Each contributor to this book has used personal experience as the basis from which to frame his individual sociological perspectives. Because they have personalized their work, their accounts are real, and recognizable as having come from 'real' persons, about 'real' experiences. There are no objectively-distanced disembodied third person entities in these accounts. These writers are actual people whose stories will make you laugh, cry, think, and want to know more.

Titin, the largest protein identified to date (over 1 μm long, almost 3 million daltons in mass) is the third most abundant component of the sarcomere. In the mature myofibril, titin molecules span from M line to Z line, forming a third filament system which provides sarcomeric alignment and elastic recoil. In the developing sarcomere, accumulating evidence from studies both in vivo and in vitro implicates titin as part of a morphogenetic scaffolding, upon which critical events in myofibrillogenesis are coordinated (...) in a time‐ and spacedependent manner. (shrink)

This paper explores the important role of critical science, and in particular of post-colonial and decolonial theories, in understanding and shaping the ongoing advances in artificial intelligence. Artificial intelligence is viewed as amongst the technological advances that will reshape modern societies and their relations. While the design and deployment of systems that continually adapt holds the promise of far-reaching positive change, they simultaneously pose significant risks, especially to already vulnerable peoples. Values and power are central to this discussion. Decolonial theories (...) use historical hindsight to explain patterns of power that shape our intellectual, political, economic, and social world. By embedding a decolonial critical approach within its technical practice, AI communities can develop foresight and tactics that can better align research and technology development with established ethical principles, centring vulnerable peoples who continue to bear the brunt of negative impacts of innovation and scientific progress. We highlight problematic applications that are instances of coloniality, and using a decolonial lens, submit three tactics that can form a decolonial field of artificial intelligence: creating a critical technical practice of AI, seeking reverse tutelage and reverse pedagogies, and the renewal of affective and political communities. The years ahead will usher in a wave of new scientific breakthroughs and technologies driven by AI research, making it incumbent upon AI communities to strengthen the social contract through ethical foresight and the multiplicity of intellectual perspectives available to us, ultimately supporting future technologies that enable greater well-being, with the goal of beneficence and justice for all. (shrink)

This paper presents Integrated Information Theory (IIT) 4.0. IIT aims to account for the properties of experience in physical (operational) terms. It identifies the essential properties of experience (axioms), infers the necessary and sufficient properties that its substrate must satisfy (postulates), and expresses them in mathematical terms. In principle, the postulates can be applied to any system of units in a state to determine whether it is conscious, to what degree, and in what way. IIT offers a parsimonious explanation of (...) empirical evidence, makes testable predictions, and permits inferences and extrapolations. IIT 4.0 incorporates several developments of the past ten years, including a more accurate translation of axioms into postulates and mathematical expressions, the introduction of a unique measure of intrinsic information that is consistent with the postulates, and an explicit assessment of causal relations. By fully unfolding a system's irreducible cause-effect power, the distinctions and relations specified by a substrate can account for the quality of experience. (shrink)

© 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare the frequency (...) of the SNPs between different disease cohorts. After adjusting for multiple testing, only PC-risk SNP rs2735839 was significantly and inversely associated with aggressive and high-grade disease in European men. Similar associations with aggressive and high-grade disease were documented in African-American subjects. The G allele of rs2735839 was associated with disease aggressiveness even at low PSA levels in both European and African-American men. Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. Future prospectively designed, case-case GWAS are needed to identify additional SNPs associated with PC aggressiveness. (shrink)

Isaac Newton's Scientific Method examines Newton's argument for universal gravity and his application of it to resolve the problem of deciding between geocentric and heliocentric world systems by measuring masses of the sun and planets. William L. Harper suggests that Newton's inferences from phenomena realize an ideal of empirical success that is richer than prediction. Any theory that can achieve this rich sort of empirical success must not only be able to predict the phenomena it purports to explain, (...) but also have those phenomena accurately measure the parameters which explain them. Harper explores the ways in which Newton's method aims to turn theoretical questions into ones which can be answered empirically by measurement from phenomena, and to establish that propositions inferred from phenomena are provisionally accepted as guides to further research. This methodology, guided by its rich ideal of empirical success, supports a conception of scientific progress that does not require construing it as progress toward Laplace's ideal limit of a final theory of everything, and is not threatened by the classic argument against convergent realism. Newton's method endorses the radical theoretical transformation from his theory to Einstein's. Harper argues that it is strikingly realized in the development and application of testing frameworks for relativistic theories of gravity, and very much at work in cosmology today. (shrink)

