) the charge, what it reveals, and what can be said in response to it. I develop what Bernard Williams might call a vindicatory genealogy of envy, thereby allowing us to see that envy, rather than undermining egalitarian intuitions, can in fact play a distinct justificatory role (when it is fitting), which undermines the Envy Objection. (shrink)

With increased visibility of trans people comes increased philosophical interest in gendered language. This chapter aims to look at the research on gendered language in analytic philosophy of language so far, which has focused on two concerns: (1) determining how to define gender terms like ‘man’ and ‘woman’ such that they are trans inclusive and (2) if, or to what extent, we should use gendered language at all. We argue that the literature has focused too heavily on how gendered language (...) can harm trans people, and has not considered how trans people use gendered language to create meaning and joy for ourselves. Pulling from the literature in sociolinguistics, we look at examples of how trans people use language to make their lives better by gaining recognition, playing with gendered language, finding joy in gendered language, and taking control of definitional power, concluding that debates about gendered language need to consider not only how such language harms trans people but also how trans people use it for our own liberation. (shrink)

Contribución de eruditos autores sobre aspectos trascendentales de la teoría pura del derecho. Esta obra debe verse como una expresión de esa renovada ocupación con los problemas de la doctrina de Kelsen.

El profesor Robert Walter, el más eminente representante de la Teoría Pura del Derecho en nuestro tiempo, estudia en "Hans Kelsen, la Teoría Pura del Derecho y el problema de la justicia" y "Normas y enunciados sobre normas", los dos textos que componen esta obra, los puntos centrales del pensamiento filosófico y jurídico de Hans Kelsen.

Dorothy Edgington’s work has been at the centre of a range of ongoing debates in philosophical logic, philosophy of mind and language, metaphysics, and epistemology. This work has focused, although by no means exclusively, on the overlapping areas of conditionals, probability, and paradox. In what follows, I briefly sketch some themes from these three areas relevant to Dorothy’s work, highlighting how some of Dorothy’s work and some of the contributions of this volume fit in to these debates.

Se resume en esta obra el vasto y complejo sistema teórico-jurídico de Hans Kelsen, el jurista más grande de nuestro siglo. La doctrina de Kelsen y en particular su Teoría Pura del Derecho han conocido muchas vicisitudes y ataques debidos más a prejuicios políticos y racistas que a una verdadera confrontación con sus tesis. El autor enfatiza en el hecho de que la doctrina jurídica de Kelsen no es una teoría terminada y archivada sino en permanente desarrollo, una teoría a (...) cuya ulterior construcción están convocados todos los juristas. (shrink)

Based on a comparison of various sources, such as different editions, correspondence, reviews, and lecture transcripts, it is shown that Ludwig Heinrich Jakob’s Outline of the General Logic and Critical Elements of Metaphysics in General uses one or more transcripts of Kant’s Logic Lectures as a source. In addition to the thus far known texts by Kiesewetter and Hippel, Jakob’s textbook should therefore also be added to the list of secondary transmissions of Kant’s Logic Lectures.

An alarming number of philosophers and cognitive scientists have argued that mind extends beyond the brain and body. This book evaluates these arguments and suggests that, typically, it does not. A timely and relevant study that exposes the need to develop a more sophisticated theory of cognition, while pointing to a bold new direction in exploring the nature of cognition Articulates and defends the “mark of the cognitive”, a common sense theory used to distinguish between cognitive and non-cognitive processes Challenges (...) the current popularity of extended cognition theory through critical analysis and by pointing out fallacies and shortcoming in the literature Stimulates discussions that will advance debate about the nature of cognition in the cognitive sciences. (shrink)

El presente artículo aborda los engranajes entre escritura y ciudadanía que plantea el poemario de Elvira Hernández, Estado de sitio. Para ello, considera los factores de orden sociocultural que acompañaron su producción, circulación y recepción crítica, en el contexto del estallido social de octubre 2019 en Chile, la coyuntura feminista y el actual proceso constituyente. Hitos de nuestra historia reciente frente a los cuales la poeta se posiciona ética y estéticamente desde una concepción política de la palabra como litigio, (...) esto es, una disputa –discursiva y social– por la enunciación de (en) lo común. (shrink)

