In one of his key publications on the harmful dysfunction analysis of mental disorder (HDA), Jerome Wakefield acknowledged that he has “explored the value element in disorder less thoroughly than the factual element. This is in part because the factual component poses more of a problem for inferences about disorder and in part because the nature of values is such that it requires separate consideration” (Wakefield 1992, 384). More than twenty years have passed since this remark, and yet a thorough (...) consideration of the value component in Wakefield’s HDA is still lacking. Quite a few contributions to this volume promise to change that situation, and ours is one of these. In this contribution, we will analyze the harm or value component and argue that Wakefield’s dealing with it is so problematic that it undermines, at least indirectly, the viability of the HDA. In the first section, we explore Wakefield’s emphasis on the subjective nature of harm and his exclusive focus on social values. The second section is devoted to an analysis of Wakefield’s examples of conditions that are dysfunctional but harmless (fused toes, albinism, reversal of the heart, dyslexia in illiterate societies, etc.). We argue that these examples are quite problematic because they do not exemplify what they are supposed to exemplify. In the third section, we show how these two problems are connected: Wakefield uses the harmfulness of a condition as an implicit criterion to distinguish normal variation from dysfunction. In doing so, he blurs the distinction between the harm component and the dysfunction component, even though this distinction is central to his HDA. (shrink)

Lionel Penrose (1898–1972) was an important leader during the mid-20th century decline of eugenics and the development of modern medical genetics. However, historians have paid little attention to his radical theoretical challenges to mainline eugenic concepts of mental disease. Working from a classification system developed with his colleague, E. O. Lewis, Penrose developed a statistically sophisticated and clinically grounded refutation of the popular position that low intelligence is inherently a disease state. In the early 1930s, Penrose advocated dividing “mental defect” (...) (low intelligence) into two categories: “pathological mental defect,” which is a disease state that can be traced to a distinct genetic or environmental cause, and “subcultural mental defect,” which is not an inherent disease state, but rather a statistically necessary manifestation of human variation in intelligence. I explore the historical context and theoretical import of this contribution, discussing its rejection of typological thinking and noting that it preceded Theodosius Dobzhansky’s better-known defense of human diversity. I illustrate the importance of Penrose’s contribution with a discussion of an analogous situation in contemporary medicine, the controversial practice of using human growth hormone injections to treat “idiopathic short stature” (mere diminutive height, with no distinct cause). I show how Penrose’s contributions to understanding human variation make such treatments appear quite misguided. (shrink)

This article draws attention to several common mistakes in thinking about biomedical enhancement, mistakes that are made even by some supporters of enhancement. We illustrate these mistakes by examining objections that John Harris has recently raised against the use of pharmacological interventions to directly modulate moral decision-making. We then apply these lessons to other influential figures in the debate about enhancement. One upshot of our argument is that many considerations presented as powerful objections to enhancement are really strong considerations in (...) favour of biomedical enhancement, just in a different direction. Another upshot is that it is unfortunate that much of the current debate focuses on interventions that will radically transform normal human capacities. Such interventions are unlikely to be available in the near future, and may not even be feasible. But our argument shows that the enhancement project can still have a radical impact on human life even if biomedical enhancement operated entirely within the normal human range. (shrink)

I offer a new objectivist theory of the contents of color language and color experience, intended especially as an account of what normal intersubjective variation in color perception and classification shows about those contents. First I explain an abstract account of the contents of color and other gradable adjectives; on the account, these contents are certain objective properties constituted in part by contextually intended standards of application, which are in turn values in the dimensions of variation associated (...) with the adjectives. Then I propose an explanation of normal variations in linguistic color classification; these are postulated to be effects of differences in intended standards for the color adjectives appearing in the classifying predicates. Next, I consider a potential objection to this explanation, based on the suggestion that contextual content should be more accessible than the explanation predicts. In reply, I point out that contextual content is occasionally opaque to unsophisticated reflection. Finally, I present a companion account of the contents of color experiences on which these represent an object as lying on certain salient intervals in the chromatic dimensions, and I show how the account accommodates intersubjective variation in color perception. (shrink)

