Microscopy allows us to observe objects we cannot see with our eyes alone. With a light microscope, we can distinguish objects at the scale of the wavelengths of visible light just under a micrometer. Around 1870 Ernst Abbe, who laid the foundation of modern optics, suggested that the resolution of a microscope would improve by using some yet-unknown radiation with shorter wavelengths than visible light, that is, below 390 nanometers (1 nm = 10−9 m). Electrons can have wavelengths near 1 (...) picometer (1 pm = 10−12 m) and should therefore allow atoms to be distinguished since they are typically at least a few hundred pm apart. In this oversimplified view, further decreasing the wavelength of the radiation should allow us to increase the resolution of electron microscopy even more. However, this can only be done by increasing the energy of the radiation, which would ultimately destroy the samples. Other factors also affect the resolution of electron microscopes, among them non-ideal imaging properties of electromagnetic lenses, which result in false images. It took more than half a century to understand and control these aberrations and separate objects less than 1 Ångstrom (1 Å = 10−10 m) apart. (shrink)

Cancer biology features the ascription of normal functions to parts of cancers. At least some ascriptions of function in cancer biology track local normality of parts within the global abnormality of the aberration to which those parts belong. That is, cancer biologists identify as functions activities that, in some sense, parts of cancers are supposed to perform, despite cancers themselves having no purpose. The present paper provides a theory to accommodate these normal function ascriptions—I call it the Modeling Account (...) of Normal Function (MA). MA comprises two claims. First, normal functions are activities whose performance by the function-bearing part contributes to the self-maintenance of the whole system and, thereby, results in the continued presence of that part. Second, MA holds that models of system-level activities that are (partly) constitutive of self-maintenance are improved by including a representation of the relevant function-bearing part and by making reference to the activity/activities that part performs which contribute(s) to those system-level activities. I contrast MA with two other accounts that seek to explicate the ascription of normal functions in biology, namely, the organizational account and the selected effects account. Both struggle to extend to cancer biology. However, I offer ecumenical readings which allow them to recover some ascriptions of normal function to parts of cancers. So, though I contend that MA excels in this respect, the purpose of this paper is served if it provides materials for bridging the gap between cancer biology, philosophy of cancer, and the literature on function. (shrink)

Aberrant Nuptials' explores the diversity and richness of the interactions between artistic research and Deleuze studies. "Aberrant nuptials" is the expression Gilles Deleuze uses to refer to productive encounters between systems characterised by fundamental difference. More than imitation, representation, or reproduction, these encounters foster creative flows of energy, generating new material configurations and intensive experiences. Within different understandings of artistic research, the contributors to this book - architects, composers, film-makers, painters, performers, philosophers, sculptors, and writers - map current practices at (...) the intersection between music, art, and philosophy, contributing to an expansion of horizons and methodologies. Written by established Deleuze scholars who have been working on interferences between art and philosophy, and by musicians and artists who have been reflecting Deleuzian and Post-Deleuzian discourses in their artworks, this volume reflects the current relevance of artistic research and Deleuze studies for the arts. (shrink)

The issue of realism about the physical world is distinct from the semantic issue of correspondence truth. So it is an aberration to identify the two issues (Dummett), to dismiss the realism issue out of hostility to correspondence truth (Rorty, Fine), to think that that issue is one of interpretation, or to argue against realism by criticizing various claims about truth and reference (Putnam, Laudan). It is also an aberration to identify realism with nonskepticism, truth-as-the-aim-of-science, or scientific convergence. (...) Realism is an overarching metaphysical issue which should be settled before any of these epistemic and semantic issues. (shrink)

