We argue against some of Reichenbach's claims about causal forks are incorrect. We do not see why the Second Law of Thermodynamics rules out the existence of conjunctive forks open to the past. In addition, we argue that a common effect rarely forms a conjunctive fork with its joint causes, but it sometimes does. Nevertheless, we think there is something to be said for Reichenbach's idea that forks of various kinds are relevant to explaining why we know more about the (...) past than about the future. And entropy turns out to play a role in the explanation, though not the determining role that Reichenbach envisions. (shrink)

Is the mechanism behind presupposition projection and filtering fundamentally asymmetric or symmetric? This is a foundational question for the theory of presupposition which has been at the centre of attention in recent literature. It also bears on broader issues concerning the source of asymmetries observed in natural language: are these simply rooted in superficial asymmetries of language use ; or are they, at least in part, directly encoded in linguistic knowledge and representations? In this paper we aim to make (...) progress on these questions by exploring presupposition projection across conjunction, which has traditionally been taken as a central piece of evidence that presupposition filtering is asymmetric in general. As a number of authors have recently pointed out, however, the evidence which has typically been used to support this conclusion is muddied by independent issues concerning redundancy; additional concerns have to do with the possibility of local accommodation. We report on a series of experiments, building on previous work by Chemla and Schlenker :177–226, 2012 and Schwarz 2015), using inference and acceptability tasks, which aim to control for both of these potential confounds. In our results, we find strong evidence for left-to-right filtering across conjunctions, but no evidence for right-to-left filtering—even when right-to-left filtering would, if available, rescue an otherwise unacceptable sentence. These results suggest that presupposition filtering across conjunction is asymmetric, contra suggestions in the recent literature :157–212, 2008a.), and pave the way for the investigation of further questions about the nature of this asymmetry and presupposition projection more generally. Our results also have broader implications for the study of presupposition: we find important differences in the verdicts of acceptability versus inference tasks in testing for projected content, which has both methodological ramifications for the question of how to distinguish presupposed content, and theoretical repercussions for understanding the nature of projection and presuppositions more generally. (shrink)

Is the mechanism behind presupposition projection and filtering fundamentally asymmetric or symmetric? This is a foundational question for the theory of presupposition which has been at the centre of attention in recent literature :287–316, 2008b. https://doi.org/10.1515/THLI.2008.021, Semant Pragmat 2:1–78, 2009. https://doi.org/10.3765/sp.2.3; Rothschild in Semant Pragmat 4:1–43, 2011/2015. https://doi.org/10.3765/sp.4.3 a.o.). It also bears on broader issues concerning the source of asymmetries observed in natural language: are these simply rooted in superficial asymmetries of language use ; or are they, at least (...) in part, directly encoded in linguistic knowledge and representations? In this paper we aim to make progress on these questions by exploring presupposition projection across conjunction, which has traditionally been taken as a central piece of evidence that presupposition filtering is asymmetric in general. As a number of authors have recently pointed out, however, the evidence which has typically been used to support this conclusion is muddied by independent issues concerning redundancy; additional concerns have to do with the possibility of local accommodation. We report on a series of experiments, building on previous work by Chemla and Schlenker :177–226, 2012. https://doi.org/10.1007/s11050-012-9080-7) and Schwarz Experimental perspectives on presuppositions, Springer, Cham, 2015), using inference and acceptability tasks, which aim to control for both of these potential confounds. In our results, we find strong evidence for left-to-right filtering across conjunctions, but no evidence for right-to-left filtering—even when right-to-left filtering would, if available, rescue an otherwise unacceptable sentence. These results suggest that presupposition filtering across conjunction is asymmetric, contra suggestions in the recent literature :157–212, 2008a. https://doi.org/10.1515/THLI.2008.013, 2009 a.o.), and pave the way for the investigation of further questions about the nature of this asymmetry and presupposition projection more generally. Our results also have broader implications for the study of presupposition: we find important differences in the verdicts of acceptability versus inference tasks in testing for projected content, which has both methodological ramifications for the question of how to distinguish presupposed content, and theoretical repercussions for understanding the nature of projection and presuppositions more generally. (shrink)

When people combine concepts these are often characterised as “hybrid”, “impossible”, or “humorous”. However, when simply considering them in terms of extensional logic, the novel concepts understood as a conjunctive concept will often lack meaning having an empty extension (consider “a tooth that is a chair”, “a pet flower”, etc.). Still, people use different strategies to produce new non-empty concepts: additive or integrative combination of features, alignment of features, instantiation, etc. All these strategies involve the ability to deal with conflicting (...) attributes and the creation of new (combinations of) properties. We here consider in particular the case where a Head concept has superior ‘asymmetric’ control over steering the resulting concept combination (or hybridisation) with a Modifier concept. Specifically, we propose a dialogical approach to concept combination and discuss an implementation based on axiom weakening, which models the cognitive and logical mechanics of this asymmetric form of hybridisation. (shrink)

