The immune system can generate an almost infinite number of different antibody specificities, the sum of which is the antibody repertoire. This article considers aspects of the mechanism and control of immunoglobulin variable (V) region gene assembly with a focus on how these factors may affect generation of the antibody repertoire in normal and disease states. New model systems to study the mechanism and control of V gene assembly are described, in particular the introduction of V gene recombination substrates into (...) Abelson murine leukemia virus‐transformed pre‐B cells. Finally, a model is presented which suggests that control of V gene assembly is mediated by regulating accessibility of substrate gene segments to recombinational machinery. (shrink)

It is proposed that the multiple enhancer elements associated with locus control regions and super‐enhancers recruit RNA polymerase II and efficiently assemble elongation competent transcription complexes that are transferred to target genes by transcription termination and transient looping mechanisms. It is well established that transcription complexes are recruited not only to promoters but also to enhancers, where they generate enhancer RNAs. Transcription at enhancers is unstable and frequently aborted. Furthermore, the Integrator and WD‐domain containing protein 82 mediate transcription termination at (...) enhancers. Abortion and termination of transcription at the multiple enhancers of locus control regions and super‐enhancers provide a large pool of elongation competent transcription complexes. These are efficiently captured by strong basal promoter elements at target genes during transient looping interactions. -/- . (shrink)

While Deleuze and Guattari's Anti-Oedipus is quite rightly considered a fully fledged response to May ’68 and as one with the radical politics of the 1970s, their 1980 follow-up, A Thousand Plateaus, has tended to provoke a more perplexed reaction. In this article, I will argue that we can nonetheless extract a definite line of argumentation serving a precise political end if we relate the text back to Foucault's mid-1970s output on power/knowledge. In particular, I will emphasise Deleuze and Guattari's (...) appropriation of the Foucaultian notion of dispositif via their concept of the assemblage, the former being understood as a concrete articulation of lines of power, knowledge and subjectivation, as well as the Foucaultian ‘diagram’, the latter being a more abstract or indeterminate stage of the dispositif whose relative indeterminacy, for Deleuze and Guattari, offers a means of escape. I will show that, making room for the assemblage's opening back onto the relative indeterminacy of its generative stages, the assemblage incorporates into itself a more immanent alternative to the dispositif that is focused on collective desire rather than power, within which resistance becomes a primary and generative dimension rather than a counter-attack. In the first section, I will outline Foucault's approach to power, knowledge and subjectivation, emphasising Deleuze's reading of Foucault though without trying to overdetermine my reading in this way. Next, I will turn to the Foucaultian diagram. In the third section, I will focus on A Thousand Plateaus, demonstrating how the notion of assemblage developed in this text responds to and builds upon Foucault's approach to power/knowledge and subjectivation in order to reconceive resistance. (shrink)

The thymus is a unique primary lymphoid organ that supports the production of self‐tolerant T‐cells essential for adaptive immunity. Intrathymic microenvironments are microanatomically compartmentalised, forming defined cortical, and medullary regions each differentially supporting critical aspects of thymus‐dependent T‐cell maturation. Importantly, the specific functional properties of thymic cortical and medullary compartments are defined by highly specialised thymic epithelial cells (TEC). For example, in the medulla heterogenous medullary TEC (mTEC) contribute to the enforcement of central tolerance by supporting deletion of autoreactive (...) T‐cell clones, thereby counterbalancing the potential for random T‐cell receptor generation to contribute to autoimmune disease. Recent advances have further shed light on the pathways and mechanisms that control heterogeneous mTEC development and how differential mTEC functionality contributes to control self‐tolerant T‐cell development. Here we discuss recent findings in relation to mTEC development and highlight examples of how mTEC diversity contribute to thymus medulla function. (shrink)

Once dismissed as vestigial organelles, primary cilia have garnered the interest of scientists, given their importance in development/signaling, and for their implication in a new disease category known as ciliopathies. However, many, if not all, “cilia” proteins also have locations/functions outside of the primary cilium. These extraciliary functions can complicate the interpretation of a particular ciliopathy phenotype: it may be a result of defects at the cilium and/or at extraciliary locations, and it could be broadly related to a (...) unifying cellular process for these proteins, such as polarity. Assembly of a cilium has many similarities to the development of other polarized structures. This evolutionarily preserved process for the assembly of polarized cell structures offers a perspective on how the cilium may have evolved. We hypothesize that cilia proteins are critical for cell polarity, and that core polarity proteins may have been specialized to form various cellular protrusions, including primary cilia. (shrink)

The architecture of cities provides infrastructures for thousands of people. Yet if it seems that the primary task of this architecture is to make the administration of many people, their living together, their work, their leisure, possible on a rational and dense basis, we ought not oversee that the fulfillment of these functions is not a sufficient condition of what makes a city. Important characteristics of urbanity rather enable the meeting of a multitude of people. Cities count among the (...) conditions for social events insofar as they assemble. In my paper, I propose to analyze this architectural condition as the decisive difference between »Being With« in contrast to just »Being next to«. (shrink)

The architecture of cities provides infrastructures for thousands of people.Yet if it seems that the primary task of this architecture is to make the administration of many people, their living together, their work, their leisure, possible on a rational and dense basis, we ought not oversee that the fulfillment of these functions is not a sufficient condition of what makes a city. Important characteristics of urbanity rather enable the meeting of a multitude of people. Cities count among the conditions (...) for social events insofar as they assemble. In my paper, I propose to analyze this architectural condition as the decisive difference between »Being With« in contrast to just »Being next to«. (shrink)

Integral membrane proteins are found in all cellular membranes and fulfil many of the functions that are central to life. A critical step in the biosynthesis of membrane proteins is their insertion into the lipid bilayer. The mechanisms of membrane protein insertion and folding are becoming increasingly better understood, and efficient methods for the ab initio prediction of three‐dimensional protein structure from the primary amino acid sequence may be within reach. Already, the basic tools needed for engineering and de (...) novo design of integral membrane proteins seem to be at hand. (shrink)

The autophagy initiation complex is brought about via a highly ordered and stepwise assembly process. Two crucial signaling molecules, mTORC1 and AMPK, orchestrate this assembly by phosphorylating/dephosphorylating autophagy‐related proteins. Activation of Atg1 followed by recruitment of both Atg9 vesicles and the PI3K complex I to the PAS (phagophore assembly site) are particularly crucial steps in its formation. Ypt1, a small Rab GTPase in yeast cells, also plays an essential role in the formation of the autophagy initiation complex through multiple regulatory (...) pathways. In this review, our primary focus is to discuss how signaling molecules initiate the assembly of the autophagy initiation complex, and highlight the significant roles of Ypt1 in this process. We end by addressing issues that need future clarification. (shrink)

Human-robot collaboration, whereby the human and the robot join their forces to achieve a task, opens new application opportunities in manufacturing. Robots can perform precise and repetitive operations while humans can execute tasks that require dexterity and problem-solving abilities. Moreover, collaborative robots can take over heavy-duty tasks. Musculoskeletal disorders (MSDs) are a serious health concern and the primary cause of absenteeism at work. While the role of the human is still essential in flexible production environment, the robot can help (...) decreasing the workload of workers. This paper describes a novel framework for task allocation of human-robot assembly applications based on capabilities and ergonomics considerations. Capable agents are determined on the basis of agent characteristics and task requirements. Ergonomics is integrated by measuring the human body posture and the related workload. The developed framework was validated on a gearbox assembly use case using the collaborative robot Baxter. (shrink)

This essay explores the debate concerning the idea of democracy in the French Revolution. It shows that this idea is based upon representative democracy as well as direct democracy, maintaining a complex and precarious equilibrium between the two. It investigates the different political-institutional means used in those years, the parliamentary debates and the three constitutions, focusing on concepts such as representation, electoral mandate and primary assemblies. Representative democracy and direct democracy turn out to be neither distant from nor (...) alternative to each other, but interdependent and mutual. (shrink)

In _ Plato's Camera_, eminent philosopher Paul Churchland offers a novel account of how the brain constructs a representation -- or "takes a picture" -- of the universe's timeless categorical and dynamical structure. This construction process, which begins at birth, yields the enduring background conceptual framework with which we will interpret our sensory experience for the rest of our lives. But, as even Plato knew, to make singular perceptual judgments requires that we possess an antecedent framework of abstract categories to (...) which any perceived particular can be relevantly assimilated. How that background framework is assembled in the first place is the motivating mystery, and the primary target, of Churchland's book. Unexpectedly, this neurobiologically grounded account of human cognition also provides a systematic story of how such low-level epistemological activities are integrated within an enveloping framework of linguistic structures and regulatory mechanisms at the social level. As Churchland illustrates, this integration of cognitive mechanisms at several levels has launched the human race on an epistemological adventure denied to all other terrestrial creatures. (shrink)

