The microbiome of human hair follicles (HFs) has emerged as an important player in different HF and skin pathologies, yet awaits in‐depth exploration. This raises questions regarding the tightly linked interactions between host environment, nutrient dependency of host‐associated microbes, microbial metabolism, microbe‐microbe interactions and host immunity. The use of simple model systems facilitates addressing generally important questions and testing overarching, therapeutically relevant principles that likely transcend obvious interspecies differences. Here, we evaluate the potential of the freshwater polyp Hydra, to dissect (...) fundamental principles of microbiome regulation by the host, that is the human HF. In particular, we focus on therapeutically targetable host‐microbiome interactions, such as nutrient dependency, microbial interactions and host defence. Offering a new lens into the study of HF – microbiota interactions, we argue that general principles of how Hydra manages its microbiota can inform the development of novel, microbiome‐targeting therapeutic interventions in human skin disease. (shrink)

Preface ix 1 Meaning and the Means to an Understanding of Ends 2 Why Is an Eye? 21 3 Adaptationism and Engineering 39 4 On Five "-Isms" 67 5 Function, Selection, and Explanation 87 6 Deflating Function 119 7 Artifacts and Organisms 139 References 167 Index 177.

This book defends and outlines the key issues surrounding the philosophy of content as demonstrated in Wittgenstein's Philosophical Investigations. The text shows how Wittgenstein's critical arguments concerning mind and meaning are destructive of much recent work in the philosophy of thought and language, including the representationalist orthodoxy. These issues are related to the work of Davidson, Rorty and McDowell among others.

"Postmodernism" has become the buzzword of contemporary society. Yet it remains baffling in its variety of definitions, contexts and associations. Beginning Postmodernism aims to offer clear, accessible and step-by-step introductions to postmodernism across a wide range of subjects. It encourages readers to explore how the debates about postmodernism have emerged from basic philosophical and cultural ideas. With its emphasis firmly on "postmodernism in practice," the book contains exercises and questions designed to help readers understand and reflect upon a variety of (...) positions in the following areas of contemporary culture: philosophy and cultural theory; architecture and concepts of space; visual art; sculpture and the design arts; popular culture and music; film, video and television culture; and the social sciences. (shrink)

Elements of Mind provides a unique introduction to the main problems and debates in contemporary philosophy of mind. Author Tim Crane opposes those currently popular conceptions of the mind that divide mental phenomena into two very different kinds (the intentional and the qualitative) and proposes instead a challenging and unified theory of all the phenomena of mind. In light of this theory, Crane engages students with the central problems of the philosophy of mind--the mind-body problem, the problem of intentionality (or (...) mental representation), the problem of consciousness, and the problem of perception--and attempts to find solutions to these problems. A fresh and engaging exploration of the main issues in the philosophy of mind, Elements of Mind is easily accessible to students with no background in the subject. (shrink)

Science is our best way of finding out about the natural world, and philosophers who write about that world ought to be sensitive to the claims of our best science. There are obstacles, however, to outsiders using science well. We think philosophers are prone to misuse science: to give undue weight to results that are untested; to highlight favorable and ignore unfavorable data; to give illegitimate weight to the authority of science; to leap from scientific premises to philosophical conclusions without (...) spelling out their relevance; to treat mere resonance between a scientific theory and a philosophical view as empirical evidence for the philosophical view. This article identifies and illustrates some of the ways in which philosophers misuse science, explains why these pitfalls are easy to fall into, and concludes with suggestions for avoiding them. (shrink)

Abstract The only biologically respectable notion of human nature is an extremely permissive one that names the reliable dispositions of the human species as a whole. This conception offers no ethical guidance in debates over enhancement, and indeed it has the result that alterations to human nature have been commonplace in the history of our species. Aristotelian conceptions of species natures, which are currently fashionable in meta-ethics and applied ethics, have no basis in biological fact. Moreover, because our folk psychology (...) finds this misleading Aristotelian conception highly tempting, we are in fact better off if we refrain from mentioning human nature altogether in debates over enhancement. Content Type Journal Article Category Special Issue Pages 1-16 DOI 10.1007/s13347-012-0063-x Authors Tim Lewens, Department of History and Philosophy of Science, University of Cambridge, Free School Lane, Cambridge, CB2 3RH UK Journal Philosophy & Technology Online ISSN 2210-5441 Print ISSN 2210-5433. (shrink)

