This article proposes that the propagation of vibrations could serve as a better model for understanding the transmission of affect than the flow, circulation or movement of bodies by which it is most often theorized. The vibrations (or idiomatically ‘vibes’) among the sound system audience (or ‘crowd’) on a night out on the dancehall scene in Kingston, Jamaica, provide an example. Counting the repeating frequencies of these vibrations in a methodology inspired by Lefebvre’s rhythmanalysis results in a Frequency Spectrogram. (...) This ranges from the sociocultural frequencies of nightly, weekly and seasonal cycles and circulations of musical style and fashion, to the material frequencies of the amplitudes and timbres of sound itself, with reggae’s signature low-pitched bass-line, to the corporeal frequencies of the flesh and blood of the dancehall ‘crowd’, pulsating with heartbeats and kinetic dance rhythms. The vibration model then addresses the intensities of affect in terms of auditory amplitudes, as with sonic dominance; feelings as frequencies; and the distinctive meaning of affect as timbre. This aims to encourage the radical impulse of the idea of affect to abandon the traditional envelope of the autonomous, self-consistent, rational individual. The meaning of affect is thus located in the ratio, proportions and patterning of vibrations, that is, outside the discourse of emotions or representation of feelings. (shrink)

A quantum measurement-like event can produce any of a number of macroscopically distinct results, with corresponding macroscopically distinct gravitational fields, from the same initial state. Hence the probabilistically evolving large-scale structure of space-time is not precisely or even always approximately described by the deterministic Einstein equations.Since the standard treatment of gravitational wave propagation assumes the validity of the Einstein equations, it is questionable whether we should expect all its predictions to be empirically verified. In particular, one might expect the (...) stochasticity of amplified quantum indeterminacy to cause coherent gravitational wave signals to decay faster than standard predictions suggest. This need not imply that the radiated energy flux from gravitational wave sources differs from standard theoretical predictions. An underappreciated bonus of gravitational wave astronomy is that either detecting or failing to detect predicted gravitational wave signals would constrain the form of the semi-classical theory of gravity that we presently lack. (shrink)

As companies increasingly communicate CSR initiatives through social media, viral message propagation has become a crucial prerequisite for CSR success. Evidence from two experimental studies, one based on a national representative online sample, shows that social media peers’ endorsement of a CSR message in terms of number of shares, likes and positive replies contributes to an individual’s intention to share it on the social network and thereby participate in message propagation, and that this process can be explained by (...) normative influences exerted by the social media community through the activation of injunctive and descriptive norms, as well as social identity motives. Findings further confirmed that the norm-activating effects of social media endorsement are moderated by the empowering qualities of the CSR message, the sharing source of the message by affecting CSR credibility, and the recipient’s interdependent self-construal. Corporate communication managers are advised to achieve a high degree of initial social media endorsement of their CSR message, for recipients of the message to perceive social pressure motivating message sharing with their social media peers. (shrink)

Construction schedules play an important role in construction project management. However, during construction activities, risks may arise due to unexpected schedule changes, resulting in the ineffective delivery of projects. This study aims to reveal the law of schedule change risk propagation and to analyze the effects on the risk propagation through numerical simulations. First, construction projects are represented by activity-on-node networks. A model of risk propagation is then built based on a susceptible-infected model considering the effects of (...) the nodal characteristics on the propagation process. Next, the model is tested on a real-world project to examine cascading failures with varying parameters. The experimental results demonstrate that the model is effective in identifying the activities most capable of affecting a project schedule and evaluating the impact of schedule change risk propagation. This study will provide a basis for enhancing the robustness of AON networks and controlling the propagation of schedule change risks. (shrink)

A shortage or backlog of inventory can easily occur due to the backward forecasting method typically used, which will affect the normal flow of funds in pharmacies. This paper proposes a replenishment decision model with back propagation neural network multivariate regression analysis methods. With the regular pattern between sales and individual variables, supplemented with the safety stock empirical formula, an accurate replenishment quantity can be obtained. In the case analysis, this paper takes the sales situation of a pharmacy as (...) an example and tests the accuracy and stability of the model. The results show that the model has good prediction accuracy which can be introduced into the intelligent pharmacy system and used in the replenishment of the intelligent pharmacy to prevent overstocking or a shortage of stock, thus improving the financial situation, reducing the manpower burden of typical retail pharmacy, and helping residents buy medicines. (shrink)

Abstract‘Monkey see, monkey do’ is an old saying referring to imitating another's actions without necessarily understanding the underlying motivations or being concerned about consequences, such as propagating harmful behaviors. This study examines the likelihood of firms imitating and proliferating others’ unethical, irresponsible practices thereby exacerbating harmful effects among even more firms; in doing so, irresponsible contagions can rapidly spread more broadly, negatively affecting even more consumers. Building upon rivalry- and information-based imitation theories, we examine if harmful behaviors of others, in (...) combination with misbehavior of referent firms, influences the likelihood of a firm to engage in irresponsible consumer-related practices. After examining 25,824 firm-year observations over 12 years, our findings suggest that imitation of harmful product-related behavior occurs; with size an important factor related to proliferation of harmful behaviors. Testing the model against a holdout sample finds 94% accuracy. Implications for scholars, managers, and policy makers are explored. (shrink)