In _ Plato's Camera_, eminent philosopher Paul Churchland offers a novel account of how the brain constructs a representation -- or "takes a picture" -- of the universe's timeless categorical and dynamical structure. This construction process, which begins at birth, yields the enduring background conceptual framework with which we will interpret our sensory experience for the rest of our lives. But, as even Plato knew, to make singular perceptual judgments requires that we possess an antecedent framework of abstract categories to (...) which any perceived particular can be relevantly assimilated. How that background framework is assembled in the first place is the motivating mystery, and the primary target, of Churchland's book. Unexpectedly, this neurobiologically grounded account of human cognition also provides a systematic story of how such low-level epistemological activities are integrated within an enveloping framework of linguistic structures and regulatory mechanisms at the social level. As Churchland illustrates, this integration of cognitive mechanisms at several levels has launched the human race on an epistemological adventure denied to all other terrestrial creatures. (shrink)

This is the first critical edition ever produced of Essays, Moral, Political, and Literary by David Hume, who is widely widely considered to be the most important British philosopher and an author celebrated for his moral, political, historical, and literary works. The editors' Introduction is primarily historical and written for advanced students and scholars from many disciplines. It is neither an orientation to Hume's philosophy nor an introduction aimed at philosophers. It is not an attempt to interpret Hume's text, but (...) rather discusses the genesis, revision, and reception of the essays, which went into many editions at the author's hand. The annotations provide information about Hume' s sources, allusions, and citations, as well as background facts pertinent to an informed reading of the essays. The primary goal is to aid readers in their interpretations of the text. This edition also includes a detailed commentary on Hume's essay 'On the Populousness of Ancient Nations', which will be of special interest to ancient historians. The two volumes present a full critical edition, in every respect. They assemble a massive amount of historical and textual information never previously published. The editorial apparatus is comprehensive and includes extensive historical and bibliographical detail. The Clarendon Edition of the Works of David Hume as a whole is on the cutting-edge of editorial work in the history of great works in the eighteenth century. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Willing and Nothingness: Schopenhauer as Nietzsche's EducatorDaniel SchumanChristopher Janaway, Editor. Willing and Nothingness: Schopenhauer as Nietzsche's Educator. New York: Oxford University Press, 1999. Pp. 293. Cloth, $65.00.Considering how many English language studies of Nietzsche's thought exist, it is quite remarkable that more has not been written on the question of the influence that Arthur Schopenhauer, his self-described "educator," had on his philosophy. The essays in this important volume (...) go a long way toward filling this vacancy in Nietzsche (and Schopenhauer) scholarship. Christopher Janaway has assembled an impressive group of articles that, taken together, effectively reveal the complexity and depth of Nietzsche's Schopenhauerian inheritance. This collection is both focused and comprehensive. These essays deal with almost all of the major points of agreement and contention between these two philosophers without exaggerating the influence of Schopenhauer on Nietzsche.In his introduction and contributing essay, Janaway highlights some of the general ways in which Schopenhauer exerted an influence on Nietzsche throughout his philosophical development. Janaway argues that despite Nietzsche's steadfast rejection of Schopenhauer's metaphysics there are important ways in which he remained indebted to his mentor even in his later works. For instance, though Schopenhauer embraces the mystical ideal of freeing the intellect from the will, it is his view that in the phenomenal realm the intellect is essentially an instrument of the will. According to Janaway, this claim that the intellect must be "rooted in a living, striving entity" had a profound [End Page 133] influence on Nietzsche's later thought, especially on his 'perspectivism' (35). The second essay in this volume, contributed by Maudemarie Clark, makes the similar claim that Nietzsche's ideas regarding truth and knowledge are grounded in the naturalistic conception of intellect he inherited from Schopenhauer. Clark claims Schopenhauer's philosophy, once divested of its more extreme metaphysical aspects, can be understood as a form of empiricism in which all knowing is "rooted in affect" (74). This is an idea that Clark also takes to be at the heart of Nietzsche's perspectivism.Other essays deal with two issues that were of primary importance to both Schopenhauer and Nietzsche: aesthetics and morality. Ivan Soll compares their respective aesthetic theories and argues that their views regarding the significance of art are not as dissimilar as Nietzsche himself claimed. They both see art "through the lens of life" and as a way of responding to the suffering that characterizes human existence. However, whereas Schopenhauer sees art as a means of denying the will to life, Nietzsche sees it as means of affirming life in the face of suffering. Like Soll, David Cartwright argues that Nietzsche embraces Schopenhauer's stance on the pervasiveness of suffering in human life. From this standpoint he examines both Nietzsche's criticisms and appropriation of certain elements of Schopenhauer's moral philosophy. Cartwright cleverly argues that Nietzsche's scathing critique of Schopenhauer's asceticism and morality of Mitleid actuallyrelies upon Schopenhauer's methodology and incorporates elements of his pessimism.Pessimism is dealt with in more detail in the essays by Kathleen Higgins and David Berman. Higgins claims that Schopenhauer's and Nietzsche's basic conceptions of will are actually quite similar. Both philosophers understand and interpret life in fundamentally voluntaristic terms. However, the two philosophers part ways when it comes to how will is characterized. Schopenhauer's pessimism and Nietzsche's relative optimism, Higgins claims, spring more from a difference in the temperament of the two thinkers, rather than a difference in their conceptions of will. In his essay, David Berman reinforces Higgins' view that Schopenhauer and Nietzsche share the same basic understanding of will even though their evaluations of it differ. However, Berman claims that Nietzsche came to see Schopenhauer as a closet epistemological optimist whose purported pessimism was "being used to protect and insulate him from the world's pain" (190). It is Berman's view that Nietzsche's self-proclaimed recognition of Schopenhauer's pessimism as a kind of "self-deceived" optimism actually cleared the way for Nietzsche to develop his philosophy of power and life affirmation. Whereas Schopenhauer retreats into the false comfort of resignation and denial, Nietzsche's... (shrink)

In this paper, I review a collection of recently published papers that have provided significant new information about the biogenesis and functions of motile cilia. In vertebrates, the activity of motile cilia has been associated with a fascinating diversity of developmental and physiological processes. Despite the importance, much remains to be learned about the genetic control and cellular events that are involved in the differentiation of motile cilia. We also need to better understand the mechanisms by which cilia‐driven fluid flow (...) is able to influence such a variety of developmental and physiological processes. The Foxj1 family of proteins has now been definitively established as master regulators of motile ciliogenesis.1,2 Identification of the Kintoun/PF13 protein has shed light on the assembly of dynein arms,3 whereas live imaging of ciliary motility has led to the discovery of an intriguing new role for motile cilia in otolith formation in the ear.4. (shrink)

This is the most comprehensive and authoritative English-language anthology of primary source material on Korean civilization ever assembled. Encompassing social, intellectual, religious, and literary traditions, this volume covers the seventeenth century to the modern period. Contemporary histories, social documents, Buddhist scripture, philosophical treatises, and popular literature selected for this book reflect the dynasties and eras that helped fashion the late Choson (1600-1860) and Modern (1860-1945) periods.

Pippin has assembled a number of independent pieces into a volume to complement his Modernism as a Philosophical Problem. His primary thesis is that Hegel and German Idealism generally offer an approach to modernism which both avoids the subjectivism and mentalism of Descartes and is strong enough to resist the attacks of Habermas, Strauss, Blumenberg, Nietzsche, and Heidegger.