One of the first comprehensive treatments of Deleuzian thought. There is always something schizophrenic about logic in Deleuze, which represents another distinctive characteristic: a deep perversion of the very heart of philosophy. Thus, a preliminary definition of Deleuze's philosophy emerges: an irrational logic of aberrant movements. —from Aberrant Movements In Aberrant Movements, David Lapoujade offers one of the first comprehensive treatments of Deleuzian thought. Drawing on the entirety of Deleuze's work as well as his collaborations with Félix Guattari, from the (...) “transcendental empiricism” of Difference and Repetition to the schizoanalysis and geophilosophy of Anti-Oedipus and A Thousand Plateaus, Lapoujade explores the central problem underlying the delirious coherence of Deleuze's philosophy: aberrant movements. These are the movements that Deleuze wrests from Kantian idealism, Nietzsche's eternal return, and the nonsense of Lewis Carroll; they are the schizophrenic processes of the unconscious and the nomadic line of flight traversing history—in short, the forces that permeate life and thought. Tracing and classifying their “irrational logics” represent the quintessential tasks of Deleuzian philosophy. Rather than abstract notions, though, these logics constitute various modes of populating the earth—involving the human as much as the animal, physical, and chemical—and the affective, mental, and political populations that populate human thought. Lapoujade argues that aberrant movements become the figures in a combat against the forms of political, social, philosophical, aesthetic, and scientific organization that attempt to deny, counter, or crush their existence. In this study of a thinker whose insights, theoretical confrontations, and perverse critiques have profoundly influenced philosophy, literature, film, and art over the last fifty years, Lapoujade invites us to join in the discordant harmonies of Deleuze's work—and in the battle that constitutes the thought of philosophy, politics, and life. (shrink)

The “classic” is a vexed term in the work of William Carlos Williams. He uses the category to describe both the stale classicism of T. S. Eliot and Ezra Pound and, conversely, the authentic, “aberrant” classic of James Joyce and surrealism. Analyzing unpublished archival manuscripts alongside the posthumously published collection of essays, The Embodiment of Knowledge, I approach the classic through Williams's theories of pedagogy. Williams parodies and rejects academic modes of reading that cling to the “malignant rigidities” of the (...) past. Yet Paterson and The Embodiment also theorize the reader's interpretive power to disrupt any homogenizing conformity latent in the literary tradition. This dissonant hermeneutics can recuperate the classics and represents a form of resistance to a binary logic of past versus present, or European versus American literature. (shrink)

Summary The twofold objective of this study is (1) to identify and give a brief review of the historical development of the various designs of early (pre-1850) telescope eyepieces, and (2) to determine by measurements and calculations the axial and lateral chromatic aberrations of a number of extant eyepieces from that period in order to provide basic data on which to judge the relative quality of different eyepiece forms. Eight distinct types of eyepieces containing one to five lens elements are (...) discussed and illustrated. The second objective was addressed by measuring the focal lengths of the individual lens elements and the lens spacings in each eyepiece. The data were processed by a ray-tracing program that yields the chromatic aberration (CA) and focal length of each of the eyepieces. Twenty-one telescopes from that period were studied in this way. Similar calculations were also made using data available in the literature on several additional historic telescopes. The conclusions drawn from the data are: (1) Telescopes with Galilean eyepieces have a smaller CA than those with Keplerian or Huygens eyepieces. (2) The two-lens Keplerian terrestrial eyepieces are demonstrated to have larger axial and lateral CA than any of the other eyepiece types. (3) Calculations from examples of telescopes by Divini and Campani for which data were available indicate that while the axial CAs of the two were the same, Campani's instrument had a much smaller lateral CA. (4) Five element eyepieces were found to be better corrected for CA than the early four-lens systems that replaced them. (5) This study tends to confirm the speculation that the reason makers of early achromatic telescopes overcorrected the objective lenses was to compensate for the CA of the eyepieces. (shrink)

IntroductionIdeas of reference are frequent in psychopathology, mainly in psychotic disorders. The frequency of IR and preoccupation about them are related to the psychotic dimension, and to a lesser extent, to negative or emotional disorganized dimensions. Aberrant salience, has been proposed as an indicator of the onset of psychosis, particularly of schizophrenia. This study analyzed the mediating role of AS, disorganized symptoms and preoccupation about IR in the relationship between IR and the psychotic dimension.MethodThe sample consisted of 330 participants, 62.4% (...) of whom were women aged 18–79. The Referential Thinking Scale, the Aberrant Salience Inventory, and the Brief Psychiatric Rating Scale were administered.ResultsEvidence of a partial mediation model showed that the relationships between IR and the psychotic dimension were mediated jointly by AS and the disorganized dimension, and preoccupation about IR no longer had a role. This relationship was significantly influenced by participant age. The variables in the model explained 54.16% of the variance.ConclusionThe model proposed enabled a set of vulnerabilities to be predicted that could lead to a high-risk general pathological state and proneness to psychosis in particular. These findings are discussed with regard to early detection and prevention of psychosis. (shrink)

