This paper presents the design, simulation, and experimental verification of the fractional-order multiscroll Lü chaotic system. We base them on op-amp-based approximations of fractional-order integrators and saturated series of nonlinear functions. The integrators are first-order active realizations tuned to reduce the inaccuracy of the frequency response. By an exponential curve fitting, we got a convenient design equation for realizing fractional-order integrators of orders from 0.1 to 0.95. The results include simulations in SPICE of the mathematical description (...) and the electronic implementation and experimental measurements that confirm them. Monte Carlo and sensitivity tests revealed a robust realization. Contrary to its passive counterparts, the suggested realizations significantly reduce design and implementation efforts by favoring resistors and capacitors with commercial values and reducing hardware requirements. (shrink)

Every account of moral responsibility has conditions that distinguish between the consequences, actions, or traits that warrant praise or blame and those that do not. One intuitive condition is that praiseworthiness and blameworthiness cannot be affected by luck, that is, by factors beyond the agent’s control. Several philosophers build their accounts of moral responsibility on this luck-free condition, and we may call their views Luck-Free Moral Responsibility (LFMR). I offer moral and metaphysical arguments against LFMR. First, I maintain that considerations (...) of fairness that often motivate LFMR do not require its adoption. Second, I contend that LFMR has counterintuitive implications for the nature and scope of praiseworthiness and blameworthiness and that LFMR is vulnerable to a reductio ad absurdum. Third, I state some common reasons for thinking that LFMR’s commitment to true counterfactuals of libertarian freedom is problematic, and I argue that if there are no such true counterfactuals and if LFMR is true, a person is praiseworthy and blameworthy at most for a tiny fraction of her actions. Fourth, I argue that proponents of LFMR cannot escape this skeptical cost by appealing to a different kind of counterfactual of freedom. Fifth, I develop an anti-skeptical motivation to affirm the idea that luck can affect moral responsibility. (shrink)

Whether agents are morally responsible for their need for scarce resources is a difficult and fraught issue. In this chapter, I aim to explore some unappreciated difficulties for the attribution of moral responsibility for needs that arise from the fact that in typical cases, ill-health arises from lifestyle: not, that is, from one bad decision, but from a long-term pattern of actions. First, I hope to build on Brown and Savulescu’s (2019) programmatic exploration of what they call the diachronic condition (...) on moral responsibility for ill-health. I will show that the diachronic condition fractionates in multiple ways, depending on how ill-health is caused as well as on the theory of moral responsibility at issue. Second, I aim to show that it is much harder to satisfy the diachronic condition on moral responsibility for ill-health than is widely assumed. I will argue that we usually cannot be confident that a particular agent (or a class of agents: say alcoholics) is responsible for their ill-health, and that—I will suggest—should make us hesitant to ascribe responsibility to them. Finally, I turn to an assessment of responsibility as a tie-breaker between patients. We might think that we need something far short of a reasonable doubt standard for responsibility to serve in this role. Perhaps a balance of probabilities standard can justify our using it. I will argue that even if we have the right to confidence on this standard, this may not be enough for responsibility to serve as a tie-breaker between agents in the context of the allocation of scarce resources. (shrink)

Memristor-based oscillators are of recent interest, and hence, in this paper, we introduce a new Wien bridge oscillator with a fractional-order memristor. The novelty of the proposed oscillator is the multistability feature and the wide range of fractional orders for which the system shows chaos. We have investigated the various dynamical properties of the proposed oscillator and have presented them in detail. The oscillator is then realized using off-the-shelf components, and the results are compared with that of the (...) numerical results. A combination synchronization scheme is proposed which uses more than one driver systems to synchronize with one response system. Indeed, we use two different techniques where the first one consists of splitting the transmitted signals into two parts where each part is loaded in different drive systems, while the second one consists of dividing time into different intervals and loading the signals in different drive systems. Such techniques improve the antiattack capability of the systems when used for secure communication. (shrink)

In the face of economic and political changes following the end of the Soviet Union, total fertility rates fell significantly across the post-Soviet world. In this study we examine the dramatic fertility transition in one community in which the total fertility rate fell from approximately five children per woman before 1993 to just over one child per woman a decade later. We apply hypotheses derived from evolutionary ecology and demography to the question of fertility transition in the post-Soviet period, focusing (...) on an indigenous community (Ust’-Avam) in the Taimyr Region, northern Russia. We employ a mixed parametric accelerated failure-time model that allows comparison of age at first birth, interbirth interval, and reproductive postponement or cessation prior to and following 1993. We find that short-term reproductive delay alone does not explain the dramatic drop in fertility in Ust’-Avam. Age at first birth remains constant. Interbirth intervals increase moderately. The estimated fraction of women who have ceased or indefinitely postponed reproducing doubles (for parities 2 through 4) or triples (for nulliparous women). We caution against assuming that environmental harshness necessarily leads to earlier and more rapid reproduction. An evolutionary theory of fertility responses to acute environmental shocks remains relatively undeveloped. In such contexts it is possible that selection favors a conservative reproductive strategy while more information is learned about the new environment. When investigating fertility responses to environmental stressors we suggest researchers examine postponement and stopping behavior in addition to changes in age at first birth and interbirth interval. (shrink)

ABSTRACTFractions are defined by numerical relationships, and comparing two fractions’ magnitudes requires within-fraction and/or between-fraction relational comparisons. To better understand how individuals spontaneously reason about fractions, we collected eye-tracking data while they performed a fraction comparison task with conditions that promoted or obstructed different types of comparisons. We found evidence for both componential and holistic processing in this mixed-pairs task, consistent with the hybrid theory of fraction representation. Additionally, making within-fraction eye movements on trials that promoted a between-fraction comparison strategy (...) was associated with slower responses. Finally, participants who performed better on a non-numerical test of reasoning took longer to respond to the most difficult fraction trials, which suggests that those who had greater facility with non-numerical reasoning attended more to numerical relationships. These findings extend pri... (shrink)

Is Rabinowitz seriously suggesting that his “rules” of reading are equally applicable to the analysis of British and American forms of popular writing and their readerships between 1920 and the 1960s? Is he seriously suggesting that Gone with the Wind, for example, would be “read” in the same way and for the same meanings in the southern states, the northern states, in Yorkshire and London? In this particular case the issue of cultural reproduction is also crucial—the complex relations between the (...) book and film “texts” and readerships for both. Is the book now read “through” the film and the mythos of Hollywood? Can the novel’s “history” of the Civil War and the period of Reconstruction be seen in relation to experience of the Depression on the one hand and to dominant historical discourses of the period privileged within American educational institutions on the other?2Or, if we take a British example like A. J. Cronin, whose work was regarded as both “serious” and “popular” in the late 1930s, what happens to Rabinowitz’s distinction? Clearly, Cronin’s fiction is not “acceptable” in the literary canon but his example illustrates the weakness of any critical analysis of the popular rooted in “literary” assumptions. Very important questions are raised by the commercial success of The Citadel, not among “the people” in any generalized sense but among specific constituencies of professional, middle-class readerships in both New Deal American and in Britain during a period of history remarkable for the regrouping of the forces of social-democratic consensus politics—an alliance between “sympathetic” fractions of the professional middle class and “the people” which culminated eventually in the postwar Labour party election victory. Thus readers are not only readers, and the processes of reading—especially perhaps of popular fiction—are not reducible to abstract rules which exclude all considerations of cultural=political institutions and discourses. 2. This example is partly indebted to discussion with Greg Gaut and Jane P. Tompkins during a University of Minnesota Conference, “On the Social Edge” . Derek Longhurst is principal lecturer and course leader in communication studies at Sunderland Polytechnic and general editor of the forthcoming series Culture and Popular Fiction. His publications include chapters in Re-Reading English and An Introduction to Contemporary Cultural Studies. He is currently working on a book about the political thriller. (shrink)