I use the collection of “carnal ethnographies” of martial arts and combat sports assembled by Raul Sanchez and Dale Spencer under the title Fighting Scholars to spotlight the fruitfulness of deploying habitus as both empirical object (explanandum) and method of inquiry (modus cognitionis). The incarnate study of incarnation supports five propositions that clear up tenacious misconceptions about habitus and bolster Bourdieu’s dispositional theory of action: (1) far from being a “black box,” habitus is fully amenable to empirical inquiry; (2) the (...) distinction between primary (generic) and secondary (specific) habitus enables us to capture the malleability of dispositions; (3) habitus is composed of cognitive, conative and affective elements: categories, skills, and desires; (4) habitus allows us to turn carnality from problem to resource for the production of sociological knowledge; and (5) thus to realize that all social agents are, like martial artists, suffering beings collectively engaged in embodied activities staged inside circles of shared commitments. (shrink)

This essay presents a point of view for looking at `free will', with the purpose of interpreting where exactly the freedom lies. For, freedom is what we mean by it. It compares the exercise of free will with the making of inferences, which usually is predominantly inductive in nature. The making of inference and the exercise of free will, both draw upon psychological resources that define our ‘selves’. I examine the constitution of the self of an individual, especially the involvement (...) of personal beliefs, personal memories, affects, emotions, and the hugely important psychological value-system, all of which distinguish the self of one individual from that of another. The foundational position that adopted in this essay is that all psychological processes are correlated with corresponding ones involving large scale neural aggregates in the brain, communicating with one another through wavelike modes of excitation and de-excitation. Of central relevance is the value-network around which the affect system is organized, the latter, in turn, being the axis around which is assembled the self, with all its emotional correlates. The self is a complex system. I include a brief outline of what complexity consists of. In reality all systems are complex, for complexity is ubiquitous, and certain parts of nature appear to us to be ‘simple’ only in certain specific contexts. It is in this background that the issue of determinism is viewed in this essay. Instead of looking at determinism as a grand principle entrenched in nature independent of our interpretation of it, I look at our ability to explain and to predict events and phenomena around us, which is made possible by the existence of causal links running in a complex course that set up correlations between diverse parts of nature, in this way putting the stamp of necessity on these events. However, the complexity of systems limits our ability to explain and to predict to within certain horizons defined by contexts. Our ability to explain and predict in matters relating to acts of free will is similarly limited by the operations of the self that remain hidden from our own awareness. The aspects of necessity and determinism appear to us in the form of reason and rationality that explain and predict only within a limited horizon, while the rest depends on the complex operation of self-linked psychological resources, where the latter appear as contingent in the context of the exercise of free will. The hallmark of complex systems is the existence of amplifying factors that operate as destabilizing ones, along with inhibiting or stabilizing factors as well that generally limit the destabilizing influences to local occurrences, while preserving the global integrity of a system. This complex interplay of destabilizing and stabilizing influences lead to the possibility of an enormous number of distinct modes of behavior that appear as emergent phenomena in complex systems. Looking at the particular case of the self of an individual that guide her actions and thoughts, it is the operation of our emotions, built around the psychological value-system, that provide for the amplifying and inhibiting factors mentioned above. The operation of these self-linked factors stamps our actions and thoughts as contingent ones that do not fit with our concepts of reason and rationality. And this is what provides the basis of our idea of free will. Free will is not ‘free’ in virtue of exemption from causal links running through all our self-based processes - ones that remain hidden from our awareness, but is free of what is perceived to be ‘reason and rationality’ based on knowledge and the common pool of beliefs and principles associated with a shared world-view. When we speak of the choice involved in an act of exercise of free will what we actually refer to is the commonly observed fact that various different individuals of a similar disposition respond differently when placed under similar circumstances. In other words, free will is ‘free’ precisely because it is not subject to constraints of a commonly accepted and shared set of principles, beliefs, and values. While it is possible that, in an exercise of free will, the self-linked psychological resources are brought into action when a number of alternatives are presented to the self by the operation of the ingredients of a commonly shared world-view, it seems likely that, that set of alternatives is not of primary relevance in the final response that the mind produces, since the latter is primarily a product of the operation of the self-based psychological resources. What is of greater relevance here is the operation of emotion-driven processes, guided by the psychological value-system based on the activity of the so-called reward-punishment network in the brain. These processes lead the individual to a response that appears to be free from the shackles of determinism precisely because their mechanisms, which are hidden from us, do not conform to commonly accepted and shared rules and principles. In contrast, inductive inference is a process that is based on the ‘cognitive face’ of self, where the self-based psychological resources play a supportive role to the commonly shared world-view of an individual. There is never any freedom from the all-pervading causal links representing correlations among all objects, entities, and events in nature. In the midst of all this, the closest thing to freedom that we can have in our life comes with self-examination and self-improvement. The possibility of self-examination appears in the form of specific conjunctions between our complex self-processes and the ceaseless changes of scenario in our external world. This actually makes the emergent phenomenon of self-examination a matter of chance, but one that keeps on appearing again and again in our life. Once realized, self examination creates possibilities that would not be there in the absence of it, and these possibilities include the enhancement of further self-enrichment and further diversity in the exercise of our free will. (shrink)

Empirical results suggest that defocusing attention results in primary process or associative thought, conducive to finding unusual connections, while focusing attention results in secondary process or analytic thought, conducive to rule-based operations. Creativity appears to involve both. It is widely believed that it is possible to escape mental fixation by spontaneously and temporarily engaging in a more divergent or associative mode of thought. The resulting insight may be refined in a more analytic mode of thought. The question addressed here (...) is: how does the architecture of memory support these two modes of thought, and what is happening at the neural level when one shifts between them? Recent advances in neuroscience shed light on this. It was demonstrated that activated cell assemblies are composed of multiple ‘neural cliques’, groups of neurons that respond differentially to general or context-specific aspects of a situation. I refer to neural cliques that would not be included in the assembly if one were in an analytic mode, but would be if one were in an associative mode, as ‘neurds’. It is posited that the shift to a more associative mode of thought conducive to insight is accomplished by recruiting neurds that respond to abstract or atypical subsymbolic microfeatures of the problem or situation. Since memory is distributed and content-addressable this fosters remindings and the forging of creative connections to potentially relevant items previously encoded in those neurons. Thus it is proposed that creative thought involves neither randomness, nor search through a space of predefined alternatives, but emerges naturally through the recruitment of neurds. It is suggested this occurs when there is a need to resolve conceptual gaps in ones’ internal model of the world, and resolution involves context-driven actualization of the potentiality afforded by its fine-grained associative structure. (shrink)

In a study drawing from both evolutionary biology and the social sciences, evidence and argument is assembled in support of the comprehensive appli- cation of selfish gene theory to the human population. With a focus on genes giving rise to characteristically-human cooperation (“cooperative genes”) in- volving language and theory of mind, one may situate a whole range of pat- terned behaviour—including celibacy and even slavery—otherwise seeming to present insuperable difficulties. Crucially, the behaviour which tends to propa- gate the cooperative genes (...) may be “at cost” to the genes of some who may be party to the cooperation itself. Explanatory insights are provided by Trivers’ parent-offspring conflict theory, Lack’s principle, and Hamilton’s kin selec- tion mechanism. A primary observation is that cooperation using language and theory of mind is itself interdependent with full human conceptualization of a world of objects and of themselves as embodied beings. Human capaci- ties inhering in, or arising out of, the ability to cooperate are also responsible for a vitally important long-term process, the domestication of animals and p- lants. The approach illuminates the difference between animal and human sexual behaviour, and the emergence of kinship systems. Again, recent pat- terns of population growth become much more explicable. It is argued that the gene is the single controlling replicator; the notion of the meme as a sec- ond independent replicator is flawed. (shrink)

This text The Apostolic Church: from the “Tent of God for Salvation and Healing” to the “Church of the Santa Vó Rosa” - Religious Mutations aims to describe the emergence and mutations experienced by an initially Pentecostal Church, founded in São Paulo, in 1954, in the wake of the divine healing movement. We try to answer the question: Given these changes experienced over the course of six decades, what of Pentecostal features remained at the end of this trajectory marked by (...) doctrinal, liturgical and administrative transformations? In the research, were examined: primary documentation; minutes of assemblies registered at notary offices; Church websites and bulletins; television documentaries and other documents posted on Youtube; newspapers; and electronic files produced by former members and pastors some years ago against the leadership of this Church. The data obtained lead us to the conclusion that the changes implemented are sufficient to classify this Church as a sect-type institution because of the closure in itself, the rigor of its discipline, of its eschatological emphasis and of its anticultural position. The Apostolic Church today maintains only a few remnants of its Pentecostal origins. (shrink)

Cilia are unique eukaryotic organelles and exhibit remarkable conservation across evolution. Nevertheless, very different types of configurations are encountered, raising the question of their evolution. Cilia are constructed by intraflagellar transport (IFT), the movement of large protein complexes or trains that deliver cilia components to the distal tip for assembly. Recent data revealed that IFT trains are restricted to some but not all nine doublet microtubules in the protist Trypanosoma brucei. Here, we propose that restricted positioning of IFT trains could (...) offer potent options for cilia to evolve towards more complex (addition of new structural elements like in spermatozoa) or simpler configuration (loss of some elements like in primary cilia), and therefore be a driver of cilia diversification. We present two hypotheses to explain how IFT trains could be restricted to some doublets, either by a triage process taking place at the basal body level or by the development of molecular differences between ciliary microtubules. (shrink)