Is the basic mechanism behind presupposition projection fundamentally asymmetric or symmetric? This is a basic question for the theory of presupposition, which also bears on broader issues concerning the source of asymmetries observed in natural language: are these simply rooted in superficial asymmetries of language use— language use unfolds in time, which we experience as fundamentally asymmetric— or can they be, at least in part, directly referenced in linguistic knowledge and representations? In this paper we aim to make (...) progress on these questions by exploring presupposition projection across conjunction, which has typically been taken as a central piece of evidence that presupposition projection is asymmetric. As a number of authors have recently pointed out, however, whether or not this conclusion is warranted is not clear once we take into account independent issues of redundancy. Building on previous work by Chemla & Schlenker (2012) and Schwarz (2015), we approach this question experimentally by using an inference task which controls for redundancy and presupposition suspension. We find strong evidence for left-to-right filtering across conjunctions, but no evidence for right-to-left filtering, suggesting that, at least as a default, presupposition projection across conjunction is indeed asymmetric. (shrink)

Lepore and Stone seek to replace the rationality-based Gricean picture of coordination between speaker and hearer with one leaning more strongly on the roles of convention and speaker knowledge while doing away with conversational implicature. Focusing on the phenomena of indirect speech acts, asymmetric conjunction, and scalar inferencing, I argue that the case for abandoning implicature as an analytical tool is not ultimately compelling. I seek further to demonstrate the utility of the classical Gricean distinction between what is said (...) and what is implicated in the construction of an intuitively appealing approach to the perennial question of how to distinguish lying from misleading inside and outside the legal domain. (shrink)

One of the outstanding achievements of recent cosmology has been to offer some prospect of a unified explanation of temporal asymmetry. The explanation is in two main parts, and runs something like this. First, the various asymmetries we observe are all thermodynamic in origin – all products of the fact that we live in an epoch in which the universe is far from thermodynamic equilibrium. Second, this thermodynamic disequilibrium is associated with the condition of the universe very soon after the (...) Big Bang – the essential point being that in the rapidly expanding universe of the time, gravity is able to create organisation much faster than other processes can destroy it. The stars, galaxies and other forms of organisation we find in the present universe are all products of this early period. Such concentrated energy sources themselves make possible the kinds of asymmetric phenomena with which we are most familiar, such as life itself. If this explanation proves to be right it will surely rank as one of the most impressive achievements in the whole of natural philosophy. Where else do we find this breathtaking scale, this extraordinary conjunction of fundamental physics, the first moments of Creation, the possibility of life and the basic character of human experience? And it is very much a contemporary achievement: even if its roots go back on one side to the investigation of time asymmetry in nineteenth century statistical mechanics, and on the other to Hubble's discovery in the 1920's of the expansion of the universe, the body of the picture has only begun to be filled in in the last twenty or thirty years. This fascinating story has recently been given some well-deserved publicity in Stephen Hawking's bestseller, A Brief History of Time – well-deserved, not least, because Hawking himself is responsible for a considerable part of the story as it presently stands. (shrink)

In this paper, I present a case study on a recent attempt at implementing what I refer to as the “Pro-lifer’s Asymmetrical Punishment View” (PAPV), the view that people should be legally punished for performing abortions whereas women should not be so punished for procuring abortions. While doing so, I argue that the endeavor, which took place in the state of Alabama, is incoherent relative to the conjunction of its purported underlying moral rationale and the Alabama criminal code. I then (...) present what I take to be possible explanations for, practical implications of, and solutions to the attempt and its incoherence. Given that other endeavors to implement PAPV are currently in the works and are so with similar underlying moral rationales and within similar criminal codes, what I present and argue here is not limited to Alabama’s attempt at doing so. (shrink)