The umbrella-term ‘executive functions’ includes various domain-general, goal-directed cognitive abilities responsible for behavioral self-regulation. The influential unity and diversity model of EF posits the existence of three correlated yet separable executive domains: inhibition, shifting and updating. These domains may be influenced by factors such as socioeconomic status and culture, possibly due to the way EF tasks are devised and to biased choice of stimuli, focusing on first-world testees. Here, we propose a FREE test battery that includes two open-access tasks for (...) each of the three abovementioned executive domains to allow latent variables to be obtained. The tasks were selected from those that have been shown to be representative of each domain, that are not copyrighted and do not require special hardware/software to be administered. These tasks were adapted for use in populations with varying SES/schooling levels by simplifying tasks/instructions and using easily recognized stimuli such as pictures. Items are answered verbally and tasks are self-paced to minimize interference from individual differences in psychomotor and perceptual speed, to better isolate executive from other cognitive abilities. We tested these tasks on 146 early adolescents of both sexes and varying SES, because this is the age group in which the executive domains of interest become distinguishable and in order to confirm that SES effects were minimized. Performance was determined by Rate Correct Scores, which consider speed-accuracy trade-offs. Scores were sensitive to the expected improvement in performance with age and rarely/inconsistently affected by sex and SES, as expected, with no floor or ceiling effects, or skewed distribution, thus suggesting their adequacy for diverse populations in these respects. Using structural equation modeling, evidence based on internal structure was obtained by replicating the three correlated-factor solution proposed by the authors of the model. We conclude that the FREE test battery, which is open access and described in detail, holds promise as a tool for research that can be adapted for a wide range of populations, as well as altered and/or complemented in coming studies. (shrink)

i would like to begin by heaping some well-merited laud upon Robert Cummings Neville, henceforth to be referred to simply as Bob. His architectonics, in this book and almost all his others, are perhaps only rivaled by Kant and Whitehead, and the profundity of his thinking is only surpassed by the breadth of his learning. Specifically, I am convinced that his knowledge of non-Western thought is unsurpassed by his peers. I, however, will refer to but a fraction of what he (...) has to teach us about non-Western thought, as I must admit that this is generally above my pay grade.In a recent issue of American Journal of Theology & Philosophy, Bob has a small article... (shrink)

If fractional-reserve demand deposits are common, and illegitimate, an obvious flaw in the banking system is exposed. However, this article maintains that the only reason why demand deposits may be considered illegitimate is because of a way of defining them that renders them almost irrelevant. This article provides a response to Bagus et al., and identifies examples of how they misrepresent Evans. It also provides further considerations on the tradeoffs relating to the availability of a deposit; methodological subjectivism; (...) and the potential for hybrid contracts. Deposit and loan contracts may be hard to mix, but the actual results of doing so should not be ignored. (shrink)

We provide new evidence that the prosocial attitudes of local residents play a significant role in determining a firm’s corporate social responsibility engagement. We show that firms are more likely to engage in CSR initiatives when they are headquartered in areas with large senior citizen populations and where a large fraction of the population makes charitable donations. In contrast, we find that firms are less likely to engage in CSR initiatives when they are headquartered in areas with large religiously affiliated (...) groups. After establishing the local demographic roots of CSR demand, we then examine the relationship between the firm’s CSR activities and its market valuation. Our results suggest that CSR initiatives create value when they are properly aligned with local residents’ prosocial attitudes. Overall, our study stresses the role of local residents’ CSR preferences in mediating the relationship between CSR and market valuations. (shrink)

The rate‐limiting step in the uptake and metabolism of Dglucose by insulin target cells is thought to be glucose transport mediated by glucose transporters (primarily the GLUT4 isoform) localized to the plasma membrane. However, subcellular fractionation, photolabelling and immunocytochemical studies have shown that the pool of GLUT4 present in the plasma membrane is only one of many subcellular pools of this protein. GLUT4 has been found in occluded vesicles at the plasma membrane, clathrin‐coated pits and vesicles, early endosomes, and tubulo‐vesicular (...) structures; the latter are analogous to known specialized secretory compartments. Tracking the movement of GLUT4 through these compartments, and defining the mechanism and site of action of insulin in stimulating this subcellular trafficking, are major topics of current investigation. Recent evidence focuses attention on the exocytosis of GLUT4 as the major site of insulin action. Increased exocytosis may be due to decreased retention of glucose transporters in an intracellular pool, or possibly to increased assembly of a vesicle docking and fusion complex. Although details are unknown, the presence in GLUT4 vesicles of a synaptobrevin homologue leads us to propose that a process analogous to that occurring in synaptic vesicle trafficking is involved in the assembly of GLUT4 vesicles into a form suitable for fusion with the plasma membrane. Evidence that the pathways of signalling from the insulin receptor and of GLUT4 vesicle exocytosis may converge at the level of the key signalling enzyme, phosphatidylinositol 3‐kinase, is discussed. (shrink)

There is a growing appreciation of the extent of transcriptome variation across individual cells of the same cell type. While expression variation may be a byproduct of, for example, dynamic or homeostatic processes, here we consider whether single‐cell molecular variation per se might be crucial for population‐level function. Under this hypothesis, molecular variation indicates a diversity of hidden functional capacities within an ensemble of “identical” cells, and this functional diversity facilitates collective behavior that would be inaccessible to a homogenous population. (...) In reviewing this topic, we explore possible functions that might be carried by a heterogeneous ensemble of cells; however, this question has proven difficult to test, both because methods to manipulate molecular variation are limited and because it is complicated to define, and measure, population‐level function. We consider several possible methods to further pursue the hypothesis that “variation is function” through the use of comparative analysis and novel experimental techniques. (shrink)

The problem of moral luck is that a general fact about luck and an intuitive moral principle jointly imply the following skeptical conclusion: human beings are morally responsible for at most a tiny fraction of each action. This skeptical conclusion threatens to undermine the claim that human beings deserve their respective eternal reward and punishment. But even if this restriction on moral responsibility is compatible with the doctrine of the final judgment, the quality of one’s afterlife within heaven or hell (...) still appears to be lucky. Utilizing recent responses to the problem of moral luck, I explore several Molinist accounts of the final judgment that resolve both theological problems of moral luck. Some of these accounts entirely eliminate moral luck while others ensure that the moral luck involved in the judgment is overall good luck. (DOWNLOAD the published version at the external link below.). (shrink)

Background Various authorities recommend the participation of patients in promoting patient safety, but little is known about health care professionals' (HCPs') attitudes towards patients' involvement in safety-related behaviours. Objective To investigate how HCPs evaluate patients' behaviours and HCP responses to patient involvement in the behaviour, relative to different aspects of the patient, the involved HCP and the potential error. Design Cross-sectional fractional factorial survey with seven factors embedded in two error scenarios (missed hand hygiene, medication error). Each survey included (...) two randomized vignettes that described the potential error, a patient's reaction to that error and the HCP response to the patient. Setting Twelve hospitals in Switzerland. Participants A total of 1141 HCPs (response rate 45%). Measurements Approval of patients' behaviour, HCP response to the patient, anticipated effects on the patient–HCP relationship, HCPs' support for being asked the question, affective response to the vignettes. Outcomes were measured on 7-point scales. Results Approval of patients' safety-related interventions was generally high and largely affected by patients' behaviour and correct identification of error. Anticipated effects on the patient–HCP relationship were much less positive, little correlated with approval of patients' behaviour and were mainly determined by the HCP response to intervening patients. HCPs expressed more favourable attitudes towards patients intervening about a medication error than about hand sanitation. Conclusions This study provides the first insights into predictors of HCPs' attitudes towards patient engagement in safety. Future research is however required to assess the generalizability of the findings into practice before training can be designed to address critical issues. (shrink)