This book traces the development of British psychoanalyst Marion Milner's (1900-1998) autobiographical acts throughout her lifetime, proposing that Milner is a thinker to whom we can turn to explore the therapeutic potentialities of autobiographical and creative self-expression. Milner's experimentation with aesthetic, self-expressive techniques are a means to therapeutic ends, forming what Emilia Halton-Hernandez calls her 'autobiographical cure'. This book considers whether Milner's work champions this site for therapeutic work over that of the relationship between patient and analyst in the psychoanalytic (...) setting. This book brings to light a theory and practice which is latent and sometimes hidden, but which is central to understanding what drives Milner's autobiographical work. It is by doing this work of elucidation and organisation that Halton-Hernandez finds Milner to be a thinker with a unique take on psychoanalysis, object relations theory, creativity, and autobiography, working at the interstices of each. Divided into two fascinating sections exploring Milner's distinctive method and the legacy and influence of her work, this book will appeal to psychoanalysts, art therapists, philosophers, and art and literary researchers alike. (shrink)

This paper compares pair and Mob programming in university courses from students' perceptions of technical and human aspects. Wilcoxon signed rank tests were performed. Results indicated that students preferred pair programming in technical aspects and in a global evaluation they completed.

The debate between the theory‐theory and simulation has largely ignored issues of cognitive architecture. In the philosophy of psychology, cognition as symbol manipulation is the orthodoxy. The challenge from connectionism, however, has attracted vigorous and renewed interest. In this paper I adopt connectionism as the antecedent of a conditional: If connectionism is the correct account of cognitive archi‐tecture, then the simulation theory should be preferred over the theory‐theory. I use both developmental evidence and constraints on explanation in psychology to support (...) this claim. (shrink)

In deduction the truth of the premises guarantees the truth of the conclusion because the conclusion is contained in the premises; because of that many philosophers have denied the possibility of gaining knowledge through deduction or through deductive reasoning, which leads to a problem known as the paradox of inference. To address this problem, I propose a distinction between deductive reasoning as a cognitive process capable of generating new knowledge, and implication as a logical relation between propositions, which accounts for (...) deduction’s validity, and I present scientific evidence to underpin this proposal. En la deducción la verdad de las premisas garantiza la verdad de la conclusión porque la conclusión está contenida en las premisas; por ello varios filósofos han negado la posibilidad de obtener conocimientos a través de la deducción o del razonamiento deductivo, dando lugar a un problema que se conoce como paradoja de la inferencia. Pare enfrentar este problema propongo distinguir entre el razonamiento deductivo como proceso cognitivo capaz de generar conocimientos nuevos y la implicación deductiva como una relación lógica entre proposiciones que da cuenta de la validez de la deducción, y presento evidencia científica que apoya esta propuesta. (shrink)

As in other countries, medical ethics in Mexico has rescued the world of philosophical ethics from oblivion. The needs of clinical medicine gave birth to Mexican bioethics. After the growth of scientific and technologic subjects in medical schools, the humanities, such as medical history, deontology, and medical philosophy, were replaced by such core subjects as radiology, pharmacology, and microbiology. Since the 1950s, graduates from Mexican medical schools have not been exposed to any courses in the medical humanities.

This study examines the relationship between cooperative business relations in small businesses and environmental protection, one of the most important policies of social responsibility in manufacturing. We reviewed the literature and carried out an empirical study of 930 small manufacturing firms in Spain. Results indicate that small businesses that maintain and improve their cooperative relations through business networking with universities, competitors, suppliers and customers spend more on environmental protection. The managerial, practical, research and policy implications of the obtained research findings (...) are discussed. (shrink)

