The Myelin Regulator Factor (MYRF) is a master regulator governing myelin formation and maintenance in the central nervous system. The conservation of MYRF across metazoans and its broad tissue expression suggest it has functions extending beyond the well‐established role in myelination. Loss of MYRF results in developmental lethality in both invertebrates and vertebrates, and MYRF haploinsufficiency in humans causes MYRF‐related Cardiac Urogenital Syndrome, underscoring its importance in animal development; however, these mechanisms are largely unexplored. MYRF, an unconventional transcription factor, begins (...) embedded in the membrane and undergoes intramolecular chaperone mediated trimerization, which triggers self‐cleavage, allowing its N‐terminal segment with an Ig‐fold DNA‐binding domain to enter the nucleus for transcriptional regulation. Recent research suggests developmental regulation of cleavage, yet the mechanisms remain enigmatic. While some parts of MYRF's structure have been elucidated, others remain obscure, leaving questions about how these motifs are linked to its intricate processing and function. (shrink)

In this paper, I first seek a relatively plausible formulation of the safety principle. To this end, I refute a recent form of safety by Duncan Pritchard and then defend another weaker form of safe...

To make the interface design of computer application system better, meet the psychological and emotional needs of users, and be more humanized, the emotional factor is increasingly valued by interface designers. In the design of human-computer interaction graphical interfaces, the designer attaches great importance to the emotional design of the interface, and enhances the humanized design of the interface, which cannot only improve the comfort of the interface, but also improve the fun of the interface, to ensure the psychological and (...) emotional needs of users can be better satisfied. It may acquire information that is favorable to innovative design by utilizing cluster analysis algorithm to tackle the problem of complicated cultural information, and then utilize cellular genetic algorithm to carry out creative design of cultural items. It increases the availability of cultural and creative goods. The classic cluster analysis technique offers the maximum data clustering effect of 53.3%, according to the findings of this paper’s experiments. While the improved cluster analysis algorithm has the highest data clustering effect of 90%. It can be seen that the improved cluster analysis algorithm can effectively perform cluster analysis on a large amount of data in cultural and creative products. It thus finds out the most suitable designer’s creative information, which helps designers create better products. (shrink)

US scholars have ever proposed the doubt of “Who will feed China?” In the past 30 years or so since the reform and opening up in China, China has fed a population accounting for more than 20% of the total population in the world with an area of cultivated land accounting for less than 10% of the total in the world. And the self-sufficiency rate of grain in China still remains above 95%, which is an impressive achievement in Chinese agriculture, (...) and this achievement has been a result of combined action of multiple factors. However, the most critical factor is the successful implementation of agricultural development policies by the Chinese government in the past 30 years or so ever since the reform and opening up in China. (shrink)

Proposal and implementation of “Nanniwan Policy” fully reflects the scientific spirit of being practical and realistic, being innovative and realistic and pragmatic proposed by Zhu De, which has a realistic significance and enlightenment effect on construction of innovative and harmonious society and sustainable development of social economy in the current China. Keywords: Zhu De, Nanniwan policy, scientific spirit, realistic significance During the formidable period of the Anti-Japanese War, in order to resolve the survival issue of soldiers and civilians involved in (...) the war, Zhu De “personally guided development of Nanniwan, promoted the large scale production campaign and made significant contributions to development of production of security of supplies”, (Hu Yaobang, 1986). This is the so-called Nanniwan policy we are talking about. (shrink)

The two-visual-systems hypothesis proposed by Goodale and Milner is a radical one. If it were to be true, then our common sense such as we are acting on what we are perceiving should be completely abandoned. In this paper, I argue that the hypothesis over-generalizes what happens in simple tasks to what happens in complex tasks. By contrast, I demonstrate that what happens in complex tasks is compatible with our common sense. In a word, though what we are acting on (...) may come apart from what we are perceiving in some cases, that is not the whole story. (shrink)

According to the sensitivity account of knowledge, S knows that p only if S's belief in p is sensitive in the sense that S would not believe that p if p were false. It is widely accepted that the sensitivity condition should be relativized to belief-formation methods to avoid putative counterexamples. A remaining issue for the account is how belief-formation methods should be individuated. In this paper, I argue that while a coarse-grained individuation is still susceptible to counterexamples, a fine-grained (...) individuation makes the target belief trivially insensitive. Therefore, there is no principled way of individuating belief-formation methods that helps the sensitivity account to accommodate different cases. (shrink)

Di yi juan. Si wei xue, yuan li lun he zhe xue juan -- Di er juan. Mei xue juan -- Di san juan. Fu hao fen xi he yu yan fen xi juan -- Di si juan. Wen hua xue yu dao de zhe xue juan -- Di wu juan. Shi wen juan.