William K. Goosens claims to show that my account of epistemic utility runs into serious difficulties when confronted with certain attractive conditions of adequacy for the evaluation of experiments. I show that those conditions of adequacy which are, indeed, acceptable to both of us are satisfied by the procedures for evaluating experiments mandated by combining my theory of epistemic utilities with the approach to evaluating experiments on which Goosens' argument is based. In particular, I demonstrate that my theory does (...) not violate the requirement that an "ideal experiment" be no worse than any alternative experiment. (shrink)

While the evidential problem of evil has been enormously influential within the contemporary philosophical literature—William Rowe’s 1979 formulation in “The Problem of Evil and Some Varieties of Atheism” being the most seminal—no academic research has explored what cognitive mechanisms might underwrite the appearance of pointlessness in target examples of suffering. In this exploratory paper, we show that the perception of pointlessness in the target examples of suffering that underwrite Rowe’s seminal formulation of the problem of evil is contingent on (...) the absence of broader context. In other words, we show that when such suffering is presented alongside broader contextual information, the appearance of pointlessness, on average, significantly diminishes. In §1 we briefly elucidate Rowe’s formulation of the problem of evil and the thought experiment that motivates a key premise. In §2 and §3 respectively, we briefly explain our hypothesis regarding Rowe’s case and our methods for testing these hypotheses. In §4, we elucidate our results, and in §5 we explore some of the philosophical implications of our findings and gesture towards some areas for future research. Finally, in §6, we briefly connect our research to some of the established philosophical literature on suffering and narrative before concluding. (shrink)

Just as it is impossible to understand the American religious landscape without some familiarity with evangelicalism, one cannot grasp the shape of contemporary Christian ethics without knowing the contributions of evangelical Protestants. This newest addition to the Library of Theological Ethics series begins by examining the core dynamic with which all evangelical ethics grapples: belief in an authoritative, inspired, and unchanging biblical text on the one hand, and engagement with a rapidly evolving and increasingly post-Christian culture on the other. It (...) explores the different roles that scholars and popular figures have played in forming evangelicals' understandings of Christian ethics. And it draws together the contributions of both senior and emerging figures in painting a portrait of this diverse, vibrant, and challenging theological and ethical tradition. This book represents the breadth of evangelical ethical voices, demonstrating that evangelical ethics involves nuance and theological insight that far transcend any political agenda. Contributors include David P. Gushee, Carl F. H. Henry, Jennifer McBride, Stephen Charles Mott, William E. Pannell, John Perkins, Soong-Chan Rah, Gabriel Salguero, Francis Schaeffer, Ron Sider, Helene Slessarev-Jamir, Glen H. Stassen, Eldin Villafañe, Allen Verhey, Jim Wallis, Nicholas Wolterstorff, and John Howard Yoder. The Library of Theological Ethics series focuses on what it means to think theologically and ethically. It presents a selection of important, and otherwise unavailable, texts—English-language texts and translations that have fallen out of print, new translations, and collections of significant statements about problems and themes of special importance—in an easily accessible form. This series enables sustained dialogue on new and classic works in the field. (shrink)

Isaac Newton's Scientific Method examines Newton's argument for universal gravity and his application of it to resolve the problem of deciding between geocentric and heliocentric world systems by measuring masses of the sun and planets. William L. Harper suggests that Newton's inferences from phenomena realize an ideal of empirical success that is richer than prediction. Any theory that can achieve this rich sort of empirical success must not only be able to predict the phenomena it purports to explain, (...) but also have those phenomena accurately measure the parameters which explain them. Harper explores the ways in which Newton's method aims to turn theoretical questions into ones which can be answered empirically, by measurement from phenomena, and to establish that propositions inferred from phenomena are provisionally accepted as guides to further research. This methodology, guided by its rich ideal of empirical success, supports a conception of scientific progress that does not require construing it as progress toward Laplace's ideal limit of a final theory of everything, and is not threatened by the classic argument against convergent realism. Newton's method endorses the radical theoretical transformation from his theory to Einstein's. Harper argues that it is strikingly realized in the development and application of testing frameworks for relativistic theories of gravity, and very much at work in cosmology today. (shrink)