Organizational ethics—defined as the alignment of an institution’s practices with its mission, vision, and values—is a growing field in health care not well characterized in empirical literature. To capture the scope and context of organizational ethics work in United States healthcare institutions, we conducted a nationwide convenience survey of ethicists regarding the scope of organizational ethics work, common challenges faced, and the organizational context in which this work is done. In this article, we report substantial variability in the structure of (...) organizational ethics programs and the settings in which it is conducted. Notable findings included disagreement about the activities that comprise organizational ethics and a lack of common metrics used to assess organizational ethics activities. A frequently cited barrier to full engagement in these activities was poor institution-wide understanding about the role and function of organizational ethics resources. These data suggest a tension in the trajectory of organizational ethics’ professionalization: while some variability is appropriate to the field’s relative youth, inadequate attention to definitions of organizational ethics practice and metrics for success can impede discussions about appropriate institutional support, leadership context, and training for practitioners. (shrink)

Elliott Sober and his defenders think of selection, drift, mutation, and migration as distinct evolutionary forces. This paper exposes an ambiguity in Sober's account of the force of selection: sometimes he appears to equate the force of selection with variation in fitness, sometimes with ‘selection for properties’. Sober's own account of fitness as a property analogous to life-expectancy shows how the two conceptions come apart. Cases where there is selection against variance in offspring number also show that selection and drift (...) cannot be distinguished in the way Sober hopes for. These issues have significance beyond the parochial matter of the coherence of Sober's system. There is no good principled answer to the question of which features of a population should count among the contributors to fitness. This means there is no non-arbitrary account of the nature of selection. (shrink)

How can we determine an acceptable level of risk? Should these decisions be made by experts, or by the people they affect? How should safety and security be balanced against other goods, such as liberty? This is the first collection to examine the philosophical dimensions of these pressing practical problems. Leading scholars exploring the full range of philosophical implications of risk, including: risk and ethics risk and rationality risk and scientific expertise risk and lay knowledge the objectivity of risk assessment (...) risk and the precautionary principle risk and terror. With contributions from Carl F. Cranor, Sven Ove Hansson, Martin Kusch, Tim Lewens, D.H. Mellor, Adam Morton, Stephen Perry, Martin Peterson, Alan Ryan, Per Sandin, Cass R. Sunstein and Jonathan Wolff; this collection is essential reading, not only for philosophers and researchers in legal, economic and environmental studies, but for those seeking to gain a better understanding of the decisions we must make as concerned citizens. (shrink)

It is widely agreed that perceptual experience is a form of intentionality, i.e., that it has representational content. Many philosophers take this to mean that like belief, experience has propositional content, that it can be true or false. I accept that perceptual experience has intentionality; but I dispute the claim that it has propositional content. This claim does not follow from the fact that experience is intentional, nor does it follow from the fact that experiences are accurate or inaccurate. I (...) end by considering the relationship between this question and the question of whether experience has non‐conceptual content. (shrink)

Synthetic biology is often described as a project that applies rational design methods to the organic world. Although humans have influenced organic lineages in many ways, it is nonetheless reasonable to place synthetic biology towards one end of a continuum between purely ‘blind’ processes of organic modification at one extreme, and wholly rational, design-led processes at the other. An example from evolutionary electronics illustrates some of the constraints imposed by the rational design methodology itself. These constraints reinforce the limitations of (...) the synthetic biology ideal, limitations that are often freely acknowledged by synthetic biology’s own practitioners. The synthetic biology methodology reflects a series of constraints imposed on finite human designers who wish, as far as is practicable, to communicate with each other and to intervene in nature in reasonably targeted and well-understood ways. This is better understood as indicative of an underlying awareness of human limitations, rather than as expressive of an objectionable impulse to mastery over nature. (shrink)

