In response to earlier papers in Informal Logic by Robert Fogelin and Andrew Lugg, this paper explores the issue of whether disagreement could ever be so deep that it defied rational resolution. Contra Lugg, I agree with Fogelin that such unresolvable disagreement is possible and, contra Fogelin, I suggest that the focus of such disagreement can be quite Iimited-a single proposition rather than a whole system of beliefs. I also suggest that emphasising arguing as a human practice rather than arguments (...) as a structure of propositions is unhelpful to consideration of these issues. (shrink)

This book is aimed at those studying for entry into the various professions where ethical questions are commonly faced such as teaching or social work.

Winston Nesbitt has argued that the usual examples appealed to as supporting the view that killing is no worse than letting die are misleading in that the comparison cases are not set up properly to tap our intuitions. Making various adjustments to the cases he judges killing to be intuitively worse than letting die and suggests that such a result is meta‐ethically appropriate to one view of the point of ethics. I contest each of these claims.

Winston Nesbitt has argued that the usual examples appealed to as supporting the view that killing is no worse than letting die are misleading in that the comparison cases are not set up properly to tap our intuitions. Making various adjustments to the cases he judges killing to be intuitively worse than letting die and suggests that such a result is meta‐ethically appropriate to one view of the point of ethics. I contest each of these claims.

SummaryNone of the above should be viewed as a defence of the particular version of OOE currently popular. I have not advanced any proposals concerning what particular ends might be of such importance that they legitimately override her prima facie right to control the contents of her mind. I have suggested that an internal tension exists within CCE as sketched by Forster but even ‘empowerment’ was not assumed by me to successfully meet the onus; my point was merely that it (...) was to be more plausibly construed as an argument for a compulsory, outcome‐driven, rather than for a free, interest‐driven, curriculum. Whether it is right for Janey to be overruled or not is a matter for continuing discussion, a discussion that OOE challenges us to have. It is, however, a prospective dialogue that is pre‐empted by any assumption that, just because CCE is prevalent in primary schools, the task is to protect it from OOE's predatory threat. For all that Forster has provided argument to the contrary, OOE may be a reform; the enemy might not be ‘a narrow vision of the national good’ but a narrow conception of Janey's good; perhaps there are things more important about portions of learning than that Janey finds them to have ‘personal significance’. (shrink)

First published in 1998, this book is an investigation of the possibility of articulating a coherent thesis of truth relativism within first, a host correspondence theory of truth and second, a host coherence theory of truth. The type of relativism addressed in the book is what is sometimes called 'framework relativism' - that where truth is relativised to a framework of belief or conceptual scheme. A further restraint is that a global relativistic thesis is sought - one which is relativistic (...) about all truths. The book does not set itself the task of defending relativism but just that of seeking a coherent articulation of it. (shrink)

SummaryNone of the above should be viewed as a defence of the particular version of OOE currently popular. I have not advanced any proposals concerning what particular ends might be of such importance that they legitimately override her prima facie right to control the contents of her mind. I have suggested that an internal tension exists within CCE as sketched by Forster but even ‘empowerment’ was not assumed by me to successfully meet the onus; my point was merely that it (...) was to be more plausibly construed as an argument for a compulsory, outcome‐driven, rather than for a free, interest‐driven, curriculum. Whether it is right for Janey to be overruled or not is a matter for continuing discussion, a discussion that OOE challenges us to have. It is, however, a prospective dialogue that is pre‐empted by any assumption that, just because CCE is prevalent in primary schools, the task is to protect it from OOE's predatory threat. For all that Forster has provided argument to the contrary, OOE may be a reform; the enemy might not be ‘a narrow vision of the national good’ but a narrow conception of Janey's good; perhaps there are things more important about portions of learning than that Janey finds them to have ‘personal significance’. (shrink)

In his book, The Justification of Scientific Change, Carl Kordig claims that the radical meaning variance view of Feyerabend and others becomes ensnared in a self-referential paradox. The accusation fails because it rests upon a confusion of that view with its "counterparts" in other linguistic/theoretical contexts.

In his Quaestiones supra librum De Caelo et Mundo which are preserved in the manuscripts Vienna, Dominikanerkonvent 150/120, fols. 47ra-68va and Paris, Bibliothèque Mazarine 3493, fols. 95ra-136rb, Peter of Auvergne deals with the question of whether there is one world or whether there can be many worlds 24). Peter raises this question because Aristotle refutes the existence and possibility of a plurality of worlds in De Caelo I, 8-9. I shall first discuss the three sets of questions on (...) De Caelo attributed to Peter of Auvergne . In the second section I shall present the answers of authoritative ancient and medieval scholars on the problem of whether a plurality of worlds exists or is possible . Finally I shall examine Peter’s question and indicate its probable sources. (shrink)

Several medieval commentators on De caelo II, 7 investigate the question of whether local motion causes heat. I analyse the theories of Averroes, Albert the Great, Thomas Aquinas, Peter of Auvergne, John of Jandun, John Buridan and Nicole Oresme and two anonymous theories. Although all of these authors agree that local motion generates heat, each of them presents his own explanation of the heating effect of motion. Averroes, Thomas Aquinas, John of Jandun and John Buridan argue that motion is (...) the per se cause of heat. Their explanations of the heating effect of motion are based on metaphysical considerations such as the relation between a subject and its characteristics or perfections and the causal order in a genus. Albert the Great, Peter of Auvergne, Nicole Oresme and the anonymous commentators, on the contrary, defend the thesis that motion is the accidental cause of heat. Their explanations refer to physical processes caused by motion. (shrink)

