In the mouse, at least 16 genes regulate vesicle trafficking to specialized lysosome‐related organelles, including platelet dense granules and melanosomes. Fourteen of these genes have been identified by positional cloning. All 16 mouse mutants are models for the genetically heterogeneous human disease, Hermansky–Pudlak Syndrome (HPS). Five HPS genes encode known vesicle trafficking proteins. Nine genes are novel, are found only in higher eukaryotes and encode members of three protein complexes termed BLOCs (Biogenesis of Lysosome‐related Organelles Complexes). Mutations in murine HPS (...) genes, which encode protein co‐members of BLOCs, produce essentially identical phenotypes. In addition to their well‐known effects on pigmentation, platelet function and lysosome secretion, HPS genes control a wide range of physiological processes including immune recognition, neuronal functions and lung surfactant trafficking. Studies of the molecular functions of HPS proteins will reveal important details of vesicle trafficking and may lead to therapies for HPS. BioEssays 26:616–628, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

Purpose The COVID-19 pandemic broke out at the end of 2019, and throughout 2020 there were intensive international efforts to find a vaccine for the disease, which had already led to the deaths of some five million people. In December 2020, several pharmaceutical companies announced that they had succeeded in producing an effective vaccine, and after approval by the various regulatory bodies, countries started to vaccinate their citizens. With the start of the global campaign to vaccinate the world’s population against (...) COVID-19, debates over the prioritization of different sections of the population began around the world, but the prison population has generally been absent from these discussions. Approach and Findings This article presents the approach of Jewish ethics regarding this issue, that is, that there is a religious and a moral obligation to heal the other and to take care of his or her medical well-being and that this holds true even for a prisoner who has committed a serious crime. Hence, prisoners should be vaccinated according to the same priorities that govern the administration of the vaccine among the general public. Originality The originality of the article is in a comprehensive and comparative reference between general ethics and Jewish ethics on a subject that has not yet received the proper attention. (shrink)

This volume consists of a collection of essays that explores the songs of Rabindranath Tagore, also known as Rabindrasangeet as independent poetic verses. It is an intellectual reading of his songs that are collected in the Gitabitan, which is a collection of all of his 2232 songs.

Sri Aurobindo dedicated his life to the transformation of humanity. His journey saw him traverse many paths, including that of poet, journalist, jailed revolutionary, philosopher, and radical mystic. Essays, translations, literary criticism, political articles, philosophical treatises, poetry, epics, plays and short stories-his writings encompass the depth and range of his extraordinary life. The modern sage commented on spiritual texts such as the Vedas, the Upanishads and the Bhagwad Gita, authored an epic poem, Savitri, presented his integral vision in The Life (...) Divine, wrote on contemporary issues, all the while writing thousands of letters to guide his disciples, and even documenting his inner life in meticulous detail. The relevance of Sri Aurobindo's message has never been more urgent and compelling, yet, his Complete Works, thirty-six volumes in all, can be a daunting prospect even for those acquainted with his philosophy and practice. Reading Sri Aurobindo introduces each of these volumes through the perspectives of twenty-one contributors. The result is a book packed with insights inviting us to explore Sri Aurobindo's deep wisdom and vision for resolving the fundamental issues facing individuals, societies, and nations today. (shrink)

This study compares the codes of media ethics adopted by the PCCPress Complaints Commission, the IFJInternational Federation of Journalists and the SPJSociety of Professional Journalists based on the claim that it is the public's right to know, and examines the origins of this concept. A new approach is presented here which falls between the liberal-democratic approach on the one hand and on the other, the extreme ultra-Orthodox approach that claims that it is the public's duty not to know. This new (...) approach which indicates that it is the public's duty to know has evolved from the analysis of Jewish texts from Biblical times and from the study of events in Jewish community life throughout the world. This novel approach is likely to effect a change in the contents of broadcasts and in the boundaries of media ethics. (shrink)

Philosophy, Arab; philosophy, European; knowledge, theory of.

As students progress towards their PhD degrees, they will become more independent and practitioner-like; for those moving into academia, it is often assumed the programs of their PhD mentors will serve as prototypes for their own successful research programs. However, the author's research program as an Assistant Professor led him in directions never considered as a graduate student. The author had to make significant decisions in choosing a primary audience, finding an overarching theme, defining the individual problems, and developing these (...) problems into researchable projects. Infrastructure-related issues associated with the author's research program were also considered. The details of his journey from the end of his doctoral degree to his current position as an Assistant Professor are described in this article. (shrink)

The purpose of the paper is to refute the fregean assumption that declarative sentences refer to truth-Values. A consequence of the assumption is that the truth-Value of a declarative sentence containing another as part remains unchanged when the part is replaced by another sentence having the same truth-Value, Provided that the part as part has only customary reference and expresses a complete thought. The refutation proceeds by demonstrating this consequence to be false.