Uttered language does not necessarily reflect the planned communications of schizophrenia patients, nor do their delusions necessarily reflect basic failures of inferential reasoning. The role of inhibitory failure in the production of speech and the role of primary experiences of discrepancy between intention and action, and between experience–based expectations and perceived realities account for many of the clinical phenomena that have led to the conclusion that these patients have a ‘thought’ disorder, or a ‘disturbed’ mind. The alternatives and the evidence (...) are summarized in this paper. (shrink)

Male sexual arousal (SA) has been known as a multidimensional experience involving closely interrelated and coordinated neurobehavioral components that rely on widespread brain regions. Recent functional neuroimaging studies have shown relation between abnormal/altered dynamics in these circuits and male sexual dysfunction. However, alterations in the topological1 organization of structural brain networks in male sexual dysfunction are still unclear. Here, we used graph theory2 to investigate the topological properties of large-scale structural brain networks, which were constructed using inter-regional correlations of cortical (...) thickness between 78 cortical regions (subcortical regions were not included due to the used cortical surface model) in 40 patients with psychogenic erectile dysfunction (pED) and 39 normal controls. Compared with normal controls, pED patients exhibited a less optimal global topological organization with reduced global and increased local efficiencies. Our results suggest disrupted neural integration among distant brain regions in pED patients, consistent with previous reports of impaired white matter structure and abnormal functional integrity in pED. Additionally, disrupted global network topology in pED was observed to be primarily relevant to altered subnetwork and nodal properties within the networks mediating the cognitive, motivational and inhibitory processes of male SA, possibly indicating disrupted integration of these networks in the whole brain networks and might account for pED patients’ abnormal cognitive, motivational and inhibitory processes for male SA. In total, our findings provide evidence for disrupted integrity in large-scale brain networks underlying the neurobehavioral processes of male SA in pED and provide new insights into the understanding of the pathophysiological mechanisms of pED. (shrink)

Summary The twofold objective of this study is (1) to identify and give a brief review of the historical development of the various designs of early (pre-1850) telescope eyepieces, and (2) to determine by measurements and calculations the axial and lateral chromatic aberrations of a number of extant eyepieces from that period in order to provide basic data on which to judge the relative quality of different eyepiece forms. Eight distinct types of eyepieces containing one to five lens elements are (...) discussed and illustrated. The second objective was addressed by measuring the focal lengths of the individual lens elements and the lens spacings in each eyepiece. The data were processed by a ray-tracing program that yields the chromatic aberration (CA) and focal length of each of the eyepieces. Twenty-one telescopes from that period were studied in this way. Similar calculations were also made using data available in the literature on several additional historic telescopes. The conclusions drawn from the data are: (1) Telescopes with Galilean eyepieces have a smaller CA than those with Keplerian or Huygens eyepieces. (2) The two-lens Keplerian terrestrial eyepieces are demonstrated to have larger axial and lateral CA than any of the other eyepiece types. (3) Calculations from examples of telescopes by Divini and Campani for which data were available indicate that while the axial CAs of the two were the same, Campani's instrument had a much smaller lateral CA. (4) Five element eyepieces were found to be better corrected for CA than the early four-lens systems that replaced them. (5) This study tends to confirm the speculation that the reason makers of early achromatic telescopes overcorrected the objective lenses was to compensate for the CA of the eyepieces. (shrink)

Drugs targeting a single TK/RTK in the treatment of solid cancers has not had the same success seen in blood cancers. This is, in part, due to acquired resistance in solid cancers arising from a range of mechanisms including the upregulation of compensatory RTK signalling. Rather than attempting to inhibit individual compensatory RTK—requiring knowledge of which RTKs are upregulated in any given tumour—strategies to universally inhibit signalling from multiple RTKs may represent an effective alternative. Endosomal trafficking of RTKs is a (...) common conduit that can regulate signalling from multiple RTKs simultaneously. As such, we posit that targeting endosomal trafficking—in particular, aberrant post‐translational modifications in cancers that contribute to dysregulated endosomal trafficking—could inhibit oncogenic signalling driven by multiple RTKs and pave the way for the development of a novel class of inhibitors that shift the trafficking of RTKs to inhibit tumour growth. (shrink)