The four tenets of the Strong Program are compatible with a scientific realism founded on an externalist epistemology. Such an epistemology allows that appropriate norms of rationality may differ from time to time, and from community to community, and thereby enables the realist to embrace strong forms of the ‘symmetry principle’. It also suggests a fruitful collaborative research program in externalist social epistemology. Some of what the Edinburgh School says about truth can also be accepted. But the realist should reject (...) the School's argument for the claim that there is no distinction between being rational and being locally accepted as rational, which seems to rest on a kind of epistemological internalism. Introducing the Strong Program Realism and the four tenets A stronger reading of symmetry Conflict and cooperation A note on discovery and justification Relativism and realism Truth Points of contention: the restriction of explanatory contrasts Points of contention: standards of rationality. (shrink)

Epistemological disjunctivism, as defended by, for example, McDowell, Neta and Pritchard, is the view that epistemic justification can be – and in paradigmatic cases of perceptual knowledge actually is – both factive and reflectively accessible. One major problem for this view is the access problem: apparently, epistemological disjunctivism entails that ordinary external world propositions can be known by reflection alone. According to epistemological disjunctivism, seeing that the sun is shining is reflectively accessible and seeing that the sun is shining entails (...) that it is. Assuming closure of reflective knowledge under known entailment it is also reflectively knowable that the sun is shining. Drawing on joint work with Neta, Pritchard replies that disjunctivism is not committed to this absurdity, but only to the possibility of reflective access to empirical reasons. In this article I offer an interpretation of this reply, but also an objection to it: my interpretation is based on applying the source/content distinction to epistemic reasons. My objection is based on arguing that the access problem is a problem for any version of access internalism. Although Pritchard's reply solves the general access problem, it does not solve the access problem that is generated by the specific commitments of epistemological disjunctivism. Due to the transparency of self-knowledge of propositional perception, epistemological disjunctivism cannot meet a central requirement for applying the source/content distinction. (shrink)

Pt. I. Wittgenstein. Introduction -- Short biography -- Pt. II. Philosophy. Wittgenstein and philosophy -- Wittgenstein's later philosophy -- Pt. III. Theology. Wittgenstein and theology -- Wittgenstein and the theologian -- Wittgenstein in theological practice -- Explanations, doubt and redemption.

Deze tekst vertrekt vanuit een van de meest invloedrijke denkers in de metafysica, namelijk Aristoteles. We lezen hem via de interpretatie van Giorgio Agamben in het artikel On potentiality. 4 Agamben werpt in die tekst een nieuw licht op het onderscheid tussen potentialiteit en act. De Westerse metafysica heeft vaak de act geprivilegieerd boven de potentialiteit. Enkel actuele entiteiten zouden bestaan, terwijl mogelijkheden behoren tot het domein van de verbeelding. Aristoteles ondermijnt deze stelling volgens Agamben. De mens als redelijk dier (...) is een potentieel wezen. De verwerkelijking van zijn essentie is het cultiveren van de rede als potentialiteit. In de mens zijn act en potentialiteit één. Daarom moeten wij begrijpen in welke zin potentialiteiten bestaan en hoe zij zich verhouden tot de act. Het antwoord vinden wij in de verwerkelijking van impotentialiteit, of het vermogen om dingen niet te doen. De mens kan niet enkel x doen, maar ook actief x niet-doen. Bijvoorbeeld in de vasten kan men van niet-eten een project maken. Agambens studie van impotentialiteit verduidelijkt daarmee wat de termen ‘act’ en ‘potentialiteit’ precies betekenen. Agamben stelt voor om elke actualisering te begrijpen als de opschorting van een impotentialiteit. De vaster die begint te eten, schort zijn project tot niet-eten op. Los van deze of gene actualisering is de wereld eerst de verzamelnaam voor alle mogelijke actualiseringen en die mogelijkheden zijn nooit uitgeput in eender welke actualisering van de wereld. De mens is dan het wezen dat, dankzij zijn impotentialiteit, inziet dat de wereld steeds meer is dan enkel wat het geval is. (shrink)