Arthâpatti is a pervasive form of reasoning investigated by Indian philosophers in order to think about unseen causes and interpret ordinary and religious language. Its nature is a point of controversy among Mimamsa, Nyaya, and Buddhist philosophers, yet, to date, it has received less attention than perception, inference, and testimony. This collection presents a one-of-a-kind reference resource for understanding this form of reasoning studied in Indian philosophy. Assembling translations of central primary texts together with newly-commissioned essays on research topics, (...) it features a significant introductory essay. Readable translations of Sanskrit works are accompanied by critical notes that introduce arthâpatti, offer historical context, and clarify the philosophical debates surrounding it. Showing how arthâpatti is used as a way to reason about the basic unseen causes driving language use, cause-and-effect relationships, as well as to interpret ambiguous or figurative texts, this book demonstrates the importance of this epistemic instrument in both contemporary Anglo-analytic and classical Indian epistemology, language, and logic. (shrink)

The Erfurtensis , now lat. 2°.252 in the Staatsbibliothek Preuβischer Kulturbesitz at Berlin , was assembled by Wibald of Corvey in the mid twelfth century, and is the most comprehensive medieval manuscript of Cicero, containing nearly half of what was eventually to survive. The manuscript as it exists today has lost one or more folios at several different points, but in some of these places readings were recorded by sixteenth and seventeenth-century scholars before the mutilations occurred. There is, however, only (...) one lacuna where early collations survive and where, also, E is a manuscript of primary importance for the reconstruction of the text. The omission in question, caused by the removal of folios at some unknown date between the beginning of the seventeenth century and the early nineteenth century, comprises the end of pro Caecina and virtually all pro Sulla . No readings are known to have been taken from the end of pro Caecina, but from the bulk of pro Sulla, before the manuscript as we have it resumes, a sizeable number of readings has fortunately been preserved. The tradition of pro Sulla takes the form of two branches, one consisting of Munich, Bayer. Staatsbibliothek, Clm 18787, olim Tegernseensis, and all the deteriores , the other consisting of just two manuscripts, E and its twin, Vatican, Pal. lat. 1525 . V comes to a halt at §43; the early collations of E are therefore of the highest importance for pro Sulla until §81, especially from §43 onwards where they comprise our only record for one of the tradition's two branches. (shrink)

In 1946 there were three democracies in the world with constitutions that, on the one hand, required the government to obtain the support of a legislative majority in order to come to and remain in power and, on the other hand, established a popularly elected president. In 2002, this number had grown to 25. Constitutions with this feature are often considered to be problematic, and, given the number of new democracies that have adopted them, have received considerable attention from political (...) scientists. The primary concern has to do with the potential for conflict between the assembly supported government and the popularly elected president, which may lead to unstable governments, policy paralysis, and the eventual undermining of the democratic regime. Concern has also been raised regarding the negative role a popularly elected president may have on party development and the that in a pure parliamentary democracy runs from voters to government through political parties. In this paper, we examine the effect the combination of assembly confidence with a popularly elected president has on government instability, accountability, legislative effectiveness, and democratic survival. We also examine the impact on these outcomes of different combinations of presidential powers. We find that the introduction of a popularly elected president in parliamentary constitutions is of little significant impact and that the preoccupation with the specific powers of the president is mostly overblown. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Philosophy 39.1 (2001) 158-159 [Access article in PDF] Christopher Janaway, editor. The Cambridge Companion to Schopenhauer. New York: Cambridge University Press, 1999. Pp. 592. Cloth, $59.95. Schopenhauer's import as a original thinker has often been downplayed or underestimated by contemporary commentators and his philosophy is often examined only in light of his influence upon Nietzsche. This collection of thirteen essays assembled by Christopher Janaway (...) does much to overcome scholarly neglect of Schopenhauer by illustrating the original aspects of his thought as well as the widespread influence his philosophy has had. One gains from this book not only a solid introduction to Schopenhauer's major ideas but an appreciation of the significant contributions he made to the philosophical milieu of the nineteenth and twentieth centuries.In the first essay, Gunter Zöller examines how Schopenhauer's unique notion of selfhood fits into his overall "dual aspect" theory of the world as both will and representation. He also discusses Schopenhauer's conception of the self within the context of his claims regarding the negation of the will. The following article, by David Hamlyn, is also broad in scope and provides a comprehensive examination of Schopenhauer's epistemology in The World as Will and Representation. He looks at the various notions of knowledge that are employed in Schopenhauer's system and how they are determined by the different classes of objects of knowledge that Schopenhauer distinguishes. In the third essay F. C. White turns to Schopenhauer's earlier work, On the Fourfold Root of the Principle ofSufficient Reason. White runs through Schopenhauer's arguments regarding each of the four classes of objects which comprise the world as representation in the Fourfold Root. He reinforces the point made by Schopenhauer himself, that this is a text that can not be overlooked if one is to gain a sufficient understanding of his primary work. The Fourfold Root, like the rest of Schopenhauer's philosophy, is deeply engaged with the philosophy of Kant. This is the topic of the next article by Paul Guyer. Guyer gives a detailed summary and evaluation of Schopenhauer's appropriation and critique of Kant's theoretical philosophy. According to Guyer, Schopenhauer and Kant employ quite different methodologies, Kant's being thoroughly transcendental and Schopenhauer's more phenomenological. Also, Schopenhauer's phenomenological approach to epistemological questions often skews his interpretation and evaluation of Kant's transcendental arguments. [End Page 158]Christopher Janaway, in the first of his two contributions, turns the focus to Schopenhauer's famous metaphysical doctrine of the will. He provides a particularly illuminating discussion of Schopenhauer's conception of will as the "thing-in-itself." The thing-in-itself is also the subject of the next article by Noira Nichols. Despite his reputation for not significantly altering his major positions, Nichols argues that there is a distinct difference between Schopenhauer's earlier, more Kantian, conception of the thing-in-itself with his later, more mystical, conception. She attributes these conceptual shifts to the increasing influence of Eastern philosophy upon Schopenhauer's thinking. Schopenhauer's broad analysis of the concept of will includes complex aesthetic and moral theories which are addressed in the contributions by Cheryl Foster and David Cartwright. In her contribution, Cheryl Foster examines Schopenhauer's aesthetics by focusing on his views regarding the relationship of art and science, art and the limitations of the intellect, and the nature of artistic genius. Turning to Schopenhauer's moral theory, David Cartwright explicates Schopenhauer's "narrower" sense of morality as discussed in his often overlooked On the Basis of Morality, rather than focusing on the "higher metaphysical-ethical standpoint" exemplifed in the World as Will and Representation. Cartwright also attempts to demonstrate "... how Schopenhauer has contributed and could contribute to contemporary moral thought" (253).The next group of articles address the issue of Schopenhauer's pessimism. Dale Jacquette looks at Schopenhauer's understanding of the meaning of death in light of his pessimistic metaphysic. Included in Jacquette's study is an explanation of Schopenhauer's views on suicide and asceticism. Covering similar territory, Christopher Janaway... (shrink)