Nearly all fractions within the political, economic, and social spheres gave responses to the recent financial crisis. In broad terms, both left-leaning and right-leaning scholars and commentators presented their explanations for the crisis, with confident agendas defining ‘what is wrong’ and how to deal with it. However, as intellectual history shows us, most of those explanations were no less fascinating precisely because they shared more that they acknowledged. A major divide has been over the role of governments in coordinating markets, (...) or, in the case of Roberts’sThe Logic of Discipline, the role of markets in coordinating governments. In this essay, I offer an overview of Alasdair Roberts’s arguments inThe Logic of Discipline. Gradually, I extend the examined issues beyond the state-market dichotomy, arguing that only in understanding the interactive force of the two can a systemic analysis of capitalism hope to be plausible. (shrink)

One of the most influential recent developments in supposedly radical philosophy is ‘posthumanism’. This can be seen as the successor to ‘deconstructive postmodernism’. In each case, the claim of its proponents has been that cultures are oppressive by virtue of their elitism, and this elitism, fostered by the humanities, is being challenged. In each case, however, these philosophical ideas have served ruling elites by crippling opposition to their efforts to impose markets, concentrate wealth and power and treat everyone and everything (...) as mere instruments in a way that is not only undermining democracy and threatening economic, social and political stability through growing inequality, but is crippling efforts to deal with the global ecological crisis. Philosophers, Nietzsche claimed, are physicians of culture. Why should people claiming to be philosophers, or at least aligned with philosophers, subvert their own calling? In this paper I will suggest that with the expansion of education and the rise of neoliberalism, those involved in education and research, particularly in the humanities and social sciences, have been proletarianized, and most have accepted this proletarianization. They have been reduced to a fraction of the proletariat - wage-slaves without economic security and therefore dependent on the will of others on whom they are dependent. They are not ordinary wage-slaves, however, but wage-house-slaves, having salaries rather than wages. If, as Marx argued, social being determines consciousness, posthumanism can be understood as the expression of ressentiment of these house-slaves at their condition while simultaneously serving to affirm their superiority to field-slaves while serving their masters. Their work is supported because it provides ideological cover for their masters, the new transnational managerial class or corporatocracy as they expand their power through information technology, while absolving this corporatocracy from responsibility for the consequences of their growing power. In making this claim I will argue that the real target of deconstructionists and posthumanists, although this is now seldom appreciated, has been the humanism of the New Left, a revival of the Radical Enlightenment inspired by Renaissance civic humanism and the German Renaissance. (shrink)

Philosophy and its descendents in the behavioral sciences have traditionally divided incentives into those that are sought and those that are avoided. Positive incentives are held to be both attractive and memorable because of the direct effects of pleasure. Negative incentives are held to be unattractive but still memorable (the problem of pain) because they force unpleasant emotions on an individual by an unmotivated process, either a hardwired response (unconditioned response) or one substituted by association (conditioned response). (...) Negative incentives are divided into those that are always avoided and those that are avoided only by higher mental processes—archetypically the passions, which are also thought of as hardwired or conditioned. Newer dichotomies within the negative have been proposed, hinging on whether a negative incentive is nevertheless sought (“wanted but not liked”) or on an incentive's being negative only because it is confining (the product of “rule worship”). The newer dichotomies have lacked motivational explanations, and there is reason to question conditioning in the motivational mechanism for the older ones.

Both experimental findings and the examination of common experience indicate that even the most aversive experiences, such as pain and panic, do not prevail in reflex fashion, but because of an urge to attend to them. The well-established hyperbolic curve in which prospective rewards are discounted implies a mechanism for such an urge, as well as for the “lower” incentives in the other dichotomies. The properties of these lower incentives are predicted by particular durations of temporary preferences on a continuum that stretches from fractions of a second to years. (shrink)

This paper is an imitative response to Kathleen Stock’s book Material Girls, another faux chapter. This effort may be fractionally closer by some measures than my previous effort. I include an appendix with my own response to the essayist targeted: Alain Robbe-Grillet.

Perception of temporal patterns is fundamental to normal hearing, speech, motor control, and music. Certain types of pattern understanding are unique to humans, such as musical rhythm. Although human responses to musical rhythm are universal, there is much we do not understand about how rhythm is processed in the brain. Here, I consider findings from research into basic timing mechanisms and models through to the neuroscience of rhythm and meter. A network of neural areas, including motor regions, is regularly implicated (...) in basic timing as well as processing of musical rhythm. However, fractionating the specific roles of individual areas in this network has remained a challenge. Distinctions in activity patterns appear between "automatic" and "cognitively controlled" timing processes, but the perception of musical rhythm requires features of both automatic and controlled processes. In addition, many experimental manipulations rely on participants directing their attention toward or away from certain stimulus features, and measuring corresponding differences in neural activity. Many temporal features, however, are implicitly processed whether attended to or not, making it difficult to create controlled baseline conditions for experimental comparisons. The variety of stimuli, paradigms, and definitions can further complicate comparisons across domains or methodologies. Despite these challenges, the high level of interest and multitude of methodological approaches from different cognitive domains (including music, language, and motor learning) have yielded new insights and hold promise for future progress. (shrink)

This chapter examines the pioneering work of Gottfried Wilhelm Leibniz (1646-1716) on various number systems, in particular binary, which he independently invented in the mid-to-late 1670s, and hexadecimal, which he invented in 1679. The chapter begins with the oft-debated question of who may have influenced Leibniz’s invention of binary, though as none of the proposed candidates is plausible I suggest a different hypothesis, that Leibniz initially developed binary notation as a tool to assist his investigations in mathematical problems that were (...) exercising him at the time, namely those concerning the divisibility of composite numbers, primality, and perfect numbers. The chapter then explores Leibniz’s development of binary, his little-known work on binary fractions and expansions, his use of binary as a symbol for creation in his philosophical-theology, and his response to the suggestion that there was a correlation between binary numeration and the hexagrams of the ancient Chinese divinatory text, the Yijing. The chapter then focuses on Leibniz’s work on other number systems, in particular his invention and exploration of hexadecimal as well as his work on duodecimal. The chapter concludes by revealing a hitherto unknown practical application of binary that Leibniz devised in the last year of his life. (shrink)

What does it mean to devote yourself wholly to helping others? In Strangers Drowning, Larissa MacFarquhar seeks out people living lives of extreme ethical commitment and tells their deeply intimate stories; their stubborn integrity and their compromises; their bravery and their recklessness; their joys and defeats and wrenching dilemmas. A couple adopts two children in distress. But then they think: If they can change two lives, why not four? Or ten? They adopt twenty. But how do they weigh the needs (...) of unknown children in distress against the needs of the children they already have? Another couple founds a leprosy colony in the wilderness in India, living in huts with no walls, knowing that their two small children may contract leprosy or be eaten by panthers. The children survive. But what if they hadn't? How would their parents' risk have been judged? A woman believes that if she spends money on herself, rather than donate it to buy life-saving medicine, then she's responsible for the deaths that result. She lives on a fraction of her income, but wonders: when is compromise self-indulgence and when is it essential? We honor such generosity and high ideals; but when we call people do-gooders there is skepticism in it, even hostility. Why do moral people make us uneasy? Between her stories, MacFarquhar threads a lively history of the literature, philosophy, social science, and self-help that have contributed to a deep suspicion of do-gooders in Western culture. Through its sympathetic and beautifully vivid storytelling, Strangers Drowning confronts us with fundamental questions about what it means to be human. In a world of strangers drowning in need, how much should we help, and how much can we help? Is it right to care for strangers even at the expense of those we are closest to? Moving and provocative, Strangers Drowning challenges us to think about what we value most, and why. From the Hardcover edition. (shrink)