Doctors have been treating infectious diseases for hundreds of years, but the risk they and other medical professionals are exposed to in an epidemic has always been high. At the front line of the present war against COVID-19, medical teams are endangering their lives as they continue to treat patients suffering from the disease. What is the degree of danger that a medical team must accept in the face of a pandemic? What are the theoretical justifications for these risks? This (...) article offers answers to these questions by citing opinions based on Jewish ethical thought that has been formulated down through the ages. According to Jewish ethics, the obligation to assist and care for patients is based on many commandments found in the Bible and on rulings in the Responsa literature. The ethical challenge is created when treating the sick represents a real existential danger to the caregivers and their families. This consideration is relevant for all dangerous infectious diseases and particularly for the coronavirus that has struck around the world and for which there is as yet no cure. Many rabbis over the years have offered the religious justifications for healing in a general sense and especially in cases of infectious diseases as they have a bearing on professional and communal obligations. They have compared the ethical expectations of doctors to those of soldiers but have not sanctioned taking risks where there is insufficient protection or where there is a danger to the families of the medical professionals. (shrink)

Mody and Carey (2016) investigated children's capacity to reason by the disjunctive syllogism by hiding stickers within two pairs of cups (i.e., there is one sticker in cup A or B, and one in cup C or D) and then showing one cup to be empty. They found that children as young as 3 years of age chose the most likely cup (i.e., not A, therefore choose B; and disregard C and D) and suggested that these children were representing the (...) dependent relationship between A and B by applying the logical operator “or”. However, it is possible that children succeeded using simpler strategies, such as avoiding the empty cup and choosing within the manipulated pair. We devised a new version of the task in which a sticker was visibly removed from one of the four cups so that 2.5- to 5-year-old children (N = 100) would fail if they relied on such strategies. We also included a conceptual replication of Mody and Carey's (2016) original condition. Our results replicated their findings and showed that even younger children, 2.5 years of age, could pass above chance levels. Yet, 2.5-, 3- and 4-year-olds failed the new condition. Only 5-year-old children performed above chance in both conditions and so provided compelling evidence of deductive reasoning from the premise “A or B", where “or” is exclusive. We propose that younger children may instead conceive of the relationship between A and B as inclusive “or” across both versions of the task. (shrink)

In recent years, more and more religious communities have been refusing to vaccinate their children, and in so doing are allowing diseases to spread. These communities justify resistance to vaccination on various religious grounds and make common cause with nonreligious communities who oppose vaccination for their own reasons. Today this situation is reflected primarily in the spread of measles, and vaccine hesitancy was identified by the World Health Organization as 1 of the top 10 global health threats of 2019. The (...) present article presents the religious and ethical arguments for the obligation within Jewish tradition to vaccinate all children. Apart from the obligation on parents to vaccinate their own children, it includes the ethical arguments based on Judaism that call for parents to become organized and force schools to refuse to accept children who have not been vaccinated and demand vaccination of those who have not been inoculated. (shrink)

In 2014 Bruers and Breckman addressed a series of subsidiary questions arising from the trolley problem and their answers. In this article I describe ancient and precedent treatments of some of these issues over thousands of years as found in Jewish literature and the original solutions that have been proposed throughout history by Jewish philosophers and legal scholars. I address questions that have been posed to Jewish halakhic authorities when two obligations clash — whether one may save the lives of (...) many at the cost of killing an individual — and discuss whether this is permitted in order to save lives or forbidden owing to the prohibition of murder. I also present new problems that have been introduced into the halakhic and philosophical discussions around the trolley problem in Jewish literature. (shrink)

ABSTRACTIn Jewish tradition, expectations of the ideal teacher are very high, especially because the teacher is a role model for the next generation. So how does one become an ideal teacher? What is the proper image of a teacher according to Jewish ethics? The present paper is an attempt to answer a series of questions about what makes an ideal teacher based on an analysis of hundreds of texts, including halachic rulings and responsa as well as documents that outline various (...) communities’ guidelines and demands. The Jewish texts make up the ethic mosaic that profiles the ideal teacher, who must work with the students as well as with their families. In view of the importance of the education as it has been understood by arbiters throughout the ages, we can appreciate why there should be zero tolerance for mistakes and inadequacies. (shrink)

This book initiates the discussion between psychoanalysis and recent humanist and social scientific interest in a fundamental contemporary topic – the nonhuman. The authors question where we situate the subject in current critical investigations of a nonanthropoentric universe. In doing so they unravel a less-than-human theory of the subject; explore implications of Lacanian teachings in relation to the environment, freedom, and biopolitics; and investigate the subjective enjoyments of and anxieties over nonhumans in literature, film, and digital media. This innovative volume (...) fills a valuable gap in the literature, extending investigations into an important and topical strand of the social sciences for both analytic and pedagogical purposes. (shrink)

Hegel, Georg Wilhelm Friedrich; 1770-1831; criticism and interpretation; history; philosophy.

Taguergoust (Morocco), history; Cities and towns; Morocco; history.

Islam - Early works to 20th century ; Islamic ethics - Early works to 20th century.