*PSA 2016, symposium on “Data in Time: Epistemology of Historical Data” organized by Sabina Leonelli, 5 November 2016* *See published version: "Radiocarbon Dating in Archaeology: Triangulation and Traceability" in Data Journeys in the Sciences (2020) - link below* Archaeologists put a premium on pressing “legacy data” into service, given the notoriously selective and destructive nature of their practices of data capture. Legacy data consist of material and records that been assembled over decades, sometimes centuries, often by means and for purposes (...) long since discredited or superseded. The primary strategies by which archaeologists put the data to work for new purposes are, I argue, secondary retrieval, recontextualization, and experimental modelling. I focus here on a particularly telling and complex example of secondary retrieval: the extraction of new data from old by means of radiocarbon dating. This is by no means a straightforward process of retrieving physical samples from legacy data to which 14C techniques can be applied that can, on their own, decisively settle chronological questions. When Libby’s post-war radiocarbon revolution got under way, it was expected to establish an absolute chronology that would render obsolete the local and relative chronologies on which archaeologists had long relied. Transformative though it has been, bringing these tools of physical dating to bear on archaeological problems has been a long, tortuous process, now described as proceeding through two subsequent radiocarbon revolutions. The second was an extended process of calibration by which 14C chronologies were corrected and refined, often against the very lines of evidence they were meant to displace. The most recent, a “pragmatic Bayesian” approach to archaeological dating, is motivated by concern that, no matter how much it is refined, radiocarbon dating cannot on its own resolve the chronological problems that archaeologists address; the challenge, its advocates argue, is to ‘fully integrate archaeological information with 14C dating in order to address archaeologically relevant timescales and episodes’. This is a genre of “robustness” reasoning that illustrates its epistemic risks as well as its appeal. As recent philosophical debate makes clear, it depends on appeals to the convergence of independent lines of evidence that may have more rhetorical than epistemic force and that may be spurious. Drawing on this philosophical literature I identify a set of conditions that must be met if these risks are to be avoided, all of which are an explicit focus of debate in cases of contestation about and reconciliation of chronologies based on legacy data. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Listening In: Music, Mind, and the Modernist NarrativeRandall Everett AllsupEric Prieto, Listening In: Music, Mind, and the Modernist Narrative ( Lincoln NE: University of Nebraska Press, 2002)Modernism. The Interpretation of Dreams, the assembly line, The Rite of Spring, the Panama Canal. The modernist sensibility is characterized above all by the "willful big idea"—history as text, a manifesto in conflict with itself and its past. Hopeful and revolutionary like (...) the writings of Karl Marx or progressive and corrupt like the Manhattan Project, such events-as-manifesto had a way of feeding off each other. Through collaboration, conflict, and competition, modernists from Robert Moses to Elliott Carter raced to explain and exemplify, often deliberately creating conflict as if crisis were its own rationale, its own sine qua non. One could hypothesize that this arms race of complexity collapsed—exhausted—about the same time that Communism did. Its failure to sustain its ideas (rather than outpace them one after another) may be one reason we live in an anti-dialectical world, an unmodern place of fundamentalisms and easy freedoms.Author Eric Prieto is at home in the modern world more so than the present; his heroes are French intellectuals after all, those lovers of complexity. In Listening In: Music, Mind, and the Modernist Narrative, he investigates late modernist authors who looked to music as a way to exemplify the inward nature of mind [End Page 93] and the outward nature of place. To understand this book, we must revisit some formal aesthetic theories, namely that music's value resides in its ability to name without signifying, that musical properties like intervallic distance, dynamic contrast, and the space-time component that is rhythm put us in touch with the Kantian a priori—the-thing-in-itself, the Schopenhauerian will. Music as sound-in-itself (to riff on Kant and Schopenhauer) becomes a metaphor for the noumenal world or is mimetic at the very least of the abstract and non-linear nature of thought. Prieto argues that "wherever a music model is present [among his examples] it always serves to further this inwardly directed mode of mimesis I call 'listening in,' where the primary object of representation is not the outside world but the subtly modulating interactions between consciousness and world."1Prieto's book is highly consistent. He masterfully captures the spirit of cooperation from modernist writer to musician to thinker and back. Concentrating on three authors, Robert Pinget, Michel Leiris, and Samuel Beckett, Prieto cites the influences of composers like Bach and Beethoven, as well as philosophers like Wittgenstein and Schopenhauer on their literary works. He brings in thinking from Nelson Goodman and Ferdinand de Saussure. The result is literary criticism as manifesto. Reader beware, this is a book for an elevated audience, those rare folk who are comfortable with structural linguistics, nineteenth-century music aesthetics, specialized academic scholarship, and word puzzles. To explain for example why an author like Beckett is inspired by music to create abstract or associative narratives rather than traditional stories of cause and effect, Prieto writes:In music, this progression necessarily takes place on the level of audible resemblances, but in literature, by virtue of the properties of the two-tiered linguistic sign, analogical progression may take place either on the level of the signifier (via the principle of paronomasia), on the level of the signified (via metaphorical substitutions, as in the association of ideas), or between the two levels (punning, "imitative harmony").2This density of language and concept speak well of Prieto's intellect and one is likewise impressed by his broad understanding of music and letters, yet it is the musical scholar who gets the short end of the deal. Paronomasia? "Audible resemblance" is not a musical term I have heard used. In Listening In: Music, Mind, and the Modernist Narrative, music serves as starting point, an inspiration, not as an equal partner. This holds true for Beckett and Pinget as well as for Prieto. The result can be disconcerting, even to readers like me for whom the cross-disciplinary study of music and literature is a fascinating endeavor.Difficulty, nonetheless, has its rewards and this is one lesson of... (shrink)

This book is unusual in many respects. It was written by a prolific author whose tragic untimely death did not allow to finish this and many other of his undertakings. It was assembled from numerous excerpts, notes, and fragments according to his initial plans. Zilberman’s legacy still awaits its true discovery and this book is a second installment to it after The Birth of Meaning in Hindu Thought (Kluwer, 1988). Zilberman’s treatment of analogy is unique in its approach, scope, and (...) universality for Western philosophical thought. Constantly compared to eastern and especially classical Indian interpretations, analogy is presented by Zilberman as an important and in many ways primary method of philosophizing or philosophy-building. Due to its universality, this method can be also applied in linguistics, logic, social analysis, as well as historical and anthropological research. These applications are integral part of Zilberman’s book. A prophetic leap to largely uncharted territories, this book could be of considerable interest for experts and novices in the field of analogy alike. (shrink)

This essay assesses Quentin Meillassoux’s numerological approach to Mallarmé’s problematic but formally innovative poem “Un Coup de dés,” using a semiotic methodology to reveal the deficiencies of that approach from the viewpoint of literary theory. Section 1 describes my expanded version of Michael Riffaterre’s semiotic theory of the structure of modern poetry. Poems are generated by two underlying propositions, each of which governs the structure of a set of symbolic images on the textual surface. These “matricial” propositions are linked by (...) a syntagmatic relation. The primary text functions as subject-sign of the Peircean semiotic triad; its object-sign is an intertextual model. The interpretant of these two textual signs is assembled by the reader and has a sociolectic counterpart – or context – which has similar lexical content but contrasting internal structure. This contrast may produce a change in the preconceptions of the reader. Section 2 examines Meillassoux’s approach to Mallarmé’s poem, which is preoccupied with a “number” supposedly encrypted in the text. This is not convincingly related to the propositional structure of the poem. In Section 3, the text is interpreted using a semiotics-based methodology. The poem is generated by two matrices: one concerning the “Master” versus the storm, and the second concerning the power of Chance. The relation linking the matrices is clarified. This analysis is compared with that of Meillassoux throughout. Section 4 resumes the differences between Meillassoux’s concentration on the “number” and the “siren,” and my analysis which centres on the relation between the Master (symbolising traditional poets and their preferred metre) and the Constellation (symbolising the wide range of new future poetic metres and formats). Meillassoux’s approach turns out to be unconvincing. (shrink)

Autophagy, an essential cellular process for maintaining cellular homeostasis and eliminating harmful cytoplasmic objects, involves the de novo formation of double‐membraned autophagosomes that engulf and degrade cellular debris, protein aggregates, damaged organelles, and pathogens. Central to this process is the phagophore, which forms from donor membranes rich in lipids synthesized at various cellular sites, including the endoplasmic reticulum (ER), which has emerged as a primary source. The ER‐associated omegasomes, characterized by their distinctive omega‐shaped structure and accumulation of phosphatidylinositol 3‐phosphate (...) (PI3P), play a pivotal role in autophagosome formation. Omegasomes are thought to serve as platforms for phagophore assembly by recruiting essential proteins such as DFCP1/ZFYVE1 and facilitating lipid transfer to expand the phagophore. Despite the critical importance of phagophore biogenesis, many aspects remain poorly understood, particularly the complete range of proteins involved in omegasome dynamics, and the detailed mechanisms of lipid transfer and membrane contact site formation. (shrink)