The scientific knowledge needed to engage with policy issues like climate change, vaccination, and stem cell research often conflicts with our intuitive theories of the world. How resilient are our intuitive theories in the face of contradictory scientific knowledge? Here, we present evidence that intuitive theories in 10 domains of knowledge—astronomy, evolution, fractions, genetics, germs, matter, mechanics, physiology, thermodynamics, and waves—persist more than four decades beyond the acquisition of a mutually exclusive scientific theory. Participants were asked to verify two types (...) of scientific statements as quickly as possible: those that are consistent with intuition and those that involve the same conceptual relations but are inconsistent with intuition. Older adults were as accurate as younger adults at verifying both types of statements, but the lag in response times between intuition-consistent and intuition-inconsistent statements was significantly larger for older adults than for younger adults. This lag persisted even among professional scientists. Overall, these results suggest that the scientific literacy needed to engage with topics of global importance may be constrained by patterns of reasoning that emerge in childhood but persist long thereafter. (shrink)

Abstract (for the combined three Parts) This paper presents the simplest known theory of processes involved in a person’s unconscious and conscious achievements such as intending, perceiving, reacting and thinking. The basic principle is that an individual has mental states which possess quantitative causal powers and are susceptible to influences from other mental states. Mental performance discriminates the present level of a situational feature from its level in an individually acquired, multiple featured norm (exemplar, template, standard). The effect on output (...) of a moderate disparity between input and norm is scaled in a universal unit of discrimination (Weber’s fraction), with the norm’s level being zero. When one process converts separate sources of input into an output, their discriminative distances from norm are summated. Distinct processes converging on an output combine their discriminations from norm orthogonally. An output may be influenced by the constructs of other outputs as well as by inputs. Descriptive performance is the influence of one category of input on a verbal output. Reasoning is minimally the effect of one verbal process on another. In deeper mental processing, the influence on a response comes from a response construct modulating a description: this process gives the meaning to an emotion or a motive. Descriptive modulation of stimulation corresponds to a bodily sensation or other conceptualized percept. When an output is explained solely by sources of input, that response to the stimulation may be mediated unconsciously. Development of a person within physical and communal environments embodies such mental causation within material causation and acculturates that mind to social causation. (shrink)

Automation can bring the risk of technological unemployment, as employees are replaced by machines that can carry out the same or similar work at a fraction of the cost. Some believe that the appropriate response is to tax automation. In this paper, I explore the justifiability of view, maintaining that we can embrace automation so long as we compensate those employees whose livelihoods are destroyed by this process by creating new opportunities for employment. My contribution in this paper is (...) important not only because I develop a theoretical framework that we can use to resolve this urgent policy dispute—a dispute that has been discussed extensively by labour economists, tax lawyers, and policymakers, but largely neglected by political philosophers—but also because my analysis sheds lights on a wider range of controversies relating to the moral and political importance of unemployment. (shrink)

David Liebesman argues that we never count by identity. He generalizes from an argument that we don't do so with sentences indicating fractions, or with measurement sentences on their supposed count readings. In response, I argue that measurement sentences aren't covered by the thesis that we count by identity, in part because they don't have count readings. Then I use the data to which Liebesman appeals, in his argument that we don't count by identity using measurement sentences, in order (...) to rebut his argument that we don't count by identity using sentences indicating fractions. (shrink)

Public funders of health research have been widely criticized on the grounds that their allocations of funding for disease-specific research do not reflect the relative burdens imposed by different diseases. For example, the US National Institutes of Health spends a much greater fraction of its budget on HIV/AIDS research and a much smaller fraction on migraine research than their relative contribution to the US burden of disease would suggest. Implicit in this criticism is a normative claim: Insofar as the scientific (...) opportunities are equal, each patient merits research into their condition proportional to the burden of disease for which that condition is responsible. This claim—the proportional view—is widely accepted but has never been fully specified or defended. In this paper, I explain what is required to specify the view, attempt to do so in the most charitable way, and then critically evaluate its normative underpinnings. I conclude that a severity-weighted proportional view is defensible. I close by drawing out five key lessons of my analysis for health research priority-setting. (shrink)

The RAD6 pathway of budding yeast, Saccharomyces cerevisiae, is responsible for a substantial fraction of this organism's resistance to DNA damage, and also for induced mutagenesis. The pathway appears to incorporate two different recovery processes, both regulated by RAD6. The error‐prone recovery prcess accounts for only a small amount of RAD6‐dependent resistance, but probably all induced mutagenesis. The underlying mechanism, for error‐prone recovery is very likely to be translesion synthesis. The error‐free recovery process accounts for most of RAD6‐dependent resistace, but (...) its mechanism is less clear; it may entail error‐free bypass by template switching and/or DNA gap filling by recombination. RAD6 regulates these activities by ubiquitinateins, and the roles they play in error‐free and error‐prone recovery, have not yet been established. (shrink)

The sudden growth and glorification of the penal state in the United States after the mid-1970s (and in Western Europe two decades later) is not a response to the evolution of crime, but a reaction to—and a diversion from—the social insecurity produced by the fragmentation of wage labor and the destabilization of ethnoracial hierarchies following the discarding of the Fordist-Keynesian compact. It partakes of a new government of poverty wedding restrictive “workfare” and expansive “prisonfare,” which ensnares the precarious fractions (...) of the postindustrial proletariat in a carceral-assistential net designed to steer them towards deregulated employment or to contain them in their dispossessed neighborhoods and in the booming prisons that have become their satellites. This policy of penalization of urban marginality guided by moral behaviorism partakes of a broader reengineering and remasculinizing of the state that has rendered obsolete the traditional scholarly and policy division between welfare and crime. It must be grasped, not under the narrow rubric of repression, but under the generative category of production, as it has spawned new state agencies, social types, knowledges and experts. It makes the study of incarceration an essential chapter in the sociology of the state and social stratification in the era of triumphant neoliberalism. (shrink)

The sudden growth and glorification of the penal state in the United States after the mid-1970s (and in Western Europe two decades later) is not a response to the evolution of crime, but a reaction to—and a diversion from—the social insecurity produced by the fragmentation of wage labor and the destabilization of ethnoracial hierarchies following the discarding of the Fordist-Keynesian compact. It partakes of a new government of poverty wedding restrictive “workfare” and expansive “prisonfare,” which ensnares the precarious fractions (...) of the postindustrial proletariat in a carceral-assistential net designed to steer them towards deregulated employment or to contain them in their dispossessed neighborhoods and in the booming prisons that have become their satellites. This policy of penalization of urban marginality guided by moral behaviorism partakes of a broader reengineering and remasculinizing of the state that has rendered obsolete the traditional scholarly and policy division between welfare and crime. It must be grasped, not under the narrow rubric of repression, but under the generative category of production, as it has spawned new state agencies, social types, knowledges and experts. It makes the study of incarceration an essential chapter in the sociology of the state and social stratification in the era of triumphant neoliberalism. (shrink)