This paper is a response to Enguehard (Natural Language Semantics 29(4):527–578, 2021 ), who observes that presuppositions project in the same way from coordinations of declaratives and coordinations of polar questions, but existing mechanisms of projection from declaratives (e.g. Schlenker in Theoretical Linguistics 34(3):157–212, 2008, Semantics and Pragmatics 2:1–78, 2009 ) fail to scale to questions. His solution involves specifying a trivalent inquisitive semantics for (coordinations of) questions that bakes the various asymmetries of presupposition projection into the lexical entry of (...) conjunction/disjunction. However, we argue that such a move faces both theoretical and empirical issues. Instead, we show that the data can be handled without moving to such an asymmetric inquisitive denotation, by adapting the novel pragmatic theory of _Limited Symmetry_ (Kalomoiros in Proceedings of the 52nd annual meeting of the North East linguistic society, GLSA, Amherst, 2022 ) to an inquisitive framework in a way that leaves the underlying semantics for conjunction symmetric and bivalent, while deriving the projection data. (shrink)

Tissues are shaped and patterned by mechanical and chemical processes. A key mechanical process is the positioning of the mitotic spindle, which determines the size and location of the daughter cells within the tissue. Recent force and position-fluctuation measurements indicate that pushing forces, mediated by the polymerization of astral microtubules against­ the cell cortex, maintain the mitotic spindle at the cell center in Caenorhabditis elegans embryos. The magnitude of the centering forces suggests that the physical limit on the accuracy and (...) precision of this centering mechanism is determined by the number of pushing microtubules rather than by thermally driven fluctuations. In cells that divide asymmetrically, anti-centering, pulling forces generated by cortically located dyneins, in conjunction with microtubule depolymerization, oppose the pushing forces to drive spindle displacements away from the center. Thus, a balance of centering pushing forces and anti-centering pulling forces localize the mitotic spindles within dividing C. elegans cells. We discuss microtubule-based mechanisms of the mitotic spindle positioning, a key mechanical process that shapes and patterns tissues. The magnitude of the centering forces indicates that the physical limit on the accuracy and precision of centering is set by the number of contributing microtubules rather than by thermally driven fluctuations. (shrink)

Tissues are shaped and patterned by mechanical and chemical processes. A key mechanical process is the positioning of the mitotic spindle, which determines the size and location of the daughter cells within the tissue. Recent force and position-fluctuation measurements indicate that pushing forces, mediated by the polymerization of astral microtubules against­ the cell cortex, maintain the mitotic spindle at the cell center in Caenorhabditis elegans embryos. The magnitude of the centering forces suggests that the physical limit on the accuracy and (...) precision of this centering mechanism is determined by the number of pushing microtubules rather than by thermally driven fluctuations. In cells that divide asymmetrically, anti-centering, pulling forces generated by cortically located dyneins, in conjunction with microtubule depolymerization, oppose the pushing forces to drive spindle displacements away from the center. Thus, a balance of centering pushing forces and anti-centering pulling forces localize the mitotic spindles within dividing C. elegans cells. We discuss microtubule-based mechanisms of the mitotic spindle positioning, a key mechanical process that shapes and patterns tissues. The magnitude of the centering forces indicates that the physical limit on the accuracy and precision of centering is set by the number of contributing microtubules rather than by thermally driven fluctuations. (shrink)

It has long been believed across languages that the Agent‐First strategy, a comprehension heuristic that maps the first noun onto the agent role, is a general cognitive bias which applies automatically and faithfully to children's comprehension. The present study asks how this strategy interplays with such grammatical cues as the number of overt arguments and the presence of case‐marking in Korean, an SOV language with case‐marking by dedicated markers. To investigate whether and how these cues affect the operation of this (...) strategy, we measure children's comprehension of a transitive construction (with scrambling and omission of sentential components) in a novel experimental setting where arguments and case markers were obscured to varying degrees through acoustic masking. We find that children do not demonstrate the agent‐first interpretation strongly in the noun–verb pattern without case‐marking, showing their uncertainty about the thematic role of the nominal when it is both the only argument in the sentence and lacks case‐marking. They perform significantly better in the patterns with additional cues, the impact of which is asymmetric by age and by the nature of alignment between cues from word order and case‐marking. These findings suggest that, for Korean‐speaking children's comprehension of a transitive construction, the Agent‐First strategy is activated properly only in conjunction with other types of interpretive cues. (shrink)

This article is a preliminary presentation of conjunctive paraconsistency, the claim that there might be non-explosive true contradictions, but contradictory propositions cannot be considered separately true. In case of true ‘p and not p’, the conjuncts must be held untrue, Simplification fails. The conjunctive approach is dual to non-adjunctive conceptions of inconsistency, informed by the idea that there might be cases in which a proposition is true and its negation is true too, but the conjunction is untrue, Adjunction fails. While (...) non-adjunctivism is a well-known option, the other view is not so much studied nowadays, but it was not unknown in the tradition, and there are some positive suggestions, in recent literature, that the position is plausible and deserves to be developed. The article compares conjunctivism, non-adjunctivism and dialetheism, then focuses on some possible justifications, costs and benefits of the conjunctive view. (shrink)