Ḥadīths have been preserved and recorded in various ways since the Companions. These activities continued dur-ing the Tābiīn (the successors of the Companions) Period. So much so that these methods have formed the infra-structure of other methods that will emerge later. In this context, before the 70's (A.H.), works named al-Aṭrāf appeared. However, these first works consisted of the notes that they wrote some of the ḥadīths before coming to the science assemblies to help students remember in ḥadīth learning. (...) Ḥadīth scholars have adopted and applied this method in a very short time. Thus, this method also provided the opportunity for the formation of the first written ḥadīth documents. In addition, with the writing of ḥadīth works, it has turned into a system of al-Taṣnīf and al-Takhrīj in order to make maximum use of these books and to reach the source of a narration that is tried to be found. As a result, al-Aṭrāf literature, which can be evaluated as index, has emerged. As a matter of fact, the first examples of this literature, arranged alphabetically according to the names of the Companions or ḥadīth texts, started to be given since the 4th (A.H.) century. In this way, the way to quickly benefit from the accumulation of the ḥadīth area has been opened. This article focuses on the historical adventure of al-Aṭrāf and their contributions to the ḥadīth field, as well as literature knowledge of the works of al-Aṭrāf which are of great importance for both al-Kitābah, al-Taṣnīf and al-Takhrīj.Summary: In order to understand and practice the religion of Islām, great efforts have been made both in the past and later periods in order to convey the words, verbs, interpretations and qualifications of the Prophet to the next genera-tions as they are protected from all kinds of falsification and changes. This process, which started with memoriza-tion and partly writing at the beginning, has gained momentum with the use of other methods since the period of Tābiīn. In this context, the method of aṭrāf was started to be used to facilitate memorization, to be a reminder, and to transmit the ḥadīth through the hearing of the ḥadīth sheikh. The first examples of this method were seen by Muḥammad b. Sīrīn during his participation of his teacher Abīde/Ubayda Salmān in the scholarly assembly. At this stage, the relevant method was manifested as writing a passage from the beginning of the ḥadīth. Thus, the aforementioned method, which had great contributions in recording and memorizing ḥadīths in accordance with the original, has gained widespreadness and application among the ḥadīth scholars like Ubeydullaḥ b. Omar, Shu’bah b. al-Ḥajjāj, Sufyān as-Sawrī, Mālik b. Anas, Ismāīl b. Ayyāş and Vakī b. Jarrāḥ in a very short time. In this context, Yazīd b. Zuray’ stated that he went to his teacher without his aṭrāf work of ḥadīths which he transmitted from Shu’bah and listened to ḥadīth in this way. Therefore, this mentioned event is important in terms of putting forth that Shu’bah allowed the aṭrāf method in his assemblies. The method was used by Aḥmad b. Ḥanbal, who traveled to Madīnah to convey the reports recorded with the mentioned method of his teacher Abū Alḳama al-Farawī and at the same time listen to the related transfers from him, but who could not reach his goal. Therefore, the related narrations show that aṭrāf method was used effectively by ḥadīth scholars to remember the ḥadīths in the 1st and 2nd centuries, so sections from the narrations were written during the preparatory stage before coming to the scholarly assembly. Ultimately, the importance of these works, which manifest in different ways and offer great contributions to writing, is an undeniable reality for the history of ḥadīth.Aṭrāf, the plural form of taraf that literally means the side and edge of something, mean a section, phrase or first part that indicates the whole of the ḥadīth. This method, along with the formation of ḥadīth literature, has been started to be given as a name to the works organized alphabetically according to the name of the Companions or ḥadīth texts by mentioning some of the ḥadīths with the 4th century. In this sense, aṭrāf has started to become a unique literature in a sort of taṣnīf and takhrīj method in order to make use of the ḥadīth writing easier.Aṭrāf studies may aim to bring together the isnāḍs (chains of transmitters) in all books, or they can be limited to the chains in certain books. Aṭrāf books contain the ḥadīths in the Ṣaḥīḥān or Kutub al-Sittah and are written in alphabetical form based on the name of the companions or according to the texts of ḥadīth. The first of these, which has the attribute of the musnad in a sense, is arranged in alphabetical order according to the name of the Companion, and if there are many people who narrate from him, according to the names of the tābiīn and taba-i tābiīn (successors of the tābiīn). Accordingly, the narrations of each companion were determined and listed in al-phabetical order in aṭrāfs in musnad-type, and a passage was written from the ḥadīths and marked as books/chapters in the places of relevant narration. On the other hand, the second type of aṭrāf books were ar-ranged by giving a few words from a section that allows remembering the head or all of the ḥadīths without in-cluding chains, and then placing these texts in alphabetical order.The type of aṭrāf offers the opportunity to see different chains of narrations together and provides many facilities for the ḥadīth researchers. Therefore, ḥadīth researchers show great interest in this genre. Aṭrāfs provide many benefits for both ḥadīth chain and text. In this respect, it is possible to talk about many advantages of the ḥadīth to its transmister such as the determination of mutawātīr, garīb, azīz, mashhūr, mutābī or the testimony of ḥadīth; to provide facility to make a reputation research of a riwāyah (narration), to provide an opportunity to determine the location of the narrations in the primary sources; to detect the link or any blackout in the chain, to reach the nu-merical knowledge of ḥadīth narrated by a companion or other narrators, to obtain information about narrators whose identity is not explicitly stated, to know the first narrator, to provide the protection of the ḥadīths from taḥrīf or alteration, to give the opportunity to identify the subject they contain, to be able to obtain text integrity by getting various chains, the detection of the sabab al-wurūd (the context of ḥadīth).Due to the contributions we have mentioned above, many books on aṭrāf literature that started with Abu’l-Ḥasen Ali b. Omar ad-Dārakutnī have been published. Among them Aṭrāfu’s-ṣaḥīḥayn/el-Jem`u bayna’s-ṣaḥīḥayn by Abū Mas`ūd Ibrāhīm b. Muḥammad b. Ubayd ad-Dimashkī, Aṭrāfu’s-ṣaḥīḥayn by Abū Muḥammad Ḥalaf b. Muḥammad b. Ali al-Vasiṭī, Zaḫāiru’l-mavārīs fi’d-dalālati alā mavāzi`i’l-hadīs by Abdülganī b. İsmāīl en-Nāblūsī and Tuḥfatu’l-ashrāf bi ma`rifati’l-aṭrāf by Abu’l-Ḥajjāj Yūsuf b. Abdurrahman el-Mizzī can be mentioned. Some of the related works are arranged in musnad style while others are arranged according to the first word of ḥadīth texts. As a result, the method of aṭrāf has become a kind of indexer in order to facilitate reaching the source of the re-ports and make the highest level of use required by the classification and bookings of the ḥadīths in the 3rd centu-ry. These works, arranged alphabetically in the name of the Companions or according to the texts of the ḥadīth, have taken their place in the history of the ḥadīth with their many examples, both in the form of taṣnīf and the method of takhrīj by mentioning a part of the ḥadīth by the head. (shrink)

Atheism is skeptical towards gods, and atheology advances philosophical positions defending the reasonableness of that rejection. The history of philosophy encompasses many unorthodox and irreligious movements of thought, and these varieties of unbelief deserve more exegesis and analysis than presently available. Going back to philosophy’s origins, two primary types of atheology have dominated the advancement of atheism, yet they have not cooperated very well. Materialist philosophies assemble cosmologies that leave nothing for gods to do, while skeptical philosophies find conceptions (...) of god to be too unintelligible or unsupported by evidence to warrant credibility. The origins and genealogies of these two atheologies are sketched and compared over many centuries down to present-day atheism, which still displays signs of this internecine divide between confident naturalists and agnostic skeptics. (shrink)

Responsible risk management is central to banking ethics. With the 1999 publication of the Basel Committee's proposal, Basel II, for a New Capital Accord to replace the 1988 agreement, Basel I, an attempt has been made to address the problem of correlating banks' risk management with their capital requirements. The Basel II framework, finalised in June 2004, is designed to improve risk management by using models based on past performance to help set the amount of capital banks are required to (...) hold by regulators, with the purpose of improving the efficiency of capital allocation. The objectives of this study are to investigate how banks generally, but particularly those located in China, could improve their risk management systems and what the implications of these new regulations are for them. Three relevant propositions were formulated, namely, Basel II will improve risk management; Basel II will improve capital allocation efficiency; and compliance with advanced risk management systems is biased in favour of the large banks. Evidence was assembled with which to evaluate these three propositions by gathering relevant primary data by means of a representative survey of Chinese banking executives involved in risk management. The findings strongly support the first two of the above propositions and partly support the third proposition. (shrink)

Courses on bioethics and the law traditionally have focused their coverage on ethical issues arising from individual patients’ encounters with the medical care system, but the course also provides an excellent opportunity to expose students to ethical issues arising at the intersection of medical care and public health. The following materials were assembled for use near the end of a semester-long law school course in Bioethics & Law. I taught the course relying heavily on problems contained in Barry R. Furrow (...) et al., Bioethics: Health Care Law and Ethics, 7th ed., which was the primary text for the course. (shrink)

A Metaphysics for Scientific Realism: Knowing the Unobservable has two primary aims. The first is to extract the most promising refinements of the idea of scientific realism to emerge in recent decades and assemble them into a maximally defensible realist position, semirealism. The second is to demonstrate that, contra antirealist scepticism to the contrary, key concepts typically invoked by realists in expounding their views can be given a coherent and unified explication. These concepts include notions of causation, laws of (...) nature, scientific kinds, and approximate truth, and consequently, the demonstration undertaken includes a metaphysical study of ideas more commonly employed unreflectively in epistemological assessments of the sciences. In this paper, I answer searching critiques of this project by Steven French, Michel Ghins, and Stathis Psillos. (shrink)

