Pericytes, like vascular smooth muscle cells, are perivascular cells closely associated with blood vessels throughout the body. Pericytes are necessary for vascular development and homeostasis, with particularly critical roles in the brain, where they are involved in regulating cerebral blood flow and establishing the blood-brain barrier. A role for pericytes during neurovascular disease pathogenesis is less clear—while some studies associate decreased pericyte coverage with select neurovascular diseases, others suggest increased pericyte infiltration in response to hypoxia or traumatic brain injury. Here, (...) we used an endothelial loss-of-function Recombination signal binding protein for immunoglobulin kappa J region (Rbpj)/Notch mediated mouse model of brain arteriovenous malformation (AVM) to investigate effects on pericytes during neurovascular disease pathogenesis. We tested the hypothesis that pericyte expansion, via morphological changes, and Platelet-derived growth factor B/Platelet-derived growth factor receptor β (Pdgf-B/Pdgfrβ)-dependent endothelial cell-pericyte communication are affected, during the pathogenesis of Rbpj mediated brain AVM in mice. Our data show that pericyte coverage of vascular endothelium expanded pathologically, to maintain coverage of vascular abnormalities in brain and retina, following endothelial deletion of Rbpj. In Rbpj-mutant brain, pericyte expansion was likely attributed to cytoplasmic process extension and not to increased pericyte proliferation. Despite expanding overall area of vessel coverage, pericytes from Rbpj-mutant brains showed decreased expression of Pdgfrβ, Neural (N)-cadherin, and cluster of differentiation (CD)146, as compared to controls, which likely affected Pdgf-B/Pdgfrβ-dependent communication and appositional associations between endothelial cells and pericytes in Rbpj-mutant brain microvessels. By contrast, and perhaps by compensatory mechanism, endothelial cells showed increased expression of N-cadherin. Our data identify cellular and molecular effects on brain pericytes, following endothelial deletion of Rbpj, and suggest pericytes as potential therapeutic targets for Rbpj/Notch related brain AVM. (shrink)

The study of human diversity in the first half of the 19th century has traditionally been categorized as a type of armchair-based natural history. If we are to take seriously this characterization of the discipline it requires further unpacking. Armchair anthropology was not a passive pursuit, with minimal analytical reflection that simply synthesized the materials of other writers. Nor was it detached from the activities of informants who were collecting and recording data in the field. Practitioners in the 19th century (...) were highly attuned to the problems associated with their research techniques and continually sought to transform their methodologies. The history of British anthropological research is one of gradual change and the adoption of new observational techniques into its methodologies. This article looks at the history of 19th-century British anthropology and examines in detail the observational practices of its researchers. In doing so it aims to answer the question: What is armchair anthropology? (shrink)

SummaryDuring the 1860s the sciences relating to human diversity were undergoing significant intellectual and methodological changes. The older generation of practitioners including James Cowles Prichard, Thomas Hodgkin and John Crawfurd were slowly passing away. Recognising that there was an opportunity to take a leading role in reforming the study of human variation, two competing intellectual camps vied for control of the nascent discipline; anthropologists led by James Hunt, and ethnologists led by Thomas Huxley. Taking their observational practices and vocational strategies (...) as its starting point, this paper seeks to expand our understanding of the debates surrounding British race studies during the 1860s. In doing so, this paper takes seriously Hunt and Huxley's self-descriptions as scientific reformers. Both of these figures promoted strategies for transforming the sciences relating to human diversity. Each believed they were strengthening anthropology and ethnology's best aspects and dispensing with their weakest. Moreover, their training in natural history, anatomy and physiology can be seen to have influenced their observational practices when it came to identifying and classifying human varieties. (shrink)

This paper examines the complex observational techniques of British anthropologists during the nineteenth century. In particular, using Galton’s initial work with anthropometric and composite photography in the late 1870s as a case study, it argues that nineteenth-century anthropological armchair studies were extremely sophisticated and that researchers were highly attuned to the problems associated with their methodologies. These nineteenth-century practitioners were not simply anthologising the materials of others; rather they were developing specialised methods for producing their own evidence and drawing conclusions. (...) Moreover, Galton’s use of photographic processes is instructive because it highlights one of the ways in which researchers interested in human diversity attempted to add further scientific credibility to their arguments by utilising the most cutting-edge technologies available during the period. (shrink)

Study on Pramnānabhūta, Buddhist logic of authoritative.