Two enzymes involved in the synthesis of pyrimidine and purine nucleotides, CTP synthase (CTPS) and IMP dehydrogenase (IMPDH), can assemble into a single or very few large filaments called rods and rings (RR) or cytoophidia. Most recently, asymmetric cytoplasmic distribution of organelles during cell division has been described as a decisive event in hematopoietic stem cell fate. We propose that cytoophidia, which could be considered as membrane‐less organelles, may also be distributed asymmetrically during mammalian cell division as previously described (...) for Schizosaccharomyces pombe. Furthermore, because each type of nucleotide intervenes in distinct processes (e.g., membrane synthesis, glycosylation, and G protein‐signaling), alterations in the rate of synthesis of specific nucleotide types could influence cell differentiation in multiple ways. Therefore, we hypothesize that whether a daughter cell inherits or not CTPS or IMPDH filaments determines its fate and that this asymmetric inheritance, together with the dynamic nature of these structures enables plasticity in a cell population. (shrink)

The conjunction fallacy is the well-documented empirical finding that subjects sometimes rate a conjunction A&B as more probable than one of its conjuncts, A. Most explanations appeal in some way to the fact that B has a high probability. But Tentori et al. (2013) have recently challenged such approaches, reporting experiments which find that (1) when B is confirmed by relevant evidence despite having low probability, the fallacy is common, and (2) when B has a high probability but has not (...) been confirmed by relevant evidence, the fallacy is less common. They conclude that degree of confirmation, rather than probability, is the central determinant of the conjunction fallacy. In this paper, we address a confound in these experiments: Tentori et al. (2013) failed to control for the fact that their (1)-situations make B conversationally relevant, while their (2)-situations do not. Hence their results are consistent with the hypothesis that con- versationally relevant high probability is an important driver of the conjunction fallacy. Inspired by recent theoretical work that appeals to conversational relevance to explain the conjunction fallacy, we report on two experiments that control for this issue by making B relevant without changing its degree of probability or confirmation. We find that doing so increases the rate of the fallacy in (2)-situations, and leads to comparable fallacy-rates as (1)-situations. This suggests that (non-probabilistic) conversational relevance indeed plays a role in the conjunction fallacy, and paves the way toward further work on the interplay between relevance and confirmation. (shrink)

Desire-satisfaction theories of welfare must answer the timing question: when do you benefit from the satisfaction of one of your desires? There are three existing views about this: the Time of Desire view, on which you benefit at just those times when you have the desire; the Time of Object view, on which you benefit just when the object of your desire obtains; and Concurrentism, on which you benefit just when you have the desire and its object obtains. This paper (...) introduces a new view, Asymmetrism, on which you sometimes benefit at the time of desire and sometimes benefit at the time of object. On this view, if the time at which you have a desire is later than the time at which its object obtains, then you benefit at the time of the desire. On the other hand, if the time of object is later than the time of desire, then you benefit at the time of object. Three arguments are given for the conclusion that Asymmetrism is superior to the Time of Desire and Time of Object views. It is argued that Asymmetrism and Concurrentism are the most credible answers to the timing question. (shrink)

In this paper, I argue on empirical grounds that (VL-initial) Asymmetric Coordination in German cannot be reduced to a syntactic structure of the form [if S1, then S2], but rather needs to be analyzed as some kind of adjunction to the if-clause, i.e., along the lines of [[if S1] and S2]. This conclusion gives rise to an apparent mismatch between syntactic structure (narrow scope of if) and semantic interpretation (wide scope of if). To resolve this paradoxical situation, I propose (...) a compositional semantics for conditionals that is based on the idea that (indexed) if is to be construed as some kind of anaphor (variable) that ranges over objects of type modal base picking up a modal background in the actual context. Even though this analysis assigns a non-vacuous semantics to the complementizer if, it is still compatible with the syntax of Asymmetric Coordination in German, and, in contrast to alternative accounts, avoids the generation of non-existent distributive readings. (shrink)

In this paper we discuss the extent to which conjunction and disjunction can be rightfully regarded as such, in the context of infectious logics. Infectious logics are peculiar many-valued logics whose underlying algebra has an absorbing or infectious element, which is assigned to a compound formula whenever it is assigned to one of its components. To discuss these matters, we review the philosophical motivations for infectious logics due to Bochvar, Halldén, Fitting, Ferguson and Beall, noticing that none of them discusses (...) our main question. This is why we finally turn to the analysis of the truth-conditions for conjunction and disjunction in infectious logics, employing the framework of plurivalent logics, as discussed by Priest. In doing so, we arrive at the interesting conclusion that —in the context of infectious logics— conjunction is conjunction, whereas disjunction is not disjunction. (shrink)

1. In both Benedetto Croce's and Hegel's own terminology, dialectics can be understood as dottrina degli opposti (the doctrine of the opposites – Lehre der Gegensätze).1 In the dialectical process,...