This article introduces the problem of inexistence to studies in genre and gender, providing a hermeneutic point of reference for literary history and trans theory. It seeks to negotiate the affinities and disaffinities between queer and trans by foregrounding the latter’s struggle for existence against the former’s mobilization of a rhetoric of negative relationality, while at the same time preserving the bonds of intimacy across and beyond the coalition of LGBTQIA+. Such queer intimacy is read in relation to a haptic (...) technology of queer close reading, enabling differentially sexed bodies to imaginatively inhabit each other. I begin by considering how Djuna Barnes’s close, haptic readings of Henry James and Marcel Proust enact a reversal of sex, but I consider how the affective evidence of these trans moments do not amount to trans existence but raise the ethical necessity of holding open the difference between the ephemeral trans experiences within cis existence and the real struggle for trans existence of trans subjects today. Such a divide, however, is simultaneously held against the moments of intimacy that are capable of being produced across cis and trans subjects through such close reading and cross-inhabitation of bodies. To read trans literary history before trans, I thus propose the notion of trans inexistence through an interpretation of Jacques Maritain’s figure of the “angel” and Hegel’s “beautiful soul.” By situating Barnes’s and Jean Genet’s own characterizations of their transfeminine characters in terms of the angel in a post-Romantic, Catholic context, I interpret the trans angel as a figure of inexistence, tied to a minimal transcendence from the terms of history and materiality, including the sexed body. Finally, I consider how Genet’s phenomenology of proprioception draws together the problems of queer intimacy, haptic reading, and trans inexistence. In analyzing how Genet and his characters cross-inhabit each other’s bodies via proprioceptive mimicry, I unfold both the vast potential and the limits of the intimacies constructed across cis male and transfeminine lives and the accompanying role played by the literary mode of romance. (shrink)

In this paper, I explore an intriguing view of definable numbers proposed by a Cambridge mathematician Ernest Hobson, and his solution to the paradoxes of definability. Reflecting on König’s paradox and Richard’s paradox, Hobson argues that an unacceptable consequence of the paradoxes of definability is that there are numbers that are inherently incapable of finite definition. Contrast to other interpreters, Hobson analyses the problem of the paradoxes of definability lies in a dichotomy between finitely definable numbers and not finitely definable (...) numbers. To bypass this predicament, Hobson proposes a language dependent analysis of definable numbers, where the diagonal argument is employed as a means to generate more and more definable numbers. This paper examines Hobson’s work in its historical context, and articulates his argument in detail. It concludes with a remark on Hobson’s analysis of definability and Alan Turing’s analysis of computability. (shrink)

本书包括上编“柏拉图思想的门径”、下编“柏拉图政治哲学管窥”及外编“柏拉图经学史的残篇”等共三编内容。.

Elgar Advanced Introductions are stimulating and thoughtful introductions to major fields in the social sciences, business and law, expertly written by the world's leading scholars. Designed to be accessible yet rigorous, they offer concise and lucid surveys of the substantive and policy issues associated with discrete subject areas. Shanyang Zhao provides a unique examination of this evolving topic with a framework to address the common questions: What is self? How is self formed? and Why does self matter? Drawing a (...) fascinating distinction between self and self-concept, Zhao regards both as part of a larger constellation named the 'self-phenomenon.' He separates social determinants of self from neurocognitive prerequisites of self. Focusing on the social determinants, he reviews how social schemas shape self-concept through three intertwined mechanisms and how social resources affect self-conscious action through social position and social capital. Key Features: A clear distinction between self and self-concept A study of the self as both a social product and a social force A new framework for the sociology of the self, built on the foundation of classic works A close examination of three mechanisms of self-concept formation with specifications of the scope conditions under which each mechanism operates An analysis of the distinctiveness of human normative selves through cross-species comparison This Advanced Introduction will provide essential reading for scholars and researchers in sociology, social psychology, and social policy. (shrink)