This paper explores the process from museumization to decolonization through an examination of a Haida eagle mask currently on display in the Exploring Medicine gallery at the Science Museum in London. While elements of this discussion are well developed in some disciplines, such as Indigenous studies, anthropology and museum and heritage studies, this paper approaches the topic through the history of science, where decolonization and global perspectives are still gaining momentum. The aim therefore is to offer some opening perspectives and (...) methods on how historians of science can use the ideas and approaches relating to decolonization in other fields, and apply them constructively to the history of science, particularly in museum settings. Decolonization is a complicated process and the focus of this paper is squarely on the preliminary steps of its implementation. To understand this process fully, the paper will recontextualize the Indigenous history of the Haida eagle mask at the Science Museum through a careful reconstruction of its provenance record. Through this process it will expose the politics of erasure and hidden voices in museum collections. (shrink)

How to engage farmers that have limited formal education is at the foundation of environmentally-sound and equitable agricultural development. Yet there are few examples of curricula that support the co-development of knowledge with farmers. While transdisciplinary and participatory techniques are considered key components of agroecology, how to do so is rarely specified and few materials are available, especially those relevant to smallholder farmers with limited formal education in Sub-Saharan Africa. The few training materials that exist provide appropriate methods, such as (...) compost making, but do not explain relationships and synergies between nutrition, social inequalities, climate change and agroecology. Some food sovereignty and agroecology courses aim at popular political education for those with more formal education. Here we describe the process of development of an innovative curriculum, which integrates agroecology, nutrition, climate change, gender and other dimensions of social equity across 2 weeks of training explicitly for smallholders in southern Africa with limited formal education. The curriculum is highly participatory; we use concepts in popular education, transformative and experiential-based learning, and theatre. It is also integrative; we link agroecology with climate change, human and soil nutrition, gender, and related components of social equity. Developed in partnership with Malawian farmers, community development experts and academics from five countries, the curriculum was piloted with 520 smallholder farming households in Malawi and Tanzania, and evaluated using qualitative techniques. Clashes of language, cultural norms, and terminology were as great of a challenge as agreeing on and conveying technical information, to weave into a coherent whole. However, farmers who participated in the curriculum training demonstrated high interest, comprehension of material and interest in immediate application to their lives. (shrink)

According to usage-based theories, children initially acquire surface-level constructions and then abstract representations. If so, bilingual children might show lags relative to monolingual children early in acquisition, but not later on, once they rely on abstract representations. We tested this prediction with comprehension of passives in 3- to 6-year-old children: French–English bilinguals and English monolinguals. As predicted, younger bilingual children tended to be less accurate than monolingual children. In contrast, the older bilingual children scored equivalently to monolinguals, despite less exposure (...) to English. When the children made errors, the bilingual children were more likely to interpret the subject as the agent of the action than the monolingual children. These results are consistent with the argument that children develop increasingly abstract representations of linguistic constructions with usage. They further suggest that bilingual children might catch up with monolingual through use of selective attention and/or a semantic bias. (shrink)

BackgroundSex and gender differences are often overlooked in research design, study implementation and scientific reporting, as well as in general science communication. This oversight limits the generalizability of research findings and their applicability to clinical practice, in particular for women but also for men. This article describes the rationale for an international set of guidelines to encourage a more systematic approach to the reporting of sex and gender in research across disciplines.MethodsA panel of 13 experts representing nine countries developed the (...) guidelines through a series of teleconferences, conference presentations and a 2-day workshop. An internet survey of 716 journal editors, scientists and other members of the international publishing community was conducted as well as a literature search on sex and gender policies in scientific publishing.ResultsThe Sex and Gender Equity in Research (SAGER) guidelines are a comprehensive procedure for reporting of sex and gender information in study design, data analyses, results and interpretation of findings.ConclusionsThe SAGER guidelines are designed primarily to guide authors in preparing their manuscripts, but they are also useful for editors, as gatekeepers of science, to integrate assessment of sex and gender into all manuscripts as an integral part of the editorial process. (shrink)