To further comprehend how synthesis and assembly of myofibrillar components is regulated, several laboratories have undertaken genetic studies of muscle development in Drosophila melanogaster. This small fly lends itself well to classical and molecular genetic approaches, and possesses a set of muscle fibers, termed indirect flight muscles (IFM), which is particularly advantageous for such investigations. Structural and functional analyses of cloned Drosophila contractile protein genes have revealed that protein isoforms can be specified either by multigene families or by differentially splicing (...) primary transcripts of a single gene. Characterization of mutations which disrupt flight muscle development has so far revealed that profound abnormalities are caused by defective alleles of actin, tropomyosin, and myosin heavy‐chain genes. Muscle defects associated with particular alleles can be alleviated by integration of corresponding wild‐type gene copies into germ‐line chromosomes. Strategies for further applying genetic techniques to investigations of Drosophila muscle development are discussed. (shrink)

Any sort of cognition, perception, and action is necessarily shaped by (re)activation of “schemata.” Any interpretation is schema (re)activation. Schemata are epistemologically speaking “structural” activation patterns which are psychologically and neurologically speaking accommodated, adapted, “learned” by co- and re-activating neuronal assemblies. Six levels of interpretative schema activations (schema interpretations) are outlined from invariable primary “interpretations” through conventional, classificatory, and justificatory, as well as meta-interpretations. Constitutive schema interpretations are unavoidable. Many philosophical problems will have to be reformulated or reinterpreted (...) along these lines, e.g., a sort of moderated pragmatic (interpretational) realism in epistemology. (shrink)

Any kind of knowledge, cognition, perception, and action is necessarily shaped by activation of "schemata". Any interpretation is schema activation. Schemata are epistemologically speaking "structural" activation patterns which are psychologically and neurologically speaking accommodated, adapted, "learned" by activating neuronal assemblies. Six levels of interpretative schema activations are outlined from invariable primary "interpretations" through conventional, classificatory and justificatory as well as meta-interpretations. Constitutive schema interpretations are unavoidable. Many philosophical problems will have to be reformulated or reinterpreted along these lines.

The roles of abductive inference in dynamic heuristics allows scientific methodologies to test novel explanations for the world’s ways. Deliberate reasoning often follows abductive patterns, as well as patterns dominated by deduction and induction, but complex mixtures of these three modes of inference are crucial for scientific explanation. All possible mixed inferences are formulated and categorized using a novel typology and nomenclature. Twenty five possible combinations among abduction, induction, and deduction are assembled and analyzed in order of complexity. There are (...) five primary categories for sorting these inferential procedures: fallacies, non-scientific procedures, quasi-scientific procedures, scientific procedures, and scientific heuristics. (shrink)

The roles of abductive inference in dynamic heuristics allows scientific methodologies to test novel explanations for the world’s ways. Deliberate reasoning often follows abductive patterns, as well as patterns dominated by deduction and induction, but complex mixtures of these three modes of inference are crucial for scientific explanation. All possible mixed inferences are formulated and categorized using a novel typology and nomenclature. Twenty five possible combinations among abduction, induction, and deduction are assembled and analyzed in order of complexity. There are (...) five primary categories for sorting these inferential procedures: fallacies, non-scientific procedures, quasi-scientific procedures, scientific procedures, and scientific heuristics. (shrink)

continent. 1.2 (2011): 141-144. This January, while preparing a new course, Robert Seydel was struck and killed by an unexpected heart attack. He was a critically under-appreciated artist and one of the most beloved and admired professors at Hampshire College. At the time of his passing, Seydel was on the brink of a major artistic and career milestone. His Book of Ruth was being prepared for publication by Siglio Press. His publisher describes the book as: “an alchemical assemblage that composes (...) the life of his alter ego, Ruth Greisman— spinster, Sunday painter, and friend to Joseph Cornell and Marcel Duchamp. Through collages, drawings, and journal entries from Ruth’s imagined life, Seydel invokes her interior world in novelistic rhythms.” This convergence of his professional triumph with the tragedy of his death makes now a particularly appropriate time to think about Robert Seydel and his work. This feature contains a selection of excerpts from Book of Ruth (courtesy of Siglio Press) alongside a pair of texts remembering him and giving critical and biographical insights into his art and his person. These texts, from a former student and a colleague respectively, were originally prepared for Seydel's memorial at Hampshire College and have since been revised for publication in continent. For more information on Book of Ruth, please visit the book's page at the Siglio Press website. —Ben Segal draughty R. * Lauren van Haaften-Schick 2011 “The most apt way to order Smithson's library is with the conjunction 'and'; science and religion; modernism and mass culture; what is present and what is missing.” —Alexander Alberro, 248 Robert Seydel's classes on collage and collecting immersed his students in a curious world of cabinets, oddities, exhaustive archives and obscure histories, explored always with critical rigor and a sincere eye for wonder. His office was a compendium of the ancient, mythic, potential and unworldy, where seemingly unrelated references were endlessly pulled, piled and fused in an ecstatic dance of hyper-annotation. The small room and all its contents overflowed with notes tucked in every margin and corner. Books coated the walls like a switchboard, anxious and humming, waiting for infinite links to be activated. William Blake's books of Job and Urizen summoned Greek mythology and the animal as metaphor, leading to 19th century cryptozoology and the cave paintings at Lascaux, Gaston Bachelard's description of the bird in his garden and Robert Rauschenberg's Canyon . Tracking archetypes and following tangential threads, new revelations and ancient narratives were compiled and ordered to form a new text, a bibliography as assemblage, portrait and poem. Robert's library—one of his many collections—is a portrait, an “artifact, collage of time, a token and remnant” (Seydel, 2007) He is humming with it still. The imagination of this room—of Robert—breathes through the pages of Book of Ruth, as every decision and detail unfolds to a cosmos. Allegory, invention, personal and art histories are entangled and leveled, rendering lived, perceived and absorbed experiences indistinguishable. Anonymous scraps discovered on the street or studio floor, careful clippings and drawn figures are chosen and animated through serendipitous destruction and whimsical, delicate positioning. A precise vocabulary of characters and terms erupts and collapses as personas and passers-by wave and whisper, “Every figure reveals aspects of the total form, which is open and green” (Seydel, 2007). The initials R.S. repeat, a nod to Robert's true family tree and further complicating identification. Robt, Robert's sometimes alter-ego, appears in myriad forms as a trickster “half-wit,” mercurial and skittish, or soft and worn thin. Saul is a solemn tinkerer, parsing the world and sometimes blind. Ruth, the speaker of the book, records and translates all, her voice wavering between poetic verse and a cryptic half-speech as complex as it is sparse. The rhythm of frayed edges sets time - the weight of the world and the lightness of paper. Robert wrote of his process, “Material is essential; scuffings carry history, which wanders throughout” (Seydel, 2007). Collectors, assemblers, sway between careful movements of selection and placement as they pull from the found world, mediating calculated and unconscious association to form a lexicon of gestures, symbols and allusion, the “artifacts of a life... the refuse and rejecta of days” (Seydel, 2007). These assembled fragments shift and chatter, at home in their homelessness, actors performing in their own lives, populating an invented world of similar orphans. Such accumulated, severed parts carry the injury of their cutting and retain the evidence of their source, binding loss to creation in a symbiosis of trauma and repair. Mourning and remembrance are deeply embedded in the histories and acts of such practices. Grievance, acceptance, and the fragility of life are conveyed in the 18th century allegorical arrangements of fetal specimens by Frederik Ruysch. A certain melancholy reverence colors Joseph Cornell's intimately tactile assemblages rendering the universe tangible in miniature, or made in devotion to unrequited loves. Preserved in stasis, these ghosts and idols are kept in a purgatory where fact and fiction, past and present are irrelevant distinctions. Catalogued and contained, the subject of loss is transferred to an artifact. Every thread, scrap and letter may be glued, gathered and placed in a museum, a tomb, a box, a page, ripe and open for possession. Holding on to grief and reveling in disrepair, we opt to be haunted. Forever unbalanced and in flux, the sublime of collage is its resolve to irresolution. For Robert, “Art, as creation and as sign of primary Imagination, is not objects but a state, a kind of fluid” (Seydel, 2007) Reflecting on his work, life, and death, I am drawn to my library and the myriad titles acquired through his inspiration. There is Daniel Spoerri's An Anecdoted Topography of Chance , Susan Stewart's On Longing , various Borges, Barthes, Perec, and especially Life: A User's Manual , which concludes that the perfect puzzle will have no solution. I think of the drawers of miscellaneous swallowed objects at the Mutter Museum, Ray Johnson coding the every day in riddles, Wallace Berman twisting tongues, and Susan Hiller laying every detail to bear. Collectors and makers working in endless cycles of observation, ingestion and display. Every gesture informs and is defined by others, every space is shaped by that which surrounds and fills it, the knot has an inner logic, the gigantic is not so different from the miniature, there is a world in every detail, and “All art is collage” (Seydel, 2011) These thoughts have molded my life, my art, and all the minutia that keep the two so profoundly intertwined; There is no difference between life and what we do with our time. “I write my life. I make me up.” What a gift to share this secret way of knowing the world, and to leave this knowledge for us to do with what we please. “Art begins in admiration” (Seydel, 2011) Lauren van Haaften-Schick is a curator, writer and artist based in New York. Upcoming curatorial projects include "Cancelled" at the Center for Book Arts, and "The Spirit of the Signal" at Nicole Klagsbrun Gallery, New York. Recent activities include the workshops "Market, Alternative" and "Alternative Art Economies" at Trade School and Momenta Art, and the e-flux Time/Store, New York. She is the founding director of two arts spaces in Northampton, MA and Philadelphia, PA. She received a BA in Art History and Studio Art from Hampshire college in 2006. Sura Levine on Robert Seydel If early on in his time at Hampshire College I was officially his “mentor,” Robert Seydel quickly became one of my great teachers. Over the years we talked about everything, from art, music, collage, and poetry, to campus politics, this latter far too often. It was always a sublime pleasure, if all too rarely done, to enter his apartment to look at his work in progress, to peruse his bookshelves where, inevitably, there were always new treats to examine. And, while he was working on his Book of Ruth , I was given the opportunity over the course of many meals at the Korean and other restaurants, to talk with him about image and poem ordering. To see how he thought through each comma, each juxtaposition across the gutters of the Book, was to watch a brilliant curator at work. Each day, I walk past his wonderful collaged portrait of Ruth, purchased, after much haggling, as a birthday present, a couple of years ago. And each day, I think how lucky I am to have known Robert as he produced this magnum opus. One of my greatest pleasures in 24 years at the College was to teach “The Collector” with Robert. One of my greatest regrets is that the magic we created together in the classroom will not, and cannot, be duplicated. Its various incarnations, its utter intelligence and magic, were all so deeply Robert’s. His was a mind that put poetry, philosophy, history of science, and history together with art, and art together with music. His intellect and eye were unparalleled. He introduced us to so many artists. He shared his fascination with the cabinets of curiosity of Aldrovandi, of Seba, and Peter the Great’s collection of fetal anomalies, as well as the Museum of Jurassic Technology in Los Angeles. Robert knew them all and so many more. He was a walking encyclopedia, his home a great archive. Arcane knowledge, perhaps, but oh so important for another of Robert’s heroes, the mid-20th century Belgian artist Marcel Broodthaers, whose name he invariably mispronounced as “Broadthayers.” In speaking his name, Robert would always look in my direction in a panic, and then he go on and maul it. I absolutely loved his various mispronunciations of French names and terms! “The Collector” was always filled with talented young artists, art historians, philosophers and writers who all came to understand the wondrous obsessions of the figure of the collector. Students in this course created dazzling projects each term. He always moved while looking and speaking. He read deeply, and commented on everyone’s work with wonderful generosity. Robert always found something to praise even in the least developed of projects. Robert inspired and mentored all of his students into making work that far exceeded their expectations—and ours. For those of you who were lucky enough to have been touched by or to have had an evaluation written by Robert, savor it, keep it, reread it, and share it. He loved working with you all; it is somehow fitting that he died while prepping yet another new course. Robert, it’s almost impossible to speak of you in the past tense, even though you left us a month ago. No doubt, if you knew about our gatherings and celebrations of you, you would be embarrassed that we are making a fuss over you; you always placed the focus on others rather than on yourself. This trait is exactly why so many people miss you now. We’re here to love you publicly as we all did privately for the eleven years you were among us. Robert, my very dear friend, you were an extraordinary artist—you were my brother of choice. My heart broke when yours did. I miss you profoundly. —Sura Levine, February 26, 2011 Sura Levine is a professor of art history at Hampshire College. Her field of specialty is 19th century Belgian and French art, particularly realism and impressionism. Having worked in museums for a number of years both prior to coming to the College, and, as guest curator and co-author of exhibition catalogues, she became particularly interested in the history of museum and trends in collecting. It was because of their shared interests that she and Robert Seydel developed their course, The Collector, which they co-taught for many years. (shrink)