We describe our explicit Lorentz-invariant solution of the Einstein and null geodesic equations for the deflection experiment of 2002 September 8 when a massive moving body, Jupiter, passed within 3.7’ of a line-of-sight to a distant quasar. We develop a general relativistic framework which shows that our measurement of the retarded position of a moving light-ray deflecting body (Jupiter) by making use of the gravitational time delay of quasar’s radio wave is equivalent to comparison of the relativistic laws of the (...) Lorentz transformation for gravity and light. Because, according to Einstein, the Lorentz transformation of gravity field variables must depend on a fundamental speed c, its measurement through the retarded position of Jupiter in the gravitational time delay allows us to study the causal nature of gravity and to set an upper limit on the speed of propagation of gravity in the near zone of the solar system as contrasted to the speed of the radio waves. In particular, the v/c term beyond of the standard Einstein’s deflection, which we measured to 20% accuracy, is associated with the aberration of the null direction of the gravity force (“aberration of gravity”) caused by the Lorentz transformation of the Christoffel symbols from the static frame of Jupiter to the moving frame of observer. General relativistic formulation of the experiment identifies the aberration of gravity with the retardation of gravity because the speed of gravitational waves in Einstein’s theory is equal to the speed of propagation of the gravity force. We discuss the misconceptions which have inhibited the acceptance of this interpretation of the experiment. We also comment on other interpretations of this experiment by Asada, Will, Samuel, Pascual–Sánchez, and Carlip and show that their “speed of light” interpretations confuse the Lorentz transformation for gravity with that for light, and the fundamental speed of gravity with the physical speed of light from the quasar. For this reason, the “speed of light” interpretations are not entirely consistent with a retarded Liénard–Wiechert solution of the Einstein equations, and do not properly incorporate how the phase of the radio waves from the quasar is perturbed by the retarded gravitational field of Jupiter. Although all of the formulations predict the same deflection to the order of v/c, our formulation shows that the underlying cause of this deflection term is associated with the aberration of gravity and not of light, and that the interpretations predict different deflections at higher orders of v/c beyond the Shapiro delay, thus, making their measurement highly desirable for deeper testing of general relativity in future astrometric experiments like Gaia, SIM, and SKA. (shrink)

This book offers an analysis of the ways a linked set of ethico-political concepts - responsibility, rights, freedom, equality, and justice - might be re-thought, in view of the linguistic deconstruction of their underlying principle, the individual human subject. In a series of readings of contemporary thinkers and their philosophical antecedents the author argues that an encounter with the difficulties of reading language, precisely what resists the immediate comprehension or mastery of a subject, enables in turn a new thought of (...) rights and responsibility. The book is driven by a sense that literary and theoretical questions, and the ideas or concepts they appeal to or provoke, play a critical role in the way we think about and experience politics. The author seeks to harness this specialized discourse in order to consider what ethical and political thinking might learn from literature and its theorists. (shrink)

Children with autism spectrum disorder show marked difficulties in reading comprehension, a complex cognitive skill fundamental to successful daily functioning that is associated with core executive functions. However, the neurophysiological mechanisms underlying reading comprehension deficits in these children remain elusive. Twenty-one right-handed males with high-functioning ASD and 23 age-, IQ-, educational level-, sex- and handedness-matched typically developing individuals underwent a reading comprehension test and the semantic verbal fluency test that tapped core executive functions underlying reading comprehension during concurrent prefrontal functional (...) near-infrared spectroscopy measurement. Participants’ information processing efficiency was also assessed. High-functioning ASD children exhibited general reading comprehension [main effect of group: F = 7.58, p = 0.009], selective verbal fluency deficits [Group × category interaction: F = 4.90, p = 0.032] and slower processing speed. Regarding the hemodynamics of the prefrontal cortex, although ASD individuals showed comparable patterns of PFC brain activation to their healthy counterparts, lower PFC intrahemispheric [main effect of group: F = 11.36, p = 0.002] and interhemispheric [main effect of group: F = 7.79, p = 0.008] functional connectivity were evident during the semantic verbal fluency test. At the whole-group level, poorer reading comprehension performance was associated with poorer performance in the semantic verbal fluency test. Moreover, poorer semantic verbal fluency test performance was associated with slower information processing speed, which is associated with reduced left medial PFC functional connectivity. Abnormal intrahemispheric and interhemispheric prefrontal hypoconnectivity is associated with deficits in executive processes essential for reading comprehension in ASD. Our study has provided important implications for the neuropsychological and neurophysiological mechanisms underlying reading comprehension deficits in ASD. (shrink)