Women’s preferences for several male traits, including voices, change over the menstrual cycle, but the proximate causes of these changes are unknown. This paper explores relationships between levels of estradiol, progesterone, luteinizing hormone, follicle stimulating hormone, prolactin, and testosterone (estimated using menstrual cycle information) and women’s preferences for male vocal masculinity in normally cycling and hormonally contracepting heterosexual females. Preferences for vocal masculinity decreased with predicted progesterone levels and increased with predicted prolactin levels in normally cycling—but not hormonally contracepting—women. Adaptive (...) explanations for menstrual variation in women’s preferences for masculine traits are discussed and evaluated in light of these findings. (shrink)

High‐throughput genomic technologies are revolutionizing human genetics. So far the focus has been on the 1.5% of the genome, which is coding, in spite of the fact that the great majority of genomic variants fall outside the coding regions. Recent efforts to annotate the non‐coding sequence show that over 80% of the genome is biochemically active. The genome is divided into regulatory domains consisting of sequence regions that enhance and/or silence the expression of nearby genes and are, in some cases, (...) separated by boundaries with insulator activity. In this paper, we review the recent advances in the identification of variations that influence gene regulation and their consequences for human disease. We hypothesize that structural variations outside of the coding genome can interfere with normal gene regulation by disrupting the regulatory landscape. Therefore, the regulatory landscape of the genome has also to be taken into consideration when investigating the pathology of human disease. (shrink)

The dichotomy between the conceptual and the empirical is part of common sense, yet its organizing force also extends to intellectual life more generally, including the disciplinary life of science and technology studies. This article problematizes this dichotomy as it operates in contemporary STS discussions, arguing instead that the conceptual and the empirical form unstable hybrids. Beginning with a discussion of the “discontents” with which the dominant theory methods packages in STS are viewed, it is suggested that STS has entered (...) a phase resembling Kuhnian normal science. Based on a discussion of the making of cognitive dissonance theory, it is then argued conceptual–empirical mixtures are unavoidable in actual research practice. This situation can be taken as an encouragement for more sustained exploration of conceptual–empirical relations and their inventive potentials. Invoking Deleuze and Guattari’s notion of “continuous variation,” the article concludes that STS as a discipline is well served by promoting an ethos of empirical and conceptual experimentation. (shrink)

This paper aims to clarify the consequences of new scientific and philosophical approaches for the practical-theoretical framework of modern developmental biology. I highlight normal development, and the instructive-permissive distinction, as key parts of this framework which shape how variation is conceptualised and managed. Furthermore, I establish the different dimensions of biological variation: the units, temporality and mode of variation. Using the analytical frame established by this, I interpret a selection of examples as challenges to the instructive-permissive (...) distinction. These examples include the phenomena of developmental plasticity and transdifferentiation, the role of the microbiome in development, and new methodological approaches to standardisation and the assessment of causes. Furthermore, I argue that investigations into organismal development should investigate the effects of a wider range of kinds of variation including variation in the units, modes and temporalities of development. I close by examining various possible opportunities for producing and using normal development free of the assumptions of the instructive-permissive distinction. These opportunities are afforded by recent developments, which include new ways of producing standards incorporating more natural variation and being based on function rather than structure, and the ability to produce, store, and process large quantities of data. (shrink)

The article is the text of a lecture given at the Faculty of the Humanities, March 2001. It argues that one implication of recent advances in the sciences of life may be that the binary opposition of the normal and the pathological is put into question. Canguilheim’s distinction between vital and social norms is challenged and superseded by a Foucauldian genealogical approach to programs for the government of individuals, and the norms of life that emerged in the nineteenth and (...) twentieth centuries are argued to be fundamentally social. Viewing genetics, biopsychiatry, and the commercialisation of drug development and biomedicine, the author argues that the logic of normalisation is loosing its hold, and being replaced by strategies for the continuous molecular management of variation, the modulation of susceptibilities, and the capitalisation of life itself. (shrink)