One cannot deny the fact that we all have some understanding of moral issues. Each one of us can be said to have some sense of what is right, what is wrong, what is good, what is bad, what ought to be done, and what ought not to be done. This moral understanding can be in the form of some vague idea, notion, or simply a gut feeling. No matter who the person is, from which culture or community the person (...) belongs to, everybody faces a moral quandary sometime or other in one’s life. All of this presupposes that there is some fundamental sense or understanding of what is right and what is wrong. We all seem to have some understanding about actions that are right and those that are wrong. Some actions, for instance, torturing babies just for fun, killing an innocent person, raping, etc. are exemplars of morally wrong actions. Assisting a person in need, giving to famine relief, etc. on the other hand are examples of morally right actions. The present essay is an attempt to delve into the question of the source of moral knowledge. Three sources, experience, reason, and intuition have been identified. Views of philosophers like G.E Moore, WD Ross, Immanuel Kant, JS Mill, Plato, Samuel Clarke, Aristotle Hume, and Anthony Ashley Cooper have been discussed to gain clarity about the issue. (shrink)

Countless contracts have been undermined by the COVID-19 pandemic of 2020 as well as government orders to contain it. Flights have been canceled, concerts have been called off, and dorms have been closed, just to name a few. Do these all count as breaches of contract—or are the parties excused due to the extraordinary circumstances? And how should the losses be allocated between the parties? The law provides one set of answers to these questions; ethics offers another. With a focus (...) on American law and Jewish ethics, this paper shows that the two systems are in accord with some respects and differ in others: Both law and Jewish ethics would excuse a party who cannot complete his contract due to a force beyond his control, like the COVID-19 pandemic. Yet Jewish ethics would require that the excused party still be paid, while American law would not. (shrink)

Averroës, 1126-1198; criticism and interpretation; Islamic philosophy; Religion and ploitics.

An Arabic language summary of the history and principles of four key Hellenic schools of philosophy: Cynicism, Skepticism, Epicureanism, and Stoicism.

The article seeks to highlight the relation between ontology and communication while considering the role of AI in society and environment. Bioinformationalism is the technical term that foregrounds this relationality. The study reveals instructive consequences for philosophy of technology in general and AI in particular. The first section introduces the bioinformational approach to AI, focusing on three critical features of the current AI debate: ontology of information, property-based vs. relational AI, and ontology vs. constitution of AI. When applied to the (...) themes of relationality and non-anthropocentric communications, bioinformational insights highlight an inclusive and meaningful groundwork for understanding AI by ‘relating’ it with society and the environment through an engagement with the ongoing critique of human supremacy. In the second section, we move from ‘relating’ AI to ‘rewilding’ AI by proposing taxonomical classification for certain technological entities. We situate our proposal in the broader personhood debate with the proposal of taxonomical ranking. In the last section, we show an instance of a relational approach steeped in substantialist ontology by introducing the fourth feature of the AI debate. A broad critique of Floridi’s philosophy of information introduces this fourth feature from the domain of philosophy and sociology to address various theoretical and ecological problems with current relational accounts. In doing so, we argue for ‘communication’ to be the replacement of ‘information’ as the moral unit. A bioinformational understanding of AI advocates taking ontological commitments seriously at all levels of informational and technological processes and products. (shrink)

The mind maps symbols and the extra-symbolic relationships amongst them to specific meanings. When symbols of various levels are placed in a hierarchical ordering, one may look at such ordered classes as distinct worlds where one class represents objects and the other represents the objects’ corresponding meanings. However, such an explanation can only be partial because the number of potential levels in such an ordering is infinite and, therefore, it engenders problems of recursion and infinite regress. There are also logical (...) problems in the form of paradoxes that emanate from the consideration of sets of sets. Given that most prior studies only consider symbols that are classical objects in associative relationships, we argue that there is a need to also consider objects with shifting boundaries and quantum objects. We believe that objects belonging to each of these three classes—that is classical objects, objects with shifting boundaries, and quantum objects—play a role in the workings of the mind. (shrink)

Anthropocene jurisprudence amounts to a legal attitude that posits human beings as the ultimate subject to which the legal ontology, epistemology, and language serve. This attitude inevitably leads to exceptionalism not only in terminology but also in the impact which legal verdicts incur, especially on the natural environment and species. In this paper, we make a coupled reading of jurisprudence and environmental science while suggesting a post-Anthropocene model of law which can be made philosophically consistent by appropriating a new theory (...) of human as a 'biocultural creature' to outgrow the attitude of exceptionalism in law. In doing so, we take recourse of dynamic systems and complexity theory for a law to account for the ontology, epistemology and linguistics of post-Anthropocene jurisprudence. (shrink)

This essay uses Freudian–Lacanian psychoanalytic theory to interpret Hassan Blasim’s short story “The Nightmares of Carlos Fuentes”. Blasim’s story depicts the psychological struggles of an Iraqi emigrant relating to his embattled sense of belonging in a Dutch society due to the recurrent nightmares of his “traumatic” past. It challenges his assimilationist fantasies. I develop Lacan’s idea of ontological lack as a structural susceptibility that is exacerbated by actual experiences of trauma to underline how racialized refugees from the war-torn global South (...) are doubly vulnerable to experiencing subjective dehiscence between their efforts to forget past war traumas and the challenges of assimilating into (white) host nations. This essay uses Blasim’s story to illustrate a serious psychological issue experienced by racialized minority subjects in white/European host countries. (shrink)

Arabic literature; history and criticism.