Since fully covering such a topic in the short space imparted to this paper is an impossible task, I have chosen to focus on three philosophers: Nietzsche, Heidegger and Sartre. Of the three, only the latter was undoubtedly an existentialist ⎯ Heidegger explicitly rejected the categorisation (in the Letter on Humanism), and there is disagreement among commentators about Nietzsche’s status1. However, they have two major common points which justify my focusing on them: firstly, they uphold the primacy of existence over (...) essence. Against the rationalist trend prevalent until the end of the XVIIIth Century, which saw human nature as determined a priori (as rational), all three authors consider human beings as living, self-interpreting entities, whose understanding of themselves is dependent on specific cultural and historical conditions. Given that this self-understanding is taken as constitutive of what it means to be human, it becomes impossible to define the essence of man independently of (let alone prior to) his existence. Secondly (and consequently), they reject the idea that philosophy can start from the study of man as a detached, disembodied consciousness primarily bent on knowing the world ⎯ or even that such a consciousness exists, except as a fiction propagated by rationalism2. Man is viewed as an embodied being, whose reason and cognitive powers are only the visible part of a much deeper and wider engagement with the world. In turn, this rejection of the primacy of rationality and of consciousness explains the central part played by affectivity in our three authors’ works. In all its forms3, affectivity is strongly tied to the body (although existentialist thinkers hold that it is neither identical to nor determined by physical reactions4): once the importance of embodiment has been recognised, an analysis of affectivity becomes necessary to understand the ways in which human beings relate both to themselves and to the world. Whereas the rationalist tradition mostly rejected affectivity5, either on moral grounds (as emotions interfere with self-mastery) or for epistemological reasons (because they cloud the clarity of mind supposedly required by knowledge), Nietzsche, Heidegger and Sartre insist on rehabilitating it, mostly for two reasons: firstly, as it is constitutive of what it means to be human, affectivity just cannot be set aside ⎯ so the rationalist ideal to do away with emotions is unmasked as an illusion, the roots of which need to be investigated.. (shrink)

Delusional mood is a well-recognized psychological state, often present in the prodromal stage of schizophrenia. Various phenomenological psychopathologists have proposed that delusional mood may not only precede but also contribute to the later formation of schizophrenic delusion. Hence, understanding experiential abnormalities involved with the delusional mood have been considered central for the understanding of schizophrenic delusion. Ranging from traditional and contemporary phenomenological and neurobiological accounts, it has been often mentioned that the peculiar affective saliency of the world experience may (...) underpin the emergence of delusional mood. In this paper, I employ Edmund Husserl’s account of affection and affective syntheses to clarify the nature of such an experience and illuminate how this experiential abnormality contributes to the emergence of the delusional mood. I conclude by relating the phenomenological account I advance here with a neurobiological account of aberrant salience hypothesis and chart out a possible way toward mutual enlightenment for both approaches. (shrink)

This is a theoretical treatment of the term "Sha Zhu Pan" (杀猪盘) in Chinese, which translates to “Pig-Butchering” in English. The article critically examines the propagation and validation of "Pig Butchering," an animal metaphor, and its implications for the dehumanisation of victims of online fraud across various discourses. The study provides background information about this type of fraud before investigating its theoretical foundations and linking its emergence to the dehumanisation of fraud victims. The analysis highlights the disparity between academic (...) literature, subjected to rigorous peer-review processes, and sensationalised narratives prevalent in the media. While academic works subject "pig butchering" to critical scrutiny and refrain from endorsing derogatory terms to depict fraud victims, numerous media outlets employ this term uncritically, further worsening the predicament of these victims. "Pig butchering" is firmly rooted in the concept of dehumanisation, and this article underscores how language moulds perceptions of fraud and behaviour, extending to the development of preventive strategies. The role of law enforcement agencies in generating and disseminating materials is also a central theme, emphasising their responsibility as trusted sources of information. We suggest that these agencies should adopt non-victim shaming language to encourage victims to report crimes and alleviate the stigma attached to victimisation. Additionally, the article offers valuable cross-cultural insights by comparing metaphors from Chinese and Nigerian contexts. This comparative analysis enriches our comprehension of the global dimensions of online fraud and its cultural diversities, highlighting the substantial impact of language on perceptions and behaviours. We advocate for a departure from victim-blaming tendencies perpetuated by select media outlets, urging a more compassionate and accurate portrayal of those affected by online fraud. We, therefore, call for a more empathetic and accurate portrayal of individuals affected by online fraud, aligning with the broader objective of promoting understanding and support for these victims. (shrink)

Ion channels play key roles in the generation and propagation of nerve impulses by mediating ionic fluxes across excitable membranes. Elucidation of the structure and function of these proteins is a major goal in understanding the molecular mechanisms of membrane excitability. Much work has focused on sodium channels, whose activity is of primary importance in producing nerve impulses. Despite the recent cloning and sequencing of a sodium channel structural gene, many unanswered questions remain. To address some of these question (...) genetically, Drosophila mutants with altered sodium channels are being isolated and subjected to multidisciplinary analyses. Ultimately, these can provide novel approaches for understanding the function and regulation of sodium channels at a molecular level. (shrink)

This study combines the discovery methods and training of innovative talents, China’s requirements for improving talent training capabilities, and analyses the relationship between the number of professional enrollments in colleges and universities and the demand for skills in specific places. The research learns the characteristics and training models of innovative talents, deep learning, neural networks, and related concepts of the seasonal difference Autoregressive Moving Average Model. These concepts are used to propose seasonal autoregressive integrated moving average back propagation. Firstly, (...) the SARIMA-BP artificially sets the weight parameter values and analyzes the model’s convergence speed, superiority, and versatility. Then, particle swarm optimization algorithm is used to pre-process the model and test its independence. The accuracy of the model is checked to ensure its proper performance. Secondly, the model analyzes and predicts the relationship between the number of professional enrollments of 10 colleges and universities in a specific place and the talent demand of local related enterprises. Moreover, the established model is optimized and tested by wavelet denoising. Independent testing is done to ensure the best possible performance of the model. Finally, the weight value will not significantly affect the model’s versatility obtained by experiments. The prediction results of professional settings and corporate needs reveal that: there is a moderate correlation between professional locations and corporate needs; colleges and universities should train professional talents for local enterprises and eliminate the practical education concepts. (shrink)

Parent-infant emotional expressions vary according to parent and infant gender. Such parent-infant interactions critically affect infant development. Neuroimaging research is exploring emotion-related brain function that varies according to gender, and regulates parenting thoughts and behaviors in the early postpartum. Through specific brain functions, parenting serves to program the infant brain for the next generation of sex-specific emotional expression.