Johanna Knapstein,1 Daniel Grimm,1 Marcus A Wörns,1 Peter R Galle,1 Hauke Lang,2 Tim Zimmermann111st Department of Internal Medicine, Johannes Gutenberg-University, Mainz, Germany; 2Department of General, Visceral and Transplantation Surgery, Johannes Gutenberg-University, Mainz, GermanyIntroduction: Hepatitis C virus reinfection occurs universally after liver transplantation, with accelerated cirrhosis rates of up to 30% within 5 years after liver transplantation. Dual antiviral therapy with pegylated interferon-2a and ribavirin only reaches sustained virological response rates of ~30% after liver transplantation. With the approval of (...) viral NS3/4A protease inhibitors telaprevir, boceprevir, and simeprevir and the NS5B polymerase inhibitor sofosbuvir, combination therapy offers new therapeutic options for HCV-infected patients, resulting in considerably higher sustained virological response rates in the nontransplant setting. Case presentation: We report three cases of TVR-based triple antiviral therapy in HCV genotype 1 reinfected patients after liver transplantation, of whom a 57-year-old Caucasian female and a 43-year-old Caucasian male were therapy naïve, and a 49-year-old Caucasian male patient was pretreated ineffectively. After 4 weeks of therapy, viral load decreased one to three log10 and became negative in weeks 6 to 8 in the therapy naïve patients. The pretreated patient showed a negative viral load in week 4. TVR was administered over 12 weeks, 750 mg thrice daily. Doses of immunosuppression with cyclosporine were reduced four to six fold. Initial peg-IFN and RBV doses ranged from 135–180 µg/week and 800–1,200 mg/day, according to the patient's body weight. Doses of peg-IFN and RBV were adapted to 90–135 µg/week and 400–800 mg/day after 2 to 12 weeks of protease inhibitor therapy. Dual therapy was continued for 36 weeks with total treatment duration of 48 weeks in the therapy naïve patients leading to a sustained virological response 12 weeks after the end of therapy. In the pretreated patient a breakthrough was detected in week 24 and therapy was discontinued. Overall, antiviral therapy was well tolerated. Side effects included dysgeusia and anemia leading to erythropoietin application and blood transfusions. Conclusion: This case series emphasizes that triple therapy with TVR is an efficient treatment for therapy naïve HCV genotype 1 reinfected patients after liver transplantation. But therapeutic options for pretreated patients require improvement. Keyword: cyclosporine, interferon, ribavirin, hepatitis C, protease inhibitor. (shrink)

In a previous article in _Philosophia, I claim that one can be a metaphysical relativist without being a truth relativist. One premise my argument for this claim relies on is (R2) truth relativism is inconsistent with the deflationary theory of truth. Peter Davson-Galle criticizes my argument for (R2), and also argues directly for the falsity of (R2). I try to show that Davson-Galle's effort to undermine (R2) founders due to his blurring the distinction between a taxonomy or (...) classification system on the one hand, and on the other, a conceptual framework in the sense use by truth relativists. (shrink)

Speech unfolds over time, and the cues for even a single phoneme are rarely available simultaneously. Consequently, to recognize a single phoneme, listeners must integrate material over several hundred milliseconds. Prior work contrasts two accounts: (a) a memory buffer account in which listeners accumulate auditory information in memory and only access higher level representations (i.e., lexical representations) when sufficient information has arrived; and (b) an immediate integration scheme in which lexical representations can be partially activated on the basis of early (...) cues and then updated when more information arises. These studies have uniformly shown evidence for immediate integration for a variety of phonetic distinctions. We attempted to extend this to fricatives, a class of speech sounds which requires not only temporal integration of asynchronous cues (the frication, followed by the formant transitions 150–350 ms later), but also integration across different frequency bands and compensation for contextual factors like coarticulation. Eye movements in the visual world paradigm showed clear evidence for a memory buffer. Results were replicated in five experiments, ruling out methodological factors and tying the release of the buffer to the onset of the vowel. These findings support a general auditory account for speech by suggesting that the acoustic nature of particular speech sounds may have large effects on how they are processed. It also has major implications for theories of auditory and speech perception by raising the possibility of an encapsulated memory buffer in early auditory processing. (shrink)

It is argued that causal understanding originates in experiences of acting on objects. Such experiences have consistent features that can be used as clues to causal identification and judgment. These are singular clues, meaning that they can be detected in single instances. A catalog of 14 singular clues is proposed. The clues function as heuristics for generating causal judgments under uncertainty and are a pervasive source of bias in causal judgment. More sophisticated clues such as mechanism clues and repeated interventions (...) are derived from the 14. Research on the use of empirical information and conditional probabilities to identify causes has used scenarios in which several of the clues are present, and the use of empirical association information for causal judgment depends on the presence of singular clues. It is the singular clues and their origin that are basic to causal understanding, not multiple instance clues such as empirical association, contingency, and conditional probabilities. (shrink)

Berkeley’s likeness principle is the claim that “an idea can be like nothing but an idea”. The likeness principle is intended to undermine representationalism: the view (that Berkeley attributes to thinkers like Descartes and Locke) that all human knowledge is mediated by ideas in the mind which represent material objects. Yet, Berkeley appears to leave the likeness principle unargued for. This has led to several attempts to explain why Berkeley accepts it. In contrast to ‘metaphysical’ and ‘epistemological’ interpretations available in (...) the literature, in this paper I defend a ‘conceptual’ interpretation. I argue that Berkeley accepts the likeness principle on the basis of (i) his commitment to the transparency of ideas, and (ii) his account of resemblance which he sets out in his works on vision. Thus, I provide an explanation for Berkeley’s reasons for accepting the likeness principle which, appropriately, focuses on his views concerning ideas and likeness. (shrink)