I argue that it is rational for a person to believe the conjunction of her beliefs. This involves responding to the Lottery and Preface Paradoxes. In addition, I suggest that in normal circumstances, what it is to believe a conjunction just is to believe its conjuncts.

Personal identity is not always symmetric: even if I will not be a later person, the later person may have been me. What makes this possible is that the relations that are criterial of personal identity---such as memory and anticipation---are asymmetric and "count in favor of personal identity from one side only". Asymmetric personal identity can be accommodated by temporal counterpart theory but not by Lewisian overlapping aggregates of person stages. The question of uncertainty in cases of personal (...) fission (and in Everettian quantum mechanics) is also discussed. (shrink)

Three‐ to 4‐month‐old infants show asymmetric exclusivity in the acquisition of cat and dog perceptual categories. The cat perceptual category excludes dog exemplars, but the dog perceptual category does not exclude cat exemplars. We describe a connectionist autoencoder model of perceptual categorization that shows the same asymmetries as infants. The model predicts the presence of asymmetric retroactive interference when infants acquire cat and dog categories sequentially. A subsequent experiment conducted with 3‐ to 4‐month‐olds verifies the predicted pattern of (...) looking time behaviors. We argue that bottom‐up, associative learning systems with distributed representations are appropriate for modeling the operation of short‐term visual memory in early perceptual category learning. (shrink)

Our target article modeled conflict within and between groups as an asymmetric game of strategy and developed a framework to explain the evolved neurobiological, psychological, and sociocultural mechanisms underlying attack and defense. Twenty-seven commentaries add insights from diverse disciplines, such as animal biology, evolutionary game theory, human neuroscience, psychology, anthropology, and political science, that collectively extend and supplement this model in three ways. Here we draw attention to the superordinate structure of attack and defense, and its subordinate means to (...) meet the end of status quo maintenance versus change, and we discuss how variations in conflict structure and power disparities between antagonists can impact strategy selection and behavior during attack and defense; how the positions of attack and defense emerge endogenously and are subject to rhetoric and propaganda; and how psychological and economic interventions can transform attacker-defender conflicts into coordination games that allow mutual gains and dispute resolution. (shrink)

Plurality, Conjunction and Events presents a novel theory of plural and conjoined phrases, in an event-based semantic framework. It begins by reviewing options for treating the alternation between `collective' and `distributive' readings of sentences containing plural or conjoined noun phrases, including analyses from both the modern and the premodern literature. It is argued that plural and conjoined noun phrases are unambiguously group-denoting, and that the collective/distributive distinction therefore must be located in the predicates with which these noun phrases combine. More (...) specifically, predicates must have a hidden argument place for events; the collective/distributive distinction may then be represented in the part/whole structure of these events. This allows a natural treatment of `collectivizing' adverbial expressions, and of `pluractional' affixes; it also allows a unified semantics for conjunction, in which conjoined sentences and predicates denote groups of events, much like conjoined noun phrases denote groups of individuals. (shrink)

Three major ways in which temporal asymmetries enter into scientific induction are discussed as follows: 1. An account is given of the physical basis for the temporal asymmetry of recordability, which obtains in the following sense: except for humanly recorded predictions and one other class of advance indicators to be discussed, interacting systems can contain reliable indicators of only their past and not of their future interactions. To deal with the exceptional cases of non-spontaneous "pre-records," a clarification is offered of (...) the essential differences in the conditions requisite to the production of an indicator having retrodictive significance ("post-record"), on the one hand, and of one having predictive significance ("prerecord" or recorded prediction), on the other. Purported counter-examples to the asymmetry of spontaneous recordability are refuted. 2. It is shown how in cases of asymmetric recordability, the associated retrodiction-prediction asymmetry makes for an asymmetry of assertibility as between an explanandum (or an explanans) referring to a future event and one referring to a past one. But it is argued that this epistemological asymmetry in the assertibility per se must be clearly distinguished from a logical asymmetry between the past and the future in regard to the inferability (deductive or inductive) of the explanandum from the explanans. And it is then contended that the failure to distinguish between an epistemological and a logical asymmetry vitiates the critiques that recent writers have offered of the Popper-Hempel thesis, which affirms symmetry of inferability as between predictive and post-explanatory arguments. In reply to Scriven, it is maintained that predictions based on mere indicators (rather than causes) do not establish an asymmetry in scientific understanding as between predictive arguments and post-explanatory ones. 3. As a further philosophical ramification of the retrodiction-prediction asymmetry, a set of sufficient conditions are stated for the correctness of philosophical mechanism as opposed to teleology. (shrink)