Conceptual engineering is a philosophical method that aims to design and spread conceptual and linguistic devices to cause meaningful changes in the world. So far, however, conceptual engineers have struggled to successfully spread the conceptual and linguistic entities they have designed to their target communities. This paper argues that conceptual engineering is far more likely to succeed if it incorporates empirical data and empirical methods. Because the causal factors influencing successful propagation of linguistic or conceptual devices are as complicated (...) and interwoven as they are, proper empirical research will greatly boost the likelihood that propagation is successful. In arguing for the superiority of empirical conceptual engineering over armchair-based conceptual engineering, this paper proposes a framework for understanding the causal forces at play in propagation. This is a three-part framework between the label of a lexical item, the psychological states associated with the lexical item, and the worldly things associated with the lexical item. By understanding the way causal forces affecting propagation play out at these three levels, conceptual engineers can better conceptualize, study, and harness the different causal forces affecting the success of their conceptual engineering projects. (shrink)

Affection in perception does not exhaust itself in a single subjective act of turning-towards an object. Husserl’s analyses of the propagation of affection in perception, which have not been systematically or thoroughly thematized up until now, offer a much more complex picture of affection, which this article brings to the fore. The affective power distributes itself irregularly in perception. The differentiation of perceptual field into foreground and background prepares the field for the investigation of the distribution of affections. (...) This investigation leads from lower to higher levels of constitution, from simple to complex relations, and from sensations of the lived body to egological factors. In the third section, three directions of propagation of affection and, collectively, six modes of affective awakening are thoroughly analyzed. I end with a discussion of a recent critique of Husserl’s “abstract” approach to affection, which seeks to offer an insight into how a complete theory of affection would look like. (shrink)

This article argues that although post-truth is understood to pose a particular misogynistic threat to feminism, we cannot assume that feminists should simply oppose post-truth. The way the post-truth debate is constructed is problematic for feminism in three ways: it misconceives the relationship between democracy and truth; utilizes a questionable binary between reason and emotion; and propagates elitist assumptions about protecting democracy from the people. Recognizing the insufficiency of our understanding of post-truth, feminists have called for greater understanding of the (...) roles of language, affect and truth in the post-truth debate. In response, I suggest that the theories of Judith Butler and Bonnie Honig can help. However, I seek to emphasise that if feminists are to intervene meaningfully in the inequalities and intensified affective flows that structure the post-truth paradigm they would benefit from a deintensifying, confrontational but nonaggressive, approach. (shrink)

. Underwater communication is usually affected by ambient noise, which may be generated by different sources, such as the wind origin sea-surface sources, ships and under water life. The properties of background noise, which are non-stationary in nature, depend on location, sea depth, wind speed and sound propagation conditions in the area. Overall performance of underwater acoustic instruments can be improved by denoising the underwater signals. This paper proposes a novel denoising method using empirical mode decomposition technique. Frequency domain (...) based thresholding has been used to denoise the signal, which involves three steps: EMD is applied to the noisy signal to decompose the signal into intrinsic mode functions. Thresholding is applied to each IMF in the frequency domain to remove the noise. Thresholded IMFs are added to obtain the denoised signal. Real-time experiments were performed to validate the proposed technique on the basis of the records of the ambient noise data recorded at sea for various wind speed. It was observed that the experimental results are in good agreement with the proposed algorithm under different wind-noise levels. (shrink)

The works of Paul K. Feyerabend, Norwood Russell Hanson and Thomas S. Kuhn have come to occupy a central place in the annals of contemporary philosophy of science. Some of their contemporaries,, tend to regard them as the vanguard of a new “revolutionary” intellectual movement. Reacting against the views of their positivist predecessors, they embrace and propagate the idea that “pervasive presuppositions” are fundamental to scientific investigations. Thus, Feyerabend thinks that, “... scientific theories are ways of looking at the world; (...) and their adoption affects our general beliefs and expectations, and thereby also our experiences and our conception of reality”. This is in stark contrast to the positivist view that the aim of science is the systematization of experience that exists independently of any scientific theories. This new view of scientific theories also involves a “radical” conception of the nature of theoretical change. Rejecting the positivist notion of any constant element through such change, Kuhn regards a basic theoretical change as a conceptual revolution and “wants to say that after a revolution scientists are responding to a different world”. Hanson uses the phrase ‘theory-loaded’ to give expression to a view of the semantic content of observation statements that follows from this general position. (shrink)

​The traditional datum concerning moral testimony is that it is (epistemically or morally) problematic--or at least more problematic--than non-moral testimony. More recently, some have sought to analyze the issue of moral testimony within a narrower lens: instead of questioning whether moral testimony on the whole is (more) problematic or not, they have instead focused on possible conditions under which moral deference would be legitimate or forbidden. In this paper, I consider two such features: that of uncertainty and a belief in (...) the greater reliability of another agent. I argue that under these conditions agents have a moral obligation not to defer. I argue that this is because uncertainty and judgments of others’ reliability covary with social status and are themselves products of oppressive social hierarchies, in which case moral deference under these conditions would result in many harms, the most significant being that it would itself propagate oppression by perpetuating unjust social hierarchies. In this way, this paper focuses on how unjust social facts can affect our moral epistemology, specifically how social and political factors can affect moral testimony, and is thus an exercise in non-ideal moral epistemology. (shrink)