How to engage farmers that have limited formal education is at the foundation of environmentally-sound and equitable agricultural development. Yet there are few examples of curricula that support the co-development of knowledge with farmers. While transdisciplinary and participatory techniques are considered key components of agroecology, how to do so is rarely specified and few materials are available, especially those relevant to smallholder farmers with limited formal education in Sub-Saharan Africa. The few training materials that exist provide appropriate methods, such as (...) compost making, but do not explain relationships and synergies between nutrition, social inequalities, climate change and agroecology. Some food sovereignty and agroecology courses aim at popular political education for those with more formal education. Here we describe the process of development of an innovative curriculum, which integrates agroecology, nutrition, climate change, gender and other dimensions of social equity across 2 weeks of training explicitly for smallholders in southern Africa with limited formal education. The curriculum is highly participatory; we use concepts in popular education, transformative and experiential-based learning, and theatre. It is also integrative; we link agroecology with climate change, human and soil nutrition, gender, and related components of social equity. Developed in partnership with Malawian farmers, community development experts and academics from five countries, the curriculum was piloted with 520 smallholder farming households in Malawi and Tanzania, and evaluated using qualitative techniques. Clashes of language, cultural norms, and terminology were as great of a challenge as agreeing on and conveying technical information, to weave into a coherent whole. However, farmers who participated in the curriculum training demonstrated high interest, comprehension of material and interest in immediate application to their lives. (shrink)

Galvao-Pedro_Sera-o-contratualismo-reconciliavel-com-o-consequencialismo.

Le possible s'y revele a l'etat pur et c'est pourquoi le titre en devient un verbe actif; Le Sera.

The Sera Jey Monastery, reestablished near Mysore, India, houses 5,000 Buddhist monks living in exile -- including survivors of the destruction of the Tibetan monastery in 1959. Sheila Rock's moving portraits are a celebration of the everyday simplicity and subtle beauty of the ascetic life. More than a hundred duotone photographs document the compassionate expressions, emotional openness, and aura of serenity inspired by lives of renunciation and seclusion. A percentage of the royalties from this book go to the (...) class='Hi'>Sera Jhe Health Care Committee in aid of various humanitarian projects. (shrink)

Dans ce second volume de la suite Le Chemin du Vieux-Moulin, l'accent est mis sur le passage lui-meme, sur ce qui fait que rien se subsiste jamais comme avant sans qu'on puisse prevoir l'apres. Le possible s'y revele a l'etat pur et c'est pourquoi le titre en devient un verbe actif; Le Sera. Comme on s'en est rendu compte avec Justice et terreur, Leibniz devient un a propos dont l'historien de la philosophie n'a rien perdu du souvenir, mais dont (...) le philosophe se demande a quoi conduisent ces neologismes ou ces expressions qui saccadent l'oeuvre d'autant d'aphorismes ombres. Mais quel jet de lumiere porter sur les termes en hapax comme existiturientia que Leibniz lance, comme tant d'autre, a quelque detour de son oeuvre, comme si c'etait dans cette direction jusque-la innommee qu'il en faille suivre l'inspiration? Ainsi le futurible, l'attente, l'emanable, le vivant, plus comme a vivre que comme vecu, sont-ils projetes au premier plan comme la possibilite meme de ces etats contingents qui s'envuivent de ce qu'il faudra bien appeler emanantion. (shrink)

Natureza e Cultura: será que o humano nos deixará de ser tão estranho?

Pour comprendre le verset énigmatique de Mc 9,49, «Chacun sera salé au feu», l’auteur adopte, parmi les variantes du texte, la «lectio difficilior»: celle qui ne confond pas l’action du sel avec celle du feu ou réciproquement. Il cherche ensuite des indices originaux de compréhension chez quelques commentateurs faisant autorité. Enfin, il analyse les différents usages du sel auxquels les textes évangéliques font implicitement référence. Il les replace dans le contexte de l’activité artisanale de l’homme Jésus, ainsi que dans (...) la perspective de sa prédication: annonce du Royaume, de sa mort et de sa résurrection. Tout cela permet à l’auteur de retrouver, sous l’expression du «sel au feu», une métaphore, voire une parabole: celle du potier qui asperge de sel dans le feu de son four ses «poteries de terre», afin de les rendre non seulement imputrescibles, mais brillantes et belles. Ainsi agit Dieu Trinité envers les hommes en son oeuvre de résurrection libératrice de tout mal. De cette destinée, découle une éthique pour le présent: chercher la paix. (shrink)