I put in question in this article the existence of conjunctive properties. In the second section, after having provided a characterization of conjunctive properties, I develop an argument based on the principle of ontological parsimony: if we accept that there are conjunctive properties in the universe then, ceteris paribus, our ontology turns out to be less ontologically parsimonious than if we reject them. Afterwards, in the third section, I distinguish between maximalist and non-maximalist and reductionist and non-reductionist theories of conjunctive (...) properties., as well as between reductionist and non-reductionist theories that reject conjunctive properties. Such distinctions help to clarify the options at hand when accepting or rejecting conjunctive properties. In light of these distinctions, I then tackle two objections against the argument from ontological parsimony. Finally, in the remaining sections, I deal with two arguments defended by D. M. Armstrong for the existence of conjunctive properties: the argument from infinite complexity and the argument from causal powers. I show that there are several ways to resist these arguments and their conclusion. (shrink)

Gonzalo Rodriguez-Pereyra (2006) argues against attempts to preserve the entailment principle (or a restriction of it) while avoiding the explosion of truthmakers for necessities and truthmaker triviality. In doing so, he both defends the disjunction thesis--if something makes true a disjunctive truth, then it makes true one of its disjuncts--, and rejects the conjunction thesis--if something makes tue a conjunctive truth, then it makes true each of its conjuncts. In my discussion, I provide plausible counterexamples to the disjunction thesis, and (...) contend that Rodriguez-Pereyra's general defence of it fails. Then I defend the conjunction thesis from Rodriguez-Pereyra's case against it. (shrink)

According to Mitchell Green, speech act theory traditionally idealizes away from crucial aspects of conversational contexts, including those in which the speaker’s social position affects the possibility of her performing certain speech acts. In recent times, asymmetries in communicative situations have become a lively object of study for linguists, philosophers of language and moral philosophers: several scholars view hate speech itself in terms of speech acts, namely acts of subordination. The aim of this paper is to address one of the (...) main objections to accounts of hate speech in terms of illocutionary speech acts, that is the Authority Problem. While the social role of the speaker is the focus of several approaches, the social role of the audience has too often been neglected. The author will show that not only must the speaker have a certain kind of standing or social position in order to perform speech acts of subordination, but also the audience must typically have a certain kind of standing or social position in order to either license or object to the speaker’s authority, and her acts of subordination. (shrink)

One persistent puzzle in the life sciences is the asymmetric lipid composition of the cellular plasma membrane: while the exoplasmic leaflet is enriched in lipids carrying predominantly saturated fatty acids, the cytoplasmic leaflet hosts preferentially lipids with (poly‐)unsaturated fatty acids. Given the high energy requirements necessary for cells to maintain this asymmetry, the question naturally arises regarding its inherent benefits. In this paper, we propose asymmetry to represent a potential solution for harmonizing two conflicting requirements for the plasma membrane: (...) first, the need to build a barrier for the uncontrolled influx or efflux of substances; and second, the need to form a fluid and dynamic two‐dimensional substrate for signaling processes. We hence view here the plasma membrane as a composite material, where the exoplasmic leaflet is mainly responsible for the functional integrity of the barrier and the cytoplasmic leaflet for fluidity. We reinforce the validity of the proposed mechanism by presenting quantitative data from the literature, along with multiple examples that bolster our model. (shrink)

A conjunction of two hypotheses may provide a better explanation than either one of them individually, even if each already provides a good explanation on its own. An appropriate measure of explanatory power should reflect this, but none of the measures discussed in the literature do so because they only consider how much an explanatory hypothesis reduces our surprise at the evidence – which is problematic. This chapter introduces and defends a class of coherentist measures of explanatory power, and shows (...) that one particular such measure that combines different intuitions underlying the epistemological notion of coherence overcomes the aforementioned problems of surprise reduction measures. (shrink)