BackgroundResponsive neurostimulation has been utilized as a treatment for intractable epilepsy. The RNS System delivers stimulation in response to detected abnormal activity, via leads covering the seizure foci, in response to detections of predefined epileptiform activity with the goal of decreasing seizure frequency and severity. While thalamic leads are often implanted in combination with cortical strip leads, implantation and stimulation with bilateral thalamic leads alone is less common, and the ability to detect electrographic seizures using RNS System thalamic leads is (...) uncertain.ObjectiveThe present study retrospectively evaluated fourteen patients with RNS System depth leads implanted in the thalamus, with or without concomitant implantation of cortical strip leads, to determine the ability to detect electrographic seizures in the thalamus. Detailed patient presentations and lead trajectories were reviewed alongside electroencephalographic analyses.ResultsAnterior nucleus thalamic leads, whether bilateral or unilateral and combined with a cortical strip lead, successfully detected and terminated epileptiform activity, as demonstrated by Cases 2 and 3. Similarly, bilateral centromedian thalamic leads or a combination of one centromedian thalamic alongside a cortical strip lead also demonstrated the ability to detect electrographic seizures as seen in Cases 6 and 9. Bilateral pulvinar leads likewise produced reliable seizure detection in Patient 14. Detections of electrographic seizures in thalamic nuclei did not appear to be affected by whether the patient was pediatric or adult at the time of RNS System implantation. Sole thalamic leads paralleled the combination of thalamic and cortical strip leads in terms of preventing the propagation of electrographic seizures.ConclusionThalamic nuclei present a promising target for detection and stimulation via the RNS System for seizures with multifocal or generalized onsets. These areas provide a modifiable, reversible therapeutic option for patients who are not candidates for surgical resection or ablation. (shrink)

Perhaps one of the most characteristic aspects of Dewey’s career is that the extent and variety of his work, not to mention his own longevity and his restlessly inquisitive personality, pose a problem to any systematic study of his legacy. At the same time, this “problem” represents the hallmark of his work. Furthermore, Dewey’s works and opinions were propagated and spread in many different formats across many different countries, which makes it only more problematic to study his works, their spread (...) and influence. The first part of this article will present a framework for carrying out a contemporary study on the works of John Dewey, with special attention to the current comeback in interest in them in studies on education. The second part of the article will look into the situation of John Dewey’s legacy in Spanish pedagogy at two fundamental moments in history: the first in the context of the Institución Libre de Enseñanza, the school that led the attempts to modernize education in Spain in the early 1900s. The second moment will focus on studying how the current renewed interest in Dewey has affected contemporary pedagogy in Spain. The article will end by reflecting on what a more integrated reading of Dewey’s pedagogical and philosophical ideas could bring to the theory of education made in Spain. (shrink)

Western culture has been moving away from its Christian roots for several centuries but the turn from Christianity accelerated in the 20th century. At the core of this decline is a loss of a sense of our own transcendence. Scientific materialism has so seriously impacted our belief in human transcendence that many people find it difficult to believe in God and the human soul. This anti-transcendent perspective has not only cast its spell on the natural sciences, psychology, philosophy, and literature, (...) it has also negatively impacted popular culture through the writings of Richard Dawkins, Daniel Dennett, and many others. The warning signs of this loss of transcendence have been expressed by thinkers as diverse as Carl Jung (psychiatrist), Mircea Eliade (historian of religion), Gabriel Marcel (philosopher), C.S. Lewis and J.R.R. Tolkien. These warnings were validated by a 2004 study in the American Journal of Psychiatry which showed that the absence of religion alone was responsible for a marked increase in suicide rates, sense of meaningless, substance abuse, separation from family, and other psychiatric problems. Thus, the loss of transcendence is negatively affecting not only individuals’ sense of happiness, dignity, ideals, virtues, and destiny, but also the culture. Ironically, the evidence for transcendence is greater today than in any other period in history. The problem is – this evidence has not been compiled and propagated. Fr. Spitzer’s book provides a bright light in the midst of this cultural darkness by presenting both traditional and contemporary evidence for God and a transphysical soul from several major sources. He also shows how human consciousness and intelligence is completely special – and cannot be replicated by artificial intelligence or animal consciousness. We are transcendent beings with souls capable of surviving bodily death – self-reflective beings aware of perfect truth, love, goodness, and beauty. We are beings with an unrestricted capacity to know and create science, law, culture, art, music, literature, and so much more. The evidence reveals that we have the dignity of being created in the very image of God, and if we underestimate it, we will undervalue one another, underlive our lives, and underachieve our destiny. This work is the most comprehensive treatment of human transcendence available today. (shrink)

We analyse how memes construct networks of feminist critique and response, mobilising the derisive laughter that energises current feminisms. Using the 2012 case of the ‘Binders Full of Women’ meme, we argue that feminist memes create online spaces of consciousness raising and community building. The timeliness, humorous affect and media techné of meme propagators become significant infrastructures for feminist critique, what we term ‘doing feminism in the network’. If the Internet is particularly good at facilitating the diffusion of feminist jokes, (...) as others argue, we illustrate how the networking and distribution capacities of social media platforms such as Tumblr, Facebook and the online shopping site Amazon.com also cultivate new modes of feminist cultural critique and models of political agency for practising feminism through meme production and propagation. (shrink)

This article describes a representation-based framework of distributed cognition. This framework considers distributed cognition as a cognitive system whose structures and processes are distributed between internal and external representations, across a group of individuals, and across space and time. The major issue for distributed research, under this framework, are the distribution, transformation, and propagation of information across the components of the distributed cognitive system and how they affect the performance of the system as a whole. To demonstrate the value (...) of this representation-based approach, the framework was used to describe and explain an important, challenging, and controversial issue — the concept of affordance. (shrink)

This article describes a representation-based framework of distributed cognition. This framework considers distributed cognition as a cognitive system whose structures and processes are distributed between internal and external representations, across a group of individuals, and across space and time. The major issue for distributed research, under this framework, are the distribution, transformation, and propagation of information across the components of the distributed cognitive system and how they affect the performance of the system as a whole. To demonstrate the value (...) of this representation-based approach, the framework was used to describe and explain an important, challenging, and controversial issue — the concept of affordance. (shrink)