Qu'est-ce qu'un enseignement? Une pensée? Qu'autorisent-ils? À la suite de Claire Brunet, Sandra Laugier et Frédérique Ildefonse qui dirigent ce volume, d'anciens étudiants, aujourd'hui chercheurs renommés ou plus discrets, creusent à travers le sillon de leur discipline ce que leur a permis l'enseignement de leur maître commune à l'École normale supérieure. Les amitiés intellectuelles s'y joignent. Ce que l'on appelle communément communication dans le monde académique devient texte. Tous, en creux, décrivent l'influence d'un enseignement, la liberté qu'il permet à des (...) esprits pour s'épanouir et nous laissent découvrir un portrait intellectuel d'une grande originalité. La pensée de Claude Imbert, philosophe, logicienne, longtemps directrice du département de philosophie de la rue d'Ulm, n'a pas les honneurs médiatiques français en sus des "académiques" d'usage. S'y prêterait-elle? Pourtant, la philosophe française est depuis plus de vingt ans lue, reçue et écoutée dans les universités du monde entier, des Etats-Unis à la Chine en passant par l'Amérique du Sud. Tous les textes rassemblés ici, comme autant de variations, sans jamais le dire, souhaitent contribuer à la reconnaissance de l'oeuvre. Un inédit "Ne rien oublier et tout apprendre" de la philosophe et un texte de Pascalle Monnier, écrivain, accompagnent le volume."--Page 4 of cover. (shrink)

This article analyses the slippery notions of the normal and normality in select works of Richard von Krafft-Ebing (1840–1902) and Sigmund Freud (1856–1939) and argues that homosexuality became a ‘boundary object’ between the normal and the abnormal in their works. Constructing homosexuality as ‘normal enough’ provided these two key thinkers of the fin de siècle with an opportunity to challenge societal and medical norms: Krafft-Ebing did this through mapping perversions; Freud, by challenging perceived norms about sexual development (...) more broadly. The article submits that the scientific logic presented in Krafft-Ebing’s seminal case study compilation Psychopathia Sexualis and Freud’s early theoretical writings and cases, including Three Essays on the Theory of Sexuality (1905), was itself haunted by notions of norms and the normal that were not always easy to resolve, and sometimes involved a certain amount of inspired conjecture on the part of both thinkers in order to develop and validate their differing tripartite models of normality. Krafft-Ebing imagined homosexuality as a variation of the normal by generalizing a gay male experience. He also recorded the obstreperous cases of homosexual women based largely inside the clinic but by and large ignored this evidence. Freud inextricably bound homosexuality to normality (and vice versa) by redefining homosexuals as a group to include individuals with unconscious same-sex desire. Doing so allowed him to conceptualize the fear of homosexuality as crucial in the formation of neurosis and psychosis, and at the same time put him at odds with relevant early identity politics. (shrink)

The Human Genome Project (HGP) has been criticised from an evolutionary perspective for three reasons: completely ignoring genetic variation; improperly treating either all or some genetic variation as deviation from a norm; and mistakenly seeking to define species in terms of essential properties possessed by all and only member organisms. The first claim is unfounded; the second and third claims are more on target. Nevertheless, it is a mistake to use the typological-population distinction to oppose molecular genetics and (...) evolutionary genetics in order to characterise HGP mapping and sequencing aims, especially the production of a DNA reference sequence, as 'anti-evolutionary' and 'pre-Darwinian.' These aims are consistent with certain strands in twentieth-century evolutionary thought: Muller's classical theory, Kimura's neutral and 'effectively neutral' theories, and, to a lesser extent, Dobzhansky's balance theory of the genetic structure of natural populations. In practice, population-based approaches to human genetic variation are similarly vulnerable to charges of 'typological' and 'essentialist' thinking in their treatment of genetic variation as deviation. This means that the Human Genome Diversity Initiative will not provide a population-based panacea for an overly typological HGP, as its proponents contend. Substituting related, and less rhetorically-charged, conceptual, empirical, and metaphysical distinctions for the typological-population distinction furnishes a better way to assess the concept of the normal genome from an evolutionary perspective. (shrink)

The aim of this study was to test red - green dichromats' ability to discriminate between illuminant and surface-reflectance changes in natural scenes. Stimuli were simulations of natural scenes presented on a colour monitor with 10-bit resolution per gun. The natural scenes were obtained with a fast hyperspectral imaging system. Six different scenes (including rocks, foliage, and buildings) were tested. In each trial, two images were presented in sequence, each for 1 s, with no interval. The images differed in the (...) phase of daylight on the scene: first with correlated colour temperature 25 000 K, then 6 700 K. The spectral reflectance of a region in the second image was changed randomly, consistent with a local change in daylight. The observer's task was to decide whether a particular surface in the successive images was the same (pure illuminant change) or different (illuminant change with a surface-reflectance change). The performance of four deuteranopes and five protanopes varied considerably across the scenes tested, with mean colour constancy indices (± 1 SEM) of 0.48 (± 0.13) and 0.19 (± 0.10), respectively (1.0 representing ideal performance). Deuteranopes seemed less disadvantaged than protanopes, performing close to normal with some scenes. (shrink)