The segregation of damaged components at cell division determines the survival and aging of cells. In cells that divide asymmetrically, such as Saccharomyces cerevisiae, aggregated proteins are retained by the mother cell. Yet, where and how aggregation occurs is not known. Recent work by Zhou and collaborators shows that the birth of protein aggregates, under specific stress conditions, requires active translation, and occurs mainly at the endoplasmic reticulum. Later, aggregates move to the mitochondrial surface through fis1‐dependent association. During replicative aging, (...) aggregate association with the mother‐cell mitochondria contributes to the asymmetric segregation of aggregates, because mitochondria in the daughter cell do not carry aggregates. With increasing age of mother cells, aggregates lose their connection to the mitochondria, and segregation is less asymmetric. Relating these findings to other mechanisms of aggregate segregation in different organisms, we postulate that fusion between aggregates and their tethering to organelles such as the vacuole, nucleus, ER, or mitochondria are common principles that establish asymmetric segregation during stress resistance and aging. (shrink)

Frequently, historical comparisons are asymmetrical in the sense that they investigate one case carefully while limiting themselves to a mere sketch of the other case which serve as comparative reference point. The debate on the German Sonderweg and the rich historical literature originating from this debate can serve as examples. This article reconstructs the pros and cons within this controversial debate, reports its results and puts it into a broader historical context. It analyzes the comparative logic implied by the Sonderweg (...) thesis and argues that the interpretation of modern German history in the sense of a Sonderweg can only be maintained if related to the question why Germany turned fascist and totalitarian in the interwar period while other societies did not, and if Western countries are selected as units of comparison. The choice of comparative reference points turns out to be decisive and partly dependent on normative priorities and conventions. The article points to dangers and opportunities inherent in asymmetrical comparison. (shrink)

We apply the method of asymmetric interpretation to the basic fragment of bounded arithmetic, endowed with a weak collection schema, and to a system of “feasible analysis”, introduced by Ferreira and based on weak König's lemma, recursive comprehension and NP-notation induction. As a byproduct, we obtain two conservation results.

The so‐called problem of irrelevant conjunction has been seen as a serious challenge for theories of confirmation. It involves the consequences of conjoining irrelevant statements to a hypothesis that is confirmed by some piece of evidence. Following Hawthorne and Fitelson, we reconstruct the problem with reference to Bayesian confirmation theory. Then we extend it to the case of conjoining irrelevant statements to a hypothesis that is dis confirmed by some piece of evidence. As a consequence, we obtain and formally present (...) a novel and more troublesome problem of irrelevant conjunction. We conclude by indicating a possible solution based on a measure‐sensitive approach and by critically discussing a major alternative way to address the problem. *Received December 2008; revised August 2009. †To contact the authors, please write to: Department of Philosophy, University of Turin, via Sant'Ottavio 20, 10124 Turin, Italy; e‐mail: [email protected] ; [email protected] or [email protected]. (shrink)

In this essay, I defend an account of right action that I shall call “asymmetrical virtue particularism.” An action, on this account, is right just insofar as it is overall virtuous. But the virtuousness of an action in any particular respect, X, is deontically variant; it can fail to be right-making, either because it is deontically irrelevant or because it is wrong-making. Finally, the account is asymmetrical insofar as the viciousness of actions is not deontically variant; if any action is (...) vicious in some respect Y, then Y is always a wrong-making feature of any action whatever that has Y. (shrink)

Asymmetric Choquet random walks are defined, in the form of dynamically consistent random walks allowing for asymmetric conditional capacities. By revisiting Kast and Lapied and Kast et al. we show that some findings regarding the effects of ambiguity aversion are preserved in the more general framework, which is of interest in several applications to policy making, risk management, corporate decisions, real option valuation of investment/ disinvestment projects, etc. The effect of ambiguity on the higher moments is investigated, as (...) well, as they have an interpretation in terms of the psychological attitude of a decision-maker towards ambiguity. Finally, some financial applications are provided as an illustration. (shrink)

The latest catchphrase to enter the English language as a result of military conflict is the term 'asymmetrical warfare'. At its broadest, asymmetrical warfare is simply any conflict in which there is a significant qualitative 1 mismatch between opponents in any or all of the following: manpower, firepower, technology and tactics. While the phrase is new, the concept is not. Asymmetrical warfare has been going on for about as long as humans have fought each other in organized ways. In the (...) South African context, for example, one need only think of the devastating attacks by King Shaka's highly-organized regiments (equipped as they were with revolutionary weaponry like the short stabbing spear or assegai), against the various tribes and groups that got in the way of Shaka's expansionist goals. Asymmetry was also an essential component in the successes of the rifle, canon and Gatling-gun equipped colonial armies who subdued the tribesmen of Africa and elsewhere. In the more recent past the ANC's low-tech guerrilla campaign against the conventional might of the apartheid regime is yet another example. There are, of course, complexities here, and asymmetries are not all of the same ilk, nor do they remain fixed, and certainly it is sometimes difficult to tell whether a conflict can properly be defined as asymmetrical. Nonetheless the general concept is easily recognizable. (shrink)