This article describes how a small but vocal group of biomedical scientists propagates the views that either HIV is not the cause of AIDS, or that it does not exist at all. When these views were rejected by mainstream science, this group took its views and arguments into the public domain, actively campaigning via newspapers, radio, and television to make its views known to the lay public. I describe some of the harmful consequences of the group's activities, and ask two (...) distinct ethical questions: what moral obligations do scientists who hold such minority views have with regard to a scientifically untrained lay audience, and what moral obligations do mainstream newspapers and government politicians have when it comes to such views. The latter question will be asked because the 'dissidents' succeeded for a number of years in convincing the South African government of the soundness of their views. The consequences of their stance affected millions of HIV infected South Africans severely. (shrink)

The prestige of science, derived from its claims to certainty, has adversely affected the humanities. There is, in fact, a “politics of certainty”. Our ability to predict events in a limited sphere has been idealized, engendering dangerous illusions about our power to control nature and eliminate time. In addition, the perception and propagation of science as a bearer of certainty has served to legitimate harmful forms of social, sexual, and political power. Yet, as Ilya Prigogine has argued, renewed attention (...) to the irreducible reality of time has brought us to “the end of certainty”. As we enter the age of uncertainty, there is disagreement about how science should be understood and communicated. Some scientists cling to the ideal of certainty, while others emphasize the creative potential of spontaneity, novelty, and surprise. (shrink)

Whenever the state of a biological system is not determined solely by present conditions but depends on its past history, we can say that the system has memory. Bacteria and bacteriophage use a variety of memory mechanisms, some of which seem to convey adaptive value. A genetic type of heritable memory is the programmed inversion of specific DNA sequences, which causes switching between alternative patterns of gene expression. Heritable memory can also be based on epigenetic circuits, in which a system (...) with two possible steady states is locked in one or the other state by a positive feedback loop. Epigenetic states have been observed in a variety of cellular processes, and are maintained by diverse mechanisms. Some of these involve alternative DNA methylation patterns that are stably transmitted to daughter molecules and can affect DNA–protein interactions (e.g., gene transcription). Other mechanisms exploit autocatalytic loops whereby proteins establish the proper conditions for their continued synthesis. Template polymers other than nucleic acids (e.g., components of the cell wall) may also propagate epigenetic states. Non‐heritable memory is exemplified by parasitic organisms that bear a signature of their previous host, such as host‐controlled modification of phage DNA or porin hitchhiking in predatory bacteria. The heterogeneous nature of the examples known may be indicative of widespread occurrence of memory mechanisms in bacteria and phage. However, the actual extent, variety and potential selective value of prokaryotic memory devices remain open questions, still to be addressed experimentally. BioEssays 24:512–518, 2002. © 2002 Wiley Periodicals, Inc. (shrink)

The earliest discoveries of extinct primates and humans profoundly affected the course of evolutionary theory as a scientific model for explaining life and its diversity through time. The absence of such fossils in the early nineteenth century provided important negative evidence to the competing French intellectual schools of Lamarckian evolutionism and Cuvierian catastrophism. Indeed, the first recognition of extinct primates fell serendipitously between the death of Cuvier in 1832 and the revolutionary writings of Darwin in 1859. Largely unknown to history, (...) however, is that four different European scholars, working on three continents, independently discovered and recognized extinct primates within a few months of each other in 1836. The first of these to be formally named, Protopithecus, is ironically the least well known despite being the largest monkey ever discovered in the western hemisphere. The reasons for this forgotten first discovery reflect a general unawareness of South American mammals, and propagation of misinterpretation at a critical time in the history of primatology. (shrink)

Evolution has shaped all living organisms on Earth, although many details of this process are shrouded in time. However, it is possible to see, with one's own eyes, evolution as it happens by performing experiments in defined laboratory conditions with microbes that have suitably fast generations. The longest‐running microbial evolution experiment was started in 1988, at which time twelve populations were founded by the same strain ofEscherichia coli. Since then, the populations have been serially propagated and have evolved for tens (...) of thousands of generations in the same environment. The populations show numerous parallel phenotypic changes, and such parallelism is a hallmark of adaptive evolution. Many genetic targets of natural selection have been identified, revealing a high level of genetic parallelism as well. Beneficial mutations affect all levels of gene regulation in the cells including individual genes and operons all the way to global regulatory networks. Of particular interest, two highly interconnected networks—governing DNA superhelicity and the stringent response—have been demonstrated to be deeply involved in the phenotypic and genetic adaptation of these experimental populations. BioEssays 29:846–860, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

This book explains how limitations in the movement and perception of information constrain human behavior, cognition, interaction, and perspective. How fast can we learn? How much? Why are habits and biases unavoidable? Aspects considered include: how much information can one human absorb in a lifetime? How far does a process of perturbation propagate? How do specialization or generalization, critical thinking or belief, influence what people accomplish? It is aimed at general readers and scientists with an interest in how limitations of (...) the physical sciences affect society and human behavior. (shrink)

Transcranial magnetic stimulation can cause measurable effects on neural activity and behavioral performance in healthy volunteers. In addition, TMS is increasingly used in clinical practice for treating various neuropsychiatric disorders. Unfortunately, TMS-induced effects show large intra- and inter-subject variability, hindering its reliability, and efficacy. One possible source of this variability may be the spontaneous fluctuations of neuronal oscillations. We present recent studies using multimodal TMS including TMS-EMG, TMS-tACS, and concurrent TMS-EEG-fMRI, to evaluate how individual oscillatory brain state affects TMS signal (...) propagation within targeted networks. We demonstrate how the spontaneous oscillatory state at the time of TMS influences both immediate and longer-lasting TMS effects. These findings indicate that at least part of the variability in TMS efficacy may be attributable to the current practice of ignoring oscillatory fluctuations during TMS. Ignoring this state-dependent spread of activity may cause great individual variability which so far is poorly understood and has proven impossible to control. We therefore also compare two technical solutions to directly account for oscillatory state during TMS, namely, to use tACS to externally control these oscillatory states and then apply TMS at the optimal brain state, or oscillatory state-triggered TMS. The described multimodal TMS approaches are paramount for establishing more robust TMS effects, and to allow enhanced control over the individual outcome of TMS interventions aimed at modulating information flow in the brain to achieve desirable changes in cognition, mood, and behavior. (shrink)