An important challenge to color objectivists, who hold that statements concerning color are made true or false by objective facts, is the argument from interpersonal variation in where normal observers locate the unique hues. Recently, an attractive objectivist response to the argument has been proposed that draws on the semantics of gradable adjectives and which does not require defending the idea that there is a single correct location for each of the unique hues Noûs 50: 3–40),. In ), (...) I argued that the recent objectivist response doesn’t apply to comparative occurrences of color adjectives, so a revised, comparative, version of the argument from interpersonal variation remains a powerful objection to certain types of objectivism. In this paper, I address several unsatisfactory objectivist replies to the comparative version of the argument from interpersonal variation, and offer what I think is a more plausible objectivist reply to the comparative argument from interpersonal variation. (shrink)

Reviews in Common Knowledge generally seek to be more cool and edgy than their subjects, an impossibility in this case. Ording takes a mathematical statement and reaches it in ninety-nine different ways. This book is quite literally a page-turner: most of the arguments take the recto page, with comments on their verso. One keeps cycling back and forth between the mathematical inventiveness of the recto and the philosophical elegance of the verso. The ambition is huge—to construct a mathematical counterpart to (...) Queneau's masterpiece Exercises de Style—and, remarkably, this ambition is fulfilled.It is interesting that Queneau's variations are much closer to each other than Ording's are. Queneau often feels free to provide, as a variation, the very same text with a fundamentally grammatical transformation (switching the order of the descriptions, changing their tenses, and so forth). Most of the time, Ording feels obliged to come up with a significantly different argument. Indeed, his fixed core is less constraining: instead of following the same narrative arc in different forms, he merely has to reach the same endpoint. Ording's book is rather like ninety-nine different jokes leading to the same punch line. To be clear: it is perfectly possible to produce the precise same narrative arc, in mathematics, via different forms. Switching the order is a normal way in which such exercises in mathematical style are actually produced (mathematicians do have to decide whether to write “P, therefore Q” or to write “Q, since P”). Evidently, Ording felt that producing many such purely grammatical and formal transformations would feel tedious, which is fair enough but is not precisely a contrast between mathematics and literature. Queneau's variations are, indeed, tedious; delightfully tedious; delightful in their tediousness. Joyce as a tasting menu. Some readers of modernist literature can take delight in a certain tediousness, but Ording has no illusions concerning the audience for mathematics, and, to make his own variations appealing, he had to make them much more interesting than Queneau's. The result is brilliant and should be read by anyone interested in mathematics, literature, and their many parallels and variations. (shrink)

BackgroundAntipsychotic-induced weight gain is a contributing factor in the reduced life expectancy reported amongst people with psychotic disorders. CYP2D6 is a liver enzyme involved in the metabolism of many commonly used antipsychotic medications. We investigated if CYP2D6 genetic variation influenced weight or BMI among people taking antipsychotic treatment.MethodsWe conducted a systematic review and a random effects meta-analysis of publications in Pubmed, Embase, PsychInfo, and CENTRAAL that had BMI and/or weight measurements of patients on long-term antipsychotics by their CYP2D6-defined metabolic (...) groups.ResultsTwelve studies were included in the systematic review. All cohort studies suggested that the presence of reduced-function or non-functional alleles for CYP2D6 was associated with greater antipsychotic-induced weight gain, whereas most cross-sectional studies did not find any significant associations. Seventeen studies were included in the meta-analysis with clinical data of 2,041 patients, including 93 poor metabolizers, 633 intermediate metabolizers, 1,272 normal metabolizers, and 30 UMs. Overall, we did not find associations in any of the comparisons made. The estimated pooled standardized differences for the following comparisons were PM versus NM; weight = –0.07, BMI = 0.40. IM versus NM; weight = 0.09 and BMI = 0.09. UM versus EM; weight = 0.01 and BMI = –0.08.ConclusionOur systematic review of cohort studies suggested that CYP2D6 poor metabolizers have higher BMI than normal metabolizers, but the data of cross-sectional studies and the meta-analysis did not show this association. Although our review and meta-analysis constitutes one of the largest studies with comprehensively genotyped samples, the literature is still limited by small numbers of participants with genetic variants resulting in poor or UMs status. We need further studies with larger numbers of extreme metabolizers to establish its clinical utility in antipsychotic treatment. CYP2D6 is a key gene for personalized prescribing in mental health. (shrink)