This article examines the disappearance of Malaysian Airlines MH370 through the lens of its varied non-human witnesses. By employing Harun Farocki’s notion of operative images in conjunction with the process philosophy of Alfred North Whitehead it plots a radically dispersed and autonomous image-making apparatus that captured the event of the aircraft’s disappearance and accelerated the expansion of the event itself. Crucially, this article proposes that these images cannot be understood in terms of vision but must be read instead as a (...) series of tactile or synaesthetic practices between materials. Through examining contemporary image-making technologies employed in the search for the aircraft, it charts an ontological tactility within image making, one that – it is argued – has been present since the birth of the medium itself. (shrink)

In general, in our ordinary life, we manage to make the difference between “strange” behavior and error or extravagant beliefs. The question is here to know how we do so, and against what background. There are also specialized contexts for evaluating whether certain types of behavior or discourse are normal or abnormal: courts of law and psychiatric hospitals are two examples. In these contexts, judgments are formed against a background of technical or scientific knowledge, but they also result from epistemic (...) means of evaluation that are similar to habitual ones. The paper seeks to highlight this similarity with respect to recognizing mental disturbance. Starting from Wittgenstein’s On Certainty, it attempts at extending it by drawing on notions of reciprocal perspectives and of judgments of incongruity. It documents its investigation by analyzing sequences from Malek Bensmail’s documentary, Aliénations, which examines the treatment of mental suffering in contemporary Algeria. (shrink)

Religion has been a part of sociopolitical movements from the dawn of history. With a strong emphasis on morality, religion and religious people were expected to live an exemplary life in society. Thus, religion is a veritable tool for shaping and stirring of the human society. However, religion has placed immense stress on public discourse as the literature on the manipulation of religion by religious leaders for their personal gain and aggrandisement is scanty. This research intends to fill this gap. (...) The theoretical framework of this study is functionalism. It adopts a qualitative research approach. The data was derived mainly from primary and secondary sources. The discussions in this article expose the religious impropriety in Nigerian society, which includes intolerance, hypocrisy, commercialisation of religion, manipulation and exploitation of the adherents, subjecting them to laziness, frustration, desperation and poverty. This alters individual rights and personal development, which are deterrents to progress and oppose the religious tenets of holiness, truthfulness and sacredness. This article advocates good religious values for good behaviour to enhance the social structure and boost societal development. CONTRIBUTION: This contemporary time in Nigeria is the era of religious explosion, where there are uncountable new religious faiths and groups. Religious practices in Nigeria are commercialised. Church leaders have abandoned the precepts on which the Church and other religious practices are founded to pursue economic or commercial-oriented interests and tendencies. (shrink)

ObjectiveType 2 diabetes mellitus (T2DM) is a high risk of cognitive decline and dementia, but the underlying mechanisms are not yet clearly understood. This study aimed to explore the functional connectivity (FC) and topological properties among whole brain networks and correlations with impaired cognition and distinguish T2DM from healthy controls (HC) to identify potential biomarkers for cognition abnormalities.MethodsA total of 80 T2DM and 55 well-matched HC were recruited in this study. Subjects’ clinical data, neuropsychological tests and resting-state functional magnetic resonance (...) imaging data were acquired. Whole-brain network FC were mapped, the topological characteristics were analyzed using a graph-theoretic approach, the FC and topological characteristics of the network were compared between T2DM and HC using a general linear model, and correlations between networks and clinical and cognitive characteristics were identified. The support vector machine (SVM) model was used to identify differences between T2DM and HC.ResultsIn patients with T2DM, FC was higher in two core regions [precuneus/posterior cingulated cortex (PCC)_1 and later prefrontal cortex_1] in the default mode network and lower in bilateral superior parietal lobes (within dorsal attention network), and decreased between the right medial frontal cortex and left auditory cortex. The FC of the right frontal medial-left auditory cortex was positively correlated with the Montreal Cognitive Assessment scales and negatively correlated with the blood glucose levels. Long-range connectivity between bilateral auditory cortex was missing in the T2DM. The nodal degree centrality and efficiency of PCC were higher in T2DM than in HC (P < 0.005). The nodal degree centrality in the PCC in the SVM model was 97.56% accurate in distinguishing T2DM patients from HC, demonstrating the reliability of the prediction model.ConclusionFunctional abnormalities in the auditory cortex in T2DM may be related to cognitive impairment, such as memory and attention, and nodal degree centrality in the PCC might serve as a potential neuroimaging biomarker to predict and identify T2DM. (shrink)