The present collection of translations arises from our work within Writing Urban Places, a network of researchers interested in the different ways citizens appropriate meaningful built environments through stories, and in doing so are also better able to integrate with others. A key locus in this respect is what our network has termed the ‘mid-sized’ [or ‘intermediate’] European city. Often afforded only cursory attention in the discussion of both culture and society, overlooked in favour of more usual suspects, such urban (...) places allow for a more de-centred, and on occasions regionally focused, view of urban practices, even as they play host to a significant element of contemporary European life and experience. The quest for meaningfulness and appropriation of the urban environment through co-creative, adaptive, and transformative processes (many of which have a textual quality) became central to the theoretical framework of this initiative. Between the individual places in which such processes could be observed and documented, we hypothesized, arises the problem of intermediation – the move from place to place, and its techniques. Translation, more than a textual practice among others, emerged as a structuring consideration of the project at a European scale. Other Destinations is the outcome of this collective process presented here, offering entry into this work to an English-language readership for the first time. We hope that, even as they bring their cities of origin somewhat closer to a new readership, those readers will be uprooted and moved some distance in the direction of these ‘other destinations.’ -/- The edited volume Other Destinations. Translating the Mid-sized European City thus features English translations of 15 21st century (mainly) literary texts published in different media (books, podcasts, journals, online/social media) originally written in languages other than English and that have not previously been translated into English. The selected texts cover the topic of mid-sized European cities, where mid-sized does not solely refer to the size in terms of geographical scope or the number of inhabitants, but also to their socio-historical context of urban identity where these cities are neither metropolises nor small towns, but “other”, lesser-known European cities. The texts selected to be translated in this edited volume cover cities like Volos, Canakkale, Varna, Plovdiv, Durres, Tirana, Porto, Den Haag, Osijek, Salzburg, Naples, Zrenjanin, Loule and others…. The publication intends to enhance the dissemination and accessibility to an international readership of texts about overlooked urban contexts, “other”, lesser-known European cities, their stories and signifying practices in order to develop a better awareness of these cities, their self-constructions, and their responses to the challenges of the present. (shrink)

Como parte de las sucesivas modificaciones al marco jurídico que regula el sistema educativo mexicano, la rendición de cuentas basada en evidencias se ha convertido en una nueva responsabilidad para los docentes del nivel básico. No obstante, se sabe poco acerca de qué significa para los docentes, cómo la han asumido, más aún, qué efectos ha provocado en la práctica cotidiana. Por tal motivo, se realizó un estudio cuyo propósito fue analizar los efectos de la rendición de cuentas en el (...) trabajo docente, con particular atención a la dimensión pedagógica. Mediante entrevistas semiestructuradas a diez docentes de escuelas públicas de la Ciudad de México, se encontró lo que denominamos una autonomía relativa, limitada y mediada por múltiples disposiciones normativas; la invención de realidades como estrategia para cumplir con la entrega de informes y toda clase de evidencias requeridas por diversas autoridades; una idoneidad multitarea, reflejada en una multiplicidad de actividades más allá de la enseñanza; finalmente una profesionalización mecanicista, es decir, una búsqueda constante de cursos y talleres por cuenta propia pero siempre sobre temas y contenidos instrumentales. (shrink)

El debate reciente iniciado por Hubert Dreyfus y John McDowell ha llamado la atención sobre la relación entre racionalidad y acción no reflexiva. En este artículo propongo una forma de especificar el desacuerdo entre quienes llamaré intelectualistas y antiintelectualistas. A la luz de esta propuesta arguyo que el principal argumento antiintelectualista sólo tiene éxito si se acepta al menos uno de tres presupuestos implícitos que están lejos de ser autoevidentes y cuya verdad es puesta en duda por fenómenos familiares. Termino (...) con consideraciones que sugieren que el intelectualista ha quedado en una mejor posición argumentativa. (shrink)

The assembly of products or components by operators in industries is a complex task with recurring problems. In these processes, operators often make errors that can lead to defective products. Therefore, they need to be inspected later to verify their correct assembly. The main problems are caused by several reasons including high employee turnover, lack of experience in manufacturing specific products or confusion in interpreting instructions to assemble similar components. In this paper, a novel structured language aimed to describe the (...) required actions to manufacture a product in industrial assembly environments is presented. The main contribution is to provide a formal language to feed automatic systems that can verify through visual control whether the actions performed by the operator are carried out following the standard described by this language. In general, the use of this formal language will allow to minimize the negative impact of errors during assembly and to reduce waste in many forms in the industry. (shrink)