People often struggle with Bayesian reasoning. However, research showed that people’s performance (and rationality) can be supported by the way of representing the statistical information. First, research showed that using natural frequencies instead of probabilities as format of statistical information increases people’s performance in Bayesian situations thoroughly. Second, research also yielded that people’s performance increases through using visualization. We build our paper on existing research in this field. The main aim is to analyse people’s strategies in Bayesian situations that are (...) still erroneous although statistical information is represented by natural frequencies and visualizations. In particular, we compare two pairs of visualization with similar numerical information (tree diagram vs. unit square and double-tree diagram vs. 2x2-table) concerning their impact on people’s erroneous strategies in Bayesian situations. For this aim, we conducted an experiment with 540 university students. The students were randomly assigned to four conditions that are defined by the four different visualizations of statistical information. The students were asked to indicate a fraction as response in four Bayesian situations. We documented the numerator and the denominator of the students’ responses representing a basic set and a subset in a Bayesian situation. Our results show that people’s erroneous strategies are highly dependent on the visualization. A central finding is that the visualization’s characteristic of making the nested-sets structure of a Bayesian situation transparent has a facilitating effect on people’s Bayesian reasoning. For example, compared to the unit square, a tree diagram does not explicitly visualize the set-subset relations that are relevant in a Bayesian situation. Accordingly, compared to a unit square, a tree diagram partly hinders people to find the correct denominator in a Bayesian situation, and, in particular, triggers to select a wrong numerator. By analyzing people’s erroneous strategies in Bayesian situations, we contribute to investigating approaches to facilitate Bayesian reasoning and to further develop the teaching of Bayesian reasoning. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Liberalism, Art, and FundingDale Francis MurrayLiberalism, Art, and FundingSince Ronald Dworkin published A Matter of Principle, a host of critics have attempted to systematically dismantle his arguments advocating state support for the arts that appear in a chapter entitled, "Can a Liberal State Support Art?"1 The combined critical force of Noël Carroll, Samuel Black, and most recently, Harry Brighouse, has dislodged the main supports of Dworkin's position on this (...) subject.2 However, while I am skeptical that the arguments of liberals who endorse state support for the arts can be fully resurrected, I reckon that a few remarks can be presented to try to deflect at least a fraction of the contentions cast on Dworkin's argument by the critics listed above. In order to refine our understanding of precisely why state support for cultural expression should or should not be permitted, it is imperative that some sort of response to the critics of state support for the arts is offered.In this essay, I focus primarily on Brighouse's objections that Dworkin's arguments supporting arts funding fail primarily because they are not sensitive enough to the ways in which such support violates two demands of justice in a liberal state — state neutrality and publicity. I examine these two objections since they seem to be the most interesting, compelling, and damaging to Dworkin's case if substantiated. If Brighouse is correct, these violations act as heavy bulwarks against state support for arts funding, especially since public distrust of the state's intent (and the state's perceived advocacy of notions of the good with which the public disagrees) is high. I will employ Brighouse's neutrality of intent constraint, because it best represents the alleged specific violations of state neutrality that may undermine Dworkin's case. Additionally, neutrality of intent is the most plausible form of neutrality for advocates of public arts funding to build a case for in the space of a short essay.I also wish to make a distinction, which for the most part, is ignored by Dworkin's critics — that there is a degree to which moral value and aesthetic value are different and that this effects a possible alternative reading of the term "ways of life" as most liberals understand it. As a final note of preface, I will assume that the background conditions of income and wealth are just.3 This proviso will become important when we examine the role of the market in funding arts projects in lieu of the government. Now let us reiterate the two requirements of any just liberal state that are at issue when considering the legitimacy of state support for the arts. [End Page 116]Brighouse sets the pair of constraints on any just liberal state (neutrality and publicity) as the centerpieces of his essay. Neutrality of intent, that he appeals to more specifically, can be understood to mean, as Brighouse himself explains, "[T]hat while it is unobjectionable that state actions will have differential effects on conceptions of the good, the government should not intend to favor some conceptions over others" (NPS, 38, emphasis mine). The publicity constraint can be characterized by saying that in any just, liberal regime, justice must not only be done, but it must also be seen as being done. While this serves as the motto of the publicity constraint, it is significant to acknowledge that it stipulates that the real reasons for governmental action must be comprehensible to, and available for inspection by, reasonable citizens. In addition, it must be readily apparent to citizens that the demands of justice are being met. I will return to this constraint on the state later in this essay.Neutrality is of chief interest, since recent liberal political philosophers have emphasized the primacy of the right over the good (RLD, 245). Presumably, individuals, via their rational autonomy, shall define the good for themselves beyond the dictates of government. Our morality is our own personal affair, just so long as we remain within the confines of the harm principle and do not violate the equal liberty of others.On the surface, it is not apparent that state funding for the... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Liberalism, Art, and FundingDale Francis MurrayLiberalism, Art, and FundingSince Ronald Dworkin published A Matter of Principle, a host of critics have attempted to systematically dismantle his arguments advocating state support for the arts that appear in a chapter entitled, "Can a Liberal State Support Art?"1 The combined critical force of Noël Carroll, Samuel Black, and most recently, Harry Brighouse, has dislodged the main supports of Dworkin's position on this (...) subject.2 However, while I am skeptical that the arguments of liberals who endorse state support for the arts can be fully resurrected, I reckon that a few remarks can be presented to try to deflect at least a fraction of the contentions cast on Dworkin's argument by the critics listed above. In order to refine our understanding of precisely why state support for cultural expression should or should not be permitted, it is imperative that some sort of response to the critics of state support for the arts is offered.In this essay, I focus primarily on Brighouse's objections that Dworkin's arguments supporting arts funding fail primarily because they are not sensitive enough to the ways in which such support violates two demands of justice in a liberal state — state neutrality and publicity. I examine these two objections since they seem to be the most interesting, compelling, and damaging to Dworkin's case if substantiated. If Brighouse is correct, these violations act as heavy bulwarks against state support for arts funding, especially since public distrust of the state's intent (and the state's perceived advocacy of notions of the good with which the public disagrees) is high. I will employ Brighouse's neutrality of intent constraint, because it best represents the alleged specific violations of state neutrality that may undermine Dworkin's case. Additionally, neutrality of intent is the most plausible form of neutrality for advocates of public arts funding to build a case for in the space of a short essay.I also wish to make a distinction, which for the most part, is ignored by Dworkin's critics — that there is a degree to which moral value and aesthetic value are different and that this effects a possible alternative reading of the term "ways of life" as most liberals understand it. As a final note of preface, I will assume that the background conditions of income and wealth are just.3 This proviso will become important when we examine the role of the market in funding arts projects in lieu of the government. Now let us reiterate the two requirements of any just liberal state that are at issue when considering the legitimacy of state support for the arts. [End Page 116]Brighouse sets the pair of constraints on any just liberal state (neutrality and publicity) as the centerpieces of his essay. Neutrality of intent, that he appeals to more specifically, can be understood to mean, as Brighouse himself explains, "[T]hat while it is unobjectionable that state actions will have differential effects on conceptions of the good, the government should not intend to favor some conceptions over others" (NPS, 38, emphasis mine). The publicity constraint can be characterized by saying that in any just, liberal regime, justice must not only be done, but it must also be seen as being done. While this serves as the motto of the publicity constraint, it is significant to acknowledge that it stipulates that the real reasons for governmental action must be comprehensible to, and available for inspection by, reasonable citizens. In addition, it must be readily apparent to citizens that the demands of justice are being met. I will return to this constraint on the state later in this essay.Neutrality is of chief interest, since recent liberal political philosophers have emphasized the primacy of the right over the good (RLD, 245). Presumably, individuals, via their rational autonomy, shall define the good for themselves beyond the dictates of government. Our morality is our own personal affair, just so long as we remain within the confines of the harm principle and do not violate the equal liberty of others.On the surface, it is not apparent that state funding for the... (shrink)