This article is composed of three parts. In the first part of the article I take up a question raised by Susanna Siegel (Philosophical Review 115: 355–388, 2006a). Siegel has argued that subjects have the following anticipation: (PC) If S substantially changes her perspective on o, her visual phenomenology will change as a result of this change. She has left it an open question as to whether subjects anticipate a specific kind of change. I take up this question and answer (...) it in the affirmative. By appealing to a widely held view of perceptual content, the view that we represent ‘factual’ properties in perception, I argue that (PC) can be refined as follows: (PC’) If S substantially changes her perspective on o, her visual phenomenology will present different views of o’s factual properties. In the second part of the article I argue that (PC’) implies that there are cases in which normal perceivers have different perceptual content under identical viewing conditions. The differences in perceptual content are due to differences in the determinacy of visual anticipation. I draw the conclusion that perceptual content is rich in the sense that it includes a unique contribution from individual perceivers. In the final part of the article, I discuss some open issues regarding the way in which (PC’) relates to the personal/sub-personal distinction, empirical models, and the distinction between perception and cognition. (shrink)

There exists a significant disparity within society between individuals in terms of intelligence. While intelligence varies naturally throughout society, the extent to which this impacts on the life opportunities it affords to each individual is greatly undervalued. Intelligence appears to have a prominent effect over a broad range of social and economic life outcomes. Many key determinants of well-being correlate highly with the results of IQ tests, and other measures of intelligence, and an IQ of 75 is generally accepted as (...) the most important threshold in modern life. The ability to enhance our cognitive capacities offers an exciting opportunity to correct disabling natural variation and inequality in intelligence. Pharmaceutical cognitive enhancers, such as modafinil and methylphenidate, have been shown to have the capacity to enhance cognition in normal, healthy individuals. Perhaps of most relevance is the presence of an ‘inverted U effect’ for most pharmaceutical cognitive enhancers, whereby the degree of enhancement increases as intelligence levels deviate further below the mean. Although enhancement, including cognitive enhancement, has been much debated recently, we argue that there are egalitarian reasons to enhance individuals with low but normal intelligence. Under egalitarianism, cognitive enhancement has the potential to reduce opportunity inequality and contribute to relative income and welfare equality in the lower, normal intelligence subgroup. Cognitive enhancement use is justifiable under prioritarianism through various means of distribution; selective access to the lower, normal intelligence subgroup, universal access, or paradoxically through access primarily to the average and above average intelligence subgroups. Similarly, an aggregate increase in social well-being is achieved through similar means of distribution under utilitarianism. In addition, the use of cognitive enhancement within the lower, normal intelligence subgroup negates, or at the very least minimises, several common objections to cognitive enhancement. Subsequently, this paper demonstrates that there is a compelling case for cognitive enhancement use in individuals with lower, normal intelligence. (shrink)

THE PURPOSE of this discussion is a double one. I want to show, in the first place, how a Platonic attempt to describe the structures of time that we encounter in becoming presupposes a reference to the more stable structures of the realm of being. The result of this presupposition is a temptation to substitute the more stable forms for the less intellectually congenial ones, thus turning "time" into a dimension of space or a series of arithmetical "units." This can (...) only be corrected by reversing normal Platonic "explanatory direction" and generating the appearances of time on the several levels of the Platonic cosmos by adding increments of nonbeing and irregularity to the pure forms of arithmetic and geometry. In the second place, this Platonic generation shows exactly why an appeal to the structure of language is of no help whatever in determining the nature of time, real or apparent. Because the attempt is so often made to start with language structure as a key to time, I consider my demonstration that this is misguided an important one. I concede that my discussion of the issue is not indifferent to system-frames, but radically Platonic. The reason is in part the elegance with which the Platonic system locates talking about time on the level of eikasia, the realm of shadows on the wall of Plato’s Cave. (shrink)