Recent advances in philosophy, artificial intelligence, mathematical psychology, and the decision sciences have brought a renewed focus to the role and interpretation of probability in theories of uncertain reasoning. Henry E. Kyburg, Jr. has long resisted the now dominate Bayesian approach to the role of probability in scientific inference and practical decision. The sharp contrasts between the Bayesian approach and Kyburg's program offer a uniquely powerful framework within which to study several issues at the heart of scientific inference, decision, and (...) reasoning under uncertainty. The commissioned essays for this volume take measure of the scope and impact of Kyburg's views on probability and scientific inference, and include several new and important contributions to the field. Contributors: Gert de Cooman, Clark Glymour, William Harper, Isaac Levi, Ron Loui, Enrique Miranda, John Pollock, Teddy Seidenfeld, Choh Man Teng, Mariam Thalos, Gregory Wheeler, Jon Williamson, and Henry E. Kyburg, Jr. (shrink)

Over the past 50 years, Peter Achinstein has earned a reputation in the philosophy of science for careful, thought-provoking, and methodologically significant conceptual analyses. This new book matches that reputation: he begins with a detailed analysis a particular notion, speculation, and the clarified concept serves as the glue to hold together the book's wide-ranging discussions. Achinstein also investigates issues of interest for practicing scientists and the ideas of practicing scientists appear frequently in the book. Indeed, two of the most influential (...) philosophers who discussed speculation were also scientists: John Stuart Mill (who was an economist and psychologist as well as a philosopher) and Isaac Newton. Within a crowded literature on the topic, Achinstein offers a book that is novel, rigorous, and helpful for both philosophers and scientists. (shrink)

This paper examines the cosmological theories of Francis Lodwick (1619-94), the Fellow of the Royal Society, language theorist and close associate of Robert Hooke, concentrating on some unnoticed manuscripts he wrote on this issue. It is demonstrated that Lodwick's account of creation acts as a commentary on the opening chapters of Genesis, influenced in equal measures by the new corpuscular philosophy, and by the heretical, messianic ideas of the Frenchman Isaac La Peyrere, whose Prae-Adamitae (1655) so shocked European scholars. (...) Such a conclusion emphasizes that in the case of Lodwick no clear distinction between biblical criticism and natural philosophy can be maintained, and that the theological ideas he brought to his vortical model of creation were strongly heretical. Such a situation contradicts the proposition insisted upon by early apologists for the Royal Society that the institutionalizing of scientific work would promote orthodox Christianity. (shrink)

Temor y Temblor, de Kierkegaard, escrito bajo el seudónimo de Johannesde silentio, nos ofrece una recreaciónpoética de la historia bíblica de Abraham. Johannes alaba a Abraham como el más eminente caballero de la fe, pero nuestro análisis encuentra que las caracterizaciones que hace de Abraham, como decidido y al mismo tiempo angustiado por el sacrificio de Isaac, entran en conflicto y se mantienen sin resolver. Esto, sumado a la reconocida ignorancia de Johannes en cuestiones de fe, hace que la (...) representación de la fe en Temor y Temblor no sea convincente. Sólo en sus obras tardías Kierkegaard concilia estas dificultades introduciendo una condición "metaestable" de la fe. (shrink)

Most secondary sources about Fear and Trembling do not mention the weaning passages that appear in the "Attunement" chapter. Edward Mooney's book, Knights of Faith and Resignation: Reading Kierkegaard's Fear and Trembling (1991), devotes almost two pages of his commentary to the weaning sentences. While what Mooney suggests was quite helpful in directing my thoughts on this subject, I will present a more sustained discussion of the weaning sentences than Mooney's and argue that the weaning passages are more instrumental in (...) Kierkegaard's presentation of the Abraham and Isaac story than previously imagined. They foreshadow the main theme of Fear and Trembling—the existential leap of faith by the knight of faith. (shrink)