According to Tocqueville, the freedom of the press, which he treats as an extension of the freedom of speech, is a primary constituent element of liberty. Tocqueville treats the freedom of the press in relation to and as an extension of the right to assemble and govern one’s own affairs, both of which he argues are essential to preserving liberty in a free society. Although scholars acknowledge the importance of civil associations to liberty in Tocqueville’s political thought, they routinely (...) ignore the importance he places on the freedom of the press and speech. His reflections on the importance of the free press and speech may help to shed light on the dangers of recent attempts to censor the press and speech. (shrink)

The Islamic education curriculum in Indonesia tends to be partial and dichotomous. However, Muhammadiyah has reformed the holistic–integrative curriculum as a solution for the sustainability of education. This study aims to reveal a special curriculum reform in the holistic–integrative Muhammadiyah education system to solve the dichotomous problems and the inadequacy in the Islamic education curriculum in Indonesia. Furthermore, the study describes a specific curriculum model that includes all aspects of students’ personality and integrates science and technology with Islamic values. Data (...) were collected from previous studies and special curriculum documents of Al-Islam, Kemuhammadiyahan and Arabic Language (ISMUBA). Curriculum documents were obtained from elementary, junior and Muhammadiyah senior high school, published by Primary and Secondary Education Assembly of Muhammadiyah Central Board in 2017. Data analysis used a content model with a systematic and rational framework. The results showed that the special reform curriculum based on the holistic–integrative model develops students’ potentials, including spiritual, emotional, intellectual and transcendental intelligence, in an integrated manner. Contribution: The holistic–integrative curriculum is a future Islamic education model for the sustainability of private Islamic education system in Indonesia that can form a good, faithful, pious and a noble community. (shrink)

The 1998 Good Friday Agreement (GFA) brought an end to conflict in Northern Ireland (NI). However, the peace process has not brought about the reconciliation which many had hoped for. The purpose of this article is to consider the role of ‘peace education’ and ‘integrated education’ in fostering reconciliation in Northern Ireland. My research contains the views of primary school and secondary school principals and head teachers to ‘peace education’ and ‘integrated education’ in Northern Ireland. The research is positioned (...) in the tradition of previous research literature and contemporary concerns relating to integrated education and the Shared Education Bill that was passed by the Northern Ireland Assembly on the 8th March 2016. My research adds to the emerging knowledge in the area and offers an insight on the attitudes of educators in Northern Ireland to ‘peace education’ and ‘integrated education’. It also engages with ‘interventionist research’. This paper is written from the point of view that genuine and effective ‘peace education’ requires ‘integrated education’ where children from diverse backgrounds are educated together every day in the same classrooms. (shrink)

This article interrogates the interface between the older Pentecostal movement and politics in Zimbabwe. The country continues to face political violence and a breakdown in rule of law. The Zimbabwean populace is asking whether the Zimbabwean Pentecostal movement is ready and able to exercise its prophetic role in promoting real peace and democracy. Many Zimbabweans are asking this question, because the track record shows that whilst most mainline churches have been consistent in becoming the voice of the voiceless, some Zimbabwean (...) Pentecostal churches seem to have been sitting on the fence for too long by adopting a middle of the road stance, thereby avoiding a head-on confrontation with the corrupt Zimbabwe African National Union–Patriotic Front government. In this article, I argue that for many decades the Zimbabwean Pentecostal movement has taken what one might refer to ironically as a ‘smart approach to politics’–in which the image of the ZANU–PF government is sanitised by espousing what I call a ‘spiritualised political theology.’ I use this critique, whilst remaining cognisant of the fact that the primary motivation of the movement on which I focus in this article, was evangelism, not politics. Thus, for the purpose of this research, the Zimbabwe Assemblies of God Africa of Apostle Ezekiel Guti was sampled to investigate its prophetic voice in a polarised political environment. This article examines the history of Apostle Guti’s political subterfuge based on the reflections of his pastoral letters referred to as the ‘Ten-days prayer letters’ issued since 1975 up to the time of writing this article. It is important at this early stage to outline that these letters were not political statements or meant to address politics only but theological letters addressing different social ills including politics. Thus, reading this letter one shall see that Apostle’s political subterfuge demonstrated a continuous oscillation of a theological position on how the church should relate to politics. Furthermore, I undertake a brief examination of other few millennial Zimbabwean Pentecostal churches to see if this political subterfuge transcended elsewhere thereby propagating a spiritualised political theology.Contribution: What is key to note is the fact that the Zimbabwean Pentecostal movement remained insignificant with regard to democratization agenda even after the removal of President Mugabe. The above claim is evidenced by the Zimbabwean Pentecostal church founders’ continuous political subterfuge authenticated by a propagation of a spiritualized political theology. (shrink)