Many Americans don't hold journalists in very high regard these days, and sports journalists are often viewed in the least favorable light. The general public does not perceive any visible, unified, and concerted effort among sportswriters to practice their craft in a consistently ethical manner. Efforts to upgrade the craft include the Associated Press Sports Editors ethical guidelines, which cover freebies, moonlighting, community involvement by sports journalists, and commercial sponsors of sporting events. This study examines the APSE code and suggests (...) additional, more specific, and enforceable guidelines in ten areas: freebies, moonlighting, newsgathering methods, news sources, direct quotes, privacy, gambling, special interests, self?interests, and involvements. Sports journalists should be as ethically accountable as any other journalists, the author concludes. (shrink)

My strategy is to assume a "market libertarian" ideology for the purposes of this paper and then argue that employment offers directed toward people in desperate circumstances are predatory immoral offers. I develop comparisons between predatory behaviour that is widely held to be immoral (cases where people in power prey on the desperate, i.e., people who are desperately hungry, ignorant, secretive, etc.,) and the predatory behaviour of corporate agents who prey on desperate people for cheap labour. What all of these (...) cases have in common is that the predator takes advantage of the fact that the prey is not in a position to make a meaningful choice. When this argument by analogy is put in the context of the libertarian insistence that voluntary exchanges are at the foundation of everyone's freedom, it represents a devastating critique of neo-liberal consistency. (shrink)

Volume 24, Issue 6, September 2019, Page 657-661.

Volume 25, Issue 2, February - March 2020, Page 203-208.

Social epistemology has paid little attention to oral historiography as a source of expert insight into the credibility of testimony. One extant suggestion, however, is that oral historians treat testimony with a default trust reflecting a standing warrant for accepting testimony. The view that there is such a standing warrant is sometimes known as the Acceptance Principle for Testimony. I argue that the practices of oral historians do not count in support of APT, all in all. Experts have commonly described (...) oral traditions as oriented towards political, cultural and entertainment ends, and not only—or not even—towards an accurate depiction of past events. Even when accuracy is the emphasis, many historians of oral tradition do not trust such testimony as APT would suggest; the importance of gathering supporting evidence is a consistent emphasis. Yet oral historiography, both of traditions and more generally, does hold out lessons for the epistemology of testimony, implicating a wider range of social.. (shrink)

This paper begins by exploring a subspecies of assertion. Under some circumstances an utterance intuitively counts as an assertion, even though it is Cynical: that is, it is insincere, and made without the reasonable expectation of even appearing sincere to its audience. The paper explores the contextual and cognitive workings of Cynical assertion – directly, in part, but also by comparison with superficially similar but non-assertoric utterances, namely, those made under duress. Finally, the paper examines the broader relevance of Cynical (...) assertion, by considering two philosophical applications of the notion: first, in support of Michael Dummett’s conventionalist account of assertion; and second, in illuminating an aspect of Moore’s paradox. (shrink)

Alex Mesoudi’s book shows cultural evolution to be a mature field, which has already illuminated many instances of cultural change. Mesoudi’s presentation of the discipline nonetheless invites three objections. First, the culture concept it makes use of is not clearly defined; second, Mesoudi’s historical argument which looks back to the modern synthesis in order to predict an analogous synthesis in the social sciences is flawed; third, Mesoudi’s understanding of the positions held by leading figures within social science is shaky.

The varying demands of justice are often thought to depend on a distinction between natural and social inequalities, but making this distinction has been little discussed, and it has been dismissed by philosophers of biology. It cannot be established by a simple causal criterion, nor by use of the analysis of variance, nor by distinguishing the innate from the acquired. Whether an inequality can be socially controlled provides the most plausible criterion, so 'natural' and 'social' are misleading labels for types (...) of inequality. The analysis of these depends, besides, on how fine-grained the descriptions are; so it is implausible to think that the natural/social distinction, when drawn in terms of social control, is relevant to theories of justice. (shrink)