When two bodies collide with each other, they change their motion. Many physics textbooks explain that the change in motion is caused by the force or impulse exerted on the body during the collision. This is not the whole story, I argue, in case the bodies are rigid. In this case, the change in motion cannot be causally explained solely by how the bodies are configured before and during the collision but instead should be explained partly by what happens after (...) the collision. That is, the collision between rigid bodies should better be interpreted as a case of retrocausation where the future causally affects the past or present. This retrocausal interpretation of the collision does not suffer a general problem raised against retrocausation, known as the bilking argument. And how the influence of the cause propagates backward in time to the effect in the collision is no more mysterious than how a body moves continuously in classical mechanics or how the future affects the past in proposed retrocausal models for the EPR thought experiment in quantum mechanics. (shrink)

Glial cells play a central role in the development and function of complex nervous systems. Drosophila is an excellent model organism for the study of mechanisms underlying neural development, and recent attention has been focused on the differentiation and function of glial cells. We now have a nearly complete description of glial cell organization in the embryo, which enables a systematic genetic analysis of glial cell development. Most glia arise from neural stem cells that originate in the neurogenic ectoderm. The (...) bifurcation of glial and neuronal fates is under the control of the glial promoting factor glial cells missing. Differentiation is propagated through the regulation of several transcription factors. Genes have been discovered affecting the terminal differentiation of glia, including the promotion glial–neuronal interactions and the formation of the blood–nerve barrier. Other roles of glia are being explored, including their requirement for axon guidance, neuronal survival, and signaling. BioEssays 23:877–887, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

Visual stimuli that are made invisible by masking can affect motor responses to a subsequent target stimulus. When a prime is followed by a mask which is followed by a target stimulus, an inverse priming effect has been found: Responses are slow and frequently incorrect when prime and target stimuli are congruent, but fast and accurate when prime and target stimuli are incongruent. To functionally localize the origins of inverse priming effects, we applied the psychological refractory period paradigm which distinguishes (...) a perceptual level, a central bottleneck, and a level of motor execution. Two dual-task experiments were run with the PRP-paradigm to localize the inverse priming effect relative to the central bottleneck. Together, results of the Effect-Absorption and the Effect-Propagation Procedure suggest that inverse priming effects are generated by perceptual mechanisms. We suggest two perceptual mechanisms as the source of inverse priming effects. (shrink)

The psycho-social day-to-day experience of COVID-19 pandemic has shone some light on the wider scope of health vulnerability and has correspondingly enlarged the ethical debate surrounding the social implications of health and healthcare. This emerging paradigm is neither a single-handed problem of biomedical scientists nor of social analysts. It instead needs a strategically oriented collaborative and interdisciplinary preventive effort. To that effect, this article presents some socio-ethical reflections underscoring the judicious use of the insight from care ethics as an asset (...) in minimizing the possible propagation of the COVID-19 virus and the escalation of its vulnerability in the day-to-day human interaction. It further emphasizes that if this insight is overlooked, the effects of the diverse facets of the “shadow pandemics” of COVID-19—fallouts on both the affected and the infected—may equally be deadly. (shrink)

Epigenetic modifications, such as DNA methylation and post‐translation modifications of histones, have been shown to play an important role in chromatin structure, promoter activity, and cellular reprogramming. Large protein complexes, such as Polycomb and trithorax, often harbor multiple activities which affect histone tail modification. Nevertheless, the mechanisms underlying the deposition of these marks, their propagation during cell replication, and the alteration on their distribution during transformation still require further study. Here we review recent data on those processes in both (...) normal and cancer cells, and we propose that the unscheduled expression of oncogenic transcription factors causes reprogramming of normal cells into cancer stem cells. (shrink)

This paper is concerned with tracing the implications of two ideas as they affect quantum theory. One, which descends from Leibniz and Mach, is that there is no space-time continuum, but that which are involved are spacial and temporal relations involving the distant matter of the universe. The other is that our universe is finite. The picture of the world to which we are led is that of an enormous space-time Feynman diagram whose vertices are events. A consequence of finiteness (...) is that between each pair of events, along a world line, there can be only finitely many intermediate events. A further change is that we are no longer required to believe that particles need be anywhere between events. The paper takes up nonrelativistic quantum theory in a way that is consistent with these ideas. By considering analogies between the Wiener and the Feynman integrals, and between the Wiener process and related discrete processes, there is obtained a straightforward theory for the Feynman integral. Propagators are worked out for many of the cases relevant to the nonrelativistic theory.The paper shows that, even when there are, along each world-line, no more than one event per Compton wavelength, agreement is good with the usual Schrödinger theory. (shrink)

Parkinson's Disease (PD) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. The symptoms generally come on slowly over time. Early in the disease, the most obvious are shaking, rigidity, slowness of movement, and difficulty with walking. Doctors do not know what causes it and finds difficulty in early diagnosing the presence of Parkinson’s disease. An artificial neural network system with back propagation algorithm is presented in this paper for helping doctors in (...) identifying PD. Previous research with regards to predict the presence of the PD has shown accuracy rates up to 93% [1]; however, accuracy of prediction for small classes is reduced. The proposed design of the neural network system causes a significant increase of robustness. It is also has shown that networks recognition rates reached 100%. (shrink)

Visual stimuli that are made invisible by a following mask can nonetheless affect motor responses. To localize the origin of these target priming effects we used the psychological refractory period paradigm. Participants classified tones as high or low, and responded to the position of a visual target that was preceded by a prime. The stimulus onset asynchrony between both tasks varied. In Experiment 1 the tone task was followed by the position task and SOA dependent target priming effects were observed. (...) When the visual position task preceded the tone task in Experiment 2, with short SOA the priming effect propagated entirely to the tone task yielding faster responses to tones on visually congruent trials and delayed responses to tones on visually incongruent trials. Together, results suggest that target priming effects arise from processing before and at the level of the central bottleneck such as sensory analysis and response selection. (shrink)