Starting from a recent paper by S. Kaufmann, we introduce a notion of conjunction of two conditional events and then we analyze it in the setting of coherence. We give a representation of the conjoined conditional and we show that this new object is a conditional random quantity, whose set of possible values normally contains the probabilities assessed for the two conditional events. We examine some cases of logical dependencies, where the conjunction is a conditional event; moreover, we give the (...) lower and upper bounds on the conjunction. We also examine an apparent paradox concerning stochastic independence which can actually be explained in terms of uncorrelation. We briefly introduce the notions of disjunction and iterated conditioning and we show that the usual probabilistic properties still hold. (shrink)

This article addresses the question whether companies benefit from their commitment to corporate social responsibility. The authors argue that firms which score high on CSR activities build investor confidence and find evidence that they benefit from lower information asymmetry. The authors measure information asymmetry by insider trading, which is defined as the trading of a company’s shares by corporate insiders who have an information advantage with the aim to reap gains or avoid losses. Using a sample of U.S. firms listed (...) in the MSCI World Index during the period 2004 to 2013 and the firm- and industry-level CSR rating from Global Engagement Service, the authors show that insider transactions in firms with a high score on CSR activities lead to lower abnormal returns. This investigation extends current literature on the business case for CSR by explaining the influence of CSR activities on asymmetric information. (shrink)

Analogies must be symmetric. If a is like b, then b is like a. So if a has property R, and if R is within the scope of the analogy, then b (probably) has R. However, analogical arguments generally single out, or depend upon, only one of a or b to serve as the basis for the inference. In this respect, analogical arguments are directed by an asymmetry. I defend the importance of this neglected – even when explicitly mentioned – (...) feature in understanding analogical arguments. (shrink)

Asymmetric cell division generates cell diversity and contributes to cellular aging and rejuvenation. Here, we review the molecular mechanisms enabling budding yeast to recognize spindle pole bodies (SPB, centrosome equivalent) based on their age, and guide their non‐random mitotic segregation: SPB inheritance requires the distinction of old from new SPBs and is regulated by the SPB‐inheritance network (SPIN) and the mitotic exit network (MEN). The SPIN marks the pre‐existing SPB as old and the MEN recognizes these marks translating them (...) into spindle orientation. We next revisit other molecules and structures that partition depending on their age rather than their abundance at mitosis as, for example, DNA, centrosomes, mitochondria, and histones in yeast and other systems. The recurrence of this differential behavior suggests a functional significance for numerous cell types, which we then discuss. We conclude that non‐random segregation may facilitate asymmetric cell fate determination and thereby indirectly aging and rejuvenation. (shrink)

One vexing question for Desire Satisfactionism is this: At what time do you benefit from a satisfied desire? Recently Eden Lin has proposed an intriguing answer. On this proposal – Asymmetrism – when past-directed desires are satisfied, the time interval during which you benefit is the time of the desire; and, when future-directed desires are satisfied, the time interval during which you benefit is the time of the object. In this essay, I argue that Asymmetrism forces us to give implausible (...) answers to a different question: To what extent does a given satisfied desire benefit you? (shrink)

This paper theoretically and experimentally investigates the behavior of asymmetric players in guessing games. The asymmetry is created by introducing r>1\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$r>1$$\end{document} replicas of one of the players. Two-player and restricted N-player cases are examined in detail. Based on the model parameters, the equilibrium is either unique in which all players choose zero or mixed in which the weak player (r=1\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$r=1$$\end{document}) imitates the (...) strong player (r>1\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$r>1$$\end{document}). A series of experiments involving two and three-player repeated guessing games with unique equilibrium is conducted. We find that equilibrium behavior is observed less frequently and overall choices are farther from the equilibrium in two-player asymmetric games in contrast to symmetric games, but this is not the case in three-player games. Convergence towards equilibrium exists in all cases but asymmetry slows down the speed of convergence to the equilibrium in two, but not in three-player games. Furthermore, the strong players have a slight earning advantage over the weak players, and asymmetry increases the discrepancy in choices (defined as the squared distance of choices from the winning number) in both games. (shrink)