Public funders of health research have been widely criticized on the grounds that their allocations of funding for disease-specific research do not reflect the relative burdens imposed by different diseases. For example, the US National Institutes of Health spends a much greater fraction of its budget on HIV/aids research and a much smaller fraction on migraine research than their relative contribution to the US burden of disease would suggest. Implicit in this criticism is a normative claim: Insofar as the scientific (...) opportunities are equal, each patient merits research into their condition proportional to the burden of disease for which that condition is responsible. This claim—the proportional view—is widely accepted but has never been fully specified or defended. In this paper, I explain what is required to specify the view, attempt to do so in the most charitable way, and then critically evaluate its normative underpinnings. I conclude that a severity-weighted proportional view is defensible. I close by drawing out five key lessons of my analysis for health research priority-setting. (shrink)

In this paper we extend an argument originally developed in Hülsmann to analyze changes to the structure of production that occur when the demand for money changes. In particular, we show that Hülsmann’s argument, which contrasted such changes under commodity and fiat systems, applies as well to the case of 100% reserve systems contrasted with fractional reserve free banking systems . Specifically, we argue that under a 100% reserve system, the structure of production will change in response to (...) a change in demand for money, and that it will not under FR/FB. In fact, such changes are beneficial. Since one of the central arguments in defense of FR/FB is precisely the fact that it avoids such changes to the structure of production , we conclude that this argument amounts to comparing different mechanisms for attaining different equilibrium states, and hence is invalid as a defense of that mechanism as such. (shrink)

Background: Pain has been associated with structural changes of the brain. However, evidence regarding white matter changes in response to acute pain protocols is still scarce. In the present study, we assess the existence of differences in brain white matter related to pain intensity reported by patients undergoing surgical removal of a mandibular impacted third molar using diffusion tensor imaging analysis.Methods: 30 participants reported their subjective pain using a visual analog scale at three postsurgical stages: under anesthesia, in pain, (...) and after the administration of an analgesic. The diffusion data were acquired prior to surgery.Results: DTI analysis yielded significant positive associations of fractional anisotropy in white matter areas related to pain processing with the differences in pain between the three postsurgery stages. Extent and location of these associations depended on the magnitude of the subjective pain differences. Tractography analysis indicated that some pain–tract associations are significant only when pain stage is involved in the contrast, while others are only when anesthesia is involved in the contrast.Conclusions: The association of white matter fractional anisotropy and connectivity, measured before the pain stages, with subjective pain depends on the magnitude of the differences in pain scores. (shrink)

Online educational technologies offer opportunities for providing individualized feedback and detailed profiles of students' skills. Yet many technologies for mathematics education assess students based only on the correctness of either their final answers or responses to individual steps. In contrast, examining the choices students make for how to solve the equation and the ways in which they might answer incorrectly offers the opportunity to obtain a more nuanced perspective of their algebra skills. To automatically make sense of step‐by‐step solutions, we (...) propose a Bayesian inverse planning model for equation solving that computes an assessment of a learner's skills based on her pattern of errors in individual steps and her choices about what sequence of problem‐solving steps to take. Bayesian inverse planning builds on existing machine learning tools to create a generative model relating (mis)‐understandings to equation solving choices. Two behavioral experiments demonstrate that the model can interpret people's equation solving and that its assessments are consistent with those of experienced teachers. A third experiment uses this model to tailor guidance for learners based on individual differences in misunderstandings, closing the loop between assessing understanding, and using that assessment within an educational technology. Finally, because the bottleneck in applying inverse planning to a new domain is in creating the model of possible student misunderstandings, we show how to combine inverse planning with an existing production rule model to make inferences about student misunderstandings of fraction arithmetic. (shrink)

The COVID-19 pandemic has brought to light significant failures and fragilities in our food, health, and market systems. Concomitantly, it has emphasized the urgent need for a critical re-evaluation of many of the policies and practices that have created the conditions in which viral pathogens can spread. However, there are many factors that are complicating this process; among others, the uncertain, rapidly evolving, and often poorly reported science surrounding the virus’ origins has contributed to a politically charged and often rancorous (...) public debate, which is concerning insofar as the proliferation of divisive discourse may hinder efforts to address complex and collective concerns in a mutually cooperative manner. In developing ethical and effective responses to the disproportionate risks associated with certain food production and consumption practices, we argue that the focus should be on mitigating such risks wherever they arise, instead of seeking to ascribe blame to specific countries or cultures. To this end, this article is an effort to inject some nuance into contemporary conversations about COVID-19 and its broader implications, particularly when it comes to trade in wildlife, public health, and food systems reform. If COVID-19 is to represent a turning point towards building a more equitable, sustainable, and resilient world for both humans and nonhuman animals alike, the kind of fractioning that is currently being exacerbated by the use of loaded terms such as “wet market” must be eschewed in favour of a greater recognition of our fundamental interconnectedness. (shrink)

In this article we debate how the meanings of gesture language eroticize bodies in two online artistic references: the amateur videos of people masturbating themselves from the website “Beautiful Agony” ( www.beautifulagony.com ), which show faces only; and the “My Luxuria” series, by the artist Alex Kliszynski ( www.ask-art.net ), where in the pictures, models who are naked and in erotic positions have their bodies replaced by bodies which resemble a “Barbie” doll. Once we are facing the images of fractioned (...) bodies we may ask to what extent the meaning forged in the erotic experience finds in the gesture something that widens the possibilities of signification of these images. We believe that the observer sees these images through the lenses of the experience which is responsible for signifying the erotic in his/her ordinary life. Language – verbal or non-verbal – causes the incarnation of the meaning into the experience. Its expressive nature gives shape to ways of “being in the world” and perceiving it. (shrink)