In this article, I will discuss the Husserlian phenomenology of animality, by focusing on several texts of the 1920s in which the animal is determined as an abnormal variation of the human being. My aim is to address the question of the abnormality of the animal by reintegrating it in its original context, which is Husserl’s theory of normality. I will sketch the general framework of this theory, its articulations and strata, in order to eventually raise some paradoxical issues, (...) specifically in relation to how the question of animality is interpreted through the couple normality/abnormality. (shrink)

Idealization is a reasoning strategy that biologists use to describe, model and explain that purposefully departs from features known to be present in nature. Similar to other strategies of scientific reasoning, idealization combines distinctive strengths alongside of latent weaknesses. The study of ontogeny in model organisms is usually executed by establishing a set of normal stages for embryonic development, which enables researchers in different laboratory contexts to have standardized comparisons of experimental results. Normal stages are a form of (...) idealization because they intentionally ignore known variation in development, including variation associated with phenotypic plasticity (e.g. via strict control of environmental variables). This is a tension between the phenomenon of plasticity and the practice of staging that has consequences for evolutionary developmental investigation because variation is conceptually removed as a part of rendering model organisms experimentally tractable. Two compensatory tactics for mitigating these consequences are discussed: employing a diversity of model organisms and adopting alternative periodizations. (shrink)

Abstract: -/- We present a teaching activity, whose aim is to enhance students’ understanding of color perception by introducing them to intersubjective color variations among normal perceivers. The approach can be used in different disciplines, including biology, philosophy, psychology, physics, or statistics, for different purposes and with college students having various levels of sophistication and scientific training.

DNA copy number variation (CNV) represents a considerable source of human genetic diversity. Recently,1 a global map of copy number variation in the human genome has been drawn up which reveals not only the ubiquity but also the complexity of this type of variation. Thus, two human genomes may differ by more than 20 Mb and it is likely that the full extent of CNV still remains to be discovered. Nearly 3000 genes are associated with CNV. This (...) high degree of variability with regard to gene copy number between two individuals challenges definitions of normality. Many CNVs are located in regions of complex genomic structure and this currently limits the extent to which these variants can be genotyped by using tagging SNPs. However, some CNVs are already amenable to genome‐wide association studies so that their influence on human phenotypic diversity and disease susceptibility may soon be determined. BioEssays 29:311–313, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

This study tested the two main neurocognitive models of dreaming by using cognitive data elicited from REM sleep in normals and narcoleptics. The two models were the ''activation-only'' view which holds that, in the context of sleep, overall activation of the brain is sufficient for consciousness to proceed in the manner of dreaming (e.g., Antrobus, 1991; Foulkes, 1993; Vogel, 1978); and the Activation, Input source, Modulation (AIM model), which predicts that not only brain activation level but also neurochemical modulatory systems (...) exert widespread effects upon dreaming (Hobson & McCarley, 1977; Hobson, Pace-Schott, & Stickgold, 2000). Mental activity was studied in nocturnal REM in 15 narcoleptics and 9 normal healthy persons and in REM at the onset of daytime naps and nighttime sleep (SOREM) in narcoleptics. The study was performed in the subjects' homes, using instrumental awakenings and ambulatory polysomnographic techniques, and focused upon visual vividness, mentation report length, improbable and discontinuous bizarre features, and reflective consciousness. Within each subject group, most cognitive variables tended to fluctuate in line with expected variations in circadian activation level. When comparing the cognitive variables between the two groups, reflective consciousness was clearly highest in narcoleptics, whereas improbabilities and discontinuities were lower, with mentation report length and visual vividness differing less between the groups. These findings are consistent with the AIM model of sleep mentation, but not with the activation-only model. (shrink)

The theory of psychosis and autism as diametrical disorders offers a tractable and testable view of normal and abnormal human cognitive variation as a function of opposing traits grouped by their selection for maternal and paternal reproductive fitness. The theory could be usefully rooted and developed with reference to the lower-level perceptual and attentional phenomena from which social cognitive modules are developmentally refined.