The principal aim of Wetsel's study is to identify the potential interlocutor for whom Pascal intended his Pensées. Wetsel begins by stating his belief that, despite the fragmentary state of the Pensées, Pascal had clearly intended to revise and organize his thoughts into a "finished apology of the Christian religion". Those unfamiliar with the current state of Pascalian studies in North America will be surprised to learn how controversial is such a thesis. In this Derridian era, with its endless fascination (...) with discontinuity and fragmentation, a practically subatomic reading of the Pensées has become de rigueur. Wetsel's book is an unabashed return to the historicocritical tradition. Chapter 1 exposes the principal anti-Christian theses current in midseventeenth-century Paris, centering on the works of philosophes libertins such as La Mothe le Vayer and Gabriel Naud. More radical atheistic works, such as those of Cyrano de Bergerac, are also discussed at length. Wetsel attempts to demonstrate that Pascal is not addressing these libertins érudits, whose arguments against Christianity leave hardly any trace in the Pensées. The chapter concludes with a discussion of the "skeptical religion" popular in seventeenth-century France. Wetsel maintains that this deism with neo-Pelagian elements, essentially the religion of the honnête homme, is the disbelief of those whom Pascal wishes to convert. The following chapter deals with the most important of the unorthodox versions of the Genesis story advanced during the Classical period in France, the works of Isaac de la Peyrère. Wetsel does not propose that Pascal, though familiar with the Pre-Adamite theory of La Peyrère, intended a specific refutation of this author. Rather he believes that a general examination of seventeenth-century heterodoxy provides the fundamental historical context essential for understanding Pascal's defense of orthodoxy. (shrink)

William Whiston was one of the first British converts to Newtonian physics and his 1696 New theory of the earth is the first full-length popularization of the natural philosophy of the Principia. Impressed with his young protégé, Newton paved the way for Whiston to succeed him as Lucasian Professor of Mathematics in 1702. Already a leading Newtonian natural philosopher, Whiston also came to espouse Newton’s heretical antitrinitarianism in the middle of the first decade of the eighteenth century. In all, (...) Whiston enjoyed twenty years of contact with Newton dating from 1694. Although they shared so much ideologically, the two men fell out when Whiston began to proclaim openly the heresy that Newton strove to conceal from the prying eyes of the public. This paper provides a full account of this crisis of publicity by outlining Whiston’s efforts to make both Newton’s natural philosophy and heterodox theology public through popular texts, broadsheets and coffee house lectures. Whiston’s attempts to draw Newton out through published hints and innuendos, combined with his very public religious crusade, rendered the erstwhile disciple a dangerous liability to the great man and helps explain Newton’s eventual break with him, along with his refusal to support Whiston’s nomination to the Royal Society. This study not only traces Whiston’s successes in preaching the gospel of Newton’s physics and theology, but demonstrates the ways in which Whiston, who resolutely refused to accept Newton’s epistemic distinction between ‘open’ and ‘closed’ forms of knowledge, transformed Newton’s grand programme into a singularly exoteric system and drove it into the public sphere.Author Keywords: Isaac Newton; William Whiston; Publicity; New theory; Principia; Royal Society. (shrink)

Not a full treatment of Newton’s scientific method, this book discusses his optical research only in passing (342–43). Its subtitle better indicates its scope: it focuses narrowly on the argument for universal gravitation in Book III of the Principia. The philosophical project is to set out an “ideal of empirical success” realized by the argument. Newton claims his method is to “deduce” propositions “from phenomena.” On Harper’s interpretation Newton’s phenomena are patterns of data, which are used to measure “parameters” by (...) which the theory explains them. An example is Kepler’s Area Rule. Its fit to the data confirms the hypothesis that the force maintaining a body in orbit is directed toward the .. (shrink)