Having suggested that a salient feature of philosophical naturalism is to deny that there are non‐natural norms, I make a distinction between a moderate naturalism, which admits the existence of natural norms , and a radical naturalism which denies it . On the assumption that intentional facts are irreducibly normative, their existence would thus seem to raise a problem for moderate epistemological naturalism. I argue that no non‐trivial naturalistic explanation of conceptual intentionality is to be possible unless it is denied (...) that norms of rationality are constitutive of intentional content. It follows that the only form of intentional naturalism that is not obviously untenable has to be radical. Other aspects of Quine's doctrine suggest that the introduction of epistemic norms into our “system of the world” is either dubiously coherent, or “merely programmatic”. (shrink)

Having suggested that a salient feature of philosophical naturalism is to deny that there are non‐natural norms, I make a distinction between a moderate naturalism, which admits the existence of natural norms, and a radical naturalism which denies it. On the assumption that intentional facts are irreducibly normative, their existence would thus seem to raise a problem for moderate epistemological naturalism. I argue that no non‐trivial naturalistic explanation of conceptual intentionality is to be possible unless it is denied that norms (...) of rationality are constitutive of intentional content. It follows that the only form of intentional naturalism that is not obviously untenable has to be radical. Other aspects of Quine's doctrine suggest that the introduction of epistemic norms into our “system of the world” is either dubiously coherent, or “merely programmatic”. (shrink)

O naturalismo metafísico é a perspetiva de que não há uma pessoa como Deus, nem algo semelhante a Deus. Alvin Plantinga tem argumentado que esta perspetiva é auto-refutante e, por isso, irracional. Isto porque se o naturalismo metafísico fosse verdadeiro (em conjunção com a teoria da evolução), então teríamos fortes razões para duvidar da fiabilidade das nossas faculdades cognitivas e, por conseguinte, teríamos fortes razões para duvidar da verdade de qualquer das nossas crenças, inclusive do naturalismo metafísico. O meu objetivo (...) neste artigo é examinar criticamente este argumento de Plantinga contra o naturalismo metafísico e analisar se é capaz de lidar com algumas objeções. (shrink)

In the last decades aquaculture is receiving great attention because of its health-related benefits.The objective of this work was to verify the socioeconomic profile and identify the fish consumption of individuals residing in the municipality of Seara, located in the west of Santa Catarina state, as well as the quantity they consume and the reasons that would make them consume more fish. The research has a quali-quantitative, descriptive, and transversal nature. 376 individuals were interviewed, with a questionnaire consisting of 30 (...) objective and subjective questions. This research project was submitted to and approved by the Ethics and Research Committee of the Universidade Federal da Fronteira Sul (UFFS). The results showed that as the level of education and income increases, so does the amount of fish consumed by the interviewees. It was noticed that a large part of the population consumes fish, however the amount consumed is below the recommended. Among the reasons that would make the population increase their fish intake are more accessible prices and incentives. (shrink)

El presente artículo tiene como objetivo estudiar dos problemas fundamentales del transhumanismo: la edición genética (específicamente el caso de CRISPR/Cas9) y el _mind uploading _a la luz del concepto de tecnología gótica. La apropiación de la categoría de lo gótico pretende vislumbrar las contradicciones de la racionalidad científica y tecnológica gracias a algunas de sus premisas filosóficas (hibridación, fantasmagoría, entre otras). Al mismo tiempo y derivado de estos análisis, se hará un bosquejo de los problemas relacionados con una futura sociedad (...) posthumana en los aspectos éticos, militares, políticos, sociales y filosóficos. Al reflexionar sobre la sociedad posthumana, también se destacará el lugar del sujeto y su posible extinción por medio de estas tecnologías. _Palabras clave: _Transhumanimo, Mind Uploading, CRISPR, filosofía de la tecnología, tecnología gótica. (shrink)