Recent high-profile corporate scandals are reminiscent of the corporate raider scandals of the 1980s, suggesting that ethical scandals may occur in waves. This article provides a framework for analysis of this question by suggesting that ethical attitudes may be cyclical about long-term secular trends. We provide some empirical evidence from previously published work for the existence of cycles as well as a potential mechanism for their propagation, namely widespread publicity about a particularly salient event, e.g., Enron. Further, we posit (...) that long-run secular trends would be affected through more deliberate, cognitive means, e.g., instruction in business ethics. We also discuss an important research implication, namely that traditional cross-sectional “book-end” studies surveying ethical attitudes at two different points in time may be unable to disentangle short-run cyclical movements from long-term secular trends. (shrink)

The C. elegans male tail is being studied as a model to understand how genes specify the form of multicellular animals. Morphogenesis of the specialized male copulatory organ takes place in the last larval stages during male development. Genetic analysis is facilitated because the structure is not necessary for male viability or for strain propagation. Analysis of developmental mutants, isolated in several functional and morphological screens, has begun to reveal how fates of cells are determined in the cell lineages, (...) and how the specification of cell fates affects the morphology of the structure. Cytological studies in wild type and in mutants have been used to study the mechanism of pattern formation in the tail peripheral nervous system. The ultimate goal is to define the entire pathway leading to the male copulatory organ. (shrink)

Toxic gas leakage has diffusion characteristics and thus dynamically affects surrounding zones. Most of current evacuation traffic management models set the road risk level as a static value, which is related to the distance to the hazard source, or a dynamic value, which is determined by the toxic gas concentration. However, the toxic gas propagation direction is not considered, and this may lead some evacuees driving from less dangerous regions to higher dangerous regions. To address the shortcomings of traditional (...) evacuation traffic management models, this paper proposes an improved road risk level assessment method based on the difference of the risk levels of upstream and downstream zones of road and develops a safer evacuation traffic management model under the diffusion of toxic gas. The Cell Transmission Model is used to depict the evacuation traffic loading process. A numerical test is carried out on Nguyen and Dupuis Network. The test results show that the improved road risk level assessment method can avoid the evacuees driving into higher risk level regions from less dangerous regions. (shrink)

This article explores the relation between innovation and resources that are governed as commons by looking at the governance of potato genetic resources, especially in the context of the emergence ofhybrid diploid potato breedingthat will enable potato propagation through true seeds. As a new breeding tool, hybrid diploid potato breeding may not only revolutionize traditional potato breeding practices, it may also strongly affect current governance modes of potato genetic resources as a commons. Contrary to conventional accounts of the commons (...) that treat technological innovation mainly as an exogenous factor, we argue that technological innovation can better be understood as an endogenous factor. In particular, we develop aco-production frameworkof innovation and the commons that draws attention to the different ways in which innovation, commons and its governance interact. Using this framework, we demonstrate that the constitution of potato genetic resources as a commons cannot be understood without considering the various ways in which technological innovation affects resources and mediate how these are governed. While reversely, technological innovations themselves are also enabled and constrained by users who govern potato genetic resources as a shared resource. We argue that changes in the governance of genetic resources can be understood as a change from one socio-technical constellation to another, whereby innovations, resources, and institutions are continuously co-produced. (shrink)

Aim: The presence of noise in urban environments is rarely considered a factor that causes damage to the environment. The primary generating source is transportation means, with vehicles being the ones that affect cities the most. Traffic noise has a particular influence on the quality of life of those who are exposed to it and can cause health alterations ranging from annoyance to cardiovascular diseases. This study aims to describe the relationship between the traffic noise level and the perceived annoyance (...) in the inhabitants of a city on the Northern Border of Mexico. The work carried out in a city represents the vulnerability characteristics: economic, social, and migratory of its sizable portion of the inhabitants. Due to that, it is impossible to identify precisely the number of residents as the number of vehicles in circulation.Methods: The streets and avenues with an annual average daily traffic of more than 1,000 vehicles were considered for the measurement of traffic noise. The equipment used was a vehicle gauge with non-invasive speed radar; type I integrating sound level meters, with their respective gauges and tripods. A questionnaire was applied to people living within 250 m of the streets and avenues in which the noise was measured.Results: The noise measurement found a parameter of LAeq estimated for 12 h during the day, exceeding 70 dBA. The data received from the questionnaire were statistically tested by using Pearson's correlation tests. A total number of 2,350 people were participated, of whom 1,378 were women and 972 were men. The age of participants is ranged from 18 to 75 years. The overall perception of traffic noise annoyance identified that 1,131 participants responded “Yes” as they considered the noise annoying. Participants who responded “No” as well as those who responded “Do not know” resulted in a total of 1,219 people.Conclusion: The results show that the population is desensitized to traffic noise and does not perceive it as an annoyance. The flow of vehicles and the type of vehicles are the significant factors for the propagation and increase in the traffic noise levels. Women present a considerable appreciation of traffic noise perception instead of younger people who demonstrate a higher tolerance to high-level exposure. This reflects the lack of information of the population around the noise problem and its effects. (shrink)