Neurodiversity has remained a controversial concept over the last decade. In its broadest sense the concept of neurodiversity regards atypical neurological development as a normal human difference. The neurodiversity claim contains at least two different aspects. The first aspect is that autism, among other neurological conditions, is first and foremost a natural variation. The other aspect is about conferring rights and in particular value to the neurodiversity condition, demanding recognition and acceptance. Autism can be seen as a natural (...) variation on par with for example homosexuality. The broad version of the neurodiversity claim, covering low-functioning as well as high-functioning autism, is problematic. Only a narrow conception of neurodiversity, referring exclusively to high-functioning autists, is reasonable. We will discuss the effects of DSM categorization and the medical model for high functioning autists. After a discussion of autism as a culture we will analyze various possible strategies for the neurodiversity movement to claim extra resources for autists as members of an underprivileged culture without being labelled disabled or as having a disorder. We will discuss their vulnerable status as a group and what obligation that confers on the majority of neurotypicals. (shrink)

L’étude des troubles de la voix et de la parole est sortie du cadre de la recherche clinique. Par l’observation des dysfonctionnements, les chercheurs non cliniciens confrontent les résultats de leur recherche établis sur des corpus de parole « normale » à des situations de dysfonctionnement. Le défi est immense car le cadre « pathologique » induit une variation considérable dans ses manifestations de surface. Toute généralisation à une population clinique particulière nécessite l’observation d’un grand nombre de patients du (...) fait de la très forte variation interindividuelle. Il est donc important de capitaliser et mutualiser les enregistrements existants. Or pour être utilisables, ces enregistrements doivent répondre à de fortes exigences. Le maillon faible reste la normalisation et la structuration des données sur les locuteurs et leurs productions langagières. Concrètement, si les données sonores sont souvent accessibles, elles ne présentent au final aucun intérêt si les liens entre les enregistrements et les caractéristiques cliniques du locuteur sont rompus ou erronés. L’objectif de ce travail est de présenter différentes actions de terrain et de proposer des recommandations pour la structuration des données sonores, physiologiques et cliniques dans le cas de corpus de parole issue de patients atteints de troubles de la voix et de la parole. (shrink)

This article concerns the treatment of propositional quantification in a framework of labelled natural deduction for modal logic developed by Basin, Matthews and Viganò. We provide a detailed analysis of a basic calculus that can be used for a proof-theoretic rendering of minimal normal multimodal systems with quantification over stable domains of propositions. Furthermore, we consider variations of the basic calculus obtained via relational theories and domain theories allowing for quantification over possibly unstable domains of propositions. The main result (...) of the article is that fragments of the labelled calculi not exploiting reductio ad absurdum enjoy the Church–Rosser property and the strong normalization property; such result is obtained by combining Girard’s method of reducibility candidates and labelled languages of lambda calculus codifying the structure of modal proofs. (shrink)

We agree with the critique of the Residual Normality assumption. Moreover, we challenge monolithic views of functional normality. Throughout life, development and adaptation require variations in cortical functional circuitry within and across individuals. We propose the principle of “coconstructed functionality” which maintains that brain-behavior functional correspondences are dynamically coproduced by neurobiological, experiential, and contextual processes.

I begin with my impressions of a narrative of redemption that is caught up in the formation of new environmental, social, and political aspirations for the aftermath of the COVID-19 pandemic. I then reflect on, first, pre-pandemic scholarship on “biosecurity” and, second, taking up a variation of the syndemic approach to understanding the COVID-19 pandemic. I end by arguing that we should not expect to live with “new normals” for living in a post-COVID-19 world that leaves intact “old normals” (...) that have historically contributed to the rise of anthropogenic environmental harms and inegalitarian social arrangements in the world today. (shrink)

Structuring Sense explores the difference between words however defined and structures however constructed. It sets out to demonstrate over three volumes, of which this is the second, that the explanation of linguistic competence should be shifted from lexical entry to syntactic structure, from memory of words to manipulation of rules. Its reformulation of how grammar and lexicon interact has profound implications for linguistic, philosophical, and psychological theories about human mind and language. Hagit Borer departs from both language specific constructional approaches (...) and lexicalist approaches to argue that universal hierarchical structures determine interpretation, and that language variation emerges from the morphological and phonological properties of inflectional material. The Normal Course of Events applies this radical approach to event structure. Integrating research results in syntax, semantics, and morphology, the author shows that argument structure is based on the syntactic realization of semantic event units. The topics she addresses include the structure of internal arguments and of telic and atelic interpretations, accusative and partitive case, perfective and imperfective marking, the unaccusative-unergative distinction, existential interpretation and post-verbal subjects, and resultative constructions. The languages discussed include English, Catalan, Finnish, Hebrew, Czech, Polish, Russian, and Spanish. (shrink)