Before going further, it will be helpful to consider briefly the notion that novelty per se is a fundamental human need. Experiments with human beings, as well as with animals, indicate that the maintenance of normal, successful behavior depends upon an adequate level of incoming stimulation—or, as some have put it, of novelty.2 But lumping all novelty together is misleading. At least three kinds of novelty need to be distinguished. Some novel patterns arise out of, or represent, changes in the (...) fundamental rules governing the organization of musical processes and structures. By significantly weakening our comprehension of the musical relationships presented—undermining not only our understanding of what is past but our ability to envisage what is to come—such systemic change seriously threatens our sense of psychic security and competent control. Far from being welcome, the insecurity and uncertainty thus engendered is at least as antipathetic, disturbing, and unpleasant as stimulus privation. Novel patterns may also result from the invention of a new strategy that accords with prevalent stylistic rules. Though they may initially seem to threaten existing competencies, the function and significance of novel strategies within the larger set of stylistic constraints can usually be grasped without too much delay or difficulty. For a while the tensions produced by strategic innovation may seem disturbing. But in the end, when our grasp of the principles ordering events is confirmed and our sense of competency is reestablished and control is reinforced, tension is resolved into an elation that is both stimulating and enjoyable. Most novel patterns—original themes, rhythms, harmonic progressions, and so forth—involve the innovative instantiation or realization of an existing strategy or schema .3 Novelties of this kind not only enhance our sense of control—a feeling that we know how things really “work”—but provide both the pleasure of recognition and the joy of skillfully exercising some competency. We enjoy novelty—the stimulation of surprise, the tension of uncertainty—as long as it can be accommodated within a known and understandable set of constraints. When the rules governing the game are abrogated or in doubt—when comprehension and control are threatened—the result is usually anger, anguish, and desperation.These responses to novelty are consequences of fundamental and poignant verities of the human condition: the centrality of choice in human behavior. Because only a minute fraction of human behavior seems to be genetically specified, choice is inescapable.While in lower organisms, behavior is strictly determined by the genetic program, in complex metazoa the genetic program becomes less constraining, more “open” as Ernst Mayr puts it, in the sense that it does not lay down behavioral instructions in great detail but rather permits some choice and allows for a certain freedom of response. Instead of imposing rigid prescriptions, it provides the organism with potentialities and capacities. This openness of the genetic program increases with evolution and culminates in mankind.4The price of freedom is the imperative of choice. Human beings must choose were to sow and when to reap, when to work and where to live, when to play and what to build. Intelligent, successful choices are possible only if alternative courses of action can be imagined and their consequences envisaged with reasonable accuracy. 2. For further discussion, see my Music, the Arts, and Ideas , p. 50.3. Rules are transpersonal but intracultural constraints—for instance, the pitch/time entities established in some style, as well as grammatical and syntactic regularities. Strategies are general means for actualizing some of the possibilities that are potential in the rules of the style. The rules of a style are relatively few, while the number of possible strategies may, depending upon the nature of the rules, be very large indeed. The ways of instantiating a particular strategy are, if not infinite, at least beyond reckoning.4. François Jacob, The Possible and the Actual , p. 61. See also Stephen Jay Gould, Ever Since Darwin , p. 257. (shrink)

Reproduction places severe demands on the energy metabolism in human females. When physical work entails higher energy expenditure, not enough energy will be left for the support of the reproductive processes and temporal suppression of the reproductive function is expected. While energy needed for reproduction may be obtained by increases in energy intake, utilization of fat reserves, or reallocation of energy from basal metabolism, several environmental or physiological constraints render such solutions unlikely. For human ancestors increases in energy intake were (...) limited by availability of food, by labor of food preparation and by metabolic ceilings to energy assimilation. Energy stored as fat may support only a fraction of the requirements for reproduction (especially lactation). Effects of intense physical activity on basal metabolism may also interfere with fat accumulation during pregnancy. Finally, the female physiology may experience demands on increasing the basal metabolism as a consequence of physical activity and, at the same time, on decreasing the basal metabolism, when energy to support the ongoing pregnancy or lactation is inadequate. The resulting metabolic dilemmas could constitute a plausible cause for the occurrence of reproductive suppression in response to physical activity. It is, therefore, likely that allocating enough energy to the reproductive processes during periods when energy expenditure rises may be difficult due to physiological and bioenergetic constraints. Females attempting pregnancy in such conditions may compromise their lifetime reproductive output. A reproductive suppression occurring in low energy availability situations may thus represent an adaptive rather then a pathological response. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Alzheimer's Disease, Mild Cognitive Impairment, and the Biology of Intrinsic AgingThomas B. L. Kirkwood (bio)Keywordsaging, Alzheimer’s disease, genetic mutation, mild cognitive impairment, telomereThe article by Gaines and Whitehouse (2006) raises key questions about the uncertain relationship between (i) the intrinsic, "normal" aging process, and (ii) the clinicopathologic states represented by the labels of Alzheimer's disease (AD) and mild cognitive impairment (MCI). This short commentary offers a perspective on this (...) debate that is drawn from a consideration of underlying biological mechanisms.Because age is unquestionably the greatest single risk factor associated with AD and MCI, I begin by asking what we know about the intrinsic processes of aging. The central feature of current understanding of intrinsic aging is that it consists of the gradual, lifelong accumulation of a wide variety of molecular and cellular faults that begins very early in life and eventually leads to overt functional impairments resulting in age-related frailty, disability, and disease (Kirkwood 2005). This is an essentially bottom-up process. A strong consensus has emerged in recent years that there is no active program for aging and that there are no genetic factors that have evolved specifically to cause aging or age-related diseases. Unquestionably, there are genes that influence susceptibility to disease and even length of life, but these genes are genes for maintenance and repair functions, not for aging. It is the limitation in the past evolutionary pressure to invest in greater longevity than was required, within an environment where life was usually truncated by hazards such as starvation, injury, or infection, that means that our maintenance systems—good as they are—are insufficient to keep us going indefinitely. Added to this is the idea that there are probably also genes that program processes that are good for the young organism, but which may in later life have harmful effects. Processes like inflammation and apoptosis, which are seen to occur extensively in aged tissues, including brain, surely evolved to help cope with infection and cellular damage arising earlier in life. That they are called into play in aged tissues is a direct, but secondary, consequence of accumulated damage.With this general framework to understand the intrinsic biology of aging, let us now ask what we might expect a priori for the aging of an organ such [End Page 79] as the brain. Although we cannot pretend complete ignorance of how the brain actually does age, our enquiry can be based entirely on data from other organ systems, so we can develop our predictions about brain aging without prejudice.Aging begins very early during human development, faults accumulating from the first stages of embryonic development. Each time a cell divides, each of the daughter cells is likely to acquire a few new mutations. We know this from the estimates for the error rate in DNA replication and the size of the human genome. It is confirmed by direct evidence that at individual gene loci where mutations have been measured, mutation frequency increases with age (Morley 1998; Vijg 2000). In addition to replication errors, DNA is damaged on a daily basis to a very considerable degree by agents such as reactive oxygen species (free radicals), which are formed as byproducts of normal cellular metabolism. Although most of this damage is corrected by repair, the repair mechanisms themselves are not error free and additional mutations accumulate through this route. If a mutation is lethal to the cell, the cell dies and thus the mutation is eliminated. However, the majority of mutations are nonlethal, either because the mutation is recessive and the cell carries an intact gene copy on the other chromosome, because the gene is not currently required, or because the mutation produces only a delayed deleterious effect. Examples of genes that produce delayed deleterious effects include the genes responsible for familial AD. It is interesting to reflect that on statistical grounds alone, it is almost certain that each of us carries a randomly determined fraction of cells in our brains that bear amyloid precursor protein or presenilin mutations associated with AD. We also carry a heterogeneous array of random mutations that compromise essential cell maintenance functions. How many such... (shrink)

Sensory processing dysfunction is characterized by a behaviorally observed difference in the response to sensory information from the environment. While the cerebellum is involved in normal sensory processing, it has not yet been examined in SPD. Diffusion tensor imaging scans of children with SPD and typically developing controls were compared for fractional anisotropy, mean diffusivity, radial diffusivity, and axial diffusivity across the following cerebellar tracts: the middle cerebellar peduncles, superior cerebellar peduncles, and cerebral peduncles. Compared to TDC, children (...) with SPD show reduced microstructural integrity of the SCP and MCP, characterized by reduced FA and increased MD and RD, which correlates with abnormal auditory behavior, multisensory integration, and attention, but not tactile behavior or direct measures of auditory discrimination. In contradistinction, decreased CP microstructural integrity in SPD correlates with abnormal tactile and auditory behavior and direct measures of auditory discrimination, but not multisensory integration or attention. Hence, altered cerebellar white matter organization is associated with complex sensory behavior and attention in SPD, which prompts further consideration of diagnostic measures and treatments to better serve affected individuals. (shrink)