Neurons encode and transmit signals through chemical synaptic or electrical synaptic connections in the actual nervous system. Exploring the biophysical properties of coupling channels is of great significance for further understanding the rhythm transitions of neural network electrical activity patterns and preventing neurological diseases. From the perspective of biophysics, the activation of magnetic field coupling is the result of the continuous release and propagation of intracellular and extracellular ions, which is very similar to the activation of chemical synaptic coupling (...) through the continuous release of neurotransmitters. In this article, an induction coil is used to connect two HR neurons to stimulate the effect of magnetic field coupling. It is inevitable that time delays can affect the coupling process in the transmission of information, and it should be considered in the coupled model. Firstly, the firing characteristics and bifurcation modes of two coupled HR neurons are studied by using one parameter and two parameters bifurcation. With the increase of propagation delay and coupling gain, the chaotic state of neurons disappears and the high-period window decreases due to the influence of energy transfer between neurons. Then, the synchronization patterns of two HR neurons with different stimulation are analyzed by error diagrams and time series diagrams. It is confirmed that the synchronous pattern has certain regularity and is related not only to the neurons with large stimulation current but also to the time delay and coupling gain. The research conclusions of this article will provide the corresponding theoretical basis for medical experiments. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Philosophy 38.4 (2000) 529-548 [Access article in PDF] Shaftesbury's Two Accounts of the Reason to be Virtuous Michael B. Gill College of Charleston 1. Anthony Ashley Cooper, the third Earl of Shaftesbury (1671-1713), was the founder of the moral sense school, or the first British philosopher to develop the position that moral distinctions originate in sentiment and not in reason alone. Shaftesbury thus struck (...) the initial blow in the battle waged by sentimentalists such as Hutcheson and Hume against rationalists such as Cudworth and Clarke.Such is a common view of Shaftesbury's place in the history of moral philosophy.1 But while this common view is accurate in a very general sense, it also oversimplifies in a manner that threatens to misrepresent the development of modern ethical theory and obscure what is most interesting about Shaftesbury.2 The view suggests, in particular, that the most important distinction in early modern British moral philosophy was between sentimentalism and rationalism. There was, however, a distinction ontologically deeper than [End Page 529] that, which explains how Shaftesbury, even while developing his moral sense theory, could at times be much closer to his rationalist predecessors Cudworth and Clarke than to his sentimentalist followers Hutcheson and Hume.In this paper I will elucidate this deeper ontological distinction by examining two different accounts that Shaftesbury gives of the reason to be virtuous. Both of Shaftesbury's accounts are in a sense sentimentalist, but only the second of them constitutes a sharp break from his rationalist predecessors. Shaftesbury himself does not seem fully aware of the radical implications of his second account, but the implications are there nonetheless. And by exposing them we will gain a view not only of a crucial ambiguity in Shaftesbury's thought but also of a central faultline in the history of British moral philosophy. We will also come to see that while Shaftesbury does pave the way for a new ontology of morals, he does so more by accident than by design.3 2. Shaftesbury believes that to be virtuous is to have a benevolent character or a deep non-derivative commitment to promote the "publick Interest."4 He also believes that a person who has a benevolent character will always be happier than a person who does not, and that this constitutes a sufficient reason for each of us to "embrace" virtue (Inquiry 48).5 But of course some will deny that the benevolent person is always happiest and so Shaftesbury sets out to prove that there exists between benevolence and happiness a natural and necessary connection.How does Shaftesbury establish the connection between benevolence and happiness? In two different ways.6 The first way of establishing the connection [End Page 530] can be called the teleological account, and the second way can be called the mental enjoyment account. Let us first examine the teleological account.The initial claim of Shaftesbury's teleological account of the reason to embrace virtue is that benevolence is what is most natural for humans, or their proper end or telos.7 As he puts it just after explaining "whatVirtueis," It has been already shewn, that in the Passions and Affections of particular Creatures, there is a constant relation to the Interest of a Species, or common Nature. This has been demonstrated in the case of natural Affection, parental Kindness, Zeal for Posterity, Concern for the Propagation and Nurture of the Young, Love of Fellowship and Company, Compassion, mutual Succour, and the rest of this kind. Nor will any-one deny that this Affection of a Creature towards the Good of the Species or common Nature, is as proper and natural to him, as it is to any Organ, Part or Member of an Animal-Body, or mere Vegetable, to work in its known Course, and regular way of Growth. 'Tis not more natural for the Stomach to digest, the Lungs to breathe, the Glands to separate juices, or other Intrails to perform their several Offices; however they may by particular Impediments... (shrink)

The possibility of seeding other planets with life poses a tricky dilemma. On the one hand, directed panspermia might be extremely good, while, on the other, it might be extremely bad depending on what factors are taken into consideration. Therefore, we need to understand better what is ethically at stake with planetary seeding. I map out possible conditions under which humanity should spread life to other solar systems. I identify two key variables that affect the desirability of propagating life throughout (...) the galaxy. The first is axiological and depends on which value theory in environmental ethics is correct. The second is empirical and depends on whether life is common or not in our region of the universe. I also consider two ethical objections to an interplanetary life-seeding mission: the risk of interfering with indigenous life and the risk of increasing suffering in our galaxy. (shrink)

For manufacturing enterprises to successfully enter the “Industry 4.0” era and establish advantages in the new wave of the Industrial Revolution, they must use Internet thinking to transform manufacturing enterprises and promote the in-depth integration of informatization and industrialization under the premise of managing and controlling risks, to achieve transformation and upgrading. Research on and management of the risks of manufacturing enterprises’ Internet strategic transformation directly affects the success or failure of enterprises’ transformation. This study constructed a risk evaluation model (...) for a manufacturing enterprise’s Internet strategic transformation based on the back propagation artificial neural network and conducted a case study on one enterprise. (shrink)

The accurate positioning of target is an important link in robot technology. Based on machine learning algorithm, this study firstly analyzed the location positioning principle of binocular vision of robot, then extracted features of the target using speeded-up robust features (SURF) method, positioned the location using Back Propagation Neural Networks (BPNN) method, and tested the method through experiments. The experimental results showed that the feature extraction of SURF method was fast, about 0.2 s, and was less affected by noise. (...) It was found from the positioning results that the output position of the BPNN method was basically consistent with the actual position, and errors in X, Y and Z directions were very small, which could meet the positioning needs of the robot. The experimental results verify the effectiveness of machine learning method and provide some theoretical support for its further promotion and application in practice. (shrink)