From the end of the First World War, a broad discussion took place within the framework of the revived German constitutional teaching on the question of the physical normality of man. The founder of the so-called statistical concept of normality, which preceded the still widespread normal (reference) interval concept, is H. Rautmann, who gave it the character of a tool for discriminating between health and disease. Among some of his successors (Bauer, Borchardt, Günther), however, it was considered more a (...) means of establishing a type, without supposing any precise relation between the frequency of a character in the population and the probability of the occurrence of disease. The concept of a statistical norm as a certain region of the variation range of a character determined by the parameters of Gaussian distribution was criticized both by the supporters of the ideal norm (Hildebrandt) and those who were in favour of a ‘personal’ norm (Grote). The underlying motifs of these three conceptions of normality influenced German constitutional doctrine until after the end of the Second World War, but without a satisfactory solution to the diagnosis of physical normality being found. Since the 1950s, world medicine has moved more and more in the direction of prevention, with the emphasis on a study of individual dispositions to disease and its precursors. In this connection a new view of health has gained importance whereby it is considered a smoothly gradated condition, not sharply distinguished from disease (‘continual’ model of health and disease as opposed to the previous ‘alternative’ model). The purpose of diagnostic characters is no longer merely to place patients in clearly defined categories as healthy or affected by one disease or another, but has taken on the function of indices of the disposition to disease among those who exhibit ‘gross normality’. Discrimination between the alternative and continuous models allows a clarification to be made of the sources of the confusion in which the pre-war concept of statistical normality had found itself. Today many exceptions are known to the rule that the functional optimum lies in the region of the population mean, both for the population as a whole and for individuals; and immense variability has been found in the manner in which individuals in the population attain health. Thus a distinction between health and disease by statistical means alone (such as establishing some sort of species design) is not possible at all. The ideal of a personal norm is pursued today through the concept of a multivariate norm backed up by modern data processing methods, though it was anticipated in principle by Kaup even in the 1920s. CiteULike Connotea Del.icio.us What's this? (shrink)

Philologus, founded in 1846, is one of the oldest and most respected periodicals in the field of Classics. It publishes articles on Greek and Latin literature, historiography, philosophy, history of religion, linguistics, reception, and the history of scholarship. The journal aims to contribute to our understanding of Greco-Roman culture and its lasting influence on European civilization. The journal Philologus, conceived as a forum for discussion among different methodological approaches to the study of ancient texts and their reception, publishes original scholarly (...) contributions with a strong international focus. Publications languages are: German, English, Italian, French. As of 2014 the publication of supplementary volumes will be resumed. The series Philologus. Supplemente / Philologus. Supplementary Volumes will publish monographs and edited volumes pertaining to all aspects of the study of ancient literature and its reception, with a special focus on topics concerning literary theory, philosophy and the history of scholarship from an interdisciplinary perspective. (shrink)

We study the problem of minimizing $\int _\Omega F)\, dx \;$ over the functions $u\in W^{1,1}$ that assume given boundary values $\phi $ on $\Gamma := \partial \Omega $. The lagrangian $F$ and the domain $\Omega $ are assumed convex. A new type of hypothesis on the boundary function $\phi $ is introduced: the lower bounded slope condition. This condition, which is less restrictive than the familiar bounded slope condition of Hartman, Nirenberg and Stampacchia, allows us to extend the classical (...) Hilbert-Haar regularity theory to the case of semiconvex boundary data. We prove in particular that the solution is locally Lipschitz in $\Omega $. In certain cases, as when $\Gamma $ is a polyhedron or else of class $C^{1,1}$, we obtain in addition a global Hölder condition on $\,\overline{\!\,\Omega }$. (shrink)

We show that in quantum logic of closed subspaces of Hilbert space one cannot substitute quantum operations for classical (standard Hilbert space) ones and treat them as primitive operations. We consider two possible ways of such a substitution and arrive at operation algebras that are not lattices what proves the claim. We devise algorithms and programs which write down any two-variable expression in an orthomodular lattice by means of classical and quantum operations in an identical form. Our results show that (...) lattice structure and classical operations uniquely determine quantum logic underlying Hilbert space. As a consequence of our result, recent proposals for a deduction theorem with quantum operations in an orthomodular lattice as well as a, substitution of quantum operations for the usual standard Hilbert space ones in quantum logic prove to be misleading. Quantum computer quantum logic is also discussed. (shrink)