The urban poise is dependent on a particular notion of urban planning: a myriad of actions that can adjust civic life in many places to provoke it towards greater self-esteem. Urban planning is not consecrated by a drawing in the shape of a plan alone, but it must respect the elevation of the stance of an urban spectacle as seen from the sidewalk. The coercion of civic indicators is reappraised by delighting in the figurative stance of the informant city. Small (...) things are done in the city within its existing urban structure so that an edge is applied to what already exists. City blocks might be fractionally altered, holes in the skyline reamed out smooth, and points located strategically so that they can carry their attendant responsibilities. The method is marginally parasitic, for it exists by requiring something else to exist that it cannot readily harbor.Ten points and places of vulnerability have been chosen in the city that poke at its underbelly. Whilst the poises are given names and specific sites, their viability could be felt equally in a different city using changed names. The Appliance House franchises its intention to various matters of civic consequence, ranging from the weather to shopping to the monumental respect for the dead. Each poise is considered integrally related to the wholeness of the city. If any of the Poises becomes disassociated from the city or from other Poises, the prime tenet of urban existence will have been ignored: the over-exertion of one component of urban life will take place at the expense of somebody else. Ben Nicholson is studio professor of architecture at the Illinois Institute of Technology. His Appliance House will be published later this year. (shrink)

Effective altruism is the project of using resources like time and money to help others as much as possible. Those who engage in this project—effective altruists—tend to focus on three ways of helping.First, effective altruists focus on helping people living in extreme poverty and typically support interventions that prevent diseases such as malaria, trachoma, and schistosomiasis. These interventions have been shown to be highly cost-effective. For example, it costs on average about $4,500 to prevent someone from dying of malaria.Second, effective (...) altruists focus on reducing animal suffering. For example, tens of billions of animals are raised each year on factory farms. The conditions on these farms are so poor that the animals’ lives are probably not worth living. A host of charities aim to improve conditions on these farms or reduce the number of animals raised on them.Finally, effective altruists focus on improving the long-term future. This often takes the form of safeguarding the very existence of humanity's future by reducing risks of existential catastrophe posed by threats like nuclear weapons, pandemics, and artificial intelligence. It is frequently argued that, since there is vast value in avoiding such catastrophes, reducing the risk of any of them even fractionally has relatively high expected value.Each of these three ways of helping has been argued to be the most cost-effective way to help, that is, what makes the biggest positive difference, per dollar donated (or hour of time volunteered). There is disagreement among effective altruists over which of these areas, if any, should be the top priority.The effective altruism social movement has been around since about 2011 and now has thousands of supporters and is backed by billions of dollars in donations. At the same time, the project, underlying philosophy, and social movement of effective altruism have attracted substantial criticism, voiced in very visible venues. The present special issue of PAQ deals with a range of philosophical issues at the heart of this ongoing public debate. Below is a very brief overview of the articles in this issue.In “Why Not Effective Altruism?” Richard Yetter Chappell takes a careful look at criticisms that have been offered against effective altruism. He focuses on four ideas associated with effective altruism that have received particular attention, including moral prioritization, earning to give, billionaire philanthropy, and longtermism. Chappell argues that, in each case, the core moral claims of effective altruism cannot reasonably be rejected.In “Effective Altruists Need Not Be Pronatalist Longtermists,” Tina Rulli offers a sustained rebuttal to the argument for longtermism presented by William MacAskill in his recent book What We Owe the Future. In particular, she objects to pronatalist longtermism, which favors extensively populating the future, provided the future will be on balance good. Rulli argues that taking account of moral considerations most would recognize shows this position to be implausible. Her view is nonetheless compatible with versions of longtermism that focus on preventing harms to future people.In “How (Not) to Fear Death,” Susanne Burri provides a fresh perspective on the ancient question of whether we should fear death. She argues that, on a wide range of theories of well-being, it can be fitting to fear death. Burri argues that having a proper philosophical understanding of our reasons to fear death is in fact essential to reducing our death-related fears. This, she argues, provides an example of philosophical therapy, a neglected type of intervention effective altruists should consider. Given that the dissemination of valuable philosophical insight is so cheap, and could significantly benefit so many, it can and should be pursued alongside more resource-intensive interventions such as distributing malaria nets or reducing existential risks.In “Effective Altruism and Requiring Reasons to Help Others,” Thomas Sinclair provides a response to one of the main claims of my recent (2023) book The Rules of Rescue. I claim that each of us has a requiring reason (or pro tanto duty) to prevent harm to others, whenever we have the opportunity to do so. I argue that since these opportunities are ubiquitous, so, too, are requiring reasons. In response, Sinclair argues that we have requiring reasons to help others only when we engage with the plights of these others in a certain way. That engagement is not ubiquitous; it is present in cases of nearby emergency rescues, but it is not present simply whenever we can donate to effective charities.Philosophical debates surrounding effective altruism have developed rapidly over the past decade or so. As the articles in this special issue suggest, there is still much to be explored. (shrink)

Environmentalists who seek to protect wild nature, biodiversity and so on for its own sake manifest a disposition to value the interesting at least on par with the useful. This disposition toward the interesting, which provides the affective and cognitive context for the discovery of intrinsic values in nature and the elaboration of ecocentric ethics, does not arise simply from learning about nature but is part of a more general socially inculcated cultural system. Nature connoisseurship exhibits formal parallels with art (...) connoisseurship. The abstraction-oriented cultural system which prizes 'disinterested interest' is characteristic of culturally rich fractions (or subdivisions) of the middle class in modern Western societies. Valuing nature for its own sake (like valuing, for its own sake, the domination of nature) is not a 'natural' response to nature but a disciplined cultural accomplishment. (shrink)

In this paper, we empirically explore some manifestations of norms for the conduct of science. We focus on scientific research ethics and report survey results from 606 scientists who received funding in 1993 and 1994 from the Division of Molecular and Cellular Biology of the Biology Directorate of the National Science Foundation. We also report results for 91 administrators charged with overseeing research integrity at the scientists’ research institutions. Both groups of respondents were presented with a set of scenarios, designed (...) by fractional factorial methods, describing different kinds of scientific conduct that in the eyes of some would likely be unethical. Respondents then were asked to evaluate each of these scenarios for how unethical the behavior might be and what kinds of sanctions might be appropriate. We use the responses to consider the nature of consensus around norms related to the practice of science and in particular, similarities and differences between scientists and science administrators. Implications for policy are also discussed. (shrink)

During the last few months, several pioneer genome‐wide transcriptomic, proteomic and metabolomic studies have revolutionised the understanding of bacterial biological processes, leading to a picture that resembles eukaryotic complexity. Technological advances such as next‐generation high‐throughput sequencing and high‐density oligonucleotide microarrays have allowed the determination, in several bacteria, of the entire boundaries of all expressed transcripts. Consequently, novel RNA‐mediated regulatory mechanisms have been discovered including multifunctional RNAs. Moreover, resolution of bacterial proteome organisation (interactome) and global protein localisation (localizome) have unveiled an (...) unanticipated complexity that highlights the significance of protein multifunctionality and localisation in the cell. Also, analysis of a complete bacterial metabolic network has again revealed a high fraction of multifunctional enzymes and an unexpectedly high level of metabolic responses and adaptation. Altogether, these novel approaches have permitted the deciphering of the entire physiological landscape of one of the smallest bacteria, Mycoplasma pneumoniae. Here, we summarise and discuss recent findings aimed at defining the blueprint of any prokaryote. (shrink)