In the course of reading David Lapoujade’s Aberrant Movements, readers will undoubtedly encounter its overtly nuanced positioning. In relation to the existent patterns of critical engagement with Deleuze’s works, Lapoujade chooses to make his book seem like an expressive tissue of an expanding poetic universe rather than a measurable extensity from some representational whole. So the potency of his book, as Rajchman makes evident in the ‘Introduction’ to Aberrant Movements, doesn’t lie in unfolding like a teleological mimicry of what stands (...) before us as some kind of palimpsestic accretion of a-categorical Deleuzean readings. Rather his work is a perversely creative exercise in repeating these readings into openings of inassimilable differences. Such an inclusively ‘exclusive positioning’ of his book brings about what we may call a transformative de-familiarization of it, rendering it as indistinct patterns of aberrant movements that continuously and creatively shift us from one kind of complex territorial intensity to another. (shrink)

Pourquoi intituler cette étude : Deleuze, les mouvements aberrants? C'est que, au premier abord, sa philosophie - et celle construite avec Félix Guattari - se présentent comme une sorte d'encyclopédie de mouvements aberrants. C'est ce qu'il a cherché dans le cinéma, dans la peinture, la littérature, les sciences, dans l'histoire des sociétés, dans la philosophie, et partout. Ainsi par exemple, les déformations des figures de Francis Bacon, les non-sens de Lewis Carroll, les lignes destructrices et créatrices des populations nomades à (...) travers l'histoire, la démence du système capitaliste, les processus schizophréniques qui forment l'inconscient, toutes les forces qui traversent la vie et la pensée. Voilà ce qu'il faut d'abord expliquer : la présence de ces mouvements aberrants Mais on ne peut pas s'en tenir là. La philosophie ne peut pas se contenter de les décrire ou d'en dresser la carte, elle doit rendre raison de ces mouvements. D'où un deuxième aspect, tout aussi important : il faut produire les logiques irrationnelles de ces mouvements aberrants. C'est l'une des grandes nouveautés de l'oeuvre de Deleuze et Guattari : créer de nouvelles logiques, loin des modèles rationnels classiques, mais aussi loin de modèles contemporains, comme le marxisme ou le structuralisme orthodoxes des années 1960-1980. Mais ces logiques n'ont rien d'abstrait, au contraire : ce que veulent faire Deleuze et Guattari, c'est dégager les logiques de tous les modes de peuplements de la terre. Par peuplement, il ne faut pas seulement entendre les populations humaines, mais les populations géologiques, animales, cosmiques ou encore les populations mathématiques, esthétiques, philosophiques qui peuplent la pensée des hommes. Quelle est la logique de tous ces peuplements? Poser une telle question, ce n'est pas seulement demander des explications, mais exiger des justifications. Par exemple, pour le capitalisme : de quel droit se déploie-t-il sur la terre? De quel droit s'approprie-t-il nos cerveaux pour le peupler d'images et de sons? De quel droit asservit-il les corps? Aux logiques que le capitalisme met en oeuvre, ne faut-il pas opposer d'autres logiques, celles justement des mouvements aberrants? Dès lors, la philosophie devient inséparable de combats contre toutes les formes d'organisation - politique, sociale, philosophique, esthétique, scientifique - qui tentent de nier, de conjurer, d'écraser l'existence de ces mouvements aberrants. Ce sont ces questions que cette étude examine, en proposant une traversée de toute la philosophie de Deleuze. (shrink)